Digital Commons Network^™

Multi-Material Hybrid Additive And Subtractive Manufacturing Of Photonic Devices, Roger Brandon Tipton

USF Tampa Graduate Theses and Dissertations

Optoelectronics focuses on the application of electronic devices that utilize forms of electromagnetic radiation including visible light and other wavelengths including ultraviolet and infrared. Optoelectronics typically include devices that emit light and detect light. Devices created using this technology include light-emitting diodes, laser diodes, photoresistors, photodiodes, solar cells, phototransistors, and fiber optics. Fiber optic interconnects are interesting devices in that they are used in conjunction with optoelectronic devices to transmit information between individual optoelectronic components.

Optoelectronics are typically produced by traditional lithography methods including etching, writing, and printing on rigid silicon substrates for fabricating devices. Other techniques like glass or …

Expansion-Contraction: Spatial And Temporal Variability In Connectivity In A Stream-Wetland Flow Network, Savannah Fransbergen

USF Tampa Graduate Theses and Dissertations

The seasonal expansion and contraction in a stream-wetland flow network is often difficult to characterize due to a lack of accurate mapping products, but proper characterization is important for the management of these resources. A new approach to mapping hydrography, resulting in a Regional Hydrography Dataset (RHD), may offer additional insights not provided by the national standard, the National Hydrography Dataset (NHD). The RHD can be customized to provide seasonal or monthly hydrograph, whereas the NHD is static. We conducted field validation (241 sites) and geospatial analyses to assess the accuracy of these products in the northern Tampa Bay Area. …

Effects Of Nitrate On Arsenic Mobilization During Aquifer Storage And Recovery, Hania Hawasli

USF Tampa Graduate Theses and Dissertations

Aquifer storage and recovery technology is used to sustain water resources and to prevent saltwater intrusion. The injected water can come from various resources, including treated wastewater. In pilot ASR studies in the Tampa Bay region, researchers found high As concentrations in the recovered water from the oxidation of the arsenopyrite that is embedded in the aquifers. The presence of dissolved O2 in the injected water is a major factor in the arsenopyrite oxidation during ASR, however the effects of NO3- on the arsenopyrite has not been studied yet. This is an important knowledge gap because injected water may contain …

Plasma Treatment Of High-Density Polyethylene, Linear Low-Density Polyethylene, And Polyvinyl Chloride Geomembranes By Air And Oxygen, Merve Koca Uyar

USF Tampa Graduate Theses and Dissertations

High-density polyethylene (HDPE), linear low-density polyethylene (LLDPE), and polyvinyl chloride (PVC) geomembranes were treated with air and oxygen plasma. The purpose of air and oxygen plasma treatment of geomembrane surface is to increase the surface wettability of these materials, thereby increasing adhesive properties. Increasing adhesive properties enables a surface to be coated with a desired material with antibacterial, antioxidant, and UV resistant characteristics, without changing bulk material properties. To protect the geomembranes from oxidation degradation, UV degradation and biological degradation, it is important to increase the antibacterial, antioxidant, and UV resistant properties of geomembrane. Before and after the plasma treatments …

The Multifaceted Role Of Ccar-1 In The Alternative Splicing And Germline Regulation In Caenorhabditis Elegans, Doreen Ikhuva Lugano

USF Tampa Graduate Theses and Dissertations

The Cell Division Cycle and Apoptosis Regulator (CCAR) family members are an enigmatic family of proteins regulating metabolism, cancer, apoptosis, DNA damage, and stress. Mammals have CCAR family members, CCAR1 and CCAR2/DBC1, which evolved from the founding family member CCAR-1/LST-3 expressed in Caenorhabditis elegans. Several studies have shown the importance of understanding these proteins' function in standard and altered physiological processes. Our studies aim to understand the genome-wide alternative splicing and germline regulation of Caenorhabditis elegans CCAR-1 in normal and heat shock conditions. Recently, mammalian CCAR family member CCAR2/DBC1 regulates the alternative splicing by forming a complex with ZNF326. This …

Material And Topographically Optimized Thermal Dissipation For High-Performance Electronic Devices Utilizing Vapor Chambers, Derek Joseph Daniels

USF Tampa Graduate Theses and Dissertations

Advances in materials science and engineering in the field of thermal transport and dissipation enable the use of higher-performance electronic devices that are smaller and generate more heat. Phase change thermal transport systems such as heat pipes and vapor chambers enable passive dissipation from devices that generate excessive heat without the need for actively pumped cooling systems. Properly designed vapor chamber enabled systems easily exceed the thermal conductivity of manufactured diamond at a small fraction of the cost.[1][2][3] While heat pipe phase change systems are generally one-dimensional with a limited cross section, vapor chambers are generally two-dimensional with a small …

Experiences Of Saudi Arabian Mothers Of Young Children With Disabilities: An Exploratory Study, Samirah Bahkali

USF Tampa Graduate Theses and Dissertations

Saudi Arabia is one of the countries that seeks to provide and develop services for children with disabilities and their families. As times have progressed, regulations and laws have placed an emphasis on providing suitable and better services for children with disabilities and their families. However, a gap exists in the literature regarding the overall experiences of Saudi Arabian mothers of children with disabilities in the early childhood years from birth to age ten (Al Otaibi & Al Sartawi, 2009; Alazemi, 2010). This study explored the experiences of Saudi Arabian mothers of children with disabilities. A qualitative interview approach, utilizing …

Assessing Morphological Response And Vulnerability Of Barrier Islands To Extreme Storms In Northwest Florida, Jacob Adam

USF Tampa Graduate Theses and Dissertations

Barrier islands shield the mainland coast from the effects of extreme storms such as increased wave energy and storm surge. During these events, however, barrier morphology can be altered by erosive forces. Thus, compromising the protection offered and leading to increased impact on the mainland. The St. Joseph Peninsula, located in the Northwest of the Gulf of Mexico, is one such barrier at threat from storm-induced erosion. Presented here is an assessment of morphology change induced by two major storms to impact the peninsula, Hurricanes Dennis 2005 and Michael 2018. These changes characterize the erosive/depositional patterns that can be expected …

Computer Simulation For Continuous Centrifugation Of High-Density Cell Cultures, Hironori Tomizawa

USF Tampa Graduate Theses and Dissertations

Perfusion bioreactors are used for cell production for cell therapies. The system uses cell separation devices such as centrifuge to facilitate cell growth by separating cells and spent media and allows constant media replacement. However, current cell separation technologies can increase shear stress, are generally not continuous processes, and are not as efficient as desired. These limit the amount of media replaced per unit time. Therefore, there is a need for a new system or a method that operates continuously to minimize cell damage, yield high cell concentration, and exchange media effectively. A set of research questions was formulated: (1) …

Synthesis Of A Multimodal Ecological Model For Scalable, High-Resolution Arboviral Risk Prediction In Florida, Sean P. Beeman

USF Tampa Graduate Theses and Dissertations

West Nile virus (WNV) and Eastern Equine Encephalitis virus (EEEV) represent the two greatest endemic arboviral risks to the state of Florida. Currently, no approved human vaccine exists for the prevention of either virus. In the absence of a vaccine, effective disease surveillance is paramount for public health. In Florida, WNV and EEEV sentinel chicken surveillance is conducted by mosquito control programs operated at the county, municipality, or special taxing district level. This program was implemented in 1978 following human outbreaks of St. Louis Encephalitis virus (SLEV) that occurred between 1959 and 1977, with initial sentinel coops placed in proximity …

Barriers And Motivating Factors To Parent Involvement In The Well-Being Promotion Program, Alexis C. Elvy

USF Tampa Graduate Theses and Dissertations

The Well-Being Promotion Program (WBPP) is a school-based positive psychology intervention implemented in both primary and secondary schools to increase subjective well-being in children and adolescents. Through the inclusion of a parent information session and weekly parent contacts, parents of students enrolled in the program are encouraged to enhance their child’s generalization of positive activities and relationship building skills. However, previous implementation of the WBPP provides evidence for the existence of barriers to parental involvement in the intervention. Although the literature on parental involvement in school-based positive psychology interventions is sparse, research conducted with a variety of school-based and clinical …

The Development Of Bioactive Peptidomimetics Based On Γ-Aapeptides, Minghui Wang

USF Tampa Graduate Theses and Dissertations

Peptidomimetics are small protein like chains which can mimic primary, secondary or eventertiary structures of peptides. They have been attracting more and more attention because of their special advantages, such as high tolerance to proteolytic degradation and thousands of chemical diversities. γ-AApeptides were developed by our group as a kind of peptidomimetics that represent γ-substituted-N-acylated-N-aminoethyl amino acids. Many biological functions of γ-AApeptides have already been discovered. To expand the potential application of γ-AApeptides, I designed and synthesized three series of antimicrobial derivatives with broad-spectrum of antibacterial activity. A one-bead-two-compound thioether bridged macrocyclic γ-AApeptides library was built and screened against NRF2 …

Mitigation Strategies For Central Nervous System Oxygen Toxicity In Rodents: Ketone Metabolic Therapy And Mitochondrial Antioxidant Therapy, Christopher Manuel Hinojo

USF Tampa Graduate Theses and Dissertations

Hyperbaric oxygen (HBO2) is a frequently encountered condition in undersea medicine and hyperbaric oxygen therapy (HBOT). The risk of CNS oxygen toxicity (CNS-OT) seizures limits its use in hyperbaric medicine and limits bottom time for diving operations. In this study, we sought to understand the role of reactive oxygen species (ROS) in two mitigation strategies for CNS-OT; ketone metabolic therapy (KMT), which is known to delay onset of CNS-OT seizures, and mitochondria targeted antioxidant therapy (MitoTAT), which has never been tested under HBO2 conditions. We specifically focused on superoxide anions, one of the early reduction products of molecular oxygen, and …

Cellular And Molecular Alterations Associated With Ovarian And Renal Cancer Pathophysiology, Ravneet Kaur Chhabra

USF Tampa Graduate Theses and Dissertations

Elucidating molecular alterations underlying tumor development and chemoresistance are critical to expand our understanding of the disease pathophysiology. This dissertation is focused on analyzing the cellular and molecular alterations associated with LPA-induced chemoresistance in clear cell renal cell carcinoma (ccRCC) cells and chronic iron-induced deregulation of miRNA expression in fallopian tube secretory epithelial cells (FTSECs).

Kidney cancer is one of the ten most common cancers worldwide with <15% survival rate at advanced stage (American Cancer Society). ccRCC is the most common type of kidney cancer and is described as a metabolic disease characterized by deregulated lipid metabolism leading to increased intracellular lipid droplets [9, 10]. The current molecular-targeted treatment strategies involve VEGF/VEGFR and mTOR inhibition [9, 12]. However, there are limitations to these approaches leading to the reduced efficacy and/or increased resistance in ccRCC cells [13, 14]. Therefore, it is important to decipher the factors involved in compromising the chemosensitivity in these cells.

Lysophosphatidic acid (LPA), a bioactive phospholipid, was previously reported to increase resistance against Sunitinib (VEGFR/PDGFR inhibitor) in ccRCC cells and to increase migration and invasion in various tumors [15-17]. In Chapter 3 of …

Social Constructivism In Chemistry Peer Leaders And Organic Chemistry Students, Aaron M. Clark

USF Tampa Graduate Theses and Dissertations

Social constructivist learning is a goal in many STEM programs. The goal of this dissertation is to shed light on what that pedagogy looks like in the context of organic chemistry courses and by peer leaders whose job is to implement this pedagogy with general chemistry and organic chemistry students. Learning is complex; the social constructivist ideas presented in this dissertation, however, are a straightforward means for promoting learning. Qualitative and quantitative methods used to explore social constructivist learning are outlined.

Three investigations were conducted: First, approaches to learning by students completing the first semester of a yearlong organic chemistry …

Synthesis Of Small Molecules For The Treatment Of Infectious Diseases, Elena Bray

USF Tampa Graduate Theses and Dissertations

Drug discovery’s impact on modern healthcare cannot be measured. In the past year, the world has watched scientists all around the globe work together to help protect the public from the novel coronavirus pandemic. Although sometimes slow and costly, drug discovery is important for advancing modern society. Drug discovery is at the core of treating diseases and in particular, infectious diseases. In the first chapter an overview of drug discovery will be discussed in a brief manner.

The second chapter will introduce infectious diseases. In modern society, the development of small molecule treatments for treating bacteria, viruses, and fungi has …

Water Regulation For Enhancing Soil Quality Using Cactus Mucilage: A Theoretical And Experimental Analysis, Khuloud Alrashdi

USF Tampa Graduate Theses and Dissertations

As water is one of the primary sources of life, it is essential in an endless number of systems and processes to be utilized efficiently in nature and in practical applications. One of these applications includes farming, which depletes a lot of water as the water irrigation systems cover large soil areas. While water is a critical factor in growing crops, a question here stands, can the irrigation process be transformed? This is the overarching goal of my work since it is centered on studying if cactus mucilage, a natural substance, is capable of improving water absorption processes on crops …

Adaptive Mobile Eeg Noise Cancellation Using 2d Convolutional Autoencoders For Bci Authentication, Tyree Lewis

USF Tampa Graduate Theses and Dissertations

Electroencephalography (EEG) signals can be used for many purposes and has the potential to be adapted to various systems. When EEG is recorded from users, these studies are performed primarily in an indoor environment, while the user is stationary. This is due to the levels of noise that are experienced when recording EEG data, to minimize errors in the data. This thesis aims to adapt tasks that are performed indoors to an external environment by removing both noise and artefacts in EEG, using a 2D Convolutional Autoencoder (CAE). The data is recorded from subjects is passed into the 2D CAE …

Computational Fluid Dynamics (Cfd) Analysis Of The Hydraulic Performance And Bio-Kinetics In A Full-Scale Oxidation Ditch, Kiesha C. Pierre

USF Tampa Graduate Theses and Dissertations

An oxidation ditch is a biological wastewater treatment unit process where microorganisms are utilized to transform organic matter, and nitrogen from wastewater to meet the desirable effluent concentrations. Mechanical aerators are part of these biological reactors facilitating oxygen transfer for the aerobic microorganisms, while agitating and circulating the phase constituents within the ditch. Modeling the performance of an oxidation ditch involves combining hydrodynamics, oxygen mass transfer, and bio-kinetics and is one of the grand challenges that is of paramount importance in optimization of design and operations of these facilities in an energy efficient way while meeting the targeted effluent concentrations. …

Screening Next-Generation Fluorine-19 Probe And Preparation Of Yeast-Derived G Proteins For Gpcr Conformation And Dynamics Study, Wenjie Zhao

USF Tampa Graduate Theses and Dissertations

GPCR regulates numerous diverse physiological processes relevant to diabetes, obesity, Alzheimer's diseases, and several central nervous system disorders and targets proteins in signaling pathways. It has created nearly 200 billion profits from its derivative drugs in 2018. There are near 400 structures of over 70 GPCRs have been resolved by X-ray crystallography, cryo-electron microscopy, and NMR spectroscopy. One of the current challenges that remain in the conformational transition and dynamics study using NMR spectroscopy is to obtain sufficient quantities of the G proteins and GPCRs. Pichia pastoris has shown its tremendous promise in expressing the GPCRs in a high yield, …

Mutational Analysis Of Latency Associated Peptide For Therapeutic Application, Johnny Will Stephens

USF Tampa Graduate Theses and Dissertations

TGF-β is an important protein for regulation of the immune system, and has been linked to promotion of tumor progression and cancer growth. Inhibiting TGF-β has been shown to be an effective therapeutic technique for fighting multiple cancer types. Engineering TGF-β’s natural inhibitor, Latency Associated Peptide (LAP), to improve its biophysical properties has potential to increase therapeutic efficacy.

Rosetta and FoldX can be used in concert to engineer stabilizing mutations of proteins. In accordance with this, PyRosetta and FoldX were used to predict stabilizing mutations of LAP. The most stabilizing mutations from each program were combined with mutually predicted mutations. …

Development And Validation Of A Scale To Measure Songwriting Self-Efficacy (Sses) With Secondary Music Students, Patrick K. Cooper

USF Tampa Graduate Theses and Dissertations

Social cognitive theory was developed to explain how individuals learn, in part, by witnessing the behavior of others. Self-efficacy is a construct within social cognitive theory which indicates the beliefs that an individual can be successful at a task under specific situational demands. The sources of self-efficacy include self-evaluating past experiences to predict future success, comparing our abilities to those around us, the verbal and social feedback we get from others, and the physiological feelings we experience when engaged in or thinking about the task. Measures of self-efficacy have been shown to be accurate predictors of successful learning outcomes, achievement, …

Preparation And Characterization Of Single Layer Conducting Polymer Electrochromic And Touchchromic Devices, Sharan Kumar Indrakar

USF Tampa Graduate Theses and Dissertations

Electrochromic devices (ECDs) have triggered great interest because of their potential applicability in energy-efficient buildings and low power display systems, including reflective type smart windows/mirrors and wearable-flexible devices. In the past decades, electrochromic technologies with different device structures and materials have been proposed. The idea of employing a simple device structure with a durable, cost effective electrolyte is crucial to designing and manufacturing high-performance ECDs. With this idea in mind, this thesis describes the various efforts to develop a simple ECD comprising of a composite single active layer gel electrolyte, sandwiched between two transparent conducting electrodes, lasting over 10,000 cycles …

Multidimensional Well-Being Across Time Scales In Caregivers And Non-Caregivers, Victoria R. Marino

USF Tampa Graduate Theses and Dissertations

Contemporary research on informal caregiving recognizes that, though stressful, providing care for a disabled family member or friend can bring psychological benefits, such as increased meaning or purpose in life, growing closer to the care recipient, and learning new skills. Scales of eudaimonic well-being (EWB – e.g., meaning in life, personal growth, and positive relations with others) developed in positive psychology literature offer an innovative solution to incorporating caregiving benefits into between-groups comparisons of caregiver and non-caregiver well-being, which have typically focused on cross-sectional assessment of hedonic well-being (HWB – i.e., negative/positive affect and life satisfaction). Moreover, using daily using …

Design, Deployment, And Validation Of Computer Vision Techniques For Societal Scale Applications, Arup Kanti Dey

USF Tampa Graduate Theses and Dissertations

Artificial Intelligence techniques have ensued a significant impact on our daily lives. Numerous applications in so many diverse fields have been made possible by AI algorithms today, and there are many more yet to come. In this dissertation, we design, deploy and validate computer vision algorithms for innovative and high-impact societal scale applications.We specifically focus on two applications in this dissertation: Detection of distracted driving and Detection of breeding habitats of mosquito vectors.

Distracted driving on roads is a major problem around the world. Distracted driving is the case where a driver diverts his/her focus from the road and engages …

Secure Vlsi Hardware Design Against Intellectual Property (Ip) Theft And Cryptographic Vulnerabilities, Matthew Dean Lewandowski

USF Tampa Graduate Theses and Dissertations

Over the last two decades or so, VLSI hardware is increasingly subject to sophisticated attacks on both the supply chain and design fronts. There is no explicit trust that the manufacturers/providers are not producing counterfeit designs or that cryptographic algorithms we know to be secure in software are also secure in hardware. The novelty and key contributions of this work are as follows: 1) a continually refined method for Intellectual Property (IP) Protection that provides an approach for verification of IP ownership, 2) demonstrate how to break the PRESENT-80 cryptographic algorithm with significantly limited resources, and 3) provide a multitude …

Advanced Organic Polymers For The Nanoscale Fabrication Of Fiber-Based Electronics Using The Electrospinning Technique, William Serrano Garcia

USF Tampa Graduate Theses and Dissertations

Electrospinning has become one of the most interesting techniques for fabricating nanofibers for multiple applications. The high surface-to-volume ratio nanofibers offer make the perfect structure for filters, sensors, and fiber-based electronics that could lead to a wide range of flexible electronics applications. This technique makes organic semiconducting polymers a promising alternative for single fiber electronics structures. Indeed, a wide variety of structures can be fabricated using electrostatic techniques for polymer manipulation from droplets, fibers, and coaxial structures. Although techniques such as electrospinning led the use of electrostatic forces to generate fibers of a precursor solution, electrospinning requires large enough polymer …

"25 Years Later And I'M Still Here...Still Positive": Older Black Males' Lived Experiences Of Aging With Hiv In Hillsborough County, Fl, Bernice Kathleen Lopez-Mccoy

USF Tampa Graduate Theses and Dissertations

Today, adults aged fifty and older are the fastest growing segment of those living with HIV/AIDS. Yet, little remains known about the socio-cultural consequences of aging with HIV, and whether social and health care infrastructure is currently adequate to meet the unique needs of this population. Particularly understudied are older minority men aging with HIV. Drawing from an anthropological life course perspective and tenets of Becker’s (1997) framework on life disruption and reorganization, this dissertation research investigated older, Black males’ experiences of disruption and reorganization from aging with HIV in the present landscape of HIV care.This research comprised of the …

Measuring Parental Involvement As Parental Actions In Children’S Private Music Lessons In China, Cancan Cui

USF Tampa Graduate Theses and Dissertations

Anonymity has long been discussed as a source of disinhibition. The myth of the Ring of Gyges illustrates how a person may act immorally solely because they know they will not be caught (Plato, 375/2017). Incorporating perspectives of rational choice and deterrence, anonymity serves as a form of risk reduction within hedonistic calculus (Beccaria, 1764/1963; Bentham, 1781/2000). Analogous to the myth of the Ring of Gyges (Plato, 375/2017), techniques of anonymity “hide” users from others while online. These techniques serve as a form of risk reduction, reducing the certainty of punishment (Becarria 1764/1963). Additionally, there are many ways by which …

The Adaptive, Social, Communication, And Cognitive Skills Of Monolingual And Bilingual Toddlers With Autism, Marcela A. Galicia

USF Tampa Graduate Theses and Dissertations

The rates of Autism Spectrum Disorder (ASD; Center for Disease Control [CDC], 2019) and bilingual individuals are rapidly increasing in the United States (Zeigler & Camarota, 2019). Yet, research on the global development of bilingual children with ASD is limited. Despite the lack of research in this vein, educators and clinicians are tasked with the assessment and intervention planning for culturally and linguistically diverse (CLD) children with ASD (Dilly & Hall, 2019). There are mixed findings regarding the effect of bilingual exposure on the development of adaptive, social, communication, and cognitive skills of children with ASD (e.g., Hambly & Fombonne, …