Digital Commons Network^™

Statistical Modeling And Prediction Of Hiv/Aids Prognosis: Bayesian Analyses Of Nonlinear Dynamic Mixtures, Xiaosun Lu

USF Tampa Graduate Theses and Dissertations

Statistical analyses and modeling have contributed greatly to our understanding of the pathogenesis of HIV-1 infection; they also provide guidance for the treatment of AIDS patients and evaluation of antiretroviral (ARV) therapies. Various statistical methods, nonlinear mixed-effects models in particular, have been applied to model the CD4 and viral load trajectories. A common assumption in these methods is all patients come from a homogeneous population following one mean trajectories. This assumption unfortunately obscures important characteristic difference between subgroups of patients whose response to treatment and whose disease trajectories are biologically different. It also may lack the robustness against population heterogeneity …

Chiral Phosphoric Acids And Alkaline Earth Metal Phosphates Chemistry, Tao Liang

USF Tampa Graduate Theses and Dissertations

Asymmetric synthesis and catalysis is one of the leading research areas in chemistry society, for its versatility and efficiency in obtaining chiral molecules that found the vast majority in natural active compounds and synthetic drugs. Developing asymmetric catalytic methodology is at the frontier in both industrial and academic research laboratories. Enantioselective organocatalysis has emerged as a powerful synthetic tool that is complementary to metal-catalyzed transformations. The development of chiral phosphoric acid and metal phosphate as catalysts has been a breakthrough in recent years. Chiral phosphoric acids have been shown to be powerful catalysts in many organic transformations. Moreover, chiral metal …

Bayesian Models Of Sequential Dependencies In Binary And Multi-Interval Response Tasks, Jeffrey Scott Annis

USF Tampa Graduate Theses and Dissertations

A sequential dependency occurs when the response on the current trial is correlated with responses made on prior trials. Sequential dependencies have been observed in a variety of both perception and memory tasks. Thus, sequential dependencies provide a platform for relating these two cognitive processes. However, there are many issues associated with measuring sequential dependencies and therefore it is necessary to develop measurement models that directly address them. Here, several measurement models of sequential dependencies for both binary and multi-interval response tasks are described. The efficacy of the models is verified by applying them to simulated data sets with known …

Assessing The Environmental Justice Implications Of Flood Hazards In Miami, Florida, Marilyn Christina Montgomery

USF Tampa Graduate Theses and Dissertations

While environmental justice (EJ) research in the U.S. has traditionally focused on inequities in the distribution of technological hazards, the disproportionate impacts of Hurricane Katrina on racial minorities and socioeconomically disadvantaged households have prompted researchers to investigate the EJ implications of natural hazards such as flooding. Recent EJ research has also emphasized the need to examine social inequities in access to environmental amenities. Unlike technological hazards such as air pollution and toxic waste sites, areas exposed to natural hazards such as hurricanes and floods have indivisible amenities associated with them. Coastal property owners are exposed to flood hazards, but also …

Interpolating Beach Profile Data Using Linear And Non-Linear Functions, Lance Calloway Croft

USF Tampa Graduate Theses and Dissertations

ABSTRACT

Beach and nearshore surveys are conducted in a variety of ways, the most commonly used being the level-and-transit method; because it is inexpensive, time conducive and highly accurate. Specifically, beach surveys are conducted to better understand cross-shore, long-shore sediment transport processes, as well as to quantify volume changes, which are used to evaluate beach performance. In this study, a section of the beach on Sand Key, FL was surveyed using rod-and-transit. In addition to the commonly used linear data analysis, a non-linear analysis was conducted using NURBS (Non-Uniform Rational B-Splines).

Survey data was collected within a short time window …

A Case Study Of The Roles And Perceptions Of Writing Coaches, Amy June Schechter

USF Tampa Graduate Theses and Dissertations

The purpose of this intrinsic case study was to explore the roles, responsibilities, and perceptions of writing coaches, a form of embedded professional development, which had the opportunity to assist teachers in deepening their pedagogical knowledge of writing instruction. Furthermore, this inquiry sought to describe middle school teachers' (N = 235) perceptions of how writing coaches may have impacted their beliefs and pedagogy with regard to writing instruction. At the time I conducted this case study, no extant literature existed to describe the roles, responsibilities, or perceptions of writing coaches, and this inquiry sought to fill that void.

In an …

Timing Of Svalbard/Barents Sea Ice Sheet Decay During The Last Glacial Termination, Tasha Snow

USF Tampa Graduate Theses and Dissertations

The Arctic and North Atlantic underwent significant climactic changes since the Last Glacial Maximum (25,000 years before present (1950 AD); ka BP), but offsets in the timing of events between the two regions are poorly constrained due to age model uncertainties that arise from changing radiocarbon reservoir ages. Here, we use a relatively high-resolution, multi-proxy stable isotope and sedimentologic dataset from Eastern Fram Strait (ODP Leg 162 Site 986) marine sediments to constrain the timing of Svalbard/Barents Sea Ice Sheet decay and infer deglacial reservoir ages over the last 30 ka. We use magnetic susceptibility, inorganic and organic carbon, foraminiferal …

Organic Fluids And Passive Cooling In A Supercritical Rankine Cycle For Power Generation From Low Grade Heat Sources, Rachana Vidhi

USF Tampa Graduate Theses and Dissertations

Low grade heat sources have a large amount of thermal energy content. Due to low temperature, the conventional power generation technologies result in lower efficiency and hence cannot be used. In order to efficiently generate power, alternate methods need to be used. In this study, a supercritical organic Rankine cycle was used for heat source temperatures varying from 125°C to 200°C. Organic refrigerants with zero ozone depletion potential and their mixtures were selected as working fluid for this study while the cooling water temperature was changed from 10-25°C. Operating pressure of the cycle has been optimized for each fluid at …

Forecasting Corrosion Of Steel In Concrete Introducing Chloride Threshold Dependence On Steel Potential, Andrea Nathalie Sanchez

USF Tampa Graduate Theses and Dissertations

Corrosion initiates in reinforced concrete structures exposed to marine environments when the chloride ion concentration at the surface of an embedded steel reinforcing bar exceeds the chloride corrosion threshold (CT) value. The value of CT is generally assumed to have a conservative fixed value ranging from 0.2% to - 0.5 % of chloride ions by weight of cement. However, extensive experimental investigations confirmed that CT is not a fixed value and that the value of CT depends on many variables. Among those, the potential of passive steel embedded in concrete is a key influential factor on the value of CT …

Recursive Methods In Number Theory, Combinatorial Graph Theory, And Probability, Jonathan Burns

USF Tampa Graduate Theses and Dissertations

Recursion is a fundamental tool of mathematics used to define, construct, and analyze mathematical objects. This work employs induction, sieving, inversion, and other recursive methods to solve a variety of problems in the areas of algebraic number theory, topological and combinatorial graph theory, and analytic probability and statistics. A common theme of recursively defined functions, weighted sums, and cross-referencing sequences arises in all three contexts, and supplemented by sieving methods, generating functions, asymptotics, and heuristic algorithms.

In the area of number theory, this work generalizes the sieve of Eratosthenes to a sequence of polynomial values called polynomial-value sieving. In the …

31p Dynamic Nuclear Polarization Applied To Dimethyl Methyl Phphonate For Functional Imaging And Spectroscopic Studies, Roha Afzal

USF Tampa Graduate Theses and Dissertations

In the recent years, Dynamic Nuclear Polarization (DNP) has emerged as a very promising technique for enhancing the sensitivity of the magnetic resonance spectroscopy and imaging (MRSI). A number of nuclei, namely 13C, 15N, 29Si, 89Y, and 129Xe, have been successfully polarized and a few of them have been employed in the in-vivo studies for functional imaging and metabolism. Hyperpolarized 13C-labeled compounds have wide applications in the metabolic and perfusion studies and can be used for early stage disease diagnosis, response to treatment, prognosis etc. DNP has been demonstrated in the 31P nucleus in nucleotides triphosphates as an application for …

Determining What Factors Affect Peoples' Perceptions Of The Use Of Reclaimed Water As A Source For Potable Water: A Study Within Hillsborough County, Florida, Susana Rebecca Alvarado Tricoche

USF Tampa Graduate Theses and Dissertations

In response to water supply depletion challenges, countries such as Australia, the United States, and Namibia have implemented technologies that treat wastewater up to the standards permissible to use for irrigation, toilet flushing, and even drinking water. However, many of these countries have been unable to successfully implement some of their ambitious reclaimed water reuse projects due to negative public perceptions of recycling wastewater. The focus of this study was to understand which factors in risk perception theory are the most influential in shaping community perceptions of reclaimed water reuse as a future source of drinking water within Hillsborough County. …

Analysis And Application Of Passive Gait Rehabilitation Methods, Ismet Handzic

USF Tampa Graduate Theses and Dissertations

Human gait is elegant and efficient in propelling the body forward. While a healthy human gait is symmetric, any deviation from symmetry can cause inefficiencies to the entire body. Such asymmetries may present themselves in hemiplegic patients, prosthetic users, lower limb injuries, limb height and weight discrepancies, or abnormal overground foot rolling. In this dissertation, practical passive methods to alleviate such asymmetric walking dynamics are presented. The novel concepts presented in this manuscript can all be related and applied to passive gait rehabilitation, that is, the rehabilitation of a person's gait through methods that do not require external power. One …

An Evaluation Of Florida Gulf Coast University's Residence Life Staff Member's Hurricane Preparedness, Erin Floto

USF Tampa Graduate Theses and Dissertations

Florida Gulf Coast University (FGCU) is located along the coast of the Gulf of Mexico in southern Florida, in an area vulnerable to hurricane strikes. At FGCU, The Office of Housing and Residence Life (OHRL) is responsible for three locations on- and off-campus where students reside in apartment or suite-style housing. Due to the large number of students with varying backgrounds, the OHRL staff members have become essential personnel during severe weather events that may cause safety concerns for the residents living in OHRL housing locations. This study's purpose is to assess the Residence Life staff on their level of …

Evaluation And Modeling Of Internal Water Storage Zone Performance In Denitrifying Bioretention Systems, Thomas Joseph Lynn

USF Tampa Graduate Theses and Dissertations

Nitrate (NO3) loadings from stormwater runoff promote eutrophication in surface waters. Low Impact Development (LID) is a type of best management practice aimed at restoring the hydrologic function of watersheds and removing contaminants before they are discharged into ground and surface waters. Also known as rain gardens, a bioretention system is a LID technology that is capable of increasing infliltration, reducing runoff rates and removing pollutants. They can be planted with visually appealing vegetation, which plays a role in nutrient uptake. A modified bioretention system incorporates a submerged internal water storage zone (IWSZ) that includes an electron donor to support …

Synthesis Of [1,2,4]-Triazines As Kinase Inhibitors And Of Novel Fluorine Capture Reagents For Pet Probes, Fenger Zhou

USF Tampa Graduate Theses and Dissertations

ABSTRACT

Anaplastic lymphoma kinase (ALK) is a tyrosine kinase receptor, which plays a pivotal part in the development of the central nervous system. Aberrant expression of full-length ALK occurs in neuroblastoma and chromosomal translocation or inversion of the ALK gene can generate novel fusion-ALK proteins that possess constitutive kinase activity and contribute to oncogenic processes. One of the well-studied fusion proteins is nucleophosmin (NPM-ALK), which draws a lot of attention for medicinal chemists to design small molecules as kinase inhibitors for this target. In this dissertation, [1, 2, 4]-Dihydrotriazine dimers as competitors of the lead compound NVP-TAE684 targeting NPM-ALK have …

Deriving Statewide Freight Truck Flows From Global Positioning System (Gps) Data, Akbar Bakhshi Zanjani

USF Tampa Graduate Theses and Dissertations

An accelerated growth in the volume of freight shipped on Florida's highways has led to a significant increase in truck traffic, influencing traffic operations, safety, and the state of repair of highway infrastructure. Traffic congestion in turn has impeded the speed and reliability of freight movement on the highway system. Appropriate planning and decision making processes are necessary to address these issues. However, a main challenge in establishing such processes is the lack of adequate data on statewide freight movements. As traditional data sources on freight movement are either inadequate or no longer available, new sources of data must be …

Use Of System Dynamics Modeling To Explicate The Theory-Of-Change Of A Social Marketing Innovation, Brian J. Biroscak

USF Tampa Graduate Theses and Dissertations

Community coalitions are an important part of the public health milieu and thus subject to many of the same external pressures as public health organizations--including changes in required strategic orientation. Many funding agencies have shifted their funding agenda from program development to policy change. Thus, the Florida Prevention Research Center created the Community-Based Prevention Marketing for Policy Development framework to teach community coalitions how to apply social marketing to policy change. The dissertation research reported here was designed to explicate the framework's theory-of-change. The research question was: "What are the linkages and connections between CBPM inputs, activities, immediate outcomes, intermediate …

Novel Models And Efficient Algorithms For Network-Based Optimization In Biomedical Applications, Seyed Javad Sajjadi

USF Tampa Graduate Theses and Dissertations

We introduce and study a novel graph optimization problem to search for multiple cliques with the maximum overall weight, to which we denote as the Maximum Weighted Multiple Clique Problem (MWMCP). This problem arises in research involving network-based data mining, specifically, in bioinformatics where complex diseases, such as various types of cancer and diabetes, are conjectured to be triggered and influenced by a combination of genetic and environmental factors. To integrate potential effects from interplays among underlying candidate factors, we propose a new network-based framework to identify effective biomarkers by searching for "groups" of synergistic risk factors with high predictive …

A Multi-Proxy Approach To Understanding Abrupt Climate Change And Laurentide Ice Sheet Melting History Based On Gulf Of Mexico Sediments, Clare Carlisle Williams

USF Tampa Graduate Theses and Dissertations

During the last deglaciation (ca. 24-10 ka thousand years ago (ka)), the North American Laurentide Ice Sheet (LIS) was a major source of meltwater to the Arctic Ocean, North Atlantic Ocean, and the Gulf of Mexico (GOM), and it is hypothesized that meltwater routing played an important role in regulating Late Quaternary millennial-scale climate variability, via its influence on Atlantic Meridional Overturning Circulation (AMOC). For example, the meltwater routing hypothesis predicts that a rerouting of meltwater from the GOM to the North Atlantic and/or Arctic Oceans resulted in a decrease of North Atlantic Deep Water (NADW) formation and subsequent cooling …

Paradise Always Already Lost: Myth, Memory, And Matter In English Literature, Elizabeth Stuart Angello

USF Tampa Graduate Theses and Dissertations

This dissertation follows a collection of agentive objects around and through the networks of humans and nonhumans in four disparate works of English literature: the Anglo-Saxon poem The Dream of the Rood, William Shakespeare's narrative poem The Rape of Lucrece, Thomas Hardy's novel The Woodlanders, and Philip Pullman's trilogy His Dark Materials. Applying the emergent discourses of object-oriented analyses, I posit the need for a critique that considers literary objects not as textual versions of real-world objects but as constructs of human imagination. What happens when we treat nonhuman or inanimate objects in literature as full …

Study Of Process Control Strategies For Biological Nutrient Removal In An Oxidation Ditch, Leslie Ann Knapp

USF Tampa Graduate Theses and Dissertations

Advanced wastewater treatment plants must meet permit requirements for organics, solids, nutrients and indicator bacteria, while striving to do so in a cost effective manner. This requires meeting day-to-day fluctuations in climate, influent flows and pollutant loads as well as equipment availability with appropriate and effective process control measures. A study was carried out to assess performance and process control strategies at the Falkenburg Road Advanced Wastewater Treatment Plant in Hillsborough County, Florida.

Three main areas for control of the wastewater treatment process are aeration, return and waste sludge flows, and addition of chemicals. The Falkenburg AWWTP uses oxidation ditches …

Stochastic Modeling And Analysis Of Energy Commodity Spot Price Processes, Olusegun Michael Otunuga

USF Tampa Graduate Theses and Dissertations

Supply and demand in the World oil market are balanced through responses to price movement with considerable complexity in the evolution of underlying supply-demand

expectation process. In order to be able to understand the price balancing process, it is important to know the economic forces and the behavior of energy commodity spot price processes. The relationship between the different energy sources and its utility together with uncertainty also play a role in many important energy issues.

The qualitative and quantitative behavior of energy commodities in which the trend in price of one commodity coincides with the trend in price of …

A Multi-Period Mixed Integer Linear Programming Model For Desalination And Electricity Co-Generation In Kuwait, Nael Abdulhameed Alqattan

USF Tampa Graduate Theses and Dissertations

Water is the root of life and the engine that drives agriculture, industry, economy and services. The demand for water often necessitates desalination, particularly in arid coastal environments where there are several desalination technologies in use today such as Multi-Effect Distillation (MED) and Reverse Osmosis (RO). The key utility requirement for technologies such as desalination and population in general include energy in one form or another. Therefore, desalination and co-generation are often integrated. Another key utility is electricity which is generated from either renewable or non-renewable sources. The demands for water and electricity change over time and are subject to …

Evolution And Equilibration Of Artificial Morphologic Perturbations In The Form Of Nearshore Berm Nourishments Along The Florida Gulf Coast, Katherine Emily Brutsché

USF Tampa Graduate Theses and Dissertations

Inlets and channels are dredged often to maintain navigation safety. It is beneficial to reintroduce the dredged material back into the littoral system, in the form of beach or nearshore nourishments. Nourishment in the nearshore is becoming an increasingly utilized method, particularly for dredged material that contains more fine sediment than the native beach. This research examines the morphologic evolution of two different nearshore nourishments. A nearshore berm was constructed at Fort Myers Beach, Florida using mixed-sized sediment dredged from a nearby channel. The nearshore berm was placed in water depths between 1.2 and 2.4 m with the berm crest …

Integrated Electrostatically- And Piezoelectrically-Transduced Contour-Mode Mems Resonator On Silicon-On-Insulator (Soi) Wafer, I-Tsang Wu

USF Tampa Graduate Theses and Dissertations

Due to the recent rapid growth in personal mobile communication devices (smartphones, PDA's, tablets, etc.), the wireless market is always looking for new ways to further miniaturize the RF front-ends while reducing the cost and power consumption. For many years, wireless transceivers and subsystems have been relying on high quality factor (Q) passives (e.g., quartz crystal, ceramics) to implement oscillators, filters, and other key RF front-end circuitry elements. However, these off-chip discrete components occupy large chip area and require power-demanding interfacing circuits. As a result, a great deal of research effort has been devoted to the development of …

Applying Modeled Hemi-Ellipsoids To The Study Of Pressure Distribution In Normal And Paraplegic Seated Subjects, Alicia Billington

USF Tampa Graduate Theses and Dissertations

The three goals of this research were to investigate how normal subjects move while seated, how paraplegic patients move while seated, and whether seated movements can be modeled using a hemi-ellipsoid shape. Pressure readings were recorded at 11 Hz using a 36 by 36 sensor pressure map by XSENSOR. Subjects were instructed to move or perform pressure relief as they normally would while seated. Analysis was performed using Microsoft Excel with Solver and Matrix.xla add-ins and automated with VBA code. Major movements and time intervals between movements were calculated by locating the area of maximum pressure on each hemi-buttock for …

Synthesis, Characterization And Mechanistic Studies Of Biomolecules@Mesomofs, Yao Chen

USF Tampa Graduate Theses and Dissertations

Encapsulation of biomolecules is of great interest to research advances related to biology, physiology, immunology, and biochemistry, as well as industrial and biomedical applications such as drug delivery, biocatalysis, biofuel, food and cosmetics. Encapsulation provides functional characteristics that are not fulfilled by free biomolecules and stabilizes the fragile biomolecules. In terms of biocatalysis, solid support can often enhance the stability of enzymes, as well as facilitate separation and recovery for reuse while maintaining activity and selectivity. Various kinds of materials have been used for encapsulation of biomolecules, among which, porous materials are an important group. Metal-organic frameworks (MOFs) have attracted …

Topological Data Analysis Of Properties Of Four-Regular Rigid Vertex Graphs, Grant Mcneil Conine

USF Tampa Graduate Theses and Dissertations

Homologous DNA recombination and rearrangement has been modeled with a class of four-regular rigid vertex graphs called assembly graphs which can also be represented by double occurrence words. Various invariants have been suggested for these graphs, some based on the structure of the graphs, and some biologically motivated.

In this thesis we use a novel method of data analysis based on a technique known as partial-clustering analysis and an algorithm known as Mapper to examine the relationships between these invariants. We introduce some of the basic machinery of topological data analysis, including the construction of simplicial complexes on a data …

Can The Usa National Weather Service Heat Index Substitute For Wet Bulb Globe Temperature For Heat Stress Exposure Assessment?, Ivory Iheanacho

USF Tampa Graduate Theses and Dissertations

Heat stress occurs when the body cannot adequately cool itself due to the combined contributions of metabolic heat, environmental factors and clothing. Heat stress found in the workplace puts employees at risk of developing heat-related illnesses, disorders and could be fatal. The wet bulb globe temperature (WBGT) index is the current method used to assess environmental contributions to heat stress in an occupational setting. The purpose of this thesis was to explore whether the National Weather Service's Heat Index (HI) could substitute for the WBGT Index during occupational heat stress exposure assessment. The possibility of using the HI for heat …