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The Role Of Dysregulation In Pediatric Obsessive Compulsive Disorder: An Examination Of Symptom Severity, Impairment And Treatment Outcome, Joseph F. Mcguire

USF Tampa Graduate Theses and Dissertations

Pediatric OCD is frequently complicated by co-occurrences with ADHD, mood and anxiety disorders. Although each of these disorders is associated with impaired self-regulation, there has been little examination of impaired self-regulation (i.e., dysregulation) in youth with OCD. Dysregulation is characterized by affective, behavioral and cognitive problems, and can be assessed using the Child Behavior Checklist-Dysregulation Profile (CBCL-DP). Dysregulation may help account for the varied yet related findings identified for symptom severity, impairment and treatment outcome in pediatric OCD. This study examined the role of dysregulation on symptom severity, impairment and treatment outcome in a large sample of youth with OCD. …

An Exploration Of Undeclared Students' Expectations Of Experiences For Faculty Interactions And Co-Curricular Involvement, Lorie Anne Kittendorf

USF Tampa Graduate Theses and Dissertations

Student persistence and achievement are areas of significant concern for institutions of higher education. With national college graduation rates hovering in the 50% range, it is important for colleges and universities to understand which student characteristics and campus environments lead to greater success, as well as the expectations students have of the college experience.

Research on undeclared students is vast and dates back more than 70 years, and many of the seminal studies and respected research data have led to the perception that they are at higher risk of attrition and have lower levels of academic achievement than their declared …

Hydrophilic Polymers Of Poly (2-Hydroxy Ethyl Methacrylate) With Tunable Properties For Drug Release, Sequestration Of Blistering Agent, Preparation Of Ultra-Strong Hydrogels & Thermal Stability Of Various Organic Azides, Ramakanth Ananthoji

USF Tampa Graduate Theses and Dissertations

The design and synthesis of new finely tunable porous materials has spurred interest in developing novel uses in a variety of systems. Zeolites, inorganic materials with high thermal and mechanical stability, in particular, have been widely examined for use in applications such as catalysis, ion exchange and separation. A relatively new class of inorganic-organic hybrid materials known as metal-organic frameworks (MOFs) has recently surfaced, and many have exhibited their efficiency in potential applications such as ion exchange and drug delivery. A more recent development is the design and synthesis of a subclass of MOFs based on zeolite topologies (i.e. ZMOFs), …

Predator-Based Fear Conditioning: A Novel Approach To The Study Of The Neurobiology Of Memory, Joshua D. Halonen

USF Tampa Graduate Theses and Dissertations

This series of experiments developed novel paradigms involving the integration of conventional and ethologically relevant forms of reinforcement in the study of fear conditioning in rats. Experiment 1 compared the effects of foot shock, immobilization and predator exposure, alone and in combination, on the expression of conditioned fear memory and extinction. The combination of all 3 reinforcers produced a significantly stronger fear memory and greater resistance to extinction, compared to when each reinforcer was administered alone. Furthermore, whereas conditioning with foot shock, alone, resulted in rapid extinction of the fear memory, the combination of immobilization and cat exposure, or all …

Enhancing The Immune Response Through Ikkbeta-Induced Activation Of Nf-Kappab, Emily Hopewell

USF Tampa Graduate Theses and Dissertations

Nuclear factor-κB (NF-κB) is one of the main regulators of inflammatory and immune responses. It is a family of transcription factors composed of five members: RelA, RelB, cRel, NF-κB1 (p105/p50), and NF-κB2 (p100/p52). Homo- and hetero-dimers of family members are inhibited by inhibitor of &klappaB (IκB) family members and activated by IκB kinase (IKK) family members. The IKK family is comprised of IKKα, IKKΒ, and IKKγ. The focus of my dissertation delves into the role of NF-κB activation by IKKΒ in both an immunotherapy setting and its role in T cell mediated anti-tumor immune responses.

A central focus of immunotherapy …

Protein Profiling Of Adenine Nucleoside And Nucleotide Analogs Binding Proteins Using N6-Biotinylated-8-Azidoadenosine Analogs As Affinity Based Protein Profiling Probes, Shikha Mahajan

USF Tampa Graduate Theses and Dissertations

Identification of differential expressions of proteins in proteomic profiles of biological samples shows great potential as a valuable technique for the early diagnosis of various diseases. An important challenge in modern protein profiling approaches is to reduce the complexity of the samples by limiting the number of proteins that need to be evaluated for distinction in the expression between normal and deceased cells. In this research, an affinity based approach for the enrichment of nucleotide and nucleoside binding proteins from a complex cell proteome has been developed. To achieve this goal, new N6-biotinylated-8-azido-adenosine probes (AdoRs) have been designed and synthesized …

Functional Magnetic Nanoparticles, James Gass

USF Tampa Graduate Theses and Dissertations

Nanoparticle system research and characterization is the focal point of this research and dissertation. In the research presented here, magnetite, cobalt, and ferrite nanoparticle systems have been explored in regard to their magnetocaloric effect (MCE) properties, as well as for use in polymer composites. Both areas of study have potential applications across a wide variety of interdisciplinary fields.

Magnetite nanoparticles have been successfully dispersed in a polymer. The surface chemistry of the magnetic nanoparticle proves critical to obtaining a homogenous and well separated high density dispersion in PMMA. Theoretical studies found in the literature have indicated that surface interface energy …

Regulation Of Natural Killer Cells: Ship-1, 2b4, And Immunomodulation By Lenalidomide, Nicole Renee Fortenbery

USF Tampa Graduate Theses and Dissertations

Natural Killer cells (NK) are critical components of the innate immune system. Often referred to by their morphology, these large granular lymphocytes (LGLs) are bone marrow-derived lymphocytes and can be found throughout the body. NK cells reside in the liver, lymph nodes, spleen, thymus, and mucosal-associated lymphoid tissues (MALT). Importantly, NK cells also circulate throughout the blood where they function as surveyors of the body and are armed to eliminate malignant, infected, damaged, or foreign cells.

NK cells function by a dual receptor system. That is, NK receptors are broadly categorized as inhibitory or activating. It is a fine balance, …

1-Deoxy-D-Xylulose-5-Phosphate Synthase (Dxs) Mechanistic Study And Its Implication In The Development Of Novel Antibiotics And Antimalarials, Sumit Handa

USF Tampa Graduate Theses and Dissertations

Isoprenoids are the largest family of biologically active compounds, synthesized by five carbon subunits namely isopentenyl pyrophosphate (IPP) and dimethylallyl pyrophosphate (DMAPP). For long time the mevalonate-dependent (MVA) pathway has been considered as the sole source of IPP and DMAPP, until recently a new non-mevalonte dependent (NMVA) pathway was discovered. This new pathway utilizes entirely different set of enzymes for isoprenoids synthesis and don't have any homologues in humans. NMVA pathway is the only source of isoprenoids for certain eubacteria, parasite and plants. Absence of the NMVA pathway in higher organisms has opened a new platform for the development of …

A Case Study Of Perspectives On Building School And Community Partnerships, Myrna Lee Hogue

USF Tampa Graduate Theses and Dissertations

A strong partnership between a school and the surrounding community leads to school success. Schools can be more successful with community involvement and engagement than if functioning in isolation. Community engagement leads to greater academic achievement of students.

Utilizing qualitative case study methods, this study focused on the perspective of school and community partners on building relationships. The purpose of this study was to describe and explain selected participants' perspectives on how a school builds partnerships with the community. I studied the relationship between an elementary school and community partners that have been in existence for at least three years …

Interrogating Grenadian Masculinities And Violence Against Women: An Evaluation Of The United Nations Partnership For Peace Program, Rohan Dexter Jeremiah

USF Tampa Graduate Theses and Dissertations

This applied anthropology study, guided by a feminist perspective and in particular, Black Feminist Thought is an outgrowth of an evaluation study of the Partnership for Peace Program (PFP) in Grenada, West Indies. The PFP is a Caribbean-specific model that was built into a sixteen-week cycle program by the United Nations Entity for Gender Equality and Empowerment of Women (UNWomen). Since 2005, the PFP has been geared towards Grenadian men, who have used violence against women to express their masculine identities. PFP focuses exclusively on rehabilitating male perpetrators with a goal to protect the human rights of women. This research …

Choice, Management, & Modification: Situational Context In Risky Choice, Nathaniel K. Decker

USF Tampa Graduate Theses and Dissertations

We sought to examine the potential differences between different types of risky decisions. While some decisions are easily represented as choices between future alternatives, other decisions may be better represented as the management of a personally owned situation. Schneider (2003) created the risk management task, which manifested these situated improvement decisions, and identified a unique pattern of risk preferences when compared to the standard gambling paradigm. To determine what cognitive processes might be differentially activated for each type of decisions so as to yield these risk preference differences, we incrementally manipulated the gambling paradigm to parse potentially influential elements of …

Low Level Exposure To Air Pollution And Risk Of Adverse Birth Outcomes In Hillsborough County, Florida, Maria B. Mainolfi

USF Tampa Graduate Theses and Dissertations

In this retrospective cohort from 2002 through 2007, 104,003 singleton live births in Hillsborough County, Florida were analyzed to elucidate the relationship between feto-infant morbidity outcomes and prenatal exposure to six criteria air pollutants. This study is based on three linked databases: The Florida Hospital Discharge database; The vital statistics records of singleton live births; Air Pollution meteorological data from the Environmental Protection Agency. There are six common air pollutants, particulate matter 2.5 (PM2.5), particulate matter 10 (PM10), ground-level ozone (O3), carbon monoxide (CO), nitrogen (NOx), and lead (Pb). These pollutants are harmful to human health and the environment. The …

Plant Species Richness And Species Area Relationships In A Florida Sandhill, Monica Ruth Downer

USF Tampa Graduate Theses and Dissertations

Pine sandhill are integral pyrogenic communities in the southeastern United States. Though once widespread, habitat destruction, fire suppression and fragmentation have reduced the population to nearly 3%. It is important to learn as much as possible about these unique areas in order to implement best management practices to conserve and restore the existing populations of these communities.

Fire is central to the maintenance of pine sandhill communities and two conceptual hypothesis regarding burn frequency have come to light in maintaining the unique species composition and richness of these areas. The first is the Intermediate Disturbance Hypothesis which suggests that intermediate …

Assessing The Microbial Consequences Of Remediation: Surrogate Microbial Screening And Native Metabolic Signatures In Tc(Vii) Contaminated Sediments, Kathryn Lafaye Bailey

USF Tampa Graduate Theses and Dissertations

The chemical and physical processes controlling contaminant fate and transport in the vadose zone limit the options for application of many remedial technologies. Foam delivery technology (FDT) has been developed as a potential solution to overcome these limitations for remediating subsurface and deep vadose zone environments using reactive amendments. Although there are many advantages to utilizing FDT for treatment in the deep vadose zone, little information is available on how the addition of these surfactants and remedial amendments affect the indigenous microbial communities in the deep vadose zone as well as the impact of biological transformations of surfactant-based foams on …

Valanced Voices: Student Experiences With Learning Disabilities & Differences, Zoe Dupree Fine

USF Tampa Graduate Theses and Dissertations

This feminist oral history project located at the intersections of disability, feminist, body politics, and educational theory presents an analysis of three individual student narratives about their experiences with learning disabilities and learning differences (LD/Ds) at the high school and university levels. This thesis introduces students' accounts of their daily lives, pasts, personal views, experiences, and memories about having learning disabilities and learning differences into the existing scholarship on LDs and reveals how students' narrated experiences might shed light on the ways in which education might be reformed to better meet the needs of students like them. In response to …

The Impacts Of Population Density, And State & National Litter Prevention Programs On Marine Debris, Melissa Rose Brogle

USF Tampa Graduate Theses and Dissertations

Marine debris is improperly disposed of solid waste, also called litter, which is deposited in the marine environment (NOAA, 2010). Litter prevention techniques such as fines, cleanups, incentives, and others, can help to decrease litter, and ultimately decrease marine debris. This research analyzed 2000 and 2010 International Coastal Cleanup (ICC) data obtained from The Ocean Conservancy to ascertain whether certain litter prevention techniques did reduce amounts and types of marine debris found in coastal areas. The litter prevention techniques analyzed included state bottle bills, voluntary monofilament fishing line recycling programs, and the Keep America Beautiful (KAB) cigarette butt litter prevention …

Critical Heat Stress Evaluation Of Two-Layer Clothing Ensembles And The Contributionof A Full-Face Negative Pressure Respirator, Oclla Michele Fletcher

USF Tampa Graduate Theses and Dissertations

Protective clothing ensembles are worn by workers as a barrier to chemical and physical hazards, but can restrict heat loss and increase worker heat stress. The question of whether a respirator adds to heat stress or strain burden is a continuing concern among occupational health professionals. The purpose of this study was to determine if there are differences in heat stress or strain among the current Toxicological Agent Protective (TAP) ensemble and two ensemble variations used in demilitarization of chemical weapons. Four acclimatized adult males wore five ensembles in a balanced design while walking in a climatic chamber at a …

The Impact Of Continuous And Discontinuous Cycle Exercise On Affect: An Examination Of The Dual-Mode Model, Sam Greeley

USF Tampa Graduate Theses and Dissertations

Low-volume, high-intensity interval training has been garnering attention in the exercise physiology literature recently due to its proposed time-efficiency. Also, recent work comparing continuous exercise to high-intensity interval training demonstrated superior ratings of perceived enjoyment following interval training. However, the dual-mode model suggests that exercise above ventilatory threshold (VT) done continuously will result in an almost homogenous decline in affect, which may reduce adherence.

Numerous studies confirm the dual-mode model's prediction of reduced affect when exercising above VT, but no research to date has applied the model's predictions to interval training. The purpose of this study was to examine the …

Assessing The Link Between Coastal Development And The Quality Of Fish Habitat In Mangrove Tidal Tributaries, Justin Micheal Krebs

USF Tampa Graduate Theses and Dissertations

To assess the potential influence of coastal development on the quality of estuarine habitat for nekton, we characterized land use and the intensity of land development surrounding small tidal tributaries of Tampa Bay. Based on this characterization, we classified tributaries as undeveloped, industrial, urban or man-made (i.e., mosquito-control ditches). Over one-third (37%) of tributaries were determined to be heavily developed, while fewer than one-third (28%) remain relatively undeveloped. We then examined the nekton community from eleven tributaries in watersheds representing the defined land-use classes. Whereas mean nekton density and species richness were both independent of land use, nekton-community structure differed …

Comparison Of Visual Vs. Microscopic Methods To Detect Blood Splatter From An Intravascular Catheter With Engineered Sharps Injury Protection (Esip), Aiysha R. Ansari

USF Tampa Graduate Theses and Dissertations

Intravascular devices with engineered sharps injury protection (ESIP) are designed to reduce sharps injuries, but have not been investigated for blood splatter potential. In this laboratory-based experiment, which did not use human subjects, 100 intravenous catheters of the same type with a retraction mechanism, were tested for blood splatter. Once blood was obtained from a simulated brachial vein containing mock venous blood, the devices were placed in a testing chamber and scientific filters labeled A, B & C were used to capture blood splatter after activation. The blood splatter was examined visually and microscopically, and the filters were weighed pre- …

Don't Blame It On My Ovaries: Exploring The Lived Experience Of Women With Polycystic Ovarian Syndrome And The Creation Of Discourse, Jennifer Lynn Ellerman

USF Tampa Graduate Theses and Dissertations

Polycystic Ovarian Syndrome (PCOS) is the most common endocrine disorder among females of childbearing age, affecting between 6-8% of the population. It is also the most common cause of infertility. Females with PCOS may have two or more of a constellation of symptoms that can potentially leave them at odds in terms of normative ideals of femininity. This study examines how feminist theory interrogates and analyzes knowledge about the body and PCOS, integrating the lived experiences of women to provide a deeper, more meaningful understanding of what it means to be a woman with PCOS.

"You Have To Have Children To Be Happy:" Exploring Beliefs About Reproduction With Burmese Refugee Women In The United States, Kara E. Mcginnis

USF Tampa Graduate Theses and Dissertations

Burmese refugees are entering the US at record speed. Resettlement agencies focus on immediate needs, and ethnic community-based organizations (ECBOs) fill any service gaps through community-driven programs. The Tampa Bay Burmese Council (TBBC) is an ECBO in Tampa, FL dedicated to the Burmese community. This research explores the reproductive beliefs of the women in the community, paying particular attention to any differences that arise due to beliefs specific to their ethnic group. Findings include the importance of menses for women's health, the preference for both male and female children, a lack of knowledge about family planning methods, a tendency to …

Development Of A Tool For Pressure Ulcer Risk Assessment And Preventive Interventions In Ancillary Services Patients, Monica Shutts Messer

USF Tampa Graduate Theses and Dissertations

The incidence of nosocomial pressure ulcers has continued to increase in U.S. hospitals over the past 15 years despite the implementation of national preventive guidelines and the wide-spread use of validated risk assessment tools. The majority of preventive efforts and tools have been focused primarily on patients who are bed-ridden or immobile for extended periods. What has not been well studied or identified is the potential risk for pressure injury to patients undergoing diagnostic procedures in hospital ancillary units where extrinsic risk factors such as high interface pressures on procedure tables and friction and shear from positioning and transport can …

Testing A Model Of Bacterial Vaginosis Among Black Women, Jessica Brumley

USF Tampa Graduate Theses and Dissertations

Bacterial Vaginosis is an inbalance of vaginal flora which has been associated with increased risk of numerous gynecological and obstetric morbidities including increased risk of acquisition of HIV from an infected partner and increased risk of preterm delivery. Black race has been consistently identified as a risk factor for BV. Black women also suffer from significant disparities in most of the morbidities also associated with BV when compared to women of other ethnicities and races. Traditional predictors of BV such as douching practices and sexual behaviors do not fully account for the racial disparities in BV prevalence. Researchers have begun …

Overcoming Adversity: Resilience Of Low-Income, Nonresidential, Black Fathers, Erica Elizabeth Coates

USF Tampa Graduate Theses and Dissertations

Objective. This study examined the factors associated with higher levels of paternal involvement among low-income, nonresidential, Black fathers. Method. Participants were 110 fathers of children up to the age of 10. Participants completed psychometrically sound measures of social support, spirituality, family of origin relationships, coparenting relationship quality, psychological well-being, motivation, conviction history, resilience, and father involvement. Results. A simultaneous multiple regression indicated that better psychological well-being and coparenting relationship quality and lower conviction rates since the birth of the child were significant predictors of higher levels of paternal involvement. Mediational analysis revealed that coparenting relationship quality partially mediated the relationship …

Goal Attainment As A Function Of Depressive Status In Women: The Role Of Problem-Solving, Lindsay Brauer

USF Tampa Graduate Theses and Dissertations

Despite the theoretical importance of goal-related deficits in individuals with Major Depressive Disorder (MDD), relatively empirical research has examined goal generation and perceived goal attainment in depression vulnerable individuals. The

current project sought to examine the impact of depressive status on perceived goal attainment in currently depressed, remitted depressed, and never-depressed women. In addition, perceived problem-solving skills, a construct thought to be critical for goal

striving and in goal attainment was also examined. Unexpectedly, no effects of depressive status on perceived goal attainment or overall perceived problem-solving skills were observed. Results did however reveal group differences in perceived control in …

Rainwater Harvesting Storage Methods And Self Supply In Uganda, Jonathan Peter Blanchard

USF Tampa Graduate Theses and Dissertations

Self supply is an emerging approach to water supply which focuses on fostering household investment in incremental improvements to their water sources. When successful, it can lower costs and increase sustainability by offering users a larger share

of ownership in their own supply, and harnessing the already existing strengths of a community rather than trying to impose an external perspective. In addition to well upgrading and source protection, one of the key self supply areas is rainwater harvesting.

Uganda has a diverse selection of rainwater storage options, but many of them are scattered and disparate.

The objective of this study …

A Systematic Review Of Interventions To Increase Mental Health Service Use, Jennifer Greene

USF Tampa Graduate Theses and Dissertations

Relatively few pre-treatment interventions to increase out-patient mental health (MH) service use have been created and experimentally tested. Therefore, not only is there limited availability of these interventions, it is uncertain whether existing interventions are effective. Moreover, it is unclear which components of the interventions are effective. To address these gaps in knowledge, a systematic review of pre-treatment interventions was conducted, using the Cochrane Review methodology. Three primary outcomes were evaluated: attendance at any type of out-patient MH visit; number of appointments of any type of out-patient MH visit; and/or initiation and adherence to psychotropic medication. PubMed and PsycINFO databases …

An Examination Of Self-Directed Learning Readiness In Executive-Level Fire Officers, Steven G. Knight

USF Tampa Graduate Theses and Dissertations

The purpose of this study was to examine the self-directed learning readiness in executive fire officers in relation to the independent variables of personality type, educational attainment, and professional designation. This research utilized a quantitative design.

This study utilized the Myers-Briggs Type Indicator (MBTI) and the Self-Directed Learning Readiness Scale (SDLRS) with a sample of 250 professional firefighters. The total sample was divided equally between executive-level fire officers and firefighters at 125 each from professional departments in the Southeastern United States. Results were that the mean SDLRS score for the executive-level fire officers was 233.7 and significantly higher than the …