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How Mature Capitalism Turns Pollution Into Diamonds: Malagnogenesis And The Reverse-Engineering Of Harm Into Risk, Kevin P. Martyn

USF Tampa Graduate Theses and Dissertations

In recent years, there has been a great deal of debate about the pervasiveness and persistence of neoliberal thinking. In the context of the post-2008 ‘great recession’ the resilience of neoliberalism is particularly confounding. To begin to unravel the ways in which neoliberalism is situated relative to risk, this study identifies an increasingly important neoliberal knowledge practice: malagnogenesis. Malagnogenesis is proposed herein as the production of ignorance that normalizes harm for and amongst marginalized populations. To shed light on the phenomena of malagnogenesis, this study investigated the history of leaded gasoline in the U.S. To that end, I …

Importance Of Forest Structure For Amphibian Occupancy In North-Central Florida: Comparisons Of Naturally Regenerated Forests With Planted Pine Stands, Christopher J E Haggerty

USF Tampa Graduate Theses and Dissertations

Once dominant, longleaf pine forests of the southeastern United States have been modified by 97 percent, resulting in several animal species being listed as endangered and threatened. Pine plantation silviculture (tree plantings) now occupies half of the original longleaf range where several animal species of conservation concern have experienced recent local population declines. In North America, the accepted practice of pine plantations is to plant pines densely in rows for wood production. Given that land use is considered a primary local driver for the 30% of amphibian species currently at risk of extinction, and planted pine is predicted to expand …

Design And Development Of Peptidomimetic Ligands For Targeting Radiopharmaceuticals, Imaging Probes, And Immunotherapeutics In Oncologic Disease, Michael Lawrence Doligalski

USF Tampa Graduate Theses and Dissertations

Cancer is a leading cause of morbidity and mortality in the developed world. While much has been learned about these diseases in the last few decades, one of the main barriers to widespread advancement is the heterogeneity of cancer biology. A growing body of evidence supports the idea that certain protein receptors are overexpressed on the surface of tumor cells as compared to normal tissues. These extracellular biomarkers provide a unique opportunity to selectively target the tumor with both imaging and therapeutic modalities. The research in this dissertation focuses on targeting proteins on the tumor cell surface with peptidomimetic ligands. …

Feeding Patterns And Trophic Food Web Dynamics Of Armases Cinereum Across A Mangrove/Upland Ecotone, Erin Paige Kiskaddon

USF Tampa Graduate Theses and Dissertations

The feeding ecology of a common saltmarsh crab, Armases cinereum (Armases), was investigated to determine how habitat (mangrove vs. ecotone, natural mangrove vs. modified mangrove fringe) influenced this species’ feeding behavior and trophic ecology in its southwestern Florida, USA, distribution. In the laboratory, Armases’ preference for mangrove material was examined using leaves of three mangrove species (Avicennia germinans, Laguncularia racemosa, and Rhizophora mangle) and leaves of different degradation levels (fresh, senescent, and partially-decomposed). Leaf material from A. germinans was preferentially consumed over the other taxa at fresh and partially-decomposed levels of leaf decay. When Armases were …

Regulation Of Nachrs And Stemness By Nicotine And E-Cigarettes In Nsclc, Courtney Schaal

USF Tampa Graduate Theses and Dissertations

Lung cancer is the leading cause of cancer-related death in both men and women, nationally and internationally and kills more people each year than breast, prostate, and colon cancers combined. Non-small cell lung carcinoma (NSCLC) is the most common histological subtype of lung cancer, and accounts for 85% of all cases. Cigarette smoking is the single greatest risk factor for lung cancer, and is correlated with 80-90% of all lung cancer deaths. Nicotine, the addictive component of tobacco smoke, is not a carcinogen and cannot initiate tumors itself; however, it is known to act as a tumor promoter, by enhancing …

Branding Implications Of Co-Created Social Responsibility, Alexander J. Kull

USF Tampa Graduate Theses and Dissertations

One of the most profound transformations of the marketing discipline in recent history has been driven by the democratization of power relations and value creation between brands and consumers. This dissertation explores the branding implications of this fundamental shift by investigating whether and how the type and degree of control shared by brands affect consumer empowerment perceptions and, in turn, consumer–brand relationships, as well as whether and how these effects might be moderated by the size and diversity of the choice set and by the image valence of the brand that shares control with consumers.

The present research examines such …

Moderation Analysis Of Bowel Function Among Nutrients And Physical Function Or Depression, As Well As Whether Bowel Function Is Related To Cognition In Older Adults, Jessie Alwerdt

USF Tampa Graduate Theses and Dissertations

As we age, the risk for gut issues, such as smooth muscle tone, may be an underlying indirect or direct cause or risk factor for many age-related issues, such as frailty. Consequences of decreased motility and depleted epithelial barrier may result in nutrient deficiencies that may increase the risk for malnutrition (Brownie, 2006). Further, there is increasing evidence that there is a gut-brain-axis relationship that may influence cognition and mental health issues, such as depression and anxiety. While there are relationships established, the interconnections of these factors have yet to be fully understood.

This dissertation examined several relationships specific to …

Antimalarial Exoerythrocytic Stage Drug Discovery And Resistance Studies, Lynn Dong Blake

USF Tampa Graduate Theses and Dissertations

Malaria is a devastating global health issue that affects approximately 200 million people yearly and over half a million deaths are caused by this parasitic protozoan disease. Most commercially available drugs only target the blood stage form of the parasite, but the only way to ensure proper elimination is to treat the exoerythrocytic stages of the parasite development cycle. There is a demand for the discovery of new liver stage antimalarial compounds as there are only two current FDA approved drugs for the treatment of liver stage parasites, one of which fails to eliminate dormant forms and the other inducing …

Computational Modeling Of Allosteric Stimulation Of Nipah Virus Host Binding Protein, Priyanka Dutta

USF Tampa Graduate Theses and Dissertations

Nipah belongs to the family of paramyxoviruses that cause numerous fatal diseases in humans and farm animals. There are no FDA approved drugs for Nipah or any of the paramyxoviruses. Designing antiviral therapies that are more resistant to viral mutations require understanding of molecular details underlying infection. This dissertation focuses on obtaining molecular insights into the very first step of infection by Nipah. Such details, in fact, remain unknown for all paramyxoviruses. Infection begins with the allosteric stimulation of Nipah virus host binding protein by host cell receptors. Understanding molecular details of this stimulation process have been challenging mainly because, …

Development Of A Decentralized And Off-Grid Anaerobic Membrane Bioreactor (Anmbr) For Urban Sanitation In Developing Countries, Robert Alonso Bair

USF Tampa Graduate Theses and Dissertations

Urbanization has led to rapid and uncontrolled growth of informal housing settlements in many developing countries. As most slum growth is unplanned, these areas tend to lack basic infrastructure including sanitation. The high user rates, lack of water and electricity infrastructure, space limitations, and scant financial resources make sanitation provision a major challenge in slums. As most decentralized sanitation technologies fail when applied in these environments, better technologies need to be developed that cater to the specific needs of slum dwellers. One promising technology, the membrane bioreactor (MBR) is routinely used in developed countries when a compact and resilient treatment …

Drivers Of Immune Cost And Implications For Host Protection From Parasites, Amber Jasmine Brace

USF Tampa Graduate Theses and Dissertations

Among species, populations, and individuals, there exists a tremendous amount of variation in how hosts respond to, and are thus protected from parasites. Such variation inevitably affects host-parasite dynamics and ultimately how parasites will move through and evolve in communities. A likely factor in the diversity of immune responses seen in nature are the costs associated with activation of the immune system upon exposure to parasites. Costs can manifest in many ways, including changes in resource usage or metabolism, self-damage from inflammatory reactions, lost opportunities (e.g., foraging reproduction), and often as tradeoffs with other physiological processes. However, we do not …

Monitoring And Mitigation Of Elevated Co2 Impacts Using Microalgae, Terry-Rene Wiesner Brown

USF Tampa Graduate Theses and Dissertations

Climate change is arguably the greatest environmental and economic challenge of our time. There are considerable documented and projected impacts to both human and natural systems as a result of climate change. These impacts include changes in temperature, sea level, precipitation patterns, and biogeography of ecologically and economically relevant species, including pathogens. One of the main drivers of climate change is elevated levels of atmospheric carbon dioxide (CO₂), a greenhouse gas. Since pre-industrial times, atmospheric CO₂ levels have increased from approximately 280 ppm to over 400 ppm, as a result of fossil fuel combustion, cement production and …

Teacher Child Interaction Therapy: An Ecological Approach To Intervening With Young Children Who Display Disruptive Behaviors, Sara Marie Hinojosa

USF Tampa Graduate Theses and Dissertations

A model of Teacher Child Interaction Therapy (TCIT) was implemented in two kindergarten classrooms of students (n = 2) who successfully completed Parent Child Interaction Therapy, but continued to demonstrate disruptive behaviors in the classroom. The current study first indicated that TCIT was implemented with integrity by both the therapists and teacher participants. Next, the effects of this intervention on the teacher’s skills, students’ disruptive behaviors, teacher’s stress, and teacher-child relationships were investigated. The treatment acceptability was also examined. Both visual and statistical analyses found a treatment effect in both cases was seen for both teachers’ increased use of positive …

The Applicability Of Criminology To Terrorism Studies: An Exploratory Study Of Isis Supporters In The United States, Amanda Marie Sharp Parker

USF Tampa Graduate Theses and Dissertations

In the years following the 11 September 2001 attacks, research in the area of terrorism expanded exponentially. However, the changing nature of terrorism and lack of available data make it a difficult topic for criminologists to study; as academics we do not have access to the governmental data and data that is publicly available is often restricted due to the sensitive nature of national security issues. As first hand data is not available, an alternate data source, court records, may provide insight to the profile of current terrorists/terrorist supporters in the United States. Using court data from 71 cases of …

“Black Americans And Hiv/Aids In Popular Media” Conforming To The Politics Of Respectability, Alisha Lynn Menzies

USF Tampa Graduate Theses and Dissertations

This dissertation examines narratives about racialized gender, sexuality, and class through media images of black Americans with HIV/AIDS. Through textual analysis of media sites featuring HIV/AIDS and blackness (The Announcement, Precious, and Marvelyn Brown’s website, www.marvelynbrown.com), this project analyzes how the politics of respectability—a set of precepts that govern how black men and women can present themselves in public spaces to align with white ideals of gender and sexuality—construct black people in media representations of HIV/AIDS. This work examines how respectability politics deployed in media representations of HIV/AIDS and black Americans reclaim notions of acceptable black sexuality …

A Caenorhabditis Elegans Model To Detect Developmental Teratogens With Adverse Reproductive And Metabolic Effects, Alexis Ann Killeen

USF Tampa Graduate Theses and Dissertations

Obesity is a current epidemic in the United States. Greater than one third of adults and nearly one fifth of children are classified as obese (Ogden, 2014). Increased awareness of this problem has triggered interest into the potentially causal agents in our environment. These agents, termed obesogens, are a type of teratogen hypothesized to work during embryonic development by programming offspring to store excess fat. A type of teratogen, obesogens are also typically reprotoxic, affecting germline development and embryonic viability. These noxious teratogens span a variety of different chemical classes including estrogen mimics, metals and metalloids, biocides, and even voluntary …

The Concerted Regulation Of Intracellular Signaling By Amyloid Precursor Protein And Aβ Peptide, Lisa Kirouac

USF Tampa Graduate Theses and Dissertations

It is widely accepted that A-beta (Aβ) generated from amyloid precursor protein (APP) oligomerizes and fibrillizes to form neuritic plaques in the Alzheimer’s disease (AD) brain, yet little is known about the contribution of APP preceding AD pathogenesis. Our data presented here suggest that APP has a functional role in cell cycle regulation and proliferation. First, we demonstrat that APP is pathologically phosphorylated at Thr₆₆₈ and that P-APP localizes to the centrosomes. Furthermore, P-APP is proteolytically processed in a cell cycle -dependent manner to generate its pathogenic metabolites. Using Stable Isotope Labeling by Amino Acids in Culture (SILAC) and …

Making A Place For People At A Wildlife Corridor On Chicago's South Side, Alexis Winter

USF Tampa Graduate Theses and Dissertations

What role do environmental conservation projects play in the transformation of American cities? How do these projects affect city residents? In this study, I ask these questions at the Burnham Wildlife Corridor, where the Chicago Park District worked with institutional and community-based partner organizations to engage city residents in the creation of a lakefront wildlife habitat and public nature area. Through ethnographic interviews and participant observation I explored how actors at various levels understand this changing landscape and their roles in shaping it. I situate the Burnham Wildlife Corridor project in the broader context of a state-level plan, the Millennium …

Photic Stress In Symbiont-Bearing Reef Organisms: Analyses Of Photosynthetic Performance, Natasha Mendez-Ferrer

USF Tampa Graduate Theses and Dissertations

Photo-oxidative stress is one of the key factors that can induce bleaching in reef organisms. With the decline of coral reefs and recurrent bleaching events, many studies have focused on understanding the mechanism behind this phenomenon. Two of the hypotheses that explain how the photosynthetic performance of the symbiont is affected and influences bleaching are: (1) disruption of the photosynthetic pathway by direct damage to the photosystem II (PSII), and (2) by inhibition of the Calvin-Benson cycle. In this dissertation I examine different aspects of photosynthetic performance in symbiont-bearing reef organisms and how this is influenced by symbiont loss and …

Using Instructions And Behavioral Skills Training To Teach Facebook Skills To Seniors, Alison Ann Oconnell

USF Tampa Graduate Theses and Dissertations

The senior population is growing faster than any other population group, and life expectancy is increasing. E-mail and social media enable people of all ages to stay in touch, and find information, resources, and entertainment. Positive effects are associated with computer and internet use for older adults, but not all seniors have embraced technology and some seniors feel negatively about it. Several different methods have been used to teach seniors computer skills, including mentoring, lecturing, and providing instructions, but not many procedures have been evaluated for effectiveness. In the current study, we recruited three to five seniors, taught them to …

The Effect Of Home Range Estimation Techniques On Habitat Use Analysis, Brendon Quinton

USF Tampa Graduate Theses and Dissertations

The term “home range” refers to the area in which an animal spends most of its time during everyday activities. This study examined the effects of four different home range estimation techniques on the proportions of habitats located therein. The study utilized a point dataset collected for twenty individual Florida Black Bears (Ursus americanus floridanus), occurring in five different areas throughout the state of Florida. Each dataset was used to create home ranges using the following techniques: (1) Minimum Convex Polygon, (2) Kernel Density Estimation, (3) Characteristic Hull Polygon, and (4) Time-Geographic Density Estimation, a new home range …

Respiratory Syncytial Virus-Infected Mesenchymal Stem Cells Regulate Immunity Via Interferon-Beta And Indoleamine-2,3-Dioxygenase, Michael B. Cheung

USF Tampa Graduate Theses and Dissertations

Respiratory syncytial virus (RSV) is the most common cause of acute lower respiratory tract infection in young children worldwide, accounting for an estimated 33.8 million cases of respiratory disease, over 3 million of which require hospitalization, and between 66,000 and 199,000 deaths in this susceptible population. Additionally, severe RSV infection early in life is associated with an increased risk of wheeze and other airway disorders later in life. Despite this, there is currently no vaccine or economically reasonable prophylactic regimen to prevent infection. While disease is typically more severe in infancy RSV can infect throughout the lifespan repeatedly as the …

Sialylation And Cardiomyocyte Complex N -Glycosylation Protect Against Dilated Cardiomyopathy And Heart Failure, Wei Deng

USF Tampa Graduate Theses and Dissertations

Dilated cardiomyopathy (DCM) is the third most common cause of heart failure, often associated with arrhythmias and sudden cardiac death if not controlled. Metabolic and/or environmental factors, such as alcohol abuse, obesity, diabetes and Chagas disease, alter glycoprotein glycosylation, can lead to DCM. Inherited genetic disease, such as the human congenital disorders of glycosylation (CDG), causes multi-system manifestations including DCM. Non-congenital changes in glycosylation are also occurred in humans with and in animal models of DCM and heart failure. However, mechanisms responsible for glyco-dependent DCM are not understood. Here we sought to investigate the impact of sialylation and N-glycosylation …

The Psychometric Evaluation And Validation Of A Measure Assessing Pharmacological And Social Alcohol Expectancies In Adolescents, Megan Victoria Mcmurray

USF Tampa Graduate Theses and Dissertations

Extending prior alcohol expectancy measurement research, this researcher (McMurray, 2013) recently developed the Pharmacological and Social Alcohol Expectancy Scale (PSAES). The PSAES is the only alcohol expectancy measure to date that provides adequate coverage of both social expectancies and the anticipated positive pharmacological effects resulting from alcohol consumption, and was developed and validated in a sample of young adults (aged 18-23). Research has shown that adolescents at high risk for alcohol use disorder (AUD) hold higher expectations of reward from alcohol, suggesting that expectancy patterns may help distinguish at-risk youth. Building upon the previous PSAES validation study, the primary purpose …

What’S In Your Toolbox? Examining Tool Choices At Two Middle And Late Woodland-Period Sites On Florida’S Central Gulf Coast, Lori L. O'Neal

USF Tampa Graduate Theses and Dissertations

The examination of the tools that prehistoric people crafted for subsistence and related practices offers distinctive insights into how they lived their lives. Most often, researchers study these practices in isolation, by tool type or by material. However, by using a relational perspective, my research explores the tool assemblage as a whole including bone, stone and shell. This allows me to study the changes in tool industries in relation to one another, something that I could not accomplish by studying only one material or tool type. I use this broader approach to tool manufacture and use for the artifact assemblage …

Diversity And Distribution Of Diatom Endosymbionts In Amphistegina Spp. (Foraminifera) Based On Molecular And Morphological Techniques, Kwasi H. Barnes

USF Tampa Graduate Theses and Dissertations

Diatoms associated with foraminifers of the genus Amphistegina were assessed using a combination of morphological and molecular techniques. These included: 1) microscopic identification of diatoms cultured from the host, 2) sequencing of portions of the small subunit of the ribosomal RNA gene (18S) and the large subunit of the ribulose-1,5-bisphosphate carboxylase/oxygenase [i.e., RubisCO] gene (rbcL) from DNA extracted directly from the Amphistegina hosts and also from diatoms cultured from these hosts, and 3) denaturing gradient gel electrophoresis (DGGE) profiles of rbcL and internal transcribed spacer 1 (ITS1) PCR amplicons from DNA extracted directly from …

From Tolerance To Transmission: Linking Within-Individual To Community-Level Disease Processes, Sarah Catherine Burgan

USF Tampa Graduate Theses and Dissertations

Hosts have two main strategies for coping with infections: resistance and tolerance. Resistance is aimed at preventing or eliminating parasites, whereas the goal of tolerance is to maintain performance regardless of parasite burden. The balance between resistance and tolerance within a host may mediate host competence, or the propensity of a host to infect other hosts or vectors. Hosts with high tolerance and low resistance to an infection, for instance, may be highly competent and possess the greatest potential to act as superspreaders. These superspreading hosts will contribute disproportionately to transmission, thus posing the greatest risk to other hosts within …

Tunable Nano-Delivery System For Cancer Treatment: A New Approach For Targeted Localized Drug Delivery, Rana Falahat

USF Tampa Graduate Theses and Dissertations

Localized drug delivery systems have been widely studied as potential replacements for conventional chemotherapy with the capability of providing sustained and controlled drug release in specific targeted sites. They offer numerous benefits over conventional chemotherapy such as enhancing the stability of embedded drugs and preserving their anticancer activity, providing sustained and controlled drug release in the tumor site, reducing toxicity and diminishing subsequent side effects, minimizing the drug loss, averting the need for frequent administrations, and minimizing the cost of therapy.

The aim of this study is to develop a localized drug delivery system with niosomes embedded in a chitosan …

Social Dynamics And Ceramic Mobility Of Final Bronze Age Ceramics In Corsica (France): Elemental Analysis Using A Portable X-Ray Fluorescence Spectrometer, Aurelien Tafani

USF Tampa Graduate Theses and Dissertations

The Corsican Bronze Age is characterized by the erection of massive stone towers, the torre, and of stone enclosures, the casteddi. While the role of these structures is still debated, they have generally been interpreted as the sign of a hierarchical society, pervaded by martial values and fragmented into competing antagonistic groups. After several centuries of stability, a sharp demographic decline occurred at the end of the Middle Bronze Age. ca. 1350 and 1200 BC. In contrast, the Final Bronze Age, between 1200 and 950 BC, is a period of continuous expansion, characterized by the appearance of new …

Smoking Among Youth Living With Hiv: The Intersection Of Behavioral Health And Chronic Disease, Todd Wells

USF Tampa Graduate Theses and Dissertations

Smoking amongst youth living with HIV (YLWH) has major public health implications. When combined with the complications associated with smoking such as chronic obstructive pulmonary disorder (COPD) or heart disease, the impact of a HIV positive diagnosis increases morbidity exponentially (Nahvi & Cooperman, 2009). The purpose of this study was two-fold, to investigate the perceptions of smoking amongst YLWH aged 18-25 who received care at the CMS Clinic located at the University of South Florida and to determine factors related to cessation. A study design utilizing two components, a systematic literature review and primary qualitative data was used in this …