Digital Commons Network^™

Black Males’ Experiences Of Resilience: A Narrative Study On College Students Experiences During The Covid-19 Pandemic, Keshia R. Graham

Theses and Dissertations

Black men’s resilience has historically been discussed, interwoven, and disguised by deficit-based models rather than strength-based ones. The current study examined Black men's resilience using a strength-based model for Black male students in higher education institutions. Specifically, the experiences and resilience of Black men before and during the COVID-19 pandemic were explored. This study targeted Black male students from an urban institution, with the aim to find out what key elements supported their resilient behavior throughout the most challenging times in their college career. The African American Male Theory and Resiliency Theory used as the theoretical framework. A narrative methodology …

Unlocking Simulation Modeling Proficiency: Ai As A Key To Autonomous Expertise Development, Esha Bhadoriya

Theses and Dissertations

This study addresses challenges in Discrete Event Simulation (DES) education, where traditional methods focus heavily on theory but lack hands-on, real-world application. To bridge this gap, the research explores using AI, specifically GPT models, to create interactive, accessible learning experiences in DES. By comparing structured and unstructured questioning approaches, the study demonstrates that structured interactions using a Work Breakdown Structure (WBS) produce more accurate, realistic DES models. Findings show that structured AI-driven methods help learners better understand and apply DES concepts, providing a practical pathway from theory to application. This research highlights AI’s potential to transform DES education, supporting diverse …

Adaptive Multi-Label Classification On Drifting Data Streams, Martha Roseberry

Theses and Dissertations

Drifting data streams and multi-label data are both challenging problems. When multi-label data arrives as a stream, the challenges of both problems must be addressed along with additional challenges unique to the combined problem. Algorithms must be fast and flexible, able to match both the speed and evolving nature of the stream. We propose four methods for learning from multi-label drifting data streams. First, a multi-label k Nearest Neighbors with Self Adjusting Memory (ML-SAM-kNN) exploits short- and long-term memories to predict the current and evolving states of the data stream. Second, a punitive k nearest neighbors algorithm with a self-adjusting …

Variability In Perceptions Of Complementary Health Approaches Among Graduate Student Trainees, Delaney C. Bilodeau

Theses and Dissertations

Complementary Health Approaches (CHAs) encompass a diverse range of practices which are often used both independently and alongside conventional medical treatments. Understanding how graduate students training in different fields perceive CHAs is important because these professional trainees will go on to occupy roles as healthcare practitioners, researchers, policy makers, and consumers. This study used sequential rank agreement methods (Ekstrøm, Gerds, & Jensen, 2019) to investigate variations in perceptions of CHAs in a sample of graduate students (N = 416) from 140 possible training programs. Ratings of CHA familiarity, perceptions of CHA legitimacy, and willingness to recommend CHAs were compared …

Humans Are Dust, Chelsea Nanfelt Rowe

Theses and Dissertations

I probe how objects act as intermediaries between people. These explorations reflect on the delicate navigation that happens when we intertwine our lives with others. My curiosities lie in the fuzzy aura of human life that encircles materials. Do our materials possess life or do we imbue and inject the materials in our world with personalities reflective of ourselves? My motivation for this project is to highlight the stories infused in and witnessed by things we surround ourselves with and use daily.

Investigating The Ultrafast Dissociation Dynamics Of Energetic Materials Using Femtosecond Time-Resolved Mass Spectrometry, Jacob M. Shusterman

Theses and Dissertations

Shock initiation of energetic materials produces cations and anions that can contribute to initial endothermic chemical reactions which lead to detonation. Hence, knowledge of the initial dissociation pathways of ionized energetic molecules is important for advancing the understanding of initiation mechanisms and meeting longstanding goals of the Department of Defense. Despite their potential importance, these transient charged species are difficult to detect in detonation experiments and are often ignored in molecular dynamics modeling of shocked energetic materials. However, the technique of pump-probe femtosecond time-resolved mass spectrometry (FTRMS) paired with complementary theoretical calculations can be used to elucidate initial unimolecular dissociation …

Exploring Factors Influencing The Adoption Of Ai Tools In Auditing: A Mixed-Methods Study, Fahad Alsudairi

Theses and Dissertations

Artificial Intelligence's (AI) rise has created value for organizations and society, prompting scholars to study its spread across many areas. However, the impact of AI adoption on governmental organizations still needs to be explored. Governmental entities face unique challenges distinct from private organizations, and existing research often focuses on the perspectives of AI experts or senior management, neglecting the insights of lower-level employees who will use the system daily.

This study investigates the multifaceted factors influencing the intention to adopt AI tools within a governmental auditing bureau in Saudi Arabia. To the best of our knowledge, no previous study has …

Investigation Of Brain Function And Structural Development As Risk Factors Of Suicidal Thoughts And Behaviors, Yi Zhou

Theses and Dissertations

Background: Identifying risk factors for suicidal thoughts and behaviors, especially causal ones, will be imperative to improving screening and treatment interventions. To identify replicable brain-based risk factors, there is increasing evidence indicating the need for large sample sizes, in the hundreds to thousands, in order to achieve a sufficient level of statistical power to detect them. Furthermore, longitudinal studies of brain and behavioral factors will be essential to understanding how suicide develops, especially the transition from suicide ideation to attempt. While experimental studies may not be feasible or ethical, genetically informed methods for testing evidence for causation are an alternative …

Stealthy Control Logic Attacks And Defense In Industrial Control Systems, Adeen Ayub

Theses and Dissertations

Industrial control systems (ICS) play a crucial role in monitoring and managing critical infrastructure, including nuclear plants, oil and gas pipelines, and power grid stations. Programmable logic controllers (PLCs) are a fundamental component of ICS, directly interfacing with physical processes and implementing control logic programs that govern operations. Due to their significance in controlling critical infrastructure, PLCs often become prime targets for attackers seeking to disrupt these systems. Exploitable vulnerabilities in PLCs render them susceptible to such attacks. While many attacks on PLCs leave a large footprint in network traffic and are detectable by intrusion detection systems (IDS), this dissertation …

Transitions In Patterns Of Substance Use During Early Adolescence: Bidirectional Associations With Externalizing Behaviors, Courtney B. Dunn

Theses and Dissertations

Early adolescents who engage in polysubstance use, defined as the use of three or more different substances, are at particularly high risk of future substance use disorders and adverse psychosocial outcomes. However, little is known about the development of substance use patterns during early adolescence, particularly among youth living in urban settings. Although theory and research suggest that youth with greater externalizing behaviors (e.g., aggression, delinquent behavior) may be more likely to escalate to polysubstance use at an early age, few studies have examined bidirectional relations between externalizing symptoms and polysubstance use. The goal of this study was to (a) …

Supported Metal Nanoparticle Synthesis: Precursor Deposition And Agglomeration At Support Surfaces, Edward H. Chandler Jr.

Theses and Dissertations

Catalysis is a critical component of the chemical manufacturing industry. For example, it has been estimated to be essential to more than 90% of the major industrial processes developed during the middle years of the 20^th century.¹ Heterogeneously supported transition metal catalysts in particular have many benefits such as easy separability from the reaction mixture and high thermal stability. One method of synthesizing these is wet impregnation, wherein a metal solution is brought into contact with an oxide- or carbon-based powder. Given optimal environmental conditions, a metal will adhere to the surface through electrostatic means in a process …

Prosthetic Attention In Upper Limb Loss: User Experiences, Clinical Perceptions, And Developing Candidate Items, Tanu Bhargava

Theses and Dissertations

The human hand is a powerful tool essential for performing a range of tasks from simple to complex, and it plays a crucial role in social interactions and environmental engagement. Upper limb (UL) loss disrupts these functions and significantly impacts daily life. Prosthetic devices can partially restore these abilities and improve quality of life, but they lack the intuitive control and sensory feedback of natural hands. Consequently, operating a UL prosthesis requires substantial attentional demands, a factor that potentially contributes to high rates of device dissatisfaction and disuse. For UL prosthesis users, managing attentional resources is critical to efficiently controlling …

Functional Family Therapy: A Multi-Year Statewide Program Evaluation, Natalie Finn

Theses and Dissertations

Functional Family Therapy (FFT) is a family-based treatment program for youth with externalizing behavior problems, often involved in juvenile justice and child welfare systems. FFT is an evidence-based program and has been implemented across many states, including the state of Virginia. Objective. The present study performed a program evaluation and observational study of the implementation and sustainment of FFT in Virginia, during the first five years of implementation. Method. Participants included all youth who participated in FFT in Virginia between October 2017 and June 2022. Secondary data analysis was conducted using data entered by therapists and supervisors into the FFT …

Sphingosine Kinase 2 Depletion Dysregulates Hepatic Redox Metabolism And Enhances Inflammation In Early Metabolic Dysfunction-Associated Steatohepatitis (Mash), Kaitlyn Georgene Jackson

Theses and Dissertations

Metabolic dysfunction-associated steatotic liver disease (MASLD) currently affects one in three people worldwide; its prevalence is growing alongside other cardiometabolic disorders. Aberrations to redox and sphingolipid metabolism contribute to MASLD pathologic progression. Sphingosine-1-phosphate (S1P) is an active lipid, meaning that S1P participates in biochemical processes within the cell. S1P is generated by two distinct isoenzymes, sphingosine kinase (SphK)1 and SphK2. The localization of the SphK enzyme dictates S1P function. While cytosolic SphK1-generated S1P is well-characterized, nuclear and mitochondrial SphK2-generated S1P is less known. Moreover, SphK2 depletion effects on cellular redox processes and inflammation are not well-defined.

This study defines the …

Benchmarking And Enhancing Generalization In Multilingual Speech Emotion Recognition, Mohamed Osman Ismael

Theses and Dissertations

Speech Emotion Recognition (SER) is pivotal in advancing human-computer interaction by enabling machines to understand and respond to human emotions. Despite significant progress with self-supervised learning models, SER systems often struggle with generalization across diverse languages and unseen data distributions, limiting their real-world applicability. This thesis addresses these challenges by first introducing a large-scale benchmark to evaluate the robustness and adaptability of state-of-the-art SER models in both in-domain and out-of-domain settings. The benchmark includes a diverse set of multilingual datasets, emphasizing cross-lingual and out-of-domain evaluations to assess model generalization. Surprisingly, we find that the Whisper model, originally designed for automatic …

Trait Mindfulness And Political Polarization: Investigating Neural Responses And Emotional Orientations, Elif Z. Celik

Theses and Dissertations

The rapid escalation of political polarization has led to increased social distancing, aggressive partisan behavior, and discriminatory attitudes among Democrats and Republicans. Prior research has indicated that mindfulness is associated with increased compassion, reduced prejudice, and diminished aggression toward out-group members. This thesis investigates the relationship between trait mindfulness and political polarization by examining neural responses and emotional orientations in individuals with varying levels of mindfulness. This research measured brain activity using functional near-infrared spectroscopy (fNIRS) while participants viewed emotionally charged political videos and neutral content. The primary hypothesis suggested that individuals with high trait mindfulness would exhibit left-lateralized prefrontal …

Transforming Accounting: Robotic Process Automation In The Accounting Environment, Leah Hall

Theses and Dissertations

Over the years, I have worked with many companies that run legacy accounting and operation systems that do not integrate. With the introduction of RPA, it provides these companies with the ability to integrate without the need for customization. This dissertation is my personal pursuit of understanding the risks associated with implementing RPA and identifying specific areas where organizations may face challenges. I accomplish this objective through three papers: a literature review, a survey, and an experiment. The literature review synthesizes RPA literature, organizing it by implementation state. The survey paper provides an analysis of how internal auditors rate particular …

The Role Of Hdac6 In Periodontal Inflammation, Hannah S. Lohner

Theses and Dissertations

Periodontal disease is a polymicrobial infection-induced chronic inflammatory disease and results in irreversible tissue damage and bone loss. While bacteria play a large role in the initiation of this disease, excessive and prolonged inflammatory immune responses are fundamental for its progression, making host directed therapy (HDT) a possible and potentially valuable treatment. Histone Deacetylase 6 (HDAC6) is an enzyme that removes acetyl groups from both histone and non-histone proteins, giving it a potential role in regulating inflammation initiated by pathogenic oral bacteria. Previous studies indicated that HDACs act as a bivalent regulator in inflammatory responses; however, the role that HDAC6 …

“You Are Not Obligated To Complete The Work, But Neither Are You Free To Desist From It.” Richmond Jews In Social Activism Post Civil Rights, Tracy S. Herman

Theses and Dissertations

For centuries, the Jewish people have faced expulsions, pogroms, massacres, and Propaganda. that runs so deep it would be like staring into an abyss. This oppression has motivated Jewish activists worldwide to fight back not only on behalf of the Jewish community but for many areas of perceived need. Jewish involvement in social activism in the U.S. has been particularly recognized by scholars of the labor and Civil Rights movements. This thesis is based on eighteen oral history interviews focused on social activism in Richmond, Virginia since the Civil Rights era. The author conducted these interviews in 2021, 2023, and …

Plk1 Overexpression Drives Tumorigenesis In A Prostate Cancer Mouse Model, Emile Kachouh

Theses and Dissertations

Prostate cancer is the leading cause of cancer-related deaths among men worldwide, and the development of resistance to existing treatments necessitates the exploration of new therapeutic strategies, including combination therapies. This study investigates the role of Polo-like kinase 1 (PLK1), located on chromosome 16p12.2, as an oncogene in prostate cancer. We generated a transgenic mouse model with prostate-specific overexpression of PLK1 to closely mimic human prostate cancer progression. Quantitative PCR (qPCR) analysis was employed to characterize the molecular profile of PLK1, revealing its implication in multiple pathways. To further elucidate the functional consequences of PLK1 overexpression, we confirmed phenotypic progression …

The Effect Of Local Anesthesia When Used In Dental Restorative Cases Under General Anesthesia On Control Of Postoperative Comfort, Elizabeth S. Kleefisch Dds

Theses and Dissertations

Purpose:

To determine the effect of local anesthesia on postoperative comfort in patients undergoing dental care under general anesthesia.

Methods:

This study was modeled as a double-blinded randomized control trial. Patients included healthy children under the age of 6 years scheduled for restorative dental treatment under general anesthesia (GA). Patient behavior was evaluated preoperatively and postoperatively using the Faces, Legs, Activity, Cry and Consolability (FLACC) or other pain score and postoperatively using the Parent’s Postoperative Pain Measure (PPPM). Intraoperatively, participants followed a standardized general anesthesia protocol and were given either local anesthetic (LA) infiltration using 2% Lidocaine 1:100,000 Epinephrine by …

Developing And Testing A Model Of Discrimination, Internalized Oppression, Mental Health, And Suicidality In Disabled Transgender And Gender Non-Binary (Tgnb) Individuals, Stephanie L. Cull

Theses and Dissertations

Transgender and gender nonbinary (TGNB) individuals experience high rates of discrimination and microaggressions that can lead to internalized cisgenderism and adverse mental health outcomes such as depression, anxiety, and suicidality. Individuals with disabilities similarly experience high rates of discrimination and microaggressions that can lead to internalized ableism and increased adverse mental health outcomes. Although both of these populations have been researched separately, very little extant research has explored the intersections of disabled and TGNB identities. The purpose of this study was to explore a hypothesized pathway leading from microaggressions through internalized oppression and mental health to suicidal ideation within a …

An Examination Of Hiring Practices And Employee Retention Today Compared With Pre-Pandemic Characteristics In Orthodontics, Logan Passey

Theses and Dissertations

Purpose: Evaluate current hiring practices and employee retention characteristics in orthodontic private practices.

Methods: Orthodontists (n=1000) were surveyed regarding their hiring methods and outcomes. Responses were summarized with descriptive statistics. Chi-square tests were used to compare hiring practices and perceptions. Nonparametric Kruskal-Wallis tests were utilized in analysis of retention thresholds.

Results: Survey response rate was 7.2% (72 responses). When comparing thresholds previous to, and after the COVID-19 pandemic, there was an increase in open clinical positions compared with non-clinical and managerial positions (p=.0008). 68% of orthodontists reported a decrease in qualified applications for clinical positions compared with non-clinical and managerial …

Surface Engineering On Functional Materials For Sustainable Environmental Research, Jianping Chen

Theses and Dissertations

My dissertation addresses the urgent need for environmental solutions by developing innovative materials and methods to reduce carbon dioxide (CO₂) emissions. It encompasses two main research initiatives: the creation of metal-organic frameworks (MOFs) using a microdroplet-based spray process, and the enhancement of electrochemical reduction (ECR) of CO₂.

A significant innovation in my work is a novel technique for MOF production, which utilizes atomized microdroplets of MOF precursor solutions. This method significantly reduces processing time and enhances scalability. Specifically, it produces copper 1,4-benzenedicarboxylate (Cu-BDC) MOFs, optimizing operating pressures and flow regimes to discover unique morphologies that could …

A Retrospective Chart Review Of Avulsion Injuries Treated At Virginia Commonwealth University., Ryan Hediger

Theses and Dissertations

A RETROSPECTIVE CHART REVIEW OF AVULSION INJURIES TREATED AT VIRGINIA COMMONWEALTH UNIVERSITY. By: Ryan Hediger, DMD

Objective: Outcomes related to healing following an avulsion injury are multifactorial. However, contemporary literature suggests that tooth survival can be enhanced after such injuries by promptly replanting the tooth and adhering to proper management guidelines. Despite the abundance of resources available, the actions taken immediately after the avulsion injury play a pivotal role in determining the fate of an avulsed tooth. The primary objective of the current investigation is to unveil prognostic factors associated with the survival of avulsed teeth.

Methods: A chart review …

Housing For Transgender And Gender Expansive People In The U.S. South, Aaron M. Kemmerer

Theses and Dissertations

Housing is a prominent issue for transgender and gender expansive (TGE) people around the world. There is a dearth of research about TGE people experiencing homelessness (TGE PEH) in the U.S. South. This dissertation aims to amplify the voices of TGE Southerners around the social concerns of housing and homelessness – this work also disrupts gendered and racialized narratives about housing injustice, exposing the salience of intersectional discrimination and cisgenderism in housing outcomes for TGE people. Using narrative and visual methods, this dissertation re-presents stories and recommendations from in-depth interview data collected from a small qualitative sample of Southern TGE …

A Critical Perspective On Supporting Parents In Facilitating Informal Steam Learning On Children's Early Literacy Development, Suzanne G. Alexandre

Theses and Dissertations

Considering that parents/caregivers and home environment play an influential role in a child’s school readiness and future academic success, this study sought to support parents in using facilitation strategies to engage their child in informal learning at home. In order to examine if access to support for parents of preschoolers influenced parents’ confidence in their ability to facilitate informal learning at home, the project used informal STEAM learning, for context. The study also examines the potential impact of informal STEAM learning on children's school readiness and early literacy skills and the intersections of parent involvement, STEAM, and school readiness through …

Exploring Drivers Of Sex-Based Disparities In Relapsing Multiple Sclerosis, Stephanie K. Buxhoeveden

Theses and Dissertations

Females are three times more susceptible to relapsing multiple sclerosis (MS) and males typically have more severe disease, but the molecular underpinnings of these sex-based disease disparities are unknown and represent a critical knowledge gap.Subject Population: Blood samples from a demographically homogenous group of treatment naïve males and females with relapsing-MS and healthy controls. Research Design: Cross-sectional combinatorial omics pilot study. Instruments: Whole transcriptomic analysis with messenger RNA (mRNA) expression profiling using next generation sequencing (RNA-seq) and micro-RNA (miRNA) expression using NanoString technology. Aim 1) Identify and compare the actively expressed mRNAs in the transcriptome of males and …

Investigating The Regulation Of Epithelial-Mesenchymal Transition Through Fibronectin-Mediated Tgf-Β1 Mechanotransduction Using In Vitro Models Of Triple-Negative Breast Cancer, Michael M. Sofroniou

Theses and Dissertations

TGF-β1 is a potent regulator of epithelial-mesenchymal transtion (EMT), a cellular
transdifferentation process that promotes cellular motility and matrix remodeling, critical to tumorigenesis and metastasis. TGF-β1-induced EMT promotes the assembly of FN, which synergistically binds latent TGF-β1 to aid in its activation. The purpose of of this work is to further probe the effects of autocrine TGF-β1 signaling during EMT progression by utilizing CRISPR-Cas9 deletion of the TGFB1 gene in in vitro models of triple-negative breast cancer. The studies outlined in this work demonstrate that autocrine TGF-β1 maintains a baseline level of mesenchymal marker expression. It also functions to desensitize …

Notes On A Centrifugal Chiller: Listening And Breathing The Boundaries Of Circulatory Architecture, Chrystine Rayburn

Theses and Dissertations

"Notes on a Chiller" unfolds as a series of site responsive and performative exercises that activate, modulate, and translate the immense voice of Virginia Commonwealth University’s Siegel Center water-cooled chiller, a climate control system that regulates the atmosphere of the university’s sports arena. Using individual and collective listening and sound-making practices to harness the building’s noisy system, the piece culminates in a multi-channel, audio-visual installation and performance that explores the multi-sensory exchange and entanglement of listening, breathing, and moving with a building’s circulatory system.