Digital Commons Network^™

Potent And Selective Small Molecule Mcl-1 Inhibitor Demonstrates Anti-Myeloma Activity And Overcomes Chemotherapy Resistance, Omar Sami Faleh Al-Odat

Theses and Dissertations

Despite a record number of clinical studies investigating various anti-myeloma treatments, the 5-year survival rate for multiple myeloma (MM) patients in the US is only 55%, and nearly all patients relapse. Poor patient outcomes demonstrate that myeloma cells are "born to survive” which means they can adapt and evolve following treatment. Thus, new therapeutic approaches to combat survival mechanisms and target treatment resistance are required. Importantly, Mcl-1, anti-apoptotic protein, is required for the development of MM and treatment resistance. This study looks at the possibility of KS18, a selective Mcl-1 inhibitor, to treat MM and overcome resistance. Our investigation demonstrates …

Continuum Mechanics Modeling Of High Strain Rate Impact Of Thermoplastic Polymer Particles, Jeeva Muthulingam

Theses and Dissertations

The study of particle impact at high strain rates is crucial in fields ranging from materials science and engineering to space exploration and environmental science. In the particular case of cold spray, a particle undergoes intense plastic deformation upon impact, causing it to adhere to the target substrate. While metallic particles impacting on metallic substrates have been extensively studied, understanding the mechanical characteristics of polymeric particles on polymer and metal substrates requires further research. This study focuses on single particle impact modeling, analyzing impact parameters such as particle size, velocity, and angle of incidence using continuum mechanics finite element modeling …

Recognizing The Role Of Rhetoric In Secondary Writing Groups, Catherine Schrecengost

Theses and Dissertations

This project seeks to mediate one of the most significant issues with implementing writing groups in the secondary classroom: students do not know how to meaningfully engage in discussions about their writing. Students lack the necessary skills as well as understanding of the rhetorical nature of language to effectively request and provide feedback on pieces of writing. The application of theories of dialogue and collaboration to the research about writing groups suggest that the quality of student writing depends on the quality of their discussions about writing. Thus, my action research study investigates the types of language used between students …

Understanding The Mechanical And Electrochemical Impacts Of Binder Systems On Silicon Anodes In Lithium-Ion Batteries, Fei Sun

Theses and Dissertations

Silicon has emerged as a promising alternative to traditional graphite as an anode material in battery technology, primarily due to its high theoretical capacity and abundance. However, its application is hindered by significant challenges, including severe volume expansion in the active material (~275%) during cycling, which can lead to a series of electrode failure issues. Polymer binder plays an essential role in addressing these challenges as it accommodates silicon's volume expansion and the rearrangement of particles. This work conducted an analysis of how different binders influence mechanical and electrochemical properties of silicon electrodes. Our findings are supported by a series …

Integration Of Machine Learning In Structural Health Monitoring For Damage Identification And Response Prediction In Bridges, Naga Lakshmi Chittitalli Ravuri

Theses and Dissertations

Machine learning-based structural health monitoring (ML-SHM) plays a pivotal role in enhancing structural resilience. By recognizing potential hazards, implementing resistance measures, facilitating swift recovery, and continuously monitoring structural health, ML-SHM ensures proactive maintenance and minimizes recovery delays post-events. Leveraging machine learning algorithms and sensor data, ML-SHM enables early detection of anomalies, prediction of failures, and adaptive responses, enhancing the structure's ability to withstand and recover from adverse conditions. This integrated approach not only improves the structure's performance and adaptability but also contributes to overall safety and longevity. This thesis presents a comprehensive exploration of structural health monitoring (SHM) techniques for …

Spatial Patterns In Anthropomorphic Fremont Rock Imagery Of Central Utah, Alyssa Pitts Merrill

Theses and Dissertations

Rock imagery from the late Fremont period (1000-1300 AD) has captivated the interest of both professional and avocational researchers for the past century. In this thesis, I apply a highly systematized method of cataloguing and analysis to 482 anthropomorphs from Clear Creek Canyon (CCC) and Grand Staircase Escalante National Monument (GSENM). The primary theoretical assumption in this thesis is that the shapes used in anthropomorphic imagery convey ideas about how the Fremont saw people. I therefore recorded the head and body morphology and presence of arms, legs, and genitalia of each anthropomorph. By observing the data spatially, I discovered both …

"Vampire Plastics": An Investigation Of Poly(Olefin Sulfone) Depolymerization And Its Dust Mitigation Abilities, Alexandra Kathryn Kanani Gallion Stapley

Theses and Dissertations

The ubiquity of particulate contamination requires dust mitigation techniques to provide low-scatter surfaces and edges on sensitive optical devices in space. Poly(olefin sulfone)s have been shown to photodegrade with the assistance of a photobase generator when exposed to UV light (254 nm) and heat (120 °C). These polymers may be useful for minimizing dust on optical surfaces for space applications. However, their behavior in vacuum has not been fully characterized. We synthesized poly(2-methyl-1-pentene sulfone) (PMPS) and poly(1-hexene sulfone) (PHS) with and without a photobase generator. We studied the photodegradation (172 nm or 254 nm) of thin films in vacuum. Spectroscopic …

Tool Life Characterization In Refill Friction Stir Spot Welding, Ruth Guadalupe Belnap

Theses and Dissertations

As light-weighting becomes a priority for the automotive industry, refill friction stir spot welding emerges with enormous potential to supplement or replace conventional spot joining processes. This thesis addresses the limitations of current tooling options by examining materials beyond steel for use in RFSSW. Contained herein is an analysis of weld quality as a function of tool material, a production evaluation of RFSSW using various tool materials, and an assessment of long-term performance of a tungsten carbide tool. Over the course of this research, tungsten carbide emerged as a viable candidate for long-lasting RFSSW tooling.

The Osteological Neutral Pose Of The Neck Of An Apatosaurine Sauropod Based On Virtual And Physical Models, Colin Don Boisvert

Theses and Dissertations

An array of sauropod taxa coexisted in Late Jurassic North America. How so many giant genera coexisted without competing for food is puzzling considering their potential metabolic requirements. One aspect of this question is neck posture, which has been much contested, both in terms of the intrinsic curvature of the neck and the resultant elevation of the head. Neck curvature is characterized by the Osteological Neutral Pose (ONP), wherein the intervertebral joints are in an undeflected state. This pose is crucial to understanding neck posture. The articulated series of presacral vertebrae 2-19 of an exceptionally well-preserved apatosaurine, BYU 18531, are …

The Sound Of Silence: Listening For God In Cormac Mccarthy's The Road, Brittany Higgins Maloy

Theses and Dissertations

In the decimated and silent post-apocalyptic setting of Cormac McCarthy's The Road, the main characters spend a significant amount of time listening to silence, listening for signs of danger, but also listening for the voice of God. Many have discussed the hopeless nihilism juxtaposed with the heavy use of Christian iconography in the novel classifying it within one of these dichotomies or somewhere on the spectrum in between. This paper argues that the hopelessness and stark silence is required to reveal hope and the opportunity to hear God's voice. To demonstrate my argument, I define the characteristics of silence, stillness, …

Implementing 1.5 Millimeter Internal Diameter Columns And A Portable Capillary Column Instrument Into Monoclonal Antibody Analytical Workflows, Benjamin Libert

Theses and Dissertations

Using 1.5 mm inner diameter (i.d.) columns to bridge the gap between routinely used 2.1 mm i.d. columns and capillary bore columns allows for a sequential but significant increase in performance without the need for specialized equipment associated with very low dispersion liquid chromatography (LC) systems. These 1.5 mm i.d. columns balance an increase in sensitivity compared to 2.1 mm i.d. columns (theoretically doubling the time-domain peak area in mass sensitive detectors for the same mass load), while mitigating the efficiency losses due to extra-column dispersion effects that are commonly observed with 1.0 mm i.d. columns. Here, the use of …

Reinforcement Learning For Robotic Tasks: Analyzing And Understanding The Learning Process Using Explainable Artificial Intelligence Methods, Brian J. Campana

Theses and Dissertations

As deep reinforcement learning (RL) models gain traction across more industries, there is a growing need for reliable agent-explanation techniques to understand these models. Researchers have developed explainable artificial intelligence (XAI) methods to help understand these 'black boxes'. While these models have been tested on many supervised learning tasks, there is a lack of examination of how these well these methods can explain hard reinforcement learning problems like robotic control. The sequential nature of learning RL policies and testing episodes create fundamentally different policies over time compared to more traditional supervised learning models. In this thesis, two important questions are …

Utilizing Funds Of Knowledge In An Early Childhood Classroom To Enhance And Create Read-Aloud Experiences, Grace Katharine O'Malley

Theses and Dissertations

The purpose of this study is to investigate the read-aloud experiences in an early childhood classroom that embed students Funds of Knowledge (FoK). The specific aim is the explore what happens when I utilize my students' funds of knowledge when planning and implementing read-aloud experiences. what happens when I utilize my students' funds of knowledge when planning and implementing read-aloud experiences. The students demonstrated making connections to peers in response to text, engaging with text that highlights funds of knowledge and conversing about others culture through play. The implications for utilizing Funds of Knowledge in an early childhood classroom is …

Investigation Of Process-Structure-Property Relationships In Additively Manufactured Chopped Fiber-Reinforced Polymer Composites, Indu Modala

Theses and Dissertations

Fiber-reinforced polymer (FRP) composites are widely used in various industries because of their high stiffness-to-weight ratio. However, traditional manufacturing processes restrict the application of FRP composites to the production of parts with simple geometries. With the advent of additive manufacturing (AM), it is possible to produce topologically optimized parts with complex geometries using chopped FRPs. Fully leveraging the advantages of AM in the fabrication of chopped FRP parts requires a thorough understanding of the effect of the process parameters on the microstructure, and subsequently on the mechanical properties of the manufactured part. This research focuses on studying the process-structure-property (P-S-P) …

Communication Between Young Adults And Their Siblings With Autism, Shane Morgan Petersen

Theses and Dissertations

As adolescents transition into young adults, many changes take place within family relationships as young adults move away from home. Young adults may be living away from parents and siblings for the first time and will establish communication patterns that can affect the rest of their life (citation). Relationships largely rely on communication in which young adults and their siblings with autism may experience changes in communication patterns as they move away from home. This study examined six young adults who all have a sibling with autism with whom they are no longer living. An examination of how close these …

The Voice As Identity: How Opera Has Influenced Dubbing In Italy And The United States, Brynn Allison Staker

Theses and Dissertations

An enduring Italian tradition of celebrating the voice and the Italian language as seen by the Italian perception and interest in opera has created an environment of celebration for Italian dubbers. The long-established history of opera in Italy, as well as the modern reception of Italian opera, have effectively placed the voice at the forefront of the Italian entertainment industry. This can be seen through an examination of the careers of Italian dubbers and the success that they saw in their industry. The United States did not have a longstanding operatic tradition, and when opera was introduced it was under …

Unlocking Understanding: Enhancing Scientific Literacy Through Interdisciplinary Reading Strategies In High School Science Classes, Nancy C. Hollenweger

Theses and Dissertations

This study investigated the intersection of literacy instruction and high school science teaching in response to low proficiency levels in these areas and interest in pursuing STEM careers among U.S. high school students. Participants reported using close reading practices combined with inquiry-based science instruction to enhance students’ science literacy and reading proficiency. Data were from document analysis, one-on-one interviews, and focus group discussions. Five significant themes showed teachers' journeys from recognizing a problem to implementing new instructional strategies while pursuing knowledge about how to continue growing their craft. The five themes included teacher awareness of students’ literacy struggles, the apprehension …

Procedural Pre-Training For Visual Recognition, Connor S. Anderson

Theses and Dissertations

Deep learning models can perform many tasks very capably, provided they are trained correctly. Usually, this requires a large amount of data. Pre-training refers to a process of creating a strong initial model by first training it on a large-scale dataset. Such a model can then be adapted to many different tasks, while only requiring a comparatively small amount of task-specific training data. Pre-training is the standard approach in most computer vision scenarios, but it's not without drawbacks. Aside from the cost and effort involved in collecting large pre-training datasets, such data may also contain unwanted biases, violations of privacy, …

Chromosome-Scale Assemblies And A Pangenome Reveal Ltr Repeat Dynamics As A Major Driver Of Genome Evolution In Chenopodium, Kate E. Jaggi

Theses and Dissertations

The genus Chenopodium, which comprises around 150 species globally, is characterized by its wide geographic distribution and ecological adaptability, particularly in temperate regions. Some species, such as Chenopodium quinoa and Chenopodium pallidicaule, have served as domesticated staple crops in the Andean region of South America for centuries, valued for their robust nutritional profile and adaptability to adverse environmental conditions. In contrast, wild Chenopodium species exhibit broad geographic distributions and diverse niche adaptations, functioning as reservoirs for beneficial traits, including disease resistance and climate hardiness, essential for enhancing domesticated crops through introgression and breeding efforts. However, taxonomic classification within the genus …

Characterizing The Potential For Failure In Environment Testing Due To Bolted-Joint Friction Nonlinearity And Bilinearity, Brennen Clark

Theses and Dissertations

Nonlinear behavior in systems complicates the analysis and design of many systems in engineering. In vibration engineering, typical methods such as modal analysis fail or require significant adjustment in the presence of nonlinearity. Understanding and modeling nonlinear behavior is becoming more important in many modern engineering applications. One area that is relatively unexplored is how nonlinearity affects environment testing. This can cover a wide variety of subtopics, but this thesis focuses on failures that can occur in a system which are not predicted by corresponding linearized systems. To further limit the scope of this work, and to provide a context …

Parent Involvement Programs And Latinx Families: An Evaluation Of The Parents + Schools = Successful Children Program, Katherine Woods Hancey

Theses and Dissertations

Parent's active involvement in their children's educational experience has been shown to have a positive impact on student outcomes, including academic achievement, attitude toward school, and improved skill-development. There is limited research, however, that explores how best to help parents become more involved in their children's schooling, especially across cultural groups. Currently, there are more than 14.4 million Latinx students in public elementary and secondary schools. Due to the recent increase in Latinx students within the U.S., there is a need to better understand and support Latinx parent involvement in schools. This study evaluated the effectiveness of the Parents + …

Evaluating Computational Predictions Of Magnetic Resonance Acoustic Radiation Force Imaging For Breast Cancer Focused Ultrasound Surgery, Chloe K. Nelson

Theses and Dissertations

Purpose: In magnetic resonance-guided focused ultrasound (MRgFUS) therapies performed in highly heterogeneous tissues such as the breast, the focal location must be located and characterized to guide successful treatments of tumors. Treatment time can be minimized by a priori prediction of the focal location through computational models. The purpose of this work is to evaluate numerical simulations of focused ultrasound (FUS) on their predictions of the focal location. Those simulations are compared to clinical magnetic resonance acoustic radiation force imaging (MR-ARFI) data collected during in vivo treatment of breast tumors. Methods: The focal location was evaluated prior to MRgFUS treatment …

Zeros Of Convex Combinations Of Elementary Families Of Harmonic Functions, Rebekah Ottinger

Theses and Dissertations

Brilleslyper et al. analyzed a one-parameter family of harmonic trinomials, and Brooks and Lee analyzed a one-parameter family of harmonic functions with poles. Each family was explored to find the relationship between the size of the parameter and the number of zeros of the harmonic function. In this thesis, we examine convex combinations of members of these families. We determine conditions under which the critical curves separating the sense-preserving and sense-reversing regions are circular. We show that the number of zeros of a convex combination can be greater than the maximum number of zeros of either part.

A Grounded Theory Analysis Of Honesty And Deception In Intimate Relationships, Lyndsey Kunzler Gerring

Theses and Dissertations

Although honesty is valued in intimate relationships, there has not been significant research on the range and different types of honesty and deception and their impacts on couples. The purpose of this study was to explore and define the role honesty plays in intimate relationships by examining the spectrum of honest and deceptive behaviors as described by participants. The study utilized qualitative methods to examine how romantic partners describe various types of honesty and deception in their relationships and the influence these have. The data was taken from part of a larger project on healthy and unhealthy relationships where semi-structured …

Ocean Rain Detection And Wind Retrieval Through Deep Learning Architectures On Advanced Scatterometer Data, Matthew Yoshinori Otani Mckinney

Theses and Dissertations

The Advanced Scatterometer (ASCAT) is a satellite-based remote sensing instrument designed for measuring wind speed and direction over the Earth's oceans. This thesis aims to expand and improve the capabilities of ASCAT by adding rain detection and advancing wind retrieval. Additionally, this expansion to ASCAT serves as evidence of Artificial Intelligence (AI) techniques learning both novel and traditional methods in remote sensing. I apply semantic segmentation to ASCAT measurements to detect rain over the oceans, enhancing capabilities to monitor global precipitation. I use two common neural network architectures and train them on measurements from the Tropical Rainfall Measuring Mission (TRMM) …

Hardware Acceleration Of Numerical Methods For Solving Ordinary Differential Equations, Soham Bhattacharya

Theses and Dissertations

Along with the advancement in technology, the role of hardware accelerators is increasing consistently, delivering advancements in scientific simulations and data analysis in scientific computing, signal processing tasks in communication systems, matrix operations, and neural network computations in artificial intelligence and machine learning models. On the other hand, several high-speed computer applications in this era of high-performance computing often depend on ordinary differential equations (ODEs); however, their nonlinear nature can present a challenge to obtaining analytic solutions. Consequently, numerical approaches prove effective in delivering only approximate solutions to these equations. This research discusses the implementation of a customized hardware accelerator …

Measurements In Kautilya’S Arthasastra, In The Domains Of Public Finance And Governance, Saraswathi Murali M

Theses and Dissertations

Ancient Sanskrit literature has rich discussion of measurements by different authorities. Examples from the Vedic Age and the period of Itihāsas can be found in Ṛgveda (c. 1500 BCE), Rāmāyaṇa, and Mahābhārata. A subsequent, and more elaborate, exercise of codification of measurements, relevant to finance and administration, is observed in Arthaśāstra, written by Kauṭilya, also known as Cāṇakya and Viṣṇugupta (c. 350-275 BCE).

The author, a scholar from Takṣaśilā, was the advisor during Cāndragupta Maurya’s reign (c. 321-297 BCE). After millennia of hibernation, Kauṭilya’s Arthaśāstra resurfaced, in the beginning of the twentieth century. Ever since, Arthaśāstra has been a subject …

Cytotoxicity, Antibacterial And Anti-Inflammatory Properties Of A Synthesized Curcumin Analog And One Of Its Novel Derivatives, Marian Amir

Theses and Dissertations

This research aims to describe the synthesis, characterization, and the biological response via investigating the cytotoxic activity, hypoxic microenvironment response, antibacterial, and anti-inflammatory properties of the novel curcumin analog H-4073 and its succinate derivative (H-4073 SuD) in the context of hepatocellular carcinoma (HCC). The study also aimed to compare the effects of H-4073 and H-4073 SuD to assess their relative efficacy and potential as therapeutic agents. First, the cytotoxic effects of H-4073 and H-4073 SuD were evaluated on HEPG2 cell lines under normal conditions. Results revealed that H-4073 exhibited a significantly better cytotoxic effect than H-4073 SuD in normoxia. However, …

What Follows The Fall? Investigating The Shifting Landscape Of Political Violence In The Wake Of Regime Breakdown, Mariam Ayoub

Theses and Dissertations

While it is commonly argued the prior regime type influences regime breakdown outcomes during contested transitions of power, the observed disparity between two countries with identical prior regime types and distinct post-breakdown results poses a significant challenge to the existing theories. This thesis navigates into the complexities inherent in the post-breakdown sphere by examining how different modes of regime breakdowns can impact the level and duration of state violence instigated by the incoming regime after the breakdown. Developing a theoretical model that compares and contrasts the political environments created after military coups and popular uprisings, this thesis argues that regimes …

Gender Inequality Is Not A "Women Only" Issue: A Case Study Of Egyptian Private News Media, Amira Ahmed

Theses and Dissertations

Discrimination in the workplace among different genders is a significant issue in the news media sector globally. This study aims to determine and measure gender inequality in the Egyptian private news media sector through different indicators, including job payments, workload, promotions, media roles, work safety, and work flexibility, especially post-COVID. A mixed approach was used by conducting sixteen interviews and then a survey of 304 private news media sector participants. As inequalities can be a double-faced case, men's and women's perspectives have been considered in the study sample. Through descriptive and statistical analysis, the research findings revealed new insights to …