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On The Use Of Cfd Modeling And Analytic Methods To Describe Pressure Drop In Highly Dense Structured Adsorbents In Gas Separation Processes And Fundamentals Of Adsorption, Ryan Timothy Sanders

Theses and Dissertations

The scope of this work can be divided into two main thrusts on topics found within adsorption. The first, and primary, topic is the use of CFD and analytical modeling to describe the flow of gas through a parallel, structured adsorbent channel which is described in Chapters 1 and 2. Chapter 1 establishes a non-experimental methodology based on using a 3D Navier-Stokes (NS) computational fluid dynamics (CFD) model in lieu of experiments, for developing 1D axial pressure drop correlations for structured adsorbents with parallel channels. Chapter 2 utilizes the methodology established in Chapter 1 in order to develop a new …

Cell Based Sodium Alginate Microcapsules Within Ocular Disease: A Proof Of Concept, Chelsea Marie Zizzi

Theses and Dissertations

Sodium alginate is a natural polymer that has been widely used as a drug delivery system due to its controlled-release qualities and low cellular toxicity. These capsules are effective at transporting therapeutics in various diseased animal models. Retinitis Pigmentosa is an incurable genetic disease affecting the retina, which causes gradual blindness as the disease progresses. In our study, we injected cell-based sodium alginate capsules into the vitreous cavity of C57BL/6 and Pde6b^rd10/J mice to observe the migration of these capsules in both wildtype and diseased mouse models over a course of 2 weeks. Our intention was …

A Click Chemistry Amplified Nanopore Assay For High Performance Testing Of Protein Biomarkers In Diseases, Xiaoqin Wang

Theses and Dissertations

Nanopore detection technology enables nanometer-scale single-molecule detection, yielding valuable insights into analyte molecules' properties such as size, shape, charge, and concentration. Due to its label-free nature, high sensitivity, and real-time capabilities, it finds widespread application in genomics, proteomics, drug discovery, and environmental monitoring. Click chemistry, encompassing the attachment of a probe or substrate to a biomolecule, termed bioconjugation, features the copper-catalyzed azide-alkyne cycloaddition as a quintessential reaction, forming a 5-membered heteroatom ring. This study harnesses this reaction to craft single-strand DNA probes for nanopore testing, leveraging copper's catalytic properties for signal amplification. Host-guest reaction, a noncovalent bond between molecules, specifically …

An Emic Conceptualization Of Veteran, “You're Either One Of Two Things; You're Captain America Or You're Broken”, Steven Wahle

Theses and Dissertations

The Global War on Terror (GWOT) conflicts have been sustained by an all-volunteer force for over 20 years. There have been no drafts, war bond drives, nor rationing. This is a departure from previous prolonged military conflicts in U.S. history. Volunteers with veteran status are often venerated publicly to express gratitude for their voluntary military service. However, the criterion for veteran status is inconsistent.

In the U.S., former military members tend to be regarded on one of two ends of a spectrum as archetypes in attempts to honor such service. On one end is the veteran hero veteran to be …

Neural Mechanisms Of Estrogen And Inflammation In Female Stress Susceptibility, Samantha Jane Bouknight

Theses and Dissertations

Posttraumatic stress disorder (PTSD) and major depressive disorder (MDD) are highly debilitating psychiatric disorders that notably share stress as an etiological factor. Stress is a common occurrence experienced daily by virtually everyone and, while most people are resilient, a substantial portion of the population exhibit risk factors that yield them susceptible to developing stress-related psychiatric disorders. One prominent factor that has long been known to increase this risk is the female biological sex with women presenting at least twice as often with disorders like PTSD and MDD compared to men. Interestingly, this bias exists distinctly during the reproductive years and …

Effects Of A Classroom Cognitive Apprenticeship On Scientific Reasoning, Student Agency, And Biology Self-Efficacy On Students In High School Biology, Anne Morris Byford

Theses and Dissertations

Students entering high school often bring misconceptions about the nature of science and experimentation with them from middle school. Many also bring a belief that they are not a “science kid” and, therefore, cannot be a strong student in Biology. This belief can lead to a lack of self-efficacy and of student agency in the classroom. Exposure to authentic research experiences has been shown to increase in self-efficacy and scientific reasoning. Typical research experiences have been limited to summers, specialized after school programs and, in many cases, honors students. To circumvent the unequitable access to these experiences and to determine …

Dual-Phase Membrane Reactor And Calcium Oxide-Based Sorbents For High-Temperature Carbon Capture, Utilization And Storage, Kangkang Zhang

Theses and Dissertations

Greenhouse gases, especially CO2 emissions, are responsible for global warming and the reduction of greenhouse gases is vitally important for the sustainability of our modern society. Currently, the most mature CO₂ capture, utilization and storage (CCUS) technology relies on flue gas “amine washing”, a costly and energy intense process that can negatively impact on the efficiency of existing power plants and the cost of electricity produced. Therefore, developing more efficient and cost-effective CCUS technologies is highly imperative. With the increasing production of natural gas in recent years, direct natural gas conversion into valuable chemicals also becomes more attractive than …

Investigation Of The Environmental Factors Regulating The Biomass And Toxin Production Of The Benthic Cyanobacterium Microseira Wollei In Lake Wateree, South Carolina, Kara Clyburn

Theses and Dissertations

Impacts from anthropogenic activities and climate change are significantly altering nitrogen (N) cycling processes and biological productivity along the freshwater to marine continuum, and the acceleration rate of excessive N and phosphorus (P) concentrations entering aquatic environments is unprecedented. As a result, nutrient pollution is contributing to the increasing magnitude and duration of cyanobacterial harmful algal blooms (cHABs), oxygen (O2) depletion, loss of biodiversity, and impacts to human and ecosystem health. Lake Wateree, South Carolina (SC) is a freshwater drinking and contact recreational water resource with elevated symptoms of eutrophication, including the increasing prevalence of the N2 fixing benthic cyanobacterium …

Perspectives From Caregivers For Children With Retinoblastoma: Psychosocial Concerns And Genetic Counseling, Kayla Marie Lashinger

Theses and Dissertations

Caregivers play a vital role in the care of children affected with retinoblastoma as most cases are diagnosed before the age of five years old. While previous studies have explored the psychosocial needs of caregivers of children with pediatric cancer, these have not specifically focused on retinoblastoma in the United States (US). Prior research identified the profound emotional burden in terms of depression, anxiety, guilt, isolation, and loneliness experienced by caregivers. Given previous findings and the National Cancer Institute’s recommendation for genetic counseling and testing for all individuals affected with retinoblastoma, this study aimed to assess psychosocial concerns in relation …

Preimplantation Genetic Testing For Sickle Cell Disease; Exploring The Effect Health Disparities Have On Parental Awareness And Interest, Justine Frances Manigault

Theses and Dissertations

Sickle cell disease (SCD) is a group of disorders of the hemoglobin resulting in episodes of chronic pain, pulmonary hypertension, progressive multiorgan damage, risk for stroke, and increased mortality. It is caused by biallelic pathogenic variants in the HBB gene and 1 in 12 African Americans, 1 in 100 Hispanic individuals, and 1 in 30-50 Mediterranean people are reported to be carriers of the disease and have sickle cell trait (SCT). SCD is typically diagnosed through newborn screening; however, when prospective parents are aware of their carrier status, they can conceive via in vitro fertilization (IVF) and have genetic testing …

Understanding The Role Of Host Derived Interleukin 1 Alpha In Breast Cancer Progression, Manikanda Raja Keerthi Raja

Theses and Dissertations

In breast cancer research, Interleukin-1 alpha (IL1α) remains a lesser-explored frontier, while its counterpart, Interleukin-1 beta, has garnered extensive scrutiny and understanding. To address this knowledge gap, our investigation leveraged the MMTVdriven HER2+ orthotopic model in Wildtype (WT) and IL1α-/- mice. Our approach demonstrated tumor regression in IL1α-/- mice at the 2-week timepoint, while WT tumors grew exponentially. At 2 weeks, IL1α-/- mice exhibited an immune "hot" microenvironment with increased CD45+ immune cells, particularly CD11b+ myeloid, and CD8+ T cells. CD8+ cells in IL1α-/- mice showed enhanced anti-tumor cytokine production and proliferative capability, with …

Becoming Musical: Towards A Typology Of Non-Musical Sounds In Recorded Popular Music, Jacob David Mccooey

Theses and Dissertations

There are many instances in popular music in which traditionally non-musical sounds are used musically. There is currently no research on the types and functions of non-musical sounds used musically (NMSUMs). I have collected and organized a collection of example tracks that contain these NMSUMs and analyzed their functions to determine a typology of these sounds. The analysis of the NMSUMs focused on intertextuality, intratextuality, form, texture, and how the sounds relate to traditional, musical sampling. Throughout the course of the analysis, several trends were distinguished amongst the many tracks gathered, and these trends form the basis of the typology.

Electronic Structure Investigation Of Photoswitch-Embedded Organic Frameworks And External Electric Field Effects On Carbon Dioxide, Austin Hill

Theses and Dissertations

Metal- and Covalent-Organic Frameworks (MOFs and COFs, respectively) are chemically versatile systems that have diverse applications, ranging from drug delivery to energy storage. This versatility is due to the highly tunable nature of organic frameworks, which utilize metal clusters, chemically diverse metals, and organic ligands. Researchers have recently demonstrated how MOFs and COFs can be remotely tuned through the use of photochromic organic linkers and light (Martin, et al., 2022). The implications of these findings are significant and have numerous applications, primarily in optical switching and energy storage. However, the photochromic mechanism within the organic framework must be investigated, which …

Impact Of Equitable Grading Practices On Student Outcomes And Biology Self-Efficacy In A Ninth Grade Biology Class, Laura Boyle

Theses and Dissertations

This action research study, set in a midwestern high school in the United States, was designed to investigate the impact of implementing equitable grading practices in a first semester freshman biology course. Many grading practices commonly used in classrooms in the United States are subjective, can be used to maintain compliance in the classroom, and do not accurately report what students know and can do. Ideas from Critical Race Theory and Bandura’s Self-Efficacy Theory guided this study. Qualitative and quantitative data were collected through pre and post self-efficacy surveys, grading surveys, and semi-structured student interviews, along with quantitative grade data …

Global Well-Posedness Of Nonlocal Differential Equations Arising From Traffic Flow, Thomas Joseph Hamori

Theses and Dissertations

Macroscopic traffic flow models describe the evolution of a function ρ(t, x), which represents the traffic density at time t and location x according to a differential equation (typically a conservation law). Numerous models have been introduced over the years which capture the phenomenon of shock formation in which the solution develops a discontinuity. This presents difficulties from the standpoint of mathematical analysis, necessitating the consideration of weak solutions. At the same time, this undesirable mathematical behavior corresponds to unsafe driving conditions on real roadways, in which the heaviness of traffic may vary abruptly and dramatically. This thesis introduces and …

Assessing Multi-Annual Phytoplankton Community Compositions And Biomass Across Tidal Creek And Open Water Estuarine Habitats In South Carolina, Shannon Elizabeth Powers

Theses and Dissertations

The urbanization of coastal environments in recent decades has caused an accelerating increase in nutrient-rich runoff from the landscape. The presence of these excess nutrients in the aquatic environment can result in degradation of water quality and harmful algal blooms. In South Carolina (SC), coastal development continues to threaten the resiliency of salt marsh estuaries, especially in combination with other stressors like climate change and sea level rise. Estuaries are important nurseries and habitats for fisheries and ecotourism. The South Carolina Estuarine and Coastal Assessment Program (SCECAP) is an ongoing monitoring program that assesses the habitat condition along the coast …

Continuous Improvement Of Schools: Providing Opportunities For 3rd Grade Growth Through Pdsa Cycles In Professional Learning Communities, Jason Koepke

Theses and Dissertations

When observing and consistently hearing about the obstacles that our current public educational system is facing, many are left wondering what can be done to produce genuine, significant, and continuous improvement. Upon deeper analysis of educational systems, one can see that there are many areas in need of systems improvement. SOAR School is a Pre-K-5 school that has experienced underperforming student achievement outcomes. This study was a collaborative approach to the current educational system. SOAR School used the data from universal screeners and progress monitoring assessments to drive the professional learning communities within the school. SOAR School had never experienced …

The Utility Of Referrals From A State Early Intervention System To A Pediatric Genetics Clinic To Increase Access To Genetic Services, Mikayla Jennings

Theses and Dissertations

Infants or toddlers enrolled in state early intervention programs have developmental delays or are diagnosed with conditions that may result in developmental delays. These infants receive a wide range of services from early intervention. In the state of South Carolina, children in the early intervention program are offered genetic evaluations at no cost to the family. Exploring the relationship between state early intervention systems and genetic clinics and the impact on this particular patient population can provide support for new and continued use of this service delivery model.

The purpose of this study was to evaluate the service delivery model …

On Parallelization Of Graph Algorithms, Performance Modelling And Autonomous 3d Printable Object Synthesis, Shams-Ul-Haq Syed

Theses and Dissertations

The degree of hardware level parallelism offered by today’s GPU architecture makes it ideal for problem domains with massive inherent parallelism potential, fields such as computer vision, image processing, graph theory and graph computations. We have identified three problem areas for purpose of this research dissertation, under the umbrella of performance improvement by harnessing the power of GPUs for novel applications. The first area is concerned with k-vertex connectivity in graph theory, the second area deals performance evaluation using extended roofline models for GPU parallel applications and finally the third problem area is related to synthesis 3D printable objects from …

Experimental And Computational Understanding Of Solid Oxide Iron Air Battery Performance, Chaitali Morey

Theses and Dissertations

Long-duration energy storage (LDES) (10+ hours) is considered a key technical solution for a widespread penetration of renewable energy into the utility market. However, the currently available storage technologies are limited to less than 10 hours for cost reasons. The benchmark Li-ion battery technology would be economically prohibitive if the storage time goes beyond 4 hours. Therefore, developing new low-cost LDES-compatible battery technologies is highly desirable. A solid oxide iron air battery (SOIAB) has been developed which consists of a reversible solid oxide cell (RSOC) and energy storage unit (ESU) of an iron bed. This battery is considered a promising …

Coastal And Inland Flooding - From Advanced Hydrodynamics And Data-Driven Modeling To Multi-Variate Coastal Vulnerability Assessment, Ahad Hasan Tanim

Theses and Dissertations

Flood risks in coastal and inland areas have historically been underestimated and underpredicted, resulting in increased flood damage and loss of human life. Flood risk under climate change and sea level rise will disproportionately impact low-wealth and marginalized communities, as they are often located in areas with less flood protection and have limited resources to adapt to the impacts of flooding. The systematic workflow of the life cycle of FRM is frequently disengaged in the current state of flood hazard assessment with system vulnerability assessment. This research aims to improve the life cycle of FRM by incorporating flood observation, monitoring, …

Field Implementation Of A Stereo Vision System For Rnt And Stress Measurements In Cwr, Brittany Stinson

Theses and Dissertations

The use of Continuous Welded Rail (CWR) provides many advantages to the rail industry compared to the alternatively used jointed-track segments. However, one significant disadvantage is the development of thermal stresses longitudinally in the rail, which is not of concern when expansion joints are used. This is due to CWR’s inability to release thermal expansion in the absence of joints. The Rail Neutral Temperature (RNT) is the temperature at which the rail is in a stress-free state. A desired RNT is calculated based on local climate conditions and CWR installation practices are implemented to set the desired RNT at installation. …

Modulation Of Neurodegenerative Disease Progression By Antioxidant Status, Elena Kelety

Theses and Dissertations

Neurodegenerative diseases, including Amyotrophic lateral sclerosis, Alzheimer's disease, and Parkinson's disease, profoundly impact the brain and nervous system. In 2019, the United States reported the highest global prevalence of neurological disorders. This thesis approaches neurodegenerative diseases by emphasizing the critical role of a well-maintained antioxidant system, its intricate relationship with dietary patterns, and proposes an alternative fate of the antioxidant urate.

Neurodegenerative disease pathogenesis involves a complex interplay of neuroinflammation, mitochondrial dysfunction, misfolded proteins, and oxidative stress. Oxidative stress arises from an imbalance in the antioxidant defense system and the production of reactive oxygen species. Synergistic antioxidant interactions are vital …

Sonic Data: Sonification In James Stephenson’S There Are No Words And David Kirkland Garner’S Red Hot Sun Turning Over, Nathan Lee Tucker

Theses and Dissertations

Sonification, or the transformation of data relations into sound, has inspired composers of orchestral and wind ensemble music over the past several years. Two of the resulting works included there are no words by James Stephenson and red hot sun turning over by David Kirkland Garner. Both works were analyzed, and their histories detailed in this study. Issues in American society and the American South such as gun violence, civil rights, and American Civil War monuments are revealed as inspiration for composers to map empirical processes onto sound. These musical protests against misinformation were shown to illuminate histories and correlations …

The Gendered Patterns Of International Migration Systems: The Role Of Need For Care, Chang-Yi Lin

Theses and Dissertations

The demand for feminized jobs in developed countries—e.g., care, domestic, and entertainment work—has provided women with an opportunity to work abroad independently. However, while numerous studies have discussed gendered opportunities and barriers to women’s migration, few studies have examined these correlates globally. According to traditional gender norms, one such potential barrier is women’s childcare responsibilities at home and, more specifically, the number of children who need to be cared for. Here it is argued that, contrary to men, the higher the number of children who need to be cared for in a given country, the more difficult it would be …

The Effectiveness Of Equivalence-Based Instruction On Time-Telling Skills In Children With Moderate Developmental Disabilities Including Autism Spectrum Disorder And Intellectual Disability, Rongzhi Li

Theses and Dissertations

The purpose of this study was to evaluate the effectiveness of equivalence-based instruction (EBI) on teaching time-telling skills to children with moderate developmental disabilities including autism spectrum disorder (ASD) and intellectual disability. Three children with ASD or intellectual disability participated in the study. The experiment was conducted using a concurrent multiple baseline design across subjects. During the acquisition training, each participant was taught 24 discrimination relations including matching 12 picture analog clock faces and 12 printed digital clocks to their dictated times. After the training, the participants were assessed to see whether their visual-visual responses (transitivity relations) and oral naming …

Molecular Rotors For Quantifying Kinetic Effects Of Stabilizing Non-Covalent Interactions, Binzhou Lin

Theses and Dissertations

This thesis describes the development of molecular machines as analytical instruments to measure the strength of non-covalent interactions and to test hypotheses of reaction mechanisms. The first chapter is a review of molecular rotors. The second chapter presents the development of a molecular rotor that can be controlled using electrostatic interactions. Previous examples have used electrostatic interactions to slow down or inhibit molecular motion. Our system is activated and sped up using electrostatic interactions. The third and fourth chapters describe the application of molecular rotors designed to experimentally measure the strength and stability trends for non-covalent pnictogen and chalcogen interactions. …

Stem Identity In African American Middle School Students: A Phenomenological Study, Amara L. Alexander

Theses and Dissertations

Using a phenomenological approach, this action research study explored the influence of culturally sustaining teaching practices (Ladson-Billings, 2014; Paris 2012, 2021) to impact African American students STEM identity (Collins & Roberson, 2020). Qualitative data were generated through interviews with students, practitioner reflective notes, and classroom observations during the intervention. Analysis and interpretation of the data indicated student- participants had positive experiences during the intervention and the culturally sustaining STEM lessons positively impacted African American middle school students STEM identity. The implications of these findings for STEM curriculum writers, STEM education and STEM educators, particularly those in K-12 education.

Kodály Learning: A Qualitative Case Study Based On The Use Of A Blended Curriculum Using The Principles Of Zoltán Kodály In Beginning Piano Study, Megan Elizabeth Rich

Theses and Dissertations

This paper and its corresponding study were created to explore the effectiveness of the Kodály Method on traditional piano lessons and to hone a curriculum with long-term student musicianship at its core. The curriculum was written for a six-week period and intended for students ages six–eight years old. The curriculum follows the melodic and rhythmic sequences of the Kodály Method and blends these sequences with traditional approaches to beginning piano lessons. The purpose of the study is to share and evaluate this curriculum and its results as they pertain to the four study participants.

The study was conducted over a …

Association Between Autoimmune Diseases And Lymphoma Risk Using The Uk Biobank, Hannah Grace Dice

Theses and Dissertations

Background. Lymphoma is a blood cancer that develops when white blood cells multiply in an abnormal way and collect in the lymph nodes. Autoimmune diseases result when the immune system is overactive, causing it to attack and damage the body’s own tissues. Limited studies have been conducted to investigate the association between autoimmune diseases and lymphoma risk.

Literature review. Based on prior research, six autoimmune diseases (rheumatoid arthritis (RA), lupus, Sjögren’s syndrome, sarcoidosis, Crohn’s disease, and ulcerative colitis (UC)) were examined to better understand their association with lymphoma risk. Prior research has concluded that certain aspects of these autoimmune diseases …