Digital Commons Network^™

Relationship Extraction Using Retrieval Augmented Generation For Biomedical Dataset, Jannat .

Theses and Dissertations

With the increasing number of structured and unstructured data, obtaining reliable information effectively has become crucial. In the biomedical domain, extracting information from the scientific papers is crucial in order to stay up-to-date with accurate information, given the increased pace by which new research studies are published. This work focuses on identifying relationships between entities that are extracted from the abstracts and titles of biomedical research papers. In this work, we developed a Retrieval Augmented Generation (RAG) based system to automatically identify relations between biomedical entities. We evaluate multiple open source Large Language Models (LLMs) and the number of examples …

Laser Ablation-Induced Corrosion Resistance For Molten Salt Equipment Materials Evaluated Utilizing Electrochemical And Spectroscopic Analysis, Peggy Milota

Theses and Dissertations

Advanced reactors and used nuclear fuel separation (i.e. pyroprocessing technology) utilize high temperature salt as a thermal storage medium as well as an ionic solution for electrochemical processes. The use of these aggressive molten chloride and fluoride mediums requires specific materials or additional system alterations to extend the lifetime and structural integrity of equipment due to corrosion. Some materials, in the presence of inherently impure salt, will corrode and form oxide films in a specific formation that decreases corrosion rate by electrochemically and physically preventing elemental movement to the material surface. This is referred to as a passivation layer. However, …

Identity Formation Of A Pre-Service Art Educator: An Arts-Based Approach To Data Visualization As A Means Of Understanding Personal Experience, Kelsey L. Peterson Mays

Theses and Dissertations

This research centers on the emotional experience of the author as a pre-service art educator during her student teaching semester. The research utilized art-based data collection methods and analyzed both written and visual reflections over an eight-week period of teaching art at the elementary school level. The culmination of findings is synthesized in the form of a body of four visual artworks, where each work reflects the data collected over a consecutive period of two weeks. The study investigated the causation and ramifications of certain emotions during a transitional time wherein the author existed in a liminal space between student …

Learning To Deceive And Persuade: Predictive Agents With Language And Personality Diversity In Social Deduction Games, Aaron M. Shah

Theses and Dissertations

This thesis presents a novel multi-agent architecture that combines Joint Em bedding Predictive Architectures (JEPA), Free Energy Principle (FEP)–inspired planning, and language-based social interaction. The system is evaluated in a custom Werewolf-style hidden-role game, where agents must coordinate, persuade, or deceive under partial observability. Each agent encodes its belief state into a latent representation, predicts future trajectories under candidate actions, and selects votes or eliminations through a planner trained to minimize prediction error. To enable communication, agents are equipped with trainable mouthpieces. A lightweight SpeakerBandit selects from discrete templates using REINFORCE on judge-derived rewards, while a logit-bias head steers a …

Characterization Of Outer Surface Protein C Of Borreliella Role In Host Tropism, Kathryn Mf Chambers

Theses and Dissertations

The Lyme disease spirochetes, Borreliella spp., are maintained in nature through a complex enzootic cycle involving Ixodes ticks and a diverse set of reservoir hosts. The outer surface protein C (OspC) of the bacterium is an essential virulence factor required for transmission from ticks and early infection of mammals. Deletion of ospC abolishes infectivity, yet the precise molecular mechanisms underlying OspC function remain incompletely defined. In this dissertation, I examined the contribution of OspC type identity to host specificity. OspC is highly diverse, with over 30 genetically stable types described. While intra-type sequences are conserved (>95% amino acid …

Implementation Of Quantized Artificial Neural Networks With Spintronic Stochastic Computing, Saadi Sabyasachi Mr.

Theses and Dissertations

Artificial intelligence or machine learning is going through a rapid expansion. It also incurs significant costs for power and device footprints. Various approaches are being explored to design energy and hardware efficient machine learning models. Stochastic computing has been proposed for efficient machine learning implementation. It requires a source of random number generation which poses some practical challenges. So spintronic solutions such as magnetic tunnel junction has been used for random number generation. Again, spintronic random number generation to implement high precision circuit is prone to device-to-device variations. Hence we designed quantized artificial neural network with spintronic stochastic computing which …

Genetic Studies At The Intersection Of Alcohol Use And Pain, Walker Rogers

Theses and Dissertations

Alcohol use disorder and pain are complex public health concerns affecting millions of people, and these conditions are often characterized by a bidirectional relationship. People experiencing pain may drink alcohol for its analgesic effects. In turn, excessive consumption of alcohol can lead to conditions that cause pain, leading to an escalating feedback loop of pain and alcohol use. Negating this cycle requires a nuanced understanding of the mechanisms underlying alcohol analgesia, which are presently not fully understood. The Miles and Damaj labs have previously shown that ethanol-induced antinociception is moderately heritable in mice, indicating a genetic component to the trait. …

The Design Of A House, Lars Mattingly

Theses and Dissertations

Photography lends itself to both damaging and facilitating connection, the camera at once a weapon of destruction and a catalyst for change. The Design of a House is a call to love deeply. In the aftermath of body trauma, I use portrait photography to reconnect with myself and others. Through making portraits, I bridge my own gap between fear and intimacy. Primarily working with film-based cameras and hand-sensitized photographic materials, I reintroduce touch through process. The slowness, delicacy, and tactility of these acts offer a safety I am learning to trust. When photographing myself, my mother, and my partner, I …

Opioid Tolerance And Withdrawal In The Mouse Colon, James Fune

Theses and Dissertations

Constipation is a major clinical obstacle associated with opioids, prompting patients to discontinue treatment due to pain, discomfort, and psychosocial stressors. Moreover, chronic users become tolerant to the analgesic effects of opioids, but not to their constipating effects. Upon cessation of long-term treatment, serious diarrhea–among other somatic signs of withdrawal–may ensue. These symptoms become a driving factor for relapse, causing patients to restart opioid treatment. In this study, we aim to understand mechanisms that contribute to opioid tolerance and withdrawal in the colon. Previous findings suggest that constipation occurs partly due to the colon’s lack of tolerance to opioids’ inhibitory …

Exploring Western Clinicians’ Treatment Of Cultural Concepts Of Distress, Lisa Y. Chung

Theses and Dissertations

As the rates of diverse ethnic populations and therefore cultural concepts of distress continue to grow in the United States, it becomes critical to learn and understand how western-trained mental health professionals are selecting treatments and implementing them. However, there is a paucity of research on cultural concepts of distress as a whole and much less on the psychotherapy of cultural concepts of distress in the United States. This exploratory study aimed to explore the treatment plan of mental health clinicians in the United States when encountering the Korean cultural concept of distress, hwabyung. Ninety-eight clinicians were recruited from Arkansas, …

Dickkopf1(Dkk1): A Novel Endogenous Ligand To Prime Nlrp3 Inflammasome Via Tlr4, Theingi Aung

Theses and Dissertations

Dickkopf1(DKK1) is a quintessential Wnt antagonist and immunomodulator in various inflammatory diseases. The underlying molecular mechanisms of DKK1-mediated immunomodulation remain elusive. Here, we identified TLR4 as a new receptor for DKK1 to activate NFκΒ pathway-mediated gene expression and pyroptosis via NLRP3 inflammasome in human and mouse macrophages.

DKK1 employed TLR4 to initiate NFκB signaling cascade via MyD88. MyD88-TAK1-NFκΒ pathway activation by DKK1 increased HIF1α, NFκB, and NLRP3 protein expression levels, leading to pyroptosis. Unlike LPS, DKK1 did not induce IRAK4 phosphorylation, while the interaction between MyD88 and IRAK4 was maintained for downstream signaling activation. DKK1 did not induce IRF3 phosphorylation …

Exploring The Development Of Students' Calling To The Work Of An Hod Practitioner In An Undergraduate Hod Degree Program, Neil Dana Rahbar-Daniels

Theses and Dissertations

This dissertation project consisted of a multiple case qualitative study to explore indications of cross-influences between students’ experiences of learning takeaways as participants in one or more HOD undergraduate degree courses and accompanying experiences (if any) of perceiving and/or living a calling to work as HOD practitioners. This phenomenological inquiry involved four undergraduate students who had completed one or more HOD degree courses at Mid-Atlantic States University (MSU as a pseudonym) during a two-year period. Each participant attended a single interview of about 90 minutes in duration, responded to a short vocational calling survey as a guide for interview questioning, …

Profiles Of First-Year First-Generation Students’ Library Perceptions And Use: An Intersectional, Mixed Methods Study, Megan Hodge

Theses and Dissertations

To effectively support first-generation students, academic libraries must understand their needs. However, limited library research has been conducted into how these students, who often embody multiple structurally disadvantaged identities, perceive and use academic libraries or how their intersecting identities manifest in differing library needs. This study aimed to build understanding of first-year first-generation students’ perceptions and use of academic libraries. To do so, the researcher used an explanatory sequential mixed-methods design. First-year first-generation students at Virginia Commonwealth University were surveyed using Winkler and Sriram’s (2015) Academic Capital Scale and Anwar et al’s (2012) AQAK: Library Anxiety Scale for Undergraduate Students. …

From Trans Health To Vaccines: A Theoretically Driven Model Exploring Factors Related To Susceptibility To Medical Misinformation, Catherine Wall

Theses and Dissertations

Medical misinformation represents a significant threat to both individual and public health. While some consequences of this form of misinformation are relatively benign, there can be serious consequences ranging from a decreased trust in healthcare systems to an increased likelihood of epidemic outbreak and death. One such consequence can be seen in the recent legislative actions taken regarding access to transgender healthcare in the United States. Gender affirming care has been shown to benefit the mental well-being of transgender youth and adults; however, the demonstrably false information that underlies these legislative efforts can and has yielded significant harm. But what …

Beliefs Related To Diagnosing Bpd And Complex Ptsd, Bailey Pascuzzi

Theses and Dissertations

There has been speculation that Borderline personality disorder (BPD) and Complex post-traumatic stress disorder (Complex PTSD) are the same disorder or represent separate disorders on a broader trauma spectrum (Frost et al., 2020; Lewis & Grenyer, 2009). BPD and Complex PTSD share several symptoms but differ in their presentation (Ford & Courtis, 2021). Because the two disorders present so similarly, it could be that clinicians have difficulty differentiating them, leading to misdiagnosis (Miller, 2014). This study examined clinicians’ diagnostic decision-making and stigma toward BPD and Complex PTSD. Participants (N = 426) completed an online survey where they diagnosed a written …

Learning From Non-Stationary Data Streams, Gabriel Jonas Aguiar

Theses and Dissertations

The rapid growth of data from sources such as mobile applications, sensors, and network monitoring has increased the need for machine learning algorithms capable of handling non-stationary data streams. However, learning from such streams presents significant challenges due to their evolving nature and the presence of concept drift. One of the most complex issues is learning from imbalanced data streams, where shifting data distributions, combined with feature space drifts, complicate continuous adaptation. These challenges become even more pronounced in multi-class scenarios, which are common in real-world applications. Detecting concept drift in such contexts is particularly demanding, as it requires tracking …

“Some Vague Utopia”: Searching For Urania, Moira L. Neve

Theses and Dissertations

Despite the global pendulum swing of gender trouble marked by the United States’ President’s declaration that there are only two sexes, activists have been rejecting assimilation (ie. defining equality as gay marriage or queer people in the military) within queer studies long before 2025. In the first half of the 20th century, a journal by the name of Urania (1916-1940), privately published and circulated to their home base in the United Kingdom and beyond, five editors (Esther Roper, Eva Gore-Booth, Jessey Wade, Dorothy Cornish, and Irene Clyde/Thomas Baty), challenged the gender binary and the resulting assumptions of heterosexual marriage. This …

Learning And Identity In Cross Functional Teams: A Communities Of Practice Perspective, Penelope K. Mcfarline

Theses and Dissertations

Cross functional teams (CFTs) are groups of diverse professionals leveraged by organizations to address a variety of complex issues. While CFTs have the potential for rapid problem solving, product or service innovation, and knowledge creation, they sometimes underachieve or fail to meet their goals at great cost to the organization. Prior research points to the barriers that diverse professional identities create to CFT performance and learning. This study aims to explore the relationship between the professional identities of cross functional team members, and what and how they learn. A conceptual framework for the study sought to view a CFT as …

The General Movement Optimality Score-Revised (Gmos-R): An Early Biomarker For Developmental Delays, Shaaron E. Brown

Theses and Dissertations

The General Movement optimality score may provide insight into the relationship of term age General Movements and future neurodevelopmental disabilities and could be an early biomarker. This dissertation aimed to determine the relationship between term age neurologic function, measured by the optimality score of the General Movements, and postural control at term and three months (Chapter 2), and the relationship between neurologic function, at term and three months, and 12 month cognitive and motor outcomes (Chapter 3) and the impact of intervention on neurologic function and postural control at three months and on 12 month cognitive and motor outcomes in …

(Art) Education In The Afterlife Of Massive Resistance: Constructing, Capturing, And Commodifying Racialized Disability In Virginia’S Student Assignment Practices, 1956-1966 And Present Day, Jenna E. Gabriel

Theses and Dissertations

This dissertation explores discursive functions of disability in pupil placement decisions in Massive Resistance Virginia, the relationship between disability and race that was constructed through these moves, and how these relationships surface in the reflections, perceptions, and pedagogy of a practicing art teacher, Nathan, who works at Arts High School (AHS), a Virginia specialty center high school. Under the umbrella of the Discourse Historical Approach, which relies on multiple, interdisciplinary data sources to explore how discourses evolve, I connect a robust archival analysis of historical data collected in the records of Virginia’s Pupil Placement Board (746 boxes, 1956-1966) with present-day …

Exploring Prenatal Cannabis Use Among Young Pregnant Bisexual Individuals: A Mixed Methods Study, Nicole Boss

Theses and Dissertations

The perinatal period is a critical time for health behaviors with outcomes that have short- and long-term effects for both childbearing person and child. Research indicates that young bisexual people are at greater risk of unintended pregnancy, experience psychosocial health disparities, and may be more likely to use cannabis during pregnancy. Few studies have examined this phenomenon. This study is a secondary analysis of mixed methods data from a longitudinal cohort study. Thematic analysis of qualitative data (n=12) revealed the contextual adaptivity of cannabis use, with participants explaining the situations and rationales which motivated their cannabis use changed over time. …

Establishing A Conventional Linac-Based Electron Flash Beam, Justin Defrancisco

Theses and Dissertations

Problems: A rediscovered radiotherapy technique, FLASH, involves increasing the dose rate to >40 Gy/s. For a given dose, FLASH is shown to decrease the normal tissue complication probability without affecting the tumor control probability. More preclinical studies are necessary to confirm and enable these desirable properties on humans. Current preclinical investigations have diverse constraints, requiring FLASH apparatuses with flexible parameters and accurate control. However, there are limited FLASH platforms available, the existing ones are costly. Our institution is not in possession of any such infrastructure. Even if available, dosimetry and beam control in FLASH are extremely lacking. There is …

Social Support, Tobacco Attitudes/Perceptions Of Harm, And Asthma Status As Moderators In The Association Between Tobacco Exposure And Cotinine Levels, Rachel L. Pitts

Theses and Dissertations

Tobacco use and exposure are linked to adverse health outcomes (e.g., respiratory conditions) and increased healthcare utilization (e.g., emergency room visits). This study examined the moderating role of social support, tobacco attitudes/perceptions of harm, and asthma status on associations between tobacco use (e.g., combustible product use) and exposure (e.g., secondhand smoke) and cotinine levels among individuals in Richmond, Virginia. We also explored differences in tobacco-related variables by asthma status and associations among tobacco use, secondhand smoke exposure, cotinine levels, and asthma control. Youth (n = 201) and adults (n = 209) (95.7% Black/African American; 60.6% female; 65.8% non-tobacco users; 21% …

Liner Notes On Black Trans Girlhood: Afrofuturist Affect & Black Popular Music As A Praxis Of Self-Fashioning, Shawn J. Williams

Theses and Dissertations

Liner Notes on Black Trans Girlhood: Afrofuturist Affect & Black Popular Music as a Praxis of Self-Fashioning interprets Black musical performance in identity-making, with a focus on how music and Black trans identity intersect and informs Black trans girlhood. As such, Black trans girls render ourselves legible, i.e. understood without shame or judgment, by constructing our identities through the music by Black women we listen and dance to, or watch and sing. These musical connections affirm the possibilities of Black femme expression. This expression of Black femininity is due to what I call an Afrofuturist affect, by which I refer …

Witnessing Intellectual Humility: How A Peer’S Humble Introduction Affects Feedback Receptivity And Social Perception, Stephanie A. Barrientos

Theses and Dissertations

Might intellectual humility (IH) be contagious? Across two studies, we examined how individuals respond to constructive criticism depending on whether the feedback-giver demonstrated IH—defined as acknowledging one’s limitations and valuing learning. We focused on outcomes related to intellectual (or epistemic) openness in the context of writing, including self-focused state IH (acknowledging one’s own knowledge limitations), other-focused IH (valuing the insights of a peer expert), corrigibility (comfort with being corrected), feedback engagement, and attitudes toward future academic help-seeking in writing (AHS).

In Experiment 1, participants received feedback from a peer who conveyed IH through a brief self-descriptive statement. This subtle manipulation …

Molecular Mechanisms Of Kynurenine-Mediated Lifespan Regulation In Yeast, Ryan E. Counterman Jobb

Theses and Dissertations

The kynurenine pathway is a highly conserved pathway that acts as the primary pathway for tryptophan catabolism and has been found to be involved in lifespan regulation across many diverse organisms. Caloric restriction (CR) is the only known dietary intervention to date that both increases the mean lifespan and the health span of multiple organisms, although the molecular mechanisms of these effects are not fully understood. There are known and sometimes contradictory relationships between the kynurenine pathway activity and the life- extending effect of CR but the crosstalk between the two is not well characterized. Understanding these relationships could lead …

Group Flow Perceptions And Dynamics As Compared To Taxonomy And Integrative Group Flow Theory, Karen E. Wirick

Theses and Dissertations

This qualitative study investigated group flow through a team-building exercise with 18 professionals, examining participants’ and an observer’s perceptions of flow in social contexts. Analysis of interviews and observer notes identified eight themes: Sensory Network of Shared Experience, Adaptive Group Identity and Performance, Goal-Skill-Motivation Alignment, Essential Social Dynamics, Calm Intensity, Synchrony and Engagement Patterns, Spontaneous Collective Celebration, and Observer Integration. These themes revealed that flow in groups manifests as dynamic forces in constant motion. When compared to an emergent Taxonomy and the Integrative Group Flow Theory (IGFT), findings aligned more closely with IGFT's conceptualization of flow as a holistic balancing …

Human Factors Matter: The Intersection Of Cybersecurity Governance, And Culture In Risk Management Of Critical Infrastructure, Prince Abubakari

Theses and Dissertations

In the 21st century, cybersecurity threats have evolved into pressing socio-technical issues, with significant implications for the safety and stability of global critical infrastructure. This dissertation explores the intersection of cybersecurity governance and culture in risk management of national critical infrastructures, defined as essential systems and assets, whether physical or virtual, that are vital to the security, public health, safety, economy, or any combination thereof, and the disruption of which would have a debilitating impact on a nation. The study delves into how human factors like organizational culture and governance mechanisms interplay to influence cybersecurity outcomes. The research adopts a …

Obstacles And Supports As Experienced By Foster Youth In Higher Education: Ventura County Community College District, Breanna Webb

Theses and Dissertations

This qualitative phenomenological research study assesses the obstacles faced by foster youth and the support available to them while attending the Ventura County Community College District. As it currently stands, about four and a half percent of foster youth in the United States go on to earn a college degree. Very little research has been done to explore the effectiveness and outcomes of the support offered to foster youth. Data for this research study was collected using the General Self-efficacy scale and structured interviews. Each of the ten participants was given a demographics survey and a Self-Efficacy scale survey and …

Synthesis And Characterization Of Silicon-Containing Ternary Transition Metal Borides For High Performance Applications, Godswill Ngige

Theses and Dissertations

Binary borides are well known for their exceptional mechanical and thermal properties, including high strength, high melting points, outstanding hardness, and excellent chemical stability, making them suitable for high-temperature structural applications such as components in hypersonic vehicles, jet engines, nose cones, and the leading edges of aircraft. Despite these advantages, they are inherently brittle and suffer from low fracture toughness, limiting their ability to absorb impact or resist crack propagation.

To this end, attention shifted to ternary transition metal borides which are materials composed of a transition metal, boron, and a third element. These ternary compounds exhibit a broader range …