Digital Commons Network^™

Periodic Trends In The Electronic And Magnetic Structure Of Superatomic 3d Transition Metal Chalcogenide Clusters, Gabriel Bohannon

Theses and Dissertations

We have systematically investigated the electronic structure of octahedral transition metal chalcogenide clusters, TM₆S₈(CO)₆, in which the transition metal atoms are from the 3d series in order to identify if periodic properties emerge. We were motivated by the identification of closed electronic shells with electron counts of 96, 100 and 114 in similar clusters from the 4d and 5d transition metal series. Further motivation was the finding of a dual-shell closing in the Fe₆S₈(CN)₆^5- cluster. This cluster is stabilized with a large spin magnetic moment due to the …

Rare Variant Analysis Of Electronic Health Record-Defined Major Depressive Disorder In The All Of Us Research Program, Stephen Emil Vieno

Theses and Dissertations

The underlying pathogenesis of MDD remains poorly understood, with multiple competing hypotheses regarding its exact etiology. As a heterogeneous disorder with relatively low heritability, large-scale genome-wide association studies of MDD have relied on increasingly large sample sizes to identify common genetic variants associated with the disorder. However, the rare variant genetic architecture of MDD is still largely unknown. The aim of the present analysis was to use the AoU—a United States-based biobank that integrates healthcare records from over 50 healthcare systems and possesses whole genome sequencing data for participants—to perform a gene set–based analysis of MDD. This analysis presented several …

Modeling Vaccination Strategies And Intervention Impacts On Infectious Disease Dynamics, Elizabeth B. Amona

Theses and Dissertations

This dissertation explores how mathematical and statistical modeling can inform vaccination strategies and evaluate the impact of interventions during infectious disease outbreaks. Motivated by the challenges observed during the COVID-19 pandemic, the research integrates compartmental modeling, Bayesian inference, and agent-based simulation to assess policy effectiveness and disease control across varying contexts. The first study develops a SEIRDV model that incorporates government interventions and vaccination rollout to examine COVID-19 dynamics in Qatar. A Bayesian approach is used to estimate parameters and compute time-varying transmission rates. The model captures shifts in transmission following policy changes and quantifies the reduction in deaths attributable …

Exploring Collaboration In Interdisciplinary Ei/Ecse Programs: A Qualitative Study On Service Provider Preparation, Meagan Dayton

Theses and Dissertations

Interdisciplinary preparation is critical for early childhood special education professionals, yet few programs are designed to support such collaboration across disciplines. This study aimed to explore how interdisciplinary EI/ECSE preparation programs support collaboration. The study was guided by the following research questions: (1) How are program components designed to support the development of collaboration skills? (2) What is the student experience of collaboration in the program? (3) What connections exist between program components, student experiences, and the development of collaboration skills? Using a qualitative multiple-case study approach grounded in ecological systems theory, data were collected from program documents and interviews …

Bugs In The Flux: Links Between Arthropod Diversity And Spatial Variation Of Soil Respiration In A Temperate Forest, Erin-Darby H. Mcclain

Theses and Dissertations

Soil respiration (Rs) is the largest terrestrial flux of carbon (C) to the atmosphere, with heterotrophic contributions to Rs varying spatially and temporally. While microbes are the primary and most thoroughly studied source of soil heterotrophic respiration (Rh), contributions from higher trophic organisms, including arthropods, are rarely quantified and poorly understood. Arthropod abundance and diversity correspond with variation in soil microclimate, which is influenced by site factors including canopy structure, site productivity, and disturbance. However, the extent to which these site factors influence arthropod abundance and diversity, and consequently, spatial variation in Rs is not known. The objective of our …

Automated Treatment Planning Framework For Cervical Cancer In Brachytherapy, Suman Gautam

Theses and Dissertations

Brachytherapy (BT) is a critical treatment modality for cervical cancer that delivers ionizing radiation directly to the tumor using intracavitary (IC) and/or interstitial (IS) applicators. In high dose-rate (HDR) BT, a remote afterloader guides the radioactive source to specific dwell positions for defined durations, known as dwell times, allowing for a conformal dose to the tumor while minimizing exposure to surrounding organs at risk (OAR). However, due to the inherent nature of ionizing radiation, some dose to OARs is unavoidable, creating a fundamentally conflicting objective in treatment planning: maximizing tumor coverage while minimizing OAR dose. This characterizes the problem as …

Plasmon-Assisted On-Chip Integration Of Quantum Emitter For Scalable Quantum Networking, Samprity Saha

Theses and Dissertations

In recent decades, quantum theory has sparked a revolutionary outlook on our long-standing perception of information processing and communication technologies. Photon-based quantum systems, relying on single photons governed by quantum mechanics, hold immense promise for quantum networks due to their resilience against decoherence and fast propagation speeds. However, challenges persist in realizing practical quantum networks, including the need for scalable, robust, and cost-effective quantum light. To address these challenges with classical photonic concepts, this thesis focuses on a plasmon-assisted approach for on-chip integration of single-photon sources. The study aims to develop a scalable solution for integrating quantum emitters on-chip, leveraging …

An Adaptive Method For Covariate Balancing In Block Randomized Clinical Trials, Ren Rasnick

Theses and Dissertations

Clinical trials are randomized in part to limit allocation bias, but also to ensure comparability between treatment arms for a baseline variable of concern. Comparable with regard to a baseline variable of concern is necessary for the validity of statistical methods. However, comparability is not guaranteed for trials of any size and is even more likely in trials with < 200 total participants. We propose a new method for adapting the allocation of participants in a sequentially allocated two-armed study with a small sample size to better ensure comparability.

The proposed method calculates the expected final imbalance (lack of comparability) based on the current participant values. Unlike several other methods, our method ensures the final desired sample size for each treatment arm, utilizes the expected final imbalance, increases comparability between …

How To Touch Your Bile, Aleckxi Dorhofer

Theses and Dissertations

I have been reflecting on my past decade-long struggle with anorexia and bulimia. Reinterpreting this experience through the lenses of mythology and magic, I have constructed these Stygian carcasses (from the river Styx, which serves to separate the living and the dead) using my own bodily proportions in muslin, an intermediary material which requires transformation. In this work, I utilize these forms to symbolically rot for me as my body did, performing a type of sympathetic magic (magic worked from afar on another person) on myself, extending my life and allowing all which occurs between birth and death to affect …

Associations Between Community Violence Exposure And Internalizing Outcomes: The Moderating Role Of Racial Identity, Kimberly S. Lazarus

Theses and Dissertations

Community violence continues to be an ongoing public health crisis, driven by structural inequities and systemic disinvestment. Due to historical discriminatory policies and ongoing systemic barriers, Black adolescents are disproportionately affected, placing them at heightened risk for adverse mental health outcomes, particularly post-traumatic stress symptoms (PTSS) and depressive symptoms. While existing literature highlights racial identity as a promotive factor linked to a lower likelihood of negative health outcomes, less is known about its protective role in buffering the mental health effects of adversity. There is an increasing call for public health researchers to consider racial-ethnic factors as potential moderators in …

Characteristics Of Permanent Teeth Undergoing Surgical Endodontic Evaluation: A Retrospective Study, Yasamin Mojarad

Theses and Dissertations

Objective: This study examines the pre-surgical clinical and radiographic characteristics that may influence the choice of apicoectomy over nonsurgical retreatment in a more detailed approach, focusing on the clinical factors that come into the evaluation phase. We hypothesize that there are certain patterns observed through a pre-operative CBCT that may impact the decision for surgical intervention. The study aims to assess patterns in the decision-making in surgical treatment planning.

Methods: Retrospective review analyzing 142 cases treated or planned for apicoectomy by VCU endodontic residents. Data collected from CBCT and PA radiographs included: restorations, quality of prior root canal treatment, presence …

Hyperreality Ain’T Really Real: Postmodernity, Social Media, & Blackness, Micah White

Theses and Dissertations

This qualitative study examines the interplay between postmodernity, social media, and African American identity formation through focus group analysis and Grounded Theory methodology. The research investigates how social media’s postmodern features—fragmentation, hyperreality, commodification, and context collapse—shape identity development among African Americans, who historically navigate cultural disruption and systemic racism. Data from semi-structured interviews with two generational focus groups revealed that participants engaged in sophisticated identity curation to balance authenticity and protection in racially charged digital spaces. Key findings highlight the tension between empowerment and marginalization, as social media served as both a platform for racial affirmation and a source of …

A Multimethod Approach To Examining Racial Coping Socialization Among Black Adolescents, Rachel J. Davis

Theses and Dissertations

Experiences of racial discrimination are pervasive in the lives of Black youth and result in race-related stress. Racial coping has been found to mitigate the negative physical and mental health effects of racial discrimination; thus, it is imperative that we understand the process that Black youth undertake to navigate racialized experiences by utilizing a person-centered approach. Additionally, parents socialize their Black youth to navigate racialized experiences, indeed, previous research has investigated racial and emotion socialization as separate phenomena, however, this does not reflect the integrated nature by which racial and emotion socialization processes are interconnected during parents’ and youths’ discussions …

A Mixed Methods Study: High School Teachers’ Perspectives On Incorporating Mindful Artmaking In Their Classroom As A Mental Health Resource, Sherry A. Bosarge

Theses and Dissertations

Mental health concerns and the need for mental health resources for high school students continue to rise in Virginia. Some of the reported benefits to the current mental health services and resources offered in Virginia schools are increased academic outcomes, attendance, and positive behaviors. The reported barriers to current mental health services and resources are lack of participation, lack of training, time constraints, funding, and resources. This explanatory sequential mixed methods study examined high school teachers’ perspectives on the benefits and barriers to incorporating mindful artmaking in their classrooms as a mental health resource at a local high school. This …

Still An Athlete? An Exploration Of Athlete Identity, Body Appreciation, And Psychological Flourishing In Middle-Aged Former Collegiate Athletes, Kelly Furr

Theses and Dissertations

Collegiate athletes, upon retirement, are encouraged to develop other interests outside of sport to form a well-rounded identity. Yet middle-aged people often struggle to complete recommended strength training and exercise guidelines, and many continue to struggle with body appreciation and psychological well-being beyond adolescence and young adulthood. Using a cross-sectional survey design, 482 former NCAA athletes completed the Athlete Identity Measurement Scale (AIMS), Exercise Identity Scale (EIS), Body-Appreciation Scale (BAS-2), and Flourishing Scale (FS). The study used Structural Equation Modeling (SEM) to determine if athlete or exercise identity positively affects body appreciation and psychological flourishing through the mediating variable of …

A Mixed Method Case Study Of Leadership For Change: Authentic Transformational Leadership In A Local Baptist Church, Hui Sun

Theses and Dissertations

This convergent parallel mixed methods case study explores how a local Baptist church navigated organizational change during and after the COVID-19 pandemic through the lens of authentic and transformational leadership. Grounded in organizational leadership and open systems framework of organizational change, the study examined two primary hypotheses: (1) RBC demonstrated an authentic transformational leadership paradigm in its change processes since 2020, and (2) this paradigm significantly and positively influenced perceived leadership effectiveness.

Qualitative data were collected through semi-structured interviews with six leaders (three pastors, one minister, one staff leader, and one deacon) and 11 raters (five lay leaders, five congregants, …

Using Habituation And Affective Forecasting To Distinguish When The Passive Enjoyment Of Harm Begets The Active Pursuit Of Aggression, Drew M. Parton

Theses and Dissertations

Understanding the antecedents and impellers of aggression is key to preventing violence, and individual differences have been identified as some of the key factors of interest in the study of aggression. Antisocial personality traits such as psychopathy, Machiavellianism, Narcissism, and Sadism have received considerable focus from researchers. Among these traits, Sadism stands above them all as arguably the most malevolent of all trait constructs in psychology. Sadism shows the strongest correlations with aggression among malevolent traits and is uniquely linked to unprovoked aggression, even when it is costly. Sadism thus represents an extreme risk factor for aggression, and studying its …

Brute Gamification, Catherine Chen

Theses and Dissertations

Digital platforms are surreptitious structures that gamify the ways in which we engage and exchange. They dictate every step of our journeys even as we navigate onward with a sense of absolute agency. The harder that we try to win, the more the platform will win!

In Brute Gamification, I employ image-based installation and performance to unravel the terms and conditions with which these platforms dictate our lives. A literal platform supports a series of image-games, all of which are about to end in a draw. Through prescribing the user to a designated path to focus on this non-ending as …

Facile Synthesis Of Gold, Copper, And Silicon Nanostructures By Laser Ablation In Liquid, Nicholas Simpson

Theses and Dissertations

Metal nanoparticle (NP) synthesis is a continually evolving area of research, owing to the widespread application of NPs in fields such as catalysis, drug delivery, and biosensing. Compared to bulk metal material, NPs contain a larger proportion of surface atoms and exhibit unique optical properties, thus making them ideal for applications where maximizing surface interactions is key. Moreover, their compositions can be altered in several different ways, as evidenced by metal alloy, core/shell, supported, and defective NPs. While conventional synthesis methods are capable of producing NPs in large quantities, they often require conditions of high temperature and pressure, strong reducing …

Knowing By Heart: Philosophical Dimensions Of Humanistic Mathematics Education, Catherine Henney

Theses and Dissertations

This project seeks to revive interest in late twentieth century humanistic mathematics education (HME) so that its principles might cross the boundary of higher education and settle in corners of the K-12 math education space. In particular, HME’s theme of teaching math humanistically directs attention to features and phenomena that bear strongly on students’ daily classroom experiences. Personhood, agency, inquiry, meaning, environment, feelings, relationships: these elements invite a more thorough meditation and philosophical analysis. Though it is a largely philosophical endeavor, this project is enlivened by classroom vignettes and case studies that bring practical relevance to HME’s core principles. Chapters …

Scopolamine-Induced Modulation Of Serotonin And Dopamine Transporters Activity: Behavioral And Molecular Insights Into Rapid Antidepressant Action, Deepak Karunakaran

Theses and Dissertations

Major depressive disorder (MDD) affects over 350 million individuals worldwide and is characterized by profound dysregulation of serotonin (5-HT) and dopamine (DA) systems that govern mood, reward processing, and motivation. The serotonin transporter (SERT) and dopamine transporter (DAT), both dynamically regulated through phosphorylation, serve as critical determinants of synaptic monoamine signaling. Despite decades of therapeutic development, current antidepressants require 4-6 weeks to achieve efficacy, and approximately one-third to half of patients develop treatment-resistant depression. The emergence of rapid-acting antidepressants like ketamine represents a paradigmatic shift, demonstrating symptom relief within hours; however, ketamine's therapeutic potential remains constrained by abuse liability, dissociative …

Therapy-Induced Senescence In Cancer: Developing Senolytic-Based Combination Strategies To Delay Re-Emergence Of Triple-Negative Breast Cancer, Eesha Chakraborty

Theses and Dissertations

Therapy-induce senescence (TIS) represents a major biological outcome of many anticancer treatments and is increasingly recognized as a strategic vulnerability in triple negative breast cancer, which is a highly aggressive subtype with limited therapeutic options and frequent relapse. Here, we probed TIS as a primary cellular response that may ultimately compromise long-term outcomes using standard chemotherapeutic agents in TNBC as well as the antibody-drug conjugate sacituzumab govitecan (SG). Both chemotherapy and SG reliably induced pronounced senescence across TNBC models, yielding durable growth arrest, however, also generating a persistent reservoir of viable tumor cells capable of eventual proliferative recovery, a hallmark …

Advanced Air Preheater Sealing Systems For Enhanced Efficiency And Reliability In Thermal Power Plants, Pavan Kumar Ravulaparthy

Theses and Dissertations

Global electricity generation still relies heavily on thermal power plants, which consume vast amounts of fuel and emit significant amounts of carbon dioxide. A major but often overlooked source of inefficiency in these plants lies within the rotary regenerative air preheater (RAPH), a critical heat-exchange component where air leakage can exceed 20% in aging units. This leakage increases fuel consumption, parasitic fan power, and CO₂ emissions, while degrading boiler reliability.

This research introduces advanced adaptive sealing systems designed to mitigate these losses by dynamically compensating for rotor eccentricity, thermal distortion, and wear under harsh operating conditions. Brush seals, composed of …

Machine Learning-Driven Optimization For Utility-Scale Quantum Optimization, Bao Tran

Theses and Dissertations

Hard combinatorial optimization problems, often mapped to Ising models, promise potential solutions with quantum advantage but are constrained by limited qubit counts in near-term devices. We present an innovative quantum-inspired framework that dynamically compresses large Ising models to fit available quantum hardware of different sizes. Thus, we aim to bridge the gap between large-scale optimization and current hardware capabilities. Our method leverages a physics-inspired GNN architecture to capture complex interactions in Ising models and accurately predict alignments among neighboring spins (aka qubits) at ground states. By progressively merging such aligned spins, we can reduce the model size while preserving the …

Linking Disturbance & Macrophyte Colonization–Extinction Dynamics To Invasion Success & Community Assembly: Integrating Population, Community, & Landscape Perspectives, Joshua T. Armstrong

Theses and Dissertations

Aquatic plants, macrophytes, are foundational components of freshwater ecosystems, influencing abiotic conditions, providing habitat structure, and shaping biodiversity and community assembly processes. Their role is particularly critical in dynamic systems where disturbance regimes and colonization processes interact to shape community patterns and species distributions. Despite their ecological importance, macrophytes remain underrepresented in theoretical and applied studies of metacommunity dynamics and invasion ecology, especially in natural systems experiencing frequent environmental fluctuations. Here we aim to elucidate how macrophytes influence and respond to spatial and temporal variation in aquatic ecosystems, with a particular focus on colonization-extinction dynamics, invasion success, and community assembly. …

Effectiveness Of Immersive Virtual Reality Combined With Task-Specific Training On Hemiplegic Arm Function Following Stroke: A Single Case Series Study, Rahsaan J. Holley

Theses and Dissertations

Motor recovery of the arm following a neurological injury is a common goal of the rehabilitation process for individuals impacted by the condition . Due to the long-term functional implications of impaired arm movement, individuals are often trained to use compensatory strategies to complete functional tasks without incorporating the weakened limb. While compensatory strategies offer stroke survivors the opportunity to regain a level of independence, such approaches fail to directly address the underlying causes of the disability (i.e., limited range of motion, decreased strength, poor coordination, motor planning difficulties) which can unfortunately result in long-term impairment and functional disability.

Motor …

Swarming Segregation: Leveraging Swarm Intelligence And Regionalization As Instruments For School District Desegregation, Jeffrey Wooten

Theses and Dissertations

Even after Brown led to the South briefly having the most diverse schools in the nation, schools throughout the Northeast have remained the most segregated in the nation for decades. While federal jurisprudence has made compelling desegregation pursuant to the Equal Protection Clause more challenging, New Jersey has a particularly favorable landscape to address severe segregation. With a highly diverse, densely populated public enrollment, favorable state constitutional precedent, and a history of successfully compelling desegregation, New Jersey is fertile ground exploring regional desegregation. Scholars, judges, and even plaintiffs in ongoing litigation (Latino Action Network v. N.J.) have called for New …

Place, Culture, And Care: A Socioecological Examination Of Type 2 Diabetes Among Hispanics In The U.S., Danielle Montoya

Theses and Dissertations

Introduction: Type 2 diabetes (T2D) disproportionately affects U.S. Hispanic populations. This dissertation examined whether structural determinants fundamentally drive T2D disparities among Hispanics, with attention to within-group racial heterogeneity.

Methods: Three studies utilized nationally representative data. Study 1 examined neighborhood segregation and ethnic enclave residence associations with T2D using restricted NHANES data (2011-2018, n=5,056). Study 2 investigated acculturation and T2D associations using restricted NHANES data (2011-2018, n=4,540). Study 3 analyzed patient-provider racial/ethnic concordance and adequate diabetes care using MEPS data (2008-2021, n=17,138).

Results: Structural factors demonstrated primacy across all studies. Neighborhood segregation (aOR=1.17, p>0.05) and ethnic enclave residence showed no …

Unraveling The Reactivity Of Nitrate Ester Explosives: Insights From Femtosecond Time-Resolved Mass Spectrometry And Computational Chemistry, Erica Britt

Theses and Dissertations

This dissertation uncovers the ultrafast molecular mechanisms underlying the decomposition of nitrate ester explosives—nitroglycerin (NG), ethylene glycol dinitrate (EGDN), and amyl nitrate—through the integration of femtosecond time-resolved mass spectrometry and advanced computational chemistry. Although these compounds play fundamental roles in both military and civilian contexts, the precise molecular dynamics governing their pronounced reactivity and impact sensitivity have remained inadequately characterized. Our research establishes that low O–NO2 bond dissociation energies are the primary driver of ultrafast fragmentation and high reactivity in all three esters. The distinctive molecular architectures of these esters dictate their explosive properties: NG’s tri-nitrate configuration leads to exceptional …

Exploring The Role Of Host Immune Responses And Bacterial Sensory Pathways In The Development Of Treponema Denticola-Mediated Periodontal Disease, Annie N. Hinson

Theses and Dissertations

Periodontitis is a chronic inflammatory disease driven by dysbiotic microbial communities and maladaptive host responses. Treponema denticola, a spirochete pathobiont, is strongly associated with disease severity. However, the molecular mechanisms underlying its interaction with host tissues and regulation of virulence remain incompletely understood. This work examines both the epithelial immune responses and bacterial transduction systems that shape T. denticola pathogenesis. Transcriptomic analysis of gingival keratinocytes revealed IL-36γ as the most highly induced cytokine following infection with T. denticola. Functional studies demonstrated that IL-36γ induction occurs in a dose- and time-dependent manner through TLR2/6 signaling, requiring the NF-κB, PI3K/Akt, and …