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Propelling Whole-Cell Biosensor Creation By Leveraging Gene Fusion To Assemble Synthetic Functional Transcription Factors For The Detection Of Biomarkers, Samuel J. Verzino
Propelling Whole-Cell Biosensor Creation By Leveraging Gene Fusion To Assemble Synthetic Functional Transcription Factors For The Detection Of Biomarkers, Samuel J. Verzino
Theses and Dissertations
Biosensors are analytical devices that leverage biological modules for the detection of molecules of interest. As customizable tools designed to aid in a wide array of diagnostics, these instruments are rapidly advancing the field of synthetic biology. While varied in their construction and purpose, biosensors are ultimately concerned with converting a physicochemical stimulus into a detectable signal. Among the many existing variants, whole-cell biosensors (WCBs) stand out due to their versatility and engineering potential. WCBs are a type of biosensor in which a physiologically active cell sustains an array of biomolecular elements - receptors, transporters, regulators, etc. - capable of …
Breath, Body, And The Blank Page: An Autoethnographic Approach To Embodied Writing Practices In First-Year Writing, Kristen Garramone Hoffman
Breath, Body, And The Blank Page: An Autoethnographic Approach To Embodied Writing Practices In First-Year Writing, Kristen Garramone Hoffman
Theses and Dissertations
This dissertation explores how somatic awareness and trauma-informed pedagogies can be integrated into the teaching of writing. Drawing from autoethnography and pedagogical theory, it proposes that writing is not a purely cognitive act but a deeply embodied process, one shaped by the physiological and psychological dimensions of lived experience. Using autoethnography as both method and praxis, the study centers the author’s experiences of trauma, grief, and healing to investigate how body-based practices such as breathwork, visualization, and mindfulness can support writing, particularly for students navigating stress, anxiety, or disconnection from their academic identities. Chapter One situates the research within literature …
As I Type: An Autoethnography Of Italian (Sicilian) Family Literacies Across Generations In The United States, Kailyn Nicole Giaccone
As I Type: An Autoethnography Of Italian (Sicilian) Family Literacies Across Generations In The United States, Kailyn Nicole Giaccone
Theses and Dissertations
This dissertation aims to investigate the racialization of my own family through the examination of migration and citizenship documents, primary sources, and oral histories as told by those who were present for or knew those present for events in question. Participants, including myself, were members of the same family, identified as either male or female, and ranged in age from 30 years to 80 years old. Participants were either monolingual English speakers or multilingual in English, Italian, and/or Sicilian. The methodology used to accomplish this research was autoethnography, which allowed the use of traditional database research, archival examinations of primary …
The Long Shadow Of Pride And Prejudice On Contemporary Fictions Of Arranged Marriage And Marriages Of Alliance, Candice Belluscio
The Long Shadow Of Pride And Prejudice On Contemporary Fictions Of Arranged Marriage And Marriages Of Alliance, Candice Belluscio
Theses and Dissertations
This dissertation is an examination of the conflicts between arranged marriage and companionate marriage in selected contemporary Anglo-Indian novels and novels about Orthodox Judaism. The project’s guiding focus is how modern ideals of independence and choice in marriage coexist simultaneously with older ideals of marriage as family or personal “alliance.” The dissertation has a historical chapter that shows that although ideals of companionate marriage have become norms of 20th century western society and literature, the term “companionate marriage” is a recent invention and convention, and that various degrees and forms of arranged marriage, or marriages of alliance, continue despite their …
Ripples Of Support: A Mixed Methods Study Of Bystander Behavior In The Context Of Sexual Assault Among College Students, Miranda Levy
Ripples Of Support: A Mixed Methods Study Of Bystander Behavior In The Context Of Sexual Assault Among College Students, Miranda Levy
Theses and Dissertations
Emerging adulthood represents a period of elevated risk for sexual assault (SA), particularly among college students. Students are not only potential victims or perpetrators but also bystanders—individuals who may witness or become aware of risky or harmful situations and must decide whether and how to respond. Understanding what influences students’ decisions to intervene as bystanders in SA contexts is critical to improving peer responses and fostering safer campus environments. This study used a concurrent mixed methods design to examine how college students’ knowledge of campus SA policies, personal history of victimization, prior experiences receiving help, and SA disclosure reactions relate …
Investigation Of The Binding Mechanisms Between Naphthenic Acids And Humic Acid Using Raman Spectroscopy And Computational Modeling, Jaelyn N. Palmer
Investigation Of The Binding Mechanisms Between Naphthenic Acids And Humic Acid Using Raman Spectroscopy And Computational Modeling, Jaelyn N. Palmer
Theses and Dissertations
The oil sand regions in Alberta, Canada have proven to be costly to the environment despite its economic benefits. The toxins produced during oil processing are sent to tailing ponds to be recycled, though often leaking into nearby waterways and soil. Naphthenic acids, NAs, are one of the most common toxins produced and have shown to be toxic to aquatic life, animals, and humans. As there is dissolved organic matter in tailing ponds and surrounding environments, tailing ponds often lead to NAs coming in contact with organic material. Humic acid, HA, is a major soil component that has been suspected …
Operation Airlift Africa: American Education And The Development Of Future Leaders From British Colonies In East And Central Africa, David N. Gachigo
Operation Airlift Africa: American Education And The Development Of Future Leaders From British Colonies In East And Central Africa, David N. Gachigo
Theses and Dissertations
In the late 1950s and early 1960s, over 800 students from British East and Central Africa gained access to American education through Operation Airlift Africa (OAA), a visionary initiative led by Kenyan trade unionist and politician Tom Mboya. Funded by private American donors, including Senator John F. Kennedy, and supported by scholarships from U.S. institutions, the program enabled African students to attend high schools, colleges, and universities in North America, mostly in the United States. This dissertation explores the impact of OAA on educational access for colonial subjects and its role in shaping future African leadership. The study argues that …
Sustained Effects Of Neurofeedback On Children & Adolescents With Adhd: A Meta-Analysis, Dannielle A. Stephen
Sustained Effects Of Neurofeedback On Children & Adolescents With Adhd: A Meta-Analysis, Dannielle A. Stephen
Theses and Dissertations
Attention-deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder diagnosed in the United States, with the most common form of treatment being psychostimulant medication. In the recent years there has been a growing concern among parents about starting their children on medication from a young age, prompting researchers to look at alternative methods. This will me a meta-analytic review of neurofeedback treatments to see if they are a feasible method in improving core behavioral symptoms and executive functions. All articles included in the review contained follow-up periods of 6 months or greater. There was a total of 468 participants across …
Latent Transition Analysis Of Prosocial Behavior And Physical Aggression In Toddlerhood, Annette Schieffelin
Latent Transition Analysis Of Prosocial Behavior And Physical Aggression In Toddlerhood, Annette Schieffelin
Theses and Dissertations
The current study is the first to apply Latent Transition Analysis (LTA) to examine short-term stability and change in toddlers’ physical aggression and prosocial behavior, using a person-centered, longitudinal approach to capture behavioral heterogeneity and stability during a critical developmental period. Mothers of 333 toddlers (18 or 24 months at Time 1; 21 or 27 months at Time 2) completed reports of provoked and unprovoked aggression, prosocial behaviors (helping, sharing, comforting), temperament, and parenting practices. Four profiles emerged consistently across time: High Aggression / Low Prosocial, Low Aggression / Average Prosocial, Low Aggression / High Prosocial, and Average Aggression / …
Qualitative Analysis Via Network Models Of Human Dynamin-1 Throughout Gtp Hydrolysis, Kevin Brian Schulman
Qualitative Analysis Via Network Models Of Human Dynamin-1 Throughout Gtp Hydrolysis, Kevin Brian Schulman
Theses and Dissertations
This thesis aims to elucidate the molecular mechanisms by which nucleotide binding dictates the intrinsic dynamics and to understand the functional conformational changes of Human Dynamin-1 during the GTP hydrolysis cycle through the use of Elastic Network Models (ENM). A comprehensive understanding of this process is crucial given dynamin's role in clathrin-mediated endocytosis (CME). The research utilized both experimentally derived crystal structures and AlphaFold-predicted structures of dynamin, specifically examining the GTPase and Bundle Signaling Element (BSE) domains across nucleotide-free, GTP-bound, GDP-bound, and transition states. The essential features of the research methodology involved a multi-scale computational approach. Qualitative analyses were performed …
Sonic Futures: Exploring Podcasting, Artificial Intelligence, And The Evolving Landscape Of Composition, Grant David Crawford
Sonic Futures: Exploring Podcasting, Artificial Intelligence, And The Evolving Landscape Of Composition, Grant David Crawford
Theses and Dissertations
This dissertation investigates podcasting and audio projects as multimodal practices in composition, analyzing how audio-based assignments both challenge and reproduce traditional writing norms. Drawing from personal teaching experience and a dataset of publicly accessible assignment prompts, rubrics, and instructional guides, the study examines how podcast projects are framed, assessed, and implemented in higher education. While often promoted as creative and accessible alternatives to essays, these assignments frequently replicate the same thesis-driven, rubric-centered, and exclusionary structures that define conventional academic writing. Through a cross-textual analysis of fifteen podcast rubrics and fifteen assignment prompts, this project identifies recurring patterns, including paradoxical expectations …
Embracing An Online Literary Identity: How Booktok Makes Literature More Accessible, Elizabeth Kaufmann
Embracing An Online Literary Identity: How Booktok Makes Literature More Accessible, Elizabeth Kaufmann
Theses and Dissertations
In this thesis I examine conversations that occur on TikTok’s literary corner, “BookTok.” My research involves focusing on the multimodality of BookTok, following comment sections and search options, as well as analyzing the components of the videos themselves. BookTok content creators focus on these features in order to spark literary conversation in an approachable way. These influencers heavily sway the app itself and the books being recommended. Extending my research beyond BookTok influencers, this essay seeks to understand the value of influencer backing on products towards their social legitimacy. Some users on TikTok are not fans of how the algorithm …
Severity Profiles Of Preschool-Aged Children And Their Associations With Maternal Help-Seeking: A Latent Profile Analysis, Samuel T. Jackson
Severity Profiles Of Preschool-Aged Children And Their Associations With Maternal Help-Seeking: A Latent Profile Analysis, Samuel T. Jackson
Theses and Dissertations
Parents of preschoolers are more likely to seek treatment for childhood depression compared to anxiety and behavioral disorders. Atypicality and stability have been implicated in relation to help-seeking, but it is not known how they differ between disorders and whether such differences impact help-seeking. The current study grouped mothers based on their atypicality and stability appraisals across disorders; tested for differences in appraisals between disorders; and then tested for differences in help-seeking based on group membership. Participants were 272 adult mothers of preschool-aged children. Mothers read a series of vignettes describing preschool-aged children with depression, anxiety, and ADHD, and then …
Recognizing Speculative Literature: Conceiving Identity In The Archives Of Enslavement, Gabriella Greco
Recognizing Speculative Literature: Conceiving Identity In The Archives Of Enslavement, Gabriella Greco
Theses and Dissertations
One of the key problems of the archive of enslavement, borne out of the violent erasure of enslaved identities, is the struggle to reconstruct and honor those lost identities. Recognizing Speculative Literature: Conceiving Identity in the Archives of Enslavement investigates postcolonial archival processes and the resulting documents to identify a spectrum of speculative literary genres that can be used to supplement traumatic archival erasures, often of female voices and identities, to further understand the power dynamics. To clarify, I use the term ‘speculative literature’ here to refer to a mode of literature that relies on the few fragments that may …
How Therapists’ Perceptions Impact Disseminating And Implementing Trauma-Focused Cognitive-Behavioral Therapy, Maddi R. Gervasio
How Therapists’ Perceptions Impact Disseminating And Implementing Trauma-Focused Cognitive-Behavioral Therapy, Maddi R. Gervasio
Theses and Dissertations
In the United States, 60% of youth experience a traumatic event before the age of 18 (Lawrence-Sidebottom et al., 2024) and childhood trauma is associated with a range of psychopathology. Although evidence-based therapies like Trauma-Focused Cognitive-Behavioral Therapy (TF-CBT; Cohen et al., 2017) are available, only 14-22% of traumatized youth receive trauma-specific practices during treatment (Borntrager et al., 2013). Barriers to disseminating and implementing TF-CBT and similar interventions exist at the micro (e.g., therapist and client) and macro (e.g., systemic) levels (e.g., Gervasio & Herren, 2020). Emerging research focused on training in trauma therapists found that therapists’ negative perceptions about the …
Predicting Price Movements Of The S&P 500 Using Conventional And Alternative Market Indicators, Patrick M. Scarborough
Predicting Price Movements Of The S&P 500 Using Conventional And Alternative Market Indicators, Patrick M. Scarborough
Theses and Dissertations
This thesis investigates whether integrating alternative data sources with conventional financial indicators enhances S&P 500 forecasting accuracy in modern financial markets characterized by increased complexity and rapid information flows. The study analyzes daily S&P 500 returns using twelve predictor variables comprising conventional indicators (VIX volatility index, WTI crude oil, gold futures, AAA bond yields, Federal Funds Rate, Treasury yield spreads) and alternative data sources (Bitcoin returns, Daily News Sentiment Index, Indeed job postings, Economic Policy Uncertainty Index) across 1,341 observations from February 2020 to June 2025. The methodology employs ordinary least squares regression and ARIMAX(5,5) modeling with rigorous preprocessing including …
Evaluating Task Demands And Task Characteristics Analysis Among School Psychologists, Alessandra Miceli
Evaluating Task Demands And Task Characteristics Analysis Among School Psychologists, Alessandra Miceli
Theses and Dissertations
Cognitive ability assessments are central to psychoeducational evaluations, informing decisions regarding interventions and supports for students. While cognitive assessment theories have historically emphasized quantitative data in score interpretation, they have increasingly reflected the need to consider qualitative information, a longstanding tenet of neuropsychological assessment. Frameworks such as the Integrated School Neuropsychology/Cattell-Horn-Carroll (SNP/CHC) Model and the Cognitive Hypothesis Testing (CHT) Model emphasize the importance of analyzing subtest task demands and task characteristics to explain unexpected score discrepancies. Despite these recommendations, little is known about school psychologists’ familiarity with these analyses and their use in the interpretation of test performance. This study …
Sustainability Risk In Guyana’S Oil Sector: An Analytical Framework For Balancing Environmental And Economic Impacts, Kayla B. Moonsammy
Sustainability Risk In Guyana’S Oil Sector: An Analytical Framework For Balancing Environmental And Economic Impacts, Kayla B. Moonsammy
Theses and Dissertations
This study investigates the sustainability risks posed by Guyana’s rapidly expanding oil sector, with particular focus on balancing economic benefits against environmental vulnerabilities. The primary aim is to develop a Sustainability Risk Index (SRI) that captures the multidimensional impacts of offshore oil development using an integrated data-driven framework. Specifically, this thesis examines how emissions, biodiversity loss, oil spill exposure, economic volatility, and social development indicators interact to influence sustainability outcomes in the context of Guyana’s transition into a major petroleum-producing nation. The research does not involve human participants; instead, it draws on publicly available datasets collected from 2015 to 2024. …
“Makings Of A Teenage Revolutionary”: An Analysis Of Power Through The Lenses Of Gender And Institution Within The Universes Of Frank Herbert’S Dune And Suzanne Collins’ The Hunger Games, Ayah Cruzado
Theses and Dissertations
It is my objective within this paper to lead us through an in depth analysis of both Katniss Everdeen and Paul Atriedes, investigating every feature of their lives especially in the ways that they compare and differ to one another, after all, it is their written depth and complexity that makes them and their novels so fascinating to the public and earning them fame. Through my exploration, I hope to shed some light on the ways these three elements work and coincide with one another within both narratives. To separate them from one another and simply examine them as independent …
Associations Between Psychoeducation And Measures Of Treatment Engagement In Trauma-Focused Cognitive Behavioral Therapy, Shari Lieblich
Associations Between Psychoeducation And Measures Of Treatment Engagement In Trauma-Focused Cognitive Behavioral Therapy, Shari Lieblich
Theses and Dissertations
Despite the efficacy of TF-CBT, its effectiveness is compromised by high premature dropout or attrition rates. Psychoeducation, the first component of TF-CBT, provides both a rationale for engagement in treatment and normalizes symptoms to instill hope in youth and their caregivers. This component has been minimally examined as a predictor of later-phase symptom outcomes, mostly in adult trauma treatments, with mixed results. The goal of the current study is examine the influence of psychoeducation on participation-related variables in TF-CBT. Results indicate a positive association between the percentage of sessions of with psychoeducation and attrition and negative association with percentage session …
The Relationship Between Psychotherapist Self-Disclosure And Occupational And Emotional Variables, Kay Nikiforova
The Relationship Between Psychotherapist Self-Disclosure And Occupational And Emotional Variables, Kay Nikiforova
Theses and Dissertations
The effect of therapist self-disclosure practices on patients and the therapeutic relationship has long been debated. The historical trend of viewpoint toward self-disclosure began from predicting a negative, therapy-interfering stance to a growing openness towards the consideration that therapists sharing about themselves in session can have a positive effect on the patient. Evidence exists for both potential patient benefit and harm from therapists engaging in self-disclosure. Still, there is an increasing body of evidence that demonstrates that therapist self-disclosure benefits the therapeutic process, increases patient disclosure, and provides a more positive view of the therapeutic relationship. However, at present, there …
False Awakenings, Stevie Knauss
False Awakenings, Stevie Knauss
Theses and Dissertations
This paper discusses the boundary between dreams and reality, and offers some unconventional techniques for discerning the difference. It describes Knauss’s various performance rituals developed around a case study that traces the genealogy of a ringtone. This study attempts (and fails) to use cultish thinking as a means of deprogramming and poisonous distraction as a cure for attentional assault.
Area Of Effect The History And Effects Of Linguistic Choices Made In The Final Fantasy Franchise, Camille Mcdermott
Area Of Effect The History And Effects Of Linguistic Choices Made In The Final Fantasy Franchise, Camille Mcdermott
Theses and Dissertations
The Final Fantasy franchise, a seminal role-playing game (RPG) series, has captivated a global audience since its inception in 1987. This thesis, titled "Area of Effect: The History and Effects of Linguistic Choices Made in the Final Fantasy Franchise," explores the intricate use of language that has shaped the series' identity and influenced its worldwide fanbase. The linguistic landscape of Final Fantasy is as diverse and dynamic as its fantastical worlds, evolving from simple text boxes to fully voiced narratives. This study examines the historical context and evolving linguistic choices throughout the series, highlighting how these decisions enrich the gaming …
Increased Dissolution Rate And Decreased Processing Temperature For Immediate Release Fdm 3d Printed Tablet Of Weakly Acidic Drugs By Acid-Base Supersolubilization, Mohammed Irfan Syed
Increased Dissolution Rate And Decreased Processing Temperature For Immediate Release Fdm 3d Printed Tablet Of Weakly Acidic Drugs By Acid-Base Supersolubilization, Mohammed Irfan Syed
Theses and Dissertations
In recent years, there has been much interest in three-dimensional (3D) printing for the development of personalized and on-demand medications for better therapy. In 3D-printing, materials are deposited layer by layer to form tablets and pellets. Among various 3D-printing technologies, the fused deposition modeling (FDM) 3D printing, where melt-extruded filaments of drug-polymer mixtures are used for 3D printing, is most promising. However, the FDM 3D-printing often produces slow-release tablets that are not suitable for rapid drug action in the body. The present investigation was undertaken to demonstrate how rapidly dissolving 3D-printed tablets of poorly water-soluble acidic drugs could be developed …
Synthesis And Sar Of Parp Inhibitory Quinoxalin-2(1h)-One Derivatives Carrying Potency- And Selectivity-Driving Adenine-Binding Motifs, Ugochi Ann Adiele
Synthesis And Sar Of Parp Inhibitory Quinoxalin-2(1h)-One Derivatives Carrying Potency- And Selectivity-Driving Adenine-Binding Motifs, Ugochi Ann Adiele
Theses and Dissertations
Poly (ADP-ribose) polymerase (PARP) is a superfamily of proteins comprising 17 members, with PARP1 and PARP2 most notable for their implications in different types of cancer. PARP inhibitors represent an intriguing class of anticancer agents that have garnered increasing interest over the past decade due to their demonstrated clinical efficacy. AZD-9574 is one of these promising PARP1 selective inhibitors with good blood-brain barrier permeability that is currently in clinical trials for the treatment of solid malignancies and previous research attributed its selectivity and efficacy to the presence of a piperazine ring linker in its structure. However, a structure-activity relationship conducted …
Developing Stiripentol Analogs As Potential Ldh Inhibitors For The Treatment Of Glioblastoma, Anshika Y. Jain
Developing Stiripentol Analogs As Potential Ldh Inhibitors For The Treatment Of Glioblastoma, Anshika Y. Jain
Theses and Dissertations
Glioblastoma multiforme (GBM) is a highly proliferative brain tumor that has a 5-year survival rate of ~7 %. Temozolomide (TMZ) is the current standard of care therapeutic for GBM. However, 50% of patients develop resistance to TMZ. Therefore, further investigation for new GBM therapeutics is necessary to overcome this issue of drug resistance. GBM patients are known to overexpress lactate dehydrogenase (LDH), which is inversely correlated with their survival. This key glycolytic enzyme catalyzes the interconversion of pyruvate and lactate and plays an important role in cancer proliferation and invasion. Therefore, we aimed to inhibit LDH for developing therapeutics for …
The Medea Effect: The Binary Terror Of Women Existing In The Liminal Space, M. Nance
The Medea Effect: The Binary Terror Of Women Existing In The Liminal Space, M. Nance
Theses and Dissertations
The purpose of this study is to analyze the Medea character as a liminal figure. Taking a metaphorical approach to Victor Turner’s ideas on liminality, this study will deconstruct different binary oppositions—villain/victim, agent/object, Dionysian/Apollonian. The Medea character does not fall neatly to one side of these binary oppositions; therefore, this thesis argues that Medea instead inhabits the space between the binary oppositions in the realm of the liminal. The thesis then analyzes the same binary oppositions within a survey of theatrical and non-theatrical texts that feature characters that embody archetypes that originated within the Medea character—the she-devil, the murderous mother, …
Lady Macbeth's Maternity And Morality, Lauren Johnson
Lady Macbeth's Maternity And Morality, Lauren Johnson
Theses and Dissertations
This thesis explores the ways in which adaptations of Lady Macbeth from the seventeenth century to modern day have functioned to vilify or redeem Lady Macbeth based on her connection with her maternity as well as on the contextual, cultural, and political opinions surrounding both a woman’s place in society and the importance of maternity. This thesis examines William D’Avenant’s 1674 stage adaptation of Macbeth, Han Tae-Sook’s 1998 stage adaptation Lady Macbeth, and Lisa Klein’s 2009 novel adaptation Lady Macbeth’s Daughter to capture a range of cultures and the evolution of the character.
“My Pain Was Never More Valuable Than His Potential”: A Rhetorical Thematic Analysis Of Gaslighting Within Sexual Abuse Cases, Makayla Roller
“My Pain Was Never More Valuable Than His Potential”: A Rhetorical Thematic Analysis Of Gaslighting Within Sexual Abuse Cases, Makayla Roller
Theses and Dissertations
This thesis examines gaslighting within three prominent sexual abuse cases—Harvey Weinstein, Matt Lauer, and Larry Nassar—uncovered during the #MeToo movement, to better understand the rhetorical function of gaslighting. Using a combination of rhetorical thematic analysis, critical discourse analysis, a feminist lens, and a gaslighting schema, this study identifies the rhetorical tactics, gendered discourse, and power-laden discourse deployed to gaslight victims and the public. I argue that gaslighting must be examined through a rhetorical lens, as discourse is the mechanism through which gaslighting operates, shaping perceptions of truth, credibility, and power. By highlighting how language is weaponized to deny, distort, and …
"The Toughest Job You'll Ever Love": Identity Creation, Compartmentalization, And Belonging Among Queer Peace Corps Volunteers, Laura N. Keeran
"The Toughest Job You'll Ever Love": Identity Creation, Compartmentalization, And Belonging Among Queer Peace Corps Volunteers, Laura N. Keeran
Theses and Dissertations
The Peace Corps advertises that it accepts anyone, no matter their gender identity or sexual orientation; however, recruiters and staff ask volunteers to go back into the closet for their twenty-seven months of service due to the Peace Corps’ safety concerns about their volunteers being out in their host countries. Queer Peace Corps Volunteers (PCVs) answer the call to serve, accepting that it means they will need to keep their queer identities concealed for two years and three months. I conducted ethnographic interviews with ten people who have served or are currently serving in the Peace Corps and identify under …