Digital Commons Network^™

Development Of Salinomycin Analogs As Potential Anti-Cancer Agents, Pavan Goud Juluri

Theses and Dissertations

Salinomycin, a poly-ionophore antibiotic originally isolated from Streptomyces albus, exhibits antimicrobial activity against Gram-positive bacteria. Over the years Salinomycin has been studied in the effects it has on cancer, specifically cancer stem cells. Poly(ADP-ribose) polymerase (PARP) is an enzyme involved in DNA repair. Inhibiting PARP has been explored as a strategy in cancer treatment, particularly in cancers with defective DNA repair mechanisms, such as those with BRCA mutations. The benzo-thiazoles, and -imidazoles are identified as inhibitor scaffolds, which compete with nicotinamide in the binding pocket of human poly- and mono-ADP-ribosylating enzymes. Benzothiazole, and benzimidazole based compounds particularly with modification at …

Investigation Of The Phase Space Of Tungsten Oxides Nanostructures Via Resistive Hot Wire Oxidation For Efficient Electrochemical Energy Storage And Conversion Applications., Krishna Kc

Theses and Dissertations

The synthesis of tungsten oxide (WO3−δ, 0 ≤ δ ≤ 1) nanostructures with controlled phase and morphology remains a significant challenge, particularly for applications in energy conversion and storage. This dissertation presents an eco-friendly and time-efficient method for synthesizing tungsten oxide nanostructures with tailored stoichiometry and crystal phases through the Resistive Hot Wire Oxidation (RHWO) technique. In this method, a tungsten wire is heated via resistive heating in an oxygen environment, and by precisely controlling the growth conditions, we successfully synthesized WO2.72, WO2.76, WO2.80, WO2.83, WO2.90, and WO2.98 phases with controlled morphologies using simple instrumentation. This approach eliminates the need …

Assessing Abuse And Neglect In U.S. Nursing Homes: A Comparative Analysis Across Pre-, During, And Post-Pandemic Periods, Katherine Gane

Theses and Dissertations

Nursing homes are among the most closely regulated providers in the U.S. healthcare system, with both federal and state agencies working together to monitor care and help protect residents. The COVID-19 pandemic, however, introduced unprecedented challenges for facilities and survey agencies alike, disrupting normal operations, limiting in-person visits, and temporarily shifting regulatory priorities. The purpose of this study was to examine how these pandemic-related disruptions were reflected in the severity and reporting patterns of substantiated abuse and neglect deficiencies in U.S. nursing homes. Using publicly available data from the Centers for Medicare & Medicaid Services (CMS), this study analyzed 39,607 …

A Little Blue Hedgehog That Runs A Lot And Has An Attitude: An Analysis Of The Covers Of Archie Comics’ Sonic The Hedgehog, Eleanor Herman

Theses and Dissertations

Through the lens of Robin Williams principles of design as outlined in her book, The Non-Designer’s Design Book, this thesis analyzes selected covers of Archie Comics’ Sonic the Hedgehog comic book series to see how the covers evolved over time, as the nearly 25-year continuous run allows for a unique analysis opportunity. 18 issues were selected and analyzed, with conclusions drawn from the covers’ use of contrast, alignment, repetition, and proximity.

Developing A Multimodal Approach To Channel Characterization On Youtube, Shadi Shajari

Theses and Dissertations

YouTube has become a dominant arena for global information sharing, where creators and audiences interact through content, comments, and engagement dynamics. Understanding how these interactions shape a channel’s identity requires a comprehensive characterization of both audience behavior and content structure. This dissertation develops a unified framework for characterizing YouTube channels through multimodal analysis that integrates behavioral modeling, dimensionality reduction, clustering, and content-based characterization to provide a holistic view of audience and editorial patterns. The framework begins by analyzing the structural relationships within co-commenter networks, where users who repeatedly comment on the same videos are connected to capture patterns of interaction …

Improving Surface Analysis Through The Correct Use Of Low Energy Ion Scattering And X-Ray Photoelectron Spectroscopy: Best Practices, Common Errors, And Multimodal Approaches For Material Development, Joshua W. Pinder

Theses and Dissertations

Surface analysis is the study of the atoms at surfaces and their connectivity, including their relative depth distribution, concentration, chemical state, and crystallinity. These characteristics govern many important material properties. X-ray photoelectron spectroscopy (XPS) is one of the most widely used surface analysis techniques. Proper interpretation of XPS spectra including the appropriate use of backgrounds, peak shapes, peak positions, and charge compensation, with appropriate constraints on fitting parameters provide valuable information about elemental composition, concentration, depth distribution, and chemical speciation of surface atoms. However, despite widespread use, much of the XPS literature contains poor interpretations and irreproducible results which undermine …

Defining And Evaluating Performative Activism: A Mixed Methods Approach, Caitlyn Renee Upton Massaro

Theses and Dissertations

Activism, specifically Performative Activism (PA), has been difficult to study due to its wide variation and individual complexity. Study 1, a qualitative exploration of PA, involved interviews with 9 individuals, who were highly variable on the ADDRESSING Framework, regarding their experiences with and opinions on PA. Study 1 used Reflexive Thematic Analysis to identify 6 behavioral markers of PA which were used to create a definition of Performative Activism based on the voices and opinions of diverse people in activist spaces. Study 2 was an ABA (test-retest) design using fictional scenarios to train participants to identify PA. Participants were 54 …

Topological Data Analysis Of New York City Taxi Trip Data Using Advanced Dimensionality Reduction And Clustering Techniques – Uncovering Structure And Timeliness, Mahalakshmi Sakthivel

Theses and Dissertations

In this project, we used Topological Data Analysis (TDA) to explore the shape and structure of high-dimensional data and the timeliness dimension of information quality through topological data analysis, with the long-term goal of automatically computing timeliness values that reflect how useful data items are for decision making. The project followed a two-phase approach: in the first half, we employed the Kepler Mapper library along with techniques like Principal Component Analysis (PCA), Uniform Manifold Approximation and Projection (UMAP), T-SNE (t-Distributed Stochastic Neighbor Embedding) and Customized Embedding to analyze and visualize complex datasets. In the second phase, we specifically applied our …

Implementation Of The Framework For Great Schools: Lessons From New York City, Jay M. Langkamp

Theses and Dissertations

This dissertation explores the implementation of the Framework for Great Schools in the New York City Department of Education from 2015 through 2019. The study addresses a gap in the literature, specifically regarding NYC School Survey data and the relationship between it, school context, and student outcomes, at a time when families and district leaders regularly use publicly available school-level data to inform their decision-making, understanding how frameworks such as the Framework for Great Schools is essential. The Framework focuses on six elements: Rigorous Instruction, Supportive Environment, Collaborative Teachers, Effective School Leadership, Strong Family and Community Ties, and Trust. It …

Implementing Person-Centered Planning In Stem To Enhance Self-Determination And Self-Advocacy For Transitioning High School Students With Disabilities, Lynda Shanahan

Theses and Dissertations

This dissertation investigated person-centered planning as an evidence-based approach for high school students with disabilities. The primary objective of this research was first to determine the impact of person-centered planning on the development of self-advocacy and self-determination skills among high-functioning students with disabilities embedded in a special education STEM curriculum, and to explore students' perceptions of transition services. To address this objective, the study employed a Mixed-Methods Action Research Design, consisting of focus group interviews with 11th- and 12th-grade high school students with disabilities. This study drew on a transformative theoretical framework grounded in quality-of-life and communities-of-practice theories. Key findings …

Densest Subgraph Discovery On The Cpu, Hunter Gerard Gareau

Theses and Dissertations

The Densest Subgraph Discovery (DSD) problem is a prevalent problem in the field of graph mining, aiming to find the cohesive subgraph. Given a graph �� = (��,��) and an integer �� ≥ 2, the goal is to find a vertex sub- set �� ⊆ �� whose induced subgraph �� (��) maximizes the ��-clique density, defined as the number of ��-cliques per vertex. Larger val- ues of �� capture higher-order connectivity patterns beyond edges, enabling the discovery of more cohesive structures. There have been many solutions to this problem. However, one avenue that other graph mining problems have gone down …

Acoustic Analysis Of Prosodic Speech Pause In Autistic And Neurotypical Adults, Rachel Johnson

Theses and Dissertations

The purpose of this study is to examine prosodic speech pause across two groups: neurotypical and autistic young adults. Conversational speech samples were collected from 11 neurotypical and 11 autistic young adults between the ages of 18 and 26. Speech samples were subsequently transcribed and analyzed using Praat Software. The boundaries of between- and within-utterance pauses were identified, as well as acoustically determining if the pause was filled, silent, or a combination of both. Results found a significant difference in the frequency of pauses as a function of location, pause type, and neurological status. As expected, combination pauses were the …

Perception Of Prosodic Speech Patterns Of Autistic Individuals, Rebecca Lunt

Theses and Dissertations

The purpose of this study was to determine the perception that neurotypical individuals have of autistic individuals’ speech, including their speech prosody. Speech samples were collected from four neurotypical and four autistic young adults as they answered interview questions. Then, 50 neurotypical listeners (28 female, 22 male) were recruited to listen to the speech samples and rate the speech on visual analogy scales on their likeability and ability to communicate. Participants were told prior to listening to the speech samples whether or not the speaker had autism; however, there were both deceptive and truthful listening conditions, with some autistic speakers …

Infinite Line, Infinite Knowledge: The 'Spera' And Organized Chaos In Lambert's Encyclopedia, The 'Liber Floridus', Ava Romano

Theses and Dissertations

The Liber Floridus is a medieval encyclopedia renowned for its program of circular diagrams, or sperae. Inside this manuscript of 190 chapters, these diagrams frame and embody written knowledge, revealing a connection between encyclopedism and life in the Benedictine monastery by creating a coherent visual organization of chapters.

Following The Thread: Maria Lai’S 1981 Legarsi Alla Montagna, Claire Borre

Theses and Dissertations

This thesis examines Maria Lai’s (1919-2013) Legarsi alla montagna (1981), a three-day, relational project in which seventeen miles of ribbon were wound through the Sardinian town of Ulassai. In its conception, execution, and legacy, Lai’s project represented a significant challenge to traditional monumentality.

Airbnb And The End Of The Local, Nadia Beyersdorf

Theses and Dissertations

This thesis examines how second-home ownership and self-catered tourism reshape community life in Tenby, Wales. While gentrification research often focuses on permanent displacement, less attention has been given to the movement of temporary residents that erodes local culture, social ties, and transforms everyday relationships in coastal towns.

Negotiating Sacred Space: Monastic Endurance And The Spatial Politics Of Sistematizare In 1980s Bucharest, Symantha G. Byrd

Theses and Dissertations

Under Ceaușescu's 1980s Sistematizare program, Bucharest's Orthodox monasteries sustained sacred life through "negotiated resilience": ritual repetition and spatial adaptation under surveillance and constrained visibility. Văcărești, Mihai Vodă, and Antim map a spectrum—erasure, relocation/concealment, and institutional negotiation—complicating binaries of resistance and collaboration.

Retroactive Eligibility Waivers: Innovative Or Ineffective?, Mohamed Kacem Benyamine

Theses and Dissertations

Medicaid’s retroactive eligibility provision covers medical expenses for beneficiaries up to 90 days before the application date. Retroactive eligibility insulates uninsured, low-income households from expensive healthcare emergencies. New Hampshire, Arkansas, and Iowa recently obtained waivers to end retroactive coverage. Using a difference-in-differences design and data from the Behavioral Risk Factor Surveillance System, I evaluate whether changes in retroactive coverage affect enrollment rates and self-reported health. Removing retroactive eligibility has no statistically significant effects on insurance enrollment or self-reported health. However, it does increase rates of access to a doctor by 1.0% overall and by 1.6% for women. Removing retroactive eligibility …

Fugitive Formalisms: Strategies Of Dissemblance And Dissent In The Work Of Queer-Identifying Artists, 1970–Present, Rowan Diaz-Toth

Theses and Dissertations

Utilizing case studies of works by Hélio Oiticica, Scott Burton, and Felix Gonzalez-Torres as points of departure, this thesis puts forth a speculative historical framework for reconsidering queer art practices up through the present day in opposition to regimes of visibility and transparency, exploring the subversive, fugitive potential of non-representational formalisms.

The Role Of Exotic Plants In The Diet Of Black-And-White Colobus Monkeys (Colobus Guereza) In Kibale National Park, Uganda, Michelle Gaykov

Theses and Dissertations

Exotic plants have both positive and negative impacts on their environment. They may act as additional food sources for the local fauna or as competition for local flora or leading to changes within a landscape or ecosystem. To considere the role of exotics in primate diet, this study focused on the dietary role of exotic plant species in the diet of a leaf-eating foregut fermenting monkey, the black-and-white colobus monkeys (Colobus guereza) in Kibale National Park, Uganda. Int this study, I followed individuals in two groups of black-and-white colobus monkeys for 21 days recording their food intake (0700-1900). I also …

Simulation Of Quantum Walks For Secure Data Access Patterns, Arslan Ahmad Janjua

Theses and Dissertations

Quantum computing is revolutionizing computational science, offering fundamentally new approaches to information processing that surpass classical limitations. One of the most versatile and powerful tools in this emerging field is quantum walks. Quantum walks are quantum analogs of classical random walks that leverage superposition and interference to explore complex spaces efficiently.

This thesis will explore how discrete-time scattering quantum walks can be simulated and analyzed to investigate patterns of secure data access. By modeling quantum walks on a variety of graph structures and studying the dynamics of marked vertices, the project aims to demonstrate how quantum interference and graph topology …

The Decadent Bible: Biblical Intertextuality In Flaubert’S Herodias And Wilde’S Salome, Shoshana Mintz

Theses and Dissertations

This paper argues that Gustave Flaubert’s Hérodias and Oscar Wilde’s Salomé incorporate biblical intertextuality throughout their work as a means to showcase Decadent technique and themes. Both authors weave direct quotations from biblical sources such as the Gospels of Matthew and Mark, Isaiah, Ezekiel, Revelation, and Acts into their texts, layering biblical passages with themes of excess, eroticism, and decay central to the Decadent movement. Drawing on Julia Kristeva’s theory of intertextuality, I show how these biblical fragments intersect with narrative voice to destabilize meaning and form a unique, new work of writing that intertwines their own words with biblical …

O Esqueleto De Um Romance, Lanna Leite

Theses and Dissertations

In O Esqueleto de um Romance: The Film (2025), a Berlin legal dispute between a mayor and evangelicals sparks filmmaker Lanna Leite’s reflection on faith, memory, and belief. Using archival, 16mm, and 8mm footage, the experimental film frames filmmaking as an ephemeral, performative practice resisting closure and conventional narrative finality.

Qualitative Exploration Of Hallucinations Among Adolescents With Suicide Ideation And/Or Attempts, Rebecca E. Lewis

Theses and Dissertations

A qualitative study exploring and characterizing how psychotic experiences (PEs), specifically hallucinations, may affect suicidal behaviors in adolescents. Thematic analysis revealed eight key themes within the connection, capturing unique perspectives and nuanced meanings. Exploring this intersection may increase the understanding of adolescent PEs and help inform more targeted interventions.

Structural Characterization Of Peptide Nanoaggregates At Varying Concentrations And Their Impact On Cellular Responses, Malika Rozmetova

Theses and Dissertations

Peptide nano-assemblies can regulate cellular pathways in a structure-dependent manner. Here, we show that the enzyme-responsive peptide NapFFK(NBD)Yp forms distinct nanoscale assemblies at different concentrations, triggering differential ER stress and extracellular vesicle release in MDA-MB231 cells. These results highlight the importance of supramolecular organization in peptide–cell interactions.

One Stone's Journey, Satoko Saito

Theses and Dissertations

One Stone’s Journey is a participatory, experiential thirty-minute documentary about uranium. By using an embroidered world map and appealing to participants’ senses—especially touch—the project explores the possibility of telling the story of radiation, which is invisible, intangible, and silent. Uranium is a radioactive material used by the United States in the development and production of the atomic bombs during the Manhattan Project. This year, 2025, marks the 80th anniversary of the atomic bombings of Hiroshima and Nagasaki. The Fukushima Daiichi nuclear power plant accident in 2011 was on a scale comparable to the Chernobyl disaster of 1986, and the threat …

"The Very Milk And Sperm Of Kindness": Democratic Pleasures And Echoes Of Intimacy In Moby-Dick And Absalom, Absalom!, Nicholas Profeta

Theses and Dissertations

This paper examines homosocial relationships in Moby-Dick and Absalom, Absalom! to evaluate the ways male bonds have transformed between the nineteenth and twentieth centuries, and how these relationships comment on the strength and possibilities of American democracy. I argue that Melville’s novel presents a utopian vision of America defined by democratic bonds developed through labor and homoerotic intimacy that cut across racial lines and melt individual identities, while Faulkner’s novel reflects many of those imagined possibilities, only to see them wither away under the weight of racial divisions. Ishmael and the crew of the Pequod embrace this erasing of self, …

"Catching Up": Christian Walker's Critical Lens, Noam Parness

Theses and Dissertations

“Catching Up” examines three bodies of photographic work that artist, critic, and curator Christian Walker (1953-2003) generated between 1984-1991. By reading each series against a corresponding text, “Catching Up” furthers an understanding of how Walker’s works reconstruct experiences and histories of race and sexuality in the United States.

The Effect Of Extending In-State Tuition For Undocumented Students On College Enrollment And Tuition Pricing, Dongxin Weng

Theses and Dissertations

I use panel data of public institutions from the Integrated Postsecondary Education Data System, and estimate the effect of in-state tuition policy using a staggered difference-in-differences estimator. The results reveal that most of the policy's effect is concentrated among Hispanic students, while other student groups and tuition are mostly unaffected.

The Effect Of Medical Aid In Dying On Health Outcomes And Risky Behavior Of The Elderly, Jacky Wu

Theses and Dissertations

This study examines the effects of Medical Aid in Dying (MAiD) legalization on health outcomes and behavior among elderly U.S. adults using BRFSS data from 2005-2022. Using staggered difference-in-differences, this paper finds that MAiD increases exercise, lowers BMI, and reduces blood pressure medication use.