Mechanical Characterization And Modeling Of Rat Myocardia Under The Influence Of Epirubicin, Abdallah Mahmoud Alkhaiyat

Theses and Dissertations

Cancer remains a predominant health challenge that is responsible for a significant portion of global morbidity and mortality. Epirubicin (EPI), a chemotherapeutic anti-cancer drug, has shown remarkable efficacy in combating various malignancies. However, it is known to have undesirable side effects on the heart, collectively referred to as cardiotoxicity. This research investigates the adverse effects of chemotherapy on cardiac contractility through an in vitro examination of the mechanics of healthy and infarcted animal heart tissues. Electrically stimulated slices of rat ventricular tissue were tested using an isometric force measurement tissue bath. The tissue slices were subjected to uniaxial stretching, allowing …

Resilience By Design: A Multi-Metric Assessment Of Urban Vulnerability Across Human-Centric, Built, And Climatic Environment Dimensions, Karim Abdelhady

Theses and Dissertations

Urban resilience and sustainability have emerged as fundamental imperatives in contemporary urban planning, as cities face mounting pressures from climate change, population growth, and increasing socio-economic disparities. Resilient urban systems are not only those that withstand shocks, but also those that ensure the long-term well-being, equity, and functionality of their environments. As such, advancing the capacity to systematically evaluate resilience across spatial and temporal scales is critical to informing adaptive, forward-looking planning strategies. Despite a growing body of research on urban resilience, prevailing approaches remain limited in scope and resolution. Many studies tend to examine resilience through isolated lenses—focusing either …

An Impact Assessment Of The Effectiveness Of Utilizing Informal Health Communication Interventions To Spread Health Recommendations And Change Public Perception, Lina Mohamed Ezzat Ahmed Abdel Mawgoud

Theses and Dissertations

Brain health is an increasingly urgent but critically under-addressed public health priority in Egypt and the wider MENA region. Despite its centrality to aging, productivity, and overall quality of life, public understanding of brain health remains limited, and stigma continues to shape responses to dementia and cognitive decline. This study evaluates the effectiveness of informal, culturally adapted health communication as a tool to shift perception, increase awareness, and promote behavior change among non-medically trained adults in Egypt.

Grounded in global evidence on cognitive reserve, neuroplasticity, and the life-course approach to brain health, the intervention translated expert-informed brain health recommendations into …

Electronic Transport In Twisted Bilayer Tungsten Diselenides, Walid Zaher

Theses and Dissertations

This thesis investigates density waves (DWs) in twisted bilayer tungsten diselenide (tWSe₂) using a mean field approximation, with a focus on electron-electron interactions, and the system’s free energy at zero temperature. For the mean field approximation, the study initially employed same-spin nesting vectors, which were found insufficient to induce DWs formation. In contrast, when opposite-spin nesting vectors were used, DWs emerged, indicating that these vectors can support DWs formation. The plots were produced under perfect nesting conditions, where van Hove singularities (VHS) occur. At zero temperature, perfect nesting provides a complete picture of the upper limit of DWs formation, as …

Irrigation Efficiency In Green Wall Systems Utilizing Iot: Developing And Testing A Method To Optimize Water Use For Green Walls, Yomna Zaghloul

Theses and Dissertations

This study investigates the application of an Internet of Things (IoT)-based automated irrigation system for green walls in Cairo, Egypt, assessing its impact on water conservation, energy consumption, and plant health across a three-month experimental period. The research compared a sensor-controlled drip irrigation system utilizing the ESP8266 microcontroller and real-time environmental monitoring against conventional timer-based irrigation methods. Water usage data revealed that the IoT system consistently achieved substantial savings—averaging nearly 60% less water consumption than the control group—without compromising overall plant vitality. Energy efficiency was also improved, with automated cycles reducing pump operating time by more than 50%. Plant growth …

A Virtual-Reality-Based Dental Simulator For Endodontics With Automated Formative Feedback, Yousef Salah Abo El Ela

Theses and Dissertations

Advancements in virtual reality (VR) and haptic technology are transforming the landscape of medical and dental education, offering new avenues for safe, immersive, and repeatable training experiences. Within dentistry, endodontics presents unique challenges for preclinical education due to anatomical complexity, limited access to extracted teeth, ethical concerns, and the shortcomings of conventional plastic models. Despite endodontics specific plastic teeth being available, they fall short of replicating the hardness of real extracted teeth, are relatively costly compared to generic plastic teeth, and are ultimately a disposable item which makes them inadequate as a sustainable long-term solution. Extracted teeth do a much …

Towards Decarbonizing Concrete Industry In Egypt: Material Alternatives, And Economic Viability, Reem Gamal

Theses and Dissertations

The construction industry remains one of the largest contributors to global greenhouse gas emissions, with cement and steel production accounting for approximately 15% of total emissions. As global infrastructure demands continue to rise, there is an increasing need for practical tools that support low-carbon construction practices in line with international climate commitments. This research presents the development and testing of a mathematical, adaptable decision support system designed to assess both the environmental and financial impacts of material selection in concrete production. Focusing on life cycle stages A1 to A3, raw material extraction, transportation, and manufacturing, the decision support system enables …

A Computational Study Of The Chemomechanics Of Paracetamol Polymorphs: Towards Improving Drug Tabletability, Karim Nader Samra

Theses and Dissertations

The mechanical properties of pharmaceutical crystals are of great importance in tablet manufacturing. Also, knowing the mechanical properties of different polymorphs of the same crystal can reduce the overall production cost. In this study, computational work was done via performing density functional theory calculations on 3 paracetamol crystal polymorphs Form I, II, and III. Understanding the chemical bonding helps in predicting the key elastic properties for different crystallographic directions. In Form II, lattice vector C is dominated with the intermolecular hydrogen bond OH…O giving it the stiffest Young Modulus and the least Poisson’s ratio. Then comes the A-Axis which contains …

Digital Payment Adoption And Firm Performance In Egypt: An Empirical Study From The Digital Transformation Era In Mena, Alhussein M. Mowafi

Theses and Dissertations

This study investigates the relationship between digital payment adoption and firm-level innovation and revenue performance in Egypt, using microdata from the Survey of Enterprise Digitization published by the Economic Research Forum (ERF). Digital transformation, specifically payments, has accelerated across emerging economies, yet empirical evidence on its firm-level impacts in the Middle East and North Africa (MENA) remains limited. The study is framed through the Technology-Environment-Organization (TOE) framework and is highly incorporated with the Solow Growth Model through indirect technological growth inputs in the Solow residual. To address this gap, the study employs probit and ordered logit models to examine whether …

Investigating The Risk Factors Affecting The Control Of Diabetes And Hypertension In The Refugees Living In Egypt, Noura Seada

Theses and Dissertations

Introduction: Non-Communicable Diseases (NCDs) account for 74% of global deaths, with high prevalence of Diabetes and Hypertension worldwide. Egypt hosts over 1 million registered refugees and asylum seekers, often lacking inclusion in social protection or insurance schemes. This study aimed to assess the factors affecting the control of Type 2 Diabetes (T2D) and Hypertension (HTN) among Syrian and Sudanese refugees in Egypt, focusing on healthcare access, sociodemographic characteristics, lifestyle, and health behaviours.

Methods: This study employed a cross-sectional design using a self-administered questionnaire and BMI measurement. Data were collected from 246 refugees diagnosed with type T2D and/or HTN in the …

The Effect Of The Socioeconomic Variety In Greater Cairo On Transport Mode Choices, Rafik Yanni

Theses and Dissertations

In the last decade, Egypt has experienced a noticeable upgrade in its infrastructure investment, implementing a lot of transport projects, especially in the Greater Cairo region. In a city with over 20 million residents, variations lie in socioeconomic elements like income, age, gender, and neighborhood, which shape people’s choice of mobility modes based on their culture and lifestyle. The questions then become: whom are these new projects targeting? What are the barriers to using these services? And is there any willingness to change commuting habits if conditions changed? This thesis investigates how the socioeconomic variety in Greater Cairo metropolitan region …

Intelligent Skies: Deep Learning Architectures For Scalable Aviation Safety Systems, Amine Khelifi

Theses and Dissertations

The growing complexity of aviation operations, particularly in rotorcraft and vertical flight necessitates the development of intelligent, automated systems to enhance safety and situational awareness. This thesis investigates the application of artificial intelligence (AI), with a focus on deep learning (DL), to address critical safety challenges in aviation. Four core use cases are examined: helicopter cockpit flight data monitoring, runway detection, helipad segmentation, and obstacle localization around rotorcraft landing zones. Each application targets a specific gap in current aviation infrastructure, with an emphasis on operational needs identified by the Federal Aviation Administration (FAA). Leveraging a range of DL architectures, including …

Metal Free Multicomponent C-C And C-N Bond Formation Via Cross – Coupling And Cross – Dehydrogenative Coupling Methodologies For The Synthesis Of Diversely Functionalized N – And O – Heterocyclic Compounds, Reicha Pandey Ms

Theses and Dissertations

Heterocyclic compound is a significant domain of organic chemistry that focuses with synthetic, design and characteristics. This molecule is characterized by ring structure including one or more atom of an elements other than carbon (C), typically nitrogen (N), Oxygen (O) or Sulphur (S). The synthesis of heterocyclic compound via sustainable strategy encompasses various approaches such as design and implementation of real time analysis aimed at pollution prevention. It demonstrates wide range of medicinal application by showing various activities such as anticancer, anti-inflammatory, anti-microbial and many more. Additionally, many functional materials including dye, polymers etc. are the other application of heterocyclic …

A Point-Cloud Data Analysis Framework For Early Deformation Detection, Avinash Pandey

Theses and Dissertations

Frost heave and thaw-related deformation threaten the performance of roads, runways, embankments, and buried utilities in cold regions, yet traditional inspections remain reactive and often miss early uplift. This study evaluates the capability of LiDAR (Light Detection and Ranging) to detect small-scale ground deformation and introduces a practical point-cloud framework designed for early-stage characterization. Controlled jack-lift experiments quantified handheld LiDAR accuracy at uplift increments of 6.35, 12.7, 19.05, and 25.4 mm, with corresponding detection accuracies of 88%, 86%, 93.33%, and 94%. Registration quality had a significant impact. The targetless scans showed slight misalignment, whereas spherical targets provided precise, repeatable outputs. …

Investigation Of The Phase Space Of Tungsten Oxides Nanostructures Via Resistive Hot Wire Oxidation For Efficient Electrochemical Energy Storage And Conversion Applications., Krishna Kc

Theses and Dissertations

The synthesis of tungsten oxide (WO3−δ, 0 ≤ δ ≤ 1) nanostructures with controlled phase and morphology remains a significant challenge, particularly for applications in energy conversion and storage. This dissertation presents an eco-friendly and time-efficient method for synthesizing tungsten oxide nanostructures with tailored stoichiometry and crystal phases through the Resistive Hot Wire Oxidation (RHWO) technique. In this method, a tungsten wire is heated via resistive heating in an oxygen environment, and by precisely controlling the growth conditions, we successfully synthesized WO2.72, WO2.76, WO2.80, WO2.83, WO2.90, and WO2.98 phases with controlled morphologies using simple instrumentation. This approach eliminates the need …

Developing A Multimodal Approach To Channel Characterization On Youtube, Shadi Shajari

Theses and Dissertations

YouTube has become a dominant arena for global information sharing, where creators and audiences interact through content, comments, and engagement dynamics. Understanding how these interactions shape a channel’s identity requires a comprehensive characterization of both audience behavior and content structure. This dissertation develops a unified framework for characterizing YouTube channels through multimodal analysis that integrates behavioral modeling, dimensionality reduction, clustering, and content-based characterization to provide a holistic view of audience and editorial patterns. The framework begins by analyzing the structural relationships within co-commenter networks, where users who repeatedly comment on the same videos are connected to capture patterns of interaction …

Topological Data Analysis Of New York City Taxi Trip Data Using Advanced Dimensionality Reduction And Clustering Techniques – Uncovering Structure And Timeliness, Mahalakshmi Sakthivel

Theses and Dissertations

In this project, we used Topological Data Analysis (TDA) to explore the shape and structure of high-dimensional data and the timeliness dimension of information quality through topological data analysis, with the long-term goal of automatically computing timeliness values that reflect how useful data items are for decision making. The project followed a two-phase approach: in the first half, we employed the Kepler Mapper library along with techniques like Principal Component Analysis (PCA), Uniform Manifold Approximation and Projection (UMAP), T-SNE (t-Distributed Stochastic Neighbor Embedding) and Customized Embedding to analyze and visualize complex datasets. In the second phase, we specifically applied our …

Implementing Person-Centered Planning In Stem To Enhance Self-Determination And Self-Advocacy For Transitioning High School Students With Disabilities, Lynda Shanahan

Theses and Dissertations

This dissertation investigated person-centered planning as an evidence-based approach for high school students with disabilities. The primary objective of this research was first to determine the impact of person-centered planning on the development of self-advocacy and self-determination skills among high-functioning students with disabilities embedded in a special education STEM curriculum, and to explore students' perceptions of transition services. To address this objective, the study employed a Mixed-Methods Action Research Design, consisting of focus group interviews with 11th- and 12th-grade high school students with disabilities. This study drew on a transformative theoretical framework grounded in quality-of-life and communities-of-practice theories. Key findings …

Comparative Evolution Of Caenorhabditis Hermaphrodites, James Francis Kennedy

Theses and Dissertations

The Caenorhabditis genus produced three independently-evolved hermaphroditic species, C. elegans, C. briggsae, and C. tropicalis. This convergence happened by the independent co-option of male programs for use in a female body. This required two distinct steps: (1) mutations in the sex-determination pathway that activated spermatogenesis in XX animals, and (2) mutations that expressed one of the redundant sperm activation signals in XX animals. My project focused on characterizing how sex-determination genes work in C. briggsae and C. tropicalis. Loss-of-function alleles were used to compare the core sex-determination pathway to that of C. elegans. I found that the somatic sex-determination pathway …

Negotiating Sacred Space: Monastic Endurance And The Spatial Politics Of Sistematizare In 1980s Bucharest, Symantha G. Byrd

Theses and Dissertations

Under Ceaușescu's 1980s Sistematizare program, Bucharest's Orthodox monasteries sustained sacred life through "negotiated resilience": ritual repetition and spatial adaptation under surveillance and constrained visibility. Văcărești, Mihai Vodă, and Antim map a spectrum—erasure, relocation/concealment, and institutional negotiation—complicating binaries of resistance and collaboration.

Interpreting Novel Metaphors - A Test Of The Perspective Identification View Of Metaphor Comprehension, Symmetra J. Roane

Theses and Dissertations

This study provides initial evidence for the Perspective Identification View of Metaphor. It proposes metaphor comprehension involves reliance on vehicle properties to shift the perspective of how the topic is conveyed. This is especially true when the perspective shift relies on a property the vehicle has a principled connection to.

Structural Characterization Of Peptide Nanoaggregates At Varying Concentrations And Their Impact On Cellular Responses, Malika Rozmetova

Theses and Dissertations

Peptide nano-assemblies can regulate cellular pathways in a structure-dependent manner. Here, we show that the enzyme-responsive peptide NapFFK(NBD)Yp forms distinct nanoscale assemblies at different concentrations, triggering differential ER stress and extracellular vesicle release in MDA-MB231 cells. These results highlight the importance of supramolecular organization in peptide–cell interactions.

One Stone's Journey, Satoko Saito

Theses and Dissertations

One Stone’s Journey is a participatory, experiential thirty-minute documentary about uranium. By using an embroidered world map and appealing to participants’ senses—especially touch—the project explores the possibility of telling the story of radiation, which is invisible, intangible, and silent. Uranium is a radioactive material used by the United States in the development and production of the atomic bombs during the Manhattan Project. This year, 2025, marks the 80th anniversary of the atomic bombings of Hiroshima and Nagasaki. The Fukushima Daiichi nuclear power plant accident in 2011 was on a scale comparable to the Chernobyl disaster of 1986, and the threat …

Anticancer Efficacy Of Methyl-Cantharidimide (Mca) In Liver Cancer, Yidong Li

Theses and Dissertations

Cancer is still one of the major public health challenges worldwide to the present day. Multi-drug resistance (MDR) that occurs in cancer chemotherapies is a non-negligible cause of cancer treatment failure and tumor recurrence. Overexpression of ATP-binding cassette (ABC) transporters is one of the most frequent mechanisms of MDR occurrence. Therefore, the establishment of a chemotherapy agent whose anticancer efficacy would not be affected by the overexpression of ABC transporters is in demand. Methyl-cantharidimide (MCA), a cantharidin (CTD) analog, has been approved in China for clinical liver cancer treatment. This study revealed that MCA was efficacious in the ABCB1-, ABCG2-mediated …

Mass Tourism And Sustainability Discourses: A Rhetorical Analysis Of Stakeholder Communication Across The Canary Islands, Iceland, And Puerto Rico, Carmen Collins

Theses and Dissertations

This study analyzes 123 websites from the Canary Islands, Iceland, and Puerto Rico, each including an equal number of tourism businesses, environmental organizations, and governments from each region, to examine the rhetorical digital communication strategies used and the textual differences between these websites. Thematic analysis was the methodology employed in this study. Ten themes were found inductively from the data, which are: 1) economic value framing, 2) cultural identity and heritage, 3) technological mediation, 4) inspiring guilt, awe, and urgency, 5) sustainability as an instrument, 6) intergenerational responsibility, 7) global versus local contestations, 8) accessibility and inclusion, 9) transparency and …

Perception Of Adoption Of Artificial Intelligence In Beginning Teachers’ Literacy Practices, Logan Krisl

Theses and Dissertations

The use of Artificial Intelligence, commonly known as AI, is becoming a common practice in the everyday lives and workplaces of many people around the world. This is true in the realm of education and schooling as well. With rapidly advancing technology, it is important to understand how first-year teachers are entering the workforce, including their abilities and understanding of AI's impact on their teaching practices. Using teacher interviews before and after the implementation of a professional development program around the Khanmigo AI system for educators, along with observations of professional development sessions, teacher reflection sheets, artifact analysis, and observations …

Rooted In Education: Defining And Exploring Characteristics Of School Learning Gardens And Their Influence On Student Development In Urban Settings, Jason Samuel Fuller

Theses and Dissertations

This study employed an explanatory sequential mixed-methods research design, grounded in a constructionist framework, to investigate the educational significance and perceived impact of school learning gardens in urban settings. It examined the intended outcomes of various school garden models, including their contributions to academic achievement, health, community engagement, and social-emotional well-being. The study explored similarities and differences among school gardens and the perceptions of school administrators and garden facilitators regarding their value, as well as how garden design and characteristics relate to student experiences and educational goals. Quantitative data were drawn from publicly available sources, including the NYC DOE’s Sustainability …

The Effects Of Youth Extracurricular Involvement On The Home Environment Of Millennial African American Families, Joyce Merius Speed

Theses and Dissertations

This phenomenological qualitative study explored how youth extracurricular involvement shapes the home environments of Millennial African American families. Guided primarily by Ecological Systems Theory, with Critical Race Theory as a complementary lens, the study examined how parents navigated interconnected systems of home, school, peers, and community while responding to racialized barriers embedded in youth programs. Data were collected through semi-structured interviews, observations, and document analysis with six African American mothers. Seven themes emerged: extracurricular activities, family dynamics, parental involvement, academic achievement, social development, cultural identity, and time management. Findings showed that extracurricular participation strengthened family communication, routines, and cohesion; supported …

The Impact Of School Type, Community, And School Factors On Sixth-Grade Students In New York, John Trotta

Theses and Dissertations

Throughout New York State, sixth-grade learners are taught in a wide variety of schools with various configurations in diverse communities. The institutional and environmental differences may impact students' learning as they navigate a complex transition year. This non-experimental ex post facto study examined whether school type, community, and school factors were associated with the academic proficiency of sixth-graders in English Language Arts and Mathematics in New York State. In addition, the study identified the strongest predictors of high school graduation rates. The theoretical lens of Erikson’s psychosocial theory and Bronfenbrenner’s ecological systems theory was used. This study included 1,112 public …

Commercial Off-The-Shelf Electronic Warfare Threats To Global Positioning System Receivers, Matthew P. Robinson

Theses and Dissertations

This research evaluates the feasibility of commercial-off-the-shelf (COTS) hardware developed into an electronic warfare (EW) system used to degrade or deny Global Positioning System (GPS) receivers. All 16 critical infrastructure sectors rely on GPS signals to operate safely and effectively. Millions of Americans rely on GPS signals and the services they provide in their daily lives, so the loss of these vital services would dramatically impact our society. Our nation’s reliance on the GPS network makes it a potential target for COTS EW threats. The ways and means to develop COTS hardware into EW systems to interfere with GPS receivers …