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In Silico Investigations Of Class Ii Trans Activator (Ciita): Its Plausible Implications In Neuroinflammation And Neurological Disorders, Kishore N

Theses and Dissertations

Inflammation plays a significant role in maintaining homeostasis. Neuroinflammation is a chronic inflammatory response in the central nervous system (CNS), leading to brain or spinal cord dysfunction. To promote mental health, it is crucial to understand the regulation of neuroinflammation. Class II transactivator (CIITA) is a master-regulator of the major histocompatibility complex II (MHCII).

Modulation of CIITA has been suggested as a promising intervention for inflammatory conditions, including neurological disorders. However, there is limited knowledge about the role of CIITA and its interactors in inflammation. This study aimed to understand the role of CIITA in neuroinflammation and neurological disorders using …

3d Bioprinting On Electrospun Nanofibrous Scaffolds To Fabricate Myocardial Patches, Muthu Parkkavi S

Theses and Dissertations

Tissue-engineered three-dimensional (3D) myocardial patches offer superior and innovative treatment strategy for myocardial infarction (MI). Among the various scaffold fabrication techniques, electrospinning and 3D bioprinting have received great attention due to their ability to recreate native cardiac tissue mimetic characteristics. Despite several advantages, electrospun nanofibers have limitations in cell delivery due to random cell seeding, while bioprinting faces challenges in creating hydrogel constructs with ideal mechanical properties capable of supporting cardiac contraction/relaxation cycle. Hence in this work, hybrid myocardial patches were developed by converging electrospinning and bioprinting techniques.

Electrospinning of PLCL:PEOz (B73, 7:3 blend of poly-L-lactide-co-ε-caprolactone (PLCL) and polyethyl oxazoline …

Effect Of Osmolytes On The Interplay Of Water Protein And Dna In Ecori Dna Recognition Using Molecular Dynamics Simulations, Aathithya D

Theses and Dissertations

EcoRI is a type II restriction endonuclease that has been widely used as a model system to study protein-DNA interaction owing to its high degree of specificity. This enzyme does not recognize even a single basepair change in its recognition sequence, (GAATTC)2, under normal conditions. However, in the presence of osmolytes, such as glycerol and DMSO, the specificity of EcoRI is slightly relaxed and recognizes sequences that differ from its cognate sequence in the first basepair position. This relaxed specificity has been attributed to the dehydration of the EcoRI-DNA which presumably results in tighter complex formation and subsequent catalysis. However, …

Impact Of Ionic Liquids On The Treatment Of Various Derivatives Of Prosopis Juliflora For Removing Toxic Pollutants From Wastewater, Karthikeyan A

Theses and Dissertations

Water resources are increasingly contaminated by toxic pollutants, particularly industrial effluents, posing significant environmental concerns. Addressing the toxicity of these pollutants, especially those released from textile industries, presents challenges due to their harmful effects on living organisms. Various treatment methods are employed to mitigate this issue, including coagulation, flocculation, membrane filtration, photocatalytic degradation, adsorption, anaerobic processes, and chemical oxidation. Among these, adsorption emerges as an effective and economical method due to its minimal secondary contamination, negligible sludge production, and the use of inexpensive agricultural and marine waste materials.

This study examines the ability of Prosopis juliflora treated with imidazolium-based ionic …

Ai Based Early Detection Of Hormonal Imbalance And Poly-Cystic Ovary Syndrome In Young Women, Reka S

Theses and Dissertations

A hormonal disorder, Poly-Cystic Ovary Syndrome (PCOS) usually affects women during the reproductive age. It is characterised by imbalances in hormones, particularly a rise in the female body's androgen level (male hormone) and enlarged ovaries with small cysts. PCOS can cause ovarian cysts, weight gain, acne, excessive hair growth, insulin resistance, and irregular menstrual cycles along with other health problems. While the exact origin of PCOS is uncertain and its symptoms are unclear, diagnosing PCOS in real-world conditions is a difficult task. Therefore, prompt and precise PCOS diagnosis is essential for efficient treatment and for averting long-term issues.

Clinicians typically …

Biogenic Calcite Precipitation For Coastal Sand Stabilization: A Synergistic Approach Using Marine Bacteria And Natural Fibers, Aparna Gs

Theses and Dissertations

Coastal erosion, driven by natural forces such as waves, tides, winds, and currents and further intensified by anthropogenic activities like urbanization, climate change, and coastal infrastructure development, poses a significant threat to shoreline stability. Conventional erosion control methods, including jetties, embankments, and artificial reefs, often face limitations in sustainability and effectiveness. In this context, microbially induced calcite precipitation (MICP) has emerged as a promising ecofriendly solution for ground stabilization.

The present study investigates the potential of an indigenous ureolytic marine bacterium, Bacillus sp. N₉, isolated from the coastal sediments of Nagapattinam, Tamil Nadu, for coastal sand stabilization. The strain was …

Bioprospecting Of Wheat Straw Pyrolysis Aqueous Phase To Combat Multi-Drug Resistant Pathogens, Srividhya K

Theses and Dissertations

Hospital-acquired infections (HAIs) significantly contribute to the emergence and spread of antimicrobial resistance (AMR), primarily through the contamination of high-touch surfaces. Current disinfectants have drawbacks like high environmental persistence, ecotoxicity, and resistance development, prompting the need for environmentally friendly alternatives.

One potential approach is pyrolysis, during which the biomass components are broken down into solid, liquid, and pyro-gas. The aqueous phase of the liquid fraction is usually discarded as waste, but it contains a variety of organic compounds that have the potential for antibacterial and antifungal activity. The present study assessed the anti-infective and anti-biofilm properties of wheat straw pyrolysis …

Design And Investigation Of Deep Eutectic Solvent-Assisted Extractive Fermentation Of Biomolecules, Ramya M

Theses and Dissertations

The increasing demand for sustainable and efficient bioprocessing techniques has prompted the development of novel separation strategies integrating bioproduction with downstream processing. Extractive fermentation has emerged as a promising process intensification to overcome product inhibition and enhance productivity by constantly removing target biomolecules from the fermentation medium. Although the extractive fermentation of acids and alcohols has been extensively studied, less attention has been focused on green solvents and their compatibility, phase-forming abilities, and reactor configurations.

Therefore, advancing extractive fermentation technology necessitates comprehensive studies on solvent systems and the development of modified bioreactor configurations to aid future optimization. Initially, 22 DESs …

Fabrication Of Protein-Based Nanomicelle Against Inflamed Synoviocytes In Rheumatoid Arthritis, Madhumithra Thangadurai

Theses and Dissertations

Rheumatoid arthritis (RA) is a chronic autoimmune disease marked by persistent synovial inflammation, progressive cartilage and bone destruction, and systemic complications. 1% of the global population are affected by RA, when their immune system targets synovial tissues, leading to joint pain, swelling, and functional disability. Standard treatments, such as disease-modifying antirheumatic drugs (DMARDs) like methotrexate (MTX), are limited by systemic toxicity and inconsistent patient responses, highlighting the need for improved therapies. This research work explores protein-glycosaminoglycan nanomicelles engineered using Zein with Chondroitin or carboxymethylated Dextran Sulfate as targeted drug delivery vehicles for RA.

MTX was encapsulated within these nanomicelles to …

Metal-Organic Frameworks And Nanostructured Materials For Environmental Applications, Arunkumar G

Theses and Dissertations

The global population and economic development are experiencing rapid growth. Concurrently, environmental challenges such as global warming, soil, water, and air pollution are also rising. Each year, approximately 700,000 tonnes of products are generated from 100,000 tonnes of commercial dyes. Following their use, these dyes are often released into water bodies.

This contamination of water and land results in the formation of mutagenic and carcinogenic substances harmful to living organisms. Therefore, it is imperative to treat industrial wastewater to enable its recycling for various applications. Parallelly, the vehicles are becoming indispensable to human life modern world's urbanization and advancement.

The …

Investigation Of Dependency Parsing Techniques For Digital Document Analysis Through Deep Learning Approach, Rekah D Ms

Theses and Dissertations

Digital document dependency parsing is a significant task in natural language processing. Dependency parsing supports verification of the grammatical correctness of a sentence besides enabling extraction of relevant documents. Inappropriate extraction of features may result in falsely parsing a document, leading to decreased accuracy. Machine learning methods have been employed to perform feature extraction. However, selecting pertinent features was never achieved which minimizes the time consumption and overhead.

Hence, novel machine learning and deep learning techniques have been designed in our work for accurate and computationally efficient digital document analytics through dependency parsing. Four different contributions have been proposed for …

Bridging Scales In Epidemic Modeling From Individuals To Networks And Ecosystems, Saiprasasd Vr

Theses and Dissertations

Epidemics have shaped the trajectory of human history, repeatedly exposing vulnerabilities in healthcare systems and influencing socio-economic dynamics on a global scale. The COVID-19 pandemic, in particular, underscored the pressing need for flexible and responsive modeling framework capable of adapting to dynamic and evolving epidemic scenarios. Motivated by these challenges, this thesis explores the development of innovative epidemic models that integrate classical mathematical modeling techniques, network-based frameworks, and modern data-driven approaches. Each chapter addresses a distinct dimension of epidemic spread, from vaccination dynamics and community coupling to ecological complexity and adaptive human behavior, culminating in a model-free paradigm suitable for …

Genomic Surveillance Of Indian Klebsiella Pneumoniae And Exploration Of Resistance Inhibitors, Abhirami Ks Ms

Theses and Dissertations

Klebsiella pneumoniae is an important ESKAPE pathogen that causes life threatening infections. The strains exhibiting multidrug-resistance (MDR) and hypervirulence are the priority pathogens for which immediate treatment and dissemination prevention strategies are required. To address this, genome profiling was performed to understand the AMR patterns, role of episomes, phages, virulence determinants and its association with sequence types.

The study includes 267 publicly available Indian K. pneumoniae genomes over a period of ten years and four sequenced isolates. Whole genome analysis revealed the widespread presence of diverse β-lactamase genes, with β-lactam resistance being predominant. Genes such as blaCTX-M-15, blaTEM-1B and blaOXA-232 …

Seating Charts, Connections, And Fostering Community, Mckenna B. Chow

Theses and Dissertations

This thesis explores how fostering stronger connections in the high school ceramics classroom can create a more inclusive and collaborative community. I regularly changed seating charts to encourage new relationships and strengthen classroom culture as part of this effort. Historically, seating charts have enforced uniformity and promoted specific behaviors. My research challenges these traditional purposes and proposes that seating arrangements can instead serve a more meaningful and enduring goal: promoting connection and ensuring that all students feel seen. I found that while seating charts can contribute to this goal, achieving genuine connection and inclusivity also requires several additional factors to …

Scent Of The South: Fragrance And Identity In The 19th Century, Sarah Donahua Peters

Theses and Dissertations

This thesis explores the role of personal fragrance as a cultural marker in the 19th-century American South, examining how scent reflected identity, status, and social norms in a region shaped by colonialism, capitalism, and religious influence. Drawing on historical sources, botanical knowledge, and public history practices, the project traces the evolution of fragrance from home-crafted perfumes to mass-marketed products, highlighting how access to scent was shaped by race, class, and gender. Central to the thesis is a public history exhibition designed for the Esse Purse Museum in Little Rock, Arkansas, which invites visitors to engage with scent as a medium …

Executive Functioning And Mental Health In Emerging Adults: Type 1 Diabetes Status As A Moderator, Hannah Margot Mcdaniel

Theses and Dissertations

Emerging adults (ages 18-26) with type 1 diabetes mellitus (T1DM) are especially vulnerable to diabetes management challenges when taking on increased disease responsibility during this critical period of development. They may experience higher cognitive and psychological demands compared to peers. The study examined whether having T1DM moderated the association between executive functioning (EF) and mental health symptoms (i.e., depression, anxiety, stress, and disordered eating) in emerging adults. Exploratory analyses investigated the associations between EF, disease management, and mental health symptoms. Participants were 35 emerging adults with T1DM and 35 healthy controls. Participants completed questionnaire measures of mental health and performance-based …

Remote Running Gait Analysis Using Smartphone Video And Monocular Pose Estimation: A Feasibility Study, Luke Vankeersbilck

Theses and Dissertations

Introduction: Running is a common form of exercise that comes with many health benefits; however, many people stop exercising because of the high injury risk. Running injury is connected with biomechanical risk factors. Yet, these risk factors often show inconsistent and conflicting results across studies, largely due to small sample sizes limiting statistical power. Low subject numbers may be partly due to the time requirements of traditional motion capture. Monocular pose estimation offers a promising alternative by using machine learning to track body landmarks from a single camera. This study evaluated the feasibility of remotely collecting running biomechanics data using …

Under The Sea And Into The Future With Darwin, Verne, & Wells: Evolutionary Ideas In Early Science Fiction Literature And Atomic Age Adaptations, Suzette K. Forston

Theses and Dissertations

In the latter half of the nineteenth century, Charles Darwin's theories challenged traditional ways of thinking about the world so dramatically that his writings inspired the formation of a new genre: science fiction. Two pioneering authors, Jules Verne and H. G. Wells drew from Darwin's writings in their classic novels, 20,000 Leagues Under the Seas (1870) and The Time Machine (1895). Though the two authors are often compared because they were both early science fiction authors, they approached Darwinian theory in different ways. Verne uses a more extrapolative approach and focusing on specific details of Darwin's texts to tell a …

Circadian Influences On Glycemic Control In 24-Hr Fasts Initiated At Different Mealtimes, Elizabeth Z. Gipson

Theses and Dissertations

This study investigated whether the timing of a 24-hour fast influences indicators of glycemic control throughout the duration of the fast or upon refeeding. Twenty-four adults who have overweight or obesity (13 female, 11 male) completed this randomized crossover study involving three 24-hour fasts initiated at either 8:00 am, 1:00 pm, or 6:00 pm followed by a 75 g oral glucose tolerance test (OGTT) which lasted 2 hours. Continuous glucose monitors (CGMs) were employed to track interstitial glucose throughout each fast and OGTT. Plasma samples for insulin, glucagon, glucagon-like peptide-1 (GLP-1), and glucose-dependent insulinotropic polypeptide (GIP) were collected at the …

Chemically Mediated Communication In Mound-Building Termites, Sree Subha Ramaswamy

Theses and Dissertations

Nest-building in social insects requires layered communication to coordinate complex, functional structures for housing, protection, storage, and homeostasis. This is especially striking in mound-building termites, which construct and repair large mounds collectively despite lacking image-forming eyes. This thesis investigates how Odontotermes obesus achieves such coordination through chemical communication embedded in soil.

Using controlled two-choice assays with manipulated soils, I separated airborne volatile signals from contact non-volatile signals by baking to remove volatiles, a mesh assay that presented volatile cues without contact, and solvent extraction with reapplication of contact cues. I quantified responses in major-only, minor-only, and mixed groups at two …

Copper Oxide Nanoparticles As Delivery Vehicles For Different Pt (Ii)-Drugs: Experimental And Theoretical Evaluation, Shahdan Abdelkareem

Theses and Dissertations

Platinum(II)-based chemotherapeutic agents such as cisplatin, oxaliplatin, and nedaplatin are mainstays in the treatment of a wide range of solid tumors, yet their clinical application is severely restricted by rapid degradation, poor bioavailability, and dose-limiting side effects. These challenges arise in part from the drugs’ susceptibility to premature hydrolysis, off-target interactions in the bloodstream, and degradation in the gastrointestinal tract, which collectively limit their ability to reach and act on tumor cells. To address these limitations, we explored the use of copper(II) oxide nanoparticles (CuO NPs) as nanocarriers for platinum(II) drugs, aiming to enhance drug stability, loading, and controlled release. …

Refugee Families: Parental Traumatic Stress And Child Outcomes A Scoping Review, Britta Sedig

Theses and Dissertations

This scoping review synthesizes recent literature (2019-2024) to explore mechanisms linking parental trauma to child mental health outcomes within refugee families. Guided by a systemic and relational focus, 20 studies were identified and analyzed, revealing five central themes: intergenerational transmission of trauma, parenting practices as mediators, parent-child dyadic attachment, family functioning and conflict, and post-migration and acculturative stress. Findings highlighted associations between parental trauma-related symptoms and refugee children's emotional and behavioral concerns. Parenting practices were frequently linked to child wellbeing, with some studies identifying risk factors like harsh discipline and emotional unavailability, and others noting protective roles of intentional caregiving. …

Transcription Fidelity In The Face Of Oxidative Damage, Eastilan Gyiwah Appiah

Theses and Dissertations

It is very important that the process of transcription is correctly carried out in the cell for the faithful expression of the genetic code. However, should mistakes happen, they can result in transcription errors which interfere with the protein-making machinery of the cell. This will result in accumulation of proteins and dysfunctional proteins that have the potential of causing diseases like Alzheimer’s. Oxidative damage caused by hydrogen peroxide is known to cause transcription errors in organisms like yeast. It is therefore important to investigate the extent to which hydrogen peroxide can damage cells.

Influence Of Diverse Forage Environments On Honey Bee Colony Health, Angus Catchot Iii

Theses and Dissertations

Honey bees are important pollinators that face a multitude of stressors in their environment such as pathogens, parasite pressure, forage availability and pesticide exposure. This study examined how the makeup of different environments and the stressors related to those environments are affecting honey bee health in Mississippi. A field experiment was conducted during the first year of the study across four distinct landscapes ranging from intensively cultivated cropland to predominantly natural forage habitats to assess the impact of landscape availability on varying honey bee colony health parameters. Locations that had cultivated crops within foraging range produced more honey and brood …

Social Validity Of Functional Analysis Variations, Rita M. Druffner

Theses and Dissertations

The functional analysis was developed to systematically identify the antecedent and consequent conditions mediating challenging behavior. Modifications to the traditional procedures have been developed to address barriers to implementation, including duration, environmental control, and safety. Much of the research surrounding functional analyses addresses effectiveness, barriers to implementation, and practitioner acceptability. However, there is a lack of research assessing caregiver social validity of functional analysis procedures. Social validity is the assessment of the goals, procedures, and outcomes of behavior analytic practice. Even though there has been advocacy for including measures of social within behavior analytic research and practice, there is limited …

Strategic Use Of Exogenous Feed Enzymes And Sodium Bisulfate To Optimize Broiler Production, Spencer Thomas Karn

Theses and Dissertations

Poultry producers must continually evaluate nutritional strategies to enhance broiler performance and sustainability. Chapter II assessed sodium bisulfate (SB) applied to litter, feed, and water across a 42-day grow-out. Applying SB to litter reduced pH, while 0.3% and 0.4% dietary SB improved feed conversion ratio (FCR). Water acidification with SB during the final week did not impair performance, supporting its use as a preharvest intervention. Chapter III evaluated phytase at 500, 1500, and 2000 FTU/kg, with or without protease, in reduced amino acid diets over 56 days. Birds fed a nutrient-adequate diet with 1500 FTU/kg phytase outperformed all reduced-amino acid …

Transforming Movement Assessment In Physical Therapy Through Subaquatic Data Collection, Kaitlyn Mcdonald

Theses and Dissertations

This study explored the interest and perceived barriers to integrating subaquatic diagnostic technologies (SDTs) into hydrotherapy among licensed physical therapists. Seventeen semi-structured interviews were conducted using a mixed-methods design, with 15 interviews included in the final analysis. Quantitative data were analyzed using chi-square tests, while qualitative responses were coded thematically. Results indicated no statistically significant relationships between SDT interest and career stage or hydrotherapy access, though qualitative data highlighted concerns about cost, limited access, and usability. Despite mixed interest in adoption, participants identified several potential benefits of SDTs, including improved treatment tailoring, increased patient buy-in, and enhanced outcome monitoring. Functional …

My Grandparents Raised Me: The Role Of Formative Individual And Family Experiences In Predicting Emerging Adult Substance Use, Attachment, And Mental Health Outcomes, Acacia Lopez

Theses and Dissertations

Individuals raised in a grandfamily, or family structure in which a grandparent raises their grandchildren, experience higher rates of adverse childhood experiences (ACEs), insecure attachment, and negative mental health outcomes during childhood. Literature on outcomes of these individuals across the lifespan is extremely limited, however, and it is unclear how formative individual and family experiences of being raised by grandparents carry into emerging adulthood (e.g., 18 to 25-years-old). Emerging adulthood is a developmental stage marked by significant instability and unpredictability that is linked with increased vulnerability to mental health concerns and substance use. It has been identified as an important …

Impact Of Overseeding Cover Crops On Dryland Soybeans In Mississippi Delta, Michael C. Pruden

Theses and Dissertations

In the Mississippi Delta, continuous dryland soybean (Glycine max L.) production practice is a selection for those that do not or cannot irrigate their crops. However, no crop rotation results in yield losses due to diseases, increased insect population, weed species pressure, nutrient leaching, and soil erosion. Incorporation of cover crops might offer potential benefits but needs further investigation. The objectives were to determine the optimum cover crop planting time (R6 and harvest) and ideal cover crop species, and evaluate their impact on dryland soybean grain yield, quality, and plant population. R6 overseeded cereal rye (Secale cereale L.) produced the …

Microbiomics Of Amazonian Fishes And Associations With Human Pathogens (Mycobacterium Ulcerans), Matthew Edwin Scott

Theses and Dissertations

The Amazon Rainforest and Guiana Shield are recognized as two of the most biodiverse ecosystems on Earth, particularly when considering macroorganisms. Relatively little attention has been paid to the microbiological diversity within rainforest ecosystems, or to the interactions among macro- and microbiological communities. To this end, I characterized the effects of habitat and host phylogenic parameters on the gut microbiome of freshwater fishes along the coast and within the Approuague River watershed in French Guiana. The results indicate a river continuum effect on the microbial composition of fishes, as well as a similar continuum pattern along the coast of French …