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Full-Text Articles in Entire DC Network
A Comparison Of The Effects Of Heat Therapy And Exercise Training On Vascular Function During Passive And Active Exercise, Taysom Erica Wallace
A Comparison Of The Effects Of Heat Therapy And Exercise Training On Vascular Function During Passive And Active Exercise, Taysom Erica Wallace
Theses and Dissertations
Recent evidence suggests that heat, a major byproduct of exercise, may be the mediator for many vascular adaptations that come from exercise. Thus, heat therapy that increases muscle temperature in a comparable way to exercise may be an advantageous alternative for enhancing cardiovascular health in individuals where treatment with exercise is either not possible or undesired. PURPOSE: Compare the effects of exercise and heat training on resistance artery function at rest and during exercise. METHODS: Thirty-five (18 female) healthy, untrained subjects completed a 6-week training program utilizing either high intensity knee extension (KE) exercise (40 min), localized heat therapy (pulsed …
Predicting Drug-Induced Liver Injury With Artificial Intelligence, Ting Li
Predicting Drug-Induced Liver Injury With Artificial Intelligence, Ting Li
Theses and Dissertations
Drug-induced liver injury (DILI) is an undesirable side effect to the liver caused by the common use of drugs, which is of great concern to the patients, physicians, the pharmaceutical industry, and government regulators. The current animal testing models do not present reliable results on the human DILI risk prediction during the preclinical phase. Therefore, there is an urgent need to find alternative methods to improve the human DILI risk prediction during the early stage of development. Utilizing the accumulated high-throughput transcriptomics profiles from L1000, we constructed an 8-layer deep neural network for human DILI prediction based on the largest …
Plastic, Pollution, Art, And The Caribbean, Celine Collazo
Plastic, Pollution, Art, And The Caribbean, Celine Collazo
Theses and Dissertations
The impact of a growing ocean pollution problem can be seen on the trash-filled shores of Caribbean beaches. Through a contextualization of the work of three artists, Tony Capellán, Radamés ‘Juni’ Figueroa, and Alejandro Durán, this paper discusses the cause and effects of such detritus, and possibilities for change.
Behavioral Patterns Of Goldfish (Carassius Auratus) Exploring A “Fish Tower”, Sasha Prasad-Shreckengast
Behavioral Patterns Of Goldfish (Carassius Auratus) Exploring A “Fish Tower”, Sasha Prasad-Shreckengast
Theses and Dissertations
Fish are held in captivity at some of the highest numbers of any taxa, but their curiosity is rarely studied. With this study, we set the groundwork to investigate the presence and nature of curiosity in goldfish (Carassius auratus) via novel free-choice exploration opportunities by creating a “fish tower."
Functional Characterization Of Arabidopsis Synaptotagmin-4 Protein Through Reverse Genetics Strategy, Zahid Jawed
Functional Characterization Of Arabidopsis Synaptotagmin-4 Protein Through Reverse Genetics Strategy, Zahid Jawed
Theses and Dissertations
Calcium ion plays a significant role in plant signal transduction pathways, including regulation of stress-induced gene expression. Sensor proteins such as proteins with calcium-binding C2 domains can perceive changes in cellular calcium level. Functional analysis of such sensor proteins will give us a better understanding of plant stress signaling. Synaptotagmins are a group of proteins containing C2 domains that are capable of binding calcium ions and regulate gene expression in response to external abiotic stress stimuli. Here, we used a reverse genetic approach to analyze the function of synaptotagmin – 4, which is one of the five identified synaptotagmin proteins …
Bayesian, Frequentist, And Information Geometry Approaches To Parametric Uncertainty Quantification Of Classical Empirical Interatomic Potentials, Yonatan Kurniawan
Bayesian, Frequentist, And Information Geometry Approaches To Parametric Uncertainty Quantification Of Classical Empirical Interatomic Potentials, Yonatan Kurniawan
Theses and Dissertations
Uncertainty quantification (UQ) is an increasingly important part of materials modeling. In this paper, we consider the problem of quantifying parametric uncertainty in classical empirical interatomic potentials (IPs). Previous work based on local sensitivity analysis using the Fisher Information has shown that IPs are sloppy, i.e., are insensitive to coordinated changes of many parameter combinations. We confirm these results and further explore the non-local statistics in the context of sloppy model analysis using both Bayesian (MCMC) and Frequentist (profile likelihood) methods. We interface these tools with the Knowledgebase of Interatomic Models (OpenKIM) and study three models based on the Lennard-Jones, …
Identifying Micrornas Panel Associated With Hepatocellular Carcinoma In Serum Of Chronic Hepatitis C Patients, Areeg Dabbish
Identifying Micrornas Panel Associated With Hepatocellular Carcinoma In Serum Of Chronic Hepatitis C Patients, Areeg Dabbish
Theses and Dissertations
Introduction: early detection of hepatocellular carcinoma (HCC) will reduce morbidity and mortality rates of this poorly diagnosed widely-spread disease. Dysregulation in microRNA (miRNAs) expression is associated with HCC progression. Objective: Is to identify a panel of differentially expressed miRNAs (DE-miRNAs) to enhance HCC early prediction in hepatitis C virus (HCV) infected patients. Methodology: Candidate miRNAs were selected using bioinformatic analysis of microarray and RNA-sequencing datasets, resulting in nine DE- miRNAs (miR-142, miR-150, miR-183, miR-199a, miR-215, miR-217, miR-224, miR-424 and miR-3607). Their expressions were validated in the serum of 44 healthy individuals, 62 non-cirrhotic HCV patients, 67 cirrhotic-HCV and 72 HCV-associated …
Advancing Cell-Free Protein Synthesis Systems For On-Demand Next-Generation Protein Therapeutics And Clinical Diagnostics, Emily Ann Long Zhao
Advancing Cell-Free Protein Synthesis Systems For On-Demand Next-Generation Protein Therapeutics And Clinical Diagnostics, Emily Ann Long Zhao
Theses and Dissertations
Recombinant proteins have many medical and industrial applications, but their use is complicated by commercial production and stability constraints. These issues are particularly challenging for recombinant proteins used in pharmaceutical therapeutics and clinical diagnostics. Expensive production and distribution limit the accessibility of therapeutics and diagnostics especially in the developing world. Additionally, clinical use of recombinant proteins face further challenges within biological systems including biological degradation and immunogenicity. To increase the accessibility of recombinant proteins, the cost and inefficiencies of protein manufacturing and distribution need to be significantly reduced. A powerful tool to aid in this endeavor is cell-free protein synthesis …
Utilizing Isothermal Titration Calorimetry For Measuring Beta-Galactosidase Activity In Liquid Dairy Products, Eliza Anne Brock
Utilizing Isothermal Titration Calorimetry For Measuring Beta-Galactosidase Activity In Liquid Dairy Products, Eliza Anne Brock
Theses and Dissertations
This research explores Isothermal Titration Calorimetry as a method for measuring beta-galactosidase activity directly and continuously in milk, sweet whey, sweet whey permeate, acid whey, and acid whey permeate. Beta-galactosidase in various concentrations was injected into each of the liquid dairy products spiked with lactose to verify if the heat rate from the enzymatic reaction could be observed. In addition, a consistent concentration of beta-galactosidase was injected into various concentrations of lactose in the products, to observe the heat rates from the enzymatic reaction. There was exothermic activity that never returned to baseline demonstrated in milk, sweet whey, and sweet …
Pushing It To The Limit: Determining Asian Elephant (Elephas Maximus) Olfactory Sensitivity And Discrimination Through A Behavioral Choice Task, Matthew S. Rudolph
Pushing It To The Limit: Determining Asian Elephant (Elephas Maximus) Olfactory Sensitivity And Discrimination Through A Behavioral Choice Task, Matthew S. Rudolph
Theses and Dissertations
Elephants have shown remarkable olfactory capabilities. Their sense of smell impacts their foraging choices, behavior, and ultimately, survival. Being able to detect a target odor can allow elephants to locate specific resources, identify threats, and find receptive conspecifics. Previous studies have shown that elephants can consistently detect target odors, but have not identified the limits of this detection. Thus, to investigate the extent of elephants’ odor detection capabilities, we tested Asian elephants in a two-step odor discrimination task. First, we investigated whether elephants could detect odors at varying levels of dilution after a training procedure, and then whether they could …
The Influence Of Comorbid Gad On Er Utilization In Urban Youth With Asthma, David A. Karpe
The Influence Of Comorbid Gad On Er Utilization In Urban Youth With Asthma, David A. Karpe
Theses and Dissertations
Current literature indicates a strong association between asthma and the early onset of comorbid generalized anxiety disorder (GAD) in minors and their primary caregivers. Studies show that asthma prevalence increases with certain demographic factors, such as ethnicity, socioeconomic status, and housing quality. Evidence also suggests that GAD influences decision-making, especially when deciding to utilize emergency room (ER) services for asthma-related concerns. This study analyzed the effect of comorbid GAD on minors with asthma and ER utilization. The data were provided by an earlier Stress & Justice Study (S&J) baseline survey, an investigation aimed at understanding the impact of parental criminal …
Restricted Microbial Presence, Activity, And Community Structuring Within Dry Valley Soils Of Antarctica, Scott Fillerup George
Restricted Microbial Presence, Activity, And Community Structuring Within Dry Valley Soils Of Antarctica, Scott Fillerup George
Theses and Dissertations
The McMurdo Dry Valley region is the largest ice-free area of Antarctica. Harsh abiotic conditions of the polar desert ecosystem, including extreme cold, aridity, and limited nutrient availability select for unique taxa. The comparatively simple terrestrial ecosystem is well-suited for investigating edaphic influences on microbial presence, activity, and community structuring. The Dry Valleys are viewed as a useful analog for Mars astrobiology investigations. However, most biotic investigations have been focused on lower elevations, where an understanding of edaphic effects on microbial communities within its generally more favorable conditions has emerged. Transiently wetted Dry Valley water tracks may be analogous to …
Not Again, Victor M. Perez Iii
Not Again, Victor M. Perez Iii
Theses and Dissertations
Victor Perez explores personal narratives involving artifice, domesticity, and patriarchal harms through paintings which use a hybrid of digital and hand applied painting.
A Dumb Mouth From Which The Teeth Have Been Pulled, Anna Sofie Jespersen
A Dumb Mouth From Which The Teeth Have Been Pulled, Anna Sofie Jespersen
Theses and Dissertations
This paper consists of a series of scenes in which various narratives with proximity to the truth plays out. within it I aim to articulate the dispersed subjectivity and forensic aspects to my work, as well looking at the perverseness in the desire for proximity to the fantasy, utilizing the self as a vehicle of desire.
Mixture Design Response Surface Methodology Analysis Of Seven Natural Bioactive Compounds To Treat Prostate Cancer, Ian Geddes Berlin
Mixture Design Response Surface Methodology Analysis Of Seven Natural Bioactive Compounds To Treat Prostate Cancer, Ian Geddes Berlin
Theses and Dissertations
Natural bioactive compounds have drawn the interest of many researchers worldwide in their effort to find novel treatments, including prostate cancer (PC) treatment which is estimated to be 13.1% of all new cancer cases in the U.S. in 2021. Many of these bioactive compounds have been identified from treatments in traditional Chinese medicine (TCM), that often have multiple bioactive compounds present. However, in vitro studies frequently focus on the compounds in isolation, or in simple combinations of two compounds. We used mixture design response surface methodology (MDRSM) to assess changes in PC cell viability after 48 hours of treatment to …
Characterization Of Bacteriophage Targeting Bacillus Licheniformis In Milk Processes And Thermal Stability Of Bacteriophage During Htst Pasteurization, Jeremy Robert Arbon
Characterization Of Bacteriophage Targeting Bacillus Licheniformis In Milk Processes And Thermal Stability Of Bacteriophage During Htst Pasteurization, Jeremy Robert Arbon
Theses and Dissertations
An array of Bacillus licheniformis strains were isolated from a commercial powdered milk process. Bacteriophages exhibiting activity against B. licheniformis were isolated from cattle manure and effluent samples destined for a lagoon at a dairy farm. After sequencing, 8 of the 10 phages were found to be novel and genetically differentiated. Transmission electron scanning microscopy (TSEM) was performed. All bacteriophages were of the family Herelleviridae with contractile tail sheaths ranging from 80µm to 150µm and, surprisingly, survived a common fluid milk processing treatment used to inactivate vegetative cells. The survival of the phage after high temperature short time pasteurization of …
Active Targeting Of Estrogen Receptor (Er)-Positive Breast Cancer Cells Using Nanotechnology, Molly White
Active Targeting Of Estrogen Receptor (Er)-Positive Breast Cancer Cells Using Nanotechnology, Molly White
Theses and Dissertations
The American Cancer Society has predicted an estimated 281,550 new invasive breast cancer cases for 2021. Chemotherapy is one of the main options available to treat this disease, but it can result in drug resistance and harmful side effects, as traditional methods do not directly target the cancer cells. To address this issue, nano formulations have been widely researched for targeted delivery of anticancer drugs. The primary objective of this project was to develop a novel nanodrug, rapamycin-loaded gold nanorods functionalized with polyethylene glycol and epithelial cell adhesion molecule (EpCAM), to selectively target breast cancer cells. The work involved characterizing …
Atypical Sensory Processing And Semantic Language In Autistic Children, Charlene L. Cooper
Atypical Sensory Processing And Semantic Language In Autistic Children, Charlene L. Cooper
Theses and Dissertations
Autistic children demonstrate a constellation of traits with varying degrees of severity in areas including language differences, restrictive and repetitive behaviors, and sensory processing differences. However, the relationship between sensory processing and these other behaviors are not well understood especially their neurobiological underpinnings. Therefore, this research examined behavioral measures of semantic language, sensory traits, and associated brain networks in 20 autistic children (ages 6-11) and 22 typically developing (TD) age matched peers. Mann-Whitney U tests revealed a strong correlation between sensory traits and general composite and semantic language in both groups of participants. Sensory seeking traits were most significantly correlated …
Modeling A Human Family Network, Rebecca Jo Flores
Modeling A Human Family Network, Rebecca Jo Flores
Theses and Dissertations
We propose a model that generates a family network based on real-world family network data. We use this model to study the extent to which distances to union and the number of children characterize family networks. To determine how accurate our model is we use persistent homology to identify and compare the structure of our modeled family networks to real-world family networks. To accomplish this, we introduce the notion of a network's persistence curve, which encodes the network's set of persistence intervals. Using the bottleneck distance allows us to measure the difference in the homological structure between any pair of …
Forms Of Femininity: The Esoteric Visual Language Of Amazigh Women Through Ceramic Traditions And Symbolic Motifs, Mackenzie Nunnally
Forms Of Femininity: The Esoteric Visual Language Of Amazigh Women Through Ceramic Traditions And Symbolic Motifs, Mackenzie Nunnally
Theses and Dissertations
Amazigh women exercise agency and maintain autonomy as individuals through an esoteric feminine visual language. This language incorporates traditional, ritual-based pottery-making practices that are grounded in ancient spiritual beliefs and socio-cultural roles. Highly functional yet artistic ceramicwares serve as forms of femininity, or visual representations of the women. Decorative yet decidedly symbolic, geometric motifs decorate these wares and serve as esoteric signifiers of Amazigh heritage while allowing the female artisans to communicate their own experiences, principles, and worldviews. This esoteric visual language is defined and analyzed by connections made between ancient aspects of Amazigh culture and ritual-based pottery-making practices, comparing …
Implementing Food Science-Based Instruction In Career Technical Education Courses, Jasmine D. Hendrix
Implementing Food Science-Based Instruction In Career Technical Education Courses, Jasmine D. Hendrix
Theses and Dissertations
Students are exposed to food concepts in agriculture-based career technical education (CTE) courses which provide a gateway for students to become more aware of food science career pathways. Professional development for Mississippi (MS) CTE teachers is needed to effectively implement food science-based instruction since there is not a food science curriculum framework adopted in MS. The objective of this study was to assess a food science professional development training for MS CTE teachers that would increase their self-perceived knowledge of food science, self-perceived ability to conduct food science skills, and their self-efficacy to implement food science-based instruction. Thirty-one teachers participated …
Electrocatalytic Oxidation Of Carbohydrates Via Surface Immobilized Viologen, Dallin D.V. Scott
Electrocatalytic Oxidation Of Carbohydrates Via Surface Immobilized Viologen, Dallin D.V. Scott
Theses and Dissertations
Earths most abundant biomolecules, carbohydrates, offer tremendous potential forelectricity production. Carbohydrate fuel cells are electrical fuel cells that can harvest the stored electrons in carbohydrates and offer a cheap and efficient method that could help solve growing energy demands, while providing a renewable green energy source. Viologen-mediated carbohydrate fuel cells have demonstrated the ability to accelerate carbohydrate oxidation while decreasing partial or incomplete oxidation products reducing the electricity production. Subsequent studies suggested polymeric viologen compounds could improve the efficiency by increasing the local concentration of viologen. This thesis presents the utility of surface-immobilized viologen mediators for the oxidation of simple …
Phylogeny And Visual System Evolution In Sap Beetles (Coleoptera: Cucujoidea: Nitidulidae), Gareth S. Powell
Phylogeny And Visual System Evolution In Sap Beetles (Coleoptera: Cucujoidea: Nitidulidae), Gareth S. Powell
Theses and Dissertations
Coleoptera is currently the most diverse lineage of life on Earth with more than 400,000 described species. The group also contains unbelievable ecological and morphological variation that has been evolving since the early Carboniferous (>350 MYA). The group provides the perfect playground to test evolutionary hypotheses with large-scale phylogenies. First, a newly developed bioinformatics tool is presented that allows for the critical assessment of the stability of phylogenetic nodes with even minor changes in taxon sampling (i.e. a single taxon jackknifed). The tool, TANOS, is capable of performing tests on large genomics-scale datasets. The case study included is a …
Galectin-1: Development Of A Novel Protein Therapy For Lgmd2b, Mary Lorena Vallecillo Munguia
Galectin-1: Development Of A Novel Protein Therapy For Lgmd2b, Mary Lorena Vallecillo Munguia
Theses and Dissertations
Muscular dystrophies are a heterogeneous group of genetic diseases that involve mutations in genes leading to progressive muscular weakness. Limb-Girdle Muscular Dystrophy 2B (LGMD2B) is a subset of muscular dystrophy caused by mutations in the DYSF gene, which encodes for dysferlin protein and has an incidence of 1/100,000-1/200,000 people, or 1/300 people of Libyan Jewish descent. Since there is no effective treatment that can cure or reverse effects of LGMD2B once diagnosed, our goal is to investigate and develop a protein therapy that mitigates effects of this disease in patients. Galectin-1 (Gal-1) is a small, soluble 14.5 kDa protein with …
Microwave-Promoted Iminyl Radical Fragmentations And The Total Synthesis Of Yaku'amide A And Its Simplified Analogues, Concordia Lo
Microwave-Promoted Iminyl Radical Fragmentations And The Total Synthesis Of Yaku'amide A And Its Simplified Analogues, Concordia Lo
Theses and Dissertations
The first project in this dissertation describes the use of microwave-promoted iminyl radical fragmentations to form functionalized nitriles. Nitrogen-centered radical chemistry is a useful tool to construct valuable C-N bonds commonly found in pharmaceuticals and biologically active molecules. Classically, these reactions require the use of toxic initiators and propagators. Iminyl radical chemistry has been gaining momentum as a means of avoiding these harsh conditions. This project utilizes the fragmentation of cyclic iminyl radicals via irradiation of O-phenyl oxime ethers to produce a synthetically useful nitrile tethered to an alkyl radical in the absence of metal catalysts and redox chemistry. The …
Modulation Of Effector Gene Expression In The Blood-Feeding Arthropods Cimex Lectularius Linnaeus, (Hemiptera: Cimicidae) And Aedes Albopictus Skuse, (Diptera: Culicidae), Travis C. Van Warmerdam
Modulation Of Effector Gene Expression In The Blood-Feeding Arthropods Cimex Lectularius Linnaeus, (Hemiptera: Cimicidae) And Aedes Albopictus Skuse, (Diptera: Culicidae), Travis C. Van Warmerdam
Theses and Dissertations
Hematophagy, or blood-feeding behavior, has independently evolved multiple times in the class Insecta and results in the transmission of vector-borne parasites, bacteria and viruses causing 17% of all infectious diseases and over 700,000 human deaths annually. One of the major challenges in studying the discrete mechanisms involved in host-response to hematophagy or the host seeking behavior of hematophagous insects, is the vast amount of signaling processes and genes that are inextricably tied to these interactions. These experiments used the clustered regularly interspersed short palindromic repeat (CRISPR)/CRISPR-associated (Cas) and dsRNA knock-down technologies to examine mechanisms of immunological reactivity and host-seeking behavior. …
Evaluation Of The Utility And Performance Of An Autonomous Surface Vehicle For Mobile Monitoring Of Waterborne Biochemical Agents, Jessica Simmerman Wolfe
Evaluation Of The Utility And Performance Of An Autonomous Surface Vehicle For Mobile Monitoring Of Waterborne Biochemical Agents, Jessica Simmerman Wolfe
Theses and Dissertations
Real-time water quality monitoring is crucial due to land utilization increases which can negatively impact aquatic ecosystems from surface water runoff. Conventional monitoring methodologies are laborious, expensive, and spatio-temporally limited. Autonomous surface vehicles (ASVs), equipped with sensors/instrumentation, serve as mobile sampling stations that reduce labor and enhance data resolution. However, ASV autopilot navigational accuracy is affected by environmental forces (wind, current, and waves) that can alter trajectories of planned paths and negatively affect spatio-temporal resolution of water quality data. This study demonstrated a commercially available solar powered ASV equipped with a multi-sensor payload ability to operate autonomously to accurately and …
Seasonal Management Strategies For Tarnished Plant Bug, Lygus Lineolaris (Palisot De Beauvois), In Midsouth Cotton Production Systems, Ryan Taylor Mann
Seasonal Management Strategies For Tarnished Plant Bug, Lygus Lineolaris (Palisot De Beauvois), In Midsouth Cotton Production Systems, Ryan Taylor Mann
Theses and Dissertations
The tarnished plant bug, Lygus lineolaris (Palisot de Beauvois), is considered the most economically important pest of midsouth cotton. This study was designed to understand the impact of tarnished plant bug populations in the later weeks of flowering cotton and residual effects of novaluron with subsequent applications. Experiments evaluated dynamic threshold approaches in the later flowering period of midsouth cotton, the impacts of novaluron plus subsequent applications at the 3rd week of square, as well as residual properties in a laboratory experiment. Results suggest that a dynamic late season approach can reduce the amount of insecticide applications targeting tarnished …
Molecular, Somatic, And Performance Characteristics Of Broilers Exhibiting Woody Breast Myopathy, And The Effects Of Dietary And Challenge Intervention Strategies, Linan Jia
Theses and Dissertations
Woody breast (WB) is a meat quality problem that has caused significant economic losses for the poultry industry. Ross × Ross 708 chicks were randomly assigned to a 3 (diet) × 2 (cocci challenge) × 2 (sex) factorial arrangement of treatments. The three diets included the control diet (corn-soybean meal basal diet), antibiotic diet (basal diet + 6.075 mg bacitracin /kg feed), and probiotic diet (basal diet + 2.2 × 108 CFU Bacillus subtilis PB6 /kg feed). Birds in the cocci challenge treatment group received 20 × the live cocci vaccine as an inoculum on d 14. Growth performance and …
Genetic Characterization Of Antimicrobial Activities Of Endophytic Bacteria Burkholderia Strains Ms455 And Ms389, Jiayuan Jia
Genetic Characterization Of Antimicrobial Activities Of Endophytic Bacteria Burkholderia Strains Ms455 And Ms389, Jiayuan Jia
Theses and Dissertations
Strains MS455 and MS389, endophytic bacteria, were isolated from healthy soybean plant growing adjacent to a patch of plants affected by charcoal rot disease, caused by the fungal pathogen Macrophomina phaseolina. The complete genomes of both strains were sequenced and identified as Burkholderia species Strain MS455 exhibits broad-spectrum antifungal activities against economically important pathogens, including Aspergillus flavus. Random and site-specific mutations were employed in discovery of the genes that share high homology to the ocf gene cluster of Burkholderia contaminans strain MS14, which is responsible for production of the antifungal compound occidiofungin. RNA-seq analysis demonstrated ORF1, a …