Digital Commons Network^™

Rational Design Of Metal-Organic Frameworks (Mofs)-Based Functional Materials Towards Better Air Quality, Zan Zhu

Theses and Dissertations

Air pollution is a major threat to environmental safety and public health. Volatile organic compounds (VOCs), particulate matter (PM), and airborne microorganisms are three typical air pollutants. Conventional strategies to prevent and mitigate air pollution have been employed, which, however, are generally passive. For instance, VOC sensing through solid-state devices is a conventional approach, which, however, is not capable of capturing and removing VOCs. On the other hand, air filters and face masks are useful equipment to protect people from inhaling PM and airborne microorganisms. But most commercial filters can only capture them on the surfaces, which may cause secondary …

Clear Aligner Therapy In The Mixed Dentition: Indications And Practitioner Perspectives, Nicholas M. Lynch

Theses and Dissertations

Introduction: This study evaluated current trends and perspectives among orthodontists regarding clear aligner therapy in the mixed dentition (CAMD), including insights into perceived indications, compliance, oral hygiene, and other factors.

Methods: An original, 22-item survey was mailed to both a randomized, nationally representative sample of practicing orthodontic specialists (n = 800) and to a specific, randomized sub-sample of high-aligner-prescribing orthodontists (n = 200). Questions assessed respondents’ demographic information, experience with clear aligner therapy, and perceived advantages/disadvantages of CAMD compared to fixed appliance therapy (FA). Responses were compared using McNemar’s chi-squared and paired t-tests to assess CAMD versus FA. …

Coupled Structure-Function Responses To Disturbance: High Structural Complexity Resistance Supports Primary Production Resistance, Kerstin M. Niedermaier

Theses and Dissertations

The capacity of forests to resist structural change and retain material legacies–the biotic and abiotic resources that persist through disturbance–is crucial to sustaining ecosystem functioning after disturbance. However, the role of forest structure as both a material legacy and feature supporting carbon (C) cycling stability following disturbance has not been widely investigated. We used a large-scale disturbance manipulation to ask whether LiDAR-derived canopy structures as material legacies drive 3-year responses of NPP to a range of disturbance severity levels. As part of the Forest Resilience Threshold Experiment (FoRTE) in northern Michigan, USA we simulated phloem-disrupting disturbances at a range of …

Varied Levels Of Fructose Consumption Induce Physiological, Cognitive, And Mitochondrial Alterations In Aged Female Rats, Emilie L. Bjerring

Theses and Dissertations

Since the 1970s, fructose consumption has dramatically increased within the United States, as well as the world. While adolescents tend to be the largest consumer of fructose, mostly seen in the form of sugary beverages, the consequences of a high fructose diet started in adulthood can also have severe implications on physiological parameters as well as cognition. Several studies have linked fructose consumption to metabolic syndrome, a clustering of symptoms related to overall health, with particular emphasis placed on obesity, type II diabetes, and the relationship with Alzheimer’s Disease. These findings largely stem from the outcomes of studies on cognition, …

Direction Modulated Brachytherapy For The Treatment Of Cervical Cancer, Dylan Richeson

Theses and Dissertations

Purpose: To evaluate and compare the performance of 9 experimental DMBT tandem models of varying physical dimensions in relation to 24 previously planned HDR cervical cancer treatment plans from multiple institutions that used conventional tandem and rings or ovoid applicators.

Methods and Materials: The DMBT tandem is designed to be used concurrently with IGABT and is made from an MRI-compatible tungsten-alloy rod with 6 channels grooved out of its periphery. 9 experimental DMBT tandem prototypes were provided. Each of the models was of equal lengths but varied in thickness, channel diameter size, and circle channel diameter size. Replanning …

Investigating The Effects Of Psilocybin On Models Of Anxiety, Recognition Memory, And Depression-Like Behavior And The Role Of The 5-Ht2a Receptor In Mediating Psilocybin’S Impact On Behavioral Despair, Nikita Thakur

Theses and Dissertations

Psychedelics are a class of hallucinogenic substances that exert their effects through serotonin (5-HT) receptor agonism, particularly at the 5-HT₂ receptor, which is further characterized into the 2A, 2B, and 2C subtypes. While some research studies indicate that psychedelics mediate their effects via 5-HT_2A receptor agonism, others show that it is not necessary to induce these effects. Recently, there has been a growing interest in psychedelic-assisted therapy as a promising alternative for treatment of anxiety and depression, two of the most common psychiatric disorders worldwide associated with significant morbidity. Although antidepressants and pharmacological interventions for anxiety have revolutionized …

The Interaction Of Moral Identity And Recognition On Fundraising Behavior, Craig O. Fulton

Theses and Dissertations

The research examined the role of moral identity in motivating prosocial behavior, specifically volunteer fundraising measured in dollars via Facebook fundraisers for the Spina Bifida Association, a national nonprofit organization. I predicted a three-way interaction of moral identity symbolization, internalization, and recognition (i.e., public acknowledgment of the gift by the organization) to predict prosocial behavior. When moral identity internalization is low, I hypothesized that high moral identity symbolization will motivate recognized prosocial behavior due to the opportunity to have one’s prosocial behavior in a public venue. In contrast, when moral identity internalization is high, prosocial behavior would be motivated regardless …

Exosomal Mirnas As Biomarkers For Radiation Toxicity In Breast Cancer Patients, Mina V. Mcginn

Theses and Dissertations

Radiotherapy (RT) is a standard treatment for most breast cancer patients (BCPs), but is often accompanied by acute and late toxic effects in normal tissue. Exosomes are nano vesicles about 30-150nm in size that originate from the endosomal network and are found in most body fluids. Exosomes are a fundamental driver of intercellular communication by transferring proteins, lipids and microRNA (miRNA). Exosomal miRNA (Exo-miRNA) signatures may serve as non-invasive prediction biomarkers of post-radiation toxicities of BCPs. Eighty six BCPs treated in the Radiation Oncology Department were enrolled in an IRB approved study. BCPs were evaluated weekly during RT and at …

Theta Burst Brain Stimulation In Painful Diabetic Neuropathy Patients: Investigating Neural Mechanisms, Bhushan Thakkar

Theses and Dissertations

Chronic pain (CP) is a significant contributor to disability and disease burden globally. In 2019, approximately 50.2 million adults (20.4% of the US population) experienced chronic pain, contributing to $560-635 billion in direct medical costs. In addition, the worldwide prevalence of diabetes mellitus has reached epidemic proportions and is set to increase to 629 million by 2045. Almost 50% of patients with diabetes present with diabetic neuropathy (DN), and one in five patients with diabetes presents with painful DN (pDN) which is the most common cause of neuropathic pain (NP) in the US. Symptomatic treatment is the mainstay of management …

Anthracyclines Attenuate The Nrf1-Mediated Bounce-Back Response, Bader Albalawi

Theses and Dissertations

Proteasome inhibitors, such as carfilzomib, are FDA-approved to treat multiple myeloma and mantle cell lymphoma. Unfortunately, proteasome inhibitors have only produced clinically significant results in patients with hematologic cancers, despite their predicted pan-cancer utility, and even hematologic cancer types frequently show intrinsic and acquired resistance.

One proposed mechanism responsible for the proteasome inhibitors' shortcomings is the NRF1-mediated bounce-back response. Identification of drugs that can potentiate the action of proteasome inhibitors could overcome resistance in patients with hematologic cancers and expand proteasome inhibitors' use to treat solid tumors. Our previous studies have identified anthracyclines as potential compounds that interfere with the …

Examining Ayahuasca Constituents At 5-Ht2a Receptors In Search Of Antidepressant Action, Jeremy D. Rolquin

Theses and Dissertations

Recently, it has been reported that ligands of the 5-HT_2A receptor can have drastic and fast-acting efficacy towards a number of different mental health disorders, such as depression and anxiety. A mixture of Amazonian plants calledayahuasca contains multiple compounds which have been shown to interact with the serotonergic system, and the 5-HT_2Areceptor in particular.

The structurally similar compounds (DMT, harmine, harmaline, and tetrahydroharmine) found in ayahuasca were examined for differences in their physiochemical properties that might contribute to their binding affinity for the 5-HT_2Areceptor. 3D Molecular modeling and docking studies of these compounds were …

Quantifying Contributions Of Climate, Geography, And Gene Flow To Divergence: A Case Study For Three North American Pines, Constance E. Bolte

Theses and Dissertations

Long-lived species of trees, especially conifers, often display weak patterns of reproductive isolation, but clear patterns of local adaptation and phenotypic divergence. Discovering the evolutionary history of these patterns is paramount to a generalized understanding of speciation and the processes that confer population persistence versus those that compromise adaptive potential under rapidly changing environments. Forest trees have long generation times and low migratory potential making them especially vulnerable to population fragmentation and reductions of genetic diversity due to insufficient tracking of niche optima and adaptational lags. Within clades of the genus Pinus, evolutionary histories appear to be riddled with hybridization …

A Method For Predicting Dose Changes For Hn Treatment Using Surface Imaging, Sarah E. Holler

Theses and Dissertations

Head and neck cancer is commonly treated with a six- to seven-week course of radiotherapy, during which a patient’s anatomy may change substantially, due to target reduction or weight loss. Anatomical changes lead to reduction in treatment quality due to decreased setup reproducibility and altered dose deposition compared to the original plan. Few clinics have developed a standard method for triggering resimulation and replan due to anatomic changes. This work investigates a new method for determining when to resimulate and replan HNC patients by utilizing their topographic anatomical changes to predict differences in planned versus delivered dose distributions. The first …

Outcome Of Vital Pulp Therapy On Immature Permanent Teeth With Calcium Silicate-Based Materials: Retrospective Cohort Study, Brian I. Hone

Theses and Dissertations

Introduction: The purpose of vital pulp therapy is to maintain pulp viability by eliminating bacteria from the dentin-pulp complex and to establish an environment in which apexogenesis can occur. The aim of this retrospective cohort study was to evaluate the clinical and radiographic outcomes of vital pulp therapy on immature permanent teeth using different calcium silicate-based materials. Methods: This study was carried out in the Virginia Commonwealth University Graduate Endodontics department in Richmond, Virginia. Vital pulp therapy cases performed by graduate endodontic residents were retrospectively searched and charts were reviewed to determine inclusion into this study. All cases …

Prioritizing Gifted Pedagogy In Middle School Honors: A Delphi Study, Bailey Nafziger

Theses and Dissertations

This research explores the perceptions of gifted specialists and middle school honors teachers to determine which elements from gifted pedagogy can be used to motivate gifted adolescents in an honors classroom setting. In addition, the priorities of gifted specialists and honors classroom teachers were compared to highlight key patterns. The Delphi approach was used to facilitate three rounds of anonymous collaboration between the two expert groups. Three priorities emerged through the collaboration: 1) critical thinking, 2) acceleration, and 3) goals of the class and curriculum. While social emotional issues were priorities in initial rounds, no social emotional priorities were selected …

Effects Of Fractional Gravity On Human Gait, Elizabeth Nicole Smith

Theses and Dissertations

Only twelve humans have stepped on the Moon for a mere 80 hours. Further, noneof that Lunar exposure has been within the last 50 years. NASA’s Artemis Program recently announced that the next manned missions to the Moon will be scheduled for 2024 and 2025. With only a few years to prepare, it is pertinent that training for prospective astronauts reflects current scientific knowledge to ensure safety. In this study, the coordinative gait structures under 1.0g (Earth), as well as simulated 0.38g (Martian) and 0.17g (Lunar), were analyzed to discover critical changes in gait that may occur in these environments. …

Meta-Analysis For Comparing Effect Between Game-Based Learning Versus Gamification Utilized In Nutrition Education, Chia-Lin Chang

Theses and Dissertations

The prevalence of obesity tripled from 1975 to 2016 and was declared as a global epidemic by the World Health Organization (WHO) in 1997 (Haththotuwa et al., 2020; "Controlling the global obesity epidemic," 2022). Nutrition education that involves knowledge and behavioral change is one major component addressing the problem ("Controlling the global obesity epidemic," 2022). Therefore, the effectiveness of each learning session is essential (Sharifirad et al., 2013). Thus, many nutrition educators have used gamified nutrition education to improve teaching effectiveness to increase healthy behavior or knowledge (Chow et al., 2020.; Munguba et al., 2008; Azevedo et al., 2019). Two …

Factors Influencing Levels Of Secondary Traumatic Stress In Non-Offending Caregivers Of Children With Sexual Or Physical Abuse Histories, Ani Mangold

Theses and Dissertations

The present study examined factors influencing levels of secondary traumatic stress (STS) in non-offending caregivers (NOCs) of children with histories of sexual or physical abuse. These factors included the nature of the abuse, NOCs’ relationships with the initiators of the abuse, children’s ages and genders, NOCs’ genders, NOCs’ personal trauma histories, familial structures, and the elapsed time between children’s disclosures of abuse and their trauma assessments. As a secondary objective, the present study examined the interactions between children’s self-reports of their own posttraumatic stress disorder (PTSD) symptomatology, NOCs’ estimates of their children’s PTSD symptomatology, and NOCs’ self-reports of their own …

The Impact Of Traumatic Experiences On Women's Mental Health: The Moderating Effect Of Violent Media Consumption, Erika Meierding

Theses and Dissertations

Introduction: Prior research informs us that negative mental health outcomes are associated with childhood trauma (Chapman et al., 2004; Widom, 1999) and with exposure to violence in the media (Hopwood & Schutte, 2017). Given the prevalence of violence against women (VAW) both in the media and in society in general, it is important to understand how VAW in the media may uniquely impact the mental health of women who have previous experiences of childhood trauma. Objective: Drawing from cultivation theory and the diathesis stress model of mental health, this study examined the moderating role of exposure to VAW in the …

Palmitic Acid Impedes Extravillous Trophoblast Activity By Increasing Mrp1 Expression And Function, Yunali V. Ashar

Theses and Dissertations

Normal function of placental extravillous trophoblasts (EVT), which are responsible for uteroplacental vascular remodeling, is critical for adequate delivery of oxygen and nutrients to the developing fetus and normal fetal programming. Proliferation and invasion of spiral arteries by EVT depends upon adequate levels of folate. Multidrug resistance-associated protein 1 (MRP1), which is an efflux transporter, is known to remove folate from these cells. We hypothesized that palmitic acid (PA) increases MRP1-mediated folate removal from EVT, thereby interfering with EVTʼs role in early placental vascular remodeling. HTR8/SVneo and Swan-71 cells, first trimester human EVTs, were grown in the absence or presence …

Psychosocial Factors In Fibromyalgia: A Phenomenological Understanding Of The Experiences Of Latinas, Elisenda Rodes

Theses and Dissertations

Fibromyalgia (FM) is a syndrome characterized by chronic, widespread musculoskeletal pain. Its prevalence is estimated to be about 2% to 5% of the adults in the United States (Arnold et al., 2019). However, significant variations exist in this respect, due to a lack of consensus about the guidelines for FM diagnosis by physicians. FM symptoms are not restricted to pain, and often include fatigue, anxiety, depression, somatic and cognitive symptoms, and poor quality of life. Although its etiological causes are still not clear, important psychological, social, and cultural factors have been linked to the onset, maintenance, and to the ways …

Treating Gut Feelings: A Systematic Review Of Psychological Treatments For Pediatric Inflammatory Bowel Disease, Venus Mirbod

Theses and Dissertations

Psychological comorbidities and psychosocial challenges are prevalent among children and adolescents with Inflammatory Bowel Disease (IBD). However, a comprehensive review of the availability and effectiveness of psychological treatments for pediatric IBD patients is lacking. This systematic review aimed to determine the availability and efficacy of psychological interventions for children and adolescents with IBD. The systematic review was conducted in accordance with PRISMA guidelines and performed using two electronic databases, PsycINFO and PubMed, from inception until March 2022. Databases were searched for English-language, controlled trials of psychological interventions for children and adolescents with IBD. Outcomes of interest included: depression, anxiety, health-related …

Purpose Built Communities: A Concentrated Urban Poverty Intervention, Shannon R. Bergman

Theses and Dissertations

This collective case study research evaluated how the concentrated urban poverty revitalization model administered by Purpose Built Communities (PBC) works to mitigate or eliminate intergenerational poverty and create thriving neighborhoods. There are 5 elements to the PBC revitalization model: (a) mixed-income housing, (b) a cradle-to-college educational accountability system, (c) focus on community health, (d) a tightly defined geographic neighborhood, and (e) the assignment of a Community Quarterback (CQ). This research demonstrated iterative improvements in the socioeconomic well-being of adults and children from the inception of the revitalized community. This was evaluated by adult employment rates, childhood educational achievement, and health …

The Chemistry Laboratory Experience Of El Camino Students While In Emergency Remote Teaching Due To The Covid-19 Pandemic, Shaun A. Cook

Theses and Dissertations

Future college environments, including those in chemistry, will entail flexible formats. The pandemic spurred appreciation of the need, and though it has largely passed, adaptability to multiple formats in the future has been a critical part of planning for a rapidly changing future. Experiences during the pandemic will guide pedagogical changes and practices in the future. At El Camino College in Southern California, the chemistry department provided varied laboratory instruction to students during Emergency Remote Teaching. Understanding the experience students had during this extraordinary time is essential. Students who took courses that had an online laboratory course completed a mixed-methods …

Mechanisms And Treatment Of Pain-Depressed Behavior In Male And Female Mice, Clare M. Diester

Theses and Dissertations

One of the largest discrepancies between preclinical and clinical assessment of pain and analgesia is the type of behavioral endpoint used. Although most preclinical research has historically focused on drug effectiveness to block reflexive withdrawal behaviors stimulated by a noxious stimulus, increasing evidence shows that drug-induced restoration of pain-depressed behaviors provides increased clinical translation with decreased susceptibility to false-positives. Accordingly, the first portion of this dissertation designed a behavioral battery that featured pain-depressed behaviors as well as more conventional pain-stimulated behaviors for testing candidate analgesics in male and female mice. The main findings are as follows. (1) Intraperitoneal injection of …

The Experiences Of Religiously And Spiritually Diverse Counselors And Psychotherapists Who Work With Survivors Of Sexual Violence, John M. Waters

Theses and Dissertations

The purpose of this qualitative study was to examine the lived experiences of religiously and spiritually diverse counselors and psychotherapists who work with survivors of sexual violence. The researcher used a transcendental phenomenological approach to understand how the participants engaged their religious and/or spiritual identity to cope with the traumatic stress that accompanies continuous exposure to their clients’ trauma narratives over time. As the only study that has examined these phenomena qualitatively, the present study aimed to enhance counselors and counselor educators’ understanding of the ways that religiously and spiritually diverse counselors make meaning of their experiences. The researcher collected …

Impact Of The Covid-19 Pandemic On Child Anxiety Symptoms: The Influence Of The Caregiver-Child Relationship, Rebecca Hoppe

Theses and Dissertations

Research suggests that youth are dealing with a myriad of worries during the COVID-19 pandemic (Ellis et al., 2020), which highlights the need for investigations focused on child anxiety. However, to date little research has examined children’s anxiety in the COVID-19 pandemic nor the potential protective effects of the caregiver-child relationship. Therefore, this research aimed to contribute to the literature by investigating the influence of COVID-19 related stressors in younger children and leveraging children’s report of their own attachment security within their relationship with their caregiver and mental health. The current study used a national, quantitative survey of young children …

Generation 1.5 Students’ Academic Success: The Interrelationship Between Capital Used And Identity Formation, Susan D. Dudley

Theses and Dissertations

As the number of people immigrating to the United States increases, so does the number of generation 1.5 students in K-12 education (Kanno & Cromley, 2013). With more generation 1.5 students graduating from U.S. high schools, more are also matriculating into higher education institutions (Harklau & Siegal, 2009; Kanno & Cromley, 2013; Kanno & Harklau, 2012; Roberge, 2009). While some generation 1.5 students are successful in U.S. higher education, others are not, and the percentage of generation 1.5 students who are successful is disproportionately less than the percentage of those students who have a U.S. heritage culture (Kanno & Harklau, …

Effect Of Clear Aligner Attachment Design On Extrusion Of Maxillary Lateral Incisors: A Randomized Clinical Trial, Justin Groody

Theses and Dissertations

Introduction: The aims of this randomized clinical trial were to compare the efficacy of extrusion of maxillary lateral incisors among “optimized”, rectangular “horizontal”, rectangular horizontal “incisally beveled”, rectangular horizontal “gingivally beveled” attachments, and to provide a clinically relevant recommendation for attachment planning for extrusion of maxillary lateral incisors during aligner treatment.

Methods: 30 16-to-58 year old Invisalign patients and 56 maxillary lateral incisors requiring extrusion were randomly allocated to one of four attachment groups (optimized, horizontal, incisally beveled, and gingivally beveled). Participants were recruited from two private practice offices and the Virginia Commonwealth University School of Dentistry. The outcome assessor …

Roots And Webs And Nets And Branches And Bulletin Boards And Banners And Newsletters And Mutual Aid Text Threads And Kin And Caretakers And Porches And Poems Of Today And Spaces Of Survival, Lukaza Branfman-Verissimo

Theses and Dissertations

As I welcome Richmond, VA into my family, I find myself needing to make roots and webs and nets and branches that ground me, that place myself as a Black, queer, mixed race, artist, activist, educator, storyteller, and cultural worker in this city. I am called to the streets before I am called to my studio. I question what it means to be a part of an institution that is slowly eating this city up. I become a story collector. I need to know where I am and whose land I now call home.