Digital Commons Network^™

Evaluation Of The Throw-Catch Assessment, Bryan Terlizzi

Theses and Dissertations

Motor competence assessment has been characterized by the evaluation of motor skill performance in closed performance contexts that lack task and environmental constraints reflective of real-world contexts. In contrast, the throw-catch (TC) assessment employs a dynamic task environment that allows performers to adapt over multiple trials to evaluate the degree of skilled performance via demonstration of a flexible and adaptable repertoire of both throwing and catching actions. The purpose of this dissertation was to investigate the developmental validity of the TC, as well as the content validity of the TC in terms of assessing throwing skillfulness.

Performance of the TC …

Long Non-Coding Rna Pvt1 – An Exploratory Study In Ovarian And Endometrial Cancer, Kevin Tabury

Theses and Dissertations

Gynecological cancers, ovarian and endometrial cancer, are still leading causes of cancer-related death in women worldwide. Early detection methods as well as treatment resistance remain a challenge. Long non-coding RNAs (lncRNAs) are emerging as therapeutic targets with diagnostic and prognostic potential with lncRNA PVT1 being one of them.

Here I test and demonstrate the role of PVT1 in ovarian cancer growth and metastasis. PVT1 is amplified and overexpressed in ovarian cancer and has predictive value for survival and response to targeted therapeutics. We find that expression of PVT1 is regulated by tumor cells in response to cellular stress, particularly loss …

Living With Ulcerative Colitis: Exploring Dietary Inflammatory Intake, Physical Activity, And Methods To Manage The Burden Of Illness, Kelli E. Dubois

Theses and Dissertations

Ulcerative Colitis (UC) is a chronic illness under the umbrella of Inflammatory Bowel Disease (IBD). IBD is becoming a global health issue as incidence rates are rising throughout the world. UC is characterized by chronic inflammation and ulcerations in the colon’s mucosal lining due to abnormal inflammatory and immune system responses. Patients with UC experience a range of gastrointestinal and extraintestinal symptoms as well as psychosocial challenges throughout the course of illness that generate a significant burden on daily life. Periods of active disease, or flares, present exacerbations of disease symptoms and the greatest burden on daily functioning, yet disease …

Oxidized Graphitic Nano-Amendment Of Cement Composites: Exploring Truly Low Concentrations And Novel Particle Morphologies, Shohana Iffat

Theses and Dissertations

Oxidized graphitic nanoparticles such as multiwalled carbon nanotubes (MWCNTs) and graphene nanoplatelets (GNPs), can produce enhancements in physicomechanical properties of cement composites that are relevant to structural and durability performance, provided that said nanoparticles are well dispersed in the composite. Lower-bound MWCNT concentrations are reported in the literature in the range 0.01-0.05% in weight of cement (wt%). Such concentrations may not be costeffective for practical applications and may also be excessive since they would result in a nanoparticle surface area at or above 105 m2 for 1 m3 of cement paste, or 104.5 m2 for 1 m 3 of concrete, …

The Effect Of Pulsed Field Dc Electrophoresis And Field Amplified Sample Stacking On The Microchip Electrophoretic Separation Of Organic Dyes, Travis Geoffrey Stewart

Theses and Dissertations

The utility of field amplified sample stacking and pulsed field electrophoresis toward improving electrophoretic outcomes was studied with regards to the electrophoretic separation of three organic dyes rhodamine B, 2’,7’-dichlorofluorescein, and fluorescein salt in microchip electrophoresis conditions. In this study, there were four experimental groups: nonstacking nonpulsed, nonstacking pulsed, sample stacking nonpulsed, and sample stacking pulsed.

Electrophoretic outcomes were evaluated by examining the electrophoretic separations under an epifluoresence detection method, plotting the signal intensities vs. time, and comparing separation resolutions and signal-to-noise ratios between experimental groups. From this it was shown that sample stacking nonpulsed conditions yielded the best outcome …

Qualitative Action Research Into The Planning Between The Classroom Teacher And Reading Interventionist, Russell Derrial Clark

Theses and Dissertations

Students reading below grade level need intense intervention. Reading is an active development that requires close collaboration by all the teachers involved in supporting struggling students. Understanding the needs of students with reading deficiencies can present challenges for teachers that are unable to work collectively to support the students. Teachers and interventionists need time to reflect on their attitudes and perceptions of planning and collaborating if they are going to help students achieve reading goals. Through the intervention of this study, the development and implementation of collaborative planning, teachers will be better prepared to meet the needs of their students. …

Crystal Growth Of Inorganic Halides And Oxide-Halides For Scintillation Applications And Radiation Detection, Gyanendra B. Ayer

Theses and Dissertations

Scintillators, materials which emit light when struck by high energy X-rays and y- rays, are extensively used in various fields including medical imaging, computed tomography, high-energy physics, and more recently in homeland security for the prevention of nuclear and radiological terrorism. While comparing with the traditional scintillators, which have long-term instability, high synthetic cost, toxicity, and hygroscopicity issues, metal halides have been reported to exhibit effective excitonic radioluminescence and greatly contribute in the field of scintillating applications and radiation detection. Currently, the mixed-anion oxide-fluorides have emerged as a prospective new class of scintillators, in which the mixed oxide-fluoride environment …

Integrated Behavioral Health And Primary Care: Refining A Determinant Framework, Ariel Michelle Domlyn

Theses and Dissertations

The integration of behavioral health and primary care is a best practice to improve patient outcomes and achieve health equity. However, the process of integrating is opaque, requiring organizational change and sometimes a complete system overhaul. Implementation science offers useful ideas for helping healthcare organizations to implement care. This field has identified potential environmental conditions and determinants of successful implementation; however, much is still unknown about how these factors may be relevant for organizations seeking to integrate care. To address the limited existing knowledge in this area, this dissertation gathers practice-based evidence using exploratory methods. Results are translated into an …

The Development Of A Monolithic Spatial Heterodyne Spectrometer For Extreme Environments, Arelis Michelle Colόn

Theses and Dissertations

This work describes improvements to a novel instrument, the monolithic spatial heterodyne Raman spectrometer (mSHRS), which has potential to be utilized in space exploration and deep-ocean marine sensing. In previous work, the spatial heterodyne Raman spectrometer (SHRS) was demonstrated, as a small, high resolution, wide field of view spectrometer, originally developed for space applications where small size and compactness is a key consideration or where a wide field of view is advantageous, such as in remote spectroscopy. The spatial heterodyne spectrometer (SHS) was then later utilized for remote Laser-Induced Breakdown Spectroscopy (LIBS). The high throughput, high spectral resolution, and large …

Role Of Epigenome In Regulation Of Inflammation By Ahr Ligands 2,3,7,8-Tetrachlorodibenzo-P-Dioxin And 6-Formylindolo[3,2-B] Carbazole, Alkeiver Cannon

Theses and Dissertations

Autoimmune Hepatitis (AIH) is a chronic inflammatory disease of the liver mediated by immune cells and characterized by a variety of parameters including circulating autoantigens, elevated immunoglobulin G (IgG) and aminotransferases, and interface hepatitis. Unfortunately, despite treatment with broadly immunosuppressive drugs, the disease progresses to cirrhosis and end-stage liver disease in several cases. In order to develop a more specific treatment, the mechanisms governing the liver injury resulting from inflammation and autoimmunity need to be elucidated.

For decades, activation of Aryl Hydrocarbon Receptor (AhR) was excluded from consideration as a therapeutic approach due to the potential toxic effects of AhR …

Evaluation Of Monthly And Seasonal Grazing Rates Of Ilyanassa Obsoleta On Benthic Microalgae In The North Inlet Estuary, Brittany Dearmitt

Theses and Dissertations

The eastern mud snail, Ilyanassa obsoleta, is found at densities of 100’s of individuals m^-2 on soft sediments in the intertidal zones of estuaries. These obligate deposit feeders consume microalgae, detritus, larvae, meiofauna, and macrofauna in the surface layers of sediments with possible trophic impacts on benthic microalgal (BMA) biomass. The goals of this study were to quantify mud snail grazing on BMA biomass, observe the variation in monthly and seasonal grazing rates, and evaluate the relationship between atmospheric temperatures and grazing rates. The sites for this experiment were two mudflats in Oyster Landing, North Inlet estuary, South …

A Novel Cognitive Stress Paradigm To Assess Subtle Cognitive Differences In Women With The Fmr1 Premutation, Jillian Margaret Gierman

Theses and Dissertations

Fragile X premutation (FXPM) is a genetic mutation of the FMR1 gene characterized by having between 55-200 CGG repetitions. FXPM women are at risk for a variety of reproductive, cognitive, and neuropsychiatric deficits, including fragile X-associated primary ovarian insufficiency (FXPOI) and fragile X-associated tremor/ataxia syndrome (FXTAS). FXTAS is a late-onset neurodegenerative disorder characterized by tremor, gait ataxia, cognitive decline, brain atrophy, and deficits in executive functions. With the evidence supporting premature aging, prevalence of cognitive deficits, and risk of developing FXTAS and dementia, it is imperative to find a reliable measure that identifies at-risk FXPM women and their subtle cognitive …

Mass Spectrometric Investigation Of Removal/Transformation Of Emerging Contaminants For Safer Potable Wastewater Reuse, Kristin Cochran

Theses and Dissertations

Water scarcity is of increasing global concern as rising demand depletes current sources, so other sources such as potable wastewater reuse are being utilized. Advanced wastewater reuse removes pathogens and many contaminants, but there are concerns about resistant contaminants and the transformation products that are generated during the treatment process. This research focuses on several different contaminant classes, how well they are removed via advanced treatment processes, what transformation products arise from both advanced treatment and chlorination disinfection, and how those treated waters may impact health via toxicity and estrogen activity.

Contaminant classes considered are illicit drugs, pharmaceuticals such as …

La Materialidad De Las Vivencias Femeninas: Cuerpos Discapacitados, Prostituidos Y Violados En Las Narrativas Mexicanas Escritas Por Las Mujeres, Hyanghee Lee

Theses and Dissertations

Esta disertación explora los temas específicamente vinculados a las vivencias de las mujeres mexicanas tales como la anormalidad, la discapacidad, la locura, la prostitución, la violencia de género y la madre mutilada que no pueden abordarse sin tener en cuenta el cuerpo femenino. En este proyecto se discuten estas temáticas aplicando el concepto de la corporeidad o la materialidad de las vivencias que experimentan las mujeres en dicho espacio geopolítico manifestadas en cuatro narrativas mexicanas producidas por las mujeres-escritoras en la época contemporánea del final del siglo XX y al comienzo del siglo XXI: Nadie me verá llorar (1999) de …

Identifying Novel Pharmacogenetic Markers For Cancer Treatments: Exploiting Cancers Deficient In The Nucleotide Pool Sanitizing Hydrolases Nudt15 And Nudt18, Jacob Chandler Massey

Theses and Dissertations

The NUDIX hydrolases are a super family of enzymes with purported enzymatic activities of nucleotide hydrolases. The activity of the founding member, NUDT1 (also known as MTH1) is established to be a nucleotide hydrolase for d-8-oxoGTP, which is a mutagenic precursor if incorporated into DNA. Therefore, its activity serves to sanitize the nucleotide pool of mutagenic precursors. While known to be highly conserved among all organisms, the enzymatic and biological functions for nearly all the family members remain largely unexplored and unknown. Substrates of family members have been found to include canonical (deoxy)nucleotide triphosphates, oxidized (deoxy)nucleotide triphosphates, and non-nucleoside polyphosphates. …

Impact Of A Novel Marine Algae Supplement On Inflammatory And Immune Response After High-Intensity Exercise, Caroline Sara Vincenty

Theses and Dissertations

INTRODUCTION: High-intensity exercise (HIE) can damage the musculotendon complex and impact the immune response, which may result in post-exercise inflammation and reductions in strength and performance. Sufficient rest and recovery will improve muscular resilience against future damaging bouts, however HIE with minimal durations of rest are common in athletic competitions that facilitate persistent inflammation and immune dysregulation. Marine algae-derived fucoidans (MA) have previously shown promise to mitigate pro-inflammatory and immune dysregulation responses, however it has not been investigated in the context of HIE. The purpose of this research is to investigate the safety and efficacy of MA on markers of …

Relationships Among Sleep, Physical Activity, And Weight Status In Children And Adolescents, Agnes Bucko

Theses and Dissertations

Sleep and physical activity are both associated with multiple behavioral and metabolic health outcomes, and both behaviors have been linked to the development of weight status. Recent estimates suggest that many children are not meeting sleep recommendations or participating in adequate levels of physical activity, which may be related to the high prevalence of childhood overweight and obesity. Much of the research assessing these relationships has focused on adults and older children, and has relied on parent- or child-reported, cross-sectional research in predominantly White samples. Little work has focused on these relationships in very young children. Although more research has …

Structure Preserving Reduced-Order Models Of Hamiltonian Systems, Megan Alice Mckay

Theses and Dissertations

Large-scale dynamical systems are expensive to simulate due to the computational cost accrued y the substantial number of degrees of freedom. To accelerate repeated numerical simulations of the systems, proper orthogonal decomposition reduced order models (POD-ROMs) have been developed. When applied to Hamiltonian systems, however, special care must be taken when performing the reduced order modeling to keep their energy-preserving nature. This work presents a survey of several structure-preserving reduced order models (SP-ROMs). In addition, this work employs the discrete empirical interpolation method (DEIM) and develops an SP-DEIM model for nonlinear Hamiltonian systems. The wave equation is considered as a …

The Moderating Impact Of Gender And Friendship Quality On The Effects Of Interparental Conflict On Adolescent Internalizing Problems, Jessica Dandan

Theses and Dissertations

In response to escalating concerns about the increasing incidence of adolescent internalizing disorders, several mechanisms have been investigated to understand their etiology. Though genetic predisposition contributes to the risk for psychopathology, its interaction with environmental stressors such as interparental conflict appears to further increase this risk. Girls are more susceptible to stressors and twice as likely as boys to develop internalizing problems. However, friendship quality may buffer some of the adverse effects incurred from exposure to interparental conflict. A recent review of proposed mechanisms through which conflict is associated with youth psychopathology pinpointed the need for further adolescent-focused research including …

“No Tits In The Pits!”: An Exploratory Analysis Of The Experiences Of Female Decision Makers In Motorsports In The United States, Alexia Pedo Lopes

Theses and Dissertations

This study explored the lived experiences of sixteen women who have decision-making roles in motorsports in the United States. The purpose was to shed light on the experiences of women who broke the glass ceiling in this unexplored male-dominated industry (Glass & Cook, 2016). The challenges these women encountered along with the mechanisms they employed to navigate those, and finally their motivation to continue pursuing a career in this industry, were assessed via in-depth semi-structured interviews and then the data was analyzed following a constant comparison thematic analysis. Challenges and coping mechanisms were classified according to the four levels, namely …

Middle School Transition: The Influence Of An Academy Approach And The Role Of Leadership, Kimberly Calhoun Odom

Theses and Dissertations

Students entering middle school frequently encounter challenges in their transition as they leave the comforts of elementary school. Traditionally, fifth grade students experience their last year in elementary school in a similar fashion to the previous five years of elementary school. They are in self-contained classrooms with one teacher for the majority of their school day. This study’s objective is to determine best practices and strategies that support fifth grade students in transitioning to the rigors of middle school. More specifically, the research focuses on the impact of an Academy structure in the elementary setting that models the transitions of …

Methyltransferase Mystery: Epigenetic Mechanisms Induced By Food Limitation In Daphnia Pule, Trenton C. Agrelius

Theses and Dissertations

Daphnia are ecologically important organisms that have been well studied in the context of evolution, ecology, ecotoxicity, and genomics. Daphnia have strong maternal effects in which the environment experienced by the mother can alter offspring disease resistance, life history traits, and morphology, as well as gene expression and methylation for multiple generations. Coupled with their ability to reduce genetic differences via parthenogenesis, Daphnia are an ideal system for epigenetic studies involving the transmission of maternal effects. Using two clones of Daphnia pulex, we investigated the plasticity of life history and DNA methyltransferase (Dnmt) gene expression with respect to food …

Hybrid Theory-Machine Learning Methods For The Prediction Of Afp Layup Quality, Christopher M. Sacco

Theses and Dissertations

The advanced manufacturing capabilities provided through the automated fiber placement (AFP) system has allowed for faster layup time and more consistent production across a number of different geometries. This contributes to the modern production of large composite structures and the widespread adaptation of composites in industry in general and aerospace in particular. However, the automation introduced in this process increases the difficulty of quality assurance efforts. Industry available tools for predicting layup quality are either limited in scope, or have extremely high computational overhead. With the advent of automated inspection systems, direct capture of semantic inspection data, and therefore complete …

Cognitive Consequences Of Covid-19 Infection And Quarantine-Induced Social Isolation: Hope For The Young And Mildly Infected, Kristin Nickole Kirchner

Theses and Dissertations

Coronavirus disease 2019 (COVID-19) has infected over 539 million individuals worldwide, and initial research supports the possibility that COVID-19 may damage the central nervous system either directly or indirectly. Neurological signs and noted cognitive deficits observed in even mildly infected patients are a cause for concern for those infected by COVID-19; the effect of social isolation on the central nervous system is also of interest. The present study sought to determine the extent of these potential cognitive deficits in a young and mildly infected sample of college students. Participants completed an extensive survey assessing their experience with COVID-19 and any …

Unearthing An Emerging Neglected Bacterial Disease: Evidence Of Spotted Fever Group Rickettsioses In El Salvador, Kyndall Christian Braumuller

Theses and Dissertations

The main objectives of this dissertation were to investigate the seroprevalence of Spotted Fever Group Rickettsioses (SFGR) antibodies in a specific vulnerable population at high risk for vector-borne disease in El Salvador, understand the relevant risk factors for SFGR past and acute infection in this same population through logistic regression modeling, and clarify the presence of SFGR bacteria in locally collected ticks.

SFGR are a group of bacterial diseases caused by species in the Rickettsia genus of the phylogenetic spotted fever group. These are tick-borne diseases (TBD) that have been described in almost every region of the world. SFGR are …

Water Quality Correlations With Phytoplankton Community Composition In A Polluted Shallow Subtropical Estuary, Connor Joseph Wong

Theses and Dissertations

The Indian River Lagoon (IRL) estuary has experienced eutrophication and degraded water quality due to high nutrient input, urbanization, and anthropogenic stressors. High nutrient input and restricted estuarine hydrology promotes algal blooms. Algal blooms or harmful algal blooms (HABs) are a global concern as they can cause negative ecological and economic impacts. The frequency and range of HABs is expected to be exacerbated by climate change and altered oceanic and estuarine conditions. Research on the formation and frequency of HABs is an ongoing global effort, but algal blooms are often dynamic and patchy making them difficult to study. This study …

The Telsam Protein Polymer Significantly Improves The Speed And Propensity Of Crystallization Of Target Proteins, Seyedeh Sara Soleimani

Theses and Dissertations

While conducting pilot studies into the usefulness of fusion to TELSAM polymers as a potential protein crystallization strategy, we observed novel properties in crystals of two TELSAM–target protein fusions, as follows. (i) A TELSAM–target protein fusion can crystallize more rapidly and with greater propensity than the same target protein alone. (ii) TELSAM–target protein fusions can be crystallized at low protein concentrations. This unprecedented observation suggests a route to crystallize proteins that can only be produced in microgram amounts. (iii) The TELSAM polymers themselves need not directly contact one another in the crystal lattice in order to form well-diffracting crystals. This …

Home-Shared Reading Influences On Phonological Awareness Abilities Of Primary Students Who Experienced An Interruption Of Classroom Literacy Instruction Due To A Catastrophic Event, Alisa Maxine White

Theses and Dissertations

This qualitative study was conducted to explore emergent literacy and phonological awareness abilities of primary students who experienced an interruption of classroom literacy instruction due to a catastrophic event. Participants included four primary students and their parents. The students participated in home-shared reading regularly and missed the last nine weeks of classroom instruction during their pre-kindergarten or kindergarten school year due to a catastrophic event. The participants were observed during home-shared reading. Three research questions were used to explain the study: 1) When children are read to at home and miss the last nine weeks of school, what phonological behaviors …

Consequences Of Microsporidian Prior Exposure For Virus Infection Outcomes And Bumble Bee Host Health, Elyse Christine Mccormick

Theses and Dissertations

Host-parasite interactions do not occur in a vacuum, but in connected multi-parasite networks. Resulting co-exposures and coinfections during an individual host’s lifetime can affect host health and infectious disease ecology, including disease outbreaks. However, many host-parasite studies examine pairwise interactions, meaning we still lack a general understanding of the influence of co-exposures and coinfections. Using the bumble bee Bombus impatiens, we study the effects of larval exposure to a microsporidian Nosema bombi, implicated in bumble bee declines, and adult exposure to Israeli Acute Paralysis Virus (IAPV), an emerging infectious disease from honey bee parasite spillover. We hypothesize that infection outcomes …

Development Of Enhanced Food Packaging Systems Based On Blends Of Bio-Based And Biodegradable Polymers Exhibiting Antimicrobial Properties, Aishat Agboluaje

Theses and Dissertations

Food packaging is one of the important aspects of food processing, which contributes greatly to decreasing post-harvest food losses. While ensuring that foods are adequately packaged, it is also important to consider the impact of these food packaging materials on the environment. Accordingly, this research work was aimed at investigating the potential of bio-based and biodegradable blends of polyvinyl alcohol (PVA) and chitosan loaded with antimicrobial agents such as turmeric, clove, and cinnamon for use in food packaging applications. The methodology involved creating PVA/chitosan films with varying compositions via solvent casting method and selecting the best composition exhibiting the highest …