Digital Commons Network^™

Computational Qsar & Molecular Docking Of Anti- Inflammatory Asthma Drugs Against Human Serum Albumin: A Computational Approach Towards Drug Design & Drug Discovery, Sara Alkarimy

Theses and Dissertations

There is a growing need for medications to fight deep-rooted and new diseases because of their socioeconomic consequences, as evidenced by the COVID-19 epidemic which slowed down the economy and affected the social life of mankind globally. This work is a step among many other steps undertaken by research around the world in order to achieve this objective. Asthma is one of the diseases that causes the death of thousands of lives every year. This work aims at the development of novel anti-inflammatory asthma drugs where the quantum chemical descriptors of eleven anti-inflammatory asthma drugs including Ambroxol, Amoxicillin, Budesonide, Fluticasone, …

Visions Of Mary: Patria As The New Mestiza Madonna In Alvarez's In The Time Of The Butterflies, Mila Argueta

Theses and Dissertations

Alvarez’s In the Time of the Butterflies is a fictional depiction of three sisters who are lauded for their role in ending the supremacist, womanizing, and terror-inspiring reign of Trujillo. While, one character, Patria, seems to represent the traditional, and at times cloistered, life of a Dominican wife and mother (reflecting the Malinche and sufrida archetypes), the text also shows her transformation into one of the most vital figureheads of the revolution. I find that when she joins the revolution, she comes as a transformed Marian-figure. Unlike Ibez Gomez Vega and other feminist scholars who have categorized Patria as one …

Cytotoxic Activity Of Salvia Officinalis Extract Mediated By The Inhibition Of Jak2 In Breast Cancer, Salma Alawadi Dawood

Theses and Dissertations

Background: Breast cancer is the most common type of invasive cancer in women in their forties and fifties. Recent evidence suggests that JAK2/STAT3 signaling is constitutively active in breast cancer. Previous studies suggest that plant extracts, including Salvia Officinalis, have strong cytotoxic effects on breast cancer cells. The differential expression of miRNAs is also strongly linked to cancer development.

Aim: In the current study, we hypothesize that S. Officinalis extract suppresses JAK2 expression and has strong anticancer potential in MCF7 breast cancer cell lines.

Methods: GC-MS analysis showed the presence of flavonoids in dried leaf of …

Daughterly Narratives In Search Of Voice: Fadwa Tuqan, Latifa Al-Zayyat, And Samar Attar, Rania Bedeir

Theses and Dissertations

A myriad of pressures and struggles affect Arab women as they are coming of age due to the familial and societal constructs they face. As daughters, they yearn for a voice amidst a plethora of generational boundaries, transmissions, and ideals. The intricacy of the psychological and interconnected structural factors is augmented by their gender in societies that are motivated, and often governed by, the implications of gender roles. While multiple layers of influence such as familial and sociocultural institutions affect how consciousness is formed, generational transmission, through the maternal figure, is paramount. Daughters, therefore, cannot narrate their personal stories without …

Architectural And Heritage Experience Through Playful Learning (An Interdisciplinary And Exploratory Action Research Focused On The Egyptian Context), Atheer Ahmed Salama

Theses and Dissertations

“The lack of awareness of the value of heritage and the lack of opportunities to engage in preserving and safeguarding heritage in the public sphere not only puts the heritage in risk of being irremediably lost. It also impoverishes the younger generation’s sense of identity and belonging within its respective socio-cultural continuum, and thus limits its ability to engage and contribute meaningfully to society at large” (UNESCO, 2021). With conducting this research, the researcher believes that heritage-themed analog games may carve the younger generation’s memory of heritage, allowing them to boost their sense of identity and belonging; thus, widening their …

Combating Counterfeit Medicines: A Case Study Of The Egyptian Pharmaceutical Traceability System, Nourhan Yasser Ahmed Abdelfatah

Theses and Dissertations

Counterfeit medicines are a global challenge that has attracted the attention of many authorities in recent years. The problem worsened dramatically, causing adverse public health impacts and significant financial repercussions. Many countries, including Egypt, have attempted to adopt pharmaceutical track-and-trace systems to secure supply chains. Despite the significance of the problem, only a few scholars have studied the topic in Egypt. This qualitative study seeks to bridge the research gap and provide a clearer picture of counterfeit medicines in the Egyptian context. In addition, it aims to understand the role of the Egyptian Drug Authority and the policy motivations behind …

Fragments Of A Writer’S Mind: Virginia Woolf In Her Own Words, Baheya Zeitoun

Theses and Dissertations

This thesis provides a thematic reading of select autobiographical and theoretical works by Virginia Woolf. It utilizes Deleuze and Guattari’s philosophy of the rhizome as a methodological framework. The rhizome does not have a hierarchal structure but is rather interconnected. In the same way, the chapters interweave the multi-disciplinary theoretical approaches to connect the disparate factions of the modernist writer’s mind and life.

The early twentieth century saw the rise of post-suffrage writers with narratives that diverged from male-centric values. Woolf is one of the writers who makes a clear distinction between male and female values by championing women’s experiences …

Nutrient Optimization For Vegetable Production Under Decoupled Aquaponics Using Brackish Water, Salma Walid Hany Ahmed Abdelfattah

Theses and Dissertations

As the world moves to more sustainable agriculture methods in the agribusiness industry, decoupled aquaponics is recognized as one of the newest techniques currently being utilized to achieve more local food security. As the topic is still freshly new within the industry, a finite number of publications and studies have been made that address the topic hands-on with its many variables. Subsequently, in this paper, an experiment was conducted to assess the most optimized production conditions of both lacinato kale (Brassica oleracea var.palmifolia) and Swiss chard Bright Light (Beta vulgaris ssp. Cicla var. flavescens) plants through the utilization of a …

User Profiling Through Zero-Permission Sensors And Machine Learning, Ahmed Elhussiny

Theses and Dissertations

With the rise of mobile and pervasive computing, users are often ingesting content on the go. Services are constantly competing for attention in a very crowded field. It is only logical that users would allot their attention to the services that are most likely to adapt to their needs and interests. This matter becomes trivial when users create accounts and explicitly inform the services of their demographics and interests. Unfortunately, due to privacy and security concerns, and due to the fast nature of computing today, users see the registration process as an unnecessary hurdle to bypass, effectively refusing to provide …

A Novel Approach Using Integrated Greywater Treatment System Applying Net Zero Wastewater Concept For Sustainable Urban Communities, Mianda Khattab

Theses and Dissertations

We are blessed with endless resources that are naturally existing in our world and we fully rely-on without envisioning the bigger picture of what would happen if these resources came to an end, or how can we even ensure sustainable lives by regenerating or reusing or utilizing the naturally existing resources? The surrounding ecosystem, the land we live on, the air we breathe, the water we drink and use for cooking, laundry, shower, irrigation, and many other usages are examples of the resources that we, as global users, are taking for granted.

It is a common knowledge that we are …

Global Health Governance And Its Role In Health Equity: The Case Of Covid-19, Wafa Abu El Kheir-Mataria

Theses and Dissertations

In the globalized world, we are living in, health became the joint responsibility of individuals, their governments, and the global health governance system. Moreover, based on the right to health, health equity is increasingly in demand, and adopting it to a global level has become an even more complex task to realize. This thesis is focuses on health equity at a global level. The main research questions addressed are: Is health equity present at an intercountry /global level? how is it related to Global Health Governance (GHG)? Is GHG performing well in achieving health equity? what are the reasons behind …

Atomistic Assessment Of Drug-Phospholipid Interactions Consequent To Cancer Treatment: A Study Of Anthracycline Cardiotoxicity, Yara Elsayed Ahmed

Theses and Dissertations

Despite being one of the most effective chemotherapeutic agents developed to date, Anthracyclines are notorious for their cardiotoxicity. Their clinical use is frequently limited both in dosage and in prescription due to the severe cardiac damage they cause. The mechanism of anthracycline-induced cardiotoxicity is not yet fully understood. However, it is hypothesized that interactions with the myocardial membrane play an important role in imparting cardiotoxicity. In this study, we use molecular dynamics simulations and density functional theory calculations to study the anthracycline drug molecules and the interactions that they have with the myocardial membrane. We construct a myocardial membrane model …

Metaproteomics Profiling Of Gut Microbiota In Pediatric Acute Lymphoblastic Leukemia Patients, Shahd Ezz El Din

Theses and Dissertations

The gut microbiota is the collection of microorganisms that harbor the human gastrointestinal tract. The relation of microbiota and cancer is an emerging field as several studies have linked the gut microbiota to cancer. Such findings opened the door towards a new era of studies aiming to reveal the role of the microbiota in cancer initiation and progression. Although several metagenomic studies have provided insights into the gut microbial composition in health and diseased state, the microbial functional characteristics is still poorly understood. With current advances in mass spectrometry, comprehensive understanding of microbiota proteome became possible. In this vein, the …

Assessing The Correlation Between The Socioeconomic Level And Cognitive Function Among Older Adults In Egypt, Macy Abougabal

Theses and Dissertations

The number of older adults is increasing worldwide at an unprecedented rate. Some countries began to understand the challenges of aging, while others are still at the stage of comprehending the true dimensions of the situation. There is a global focus on aging research to appropriately mitigate the negative impact of aging and cognitive decline. Not only that dementia add economic pressure on governments, it also increase the psychological and physical burden of the caregivers. Scholars have previously studied socioeconomic level in three variables, namely work, education, and income, and their relationship with cognitive function. It was concluded that the …

Association Of Gut Microbiota Composition With Alzheimer’S-Like Disease In A Rat Model, Hana Heiba

Theses and Dissertations

With many countries turning ‘grey’ and facing an issue with aging populations, the risk of developing one form of neurodegenerative disease is increasing. Dementia, being the most common syndrome resulting from neurodegeneration, severely affects memory and cognitive functions. Alzheimer’s disease (AD) is the most common neurodegenerative disorder, with an estimated 615,000 new cases will be added to the existing 5.7 million by 2030 (Alkasir et al., 2017).

In the current study, we establish a sporadic AD-like rat model by injecting STZ intracerebrally. Stool samples were collected at two time points; after three weeks for the acute stage, and 3 months …

The Impact Of Slavery And Colonialism On The Black Consciousness: Narrative Of The Life Of Frederick Douglass, The Confessions Of Nat Turner, And Incidents In The Life Of A Slave Girl, Mariam Badawi

Theses and Dissertations

According to the German author, essayist, and empirical psychologist Karl Philipp Moritz, to be able to analyze someone psychologically, we have to be able to analyze ourselves as one would know oneself better than one would know anyone else. Therefore, he proposed the study of autobiographies to be able to delve into a writer's "innermost soul"; through their knowledge of themselves" (qtd. in Schlumbohm 32). Moreover, "the psychological effect that the ideology of white supremacy and European imperialism, in the form of slavery and colonialism, has had on Africa and her people has never been fully addressed and understood" (Nobles …

The Death And Rebirth Of The Feminine Muse: Edgar Allan Poe And Sylvia Plath, Noha Ibrahim

Theses and Dissertations

While drawing on mythology and a literary history that associated women with death as well as creativity, Edgar Allan Poe and Sylvia Plath experimented with binary oppositions such as masculine/feminine, composition/decomposition, and death/(re)birth. They gained inspiration from the same source, the dead muse, but how do they transform traditions that derive from classical and medieval literary precedent, perhaps in ways that are inherently critical of patriarchal modes of gender dynamics? Why is Poe fixated on a feminine dead muse while Plath is inspired by what she calls her “father-sea-god muse”? How do both authors represent the female body, and how …

A Qualitative Exploration Of Food Literacy In International Schools In Egypt, Amy Pugsley

Theses and Dissertations

Food literacy is an essential part of good physical and psychological health, however, food literacy is not a mandatory part of K-12 education in all schools. Many factors can influence food literacy levels including familial culture, socioeconomic status, and education levels. This research seeks to examine perceptions of food literacy in high school students and educators at two private American international schools located in Cairo, Egypt. Through the use of observations and interviews, the researcher used a qualitative approach to understand the self-perceptions of food literacy in students studying the American curriculum. The study revealed that students from high-socio-economic backgrounds …

Building Envelope Retrofits For Achieving Thermal Comfort In Naturally Ventilated Buildings In Future Climates: A Case Study Of Social Housing In Egypt, Donna Nader Kamel Ebeid

Theses and Dissertations

Envelope thermal insulation has a significant impact on a scale from global to individual interest. It contributes to indoor thermal comfort, provides economic benefit through reduced electricity bills, increases energy efficiency of buildings through reduced energy consumption, and protects against the change in Earth’s climate through reduced greenhouse gas emissions. In 2021, building operations accounted for 30% of global energy consumption, 27% of annual global CO₂ emissions and 35% of building energy use accounted for electricity consumption which is used to create comfortable indoor living conditions. In Egypt, electricity consumption in residential sector has been steadily increasing, among other …

Evaluation Of Green Roof Technology In Egypt, Hend Abada

Theses and Dissertations

A green roof is a well-known technology worldwide that provides many social, economic, and environmental benefits. In Egypt, green roofs are still a new construction practice where most stakeholders lack business and technical expertise within this emerging industry. This research is concerned with assessing this emerging technology within its contemporary context, Egypt, and testing its feasibility within the physical condition of the Egyptian buildings and the social and economic conditions of the Egyptians. This study starts by presenting intensive information about green roof technology and reviewing the literature on green roofs within the Egyptian context. A grounded methodology is used …

Embodying Abortion: Approaches To Sexual And Reproductive Experiences Of The Cairene Youth., Ruth Morales Cosano

Theses and Dissertations

Whilst abortion in Egypt has been sorely neglected in academic literature, and highly criminalized by state institutions, women in Egypt have by no means ceased to perform it and, what is more, upon reasons that exceed any institutional or legal reasoning. The thesis stems from the need to give voice and continuity to the experiences of women who abort in Cairo. Given the almost complete lack of material showcasing this reality, this research project investigates the meaning-making process of abortion among Cairo's middle and upper classes. Understanding this construction requires studying abortion in its embeddedness in the material, social, and …

The Egyptian Private-Climate Nexus: Private Sector Perceptions On The Green Transition, Yehia Shaheen

Theses and Dissertations

The issue of climate change poses the most pressing threat for humanity. This is especially the case amongst developing countries who, while emitting the minority of global emissions, are forecast to bear the most damage. Such is the case with Egypt, who suffers from marked water scarcity and is vulnerable to climate change driven detriments across a number of levels. As climate finance and private sector investments are key towards the green transition; transitioning to a green economy to fight the adverse impacts of climate change, this thesis aims to analyze the perceptions of private sector actors on the issue …

Chemical And Polymer Characterization Of The Potential Modes Of Degradation Of An Injectable Nucleus Pulposus Replacement Device, Antonio G. Abbondandolo

Theses and Dissertations

HYDRAFIL™ is a poly(vinyl alcohol)/poly(ethylene glycol)-based hydrogel nucleus pulposus replacement device that is injected in situ and has demonstrated efficacy in lowering the prevalence and pain associated with back. In this work, we developed a method to analyze HYDRAFIL™ polymer composition using (TGA) and characterized intermolecular bonding interactions within the hydrogel through (FTIR). To function as a permanent implant for nucleus pulposus replacement, HYDRAFIL™ must be stable when exposed to a multitude of degradation pathways, namely, thermal, chemical, and mechanical. We subjected HYDRAFIL™ to accelerated thermal and chemical degradation pathways and described compositional, physical and chemical property changes using a …

Mutations In Lamin And How It Causes Multiple Tissue-Specific Disorders, Bismark Acquah

Theses and Dissertations

Lamins are the major components of the nuclear lamina where they provide a platform for the binding of proteins to the chromatin and confer mechanical stability (Dittmer and Misteli.,2011). Mutations in the human LMNA gene result in at least 15 distinct disorders ranging from muscular dystrophies to neurological disorders to lipodystrophies (Vytopil et al.,2003). Interestingly, some mutant forms of lamin protein aggregate, which may be toxic to the cells. However, it is unknown how specific mutations in lamin give rise to tissue-specific disease. I hypothesize that certain tissues are susceptible to specific lamin mutations due to the inability of tissue-specific …

Characterizing The Role Of P38kb And Gars In Charcot-Marie-Tooth Disease, Piotr Stan Klos

Theses and Dissertations

Charcot-Marie-Tooth Disease (CMT) is a progressive neuropathology caused by the deterioration of neuronal function of the peripheral motor and sensory nervous systems. Motor symptoms include tripping, ankle twisting, and clumsiness, while sensory symptoms include sensations such as pins and needles and burning pain. Though mutations in a variety of genes can give rise to CMT, several of the genes are tRNA-synthetases. We have recently found that the p38 MAPK (p38Kb), a kinase involved in aging and age-dependent locomotor deficits, regulates the levels of several tRNA-synthetase proteins during aging. p38Kb interacts with the Chaperone-Assisted Selective Autophagy (CASA) complex to mediate the …

Design And Implementation Of Electromagnetic Actuation System To Actuate Micro/Nanorobots In Viscous Environment, Mostafa Abdelaziz

Theses and Dissertations

The navigation of Micro/Nanorobots (MNRs) with the ability to track a selected trajectory accurately holds significant promise for different applications in biomedicine, providing methods for diagnoses and treatments inside the human body. The critical challenge is ensuring that the required power can be generated within the MNR. Furthermore, ensuring that it is feasible for the robot to travel inside the human body with the necessary power availability. Currently, MNRs are widely driven either by exogenous power sources (light energy, magnetic fields, electric fields, acoustics fields, etc.) or by endogenous energy sources, such as chemical interaction energy. Various driving techniques have …

The Target Model For Genealogical Networks, Kolton Baldwin

Theses and Dissertations

Several large-scale projects including FamilySearch, Ancestry, BALSAC (University of Quebec), and others have gathered incredible amounts of genealogical data ranging from millions to billions of individuals. To study the structure of this data, we propose a model that generates a genealogical network based on real-world genealogical data using two key features: (i) geodesic distance between couples prior to union and (ii) the number of children per couple. The distribution of the distance to a couples' nearest common ancestor in an observed community captures the global scale at which biological cycles form in the underlying genealogical network. Similarly, the number of …

Improving Restoration Success Of Winterfat: Influences Of Hydrophobic Seed Coatings And Planting Depth On Seedling Emergence, Kyle Andrew Cook

Theses and Dissertations

In western North America, winterfat (Krascheninnikovia lanata (Pursh) A. Meeuse & Smit) is a valuable protein-rich subshrub whose restoration has been limited by poor seed flowability and low rates of seedling establishment. Seed flowability can be limited by a dense covering of hairs on winterfat fruits that can cause them to clog in mechanized equipment. Seedling establishment can be limited by premature germination of fall-sown seeds that can cause over-winter seedling mortality from freezing, pathogen attack, and winter drought. Seed coatings may provide a way to overcome both of these barriers to winterfat restoration. Coatings can compress hairs against the …

Evaluating The Feasibility Of Bioenergy Production From Single And Mixed Beverage Waste And Sewage Sludge Through An Integrated Hydrothermal Liquefaction-Anaerobic Digestion System, Oluwayinka Michael Adedeji

Theses and Dissertations

Beverage waste and sewage sludge are two of the most generated waste-based biomasses. Recent interest in the hydrothermal liquefaction (HTL) of these wastes pointed to the generation of a byproduct of high dissolved organic carbon [also called aqueous co-product (ACP)]. However, ACP is being discarded which not only increases the environmental footprints of the HTL process but also results in reduced bioenergy potential. Hence, anaerobic digestion (AD) is touted as an effective utilization process of ACP for further bioenergy recovery. This study evaluated the feasibility of producing bioenergy (biocrude and biomethane) from the combination of beverage waste and sewage sludge …

Experimental Evolution Under Varying Sex Ratio And Behavioral Plasticity In Response To Perceived Competitive Environment Independently Influence Male Cricket Calling Effort, Jack Thomas Mckermitt

Theses and Dissertations

The operational sex ratio (OSR) is a key component influencing the magnitude of sexual selection driving the evolution of male sexual traits, but males often also retain the ability to plastically modulate trait expression depending on the current environment. Here we employed an experimental evolution approach to determine whether the OSR affects the evolution of male calling effort in decorated crickets, a costly sexual trait, and whether plasticity in calling effort is altered by the OSR under which males have evolved. Calling effort of males from two selection regimes maintained at different OSRs over 18-20 generations (male- versus female-biased) was …