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The Origins, Evolution, And Phylogeny Of The Praying Mantises (Dictyoptera: Mantodea), Gavin John Svenson

Theses and Dissertations

The relatively small insect order Mantodea (praying mantises) is comprised of approximately 2,366 described species distributed in 436 genera. Members of the group occupy diverse habitats and are distributed across the globe, though their greatest numbers and diversity are concentrated primarily in the tropics. Though continental endemism is common, many groups have a broad global distribution. An immense diversity of morphology is exhibited across the order with adult mantises ranging in size from 2cm to ~25cm, and appearing like a dead leaf, a piece of quartz rock, or a blade of grass. The diversification and specialization of mantises in ecologically …

Protein Coevolution And Coadaptation In The Vertebrate Bc1 Complex, Kimberly Kay Baer

Theses and Dissertations

The cytochrome bc1 complex of the mitochondrial electron transport chain accomplishes the enzymatic reaction known as the modified Q-cycle. In the Q-cycle the bc1 complex transports protons from the matrix to the intermembrane space of the mitochondria, creating the proton gradient used to make ATP. The energy to move these protons is obtained by shuttling electrons from the coenzyme ubiquinol (QH2) to coenzyme ubiquinone (Q) and the mobile cytochrome c. This well studied complex is ideal for examining molecular adaptation because it consists of ten different subunits, it functions as a dimer, and it includes at least five different active …

Characterization Of A Novel Nuclear Variant Of Bmp2 And Coordinate Regulation Of Col11a2 And Col27a1 By The Transcription Factor Lc-Maf, Jaime Lynn Mayo

Theses and Dissertations

ABSTRACT I CHARACTERIZATION OF A NOVEL NUCLEAR VARIANT OF BMP2

Bone morphogenetic protein 2 (Bmp2) is a signaling protein that was first detected by its ability to induce cartilage and bone formation. It has since been implicated in broad variety of developmental, patterning, and disease processes. To date, Bmp2 has only been known to function as an extracellular signaling molecule. However, we have obtained clear evidence for a nuclear form of Bmp2. This nuclear variant, nBmp2, contains a bipartite NLS that overlaps the site of proteolytic cleavage. The NLS remains intact and functional when translation of Bmp2 initiates from a …

Regulation Of Adrenal Steroidogenesis By Interleukin-6, Stephen A. Mcilmoil

Theses and Dissertations

Cortisol and dehydroepiandrosterone (DHEA) are steroids produced by the zona fasciculata (ZF) and reticularis (ZR), respectively, of the adrenal cortex. Both steroids are upregulated in response to adrenocorticotropic hormone (ACTH). Cortisol is a glucorticoid that is important in the regulation of inflammation and metabolism. DHEA is an adrenal androgen important in fetal growth and puberty but tends to decrease gradually after puberty in both men and women. DHEA has various effects on metabolism and immune function including inhibiting the effects of cortisol on some tissues. During the acute phase of stress, cortisol and DHEA rise due to an increase in …

Bioassessment And The Partitioning Of Community Composition And Diversity Across Spatial Scales In Wetlands Of The Bonneville Basin, Mary Jane Keleher

Theses and Dissertations

The Bonneville Basin encompasses an area that was covered by ancient Lake Bonneville and which today lies within the Great Basin province. The Bonneville Basin is distinguished geologically by its characteristic parallel north-south mountain ranges that are separated by broad, alluviated desert basins and valleys. Benches and other shoreline features of ancient Lake Bonneville prominently mark the steep, gravelly slopes of these ranges. Numerous artesian desert springs are present at the base of the mountains and in the valley floors that form various sizes of both isolated wetlands and wetland complexes. Many these wetlands are some of the most unique …

Development And Characterization Of Microsatellite Markers For The Grain Amaranths (Amaranthus Spp. L.), Melanie Ann Mallory

Theses and Dissertations

The grain amaranths (Amaranthus hypochondriacus L., A. cruentus L., and A. caudatus L.) are important pseudocereals native to the Americas that have received increased attention for their nutritional content, specifically their balance of amino acids. The objective of this project was to produce and characterize a set of highly informative, reproducible microsatellite markers for the grain amaranths. A total of 1457 clones were sequenced from three genomic libraries enriched for the microsatellite motifs AAC, AAT and AC. Of these, 353 (24%) contained unique microsatellites. An additional 29 microsatellite loci were identified among 728 BAC-end sequences of a newly developed amaranth …

The Prolamins Of Pearl Millet, Christian B. Ricks

Theses and Dissertations

Although work on the prolamins of pearl millet (Pennisetum glaucum) has revealed partial amino acid sequences for several alcohol-soluble storage proteins (Marcellino et al. 2002) the genes encoding them have not yet been isolated. We constructed a cDNA library from developing P. glaucum seed tissue and screened it using maize zein gene probes to isolate several α-prolamin-like gene sequences. The proteins encoded by these genes generally fall into two size classes: 20.6kD and 27.1kD, which we call the 21kD and 27kD pennisetins. Both proteins are similar in composition and sequence to α-prolamins from maize, sorghum and Coix. Protein bodies that …

Regulation Of Lkb1-Strad-Mo25 Complex Expression And Activation Of Ampk In Skeletal Muscle By Thyroid Hormone, Devon Jack Branvold

Theses and Dissertations

AMP-activated protein kinase (AMPK), a heterotrimeric protein which serves as a metabolic master switch in skeletal muscle, is a research target for the pharmaceutical treatment and prevention of type 2 diabetes. The expression of all of the isoforms of the subunits of AMPK and AMPK activity are increased in skeletal muscle tissue of hyperthyroid rats. Activity of AMPK is regulated by an upstream kinase (AMPKK). The LKB1-STRAD-MO25 complex is a major AMPKK in skeletal muscle. This experiment was designed to determine whether the increase in AMPK activity is accompanied by a thyroid hormone-induced increase in the expression of the LKB1-STRAD-MO25 …

Synthesis And Antiviral Evaluation Of Some 3'-Carboxymethyl-3'-Deoxyadenosine Derivatives, Houguang Shi

Theses and Dissertations

3'-Carboxymethyl-3'-deoxyadenosine derivatives were prepared from 2'-O-TBDMS-3'-deoxy-3'-[(ethoxycarbonyl)methyl]adenosine (1) via simple and efficient procedures. Conversion of 1 to 5'-azido-2'-O-TBDMS-3', 5'-dideoxy -3'-[(ethoxycarbonyl) methyl] adenosine (4) was accomplished via a novel one-pot method employing 5'-activation (TosCl) followed by efficient nucleophilic displacement with tetramethylguanidinium azide. Compound 4 was converted to a 5'-[(N-methylcarbamoyl)amino] derivative (5) via one-pot reduction/acylation employing H2/Pd-C followed by treatment with p-nitrophenyl N-methylcarbamate. The latter step of this two-step process required an efficient source of p-nitrophenyl N-methylcarbamate, thus a highly efficient new method for preparing p-nitrophenyl N-alkylcarbamate was developed. N6-phenylcarbamoyl groups were introduced by treatment with phenylisocyanate, and an efficient new method for …

Development Of Deployable Wings For Small Unmanned Aerial Vehicles Using Compliant Mechanisms, Steven D. Landon

Theses and Dissertations

Unmanned Air Vehicles (UAVs) have recently gained attention due to their increased ability to perform sophisticated missions with less cost and/or risk than their manned counterparts. This thesis develops approaches to the use of compliant mechanisms in the design of deployable wings for small UAVs. Although deployable wings with rigid-link mechanisms have been used in the past to maintain flight endurance while minimizing required storage volume, compliant mechanisms offer many advantages in manufacturability and potential space savings due to function sharing of components. A number of compliant, deployable wing concepts are generated and a classification system for them is formed. …

Sensitivity To Distributional Assumptions In Estimation Of The Odp Thresholding Function, Wendy Jill Bunn

Theses and Dissertations

Recent technological advances in fields like medicine and genomics have produced high-dimensional data sets and a challenge to correctly interpret experimental results. The Optimal Discovery Procedure (ODP) (Storey 2005) builds on the framework of Neyman-Pearson hypothesis testing to optimally test thousands of hypotheses simultaneously. The method relies on the assumption of normally distributed data; however, many applications of this method will violate this assumption. This thesis investigates the sensitivity of this method to detection of significant but nonnormal data. Overall, estimation of the ODP with the method described in this thesis is satisfactory, except when the nonnormal alternative distribution has …

Rotorcraft Smoothing Via Linear Time Periodic Methods, Christopher S. Schulz

Theses and Dissertations

This research presents the development of an on line linear time periodic rotor vibration controller. The Cramer-Rao bound is developed for a linear time periodic system in order to identify the quality of identified system parameters, which are used in system models for controller development. The methods developed in this work allow model parameters can be verified for accuracy and likewise adjusted to improve controller accuracy.

How Can Learning Centers Be Used To Support Classroom Instruction And Promote Critical Thinking In A Kindergarten Classroom?, Amelia M. Pellegrino

Theses and Dissertations

The purpose of this study was to examine how learning centers can be used in the Kindergarten classroom to support regular classroom instruction and encourage students to think critically. This qualitative study used observations, interviews, surveys, student work samples, photographs, and discussions to collect information about the effectiveness of learning centers in the classroom. Sixteen Kindergarten students participated in learning center activities planned and implemented by the researcher to examine how the learning centers related the curriculum and whether the activities encouraged students to think critically about the content. The researcher found that the Kindergarten students showed improvement in their …

Creating And Implementing An Effective Behavior Management Strategy In A Second Grade Classroom, Kristen M. Geary

Theses and Dissertations

The purpose of this study is to ascertain the effectiveness of creating and implementing a self-management behavior system in a second grade classroom. Different types of behavior management were researched through journals discussing behavior management as well as interviews with classroom teachers. Self-management was determined to be a successful behavior management system and was thus chosen to be implemented in this classroom. An additional goal of this study is also to contribute more knowledge to the field of self-management research. This thesis will combine research, student and teacher questionnaires, focus group interviews and a classroom journal in order to determine …

Selective Extraction Of Colorful Proteins Using Reverse Micelles, Loren E. Connell

Theses and Dissertations

Biotechnology is an ever expanding field of science. As the field has expanded, research into bioseparation processes has also expanded. The need for more cost effective ways to deliver products that are in high demand is greater now than ever. Bioseparation processes are a very costly part of the overall process of product development. While traditional separation process are effective, there is promise in many new techniques being developed which have the potential to lower the costs of bioseparations.

The continuous separation method of liquid-liquid extraction using reverse micelles is one such technique. While this technique has been researched in …

C-Reactive Protein Levels According To Physical Activity And Body Weight For Participants In The Coronary Health Improvement Project, Michael T. Massey

Theses and Dissertations

Objectives. Evaluate C-reactive protein (CRP) levels according to weight and physical activity. The study explored how changes in CRP were associated with baseline CRP, weight, and physical activity and changes in these variables.

Methods. A randomized controlled study design assigned 348 individuals to the intervention or control group with measurements taken at baseline, 6 weeks, and 6 months of body weight, physical activity, and serum CRP levels. Participants attended an intensive 40-hour educational course delivered over a four-week period.

Results. At baseline, CRP was negatively associated with total steps/week, and positively associated with weight, BMI, percent fat, and saturated fat …

Real-Time Gps-Alternative Navigation Using Commodity Hardware, Jordon L. Fletcher

Theses and Dissertations

Modern navigation systems can use the Global Positioning System (GPS) to accurately determine position with precision in some cases bordering on millimeters. Unfortunately, GPS technology is susceptible to jamming, interception, and unavailability indoors or underground. There are several navigation techniques that can be used to navigate during times of GPS unavailability, but there are very few that result in GPS-level precision. One method of achieving high precision navigation without GPS is to fuse data obtained from multiple sensors. This thesis explores the fusion of imaging and inertial sensors and implements them in a real-time system that mimics human navigation. In …

Aerobic Biodegradation Of Fuel Oxygenates, Adam M. Gutshall

Theses and Dissertations

Methyl tert-Butyl Ether (MTBE) is the most commonly used fuel oxygenate in the world. Its recalcitrant nature as well as its chemical properties have led to widespread groundwater contamination. Questions regarding its toxicity have spurred a search for viable oxygenate alternatives. Since biodegradability is a key indicator of a chemical’s environmental impact, this research used three different well-known methods, BOD₅, respirometry, and GC analysis, to examine the extent and rates of aerobic biodegradation of MTBE along with tert-butyl alcohol (TBA). The common fuel component toluene was added to some of the samples to determine if the presence of …

A Small-Scale 3d Imaging Platform For Algorithm Performance Evaluation, Steven A. James

Theses and Dissertations

In recent years, world events have expedited the need for the design and application of rapidly deployable airborne surveillance systems in urban environments. Fast and effective use of the surveillance images requires accurate modeling of the terrain being surveyed. The process of accurately modeling buildings, landmarks, or other items of interest on the surface of the earth, within a short lead time, has proven to be a challenging task. One approach of high importance for countering this challenge and accurately reconstructing 3D objects is through the employment of airborne 3D image acquisition platforms. While developments in this arena have significantly …

Development Of Cursor-On-Target Control For Semi-Autonomous Unmanned Aircraft Systems, Joshua D. Crouse

Theses and Dissertations

The research presented in this thesis focuses on developing, demonstrating, and evaluating the concept of a Cursor-on-Target control system for semi-autonomous unmanned aircraft systems. The Department of Defense has mapped out a strategy in which unmanned aircraft systems will increasingly replace piloted aircraft. During most phases of flight autonomous unmanned aircraft control reduces operator workload, however, real-time information exchange often requires an operator to relay decision changes to the unmanned aircraft. The goal of this research is to develop a preliminary Cursor-on-Target control system to enable the operator to guide the unmanned aircraft with minimal workload during high task phases …

Patterns Of User Activity In The Blackboard Course Management System Across All Courses In The 2004-2005 Academic Year At Brigham Young University, Michael E. Griffiths

Theses and Dissertations

The following report discusses the use of the Blackboard Course Management in terms of overall patterns of activity as recorded in the Blackboard activity database across the whole campus of Brigham Young University during the 2004-2005 academic year. The report contains a set of data represented by tables and graphs that summarize activity, or clicks, in the Blackboard system performed by students, professors, and assistants. The clicks are summarized according to a number of different categories and criteria and analyzed to show interesting patterns of activity. The report is designed to show a general campus wide summary of Blackboard activity …

Parallel Fast Multipole Method For Molecular Dynamics, Reid G. Ormseth

Theses and Dissertations

We report on a parallel version of the Fast Multipole Method (FMM) implemented in the classical molecular dynamics code, NAMD (Not Another Molecular Dynamics program). This novel implementation of FMM aims to minimize interprocessor communication through the modification of the FMM grid to match the hybrid force and spatial decomposition scheme already present in NAMD. This new implementation has the benefit of replacing all-to-all communications broadcasts with direct communications between nearest neighbors. This results in a significant reduction in the amount of communication compared to earlier attempts to integrate FMM into common molecular dynamics programs. The early performance of FMM …

Mechanisms Causing Ferric Staining In The Secondary Water System Of Brigham City, Utah, Robert Derring Wallace

Theses and Dissertations

Water from Mantua reservoir has, during some years, exhibited reddish-brown staining when used by Brigham City for irrigation. I propose that seasonal fluctuations in the reservoir chemistry create an environment conducive to dissolving iron from the iron-rich sediments, which subsequently precipitate during irrigation, resulting in a staining event. These conditions are produced by chemical and biological decomposition of organic matter, coupled with isolation of the hypolimnetic waters, which results in seasonal low concentrations of dissolved oxygen in these waters. Under these specific circumstances, anaerobic conditions develop creating a geochemical environment that causes iron and manganese reduction from Fe(III) to Fe(II) …

Pharmacokinetics Of Ultrasonically-Released, Micelle-Encapsulated Doxorubicin In The Rat Model And Its Effect On Tumor Growth, Bryant J. Staples

Theses and Dissertations

Chemotherapy is one of the most successful cancer treatments used today. Unfortunately, the amount of chemotherapy a patient can receive is limited by the associated negative side effects, such as cardiotoxicity, immune system suppression, and nephrotoxicity. Encapsulation of these drugs, Doxorubicin (DOX) in particular, in stabilized Pluronic micelles (Plurogel TM) shows success in limiting these harmful side effects. In previous studies, low-frequency ultrasound (US) has been shown, in vitro, to locally release DOX from these micelles. In this study, a novel drug delivery system involving the encapsulation of DOX in Plurogel and the release of the drug at the tumor …

Asymmetric Dihydroxylation And Aziridination Of Allenes And Related Chemistry, Renmao Liu

Theses and Dissertations

A novel method for asymmetric synthesis of α-hydroxy ketone with excellent regio- and stereoselectivity has been established by the systematic investigation of asymmetric dihydroxylation of allenes. The efficiency of kinetic resolution of racemic allenes was also investigated by using the AD reaction on both 1,3-disubstituted and trisubstituted allenes. Steric effects, electronic effects and allene substitution are also discussed. Aziridines were formed by copper-catalyzed intramolecular nitrene addition to alkenes. The carbamate group was used as the tether between the alkene and the nitrene. Subsequent nucleophilic attack of the aziridine was accomplished using RSH, R2NH, N3-,or ROH as the nucleophile. This addition …

The Development Of The Remarital Assessment Questionnaire For Divorced Persons (Raq-D), Derrel Jay Higgins

Theses and Dissertations

The development of the Remarital Assessment Questionnaire for Divorced Persons (RAQ-D) is presented. Steps of development of the questionnaire are outlined: a review of remarital literature, interviews with remarried couples, the creation of a pool of items, review of the items by clinicians, and the development of a preliminary questionnaire. Data were collected through the internet. An Exploratory Factor Analysis of the data yielded scales relating to adjustment areas that are specific to remarital couples. The resulting scales exhibited acceptable level of internal consistency. Psychometric properties of the resulting scales are reported. Implications and recommendations of further development of the …

Investigation Of The Iron Oxidation Kinetics In Mantua Reservoir, Scott H. Lathen

Theses and Dissertations

Irrigation of the municipal cemetery in Brigham City, Utah resulted in stained headstones in 2001 and 2002. The water used in the irrigation came from Mantua reservoir, a medium sized impoundment situated near the mouth of Box Elder Canyon. In order for Brigham City to establish a city wide secondary pressurized irrigation system using water from Mantua reservoir, the cause and the source of staining problem must be determined. Previous research (Wallace 2006) determined that the source of the staining was the reduction of iron found in Mantua Reservoir sediments that occurred when seasonal variations in the reservoir caused anaerobic …

Towards Early State Disease Detection In Microdevices: Fabrication And Testing Of Micro Total Analysis Systems For Bioanalytical Applications, Tao Pan

Theses and Dissertations

The past few years have seen a rapid expansion in interest in the characterization of the entire complement of proteins, or proteome. Micro total analysis systems (μTAS) are an emerging promising method, offering rapid, sensitive and low sample consumption separations. I have demonstrated microchip capillary electrophoresis (CE) devices made of CaF2. New methods have been developed for micromachining enclosed capillaries in CaF2. CE analysis of fluorescently labeled amino acids was used to illustrate bioanalytical applications of these microdevices. Initial on-chip infrared spectroscopy results for qualitative analyte identification were achieved in microfluidic CaF2 channels. I have also shown the evaluation of …

Gas Hydrate Formation In Gulf Of Mexico Sediments, Jennifer L. Dearman

Theses and Dissertations

Gas hydrate formation was studied in Gulf of Mexico (GOM) sediments. Sediments studied were from six-meter long cores from Mississippi Canyon Block 118 and a 27-meter core from a cruise in 2002 of the Marion Dufresne. These sediments retained their in situ seawater before testing. Hydrate formation rate and induction times were measured. The hydrate memory effect was studied in GOM sediments with and without in situ seawater. Hydrate induction time was short when in situ seawater was present. Bioproducts adsorbed on particles in the sediments are postulated to shorten the induction times by maintaining seawater structuring around coated particles. …

Analysis Of Breast Lesions Using A Simplified Rubber Band Straightening Transform And The Onion Transform, Matthew Allen Lee

Theses and Dissertations

This thesis compares different methods that could be used to construct a computer aided diagnosis (CAD) system that analyzes mammograms. Such systems have many steps, but this thesis focuses on feature extraction, feature selection, and classification. The main comparison is between the simplified Rubber Band Straightening Transform (SRBST) and the Onion Transform, which are used to extract texture features. Another comparison is between 2D and 3D co-occurrence matrices. Next, features are selected using a greedy algorithm. This section mainly compares the effectiveness of Receiver Operating Characteristic (ROC) and Class Overlap Rating (COR). Also evaluated are the effectiveness of Linear Discriminate …