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Articles 14371 - 14400 of 19641
Full-Text Articles in Entire DC Network
Synthesis Of Glycolipids And Evaluation Of Their Nkt Cell Stimulatory Properties, Yang Liu
Synthesis Of Glycolipids And Evaluation Of Their Nkt Cell Stimulatory Properties, Yang Liu
Theses and Dissertations
Natural killer T (NKT) cells are a subset of T cells that modify a variety of immune responses. NKT cells recognize glycolipid antigen presented by a molecule called CD1d, a nonclassical antigen-presenting molecule. The best known subset of CD1d-dependent NKT cells expresses an invariant T cell receptor Vα (TCR-α) chain. These are referred to as type I or invariant NKT (iNKT) cells. When stimulated by a glycolipid, NKT cells rapidly release large amounts of cytokines. Cytokines released by NKT cells can induce either Th1 or Th2 responses. Th1 cytokines are effective in regulating bacterial, parasitic, and viral infections. But Th1 …
State Regulation Of Assisted Reproductive Technology, Jonathan J. Morgan
State Regulation Of Assisted Reproductive Technology, Jonathan J. Morgan
Theses and Dissertations
State regulation of assisted reproductive technology (ART) has been occurring since the inception of earlier technological advances such as artificial insemination to aid human reproduction. I provide a brief overview of the current regulation of ART in the U.S. and the literature on state regulation. Unlike previous studies of ART regulation which use content analysis or case studies of individual state laws I estimate ART regulation for the entire U.S. by using a series of random effects logistic regression models for the time period 1995-2006. To my knowledge this is the first quantitative analysis of ART regulation. I test the …
Developmental Contributions To Variation In Aspen Clones And The Influence Of Pre-Fire Succession Status On Aspen Regeneration Success, Eric A. Smith
Developmental Contributions To Variation In Aspen Clones And The Influence Of Pre-Fire Succession Status On Aspen Regeneration Success, Eric A. Smith
Theses and Dissertations
This thesis includes two studies: The first examined developmental changes that take place in the physiology of aspen (Populus tremuloides Michx.) and to characterize developmental influences on patterns of phenotypic trait variation among different aged ramets within the aspen clones. We surveyed eight clones, each with 8 distinct age classes ranging from 1 to 170 yrs in age. Using regression analysis we examined the relationships between ramet age and expression of functional phenotypes. Eight of the phenotypic traits demonstrated a non-linear relationship in which large changes in phenotype occurred in the early stages of ramet development and stabilized thereafter. …
The Effects Of Low Frequency Ultrasound In Transdermal Drug Delivery, Aaron M. Wells
The Effects Of Low Frequency Ultrasound In Transdermal Drug Delivery, Aaron M. Wells
Theses and Dissertations
Objective: Determine if varying ultrasound frequency affects the delivery of 10% hydrocortisone concentrations during phonophoresis. Utilize intramuscular microdialysis probe for drug collection, thus improving the experimental model. Methods: Thirty one (10 in groups 1 and 2, 11 in group 3) healthy subjects participated in this study. Interventions: Subjects were randomly assigned to one of three treatment groups receiving 10 minute ultrasound treatments applied to a standardized area of the gastrocnemius muscle of the right leg. The ultrasound was performed over the treated area using a 10% hydrocortisone compound mixed with standard ultrasound gel. The contralateral limb served as the control …
The Effects Of Indoor Track Curve Radius On Sprint Speed And Ground Reaction Forces, Jesse Tipasa Tukuafu
The Effects Of Indoor Track Curve Radius On Sprint Speed And Ground Reaction Forces, Jesse Tipasa Tukuafu
Theses and Dissertations
Sprinting on a curve is significantly slower than on a straightaway. Although the dimensions vary from track to track, indoor track curves are among the tightest curves that athletes will sprint at maximal speed. Previous studies have provided theories for how speed attenuation occurs when running on a curve. Yet, no previous research has determined how the variability of indoor track curve radii affects trained sprinters at maximal speeds. Purpose: To determine the differences in running speeds, ground time (GT), and medio-lateral (ML) impulse, with different indoor track radii. A secondary purpose was to understand the between-leg differences in GT …
Development And Use Of A Physiologically Based Mathematical Model Describing The Relationships And Contributions Of Macronutrients To Weight And Body Composition Changes, Saori Sakita
Theses and Dissertations
The effect of the dietary macronutrient composition on weight loss has been a controversial issue for decades. During that time, a high-protein, high-fat, and low-carbohydrate diet has been one of the more popular weight loss diets with the public. We hypothesized that a computer simulation model using STELLA software could help to better understanding the effect of the dietary macronutrient composition on weight loss. We calculated daily total oxidation instead of total energy expenditure as others have done based on the facts that carbohydrate, fat, and protein intake influence carbohydrate, fat, and protein oxidation. In order to create a simple …
Modeling, Design, And Testing Of Contact-Aided Compliant Mechanisms In Spinal Arthroplasty, Peter Andrew Halverson
Modeling, Design, And Testing Of Contact-Aided Compliant Mechanisms In Spinal Arthroplasty, Peter Andrew Halverson
Theses and Dissertations
Injury, instrumentation, or surgery may change the functional biomechanics of the spine. Spinal fusion, the current surgical treatment of choice, stabilizes the spine by rigid fixation, reducing spinal mobility at the cost of increased stress at adjacent levels. Recently, alternatives to spinal fusion have been investigated. One such alternative is total disc replacements. The current generation of total disc replacements (TDRs) focuses on restoring the quantity of motion. Recent studies indicate that the moment-rotation response and axis of rotation, or quality of motion (QOM), may have important implications in the health of adjacent segments as well as the health of …
Shavian Self-Fashioning: Authorized Biography And Shaw's Superman, Cort H. Kirksey
Shavian Self-Fashioning: Authorized Biography And Shaw's Superman, Cort H. Kirksey
Theses and Dissertations
George Bernard Shaw exercised an above-average level of authorial control, which even extended to his relationship with his biographers. Shaw crafts a persona, with the help of his "authorized" biographer Archibald Henderson, which displays a process of evolutionary development and progress along the lines of the Shavian philosophy of the Life Force and the Superman. In essence, Shaw is casting himself as a prototype for the Superman through the autobiographical manipulation of his biographers and aesthetic modes of self-fashioning.
The Relationship Between Identity Development And Family History Knowledge, Clive Gordon Haydon
The Relationship Between Identity Development And Family History Knowledge, Clive Gordon Haydon
Theses and Dissertations
The primary purpose of this study was to examine the relationship between identity development in late adolescent university students and family history knowledge. The relationship was examined within both the individual developmental and family systems theoretical frameworks. It was proposed that identity development involves achieving personal autonomy from the family of origin and at the same time maintaining positive relatedness to the family of origin. Identity development was examined using exploration, commitment, autonomy, and relatedness as dependent variables. It was proposed that late adolescent's personal exploration of and commitment to roles and values may be influenced by knowledge of parent …
The Relationship Between Attachment Related Family-Of-Origin Experiences And Sexual Satisfaction In Married Couples, James G. Strait
The Relationship Between Attachment Related Family-Of-Origin Experiences And Sexual Satisfaction In Married Couples, James G. Strait
Theses and Dissertations
This study of married couples examined the relationship between perceptions of attachment related family-of-origin experiences and sexual satisfaction directly and when mediated by marital quality. The sample consisted of 3,953 married couples who responded to the RELATionship Evaluation (RELATE). The nested model showed that more positive overall family-of-origin experiences and parent-child relationships were related to higher sexual satisfaction. When adding marital quality as a mediator, overall family-of-origin experience and the parent-child relationship were predictive of higher sexual satisfaction when mediated by marital quality but removed most direct effects to sexual satisfaction. There was a strong positive relationship between marital quality …
Crosses, Flowers, And Toads: Classic Maya Bloodletting Iconography In Yaxchilan Lintels 24, 25, And 26, Kirsten Rachelle Steiger
Crosses, Flowers, And Toads: Classic Maya Bloodletting Iconography In Yaxchilan Lintels 24, 25, And 26, Kirsten Rachelle Steiger
Theses and Dissertations
The lintels of Yaxchilan Structure 23 seem to be a demonstrable case wherein specific symbols are singled out and deliberately used in an ordered sequence. Taken together as a unified series, Yaxchilan Lintels 24, 25, and 26 summarize the multi-step process of royal autosacrifice. An iconographic study of the huipil patterns depicted on these lintels yields a better understanding of complex bloodletting iconography and the way in which depictions of ceremonial autosacrifice reinforce Classic Maya beliefs relating to the divine role of Maya elite in eliciting communion with the gods and the subsequent rebirth of the cosmos. The rich iconography …
The Relationship Of Equal Division Of Labor And Satisfaction Of Division Of Labor To Positive Parenting As Mediated By Parents' Relationship Quality, Lauren Alyssa Bone Barnes
The Relationship Of Equal Division Of Labor And Satisfaction Of Division Of Labor To Positive Parenting As Mediated By Parents' Relationship Quality, Lauren Alyssa Bone Barnes
Theses and Dissertations
Couples learn to negotiate a complex intersection between household labor and family processes. Using both observational coding and questionnaire self report, this study examined the relationship between father and mothers' reported equality with their division-of-labor, their satisfaction with division-of-labor and their respective positive parenting as observed in taped interaction with a target child while controlling for quality of the relationship between the parents. Findings showed that egalitarian division of labor was positively related to satisfaction in division of labor and that egalitarian division of labor was a significant predictor of mothers' relationship quality, but not fathers' relationship quality. It also …
Chronic Amp-Activated Protein Kinase Activation And A High-Fat Diet Have An Additive Effect On Mitochondria In Rat Skeletal Muscle, Natasha Fillmore
Chronic Amp-Activated Protein Kinase Activation And A High-Fat Diet Have An Additive Effect On Mitochondria In Rat Skeletal Muscle, Natasha Fillmore
Theses and Dissertations
Factors that stimulate mitochondrial biogenesis in skeletal muscle include AMPK, calcium, and circulating FFAs. Chronic treatment with either AICAR, a chemical activator of AMPK, or increasing circulating FFAs with a high fat diet increases mitochondria in rat skeletal muscle. The purpose of this study was to determine whether the combination of chronic chemical activation of AMPK and high fat feeding would have an additive effect on skeletal muscle mitochondria levels. We treated Wistar male rats with a high fat diet (HF), AICAR injections (AICAR), or a high fat diet and AICAR injections (HF+AICAR) for six weeks. At the end of …
Assessing Traditional Morphology- And Chemistry-Based Species Circumspections In Lichenized Ascomycetes: Character Evolution And Molecular Species Delimitation In Common Western North American Lichens, Steven Leavitt
Theses and Dissertations
Accurate species delimitation has critical implications for ecological and conservation studies; and for understanding factors driving diversification. However, a growing body of evidence indicates that morphology-based species circumspection in lichenized ascomycetes often fails to accurately represent the number of fungal species. The use of molecular data in lichen systematics provides an important alternative to traditional morphological characters for identifying natural groups and assessing evolutionary histories in challenging lichen taxa. In this work, I examined two common lichen-forming genera in western North America, Rhizoplaca and Xanthoparmelia, as models for investigating character evolution, species delimitation in morphologically and chemically diverse species, …
Anti-Depressive And Anti-Obesity Changes Following Either Dietary Isoflavone Treatment Or Injection Treatment With The Isoflavonoid Equol: Positive Response Dependent On Animal Age And Ovarian Status In Female Long Evans Rats, Crystal Blake
Theses and Dissertations
Two conditions associated with ovarian depletion are increased potential for depressive episodes and increased abdominal weight gain. In five different experiments we examined the effect of soy-containing diets or equol injections on depression, serotonin levels, weight gain (BW) and white adipose tissue (WAT) deposition of female Long-Evans rats in various stages of life. Rats were intact, ovariectomized or experienced natural ovarian failure (NOF). While this paper will present each experiment, only experiment 5 is outlined here due to space limitations. From conception the rats were exposed to either a soy-rich (Phyto-600) or low-soy diet (Phyto-low). Animals experienced NOF at approximately …
Landscape-Scale And Macrohabitat-Scale Variation In Growth And Survival Of Young June Sucker (Chasmistes Liorus) In Utah Lake, Joshua Daniel Kreitzer
Landscape-Scale And Macrohabitat-Scale Variation In Growth And Survival Of Young June Sucker (Chasmistes Liorus) In Utah Lake, Joshua Daniel Kreitzer
Theses and Dissertations
The spatial scales at which ecological phenomena are viewed constrain the results of interactions between species and their environments. In lake ecosystems, important dynamics have been identified at the landscape scale and the macrohabitat scale. To determine if landscape-scale effects and macrohabitat-scale effects are important in survival and growth of young June suckers, we compared variation among sites in Utah Lake. Large semi-permeable cages were used to house June suckers in situ at five sites representing landscape-scale variation and two sites representing macrohabitat-scale variation in Utah Lake. We compared survival and growth among sites and related it to resource availability …
Emotional Intimacy, Coparenting, And Family Work: A Latent Class Growth Analysis, Adam Michael Galovan
Emotional Intimacy, Coparenting, And Family Work: A Latent Class Growth Analysis, Adam Michael Galovan
Theses and Dissertations
From a family systems theoretical view, this paper uses both variable-oriented and person-oriented research approaches to examine parental marriage as a dynamic, interdependent system, and extends the literature by examining parental marriage across a 15 year time span. Employing latent growth curve analysis of 490 mother-father dyads from the NICHD Study of Early Child Care and Youth Development, this study considers multiple aspects of the relationship husbands and wives have together as spouses (emotional intimacy), parents (ideas about discipline and a child-centered vs. adult-centered orientation to childrearing), coparents (agreement regarding parenting beliefs and discipline), and household managers (agreement on the …
Regional Heterogeneity And Diversity Of Astrocytes In Response To Hiv-1 Proteins And Morphine, Wen Chen
Regional Heterogeneity And Diversity Of Astrocytes In Response To Hiv-1 Proteins And Morphine, Wen Chen
Theses and Dissertations
HIV-infected individuals who abuse opiates have been found to have a higher incidence and a faster progression of HIV encephalitis. Astrocytes, the major support cells in the CNS, are known to play a critical role in the HIV neuropathy. Although astrocytes tend not to be productively infected by the HIV-1 virus, dysregulation of their pro- and anti- inflammatory cytokines/chemokines secretion is usually neurotoxic. Glutamate transport in astrocytes is reported to be impaired as well, which result in extrasynaptic excitatory neurotransmitter accumulation and over stimulation of postsynaptic neurons. It is long known that astrocytes from different brain regions have diverse responses …
An Inferential Framework For Network Hypothesis Tests: With Applications To Biological Networks, Phillip Yates
An Inferential Framework For Network Hypothesis Tests: With Applications To Biological Networks, Phillip Yates
Theses and Dissertations
The analysis of weighted co-expression gene sets is gaining momentum in systems biology. In addition to substantial research directed toward inferring co-expression networks on the basis of microarray/high-throughput sequencing data, inferential methods are being developed to compare gene networks across one or more phenotypes. Common gene set hypothesis testing procedures are mostly confined to comparing average gene/node transcription levels between one or more groups and make limited use of additional network features, e.g., edges induced by significant partial correlations. Ignoring the gene set architecture disregards relevant network topological comparisons and can result in familiar n<
Mechanistic Studies On The Electrochemistry Of Proton Coupled Electron Transfer And The Influence Of Hydrogen Bonding, Timothy Alligrant
Mechanistic Studies On The Electrochemistry Of Proton Coupled Electron Transfer And The Influence Of Hydrogen Bonding, Timothy Alligrant
Theses and Dissertations
This research has investigated proton-coupled electron transfer (PCET) of quinone/hydroquinone and other simple organic PCET species for the purpose of furthering the knowledge of the thermodynamic and kinetic effects due to reduction and oxidation of such systems. Each of these systems were studied involving the addition of various acid/base chemistries to influence the thermodynamics and kinetics upon electron transfer. It is the expectation that the advancement of the knowledge of acid/base catalysis in electrochemistry gleaned from these studies might be applied in fuel cell research, chemical synthesis, the study of enzymes within biological systems or to simply advance the knowledge …
Chemopreventive Effects Of Dietary Selenium And Soy Isoflavones In A Mouse Model Of Prostate Cancer, Trevor Elisha Quiner
Chemopreventive Effects Of Dietary Selenium And Soy Isoflavones In A Mouse Model Of Prostate Cancer, Trevor Elisha Quiner
Theses and Dissertations
Prostate cancer is the most commonly diagnosed non-skin cancer in men and the second leading cause of cancer death in the United States. Prostate cancer, like many cancers, is a disease that generally requires a long period of time to develop and grow before it becomes detectable. This long period of latency makes prostate cancer a candidate for dietary chemoprevention. Soy and selenium (Se), are associated with a decreased risk of prostate cancer. We previously showed that high dietary intake of selenium (Se) and soy isoflavones decreased the expression of the androgen receptor (AR) and AR-regulated genes in the prostates …
Liver Kinase B1/Amp-Activated Protein Kinase Signaling In The Diaphragm, Jacob D. Brown
Liver Kinase B1/Amp-Activated Protein Kinase Signaling In The Diaphragm, Jacob D. Brown
Theses and Dissertations
The Liver Kinase B1 (LKB1)/AMP-Activated Protein Kinase (AMPK) signaling pathway is a major regulator of skeletal muscle metabolic processes. During exercise, LKB1-mediated phosphorylation of AMPK leads to its activation, promoting mitochondrial biogenesis and glucose transport, among other effects. The roles of LKB1 and AMPK have not been fully characterized in the diaphragm. Two methods of AMPK activation were used to characterize LKB1/AMPK signaling in diaphragms from muscle-specific LKB1 knockout (KO) and littermate control (C) mice: (1) acute injection of 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) and (2) 5-min direct electrical stimulation (ES) of the diaphragm. Diaphragms were excised 60 minutes post-AICAR injection and …
Children Adopted Internationally Examining Developmental Status At Arrival And Six Month Follow Up, Ann Mccormick
Children Adopted Internationally Examining Developmental Status At Arrival And Six Month Follow Up, Ann Mccormick
Theses and Dissertations
In the past 5 years, almost 100,000 children have been internationally adopted. Research suggests that many of these children have growth and developmental delays, but few large scale studies have been completed. In the current study data obtained from a restrospective chart review of 534 children followed in the International Adoption Clinic at Cincinnati Children’s Hospital Medical Center between 1999 and 2007 was analyzed. Prevalence of developmental delays and sensory processing issues initially and after 6 months in country, the relationship of delays/issues with previously identified risk factors, and the frequency of recommendations for early intervention (EI) and therapy services …
The Structure And Stability Of Alpha-Helical, Orthogonal-Bundle Proteins On Surfaces, Shuai Wei
The Structure And Stability Of Alpha-Helical, Orthogonal-Bundle Proteins On Surfaces, Shuai Wei
Theses and Dissertations
The interaction of proteins with surfaces is a major problem involved in protein microarrays. Understanding protein/surface interactions is key to improving the performance of protein microarrays, but current understanding of the behavior of proteins on surfaces is lacking. Prevailing theories on the subject, which suggest that proteins should be stabilized when tethered to surfaces, do not explain the experimentally observed fact that proteins are often denatured on surfaces. In an attempt to develop some predictive capabilities with respect to protein/surface interactions, it was asked in previous works if the stabilization/destabilization of proteins on surfaces could be correlated to secondary structure …
Early Adolescents' Forgiveness Of Parents: An Analysis Of Determinants, Katherine Janet Christensen
Early Adolescents' Forgiveness Of Parents: An Analysis Of Determinants, Katherine Janet Christensen
Theses and Dissertations
The current study examined forgiveness within the parent-adolescent relationship. Theoretical foundations and definitions of forgiveness were examined, after which a relational approach to forgiveness was explored. The direct influences of the quality of mother- and father-child relationships (parent and observed reports) and modeled marital forgiveness on early adolescents' forgiveness toward both mothers and fathers (child report) were examined; the mediating roles of parent forgiveness of child and adolescent social-cognitive skills (empathy and emotional regulation) were also analyzed. Mother, father, and child self-reported questionnaires and in-home observational data were taken from Time 1 and Time 3 (two years later) of the …
Piezoresistive Nano-Composites: Characterization And Applications, Thomas B. Hyatt
Piezoresistive Nano-Composites: Characterization And Applications, Thomas B. Hyatt
Theses and Dissertations
Innovative multifunctional materials are essential to many new sensor applications. Piezoresistive nano-composites make up a promising class of such materials that have the potential to provide a measurable response to strain over a much wider range than typical strain gages. Commercial strain gages are currently dominated by metallic sensors with a useable range of a few percent strain at most. There are, however, many applications that would benefit from a reliable wide-range sensor. These might include the study of explosive behavior, instrumentation of flexible components, motion detection for compliant mechanisms and hinges, human-technology interfaces, and a wide variety of bio-mechanical …
The Prevalence Of Maxillary Altered Passive Eruption In A Dental School Population., Francisco Carlos
The Prevalence Of Maxillary Altered Passive Eruption In A Dental School Population., Francisco Carlos
Theses and Dissertations
AIM: The aim of this investigation is to determine the prevalence of maxillary altered passive eruption in a dental school population. METHODS: 100 subjects were examined clinically and had models fabricated of their maxilla. Demographic, periodontal, cast measurements were recorded for each subject. Demographic variables recorded included age, gender, and ethnicity, history of orthodontic treatment, presence of incisal /occlusal wear, appearance of gingival excess, and presence of gingival asymmetry. Measurements made on cast included clinical crown length, clinical crown width, papillary height, and distance from the lateral gingival zenith to the gingival aesthetic line. Clinical crown width-to-length ratio was calculated. …
Perception Of Soft Tissue Laser Use In Orthodontic Practice: A Survey Of Orthodontists, Periodontists, And General Dentists, Brandon Burke
Perception Of Soft Tissue Laser Use In Orthodontic Practice: A Survey Of Orthodontists, Periodontists, And General Dentists, Brandon Burke
Theses and Dissertations
Recently, soft tissue lasers have been introduced into orthodontic practice to perform procedures that were traditionally referred to other dental professionals. The purpose of this study was to compare the attitudes of orthodontists, periodontists, and general dentists regarding the use of soft tissue lasers by orthodontists. The ultimate goal was to facilitate communication among dental professionals and improve the care of orthodontic patients requiring management of soft tissues. A survey was developed to evaluate and compare the current opinions of orthodontists (n=330), periodontists (n=171), and general dentists (n=77) regarding orthodontists’ use of soft tissue lasers. When compared to orthodontists and …
Students' Perceptions Of Their Esl Training In Preparation For University Reading Tasks, Olha Kondiyenko
Students' Perceptions Of Their Esl Training In Preparation For University Reading Tasks, Olha Kondiyenko
Theses and Dissertations
This study sought to determine perceptions of former English Language Center (ELC) students of their readiness for university reading tasks after completing their ESL training. Former ELC students who now study or have studied at 10 different American post-secondary institutions provided insights for the study. Through questionnaires and face-to-face interviews, the study collected and analyzed many interesting and revealing comments from participants. Their comments demonstrated that even though the majority of students overall were satisfied with their learning experiences at the ELC, some significant changes still have to be made to be able to fully meet students' educational needs. Participants …
Targeting Complex Cyclic Peptides For Synthesis: The Celogentin And Theonellamide Families, Joshua Wayne Robinson
Targeting Complex Cyclic Peptides For Synthesis: The Celogentin And Theonellamide Families, Joshua Wayne Robinson
Theses and Dissertations
Celogentin C and theonellamide F are a class of natural products that have potential antimitotic behavior. They both contain interesting bicyclic structures with unusual linkages within a central moiety. Celogentin C's highly functionalized tryptophan moiety has two unusual linkages, a β-substituted Leu connection to the C6 of the indole structure that makes up the left-hand ring, and a τ-N connection of the imidazole to the C2 of the indole constructing the right-hand ring. This right-hand ring connection was solved via a novel oxidative coupling procedure developed in our group and the left-hand ring was initially constructed via a radical conjugated …