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Articles 14101 - 14130 of 19641
Full-Text Articles in Entire DC Network
Simple Rules Leaders Use To Guide Their Organizations During Times Of Rapid Change, Kristine Quade
Simple Rules Leaders Use To Guide Their Organizations During Times Of Rapid Change, Kristine Quade
Theses and Dissertations
Few leaders would refer to their organization as a complex adaptive system (CAS)--one that is irreversible and unpredictable. They might say their organization contains diverse elements and is constantly learning--the other two aspects of a CAS. Few top leaders rarely are able to identify the self-organizing patterns as they emerge. This study involved 58 senior leaders in five 5 market sectors who were guiding their organizations during times of rapid change. Using a Delphi method, the intent was to identify what simple rules the leaders used to shape the speed, direction and outcomes of self-organizing patterns. A simple rule expands …
Examining The Occurrence Of Verbal And Non-Verbal Positive Emotional Expression During Discussion Of Interpersonal Trauma In Psychotherapy: A Case Study, Whitney A. Dicterow
Examining The Occurrence Of Verbal And Non-Verbal Positive Emotional Expression During Discussion Of Interpersonal Trauma In Psychotherapy: A Case Study, Whitney A. Dicterow
Theses and Dissertations
Recent theories of positive emotion, including the broaden and build theory, propose that positive emotion can broaden one's range of thoughts and actions and build long-lasting personal resources (Folkman & Moskowitz, 2000; Fredrickson & Levenson, 1998). However, little research exists on how positive emotion is expressed in the context of discussing interpersonal trauma in psychotherapy. The current study explored the expression of positive emotion during discussions of interpersonal trauma over the course of an individual case of psychotherapy as related to the broaden and build theory. The client-participant in this single-case study was a 28-year-old African American female who presented …
M-Learning: An Exploration Of The Attitudes And Perceptions Of High School Students Versus Teachers Regarding The Current And Future Use Of Mobile Devices For Learning, Jason Messinger
Theses and Dissertations
Despite rapid growth and use of mobile Internet devices, schools have remained resistant to the adoption of the devices. The cost of the devices, the distractibility of the devices to the learning environment, and safety and privacy issues that come with the devices are all reasons that schools have used against the implementation of the devices. Nevertheless, studies have shown that students become more motivated when technology and social media are allowed for their learning (Kozma, 2005). To better understand the usage gap, teachers and students at a high school underwent an online survey and follow up focus group. The …
A Phenomenological Study Of Competing Priorities And African American Women Striving To Achieve Work-Life Balance, Gayle Colston Barge
A Phenomenological Study Of Competing Priorities And African American Women Striving To Achieve Work-Life Balance, Gayle Colston Barge
Theses and Dissertations
Organizations must address a myriad of issues from diversity initiatives to ensuring that work-life programs are responsive to the needs of its fastest growing segment--women of color of which African American women are the largest minority group. Despite the significance of their presence, research to date on the topic of work-life balance and family issues is based primarily on the experiences of middle-class white women. All women struggle with issues related to work-life conflict. Missing from this dialogue are the voices of African American women. Despite evidence that work is a significant domain in their lives, researchers have limited information …
Leading A Successful Change Effort At The School Level, Sindy Samantha Shell
Leading A Successful Change Effort At The School Level, Sindy Samantha Shell
Theses and Dissertations
Schools that have implemented professional learning communities (PLCs) have been experiencing the initial intention of professional learning communities, however, the essence of shared leadership, using collaboration as a problem solving component, and data-driven decision making is not in fact what is taking place in schools. The term "PLC" has become an overused and often detrimental label. This observed outcome could be attributed to how the professional learning community is implemented in the school. In order to have the change be effective, the new endeavor must be anchored in the culture. In fact, it has been observed that missing component in …
African American Males Diagnosed With Schizophrenia: A Phenomenological Study, Lorraine Anderson
African American Males Diagnosed With Schizophrenia: A Phenomenological Study, Lorraine Anderson
Theses and Dissertations
Abstract Little is known about how African American men with schizophrenia experience their every day existence. Through applying interpretive phenomenology and using a methodological structure designed by van Manen (1990, 1997), this research aimed to enrich the understanding of living with schizophrenia for these African American males. In this study, five men ranging in age from 21 to 57 described their lives within the context of existing with the diagnosis of schizophrenia. The lived experiences across the interviews revealed four overarching themes: They know that they are mentally ill; they make a special effort to test reality; they assert their …
Novel Role Of Mecp2 In Developing Oligodendrocytes And Myelination, Daniel Moore
Novel Role Of Mecp2 In Developing Oligodendrocytes And Myelination, Daniel Moore
Theses and Dissertations
Methyl-CpG-binding protein 2 (MeCP2 is) is an epigenetic regulator that binds to methylated DNA. Initially identified as transcriptional repressor, MeCP2 also binds to different proteins functioning as gene activator. Importantly, MecCP2 gene mutations and changes in MeCP2 levels are associated to several forms of mental retardation and autism-related disorders; including Rett, a neurodevelopmental disorder affecting primarily girls. While brain MeCP2 was considered to be exclusively neuronal, this regulator is also present in glia. We found that oligodendrocytes, the myelinating cells of the central nervous system (CNS), express particularly high MeCP2 levels at a developmental stage that precedes their final maturation. …
Examination Of Gene Flow In Populations Of Gypsy Moth, Lymantria Dispar Dispar (Lepidoptera: Noctuidae: Lymantriinae), Nirosha K. Ranawaka
Examination Of Gene Flow In Populations Of Gypsy Moth, Lymantria Dispar Dispar (Lepidoptera: Noctuidae: Lymantriinae), Nirosha K. Ranawaka
Theses and Dissertations
No abstract provided.
An Approach To The Synthesis Of Plakortethers A-E, Duminda Shiromalee Liyanage
An Approach To The Synthesis Of Plakortethers A-E, Duminda Shiromalee Liyanage
Theses and Dissertations
No abstract provided.
Comparing The Emotional Intelligence, Personal Traits, And Work Impacts Of Performing Versus High-Performing Middle Managers, Teresa Lara
Theses and Dissertations
The study of emotional intelligence (EI) has grown in popularity over recent decades. Some authors have argued that EI results in heightened personal and professional success. Middle managers, in particular, are believed to require EI, as they are tasked with linking and coordinating the strategic and operational levels of the organization. Having EI is believed to help middle managers develop relationships; influence others and garner their support; create harmony among stakeholders; and communicate, collaborate with, and lead others. All of these activities require understanding and managing others, their needs, and their emotions--in short, all of these activities require EI. However, …
Schizophrenia, Acculturation, And Chinese American Families : A Review And Clinical Recommendations For Treatment, Lorena Ho
Theses and Dissertations
Schizophrenia is a disorder that appears across cultures, typically creating a tremendous amount of suffering and loss for both the individual diagnosed, and his or her family. While psychosocial family treatment (along with medication) has proved thus far to be the most promising treatment for schizophrenia in Western cultures, it has yet to be proven effective with ethnocultural minority groups. Furthermore, literature shows that Western treatments for schizophrenia cannot be uniformly applied to ethnocultural minority groups with the expectation of similar results. In the United States, Asian Americans, and specifically Chinese Americans, continue to underutilize mental health services for schizophrenia, …
How Husbands Can Support Their Wives In Achieving Weight Management Goals: The Development Of A Self-Help Resource, Christi Lynn Kush
How Husbands Can Support Their Wives In Achieving Weight Management Goals: The Development Of A Self-Help Resource, Christi Lynn Kush
Theses and Dissertations
The nationwide prevalence of obesity calls for more effective strategies for weight loss and maintenance of desired weight. The majority of weight loss programs focus on behavior change (diet and exercise) with some success, although lost weight is often regained. Interventions that boost the long-term effects of weight loss achievements are greatly needed. Marriage provides an ideal context for the lifestyle changes required for effective weight maintenance. Although well-intentioned, spouses may not know how to support their partner's weight loss efforts. Because women are more likely than men to attend to their spouses' health needs and women struggle more than …
Cultivating 21st Century Competencies In A Virtual Worlds Learning Environment, Terry K. Smith
Cultivating 21st Century Competencies In A Virtual Worlds Learning Environment, Terry K. Smith
Theses and Dissertations
Education reforms in recent years have pressured schools to show achievement results through testing and conformity to standards. Problems of low student engagement in the current test-heavy environment have been a serious barrier to learning in schools across the United States, especially in low socioeconomic areas. After years of unsuccessful testing programs, educators and researchers are calling for approaches that enhance student engagement and foster the 21st century competencies that students need to succeed. Researchers have found that engagement, 21st century competencies, and learning can be enhanced using virtual worlds approaches (Arici, 2008; Barab, Dodge, & Ingram-Goble, 2006; Dede, Nelson, …
Optimized Torque Pulse For Motion Production, Jared A. Johnson
Optimized Torque Pulse For Motion Production, Jared A. Johnson
Theses and Dissertations
No abstract provided.
Assessment Of Potential Sediment And Nutrient Loading From Rural/Agricultural To Urban Land Use Transition On The English Coulee, Grand Forks, Nd, Rhonda L. Olson
Assessment Of Potential Sediment And Nutrient Loading From Rural/Agricultural To Urban Land Use Transition On The English Coulee, Grand Forks, Nd, Rhonda L. Olson
Theses and Dissertations
No abstract provided.
Juvenile Offenders And Their Victims, Jennifer E. Swetits
Juvenile Offenders And Their Victims, Jennifer E. Swetits
Theses and Dissertations
No abstract provided.
Technical Evaluation Of Sugar Beet Pulp As An Alternative Feedstock For Bioethanol Production, Ebenezer Donkoh
Technical Evaluation Of Sugar Beet Pulp As An Alternative Feedstock For Bioethanol Production, Ebenezer Donkoh
Theses and Dissertations
No abstract provided.
Phenotypic Effects Of Varying The Dosage Of A Chromosome Segments Utilizing Maize B-A Translocations, Dale Cletus Brunelle
Phenotypic Effects Of Varying The Dosage Of A Chromosome Segments Utilizing Maize B-A Translocations, Dale Cletus Brunelle
Theses and Dissertations
No abstract provided.
Head-Start Juvenile And Adult Resident Eastern Box Turtles (Terrapene Carolina Carolina): Winter Ecology Including Microhabitat Selection, Temperature Tolerance And Philopatry, Amberly Moon
Theses and Dissertations
The Eastern box turtle (Terrapene carolina carolina) is one of the most common reptiles in North America, but is soon to be threatened due to increased urbanization, disease, and the pet and food trades. In order to assist resource managers in choosing suitable sites for relocation studies, more information on the winter ecology of this species is necessary. We examined the temperature tolerance, microhabitat and degree of philopatry to hibernacula for juvenile and adult E. box turtles for two consecutive winters in Charles City Co, VA. The turtles were tracked via radio telemetry to record point locations during the active …
Determining Impediments To Gene Flow In A Natural Population Of Cornus Florida L. Cornaceae, Using Integrative Landscape Genetic Techniques, Crystal Meadows
Determining Impediments To Gene Flow In A Natural Population Of Cornus Florida L. Cornaceae, Using Integrative Landscape Genetic Techniques, Crystal Meadows
Theses and Dissertations
This study examined the impact intervening environment has on gene flow in the insect pollinated understory tree, Cornus florida L., by combining GIS and landscape genetic techniques (Least Cost Path Analysis, Circuit Theory, and Conditional Genetic Distance). Traditional population genetic analysis indicated pair-wise relatedness was significantly correlated to distance (Pearson; r = -0.312, P < 0.001) suggesting a spatial component to offspring relatedness. Dispersal throughout the study site was non-random, exhibiting a high degree of pollen pool structure due to restricted gene flow (Two-Generation Analysis; Φft = 0.161, P = 0.001). Forest structure was quantified in GIS layers representing coniferous canopies, mixed hardwood canopies, C. florida canopies, open understory (roads), and open understory/canopy due to tree removal. Of these layers, landscape isolation for the roads layer provided the best-fit model for describing genetic differentiation among sampled pollen pools (Mantel; r = 0.542, P = 0.001). These data also suggest that improved biological inferences can be gained by examining a range of landscape isolation models.
Biochemical Evaluation Of Lignin-Like Molecules, Jay Thakkar
Biochemical Evaluation Of Lignin-Like Molecules, Jay Thakkar
Theses and Dissertations
Current anticoagulants carry a serious risk of bleeding complications. In addition, narrow therapeutic index, drug interactions, immunological reactions, toxicity and high cost to benefit ratio limits the effective use of these drugs in patients with thrombotic conditions.Heparin is the most widely used anticoagulant. We hypothesized that one of the major drawback of heparins, its non-specific interaction with the plasma proteins arises as a result of negative charges. To reduce these non-specific interactions, our laboratory designed sulfated low molecular weight lignin (LMWL) like biomacromolecules, which were found to be direct inhibitors of thrombin and factor Xa, acting through a unique exosite-2 …
The Synthesis, Characterization, And Upconverting Properties Of Erbium Doped; Ytterbium, Erbium Co-Doped Yttrium Oxysulfide Phosphors Under 808, 980, And 1560 Nm Excitation, James Wilkins
Theses and Dissertations
Bulk yttrium oxysulfide phosphors were prepared using the polysulfide flux method. The morphology and structure was characterized using transmission electron microscopy and x-ray powdered diffraction. Visible emissions occurring near 530 and 550 nm and 660 - 670 nm consistent with the 2H11/2, 4S3/2 → 4I15/2 and 4F9/2 → 4I15/2 transitions, respectively, were observed under 808, 980, and 1560 nm excitation. The upconverting mechanisms excited at 808, 980, and 1560 nm have been investigated in detail. The power dependent behavior of the upconverted emission intensities for singly doped erbium phosphors excited at 808 and 980 nm indicated a two-photon excitation process. …
“Clicked” Bivalent Multifunctional Ligands In Alzheimer’S Disease., Ronak Gandhi
“Clicked” Bivalent Multifunctional Ligands In Alzheimer’S Disease., Ronak Gandhi
Theses and Dissertations
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by beta-amyloid (Aβ) aggregation/oligomerization, biometal dyshomeostasis, oxidative stress, and neuroinflammation. The multifactorial nature of AD may indicate the therapeutic potential of multifunctional ligands that tackle various risk factors simultaneously as effective AD-modifying agents. This notion is further supported by the fact that while numerous AD-modifying agents targeting one single risk factor have been developed and a number of them entered clinical trials, none of them has been successfully approved by the FDA. Furthermore, neuronal cell membrane/lipid rafts (CM/LR) have been demonstrated to associate with all the indicated risk factors, indicating that this …
A Study On The Biochemical And Cellular Effects Of Enviormental Tobacco Smoke On Adult And Developing Rat Brain Biochemistry, Brian Fuller
A Study On The Biochemical And Cellular Effects Of Enviormental Tobacco Smoke On Adult And Developing Rat Brain Biochemistry, Brian Fuller
Theses and Dissertations
Exposure to environmental tobacco smoke (ETS) has been recognized as a significant health risk for adults and children. In adults, ETS exposure has been linked to increased incidences of cardiovascular disease and dementia. In children, exposure has been linked to behavioral and cognitive deficits. Studies on the effects of ETS in the brain have been largely epidemiological, and have lacked a defined explanation of the molecular/biochemical effects of ETS. The present dissertation aims to test whether ETS exposure leads to altered biochemistry in the adult and developing mammalian brain. A rat ETS exposure model was employed to investigate changes at …
Renal Epithelial Sodium Channel (Enac) Regulation Of Pregnancy Mediated Hemodynamic Adaptations: Mechanistic Insights, Crystal West
Renal Epithelial Sodium Channel (Enac) Regulation Of Pregnancy Mediated Hemodynamic Adaptations: Mechanistic Insights, Crystal West
Theses and Dissertations
Pregnancy-mediated sodium (Na) retention is required to provide an increase in plasma volume for the growing fetus. The mechanisms responsible for this Na retention are not clear. In the first study, we generated a renal tubule protein profile indicating α ENaC as the only sodium transport protein upregulated in mid and late pregnancy. To determine the in vivo activity of ENaC we conducted in vivo studies in late pregnant rats (day 18-20) and virgin rats to measure the natriuretic response to ENaC blockade (with benzamil). The in vivo activity of ENaC (UNaV post benzamil - UNaV post vehicle) was markedly …
Approaches For Enhancing Therapeutic Efficacy Of A Novel Il-10 Gene Family Member: Mda-7/Il-24, Belal Azab
Approaches For Enhancing Therapeutic Efficacy Of A Novel Il-10 Gene Family Member: Mda-7/Il-24, Belal Azab
Theses and Dissertations
Melanoma differentiation associated gene-7 (mda-7) was discovered in the Fisher laboratory by subtraction hybridization of temporally spaced subtracted cDNA libraries prepared from terminally differentiated human melanoma cells treated with human fibroblast interferon (IFN-β) and the protein kinase C activator mezerein (MEZ), an approach called ‘differentiation induction subtraction hybridization’ (DISH). mda-7 is located in human chromosome 1q32–33 and based on sequence homology, chromosomal localization, and its functional properties, the mda-7 gene is now classified as a member of the IL-10 family of cytokines and named IL-24. The mda-7/IL-24 cDNA encodes a protein of 206-amino acids with a predicted size of ~24-kDa, …
Cyclic-Di-Gmp Signaling In The Borrelia Spirochetes, John Freedman
Cyclic-Di-Gmp Signaling In The Borrelia Spirochetes, John Freedman
Theses and Dissertations
Lyme disease is the most common tick-borne disease in North America, with approximately 35,000 cases reported to the Centers for Disease Control in 2008. The genome of its causative agent, Borrelia burgdorferi, encodes for a set of genes involved in the metabolism and regulatory activities of the second messenger nucleotide, cyclic-di-GMP (c-di-GMP). Rrp1 is a response regulatory-diguanylate cyclase, and its regulatory capability is likely mediated via production of c-di-GMP, as it lacks a DNA-binding domain. One known class of c-di-GMP effector/binding proteins are those that harbor a PIlZ domain. The genome of B. burgdorferi strain 5A4 encodes for one chromosomally-carried …
Functional Consequences Of Cytosine Methylation In Mitochondrial Dna Catalyzed By Dna Methyltransferase 1, Lisa Shock
Functional Consequences Of Cytosine Methylation In Mitochondrial Dna Catalyzed By Dna Methyltransferase 1, Lisa Shock
Theses and Dissertations
Cytosine methylation of mitochondrial DNA (mtDNA) was first described several decades ago, but neither the mechanism generating this modification nor its functional significance was known. Because mitochondrial dysfunction is a hallmark characteristic of numerous human diseases, including neurological and cardiovascular disease, aging and cancer, this dissertation addressed whether epigenetic modification of mtDNA regulates mitochondrial function. We show that mtDNA contains not only 5-methylcytosine (5mC), but also 5-hydroxymethylcytosine (5hmC), suggesting that previous reports likely underestimated the degree of epigenetic modification within the mitochondrial genome. We questioned how these modifications were generated by looking for mitochondrial isoforms of the nuclear-encoded DNA methyltransferases. …
Navigating The Space Of My Body, Ferwa Ibrahim
Navigating The Space Of My Body, Ferwa Ibrahim
Theses and Dissertations
This paper explores my process of orienting myself within spaces and inhabiting them. It focuses on how I use my own body as an instrument for developing a relationship between the two. A ritual is a social conditioning of the body and Authentic Movement is discovering body’s own route. This paper reviews my process of situating myself within a space by using both of them as the language of my body. It also discusses the development of some of my recent work through understanding the language of my own body.
Genetic Manipulation Of The Relapsing Fever Spirochete Borrelia Hermsii Permits Novel Investigation Into The Role Of Factor H Binding In Borrelial Virulence, Lindy Fine
Theses and Dissertations
Borrelia hermsii, an etiologic agent of tick-borne relapsing fever, binds negative complement regulator factor H (FH) via its FhbA protein. Direct demonstration of the role of FhbA in the disease process has been hindered by the lack of genetic manipulation systems for the relapsing fever Borrelia. Here, we demonstrate successful generation of a B. hermsii strain YOR fhbA deletion mutant (Bh YORΔfhbA) that constitutively produces green fluorescent protein (GFP). Genetic manipulation did not affect growth rate or plasmid composition. Bh YORΔfhbA lost factor H-binding and C3b-inactivation capabilities, but retained resistance to killing in human serum and infectivity in mice. Stable …