Digital Commons Network^™

Cytotoxic Properties Of Novel Platinum Compounds, Bbr3610-Dach And Trans-4-Nbd In Tumor Cells: Cellular Effects Of 1, 2-Dach And Nbd Ligands, Vijay Menon

Theses and Dissertations

Platinum-based chemotherapeutics are used for the treatment of a wide range of cancers and a number of attempts have been made toward developing compounds with better cellular stability and similar or enhanced cytotoxicity as compared to their predecessors. The first part of the work reported here focuses on the cellular effects of the metabolically stable dinuclear platinum compound, BBR3610-DACH. Comet assay showed this compound to form interstrand crosslinks, a highly toxic DNA lesion in HCT116 cells, at equimolar concentrations to its parental compound, BBR3610. Cell cycle studies showed that BBR3610-DACH causes G1/S and G2/M cell cycle arrest with S phase …

Inhibition Of Retinoic Acid Receptors Results In Defasciculation Of The Trigeminal Nerve In Xenopus Laevis, Jeremy Thompson

Theses and Dissertations

The anatomy of the cranial peripheral nervous system has been studied for over a century, yet surprisingly little is known about how the nerves are guided to their targets. The study of the development of these nerves has important implications for our understanding of craniofacial anomalies and possible treatments for both injury and genetic disorders of nerve development such as Goldenhar-Gorlin syndrome. We have discovered that retinoic acid (RA) may play a role in the development of the trigeminal nerve. Inhibition of retinoic acid receptors (RAR) results in trigeminal nerves that become unbundled or defasciculated in the eye region. To …

Fragments Of Social Life, Rachel Leah Cohn

Theses and Dissertations

This paper examines selected events from biography and how those events have influenced my philosophies about art-making as well as the work I have produced while a graduate student at Virginia Commonwealth University. This thesis is an attempt to give an expanded context for my work through various lenses, including the personal, the traumatic, the historical and the material.

The Role Of Family Organization In Family Health History Communication About Cancer, Vivian M. Rodríguez

Theses and Dissertations

Family health history (FHH) has been recognized as an important tool in cancer prevention and health promotion. To date, literature on FHH discussions about cancer have largely focused on patient-physician communication or the dissemination of cancer-specific genetic tests results within the family. Fewer studies have sought to identify family factors that may promote FHH discussions, yet this type of information could be used to identify families needing support in having these conversations. Thus, the present study examined relations between family organization (cohesion and flexibility), communication openness, and FHH communication about cancer within a diverse group of women recruited from an …

Naturalis Historia, Reconstructed, Sarah Briland

Theses and Dissertations

When Pliny the Elder wrote Naturalis Historia around 70 A.D., the idea of natural history contained and connected biology, geology, and mineralogy with the history of painting and sculpture. Art was an extension of the natural world as its materials were extracted from plants, animals, and, particularly, mined and quarried pigments, stone, and metals. In my developing body of work, Incidents of Naturalis Historia, Reconstructed, I combine wasps’ nests, architectural fragments, and other found objects excavated from my surrounding environment with elements of glass that resemble lichen, crystallization, and geologic specimens. These works simulate artifacts of an alternative history; one …

The Design And Validation Of A Computational Model Of The Human Wrist Joint, Afsarul Mir

Theses and Dissertations

Advancements in computational capabilities have allowed researchers to turn towards modeling as an efficient tool to replicate and predict outcomes of complex systems. Computational models of the musculoskeletal system have gone through various iterations with early versions employing dramatic simplifications. In this work, a three-dimensional computational model of the wrist joint was developed. It accurately recreated the skeletal structures of the hand and wrist and represented the constraints imposed by soft tissue structures like ligaments, tendons, and other surrounding tissues. It was developed to function as a tool to investigate the biomechanical contributions of structures and the kinematic response of …

Examining The Relations Between The Mental Health And Physical Health Of Caregivers Of Ms In A Mexican Sample, Gillian Leibach

Theses and Dissertations

Evidence suggests that caregiver health affects patient health. Consistent with the Biopsychosocial Model, mental health (anxiety, depression, satisfaction with life, self-esteem), physical health (bodily pain, general health, performance in physical role, physical functioning), burden, and social support were examined in the present study to understand the relations between these variables and the overall health of 81 caregivers of patients with multiple sclerosis (MS) in Mexico. The relation between mental health and physical health was significant. Canonical correlations revealed that depression and general health emerged as primary variables and these were entered into a series of analyses with burden and social …

Sociodemographic Risk Factors Of Glycemic Control For Youth With T1d: Cross-Sectional And Longitudinal Patterns Of Hba1c, Priscilla Powell

Theses and Dissertations

Individual growth curve (IGC) modeling evaluated longitudinal trajectories of glycemic control and diabetes care of youth with Type 1 Diabetes (T1D) over three years. IGC modeling allowed comparison of confounded sociodemographic predictors of disease outcomes that included ethnicity, SES, parent marital status, family structure, as well as disease duration, to determine the relative impact of these factors in the evolution of HbA1c and diabetes care throughout adolescence. At baseline, participants recruited from two pediatric endocrinology clinics included 198 youth, ages 9-15 (M age = 12.65, 77% Caucasian, 74% lived with married biological parents, M SES = 45.70) with average HbA1c …

Development And Evaluation Of The Assessment Of Opioid Taking Behaviors And Adherence Scale (Aotba) In Patients With Sickle Cell Disease, Abdulkhaliq Jassem Alsalman

Theses and Dissertations

The rapid growth in opioid therapy for non-cancer pain has occurred without an adequate appreciation of the consequences of this growth. Few studies provide patient-centered evidence that can be used to inform the current proposed standards for efficacious (safe and effective) opioid prescribing in non-cancer pain. Furthermore, different terms may be used interchangeably in the literature to refer to opioid-taking behaviors, resulting in imprecise or vague interpretation of existing evidence. We therefore sought to explore patterns of opioid-taking behavior and their biopsychosocial-spiritual determinants in African-American adults with sickle cell disease (SCD). Many questions surround opioid use for non-cancer pain, but …

Underlying Conditions, Mariam Eqbal

Theses and Dissertations

The following is a collection of lines, curves, and dots on a plane, representing words fashioned to communicate my ideas about relationships between the thing and the nothing. This thesis is like a map, a contour drawing, an assortment of lines, speaking my thoughts about things in relation to space and time. As something moving, developing into another thing, as a thing sentient, I am viewing, performing, and processing incremental acts. I am looking at water and I can see my reflection break into a thousand pieces. It is like watching time.

Predictors Of Agitation In The Critically Ill, Ruth Burk

Theses and Dissertations

BACKGROUND: Agitation is a common complication in the intensive care unit (ICU) manifested in behavior and actions that range from simple apprehension or anxiety to frankly combative behavior.5 Agitation is associated with significant adverse outcomes.1-3 Studies report up to 71% of ICU patients have some degree of agitation during their ICU stay and that agitation is observed 32% of the time.3;4 Potential causes of agitation in critically ill patients are numerous; however, data about factors that predict agitation are limited. OBJECTIVE: The specific aim of this study was to identify predictors of agitation on admission to the ICU as well …

Finding History In The Future, Al-Sowaidi Aisha

Theses and Dissertations

Change and development over an extremely fast period of time in Qatar have shifted the atmospheric sense of the country. The distance created by the skyscrapers and their scale to people has a great impact on the behavior and interaction between the people and the city. In my research, I aim to incorporate the old experiences and behaviors with contemporary design in objects used within the house to maintain the feeling of being home through reliving the fading behaviors and traditions as well as bringing closer the modern city into the home through the use of materials. Through experimentation with …

Binding Energies And Solvation Of Organic Molecular Ions, Reactions Of Transition Metal Ions With, And Plasma Discharge Ionization Of Molecular Clusters, Isaac Kwame Attah

Theses and Dissertations

In this dissertation, different approaches have been employed to address the quest of understanding the formation and growth mechanisms of carbon-containing molecular ions with relevance to astrochemistry. Ion mobility mass spectrometry and DFT computations were used to investigate how a second nitrogen in the pyrimidine ring will affect the formation of a covalent bond between the benzene radical cation and the neutral pyrimidine molecule, after it was shown that a stable covalent adduct can be formed between benzene radical cation and the neutral pyridine. Evidence for the formation of a more stable covalent adduct between the benzene radical cation and …

Regularities In The Augmentation Of Fractional Factorial Designs, Lisa Kessel

Theses and Dissertations

Two-level factorial experiments are widely used in experimental design because they are simple to construct and interpret while also being efficient. However, full factorial designs for many factors can quickly become inefficient, time consuming, or expensive and therefore fractional factorial designs are sometimes preferable since they provide information on effects of interest and can be performed in fewer experimental runs. The disadvantage of using these designs is that when using fewer experimental runs, information about effects of interest is sometimes lost. Although there are methods for selecting fractional designs so that the number of runs is minimized while the amount …

Reverse-Phase Ion-Pairing Ultra Performance Liquid Chromatography-Mass Spectrometry In Characterization And Fingerprinting Of Diverse Sulfated Glycosaminoglycan Mimetics, Pooja Ponnusamy

Theses and Dissertations

Heparin is a highly sulfated glycosaminoglycan with potent anticoagulant, antimetastatic, and anti-inflammatory effects. Polymeric and polyanionic nature of heparin makes dosing and side effects a nightmare for healthcare professionals. Our laboratory has proposed appropriately designed, small, highly sulfated aromatic molecules as potential mimetics of heparin. These easier-to-synthesize small molecules have been shown to possess interesting pharmacological and improved toxicological profiles. However, the detection and characterization of these highly sulfated molecules is challenging. A robust RP-IP UPLC-MS method was developed to successfully retain, resolve and quantify sulfated non-saccharide GAG mimetics without the requirement of pre- or post- column derivatization. Comparative analysis …

Tissue Engineering Composite Biomimetic Gelatin Sponges For Bone Regeneration, Isaac Rodriguez

Theses and Dissertations

The field of tissue engineering aims to develop viable substitutes with the ability to repair and regenerate the functions of damaged tissue. Common practices to supplement bone regeneration in larger defects include bone graft biomaterials such as autografts, allografts, xenografts, and synthetic biomaterials. Autologous bone grafting is the current gold-standard procedure used to replace missing or damaged bone. However, these grafts have disadvantages such as donor site morbidity, limited availability, and the need for a secondary surgery. The focus of this study is to tissue engineer a lyophilized gelatin composite sponge composed of hydroxyapatite (HA), chitin whiskers (CW), and preparations …

A Comparison Of Rectangular Vs. Circular Radiographic Collimation During Simulated Endodontic Therapy, Tareq Alali

Theses and Dissertations

Rectangular collimation is used in dentistry to reduce radiation by restricting the x-ray beam to approximately the size of a number 2 intraoral film (3.2X4.1 cm). However, this restricted beam size can lead to exposure errors. The aim of this study was to retrospectively evaluate the number of radiographs exposed and the presence of technical errors by the use of traditional circular or rectangular collimators during endodontic therapy on simulated teeth in manikins. A total of 1475 digital radiographs of 84 teeth exposed by 60 dental students were evaluated. Evaluation was done by a board certified endodontist, an endodontic resident, …

Microbial Evaluation Of The Calamus Heated Gutta-Percha Delivery System, Christopher Smart Dds

Theses and Dissertations

If gutta-percha cartridges are contaminated with bacteria prior to obturation then contamination of the root canal system may result. Successful treatment not only depends on bacterial elimination but also depends on prevention of recontamination. This study was motivated by the observation that endodontists frequently use single use gutta-percha cartridges on multiple patients. The goal of this study was to determine if cross contamination occurred when a single gutta-percha cartridge in the Calamus™ Flow System was used on multiple patients. An effective recovery method was established during a pilot study using Enterococcus faecalis as a sample bacterium. Microbial recovery was obtained …

Reproduction And Functional Response Of Cornus Florida Across An Urban Landscape Gradient, Angela Redwine

Theses and Dissertations

Urbanization greatly alters plant and pollinator communities and can affect pollinator movement and subsequent gene flow. Plants persisting in urban areas must adjust to local environmental conditions often different from those in which they naturally evolved, and cultivation techniques for landscaping species have developed traits suitable for existence in urban habitats. Cultivated varieties and native conspecifics often exist in geographic proximity, and if pollinator movement is not blocked by urban structural components, functional differences may negatively impact spatially proximate native populations. I used spatial analysis of successful pollination of Cornus florida to estimate how pollinator movement is affected by urban …

The Development And Applications Of The Hint Scoring Function: Exploring Colchicine-Site Anticancer Agents And Tautomerism, Chenxiao Da

Theses and Dissertations

The overall aim of this work was to apply HINT, an empirical scoring function based on the understanding of hydrophobicity, to analyze and predict the binding affinities and biological activities of colchicine-site anticancer agents. The second, concurrent aim was to improve the scoring function by incorporating tautomerism within the modeling process. Our belief is that proper evaluation of tautomeric forms for small molecules will improve performance of virtual screening. The novel pyrrole-based compounds targeting the colchicine site were docked into the receptor using HINT as a rescoring function. Two distinct binding modes dictated by the size and shape of a …

The Effects Of Sleep Problems And Depression On Alcohol-Related Negative Consequences Among College Students, Mcgann Amanda Wattenmaker

Theses and Dissertations

Previous literature provides an overview of the multiple relationships between alcohol use, protective behavioral strategies (PBS), alcohol-related negative consequences, depression, and sleep problems among college students, as well as differences by individual level characteristics, such as age, gender, and race/ethnicity. Several studies have found that specific demographic groups of students are more likely to reach a higher blood alcohol content (BAC) when “partying” or socializing (Turner, Bauerle, & Shu, 2004; Crotty, 2011). A variety of studies have also confirmed the positive relationship between high blood alcohol content and experiencing alcohol-related negative consequences (Turner, et al., 2004; Martens, Taylor, Damann, Page, …

Analysis Of Contributing Factors To Obesity In Children And Adolescents In Southwest Georgia, Sydney Leigh Worthy

Theses and Dissertations

Today more than 23 million U.S. children and adolescents are either obese or overweight. Hospital costs from obesity-related diseases in youth have increased from $35 million (0.43% of total hospital costs) during 1979 to 1981 to $127 million (1.79% of total costs) during 1997 to 1999. During the Pathway to Med School program, I collaborated with three other students to develop a research project on childhood and adolescent obesity. We conducted surveys at nine different primary care clinics in the southwest Georgia area. Approval was sought by the Institutional Review Board of Phoebe Putney Memorial Health System and Albany Area …

Positive Deviance And Hand Hygiene, In Eui Oh

Theses and Dissertations

Healthcare-associated infections (HAis) are significant problems to our nation since these are n1ajor causes of n1orbidity and mortality and these produce both financial and medical burden. Good hand hygiene is one of the most effective measures for preventing healthcareassociated infections (HAls); however, hand hygiene compliance among healthcare workers is poor. An1ong 1nany strategies to in1prove hand hygiene behavior in healthcare workers, this paper reviews current I iterature on hand hygiene and introduces the Positive Deviance (PD) 1nethod to achieve high hand hygiene compliance and i1nprove hand hygiene behaviors

Existing literatures and guidelines on hand hygiene and PD are synthesized, and …

Female Condoms As A Means To Reduce The Transmission Of Hiv Among Maasai Women, Lisa R. Boeger

Theses and Dissertations

No abstract provided.

A Review Of The Impact Of Obesity On Prostate Cancer Progression And Epigenetic Regulation, Colleen Bratney

Theses and Dissertations

No abstract provided.

Characterization Of Bioreducible Poly(B-Amino Ester) Nanoparticles For Sirna Delivery, Bolivia Hurtado De Mendoza

Theses and Dissertations

Glioblastoma multiforme (GBM) is one of the most malignant brain tumors affecting adults. It is characterized by necrotic tissue and abnormal vasculature, making it highly resistant to current cancer treatments. A promising alternative to standard cancer therapeutics is the use of drug delivery systems such as polymeric nanoparticles (NP) that deliver silencing RNA (siRNA) exclusively to tumor cells for gene knockdown. Presently, nonviral delivery vectors, such as poly(B-amino ester) (PBAE) NP, are beneficial delivery systems because they are less immunogenic and easier to chemically modify than vectors delivered by viruses. Although current formulations of PBAEs allow cargo release via hydrolytic …

Race, Power, And White Womanhood: The Obsessions Of Tom Watson And Thomas Dixon Jr., Tara Nicole Kowasic

Theses and Dissertations

Thomas Dixon Jr. (1864 -1946) and Thomas E. Watson (1856-1922), two controversial and radical figures, are often credited with the second coming of the Ku Klux Klan. Dixon, writer of novels and plays such as The Leopard’s Spots (1902) and The Clansman (1905), and Watson, politician, prolific writer, and publisher of Watson’s Magazine and The Jeffersonian, reached the masses and saturated popular culture with their racial agenda. As each of these men had especially long careers, this thesis focuses on particular times and specific issues. With Dixon, the writing of The Clansman (1905) and production of The Birth of a …

The Impact Of Medicaid Reform On Dental Practice Setting, Barrett W. R. Peters

Theses and Dissertations

Purpose: To assess the impact of dental Medicaid reform in Virginia on dental practice settings (private practice, corporate practice and safety net clinics). Methods: This retrospective cohort study of 16.2 million dental claims is from the Virginia Department of Medical Assistance Services, which included claims for providers participating in Virginia’s Medicaid program during a 10-year period (2002-2012). The dividing date for the reform was July 1, 2005. The outcome measure was mean claims per participating provider. A Poisson regression model was used to predict the mean number of claims per provider with the following predictors: reform period, practice setting, provider …

Atomic And Electronic Structure Of A Ligand-Protected Bimetallic Nanocluster, Ag4ni2(Dmsa)4, Anthony F. Pedicini

Theses and Dissertations

An important direction in nanoscale science is to synthesize materials whereby atomic clusters serve as the building blocks. Properties of these clusters can be controlled through size and composition, and such an approach offers a pathway toward designing larger, customized materials. One way to stabilize such materials is through the use of ligated clusters. Ag4Ni2(DMSA)4 is one such cluster, the first with a bimetallic core, and has been stabilized by the experimental group of A. Sen at The Pennsylvania State University. The theoretical studies undertaken in this thesis were directed toward providing information on the atomic structure, nature of electronic …

Comparison Of Oral Ketamine-Midazolam And Chloral Hydrate-Meperidine-Hydroxyzine Sedation Regimens In Pediatric Dentistry, David Merrell

Theses and Dissertations

Purpose: The purpose of this study was to create an experimental design to compare the regimen of ketamine-midazolam to chloral hydrate-meperidine-hydroxyzine for moderate oral conscious sedation. Methods: Patients between 36 and 83 months of age have been randomly assigned to receive 1 of the 2 regimens. Dosages, times, and vital signs will be recorded. Procedures will be recorded on video for assessment of sedation level and behavior. Patients will be contacted to evaluate postoperative sleeping, discomfort, and amnesia. Data will be analyzed using two-group t-tests (TOST) of equivalence in means to compare the two groups across the study period. Results: …