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A Mathematical System For Human Implantable Wound Model Studies, Salomonsky Paul-Michael
A Mathematical System For Human Implantable Wound Model Studies, Salomonsky Paul-Michael
Theses and Dissertations
Dermal wound healing involves a myriad of highly regulated and sophisticated mechanisms, which are coordinated and carried out via several specialized cell types. The dominant players involved in this process include platelets, neutrophils, macrophages and fibroblasts. These cells play a vital role in the repair of the wound by orchestrating tasks such as forming a fibrin clot to stanch blood flow, removing foreign organisms and cellular debris, depositing new collagen matrix and establishing the contractile forces which eventually bridge the void caused by the initial infraction.\\[5pt] \indent Our current understanding of these mechanisms has been primarily based upon animal models. …
Development Of Pectoral Apparatus In Ictalurid Catfish, Shweta Lahiri
Development Of Pectoral Apparatus In Ictalurid Catfish, Shweta Lahiri
Theses and Dissertations
The thesis contains two manuscripts- 1) Developmental changes in pectoral muscle fiber diameter and number in the Blue Catfish, Ictalurus furcatus and 2) Reduction in pectoral spine and girdle in domesticated Channel Catfish, Ictalurus punctatus is likely caused by the absence of fish predators. The first study showed that fiber diameter increased linearly with fish size, whereas fiber number increases non linearly with fish size in the Blue Catfish correlated with dietary shift. The second study showed shorter spines in domesticated Channel Catfish as compared to wild Channel Catfish was a result of reduction in selection pressure during domestication in …
Environmental Influences On Sex Ratio And Spatial Distribution Of Dioecious Morella Cerifera L. On A Virginia Barrier Island., Molly Hokkanen
Environmental Influences On Sex Ratio And Spatial Distribution Of Dioecious Morella Cerifera L. On A Virginia Barrier Island., Molly Hokkanen
Theses and Dissertations
For dioecious plant species, sex ratios within a population depend on multiple environmental and life history characteristics. Sex ratio is an indicator of population health and can be a predictor for genetic bottlenecking. My study established the previously unknown sex ratio for the shrub, Morella cerifera, on a Virginia barrier island. The ratio was compared with multiple environmental and reproductive traits to determine their potential influence on sex determination and/or distribution of male and female plants. Multivariate analyses were used to identify relationships between sex, sex ratio and environmental drivers. The sex ratio for M. cerifera changed depending on scale. …
Effects Of Aromatherapy On Test Anxiety And Performance In College Students, Jocelyn Marie Dunnigan
Effects Of Aromatherapy On Test Anxiety And Performance In College Students, Jocelyn Marie Dunnigan
Theses and Dissertations
Test anxiety is a complex, multidimensional construct composed of cognitive, affective, and behavioral components that have been shown to negatively affect test performance. Furthermore, test anxiety is a pervasive problem in modern society largely related to the evaluative nature of educational programs, therefore meriting study of its nature, causes, effects, and treatment. Aromatherapy is the skilled use of essential oils for physical and emotional well-being and has been used to increase relaxation, attention and memory. This study examined the effects of peppermint and rosemary aromatherapy essential oils and a control scent (apple) on self-reported test anxiety, emotionality and worry subscales …
Smart Superhydrophobic Materials, Adetoun Taiwo
Smart Superhydrophobic Materials, Adetoun Taiwo
Theses and Dissertations
Superhydrophobicity refers to surfaces with extremely large water droplet contact angles (usually greater than 150°). This phenomenon requires a hydrophobic material with micro or nano-scale roughness. Superhydrophobic surfaces exist in nature (e.g. the lotus leaf) and can be produced synthetically. This project focuses on the development and characterization of superhydrophobic materials with tunable wettability (i.e. smart superhydrophobic materials). In this study, surfaces were prepared by electrospinning thin, aligned polystyrene fibers onto a piezoelectric unimorph substrate. Results showed electric field induced changes in substrate curvature, which produced corresponding changes in surface wettability. From experiments, an average change in water contact angle …
Risk Assessment In Corrections: An Analysis Of Variables Related To Suicide Attempts And Self-Mutilation, Melissa Ann Fine
Risk Assessment In Corrections: An Analysis Of Variables Related To Suicide Attempts And Self-Mutilation, Melissa Ann Fine
Theses and Dissertations
Suicide and self-mutilation risk assessment is a complicated process, especially within a correctional setting. According to the Bureau of Justice Statistics, over 50% of incarcerated individuals have a mental health illness, further reinforcing the need for concise, evidence-based risk assessment practices. The Virginia Department of Corrections collected data on suicide attempts, completed suicides, and incidents of self-injurious behavior for 17 months with a measure created to assess risk factor found in the community. Results indicated that numerous factors were related to suicide attempts, however only having made prior suicide attempts, the presence of a major depression diagnosis, and placement in …
Interactive Empathy And Leader Effectiveness: An Evaluation Of How Sensing Emotion And Responding With Empathy Influence Corporate Leader Effectiveness, Gerald Burch
Theses and Dissertations
Empathy has been shown to be a very powerful social and work ability. This study surveyed 754 employees of a privately held eastern United States company, and incorporated annual performance evaluations to empirically link interactive empathy to leader performance of 102 leaders. Data was collected from the leader’s followers, peers, and supervisors and from self-report personality evaluations. The results of this study show that leaders that are willing to engage their followers with empathic displays are seen as better leaders from their supervisors and have more engaged employees. Other contributions of this study include validation of the interactive empathy scale …
The Relation Between Patterns Of Beliefs About Fighting And Social Information-Processing: Differences In Cognitions, Goals, And The Response-Decision Process In Adolescents, Denicia Titchner
Theses and Dissertations
Beliefs about aggression play a key role in how youth interpret and respond to social situations and are related to aggressive behavior. Adolescents may report beliefs supporting aggression and engage in aggression due to reinforcement within their environment, rather than due to maladaptive social information-processing (SIP) biases. The purpose of this study was to examine adolescents’ patterns of beliefs about aggression and how these patterns relate to SIP. This study used latent class analysis (LCA), the Articulated Thoughts in Simulated Situations paradigm, and a Problem Solving Interview to examine differences in SIP between adolescents with varying patterns of beliefs about …
A Novel Biorelevant In Vitro System To Predict The In Vivo Performance Of Oral Transmucosal Products, Poonam Delvadia
A Novel Biorelevant In Vitro System To Predict The In Vivo Performance Of Oral Transmucosal Products, Poonam Delvadia
Theses and Dissertations
In vitro dissolution, release and permeation testing is a common practice during drug product research and development. These in vitro tests, if predictive, are referred to as biorelevant tests and can play diverse roles to facilitate and expedite product development in a cost effective manner. Oral transmucosal products (OTPs) are currently tested using compendial and modified in vitro tests which may or may not be good predictors of in vivo performance due to a lack of biorelevance. A critical need for a broadly applicable and biorelevant in vitro system for OTPs has been expressed in the literature and the goal …
Paired Interactions Between Kir Channels And Tertiapin-Q, Chul Ho Yang
Paired Interactions Between Kir Channels And Tertiapin-Q, Chul Ho Yang
Theses and Dissertations
Kir channels serve diverse and important roles throughout the human body and malfunctions of these channels are implicated in various channelopathies. Specific inhibitors for different subtypes of Kir channels are not available. However, Tertiapin-Q (TPNQ), a polypeptide isolated from honey bee venom, differentially inhibits certain subtypes of Kir channels with nanomolar affinity: ROMK1 (Kir1.1) and GIRK1/GIRK4 (Kir3.1/Kir3.4). Modification of TPNQ to increase selectivity for target channels bears great therapeutic potential. The in silico studies based on TPNQ-docked channel models, ROMK1_IRK2 (Kir1.1_Kir2.2) and GIRK2 (Kir3.2), predicted specific paired residue interactions and were experimentally validated here. In ROMK1 E123A mutant, the TPNQ …
Anti-Cytomegalovirus Activity Of Atanyl Blue Prl, An Anthraquinone Derivative, Zohaib Alam
Anti-Cytomegalovirus Activity Of Atanyl Blue Prl, An Anthraquinone Derivative, Zohaib Alam
Theses and Dissertations
Cytomegalovirus (CMV) is a significant cause of mortality and morbidity in immunocompromised patients and an important cause of birth defects if acquired in utero. The licensed CMV antivirals, ganciclovir, cidofovir and foscarnet, all target the viral DNA polymerase. For each drug prolonged use is associated with significant toxicities and development of drug resistance. None are approved for use during pregnancy. Therefore, development of new anti-CMV drugs that target different pathways would be beneficial. All herpesviruses encode an alkaline nuclease. That genetic disruption of the CMV alkaline nuclease, UL98, reduces CMV replication by 1,000-fold suggests that UL98 may be a useful …
Spatial And Temporal Estimation Of Nanomechanical Properties Via Atomic Force Microscopy, Eric Mccullough
Spatial And Temporal Estimation Of Nanomechanical Properties Via Atomic Force Microscopy, Eric Mccullough
Theses and Dissertations
Engineering the next generation of smart materials will require new methods of surface characterization, analysis and identification that can be performed not only in three dimensional space but also in the temporal dimension. Of particular interest is the understanding of mechanical properties of complex systems at the micro and nanoscales. Current techniques for such measurements are hampered by challenges including their inability to probe systems in complex microenvironments, non-destructively, or at nanometer resolution. This thesis outlines work in the development of techniques to study diverse systems and determine their mechanical properties using the Atomic Force Microscope as the primary tool. …
Semi-Interpenetrating Network Gelatin Fiber Sca Old For Oral Mucosal Delivery Of Insulin, Leyuan Xu
Semi-Interpenetrating Network Gelatin Fiber Sca Old For Oral Mucosal Delivery Of Insulin, Leyuan Xu
Theses and Dissertations
Common therapy for diabetes mellitus is subcutaneous administration of insulin that is subject to serious disadvantages, such as patient noncompliance and occasional hypoglycemia. Hence, oral administration of insulin could be more convenient and serve as a desired route. However, oral administration of insulin is severely limited by the low bioavailability of insulin through the gastrointestinal tract. In this study, a semi-interpenetrating network gelatin fiber scaffold (sIPN GF) was fabricated for oral mucosal delivery of insulin as an alternative route. This sIPN GF was engineered from an electrospun gelatin fiber scaffold (GF), which was further crosslinked with polyethylene glycol diacrylate (PEG-DA) …
The Effects Of Saltwater Intrusion On Methanogen Community Abundance, Structure, And Activity, Jaimie Gillespie
The Effects Of Saltwater Intrusion On Methanogen Community Abundance, Structure, And Activity, Jaimie Gillespie
Theses and Dissertations
Tidal freshwater wetlands (TFW) are at significant risk of loss or alteration due to global climate change, and saltwater intrusion from sea level rise is of particular concern for these habitats due to their proximity to coastal areas. A space-for-time model was used to investigate the effects of saltwater intrusion on soil methanogen communities along naturally occurring salinity gradients on the Waccamaw, James, and Hudson Rivers. Amplification of the methyl coenzyme-M reductase (mcrA) functional gene was used in qPCR, reverse transcription qPCR, and T-RFLP to measure the abundance, activity, and community composition of soil methanogens. Both the abundance and activity …
Exploring Electric Field-Induced Changes In Astrocyte Behavior, Doel Dhar
Exploring Electric Field-Induced Changes In Astrocyte Behavior, Doel Dhar
Theses and Dissertations
Electric fields, which are generated by the movement of charged ions across membranes, are found in all biological systems and can influence cellular components ranging from amino acids to biological macromolecules. Physiological field strengths range from 1 – 200 mV/mm, and these electric fields are especially elevated at sites of cellular growth during development and regeneration. It has previously been demonstrated that elevated electric fields induce alignment of astrocyte processes in vitro, enhancing the rate of neurite outgrowth. It is believed that electric fields of varying physiological strength affect other astrocytic responses associated with regeneration. To characterize the duration over …
Content Analysis Of Cognitive Distortions In Pedophiles' Online Forum Posts, Lyndsie Johnson
Content Analysis Of Cognitive Distortions In Pedophiles' Online Forum Posts, Lyndsie Johnson
Theses and Dissertations
Historically, sexual encounters between adults and children were rarely reported to authorities, and thus considered a rare problem. However, as many as 33% of girls and 14% of boys experience sexual encounters with adults and as a result may experience consequences such as aversive feelings regarding the act of sex, substance abuse, and self-mutilation. Such consequences lead research to examine pedophile's cognitive distortions. This exploratory study examined pedophiles' website forum posts to determine if any posters demonstrated cognitive distortions. Four independent raters used content analysis to determine which cognitive distortions were demonstrated by the examined pedophiles. Results suggested that cognitive …
Characterization Of Cyclic Di-Gmp Binding By The Sole Borrelia Burgdorferi And Borrelia Hermsii Pilz Domain-Containing Proteins, Katherine Louise Mallory
Characterization Of Cyclic Di-Gmp Binding By The Sole Borrelia Burgdorferi And Borrelia Hermsii Pilz Domain-Containing Proteins, Katherine Louise Mallory
Theses and Dissertations
Borrelia burgdorferi and Borrelia hermsii cause Lyme disease and relapsing fever, respectively. These spirochetes are maintained in an enzootic cycle, involving tick vectors and mammalian hosts. Differential gene expression is central in their survival in various environmental conditions. C-di-GMP has been demonstrated to be important in bacterial adaptation. Borrelia deletion mutant phenotypes have shown that c-di-GMP regulates motility, infectivity, and enzootic cycle progression. As the only known receptors encoded by Borrelia, PlzA and PlzC characterization is necessary in delineating c-di-GMP roles within the cell. In this study, biochemical, biophysical, and FRET methods demonstrated that these proteins exhibit a structural rearrangement …
An Analysis Of The Underrepresentation Of Black Students In The Advanced Placement Program: Implications For Postsecondary Access, Faye Lewis
Theses and Dissertations
Using a qualitative approach, this study explored the factors that contribute to the underrepresentation of Black students in the AP program. The sample was comprised of 12 Black students who attended a suburban public high school in New Jersey. Seven of the participants were enrolled in AP classes and five were enrolled in Honors classes. Themes unique to the AP group were: discomfort and isolation in AP courses and teacher expectations. The theme that emerged from the non AP student interviews was comfort in Honors. Themes common to both groups were: lack of AP information, the impact of guidance counselors, …
Fabrication Of Surface Amine Gradients By Controlled-Rate Infusion For Chromatographic Applications, Balamurali Kannan
Fabrication Of Surface Amine Gradients By Controlled-Rate Infusion For Chromatographic Applications, Balamurali Kannan
Theses and Dissertations
Surface gradients are materials that exhibit a variation in properties such as chemical composition, topography etc., in a continuous and/or discrete fashion. They are broadly classified as chemical and physical gradients depending upon the properties that gradient exhibits. Among those, chemical gradients on various surfaces have been a great interest in materials research for the last two decades. This is due to the applications of gradients in various fields such as biological sciences, separation science, etc. There have been several different approaches developed for the preparation of chemical gradients. Silane-based approaches are among those that are widely used because of …
Phylogeography And Species Status Of Ramphogordius Sanguineus, Cora Runnels
Phylogeography And Species Status Of Ramphogordius Sanguineus, Cora Runnels
Theses and Dissertations
Ramphogordius sanguineus (Rathke 1799) is a gregarious nemertean with a worldwide distribution and found mainly on hard substrates associated with mussels, oysters and other organisms of the fouling community. Asexual reproduction occurs by spontaneous fragmentation and only anecdotal accounts of sexual reproduction exist. This is the first phylogeographic study of R. sanguineus as well as the first species delimitation analyses employing DNA markers. Analysis of the mitochondrial gene nad6 and nuclear ISSR markers showed little diversity among geographically widespread populations, but AMOVA analyses of both markers revealed moderate to high genetic differentiation. Populations from Maine and Massachusetts exhibited the highest …
Ex Vivo Reprogramming Of Tumor-Reactive Immune Cells From Fvbn202 Mice Bearing Lung Metastatic Mammary Carcinoma: An Immunotherapeutic Opportunity Revealed Against Recurrence, Charles Hall
Theses and Dissertations
Metastatic breast cancer treatment has seen few advances in recent years, yet treatment resistance continues to rise, causing disease recurrence. A pilot study was performed to determine the efficacy of ex vivo expansion and reprogramming of tumor-reactive immune cells from experimental metastatic tumor-sensitized mice. Also, phenotypic changes in tumors due to metastasis or tumor microenvironment influences were characterized. Metastatic neu+ mouse mammary carcinoma (mMMC) and its distant relapsing neu-antigen-negative variant (mANV) were investigated in FVBN202 mice. Tumor-reactive central memory CD8+ T cells and activated NK/NKT cells were successfully reprogrammed and expanded during 6-day expansion from mMMC- and/or mANV-sensitized mice, resulting …
Role Of Tyk2 In Regulating Energy Expenditure And Preventing Obesity, Vidisha Raje
Role Of Tyk2 In Regulating Energy Expenditure And Preventing Obesity, Vidisha Raje
Theses and Dissertations
Obesity develops when energy intake exceeds energy expenditure. Defect in the function of brown fat and skeletal muscle, two of the major tissues that contribute towards energy expenditure, lead to the development of obesity and metabolic syndrome. Our previous findings suggest that Tyk2 deficient mice become obese and develop the metabolic syndrome. Tyk2, which is a tyrosine kinase of the JAK-STAT signaling family, is important for optimal brown development and function. Since brown fat and skeletal muscle, both are derived from the Myf5+ lineage of mesenchymal stem cells, we also characterized the role of Tyk2 in the development and function …
Genetic Dissection Of Quantitative Trait Loci For Substances Of Abuse, Jo Lynne Harenza
Genetic Dissection Of Quantitative Trait Loci For Substances Of Abuse, Jo Lynne Harenza
Theses and Dissertations
It has been reported that an individual’s initial level of response to a drug might be predictive of his or her future risk of becoming dependent, thus basal gene expression profiles underlying those drug responses may be informative for both predicting addiction susceptibility and determining targets for intervention. This dissertation research aims to elucidate genetic risk factors underlying acute alcohol and nicotine dependence phenotypes using mouse genetic models of addiction. Phenotyping, brain region-specific mRNA expression profiling, and genetic mapping of a recombinant inbred panel of over 25 mouse strains were performed in order to identify quantitative trait loci (QTL) harboring …
Identification And Characterization Of Ethanol Responsive Genes In Acute Ethanol Behaviors In Caenorhabditis Elegans, Joseph Alaimo
Identification And Characterization Of Ethanol Responsive Genes In Acute Ethanol Behaviors In Caenorhabditis Elegans, Joseph Alaimo
Theses and Dissertations
Alcohol abuse and dependence are complex disorders that are influenced by many genetic and environmental factors. Acute behavioral responses to ethanol have predictive value for determining an individual’s long-term susceptibility to alcohol abuse and dependence. These behavioral responses are strongly influenced by genetics. Here, we have explored the role of genetic influences on acute behavioral responses to ethanol using the nematode worm, Caenorhabditis elegans. First, we explored the role of ethanol metabolism in acute behavior responses to ethanol. Natural variation in human ethanol metabolism machinery is one of the most reported and reproducible associations found to alter drinking behavior. Ethanol …
Completing College: A Longitudinal Examination Of Potential Antecedents Of Success In Post-Secondary Education For Students With Disabilities, Edwin Achola
Theses and Dissertations
The purpose of this study was to determine the antecedent conditions that contribute to post-secondary education (PSE) completion for students with disabilities, taking into account institutional experiences associated with social integration. A prospective longitudinal design was used to analyze data from the National Longitudinal Transition Study-2. The study sample consisted of youth who were currently enrolled in vocational schools, two-year community colleges, and four-year universities six years after high school exit. Logistic regression was used to examine the relationships between pre-entry variables and PSE completion. To test the hypothesis of mediation, the causal step approach (Baron & Kenny, 1986) was …
Physiological Mechanisms Of Shrub Encroachment: Linking Enhanced Hydraulic Capacity To Efficient Light Capture And Processing, Sheri Shiflett
Physiological Mechanisms Of Shrub Encroachment: Linking Enhanced Hydraulic Capacity To Efficient Light Capture And Processing, Sheri Shiflett
Theses and Dissertations
Woody plant expansion has been documented for decades in many different ecosystems, often due to anthropogenic disturbances to the environment and yielding vast changes in ecosystem functioning. While causes and consequences of woody expansion have been well documented, few studies have investigated functional traits of woody species that promote rapid expansion in range. My objective was to determine if hydraulic efficiency confers enhanced photosynthetic efficiency so that functional traits representing light and water use may be possible mechanisms facilitating woody encroachment into grasslands and forest understories. I quantified leaf-level light environment, photosynthetic activity, and hydraulic characteristics of three sympatric broadleaf …
Studies Toward The Synthesis Of Lyconadin A And Cranomycin, Brad M. Loertscher
Studies Toward The Synthesis Of Lyconadin A And Cranomycin, Brad M. Loertscher
Theses and Dissertations
Lyconadin A is a pentacyclic Lycopodium alkaloid isolated from the club moss Lycopodium companatum with anticancer activity. Our approach sought to incorporate a 7-exo–6-exo acyl radical cyclization cascade to access the bicyclo[5.4.0]undecane framework of lyconadin A. Our studies created methodology for the synthesis of 5-alkyl and 3,5-dialkyl-6-carbomethoxy-2-pyridones and sterically demanding epoxide substrates. These epoxide substrates underwent an unanticipated Payne rearrangement.Cranomycin is a potent antibiotic with antiprotozoal activity. Structurally it is a cyclopentane ring system with substitution at each carbon in the ring. Another interesting structural aspect is the existence of three contiguous quaternary stereocenters including two tertiary alcohols and a …
Longitudinal Predictors Of Quality Of Life In Adolescent Survivors Of Childhood Cancer: A Report From The Childhood Cancer Survivor Study, Claire C. Russell
Longitudinal Predictors Of Quality Of Life In Adolescent Survivors Of Childhood Cancer: A Report From The Childhood Cancer Survivor Study, Claire C. Russell
Theses and Dissertations
Objective: The impact of childhood cancer on future quality of life (QoL) in survivors is unclear. Current studies focus on comparing outcomes to healthy peers and identifying related treatment and demographic variables, but a shift in our approach is necessary. This study is guided by the Wilson and Cleary Model (WMC) and seeks to identify longitudinal predictors of QoL in adolescent survivors of cancer that explain variance in QoL beyond the impact of treatment and demographic variables. Methods: The Childhood Cancer Survivor Study (CCSS) is a multi-institutional longitudinal study following a cohort of childhood cancer survivors. This study focuses on …
Validation Of Copy Number Variants Associated With Schizophrenia Risk In An Irish Population And Implications To Clinical Practice, Rachel L. Elves
Validation Of Copy Number Variants Associated With Schizophrenia Risk In An Irish Population And Implications To Clinical Practice, Rachel L. Elves
Theses and Dissertations
Schizophrenia is a complex disorder affecting 1% of the population and is highly heritable, but the majority of contributing genetic factors has remained elusive. Current risk estimates for clinical practice are primarily determined by family history and associated empirical risk. Copy number variants (CNVs) may hold the key to explaining the missing heritability in schizophrenia research; schizophrenia risk estimates as high as 30% have been found for the most-studied CNV associated with schizophrenia, 22q11. Currently, there are methods to identify CNVs though previously collected data from SNP microarrays that would facilitate these types of studies. To determine if algorithms that …
Beta-Amyloid Inhibition Of Alpha 7 Nicotinic Acetylcholine Receptors And Factors That Potentially Influence The Aî²/Nachr Interaction, Christopher L. Jacobsen
Beta-Amyloid Inhibition Of Alpha 7 Nicotinic Acetylcholine Receptors And Factors That Potentially Influence The Aî²/Nachr Interaction, Christopher L. Jacobsen
Theses and Dissertations
Alzheimer's disease (AD) is a neurodegenerative disorder that manifests in the form of deficiencies in cognitive processes such as memory and learning. The pathological features of AD include hyperphosphorylated tau proteins that form neurofibrillary tangles as well as senile plaques composed primarily of the peptide β-amyloid (Aβ). When present in high concentrations in the brain, Aβ inhibits certain subtypes of neuronal nicotinic acetylcholine receptors (nAChRs) in the hippocampus. The effects of Aβ in the hippocampus have proven to be neurotoxic, resulting in reduced functionality of nAChRs and the subsequent death of neurons in the cholinergic pathway. The early stages of …