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High-Resolution Mri For 3d Biomechanical Modeling: Signal Optimization Through Rf Coil Design And Mr Relaxometry, James A. Badal
High-Resolution Mri For 3d Biomechanical Modeling: Signal Optimization Through Rf Coil Design And Mr Relaxometry, James A. Badal
Theses and Dissertations
Computed Tomography (CT) is often used for building 3D biomechanical models of human anatomy. This method exposes the subject to a significant x-ray dose and provides limited soft-tissue contrast. Magnetic Resonance Imaging (MRI) is a potential alternative to CT for this application, as MRI offers significantly better soft-tissue contrast and does not expose the subject to ionizing radiation. However, MRI requires long scan times to achieve 3D images at sufficient resolution, signal-to-noise ratio (SNR), and contrast-to-noise ratio (CNR). These long scan times can make subject motion a problem. This thesis describes my work to reduce scan time while achieving sufficient …
A Systematic Study Of The Optical And Electrical Properties Of Ge1-YSnY And Ge1-X-YSiXSnY Semiconductor Alloys, Thomas R. Harris
A Systematic Study Of The Optical And Electrical Properties Of Ge1-YSnY And Ge1-X-YSiXSnY Semiconductor Alloys, Thomas R. Harris
Theses and Dissertations
In order to fully utilize newly developed Ge1-ySny and Ge1-x-ySixSny materials for new novel optoelectronic devices, the optical and electrical properties of these alloys were investigated using photoluminescence (PL) and Hall-effect measurements. Direct bandgap PL emission was observed from almost all the samples, making them very promising candidates for Si-based light emitting devices. T-dependent PL studies also indicate that the indirect-to-direct bandgap transition of Ge1-ySny alloys might take place at a much lower Sn content than the theory predicts. T-dependent Hall-effect measurements showed both degenerate parallel conducting layers as …
Inhibition Of Pim And Axl Kinases As Potential Treatments For A Variety Of Hematological Malignancies And Solid Tumors, Kent James Carpenter
Inhibition Of Pim And Axl Kinases As Potential Treatments For A Variety Of Hematological Malignancies And Solid Tumors, Kent James Carpenter
Theses and Dissertations
This thesis is divided into three chapters. In each case, the goal is to achieve inhibition of a growth kinase (PIM or AXL) and subsequent arrest of cell growth and induction of apoptosis (in vitro cell culture models) or decrease in tumor volume (in vivo xenograft studies). Chapter one and chapter two discuss inhibition of proviral integration site for Moloneymurine leukemia virus (PIM) kinases. The three PIM kinases, PIM-1, PIM-2, and PIM-3, are a subfamily of serine/threonine kinases that are known to be involved in signaling pathways as downstream effectors of signal transducer and activator of transcription-5 (STAT5) signaling and …
Hydroxocobalamin Treatment For Carbon Monoxide Exposures: Characterizing Hemoglobin Changes And Testing For Neurological Sequelae, Leonardo Somera
Hydroxocobalamin Treatment For Carbon Monoxide Exposures: Characterizing Hemoglobin Changes And Testing For Neurological Sequelae, Leonardo Somera
Theses and Dissertations
Prior work in our lab has indicated that reduced Hydroxocobalamin (B12r) can be added to human blood and is able to convert carbon monoxide (CO) into carbon dioxide. This has great potential as a direct antidote to mitigate the toxic effects of CO poisoning which is a public health risk. In the first part of our work, we use highly specific wavelengths of light and Raman spectroscopy to study changes in Carboxyhemoglobin (COHb) between blood treated with oxygen and blood treated with oxygen and B12r in a flowing circuit of blood. Using Raman spectroscopy, we found that the addition of …
The Use Of Geographic Information Systems By Law Enforcement Agencies And Its Impact On Police Performance, Kun Ulvi
Theses and Dissertations
Do we know whether the use of geographic information systems (GIS) in law enforcement agencies increases police performance? This study examines the impact of GIS use to police performance outcomes in cities and counties of the U.S. between 2000 and 2007. Current research uses computerized mapping conceptualization to operationalize its measurement. Second, the police performance methodological context is used to measure the organizational impact of GIS. Finally, a new theoretical framework, information technology capacity that combines organizational, environmental and managerial factors to explain IT applications, is used to encompass most relevant dimensions of the subject matter. Findings indicate that the …
On Chip Preconcentration And Labeling Of Protein Biomarkers Using Monolithic Columns, Device Fabrication, Optimization, And Automation, Rui Yang
Theses and Dissertations
Detection of disease specific biomarkers is of great importance in diagnosis and treatment of diseases. Modern bioanalytical techniques, such as liquid chromatography with mass spectrometry (LC-MS), have the ability to identify biomarkers, but their cost and scalability are two main drawbacks. Enzyme-linked immunosorbent assay (ELISA) is another potential tool, but it works best for proteins, rather than peptide biomarkers. Recently, microfluidics has emerged as a promising technique due to its small fluid volume consumption, rapidness, low fabrication cost, portability and versatility. Therefore, it shows prominent potential in the analysis of disease specific biomarkers. In this thesis, microfluidic systems that integrate …
Architecture Analyses Of Le Corbusier’S Villa Savoye, Labinot Mehmeti
Architecture Analyses Of Le Corbusier’S Villa Savoye, Labinot Mehmeti
Theses and Dissertations
Le Corbusier remains a very challenging and elusive subject in architectural scholarship today due to the complexity and depth of his work. Critical analyses on his work generally stress one particular design theme or interpretive concept, such as the classical tradition, universalization, machine aesthetics, synthesis of the arts, or mysticism and ambiguity; they never fully explain the depth of his art. He is one of the most significant contributions to modern architecture in the 20th century, Villa Savoye by Le Corbusier. Completed in 1929, Villa Savoye is a modern take on a French country house that celebrates and …
Cloning, Expression And Preliminary Characterization Of A Novel Nitrilase From The Red Sea, Atlantis Ii Deep Brine Pool Using A Metagenomic Approach, Sarah Ali Sonbol
Cloning, Expression And Preliminary Characterization Of A Novel Nitrilase From The Red Sea, Atlantis Ii Deep Brine Pool Using A Metagenomic Approach, Sarah Ali Sonbol
Theses and Dissertations
With the abundance of hazardous nitrile compounds in nature and with the extensive use of them in industries of fine chemicals, the attention towards nitrilases has profoundly increased as biocatalysts in different industries and in bioremediation. The use of nitrilases, which hydrolyze nitriles into carboxylic acids and ammonia, was introduced as a biological method superior to conventional chemical means. In contrast to conventional microbiological techniques using cultured microorganisms, and with the loads of genomic sequences available in the databases, identification of novel nitrilases using metagenomic approaches seems more promising. In this study, a nitrilase was isolated from the microbial metagenomic …
Fate Of Natural Organic Matter And Formation Of Disinfection By-Products In A Conventional Water Treatment Plant, Noha Hesham Abdel Halim
Fate Of Natural Organic Matter And Formation Of Disinfection By-Products In A Conventional Water Treatment Plant, Noha Hesham Abdel Halim
Theses and Dissertations
Elevated levels of disinfection by-products (DBPs), detected in Cairo residential water supply during the past decade, were the motivation to study the process of DBP formation at the water treatment plant (WTP) stage. It is hoped that an in-depth understanding of natural organic matter (NOM) characteristics and DBP formation/removal in an existing WTP will yield a baseline as well as insights for the development of optimum strategies for cost-effective reduction of potentially harmful drinking water compounds such as Trihalomethanes (THMs) and Haloacetic acid (HAAs). The objectives of this research were to: investigate the degree of removal of the various NOM …
Incorporating Construction And Demolition Waste Into Non-Load Brearing Bricks., Neveen Samy Talaat Soliman
Incorporating Construction And Demolition Waste Into Non-Load Brearing Bricks., Neveen Samy Talaat Soliman
Theses and Dissertations
Egypt faces serious solid waste management challenges. Currently, waste is either burned or dumped along roads and canals. Not only do these wastes cause health problems, but they also contribute significantly to soil, air, and water pollution. Solid waste can be categorized as residential, industrial, institutional, municipal, manufacturing, and construction and demolition waste (C&DW). The construction industry threatens the environment in three main ways: during the production of raw materials in the process of cement and aggregate production; during the construction process itself due to high consumption of energy; and, in the final stages of the construction process due to …
Law Is Discourse. Discourse Is Rhetoric. Therefore, Law Is Rhetoric. A Rhetorical Analysis Of The Responsibility To Protect, Dina El-Kassaby
Law Is Discourse. Discourse Is Rhetoric. Therefore, Law Is Rhetoric. A Rhetorical Analysis Of The Responsibility To Protect, Dina El-Kassaby
Theses and Dissertations
It is estimated that the yearly cost of containing and responding to conflict worldwide is nearly US$10 trillion. Meanwhile, the level of global peace and security is on the steady decline and gross violations of human rights and massive loss of human life are not yet an issue of the past. As such, contemporary international legal doctrines like The Responsibility to Protect (R2P) have emerged in an effort to prevent and react to global conflict. This thesis performs an atypical study of R2P by performing a rhetorical analysis of the doctrine through the lens of Orientalism and post-colonial theory. In …
Identification Of T-Cell Epitopes In The Hepatitis C Virus Genotype 4 Proteome: A Step Towards Epitope-Driven Vaccine Development, Karim Mohamed Ali Abdel-Hady
Identification Of T-Cell Epitopes In The Hepatitis C Virus Genotype 4 Proteome: A Step Towards Epitope-Driven Vaccine Development, Karim Mohamed Ali Abdel-Hady
Theses and Dissertations
Hepatitis C is an inflammatory infectious disease of the liver caused by the Hepatitis C Virus (HCV). It is a global pandemic, chronically inflicting 150 million people worldwide, with millions of new infections arising annually. The standard therapy of HCV is expensive, associated with severe side effects, and has variable success rates. Thus far, no HCV vaccine has been developed, owing to the challenges that faced and still face its development. Despite these challenges, several attempts have been taken to develop a vaccine, some of which have progressed to phase II clinical trials. Most of these attempts, however, have focused …
Risky Bodies Offshore: Spatialisation, Securitisation And Visual Regimes Of Migration, Angela Smith
Risky Bodies Offshore: Spatialisation, Securitisation And Visual Regimes Of Migration, Angela Smith
Theses and Dissertations
No abstract provided.
Investigation Of Reinforced Foam Waste With Natural Or Synthetic Fibers, Riham Abdel Mohsen
Investigation Of Reinforced Foam Waste With Natural Or Synthetic Fibers, Riham Abdel Mohsen
Theses and Dissertations
The production of plastics has reached about 300 million tons globally each year. The use of energy resources, the health problem and the impacts on the environment from its disposal phase trigger overriding concerns on plastic recycling which can both save energy consumption in production phase and achieve green end-of-life approach for plastics. Polystyrene is hardly biodegradable. It takes at least 500 years to decompose. It is estimated that by volume, it takes as much as thirty percent of landfills worldwide. It is also flammable subject to risk of accidental ignition and cause of huge fires. Polystyrene is not recycled …
Modulators Of Mrp1 Promoter In Neuroblastoma Cell Lines, Myret Said Ghabriel
Modulators Of Mrp1 Promoter In Neuroblastoma Cell Lines, Myret Said Ghabriel
Theses and Dissertations
The long term goal of this research proposal is to further understand the transcriptional regulation of the MRP1 promoter in neuroblastoma cells. We are primarily focused on two possible mechanisms that might lead to the regulation of MRP1 expression: epigenetic modifications, in particular, gene promoter methylation and transcription factors namely the regulation by the methyl binding protein (MeCP2). Within the 5’ untranslated region of the MRP1 promoter is a CpG island that has the potential to be methylated, thus contributing to down regulation of MRP1 expression in drug sensitive neuroblastoma cells. Our goal is to determine if methylation status of …
Beyond Aristotelianism: Al-Farabi On Revelation, Humans And Animals In His On The Perfect State, Michael William Stark
Beyond Aristotelianism: Al-Farabi On Revelation, Humans And Animals In His On The Perfect State, Michael William Stark
Theses and Dissertations
In modern times, Aristotelian influence on Islamicate philosophical writing is exaggerated. Al-Fārābī did more than just copy Aristotle, he was an original thinker, and he may have sourced aspects of his thought and writing style from the Qurʾān. Consideration of al-Fārābī’s biography, works and historical context demonstrates his disinclination to base his writings on those of Aristotle. Al-Fārābī’s thoughts in the key area of revelation in al-Madīna al-fāḍila demonstrate his departure from ancient Greek belief in this area, although his use of individual reasoning also shows clearly his occasional disagreement with Islamic doctrine. Differences and commonalities between animals and humans …
Polymeric Monolithic Stationary Phases For Capillary Reversed-Phase Liquid Chromatography Of Small Molecules, Kun Liu
Theses and Dissertations
Highly cross-linked monoliths prepared from single cross-linking monomers were found to increase surface area and stability. Therefore, seven cross-linking monomers, i.e., 1,3-butanediol dimethacrylate (1,3-BDDMA), 1,4-butanediol dimethacrylate (1,4-BDDMA), neopentyl glycol dimethacrylate (NPGDMA), 1,5-pentanediol dimethacrylate (1,5-PDDMA), 1,6-hexanediol dimethacrylate (1,6-HDDMA), 1,10-decanediol dimethacrylate (1,10-DDDMA), and 1,12-dodecanediol dimethacrylate (1,12-DoDDMA), were used to synthesize highly cross-linked monolithic columns in 75-µm i.d. capillaries by one-step UV-initiated polymerization using dodecanol and methanol as porogens for reversed-phase liquid chromatography (RPLC) of small molecules. Selection of porogen type and concentration was investigated in detail. Isocratic elution of alkylbenzenes at a flow rate of 300 nL/min was conducted for all of …
Transformative Education: Culture-Based Pedagogies In Urban, Predominately Black American Elementary Schools, Robin Harden-Daniels
Transformative Education: Culture-Based Pedagogies In Urban, Predominately Black American Elementary Schools, Robin Harden-Daniels
Theses and Dissertations
Problems facing Black American students in underfunded urban schools continue to threaten the viability of public education for this and other nontraditional student populations. These problems, along with the growing diversity of American children, prompt a reexamination of extant data on the practices associated with the effective teaching of Black American students. This meta-ethnography illuminates the findings of four case studies and then explores their implications for teaching. By looking through the lens of critical race theory, this study explores how effective teachers use culture-based instruction to better engage Black American students in the process of learning. Findings identify core …
Regulation Of Growth And Stress Tolerance In Tomato Plants By Expression Of A Dominant-Negative Version Of Erecta Gene From Arabidopsis Thaliana, Hector Ernesto Villagarcia
Regulation Of Growth And Stress Tolerance In Tomato Plants By Expression Of A Dominant-Negative Version Of Erecta Gene From Arabidopsis Thaliana, Hector Ernesto Villagarcia
Theses and Dissertations
Receptor kinases are the main group of signal recognition structures in plants. The large number and diversity of these receptors suggest that they perform major roles in a complex regulatory network of growth, development, and physiological responses. The ERECTA gene is a leucine-rich, receptor-like kinase that affects plant growth rates, stomatal patterning, transpiration efficiency, bacterial pathogen resistance, inflorescence and floral organ morphology, and leaf polarity. The ability to manipulate the ERECTA pathway in members of the Solanaceae family can reveal fundamental mechanisms including regulation of fruit and tuber development. This knowledge may enable changes in plant architecture and growth rates …
Studies On Theraputic Potential Of Dichloroacetic Acid And Hene Laser In Cancer Treatment: Understanding The Mechanism Of Action, Zeiyad Nassaif Al-Karakooly
Studies On Theraputic Potential Of Dichloroacetic Acid And Hene Laser In Cancer Treatment: Understanding The Mechanism Of Action, Zeiyad Nassaif Al-Karakooly
Theses and Dissertations
Cancer cells are often characterized by anaerobic glycolysis due to dysfunctional mitochondria that limits pyruvate uptake for aerobic respiration. Dichloroacetic acid (DCA), used in this study as a potential cancer treatment agent, targets mitochondria in cancer cells and is likely to correct mitochondrial dysfunction by resuming pyruvate uptake and therefore normal aerobic respiration. Our results suggest that DCA causes a significantly higher cytotoxicity in aggressive MCF-7 breast cancer cells than in non-aggressive MC3T3 osteoblastic cells. Apparently lower doses of DCA induce apoptosis whereas higher doses lead to non-specific cytotoxicity or necrosis. Increased cytotoxicity might be related to oxidative stress due …
Combined Antiproliferative Effects Of The Aminoalkylindole Win55,212-2 And Radiation In Breast Cancer Cells, Sean Emery
Combined Antiproliferative Effects Of The Aminoalkylindole Win55,212-2 And Radiation In Breast Cancer Cells, Sean Emery
Theses and Dissertations
The potential antitumor activity of mixed CB1/CB2 cannabinoid receptor agonists, such as the aminoalkylindole WIN55,212-2 (WIN2), has been extensively studied, but little information is available as to their potential interaction with conventional cancer therapies, such as ionizing radiation (IR). In the present work, we investigated the effects of WIN2 on the antiproliferative effects of radiation in human (MCF-7 and MDA-MB-231) and murine (4T1) breast cancer cells, as well as an immortalized human breast epithelial cell line (MCF-10A). WIN2 or radiation alone inhibited breast tumor growth, while the combination of WIN2 and radiation was more effective than either agent alone in …
The Effect Of Retinoic Acid On Rai1 And Identification Of Retinoic Acid Receptor Binding Site In Human Rai1, Bingjie Xue
The Effect Of Retinoic Acid On Rai1 And Identification Of Retinoic Acid Receptor Binding Site In Human Rai1, Bingjie Xue
Theses and Dissertations
Previous studies showed haploinsufficiency of RAI1 is the main cause of Smith-Magenis syndrome (SMS). SMS is a developmental neurobehavioral syndrome characterized by intellectual disability, congenital anomalies, obesity, neurobehavioral abnormalities, and disrupted circadian sleep-wake pattern. SMS is caused by deletion or mutation of chromosomal region 17p11.2 that includes RAI1. Studies in the Elsea lab have shown that RAI1 is a dosage-sensitive gene. Haploinsufficiency of RAI1 leads to dysregulation of CLOCK, NR1D2, POMC, and BDNF, which are responsible for circadian rhythm, metabolism, and cognitive development. Based on the data from Elsea’s recent study on zebrafish, rai1 gene expression in zebrafish is regulated …
Collisional Dynamic Elements Of The Pyrazine - N2o System:Middle And Low J States, La Moyne Tyler Mix
Collisional Dynamic Elements Of The Pyrazine - N2o System:Middle And Low J States, La Moyne Tyler Mix
Theses and Dissertations
Unimolecular reactions based on the Lindemann - Hinchelwood mechanism are important to understanding combustion and atmospheric processes. The main feature of this mechanism is the energy transfer probability distribution function, P(E',E). We have chosen to study P(E',E) through gas phase collisional dynamics probed with IR transient absorption spectroscopy. Post-collision absorption line widths for the pyrazine-N2O system are used to calculate lab frame translational temperatures. The translational temperatures reveal that collisions with large rotational energy transfer also transfer large amounts of translational energy. For J states >47 the relationship is linear indicating a constant impact parameter. Line widths for J=47 through …
A Study Of Census Driven Data In Single Parent Families And Their Implications, Lynn Coyle
A Study Of Census Driven Data In Single Parent Families And Their Implications, Lynn Coyle
Theses and Dissertations
Demographics for all school districts in Suffolk County, Long Island, New York were disseminated and analyzed in order to better understand where the highest percentage of single-parent households were located, how school districts support parents and children of single-parent households and how they could better assist them. As an outcome of this analysis, needs were identified in order to assist school leaders in creating an in-school support program. Researching the problems, challenges, and obstacles children face while living in single-parent households were an aid in this study. A preventative, mental health approach, an aspect of public health, is needed in …
The Effects Of Mental Illness On Trust Between Military Veterans, Kristina Marie Reihl
The Effects Of Mental Illness On Trust Between Military Veterans, Kristina Marie Reihl
Theses and Dissertations
Service members have reported the perception that seeking treatment for, and/or having a mental illness will cause a loss of trust between a service member and his/her leaders and peers (Nash, Silva, and Litz, 2009; Hoge et al, 2004). This study aimed to determine if the presence of a mental illness affects the trust between service members and determine whether other variables moderated this relationship. Using social media and Mechanical Turk an internet participant-recruiting site operated by Amazon, data were collected from 220 military Veterans. Participants were assessed using a research developed Demographics Questionnaire, the Combat Exposure Scale, The Unit …
Assessing Clinical Competency: The Simulated Patient Assessment And Research Collaboration, Jessica Ketterer
Assessing Clinical Competency: The Simulated Patient Assessment And Research Collaboration, Jessica Ketterer
Theses and Dissertations
The efficacy of using simulated patients (SPs) to train clinical interviewing skills in pre-practicum- and practicum-level mental health clinicians was evaluated compared to the use of traditional role-play with peers. Participants, regardless of group, engaged in a 15-minute videotaped simulated clinical session with an SP as a pre- and post-test measurement and completed five laboratory sessions, either utilizing role-play with peers or with an SP. Participants' counseling self-efficacy (CSE), measured by the Counseling Self-Estimate Inventory (COSE); state anxiety, measured by the State-Trait Anxiety Inventory, Version Y-1 (STAI Y-1); and self-reflective anxiety, measured by the Fear of Negative Evaluation scale (FNE), …
Predictors Of Post Foster Care Functioning: Assessing Emotional Intelligence In Foster Alumni, Nicole Englebert
Predictors Of Post Foster Care Functioning: Assessing Emotional Intelligence In Foster Alumni, Nicole Englebert
Theses and Dissertations
This study examined factors predictive of post foster care outcomes, with a particular focus on Emotional Intelligence (EI). EI was conceptualized using Bar-On's mixed model approach. Central study questions examined whether EI offered incremental prediction of several meaningful outcomes, over and above other contextual and individual variables. Outcomes included educational attainment, income level, various domains of Quality of Life (QOL), and mental health functioning. Twenty one foster alumni participated in the study. Correlational and hierarchical regression analyses were performed. Predictor variables were organized into four blocks and entered using a hierarchical method in the following order: contextual foster care factors, …
Do Parent And Teacher Ratings Of Behavior Measure What They Are Intended To Measure?, Phillip Martin
Do Parent And Teacher Ratings Of Behavior Measure What They Are Intended To Measure?, Phillip Martin
Theses and Dissertations
This study involves an examination of the neurocognitive correlates of subscales of the Conners' Rating Scale - Revised (CRS-R), an ADHD behavioral rating form, in both a child (n=72) and an adolescent (n=49) sample. While both behavioral rating forms and neuropsychological measures are commonly employed in pediatric clinical evaluations, these two forms of assessment do not generally converge as expected. The purpose of the current research was to examine and compare the abilities of intellectual, academic, attentional, and executive skills to account for variance in parent and teacher ratings of behavior across two pediatric age groups in a clinical setting. …
Attachment Style And Psychological Sense Of Community In The Context Of 12-Step Recovery, Amy Elizabeth Ellis
Attachment Style And Psychological Sense Of Community In The Context Of 12-Step Recovery, Amy Elizabeth Ellis
Theses and Dissertations
Approximately 10% of adults living in the United States meet criteria for a Substance Use Disorder. Although 12-step groups are considered evidence-based practices for substance use problems, an understanding of the underlying mechanisms by which they facilitate recovery practices remains in its infancy. The purpose of the current study was to explore whether attachment could be considered a possible mediator of the effects of recovery practices on positive psychosocial outcomes. Participants (N = 112) were self-identified NA members from 26 U.S. states who completed an online survey assessing attachment style, psychosocial sense of community, psychological well-being, and various other recovery …
Voltage Sensing Mechanism In The Voltage-Gated And Proton (H+)-Selective Ion Channel Hv1, Aaron L. Randolph
Voltage Sensing Mechanism In The Voltage-Gated And Proton (H+)-Selective Ion Channel Hv1, Aaron L. Randolph
Theses and Dissertations
Activation of the intrinsic aqueous water-wire proton conductance (GAQ) in Hv1 channels is controlled by changes in membrane potential and the transmembrane pH gradient (ΔpH). The mechanism by which changes in ΔpH affect the apparent voltage dependence of GAQ activation is not understood. In order to measure voltage sensor (VS) activation in Hv1, we mutated a conserved Arg residue in the fourth helical segment (S4) to His and measured H+ currents under whole-cell voltage clamp in transfected HEK-293 cells. Consistent with previous studies in VS domain containing proteins, we find that Hv1 R205H mediates a robust resting-state H+ ‘shuttle’ conductance …