Digital Commons Network^™

Eeg Interictal Spike Detection Using Artificial Neural Networks, Howard J. Carey Iii

Theses and Dissertations

Epilepsy is a neurological disease causing seizures in its victims and affects approximately 50 million people worldwide. Successful treatment is dependent upon correct identification of the origin of the seizures within the brain. To achieve this, electroencephalograms (EEGs) are used to measure a patient’s brainwaves. This EEG data must be manually analyzed to identify interictal spikes that emanate from the afflicted region of the brain. This process can take a neurologist more than a week and a half per patient. This thesis presents a method to extract and process the interictal spikes in a patient, and use them to reduce …

The Role Of Matrix Metalloproteinase 9 And Osteopontin In Synaptogenesis And Reinnervation Of The Olfactory Bulb Following Brain Injury, Melissa A. Powell

Theses and Dissertations

Traumatic brain injury (TBI) is a serious health concern, causing cognitive, motor, and sensory deficits, including olfactory dysfunction. This dissertation explores the effects of TBI on synaptic plasticity within the olfactory system, seeking to define mechanisms guiding postinjury sensory reinnervation. Physical forces induced by TBI can axotomize olfactory receptor neurons (ORNs), which innervate olfactory bulb (OB). These axons regenerate OB projections after injury, a process involving growth through a complex extracellular matrix (ECM). As such, we investigated a potential molecular mechanism capable of modifying local OB ECM to support postinjury synaptogenesis. Since matrix metalloproteinases (MMPs) and their ECM substrates are …

Characterization Of Poly(Dimethylsiloxane) Blends And Fabrication Of Soft Micropillar Arrays For Force Detection, Thomas J. Petet Jr

Theses and Dissertations

Diseases involving fibrosis cause tens of thousands of deaths per year in the US alone. These diseases are characterized by a large amount of extracellular matrix, causing stiff abnormal tissues that may not function correctly. To take steps towards curing these diseases, a fundamental understanding of how cells interact with their substrate and how mechanical forces alter signaling pathways is vital. Studying the mechanobiology of cells and the interaction between a cell and its extracellular matrix can help explain the mechanisms behind stem cell differentiation, cell migration, and metastasis. Due to the correlation between force, extracellular matrix assembly, and substrate …

Longitudinal Relations Between Parental Messages Supporting Fighting And Aggressive Behavior In Early Adolescence: The Moderating Role Of Positive Parenting Practices, Megan M. Carlson

Theses and Dissertations

The prevalence of physical aggression increases during adolescence and is associated with negative health outcomes. It is important to identify risk and protective processes for adolescent aggression in the context of the parent-adolescent relationship. The current study examined the potential moderating role of positive parenting at Wave 1 on relations between perceived parental messages supporting fighting at Wave 1 and adolescent aggression based on parent- and student-report at Wave 2. Participants included a sample of 537 adolescents and their primary caregivers, recruited from four sites in the U.S. No significant moderating effects were found. However, parental messages supporting fighting were …

Adjustment Profiles Among Youth In Diverse Cultural Contexts: Individual, Family, And Contextual Influences, Alicia Borre

Theses and Dissertations

Recent literature has noted that not all youth who experience adverse circumstances (e.g. poverty, exposure to violence, maltreatment) end up displaying expected unfavorable outcomes (e.g. academic failure, depression, drug dependence); in fact, some youth display “resilience,” broadly understood as adaptive functioning in the face of adversity (Luthar, Cicchetti, & Becker, 2000). Overall, research on resilience has offered a new approach to the study of at-risk populations, emphasizing the study of strengths, processes, and mechanisms among individuals and communities that may favor positive adaptation, rather than emphasizing deficits among those experiencing adversity (Schoon, 2012). Although resilience research has come a long …

The Role Of Enteric Glia In Opioid-Induced Constipation, Sukhada Bhave

Theses and Dissertations

Morphine is one of the most widely used drugs for the treatment of pain but its clinical efficacy is limited by adverse effects including persistent constipation and colonic inflammation. Morphine-induced colonic inflammation is facilitated by microbial dysbiosis and bacterial translocation. In this study, we demonstrate that secondary inflammation and persistent constipation are modulated by enteric glia. In chronic morphine treated mice (75 mg morphine pellet/5 days), ATP-induced currents were significantly enhanced in enteric glia isolated from the mouse colon myenteric plexus. Chronic morphine resulted in significant disruption of the colonic epithelium and increased Il-1β in the myenteric plexus. The increase …

Joint Detection-State Estimation And Secure Signal Processing, Mengqi Ren

Theses and Dissertations

In this dissertation, joint detection-state estimation and secure signal processing are studied. Detection and state estimation are two important research topics in surveillance systems. The detection problems investigated in this dissertation include object detection and fault detection. The goal of object detection is to determine the presence or absence of an object under measurement uncertainty. The aim of fault detection is to determine whether or not the measurements are provided by faulty sensors. State estimation is to estimate the states of moving objects from measurements with random measurement noise or disturbance, which typically consist of their positions and velocities over …

The Family Affective Attitude Rating Scale In Children With Asthma: The Association Between Relational Schemas And Emotional Security, Jessica L. Greenlee

Theses and Dissertations

The Five Minute Speech sample is a cost effective, efficient means of data collection in developmental research, but recent criticism of traditional coding methods associated with the methodology has spurred the creation of more developmentally appropriate coding systems. The purpose of this study is to examine the reliability and validity of a new coding system, The Family Affective Attitudes Rating Scale (FAARS), for use in children with chronic illness. Results did not support the use of this coding system, at least in its current form, in a pediatric asthma population. Discussion focuses on whether the FAARS may be of use …

Examining Ptsd Symptoms And The Effectiveness Of Group Therapy Among African American And Caucasian Veterans, Jennifer A. Coleman

Theses and Dissertations

Millions of Americans have served in the military, and improved survival rates in wars have increased the percentage of those who return home. Posttraumatic stress disorder (PTSD) is one of the most prevalent mental health diagnoses for veterans. Although few studies have examined the link, previous research as well as the minority stress model and transgenerational trauma theories, suggest that race may be associated with PTSD, particularly in military samples. The current study examined whether there were differences in PTSD symptomology (global and symptom cluster-specific) based on veterans’ race and whether group therapy effectively reduced symptoms of PTSD. Data were …

Atm Phosphorylates Subunit A Of Pp2a Resulting In Its Nuclear Export And Spatiotemporal Regulation Of The Dna Damage Response, Amrita D. Sule

Theses and Dissertations

Ataxia telangiectasia mutated (ATM) is a serine-threonine protein kinase and major regulator of the DNA damage response (DDR). One critical ATM target is protein phosphatase 2A (PP2A) known to regulate diverse cellular processes such as mitosis and cell growth as well as dephosphorylation of many proteins during the recovery from the DDR while returning the cell to normalcy. Interestingly, ATM and PP2A are known to form an auto-regulatory yin-yang kinase-phosphatase relationship. Herein, we show that the phosphorylation of the PP2A-Aα structural subunit at S401 by ATM results in nuclear export, which regulates the DDR at multiple levels and affects genomic …

A Phenomenological Study: Foster Care Youth Aging Out Of The System, Guy Thompson

Theses and Dissertations

The purpose of this applied dissertation was to explore the lived experiences of teens aging out of foster care, in an effort to better understand their needs. While the child welfare system is geared towards family preservation, reunification, and adoption, most young adults transitioning from the foster care system are not reunited with family members or are only reunited as a last resort. Unfortunately, every year, thousands are leaving the support of the foster care system, unprepared. Youth departing the child welfare system are not gradually transitioned into becoming self-sufficient. They do not have an effective support system available if …

Social Worker Experiences Serving At-Risk Youth With Emotional And Behavioral Disabilities, Sherriese S. Anderson

Theses and Dissertations

This dissertation was a qualitative study of school social workers who worked with special needs adolescent youth with emotional and behavioral disabilities in a public high school. This study centered on the experiences of 10 social workers in a public high school in New Jersey. All 10 school social workers were interviewed individually to uncover (a) how they perceived the school social worker's role within the public school setting, (b) the lived experiences of school social workers who worked with special needs youth with emotional and behavioral disabilities, and (c) why they desired to continue working with at-risk special needs …

Integration Of Multispectral Camera Systems For Enhanced Visualization Biological Studies Using Uas, Subin Shahukhal

Theses and Dissertations

The purpose of this research is to enhance visualization of warm-blooded animals and analyze the vegetation in which they are located using a camera system mounted on Unmanned Aircraft System (UAS). The results are coherently displayed in a single image at the same spatial location so that biologists will have accurate animal counts along with vegetation conditions. Application of aerial imagery has been used to analyze the vegetation health and determining the number of the animals by the wildlife service. However, a major obstacle of the research is to combine the two imaging systems to obtain the same spatial image …

A Comparative Analysis Of Associate And Baccalaureate Degree Respiratory Therapy Programs' Preparation Of Graduates For Entry Into The Profession, Christine Sperle

Theses and Dissertations

The purpose of this study was to increase the understanding of the factors that contribute to or detract from the educational preparation of graduates between associate (AD) and baccalaureate degree (BD) respiratory therapy programs through the use of graduate and employer survey ratings, Registered Respiratory Therapist (RRT) credentialing success, and document analysis of various institutional and program mission, course content, and goals.

This study employed quantitative analyses to compare the perceptions of AD graduates and their employers with the perceptions of BD graduates and their employers regarding the educational program’s ability to prepare graduates for entry into the profession. Graduate …

Using Long-Short-Term-Memory Recurrent Neural Networks To Predict Aviation Engine Vibrations, Abdelrahman Elsaid

Theses and Dissertations

This thesis examines building viable Recurrent Neural Networks (RNN) using Long Short Term Memory (LSTM) neurons to predict aircraft engine vibrations. The different networks are trained on a large database of flight data records obtained from an airline containing flights that suffered from excessive vibration. RNNs can provide a more generalizable and robust method for prediction over analytical calculations of engine vibration, as analytical calculations must be solved iteratively based on specific empirical engine parameters, and this database contains multiple types of engines. Further, LSTM RNNs provide a “memory” of the contribution of previous time series data which can further …

Novelty Detection And Cluster Analysis In Time Series Data Using Variational Autoencoder Feature Maps, Sophine Clachar

Theses and Dissertations

The identification of atypical events and anomalies in complex data systems is

an essential yet challenging task. The dynamic nature of these systems produces huge volumes of data that is often heterogeneous, and the failure to account for this will impede the detection of anomalies. Time series data encompass these issues and its high dimensional nature intensifies these challenges.

This research presents a framework for the identification of anomalies in temporal data. A comparative analysis of Centroid, Density and Neural Network-based clustering techniques was performed and their scalability was assessed. This facilitated the development of a new algorithm called the …

Motivations In Exercise, Amanda Dufner

Theses and Dissertations

College students exercise for a variety of reasons, but specific differences in their motivations and perceptions have not been extensively studied. PURPOSE: The main purpose was to see if students whose primary reason for exercise is to lose fat (FATCON), gain muscle mass (MUSC), or maintain health (HLTH) had differences in their exercise motivations, social physique anxiety, and body image self-perceptions.

A secondary purpose was to explore if the participants’ supplement use reflected their exercise priorities.

METHODS: Data were collected at a university Wellness Center, or from exercise classes. Participants (N = 216) completed a packet of four questionnaires: Multidimensional …

Concealing Stigmatized Sexual Orientation, Accepting Versus Non-Accepting Attitudes, And Ego Depletion, Nicole Gigi Giordano

Theses and Dissertations

The current study was designed with the aim of increasing the understanding of

how concealing or disclosing a stigmatized sexual identity to a perceived accepting/non- accepting person affects ego depletion. Ego Depletion, (Baumeister, 1998) refers to the idea that certain tasks exhaust a limited pool of cognitive resources. Previous literature has explored how concealing a stigmatized identity is ego depleting; however, an examination of the relationship between ego depletion and the concealment of the specific identity as a sexual minority has not yet been explored. LGBQ individuals are often faced with the challenge of navigating social situations to determine if …

The Impact Of Trauma On Children’S Functioning And The Utility Of The Cbcl Ptsd Profile, Nicola Ashton Herting

Theses and Dissertations

The high rates of trauma exposure among children and adolescents is a major public health concern due to the many ways trauma can adversely impact cognitive, emotional, and social development and functioning. The high rates of comorbidity between posttraumatic stress symptoms (PTSS) and other mental health disorders translate to complex diagnostic pictures. When conducting psychological, educational, or neuropsychological evaluations it is therefore imperative that clinicians assess for trauma to accurately diagnose, but ultimately to ensure appropriate recommendations for treatment and interventions are made. Several challenges to screening and assessing PTSS among children and adolescents have prompted the identification of efficient …

The Protective Roles Of Primary And Secondary Control Strategies Among Familial Caregivers Of Older Adults With Dementia, Nicole Haverstock

Theses and Dissertations

Caring for an older family member with dementia can be extremely stressful, often resulting in diminished psychological health. Prior research has shown that a strong sense of control protects well-being during stressful times. Therefore, greater perceived control may serve to buffer the effects of stress on familial caregivers’ psychological health. According to control theorists (Heckhausen & Schulz, 1995; Rothbaum, Weisz, & Snyder, 1982), a general sense of control is maintained through a dual process involving direct attempts to change the environment (i.e., primary control strategies) and attempts to inwardly adjust cognitions to align with the environment (i.e., secondary control strategies). …

Effects Of Plant Community Structure, Soil Components, And Aboveground Fungal Presence On Grassland Productivity, Thomas Mckenna

Theses and Dissertations

This dissertation investigates how aspects of the resident plant community affect grassland productivity. Chapter One gives an overview of how grassland productivity can be affected by the structural components of a plant community, abiotic and biotic soil components, and the presence of aboveground fungi. In Chapter Two, I present results of an experiment where the frequency of interspecific interactions in plant communities was altered along richness and evenness gradients by either randomly placing species in plots (dispersed plots) or by aggregating species in groups of four individuals (aggregated plots). Results suggest aggregation decreased productivity by promoting species coexistence and not …

Avian Haemosporidian Parasites From The Brazilian Amazon, Jeffrey Andrew Bell

Theses and Dissertations

Birds possess the most diverse assemblage of haemosporidian parasites, including three genera, Plasmodium, Haemoproteus, and Leucocytozoon. Currently there are over 200 morphologically identified avian haemosporidian species, although the true diversity is unknown, due to high genetic diversity and insufficient sampling in highly diverse regions, such as the Neotropics. Brazil, specifically the Brazilian Amazon supports the world’s highest avian diversity and expected equally diverse yet undescribed community of avian haemosporidians. This study includes the largest sampling of avian haemosporidians in Brazil, and the first large scale survey of the Brazilian Amazon. A total of 4521 blood samples were collected from 447 …

Diagenesis And Reservoir Analysis Of The Birdbear Formation, Williston Basin, North Dakota, Sunny Ekwenta

Theses and Dissertations

The southwestern part of Birdbear Formation of the Williston basin is part of the three shelf-wide sedimentary cycles in the Devonian transgressive-regressive sequence rock deposit. It is bounded above by the Three Forks and below by Duperow Formation. The formation can be informally divided into an upper A zone and a lower B zone. The common rock types in the Birdbear are dolomites, limestone, and anhydrite as well as combinations of anhydrite limestone, and dolomite limestone that is mostly found in the upper zone usually at the contact between the Three Forks and the Birdbear. Hydrocarbon has been found in …

Development And Validation Of The Partners’ Approval Of Nonsexual Extradyadic Behaviors Scale, Lindsay Frances Kujawa

Theses and Dissertations

Despite the emergent norm in U.S. society for partnered individuals across all sexual orientations to possess both same-sex and cross-sex friends (Weis & Felton, 1987), and the relative complexity that comes with having friends who belong to the sex to which one is sexually attracted, the field is lagging in its ability to measure and better understand individuals’ attitudes about their partners’ engagement in the various behaviors of which these friendships are comprised. The existing scales of extradyadic behaviors are largely measuring individuals’ attitudes about engagement in sexual behaviors with cross-sex friends within the heterosexual population; therefore, they are inadequate …

Interactomics-Based Functional Analysis: Using Interaction Conservation To Probe Bacterial Protein Functions, J. Harry Caufield

Theses and Dissertations

The emergence of genomics as a discrete field of biology has changed humanity’s understanding of our relationship with bacteria. Sequencing the genome of each newly-discovered bacterial species can reveal novel gene sequences, though the genome may contain genes coding for hundreds or thousands of proteins of unknown function (PUFs). In some cases, these coding sequences appear to be conserved across nearly all bacteria. Exploring the functional roles of these cases ideally requires an integrative, cross-species approach involving not only gene sequences but knowledge of interactions among their products. Protein interactions, studied at genome scale, extend genomics into the field of …

Electrochemical Studies Of Cerium And Uranium In Licl-Kcl Eutectic For Fundamentals Of Pyroprocessing Technology, Dalsung Yoon

Theses and Dissertations

Understanding the characteristics of special nuclear materials in LiCl-KCl eutectic salt is extremely important in terms of effective system operation and material accountability for safeguarding pyroprocessing technology. By considering that uranium (U) is the most abundant and important element in the used nuclear fuel, measurements and analyses of U properties were performed in LiCl-KCl eutectic salt. Therefore, the electrochemical techniques such as cyclic voltammetry (CV), open circuit potential (OCP), Tafel, linear polarization (LP), and electrochemical impedance spectroscopy (EIS) were conducted under different experimental conditions to explore the electrochemical, thermodynamic, and kinetic properties of U in LiCl-KCl eutectic. The ultimate goal …

Forest Stand Structure And Primary Production In Relation To Ecosystem Development, Disturbance, And Canopy Composition, Cynthia M. Scheuermann

Theses and Dissertations

Temperate forests are complex ecosystems that sequester carbon (C) in biomass. C storage is related to ecosystem-scale forest structure, changing over succession, disturbance, and with community composition. We quantified ecosystem biological and physical structure in two forest chronosequences varying in disturbance intensity, and three late successional functional types to examine how multiple structural expressions relate to ecosystem C cycling. We quantified C cycling as wood net primary production (NPP), ecosystem structure as Simpson’s Index, and physical structure as leaf quantity (LAI) and arrangement (rugosity), examining how wood NPP-structure relates to light distribution and use-efficiency. Relationships between structural attributes of biodiversity, …

Sol-Gel Assembly Of Metal Nanostructures Into Metallic Gel Frameworks And Their Applications, Xiaonan Gao

Theses and Dissertations

The advent of nanoscience and nanotechnology has sparked many research forefronts in the creation of materials with control over size, shape, composition, and surface properties.^1,2 However, for most of the applications, nanoscale materials need to be assembled into functional nanostructures that exhibit useful and controllable physical properties. Therefore, numerous efforts on the assembly of nanoparticles (NPs) using organic ligands, polymers and polyelectrolytes have been reported.^3,4 However, the interactions between NPs are mediated by intervening ligands, which are detrimental to charge transport and limit the thermal stability. Hence, developing a new method to produce solid …

Potential Treatments For Malformation Associated Epilepsy, Olivia M. Bowles

Theses and Dissertations

Epilepsy has been previously attributed to either increased excitation or decreased inhibition. With this closed frame of mind, modern medicine has been unable to develop a permanent treatment against the mechanisms of epilepsy. In order to treat patients with intractable seizures, especially those caused by developmental malformations, it is essential to understand the entirety of mechanisms that could possibly play a role in the abnormal cortical function. One such developmental malformation is known as polymicrogyria. Epileptogenesis occurs in an area laterally adjacent to this malformation known as the paramicrogyral region (PMR). Past studies have narrowed down the potential cause of …

A Correlational Analysis Of Secondary Data For Factors Influencing Graduation From Adult Drug Court, David N. Masri

Theses and Dissertations

The proliferation of drug courts throughout the world over the last two decades presents an opportunity and a challenge. The drug court approach involves a combination of treatment and judicial supervision which is a diversion from incarceration and/or ‘traditional’ criminal justice supervision. Despite widespread study of drug courts, there is much that researchers still do not know and there is still controversy as to how and why drug courts work. This research study is an examination of secondary data from an urban, mid-Atlantic drug court to attempt to correlate factors that contribute to success (as defined by graduation) in drug …