Digital Commons Network^™

Synthesis And Characterization Of Medicinally Privileged Aza Heterocycles, Nneoma James

Theses and Dissertations

Four-membered cyclic amides, commonly known as β-lactams, have played a crucial role in drug discovery research since its discovery by Alexander Fleming in 1928 from Penicillium notatum. The β-lactam antibiotics are broadly effective against several bacterial infections through acylating the transpeptidase involved in cross-linking peptides to form peptidoglycan or periplasmic murein, which is a fundamental constituent of the bacterial cell wall for both the gram-positive (ten or more layers) and gram-negative (one or two layers) bacteria. Although for more than eight decades, β-lactams have been recognized as antibiotics, later, other medicinal activities of β-lactam derivatives have been reported, including lowering …

Chemical Investigation Of The Ethanol Extract Of Tillandsia Usneoides (Spanish Moss), Jakir Hossain

Theses and Dissertations

Tillandsia usneoides in epiphytic bromeliads takes up water through absorptive trichomes on the shoot surface under extreme environmental conditions. Although previous studies revealed the way by which T. usneoides absorbs water and prevents water loss, its water transport remains unclear. Uses of T. usneoides L. have been documented going back to pre-Columbian and late archaic societies. Between the 1800s and 1900s. T. usneoides was utilized in fruit packing and polish, among other industrial goods. In terms of medicine, tillandsia is well-known for treating leucorrhea, rheumatism, ulcers, hemorrhoids, and as an anti-diabetic, emetic, analgesic, purgative, antispasmodic, and diuretic. The chemical composition …

Evaluating Pressure Distribution Of Surgical Support Surfaces For Pressure Injury Prevention: Small-Cell Alternating Pressure Mattress, Standard Foam Mattress, And Gel Overlay, Victor Moreno Lozano

Theses and Dissertations

Pressure injuries are a significant problem in the health care system for patients undergoing long surgeries due to the prolonged time they spend on the surface without moving under the anesthesia effect [6]. This can lead to the occurrence of pressure injuries and can negatively affect patient outcomes and the healthcare system [3]. Current methods for preventing pressure injuries in the operating room include repositioning the patient, using sponges or small gel pads at pressure points, and the use of support surfaces [2]. There is not enough conclusive evidence that states that the use of support surfaces is effective in …

Encompassing ‘Himdag’ (Indigenous Way Of Life) To Address Cardiometabolic Disease In American Indian And Alaska Native Communities Through Research, Policy And Action, Heather Medicine Bear

Theses and Dissertations

Cardiometabolic diseases (CMD), encompassing conditions such as cardiovascular disease, diabetes, kidney disease and non-alcoholic fatty liver disease, present a significant health burden within American Indian and Alaska Native (AI/AN) communities. This dissertation, through the culmination of three products, including a scoping review, policy brief and strategic planning toolkit, seeks to understand and address CMD in tribal communities through an Indigenous lens. Product #1, Interventions for Cardiometabolic Health in American Indian and Alaska Native Communities: A Scoping Review, entails a thorough review of implemented CMD interventions targeting AI/AN communities to understand programmatic, clinical, and community-based prevention strategies. By synthesizing available evidence, …

Peer Mentoring Program For Refugee And Newcomer Children To Increase Resilience, Chloe Skyla Cooksey

Theses and Dissertations

The refugee and newcomer population faces many challenges as they arrive in their host country. Many individuals experience varying degrees of trauma in their country of origin. Trauma can lead to poor mental health outcomes and poor adjustment in host countries. Refugee children in particular may experience post-traumatic stress disorder, depression, and anxiety as a result of traumatic experiences. Children can be resilient when given opportunities to create relationships and gain confidence. These opportunities can be fostered through various avenues, one of which is the school environment. Refugee students can benefit from various supports provided to them in the school …

Psychotherapy Utilization And Outcomes Of Military Veteran-College Students And Student-Rotc Members Compared To Similar Nonmilitary College Students, Jacob Michael Christian Goetz

Theses and Dissertations

This study examines current trends of university counseling center (UCC) utilization among Reserve Officer Training Corps (ROTC) students and student-military Veterans, compared to their nonmilitary-minded peers at a large, private, western university. Given likely differences in the lived experiences between these three populations, research is needed to provide insight on the treatment needs of military-minded students. We examine counseling center data for ROTC (n = 88), Veteran (n = 93), and nonmilitary-minded (n = 16,268) students who presented for counseling services from 2014-2021. A matched sample was obtained from the dataset for some of the analyses. The three groups are …

Potential Value Of Brazzein-Yeast As A Broiler Chicken Feed Additive, Lauren Ruth Neuleib

Theses and Dissertations

A variety of flavors, including sweeteners, have been used in animal feeds to improve feed palatability and increase feed intake by livestock (Chen et al., 2020). While many of these sweeteners are found in the form of carbohydrates, brazzein is a sweet-tasting protein. This study was conducted to identify the potential of brazzein to influence feed intake by livestock, using poultry as a model. The preliminary study's purpose was to develop methods appropriate for the subsequent feeding study. In the preliminary study, eight pens of five birds were fed one of four treatment diets: Control or the Control plus one …

Student Stress In Animal Science, Jayden Lynn Lawrence

Theses and Dissertations

Anecdotally, college students have high levels of stress when compared to the rest of the population. There have been many studies that support this idea in programs outside of animal science, but with the shift in animal science from students that have prior livestock experience to those that do not, it is important to acknowledge how this shift impacts the student population. By evaluating courses in animal science, and how they impact student stress it is possible to determine if the present-day curriculum causes any additional stress on students that have less prior experience. In the United States, a majority …

Facets Of Neuroticism As Predictors Of Heart Rate Variability And Psychological Distress, Mikel Cressman

Theses and Dissertations

Heart rate variability (HRV) and personality are related to both physical and mental health outcomes. Previous research has found a relationship between neuroticism and distress while the findings on the relationship between neuroticism and HRV are mixed. Studying the facets of neuroticism may provide a more nuanced view of the effects of personality on HRV and distress. Previous research has suggested that the vulnerability facet of neuroticism appears to be uniquely related to the cardiovascular response to stress. This study's first hypothesis is that individuals with higher scores on the vulnerability facet will have lower heart rate variability. The second …

Development Of Anti-Fibrotic Agents For Potential Use In Glaucoma Filtration Surgery To Prevent Scar Formation, Nikhala Shree S

Theses and Dissertations

Glaucoma is the second leading cause of blindness with irreversible vision loss. It is marked by the degeneration of retinal ganglion cells, which results in optic nerve head damage. Intraocular pressure (IOP) is a prime risk factor of glaucoma controlled by various treatment regimens i.e., medication, laser, and/ or surgery. It is reported that longterm exposure to anti-glaucoma medications (AGM) may subtle the surgical success rate leading to postoperative fibrosis. Transforming growth factor beta (TGF-β) is a growth factor that plays an important role in the development of glaucoma and promotes fibrosis.

This study is aimed at developing peptides to …

They See Themselves In The Lesson: Leveraging Students’ Scientific And Cultural Insights Through The Cultural Biohealth Synergy Science Curriculum [Se Ven A Sí Mismos En La Lección: Aprovechando Los Conocimientos Científicos Y Culturales De Los Estudiantes A Través Del Currículo De Ciencias De Sinergia De Bio Salud Cultural], Miriam M. Ortiz

Theses and Dissertations

In response to the global crisis of type 2 diabetes prevalence, this dissertation investigated the impact of a culturally sustaining, health-centric science curriculum contextualized in type 2 diabetes. Using a case study methodology, it explored how the curriculum shaped math and science preservice teachers’ (PSTs) perceptions of science and how it can be taught and how prepared they felt to design and implement culturally sustaining, health-centric lessons. Four themes that emerged across both cases included: 1) connecting health, nutrition, everyday science, and culturally sustaining pedagogy through the CBSS curriculum, 2) connecting science to health and wellness concepts through the CBSS …

Development Of A Mechanical Boot For Prevention Of Deep Vein Thrombosis In Outpatients, Julian David Trevino

Theses and Dissertations

This work presents the development of a mechanical boot designed to prevent Deep Vein Thrombosis (DVT) in high-risk individuals such as those who have just had major procedures. DVT is a serious condition characterized by the formation of blood clots in the deep veins, particularly of the lower limbs, which can lead to life-threatening complications if not adequately addressed. The mechanical boot utilizes the principle of Continuous Passive Motion (CPM) to facilitate blood flow in the lower extremities, thereby mitigating the risk of clot formation. Through a combination of mechanical engineering, biomedical research, and user centered design, the project outlines …

An Examination Of Self-Identity In Relation To Smoking And Vaping In South Carolina, Jaron Hoani King

Theses and Dissertations

BACKGROUND

This dissertation examines self-identity in the context of smoking and vaping among adults in South Carolina (SC) using data from the 2023 SC Adult Tobacco Survey (n=1370). The conceptual model created to guide this dissertation is called the “Smoker and Vaper Behavior-Identity Model” and draws constructs from theoretical frameworks in health behavior and social identity theories. Behavior was defined as lifetime and past 30 day cigarette or e-cigarette use. Self-identity was defined by asking respondents with a history of cigarette or e-cigarette use “Do you consider yourself a smoker/vaper”, respectively.

METHODS

First, this study assesses the prevalence of mismatching …

Examining Risk Factors For Early-Onset Breast Cancer, Jennifer Grace Taylor

Theses and Dissertations

Introduction: There have been great advancements in screening and in the identifying of risk factors associated with breast cancer, however, there is a lack of information of these factors in women with breast cancer occurring under the age of 45, known as early-onset breast cancer (EOBC). EOBC is often found at later stages, negatively impacting young women’s careers, family planning, and mental health. Additionally, because of the health disparities that exist within the U.S. health care system, women belonging to racial and ethnic groups, specifically young Black women, tend to have poorer outcomes and higher mortality rates of EOBC …

Collegiate Student-Athlete Responses To The Covid-19 Pandemic, Alexa Jenny Chandler

Theses and Dissertations

Introduction: Exercise imposes a physiological stressor on the body which is amplified as training intensifies. Collegiate fall-sport student-athletes return after summer break (off-season) and have approximately two weeks of training (preseason) with coaching staff before competition begins. The 2020 fall season was preceded by a five-month period away from campus due to the timing of the coronavirus 2019 (COVID-19) pandemic. This also meant all commercial gyms and training facilities were closed, and student-athletes were forced to train with the resources they had at home. Upon return to campus, significant changes were made to practice and competition structures in attempt to …

Characterizing The Quorum Sensing (Qs) System In The Model Eukaryote Chlamydomonas Reinhardtii, Kirstin Donnette Cutshaw

Theses and Dissertations

Group behaviors in microorganisms are often regulated by low-molecular weight molecules that enable them to sense population density, a signaling system known as quorum sensing (QS). QS in prokaryotes has provided insight into the role ‘social’ behaviors play in the bacterial world and refined our models of virulence, bacterial motility, and more. While less common, similar behaviors are observed in certain fungi, primarily yeasts, in which QS controls cell morphology, biofilm production, and other phenotypes. We have recently pursued the potential for QS to be more broadly distributed among unicellular eukaryotes, which could significantly alter our understanding of social behaviors …

Using Unmanned Aircraft Systems (Uas) To Assess Body Condition Of Common Bottlenose Dolphins (Tursiops Truncatus Truncatus) In The Indian River Lagoon, Florida, Jessica Jane Provenzano

Theses and Dissertations

Common bottlenose dolphins (Tursiops truncatus truncatus) in the Indian River Lagoon (IRL) have experienced four Unusual Mortality Events (UMEs). This stock is considered immunocompromised and is routinely subjected to persistent anthropogenic stressors such as fishing gear entanglement, vessel strikes, contaminants, and harmful algal blooms. Previous body condition assessments of this stock have involved invasive capture-release examinations or subjective methods using lateral body images. To improve precision, we investigated the use of photogrammetry data collected from noninvasive unmanned aircraft systems (UAS) combined with models developed from capture-release data to estimate morphometric parameters and subsequently determine the body condition of …

Investigating Microbe-Plant Symbioses In Space, David Handy

Theses and Dissertations

As life has evolved on Earth, gravity has been a constant around which biological processes have developed, rather than a pressure that has been adapted to. As humanity ventures into space, we remove this constant and can observe a variety of changes in biological systems, such as bone loss in humans, stunted plant growth, or increased virulence in pathogens. The growing body of data shows that life adapts to spaceflight and microgravity in unique ways that, due to our limited understanding, can be difficult to predict. A particularly under-studied area is that of host-microbe interactions. Despite efforts to limit their …

Bracketed Assessments In Behavioral Gerontology: Evaluating Preference With Present And Absent Stimuli, Flavia Eduarda Del Castillo Troche

Theses and Dissertations

The present study evaluated the use of bracketed assessments to assess the activity preference of three individuals with dementia. The study proposed an alternative method to traditional stimulus preference assessments, to bridge the gap in behavior analytical literature within behavioral gerontology. Thus, bracketed assessments were conducted using two presentation methods, verbal plus visual presentation and verbal-only presentation. Results suggested that while participants showed consistency within low preferred activity selection in the bracketed assessment, variability was observed among participants’ preferences for high and moderate preferred activities. Both presentation methods yield similar selection results for one participant, however, the other two participants …

Examining Risk Factors For Early-Onset Breast Cancer, Jennifer Grace Taylor

Theses and Dissertations

Introduction: There have been great advancements in screening and in the identifying of risk factors associated with breast cancer, however, there is a lack of information of these factors in women with breast cancer occurring under the age of 45, known as early-onset breast cancer (EOBC). EOBC is often found at later stages, negatively impacting young women’s careers, family planning, and mental health. Additionally, because of the health disparities that exist within the U.S. health care system, women belonging to racial and ethnic groups, specifically young Black women, tend to have poorer outcomes and higher mortality rates of EOBC compared …

Variation In Sperm Competition Risk Reveals Genotype And Genotype-By-Environment Effects On Gene Expression Of Nuptial Gift Proteins In Decorated Crickets, Laura Rengifo

Theses and Dissertations

Although mating in sexually reproducing species is a necessity, male and female interests during and after mating may diverge, leading to a sexual conflict. In polyandrous systems, males benefit by monopolizing female reproduction, and have evolved manipulative traits to this end. This includes plastically increasing sperm allocation under a high risk of sperm competition, when females are likely to mate with additional males. However, less is known about plasticity in non-sperm components of the ejaculate. Nuptial gifts provisioned to females by males are a widespread sexual tactic in insects used by males to maximize sperm transfer. In decorated crickets, the …

Application And Development Of Ceragenins In Medical Device Coatings For Clinical Settings, Elliot E. Sherren

Theses and Dissertations

Hospital-acquired infections (HAIs) pose a significant and increasing threat to global health. One primary cause of this threat is increasing antibiotic resistance. As traditional antibiotics continue to grow less effective, there is an urgent need for novel antimicrobial strategies. This work explores the potential of ceragenins, also known as cationic steroid antimicrobials (CSAs), as a promising alternative to combat HAIs. Specifically, we investigated potential roles that CSAs can play in the context of multiple medical device coatings in healthcare settings. Ceragenins are synthetic mimic of antimicrobial peptides (AMPs) which exhibit broad-spectrum antimicrobial activity against many common pathogens that have been …

The Osteological Neutral Pose Of The Neck Of An Apatosaurine Sauropod Based On Virtual And Physical Models, Colin Don Boisvert

Theses and Dissertations

An array of sauropod taxa coexisted in Late Jurassic North America. How so many giant genera coexisted without competing for food is puzzling considering their potential metabolic requirements. One aspect of this question is neck posture, which has been much contested, both in terms of the intrinsic curvature of the neck and the resultant elevation of the head. Neck curvature is characterized by the Osteological Neutral Pose (ONP), wherein the intervertebral joints are in an undeflected state. This pose is crucial to understanding neck posture. The articulated series of presacral vertebrae 2-19 of an exceptionally well-preserved apatosaurine, BYU 18531, are …

Chromosome-Scale Assemblies And A Pangenome Reveal Ltr Repeat Dynamics As A Major Driver Of Genome Evolution In Chenopodium, Kate E. Jaggi

Theses and Dissertations

The genus Chenopodium, which comprises around 150 species globally, is characterized by its wide geographic distribution and ecological adaptability, particularly in temperate regions. Some species, such as Chenopodium quinoa and Chenopodium pallidicaule, have served as domesticated staple crops in the Andean region of South America for centuries, valued for their robust nutritional profile and adaptability to adverse environmental conditions. In contrast, wild Chenopodium species exhibit broad geographic distributions and diverse niche adaptations, functioning as reservoirs for beneficial traits, including disease resistance and climate hardiness, essential for enhancing domesticated crops through introgression and breeding efforts. However, taxonomic classification within the genus …

Deciphering The Microbial Fingerprint Of Covid-19: A Multi-Layered Exploration Of The Oral And Gut Microbiome Dysbiosis, Iman Mostafa Sultan

Theses and Dissertations

The impact of SARS-CoV-2 infection on the human microbiome remains a dynamic and intricate puzzle. This study delves deeper into this mystery by revisiting the oral and gut microbial compositions of 53 COVID-19 patients before and after viral clearance, alongside comparisons to 76 healthy individuals. Through a comparative lens, we have emploed two distinct differential abundance methods – DeSeq2 and ANCOM – while drawing upon the thorough SILVA database encompassing the full-length 16S rRNA gene. The analysis underscores the crucial role of a diverse methodological choir in microbiome research. In certain instances, the congruence between DeSeq2 and ANCOM may exhibit …

Evaluating The Influence Of Perfluorooctane Sulfonic Acid Exposure On Blood Glucose Levels: A Comprehensive Multiple Regression Analysis Considering Confounding Factors, Henry Mensah

Theses and Dissertations

Perfluorooctane sulfonate (PFOS) are widely used for industrial and commercial purposes and have received increasing attention due to their adverse effects on health. This thesis investigates the relationship between PFOS exposure and blood glucose levels, considering potential confounding factors. Regression analysis was conducted on a dataset comprising demographic, lifestyle, and biomarker data from a diverse population sample. Sex exhibited a significant role, with females demonstrating an 11.77% increase in blood glucose levels in response to PFOS exposure compared to males, supported by a p-value of 1.04 × 109. Body mass index (BMI) also played a pivotal role, revealing a 2.17% …

Unraveling The Nexus: Social Spending, Development, And Breaking The Cycle Of Poverty, Yasmin Shehata

Theses and Dissertations

This study examines the role of development, as indicated by the Human Development Index (HDI), in shaping the connection between social public spending on health, education, and social protection and poverty in terms of the poverty headcount ratio at $3.65/day (2017 PPP). Empirical analysis is used to this end, employing a panel dataset of 68 countries at varied stages of development over the period 1995-2021. The empirical model is estimated using the Fixed Effects Two-stage Least Squares (2SLS). It is also re-estimated using the Instrumental Variable Generalized Method of Moments (IV-GMM) and Limited Information Maximum Likelihood (LIML) to test the …

How Do The Entrepreneurial Motivations And Struggles Of Egyptian Women Entrepreneurs Challenge Existing Perspectives?, Salma Sherif

Theses and Dissertations

This paper examines ten profiles of Egyptian women entrepreneurs and compares their perspectives to the widespread and main arguments in the existing literature reviewed on the topic; mainly their entrepreneurial motivation and challenges. The paper reveals similarities and contradictions, and introduces different angles to perceiving both aspects. The researcher concludes that contextualizing entrepreneurial motivations can, therefore, disclose deeper dimensions to the subject matter, and as for the challenges, it can change their relative importance. For the primary data collection, the paper follows a non-probability sampling approach by applying a purposive sampling technique. Semi-structured, in-depth interviews were conducted accordingly. The women …

The Inflammatory Exposome Of Major Depressive Disorder In An Egyptian Sample, Reem Deif

Theses and Dissertations

Major depressive disorder (MDD) has been recognized as a global public health concern affect-ing the lives of 264 million people with increasing prevalence worldwide. Inspired by the expo-somic research, this study aims to investigate the dynamic and complex interplay between dif-ferent demographic, lifestyle, environmental factors and bimolecular factors that are potentially involved in the pathology of MDD in a sample of Egyptian adults living in Cairo. This is in an attempt to acknowledge the biological underpinnings of MDD without underestimating the role of environmental influences. The context of Egypt provides richness to the current study given the national transition from …

Unlocking Prosperity: The Role Of Icts In Alleviating Poverty In Middle East And Africa, Yousra Elnemr

Theses and Dissertations

Most countries in the Middle East and Africa region (MEA) have recently witnessed digital improvements despite the increase in poverty rates. This thesis investigates the potential relationship of Information and Communication Technologies and poverty reduction using annual unbalanced panel data for 21 MENA countries and 48 Sub Saharan African (SSA) countries from 1990 to 2022. By focusing on two primary ICT indicators representing ICT usage and access—internet penetration and mobile subscriptions— our research applies Fixed-Effects Two Stage Least Square (2SLS) economic model to explore their relationship with the poverty headcount ratio at the $2.15 per day international poverty line. The …