Digital Commons Network^™

Rest/Nrsf Is A Master Negative Transcriptional Factor For Neurogenic Program By Maintaining Stem Cell Quiescence In Adult Hippocampal Neurogenesis, Mostafa Nashaat Ahmed Abdelhamid

Theses and Dissertations

Adult neurogenesis occurs in two distinct regions inside the brain, the subventricular zone (SVZ) in the lateral ventricle and the subgranular zone (SGZ) of the dentate gyrus in hippocampus. Neural stem cells (NSCs) are controlled by several intrinsic and extrinsic factors that regulate their proliferation, survival and differentiation in the adult hippocampus. REST/NRSF is considered a master transcription factor that regulates hundreds of neuronal genes essential for neuronal fate decision. In this study, we address the role of REST/NRSF (RE1 silencing transcription factor/Neuro-restrictive silencer factor) in regulating adult neurogenesis in hippocampus.REST/NRSF has biphasic expression in neural stem cells and mature …

Using Culture Independent Approaches To Gain Insights Into Human Urinary Tract Microbiome In Healthy Male And Female Individuals, Sarah Hussein El-Alawi

Theses and Dissertations

Here we present comprehensive insights into the diverse collection of bacterial communities that indigenously inhabit the urinary tract of healthy adult male and female individuals using cultivation independent techniques. Several studies address the importance of uncultured microbial flora that inhabits the human urinary tract in health and diseases. Thus, a deep and accurate understanding of the factors influencing this ecological niche and its microbiome is important to prevent possible infectious diseases. Genomic DNA was extracted from midstream urine samples collected from 4 adult, healthy and culture-negative male and female individuals at ages ranging from 18 to 40. Following PCR amplifications …

A Descriptive Study Of Funded Homeless Education Programs: Barriers And Supports In New York State, Kerri A. Canzone

Theses and Dissertations

With the issue of homelessness ever-present in our educational system, it is important to examine current barriers and supports in the education of students experiencing homelessness. It is also critical to examine the academic achievement of this special population of at-risk students. Descriptive information was sought about types of barriers to education access and success, as well as supports and academic achievement in New York State-funded Local Education Agencies (LEAs) and to ascertain what educational leaders are doing to meet the educational needs of their homeless student population. Regional differences among barriers and supports were examined, as well as English …

Systematic Study Of Gene Functions For Morphological Chain Formation In Streptococcus Sanguinis, Karra Evans

Theses and Dissertations

Streptococcus sanguinis is a gram-positive facultative anaerobe that is indigenous to the oral cavity and a primary colonizer of the oral cavity. It serves as a tether for the attachment of several oral bacteria that colonize the tooth surface, form dental plaque, and cause periodontal disease. Previous experiments with streptococcal strains have suggested that cellular chain morphology of streptococci may influence the competitiveness, susceptibility to phagocytosis, acidurance, and aggregation of the bacterium. The purpose of this study was to systematically determine gene functions that contribute to cellular chain length morphology in the SK36 strain of S. sanguinis. Gene functions for …

Examination Of The Relationship Between Amercian Indian Cultural Identity And Academic Performance Of Nursing Graduates, Elizabeth Ann Yellowbird

Theses and Dissertations

There are great health disparities within the AI/AN population according to IHS documentation. Historical events such as complex political issues, poor education, boarding schools, and loss of language have heightened this difficult healthcare situation. Furthermore, issues such as lack of health professionals (especially AI/AN nurses) and access to healthcare services add to the dilemma. The cause for the low number of AI/AN nurses who graduate from college varies, but one significant area to consider is the relationship between poor academic performance influenced by cultural conflict. The purpose of this research was to examine the relationship between cultural identities of students …

A Study Of Early Childhood Education Teachers' Level Of Education, Compensation, Work Environment And Retention, M. Elida Garcia

Theses and Dissertations

This study examined Early Childhood Education (ECE) teacher job retention in the context of educational level, compensation, and work environment ratings. The study surveyed ECE teachers online in the Southern California, especially in Los Angeles County. Statistical analysis was conducted on survey responses from 76 ECE teachers and 55 ECE administrators. The majority of the ECE teachers (51%) possessed bachelor's degrees. Data findings revealed statistically non-significant relationships between anticipated job retention and teachers' level of education as well as for compensation earned. Study participants reported a mean monthly salary of $3,268. The data for ECE administrators, however, did reveal a …

Women's Social Networking: Steps That Organize Low-Technology Users With Emergency Needs, Jon O. Gary

Theses and Dissertations

The purpose of the study was for the researcher to develop and have evaluated the content, organization and ease of use of a computer-training program Emergency Response Quick Start book based on Information and Communication Technology environmental designs. This book was most notably based on underutilized women social networking traditions (food recipe/ meal preparation, and service). One research objective guided the development and evaluation of this training program: 1. This study provided an opportunity for a group of urban adults to evaluate, clarify, and test the ease of use of this computer-training program Emergency Response Quick Start book. The 14 …

An Untold Story: African American Women Founders Of Private And Charter High Schools, Sharon Wilson

Theses and Dissertations

The purpose of the study is to provide a leadership profile of selected African American (AA) women founders of private and charter high schools. To determine this profile, the research was designed to provide a defined exploration of the founders' leadership style, background, career, religious and ethical influences, entrepreneurship, community involvement, and their experiences with mentoring and helping traditions. This study also provides a demographic description of the schools they founded. This study details the untold story of a group of AA women who have affected the lives of many children. A literature review and adaptation of Yael Hellman's study …

A Systemic Perspective Of Stress In Emergency Medical Personnel: Emergency Medical Technicians And Firefighters, Rob W. Wennerberg

Theses and Dissertations

Emergency medical personnel (firefighters and ambulance personnel) have higher levels of lifetime PTSD symptoms than the general population. Historically this has been attributed to the number of exposures to traumatic incidents, called the dose effect, but recent literature has suggested that there is a complex web of variables that affect an individual's experience of trauma. Through an interpretive review of the literature this dissertation takes the concepts supported by empirical research and organizes them into an integrated theoretical structure. With ecological psychology at the core, the integration uses Living Systems theory as a structure with which to organize and explore …

An Autoethnographic Case Study Of A Manager Experiencing Professional Transition, Jean Ann Larson

Theses and Dissertations

This autoethnographic case study explores how one manager navigated a period of significant professional transition as a senior healthcare executive. The intent is to study how managerial leaders, which is Peter Vaill's (1996) definition of managers of people and organizations, can transition and develop behaviors and ways of thinking and being, in order to stay effective and learn and grow while experiencing significant changes. The study focuses on behaviors, practices and conditions that can be employed during times of transition in order to enable learning and professional development from the experience of transition. Using an autoethnographic approach, the case study …

Hiv Protease Inhibitors Trigger Lipid Metabolism Dysregulation Through Endoplasmic Reticulum Stress And Autophagy, Beth Shoshana Zha

Theses and Dissertations

HIV protease inhibitors (PI) are core components of Highly Active Antiretroviral Therapy (HAART). HIV PIs are extremely effective at suppressing viral load, but have been linked to lipodystrophy and dyslipidemia, which are major risk factors for cardiovascular disease. Recent studies indicate that activation of endoplasmic reticulum (ER) stress is an important cellular mechanism underlying HIV PI-induced dysregulation of lipid metabolism. However, the exact role of ER stress in HIV PI-associated lipodystrophy and dyslipidemia remains to be identified. Hepatocytes and adipocytes are important players in regulating lipid metabolism and the inflammatory state. Dysfunction of these two cell types is closely linked …

The Social Impact Of The American Civil War In The Western Theater Centering On Kentucky, Maurice L. Searcy

Theses and Dissertations

No abstract provided.

Cross-Language Transfer Of Phonological Awareness Skills In Preschool Spanish-English Bilinguals, Aileen Alvaro

Theses and Dissertations

No abstract provided.

Evaluation Of A Video-Based Training Program On Tutors' Implementation Of Discrete-Trial Teaching, Lindsay A. Deling

Theses and Dissertations

No abstract provided.

Indentification Of Novel Proteins Involved In Store Operated Calcium Entry, Jordan P. Karlstad

Theses and Dissertations

No abstract provided.

School Breakfast Program Participation In North Dakota, Linda Schloer

Theses and Dissertations

No abstract provided.

Listening To The Voices Of Preschool Aged Children Experiencing Homelessness: A Qualitative Approach, Maureen Turner

Theses and Dissertations

This exploratory, three phase qualitative research project gives a voice to preschool aged children experiencing homelessness to identify the significant relationships in their lives. Goals of this research included the exploration of: the central relationships of children experiencing homelessness, who children identify as important people in those relationships, how they describe those relationships, and how those relationships were formed. This research approach utilized a community participatory model in which the children's mothers contributed to the direction of the research project through group interviews. Children were observed for four months and then interviewed while completing three activities. The results suggested three …

Citizen Journalism And Digital Voices: Instituting A Collaborative Process Between Global Youth, Technology And Media For Positive Social Change, Robin Worley

Theses and Dissertations

Millions of youths in developing countries are described by UNICEF as "invisible and excluded." They live at the margins of society, facing challenges to their daily existence, powerless to make positive changes. But the emergence of citizen journalism and digital storytelling may offer these youths a chance to share their voices and positively impact their lives. The Internet and mobile devices have allowed ordinary citizens to become citizen journalists by sharing news when and where it happens with a global audience. Digital storytelling is also growing as a means of sharing one's personal story with a larger audience than ever …

Assessing The Impacts Of A Leadership Development Program On Skill Development And Organizational Performance, Gina Paone

Theses and Dissertations

The quality of an organization's leaders substantially influences organizational effectiveness (Bass, 1990. One way organizations seek to enhance the quality of their leaders is to conduct leadership development training. However, training and development does not automatically produce results (Cook, 2006). Too many organizations conduct training based on the implicit belief that it is beneficial, rather than upon quantifiable evidence. It is important to evaluate what tangible benefits actually can be associated with the training. This study assessed the impact of a leadership development program on one multinational organization, particularly as it concerned skill development and organizational outcomes. This study used …

North Dakota, A Land Of Opportunity Cost : An In Depth Look At The Factors Affecting High School Graduation Rates, Megan J. Jundt

Theses and Dissertations

No abstract provided.

How Husbands Can Support Their Wives In Achieving Weight Management Goals: The Development Of A Self-Help Resource, Christi Lynn Kush

Theses and Dissertations

The nationwide prevalence of obesity calls for more effective strategies for weight loss and maintenance of desired weight. The majority of weight loss programs focus on behavior change (diet and exercise) with some success, although lost weight is often regained. Interventions that boost the long-term effects of weight loss achievements are greatly needed. Marriage provides an ideal context for the lifestyle changes required for effective weight maintenance. Although well-intentioned, spouses may not know how to support their partner's weight loss efforts. Because women are more likely than men to attend to their spouses' health needs and women struggle more than …

“Clicked” Bivalent Multifunctional Ligands In Alzheimer’S Disease., Ronak Gandhi

Theses and Dissertations

Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by beta-amyloid (Aβ) aggregation/oligomerization, biometal dyshomeostasis, oxidative stress, and neuroinflammation. The multifactorial nature of AD may indicate the therapeutic potential of multifunctional ligands that tackle various risk factors simultaneously as effective AD-modifying agents. This notion is further supported by the fact that while numerous AD-modifying agents targeting one single risk factor have been developed and a number of them entered clinical trials, none of them has been successfully approved by the FDA. Furthermore, neuronal cell membrane/lipid rafts (CM/LR) have been demonstrated to associate with all the indicated risk factors, indicating that this …

Perceptions Of Five Low-Income Parents On School Readiness, Roanne Eugenia Malm

Theses and Dissertations

This small-scale qualitative study explored the perceptions of five low-income mothers regarding their child's readiness for kindergarten. The study has the potential to help early childhood advocates and other stakeholders (a) understand how low-income environments influence school readiness, (b) understand the aspirations low-income parents have for their children, (c) discover ways to improve the transition to school for economically disadvantaged children, and (d) engage parents in a more equitable manner--ultimately helping all children start kindergarten with success.

Parents selected for this study had a child age 4-5 who was the oldest child in the family, on a Head Start waiting …

The Effect Of Passive Stretching And Isometric Contractions On Delayed Onset Muscle Soreness After A Typical Bout Of Exercise, John W. Gibson

Theses and Dissertations

Delayed Onset Muscle Soreness (DOMS) is a common response to activities involving lengthening contractions. Muscle inflammation is associated with DOMS and may play an integral role in protecting a muscle from damage and soreness in response to subsequent bouts of lengthening contractions. Research in animals has shown that prior exposure to passive stretching and isometric contractions of a muscle resulting in muscle inflammation attenuates the muscle inflammatory response following subsequent bouts of lengthening contractions. The purpose of this study was to determine whether passive stretching and isometric contractions in humans would reduce DOMS following a typical bout of resistance exercise. …

African American Women's Health: An Examination Of Resource Needs, Context, And Public Policy Over The Life Course, Cynthia Newbille

Theses and Dissertations

African American Women's Health: An Examination of Resource Needs, Context, and Public Policy over the Life Course

The Effects Of Chronic Ampk Activation On Hepatic Triglyceride Accumulation And Glycerol-3-Phosphate Acyltransferaseactivity With High Fat Feeding, Mary E. Curtis

Theses and Dissertations

High fat feeding increases hepatic fat accumulation and is associated with hepatic insulin resistance. AMP Activated Protein Kinase (AMPK) is thought to inhibit lipid synthesis by the acute inhibition of glycerol-3-phosphate acyltransferase (GPAT) activity and transcriptional regulation via SREBP-1c. The purpose of this study was to determine if chronic activation of AMPK prevented an increase in GPAT1 activity in rats fed a high fat diet. Rats were fed a control (C), or a high fat (HF) diet (60% fat) for 6 weeks and injected with saline or a daily AICAR dose of 0.5 mg/g body weight. Chronic AMPK activation by …

The Relationship Between Diet Quality And Body Composition In College Women: A Cross-Sectional Analysis, Annette Elisabeth Perkins

Theses and Dissertations

Objective. Determine the relationship between dietary quality and body weight/composition in college women. Specific emphasis was made regarding adherence to current MyPyramid guidelines, fruit, vegetable and junk food consumption.

Design/Participants. The study used a cross-sectional design. One hundred and sixty three women were recruited to participate in the study. All participants were university students (20.4 ± 1.6 y). Diet intake was measured using the Dietary History Questionnaire (DHQ) and the Healthy Eating Index (HEI) was calculated to assess diet quality. Body fat percentage was assessed using the Bod Pod and BMI was calculated using height and weight measurements. Physical activity …

Nurse Anesthetist's Perceptions Regarding Utilization Of Anesthesia Support Personnel, Mary Ford

Theses and Dissertations

Anesthesia support personnel (ASP) provide direct support to health care providers administering anesthesia (Certified Registered Nurse Anesthetists [CRNAs] and anesthesiologists). Because these anesthesia providers are caring for a patient whom they cannot legally or ethically leave unattended, ASP are employed to bring them extra supplies or equipment, prepare equipment for the case, maintain and clean equipment, and generally function as directed by the anesthesia provider. Given the limited literature and importance of ASP in maintaining equipment essential to safe practice, it is necessary to describe the population to understand who is functioning in this role to insure that these individuals …

An Evaluation Of Cardiorespiratory Responses And Ventilatory Efficiency During Treadmill And Cycling Exercise In Overweight Adolescents, Amanda Scheps

Theses and Dissertations

The assessment of ventilatory efficiency (VE/VCO2 slope) is increasingly being utilized to complement traditional cardiorespiratory fitness testing during graded exercise. The purpose of this study was to compare cardiorespiratory responses and ventilatory efficiency in obese children during a progressive exercise test to volitional fatigue performed on a treadmill and a cycle ergometer. Fifteen obese male (N=3) and female (N=12) adolescents aged 10 to 18 years were recruited in the study and completed both the treadmill and cycle ergometer trials. Mean age and BMI of the sample was 13.3 years and 38.0 kg/m2, respectively. Maximal oxygen consumption (VO2max) and ventilatory efficiency …

A Meta-Analysis Of School-Based Childhood Obesity Prevention Programs, Ling Shen Hung

Theses and Dissertations

The prevalence rate of childhood obesity has increased rapidly worldwide. The childhood obesity epidemic is associated with many adverse health consequences in children as well as a financial burden for a nation’s economy. A meta-analysis was conducted to investigate the effectiveness of school-based childhood obesity prevention programs in preventing childhood obesity. The objectives of this study were to 1) identify the most effective childhood obesity prevention programs through effect size comparison, and 2) identify important program components that affect the effectiveness of the intervention through subgroup analysis. The Comprehensive Meta-Analysis (CMA) program was used for all statistical analyses. Results of …