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Parental Attitudes And Expectations Regarding Piano Study For Their Children With Autism Spectrum Disorder, Lin Zhong Oct 2025

Parental Attitudes And Expectations Regarding Piano Study For Their Children With Autism Spectrum Disorder, Lin Zhong

Theses and Dissertations

This study investigates parental attitudes and expectations regarding piano study for children with Autism Spectrum Disorder. Although music has been recognized for its therapeutic and educational benefits among individuals with ASD, research examining these outcomes from the perspective of parents has been limited. This study focuses on in-depth interviews with nine parents of children with ASD enrolled in the Carolina LifeSong Initiative, a specialized piano program serving students with diverse developmental disorders.

The interviews explored parents’ motivations for initiating piano study, expectations for both musical and non-musical outcomes, and observations of their children’s growth and challenges through music. Parents reported …


Evaluating The Performance And Feasibility Of A Device-Agnostic Approach To Compare Raw Accelerometry And Hr Data From Consumer Wearables To Research Grade Devices In Young Adults, Candy Bryan Mrudula Yalla Oct 2025

Evaluating The Performance And Feasibility Of A Device-Agnostic Approach To Compare Raw Accelerometry And Hr Data From Consumer Wearables To Research Grade Devices In Young Adults, Candy Bryan Mrudula Yalla

Theses and Dissertations

INTRODUCTION: Wearable technologies are increasingly used to monitor physical activity and heart rate in both research and everyday settings. This study aimed to compare accelerometery and heart rate (HR) data from two consumer wearables Apple Watch Series 7 and Google Pixel Watch Series 2, with research-grade devices: the ActiGraph GT9X Link and ActiHeart 5.

METHODS: Twenty-four young adults aged 18–24 years (mean age = 22.4; 54.2% female) participated in a 90-minute activity protocol while wearing the devices. The protocol included structured tasks ranging from rest to vigorous intensity. Consumer wearables and ActiGraph were worn on the non-dominant wrist, and the …


The Role Of Fibroblast Activation Protein On Left Ventricular Growth And Extracellular Matrix Remodeling As A Function Of Age And Pressure Overload, Amelia Marie Churillo Oct 2025

The Role Of Fibroblast Activation Protein On Left Ventricular Growth And Extracellular Matrix Remodeling As A Function Of Age And Pressure Overload, Amelia Marie Churillo

Theses and Dissertations

Fibroblast activation protein (FAP) is abundantly expressed in cancer associated fibroblasts and contributes to extracellular matrix (ECM) remodeling. Recent studies using imaging techniques have identified increased levels of FAP in the left ventricle (LV) of patients identified as at risk for developing heart failure. However, the role of FAP in regulated LV myocardial structure and function remains unclear. This project tested two hypotheses: First, genetic ablation of FAP would modify LV structure and function and be more pronounced with aging. Second, genetic ablation of FAP would modify LV structure and function with LV pressure overload (LVPO) accompanied by ECM remodeling.


Computational Analogies In The Era Of Large Language Models, Amarakoon Mudiyanselage Thilini Wijesiriwardene Oct 2025

Computational Analogies In The Era Of Large Language Models, Amarakoon Mudiyanselage Thilini Wijesiriwardene

Theses and Dissertations

Analogical reasoning is an important part of human cognition requiring the integration of abstract reasoning, pattern recognition, and background knowledge. Despite significant advances in language modeling, the capacity of current methods to accurately identify, model, and evaluate analogies remains fundamentally underexplored.

Analogies enable individuals to perceive deep similarities between superficially different situations. Effective analogy-making requires integrating knowledge about the external world with abstract reasoning and pattern recognition capabilities. While current language models (LMs), trained on massive textual corpora using autoregressive or masked objectives, achieve impressive performance across Natural Language Processing (NLP) tasks such as text generation, summarization, and classification, their …


Adapting To Inflationary Pressures: Household Coping Strategies In Urban Egypt (2016– 2025), Mohamed Mohamed Ashraf Kamal Oct 2025

Adapting To Inflationary Pressures: Household Coping Strategies In Urban Egypt (2016– 2025), Mohamed Mohamed Ashraf Kamal

Theses and Dissertations

Over the past decade, Egypt has faced persistent economic challenges including repeated currency devaluations, high inflation rates, subsidy reforms such as the gradual reduction of food and energy subsidies, and the ripple effects of global crises that have significantly impacted household well-being, especially in urban areas. These pressures have eroded purchasing power and heightened food insecurity, especially among low- and middle-income families. Although substantial attention has been paid to macroeconomic indicators, there remains a critical gap in understanding how households adapt on a daily basis to manage financial stress and sustain their livelihoods. This inquiry is especially timely, as household …


Deep Learning-Based Change Detection In High-Resolution Remote Sensing Imagery, Hazem Badawy Oct 2025

Deep Learning-Based Change Detection In High-Resolution Remote Sensing Imagery, Hazem Badawy

Theses and Dissertations

Remote sensing has become a key tool for monitoring Earth’s surface over time, offering valuable insights into both natural and human-driven changes. Among its many applications, change detection focuses on analyzing multi-temporal imagery to reveal how specific areas evolve across different time periods. It plays a pivotal role in Earth observation applications, including urban development monitoring, environmental degradation assessment, and disaster response. However, existing approaches often struggle with limited contextual awareness, high sensitivity to noise, and imprecise localization of change boundaries, especially with high-resolution imagery. This thesis investigates the complex problem of change detection in remote sensing imagery by proposing …


Addressing Climate Vulnerability And Policy Gaps Of Heat Waves In Upper Egypt: The Case Study Of Al-A’Qaab Village In Aswan, Eman Abdullah Oct 2025

Addressing Climate Vulnerability And Policy Gaps Of Heat Waves In Upper Egypt: The Case Study Of Al-A’Qaab Village In Aswan, Eman Abdullah

Theses and Dissertations

Heatwaves are currently one of the most dangerous climate hazards globally. Egypt is experiencing an increase in the intensity and frequency of heatwaves, which affects health, economy, infrastructure, and the ecological system. Upper Egypt is one of the most vulnerable regions in Egypt to rising temperatures, particularly in Aswan Governorate. The risks of heat waves are increasing vulnerability among vulnerable groups, such as women and low-income individuals. However, there is a clear gap in protection policies against heat waves, along with a lack of studies examining the effects of heat waves on individuals in Aswan. Accordingly, this thesis aims to …


Security And Terrorism Vs Free Expression: Analytical Study On The European Court Of Human Rights, Mariam Adel Massoud Sep 2025

Security And Terrorism Vs Free Expression: Analytical Study On The European Court Of Human Rights, Mariam Adel Massoud

Theses and Dissertations

The 11 of September attacks provide a paradigm shift when it comes to protection of national security. It results in a trending vision that prioritized security over national security, which makes it essential to think about balancing national security with free expression as a pillar of democratization. This study focusses on how the balance between freedom of expression and national security interests is achieved. It studies the legal approached of the European court of human rights and its legal assessment to strike this balance. The findings of this analytical study asserts that in order for the ECtHR to achieve this …


Addressing Graduation Disparities: Double-Dose Algebra As A Catalyst For Success Among Economically Disadvantaged Learners, Tracy Matozzo Sep 2025

Addressing Graduation Disparities: Double-Dose Algebra As A Catalyst For Success Among Economically Disadvantaged Learners, Tracy Matozzo

Theses and Dissertations

This study investigated the impact of a double-dose algebra intervention (DDAI) on the academic achievement of economically disadvantaged learners (EDLs) in a suburban New Jersey high school. Algebra, recognized as a gatekeeper course for graduation and postsecondary opportunities, was the focal point for targeted instructional reform. Using a quasi-experimental design, outcomes for EDLs enrolled in the DDAI were compared with peers in traditional algebra classes across three cohorts. Findings showed that EDLs in the treatment group achieved higher passing rates in Algebra I and demonstrated stronger attendance patterns than the control groups, though standardized test score improvements were modest. Survey …


Multiscale Modelling Of Eg5: Structural Insights Into Microtubule Interactions, Atp Hydrolysis, And Allosteric Inhibition Mechanisms, Soundarya Priya Alexandar Ms Sep 2025

Multiscale Modelling Of Eg5: Structural Insights Into Microtubule Interactions, Atp Hydrolysis, And Allosteric Inhibition Mechanisms, Soundarya Priya Alexandar Ms

Theses and Dissertations

The mitotic kinesin EG5 is essential for spindle bipolarity and accurate chromosome segregation during cell division, making it a validated anti-cancer target. Unlike conventional microtubule-targeting agents, EG5 inhibitors offer mitosis-specific action, reducing neurotoxicity. Although inhibitors targeting EG5’s allosteric site-I have been extensively studied, mechanistic insights into inhibition at site-II, and their combined effects, remain underexplored. This thesis systematically investigates the structural and dynamic mechanisms underlying EG5 function and its inhibition using an integrative computational approach.

Conformational analysis, coarse-grained dynamics, all-atom molecular dynamics simulations, and protein network analysis were performed on EG5 motor domain structures and EG5-microtubule complexes. Results show that …


Assessing Inclusion Within Naaee Affiliate Ee Associations And Where To Go From Here, Connor Chilton Sep 2025

Assessing Inclusion Within Naaee Affiliate Ee Associations And Where To Go From Here, Connor Chilton

Theses and Dissertations

Environmental Education (EE) has a history that has been typically defined by traditionally dominant identities (White, male, able-bodied, etc.). The North American Association for Environmental Education (NAAEE) offers a unique position as frontrunners for the field of EE and have the duty to provide an inclusive-minded education for and about the environments throughout the world. Through NAAEE’s affiliate network within the United States, this paper details a glimpse into the work towards inclusion by surveying its leadership position holders about the broad subject and several interconnections of inclusion. Upon completion of the survey, participants who opted to participate in a …


Ground-Based Modeling Of Deep-Space Risks To The Spleen And Intestine In Mice, Edith Nathalie Pineda Sotomayor Sep 2025

Ground-Based Modeling Of Deep-Space Risks To The Spleen And Intestine In Mice, Edith Nathalie Pineda Sotomayor

Theses and Dissertations

Deep-space missions, such as those planned for the cis-lunar space and Mars, pose unique challenges to astronaut health due to prolonged microgravity (MG) exposure and low-dose chronic irradiation (CIR). Understanding the impact of these stressors on secondary lymphoid tissues, such as the spleen and intestine, is crucial for ensuring crewmembers' well-being, given the impracticality of conducting this research with human samples. Using a ground-based facility, we exposed C57BL/6 female and male mice to CIR (1.74 Gy at a dose rate of 0.0029 Gy/h) and/or simulated MG (SMG) via hind limb unloading (HLU) for one month. Spleen and intestinal tissues were …


Creating A Classroom Environment For Prekindergarten Students To Develop Social-Emotional Competencies And Transition Out Of The Step Program., Ayeshah N. Major Sep 2025

Creating A Classroom Environment For Prekindergarten Students To Develop Social-Emotional Competencies And Transition Out Of The Step Program., Ayeshah N. Major

Theses and Dissertations

This mixed-methods study examined how the integration of Conscious Discipline and SEL-focused children’s literature can support the development of social-emotional competency in prekindergarten students. The problem of practice is that some children enter school without the foundational social-emotional skills necessary for successful learning and positive peer interactions. The purpose of this study is to identify strategies that support social-emotional growth and create an environment that aids STEP students in transitioning to a traditional prekindergarten classroom. Data was collected using parent questionnaires, student assessments, classroom observations, student interviews, and student drawings. The findings revealed that children’s literature provided accessible and meaningful …


Depression-Related Impairment During The Transition To College: Informing Prevention Efforts Using A Prospective Cohort Study, Nicole A. Kelso Sep 2025

Depression-Related Impairment During The Transition To College: Informing Prevention Efforts Using A Prospective Cohort Study, Nicole A. Kelso

Theses and Dissertations

Depression is a major public health concern in higher education. With college mental health counseling centers struggling to meet the high demand for services, there is a critical need to refine and expand prevention efforts. The first semester as a new postsecondary institution may be an important window for prevention efforts as students are adjusting to new academic and social challenges. This dissertation has three primary aims. Study 1 aims to improve identification of students in greatest need of preventive care and allocation of limited prevention resources. Study 2 seeks to refine understanding of etiological processes contributing to depression during …


Punitiveness In The Modern Era: Gender Roles & Anti-Transgender Attitudes, Haley Brooke Trantham Sep 2025

Punitiveness In The Modern Era: Gender Roles & Anti-Transgender Attitudes, Haley Brooke Trantham

Theses and Dissertations

Public opinion on punitiveness is an important topic of study because it can influence political elites’ decision making when developing legislation. This study focused on the role gender ideology and anti-transgender attitudes on punitiveness while controlling for religious and political conservatism. The 2020 American National Election Study (ANES) was used to examine the association between conservatism, traditional gender roles, and anti-transgender attitudes on their influence of punitiveness. Three ordinal logistic regressions were run for each type of punitiveness (i.e., death penalty support, crime spending, and felon disenfranchisement). Results indicated that religious conservatives had lesser odds for supporting the death penalty …


Detecting Electrical Submersible Pump (Esp) Failures And Estimating Run Life Using Artificial Neural Networks, Mostafa Ahmed Sobhy Sep 2025

Detecting Electrical Submersible Pump (Esp) Failures And Estimating Run Life Using Artificial Neural Networks, Mostafa Ahmed Sobhy

Theses and Dissertations

Electric Submersible Pumps (ESPs) are one of the important artificial lift methods for sustaining production in mature and high-water-cut wells; but may suffer frequent failures due to mechanical, electrical, hydraulic, chemical, and operational failures. These failures can yield substantial deferred production and intervention costs. Plenty of ESP installations are fitted with downhole sensors. Yet, it is observed that the current industry practice underutilizes the wealth of available sensor and operational data and lacks standardized, explainable failure-type identification and classification.

In this thesis, a comprehensive Machine Learning (ML) and Deep Learning (DL) framework was introduced for ESPs that simultaneously estimates remaining …


An Investigation Of Sex-Specific Effects Of Nucleus Accumbens Dopamine Receptor Signaling In Persistent Reward Seeking Under Punishment, Anna Caroline Toburen Sep 2025

An Investigation Of Sex-Specific Effects Of Nucleus Accumbens Dopamine Receptor Signaling In Persistent Reward Seeking Under Punishment, Anna Caroline Toburen

Theses and Dissertations

Addiction involves persistent reward-seeking behavior despite adverse outcomes, with the nucleus accumbens (NAc) critically mediating motivation and cost-benefit decision-making. Dopamine (DA)-responsive neurons in the NAc, specifically D1 and D2 receptors within the NAc are crucial in encoding motivated behavior. However, the specific role of D1/D2 receptors in driving reward-seeking under punishment remains unclear. Preliminary findings suggest a sex-specific effect, with females exhibiting greater sensitivity to the suppressive effects of footshock on natural reward-seeking compared to males. We investigated the differential roles of NAc D1/D2 receptors in modulating reward-seeking behavior under punishment, with a focus on potential sex-specific effects. Using a …


Bartók’S Romanian Folk Dances: A Consideration Of Sound And Movement, Bailey Frame Sep 2025

Bartók’S Romanian Folk Dances: A Consideration Of Sound And Movement, Bailey Frame

Theses and Dissertations

Béla Bartók (1881-1945) cared deeply about authenticity in his work. He continually passed by derivative versions, and instead sought the oldest, earliest, most inaugural version of each folk tune to use as that launching point for his compositions. As he collected the Transylvanian folk tunes that would become his Romanian Folk Dances, he disregarded inconveniences like bad weather and exhausting travel, and he doggedly lugged with him a newly invented Edison phonograph. Though it was unwieldy and fickle, the device allowed him to capture folk music in the moment it was created. Not one for sterile auditoriums or music studios, …


Examining The Role Of The M1 Motif Of Abcr1 Srna In Agrobacterium Tumefaciens, Daniel Arango-Cardona Sep 2025

Examining The Role Of The M1 Motif Of Abcr1 Srna In Agrobacterium Tumefaciens, Daniel Arango-Cardona

Theses and Dissertations

Agrobacterium tumefaciens is a gram-negative alphaproteobacterium that is one of the causative agents of crown gall tumors on plants. Its ability to transform plants using its T-DNA has been studied to improve plant-mediated transformation. sRNAs are small regulatory RNAs that play a role in gene expression in a variety of organisms and bind to target proteins or mRNAs. A. tumefaciens contains two sibling sRNAs, called AbcR1 and AbcR2, which are conserved among alphaproteobacteria. A. tumefaciens AbcR1 and AbcR2 are closely related, exhibiting 69% sequence identity, similar secondary and tertiary structure, and a conserved motif, M2, believed to direct target interactions. …


Automation Of Lcmc Logistics Processes: A Delphi Approach, Kline M. Alt Sep 2025

Automation Of Lcmc Logistics Processes: A Delphi Approach, Kline M. Alt

Theses and Dissertations

As the U.S. Air Force confronts growing complexity in system acquisition, the implementation of digital models in system design and logistics process management allows the incorporation of digital tools and the possibility for automation of portions of logistics processes. This thesis investigates where these technologies can be most effectively integrated within the Air Force Life Cycle Management Center logistics enterprise (AFLCMC). Using a three round Delphi study, AFLCMC logistics subject matter expert (SME) opinions were solicited from program-level senior logisticians, program managers to identify high-need areas, key success factors, and potential barriers to adoption. Quantitative consensus from Likert-scale and ordinal …


Impacts Of Climate Disruption On Mobility Aircraft Performance In The Pacaf Region, Hannah M. Dauterman Sep 2025

Impacts Of Climate Disruption On Mobility Aircraft Performance In The Pacaf Region, Hannah M. Dauterman

Theses and Dissertations

This thesis investigates the projected impacts of climate disruption on the performance and fuel management of the C-17 Globemaster III, a critical mobility aircraft in the Pacific Air Forces (PACAF) region. As rising global temperatures reduce air density, the performance of aircraft is compromised, resulting in increased fuel consumption, as well as the potential for extended runway requirements and diminished cargo capacity. Using climate projection data from Coupled Model Intercomparison Project Phase 6 (CMIP6), this research analyzes future air temperature trends and their implications for C-17 fuel consumption. Results suggest that by 2049, the U.S. Air Force may incur an …


Multi-Fidelity Machine Learning Modeling For Aerodynamic Response Prediction Of Aerospace Vehicles, Ethan S. Jackman Sep 2025

Multi-Fidelity Machine Learning Modeling For Aerodynamic Response Prediction Of Aerospace Vehicles, Ethan S. Jackman

Theses and Dissertations

Hypersonic vehicle design requires understanding complex aerodynamic phenomena across the full flight regime. This study presents a novel MF surrogate modeling methodology that enables the prediction the full field response across a vehicle’s surface. A Space-Filling Curve (SFC) is used to convert unstructured data into 1D vectors. The a Convolutional Autoencoder is used with transfer learning to reduce the dimensionality of the data. An Emulator-Embedded Neural Network (E2NN) combines multi-fidelity data for fast, accurate predictions. A benchmark analytical example and hypersonic application are used to evaluate the methodology. Using various numbers of samples and sampling strategies it is found that …


Effect Of Workplace Design On Collaboration And Satisfaction In Space System Command, Joshua A. Hagood Sep 2025

Effect Of Workplace Design On Collaboration And Satisfaction In Space System Command, Joshua A. Hagood

Theses and Dissertations

This study addresses a significant knowledge gap regarding the influence of physical workplace design on employee collaboration and satisfaction with the physical environment within U.S. Space Force technical military organizations.  While seminal industry research consistently demonstrates that physical design and indoor environmental quality influence employee satisfaction and collaboration (e.g., Candido et al., 2015; Sailer et al., 2021), the understanding of these impacts within military contexts remains limited.  Using a quantitative post-occupancy evaluation survey, adapted from the Sustainable Post Occupancy Evaluation Survey (SPOES), multiple regression analyses revealed that physical elements collectively predict both satisfaction and collaboration.  The final simplified model showed …


A Review Of The United States' Long Term War Support Capabilities In The Indo-Pacific Command Region, Brian J. Mullin Jr. Sep 2025

A Review Of The United States' Long Term War Support Capabilities In The Indo-Pacific Command Region, Brian J. Mullin Jr.

Theses and Dissertations

This study examines U.S. maritime transportation readiness in the Indo-Pacific, highlighting fleet age, mariner shortages, shipyard decline, and port vulnerabilities. It also considers contested logistics and technological threats. Recommendations include fleet recapitalization, mariner pipeline growth, port diversification, and defensive upgrades. The study concludes that secure sea line assumptions are outdated and calls for greater resilience, with follow-on efficiency analysis proposed for ports and ships.


An Antioxidant Approach To Ameliorate The Effects Of Radiation And Chemotherapy On Cognition, Raymond Anan Otoo Aug 2025

An Antioxidant Approach To Ameliorate The Effects Of Radiation And Chemotherapy On Cognition, Raymond Anan Otoo

Theses and Dissertations

Acute Lymphoblastic Leukemia (ALL) is a hematologic malignancy that primarily affects children and young adults. While advancements in treatment—including chemotherapy and cranial irradiation—have significantly improved 5-year survival rates in children to nearly 90%, radiation-induced cognitive impairment (RICI) remains a persistent and debilitating side effect. The brain, particularly the hippocampus, is highly susceptible to radiation-induced oxidative stress and inflammation. In the treatment of ALL, the combined use of chemotherapy and radiotherapy contributes to a heightened oxidative burden, exacerbating the risk of cognitive dysfunction. Although previous studies have linked radiation exposure to neurocognitive decline, the molecular mechanisms underlying RICI and chemotherapy-induced cognitive …


The Relationship Between Effort Cost Decision Making, Consummatory/Anticipatory Pleasure, And Health Behaviors In Schizotypy, Adriann Lai Aug 2025

The Relationship Between Effort Cost Decision Making, Consummatory/Anticipatory Pleasure, And Health Behaviors In Schizotypy, Adriann Lai

Theses and Dissertations

Motivational and hedonic deficits are not well studied in schizotypy as they relate to health behaviors. Nonclinical undergraduate participants (n= 247) completed self-report measures and a behavioral task (EEfRT) that assessed effort cost decision making. Social anhedonia was positively associated with increased effort but simultaneously reduced responsiveness to increasing rewards, indicating inefficient effort allocation. Consummatory pleasure was the more relevant hedonic predictor of effort, rather than anticipatory pleasure. In exploratory analyses, higher positive schizotypy scores were significantly associated with greater consummatory pleasure, while disorganized schizotypy was unrelated to pleasure indices or effort performance. In secondary hypothesis analyses, all schizotypy traits …


Rethinking The Red Zone: Risk Factors Of College Student Dating Violence Victimization During The Fall Semester, Alexandra Nicoletti Aug 2025

Rethinking The Red Zone: Risk Factors Of College Student Dating Violence Victimization During The Fall Semester, Alexandra Nicoletti

Theses and Dissertations

College students experience dating violence (DV) victimization at alarmingly high rates, which is associated with a variety of negative outcomes (Brewer & Thomas, 2019; Choi et al., 2017; Leemis et al., 2022). To implement effective prevention programming, it is important to understand the risk factors associated with DV victimization on college campuses. Further, college students report the highest rates of one type of DV victimization—sexual victimization—during the fall semester, also known as the “red zone” (Carey et al., 2018, Cranney, 2015). This study utilized the socioecological model to understand which individual-, relationship-, and community-level risk factors were associated with DV …


Development Of Novel Small Molecules As Potential Anti Cancer Agents, Robert John Chitren Aug 2025

Development Of Novel Small Molecules As Potential Anti Cancer Agents, Robert John Chitren

Theses and Dissertations

This doctoral thesis explores the discovery and characterization of two novel small molecules, designated as KS100 and (R,S’)-MNF, with potential anti-cancer properties. The study encompasses a comprehensive investigation into the molecular mechanisms underlying the anti-cancer effects of these compounds, as well as their therapeutic potential in preclinical models. These findings highlight the potential of KS100 and (R,S’)-MNF as lead candidates for cancer therapy, paving the way for further preclinical development and clinical translation.


Cultivating Climate And Culture: New Jersey Principals' Use Of Sel In Pk-12 Schools, Michelle Papa Aug 2025

Cultivating Climate And Culture: New Jersey Principals' Use Of Sel In Pk-12 Schools, Michelle Papa

Theses and Dissertations

The purpose of this qualitative, intrinsic case study is to explore how PK-12 principals in New Jersey perceive their approaches to leadership through their own social and emotional learning (SEL). With growing demands placed on school leaders, the study examines how principals integrate the five SEL competencies (self-awareness, self- management, social awareness, relationship skills, and responsible decision-making) into their leadership practices to positively impact school climate and culture. Through semi- structured interviews and document analysis, ten principals revealed that SEL is not only essential for student and staff well-being but also central to their own leadership development. Findings indicate that …


Analytical Characterization Of Artemisinin And Its Derivatives Using High Performance Liquid Chromatography, Electrochemistry Reduction, And Fluorescence, Faraja Ombwayo Aug 2025

Analytical Characterization Of Artemisinin And Its Derivatives Using High Performance Liquid Chromatography, Electrochemistry Reduction, And Fluorescence, Faraja Ombwayo

Theses and Dissertations

Artemisinin and derivatives were subjected to 37°C and room temperature conditions. When HPLC-UV analysis of both conditions was performed, there were differences in both conditions which suggested that artemisinin and derivatives degrade at 37°C. When artemisinin was electrochemically reduced, new peaks were generated and LC-MS analysis of the reduced artemisinin indicated that either new molecules or molecular reorganization was formed. These electrochemical reduction molecules (products) were deemed analogous to the artemisinin reduction occurring in-vivo after oral administration. Fluorescence analysis of artemisinin and derivatives were performed in the presence of dipyridamole. Dipyridamole intensity was observed to decrease when artemisinin or its …