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Parent Perspectives On Barriers And Facilitators To Optimal Healthcare And Medical Screenings For Children With Down Syndrome In South Carolina, Vinita Oberoi Leedom

Theses and Dissertations

Children with Down syndrome (DS) often have co-occurring conditions affecting vision, hearing, sleeping, and more. Screenings, as recommended by the American Academy of Pediatrics (AAP), can help prevent secondary disability, and allow children to thrive. Studies have evaluated the receipt of recommended screenings, but barriers and facilitators surrounding access to screenings and care have not been described.

Parents of 24 children with DS in SC were recruited through schools and family support groups. One-hour long interviews were conducted in English and Spanish. Information was collected on health, healthcare quality, respiratory concerns, pandemic effects, access to care, and knowledge about AAP …

Food Insecurity In Youth And Young Adults With Diabetes: Prevalence And Association With Health Behaviors, Lauren Helene Martini

Theses and Dissertations

Given the life-long impact of diabetes(1-5), it is important to engage in behaviors that promote health and wellness to delay or prevent negative health outcomes(3, 6-10). Despite this, youth and young adults with diabetes generally do not adhere to nutritional(11-17) or physical activity(18, 19) recommendations. In households experiencing financial difficulties, especially those who are having difficulty providing sufficient food to all of its members, adhering to recommendations may be even more difficult.

The purpose of this dissertation is to better understand and contextualize food insecurity among youth and young adults (YYA) with youth-onset T1DM and T2DM. The first aim addresses …

An Examination Of The Prevalence And Predictors Of Drugging Victimization And Drugging Perpetration In A National Sample, Amber Nicole Wallace

Theses and Dissertations

Objective: The current study sought to expand the understanding of the nascent phenomenon of drugging, the administering of a drug or alcohol substance to an individual without their knowledge or consent (Swan et al., 2017). Specifically, in this paper, the lifestyle-routine activities theory (L-RAT) is used as a framework to examine what factors may contribute to the occurrence of drugging. Prevalence rates of drugging victimization and drugging perpetration are examined by participant characteristics including gender, sexual orientation, and race/ethnicity, and by risk behaviors including illicit drug use, marijuana use, and binge drinking. Trait sensation seeking, which has been shown to …

The Risk Of Protection: Examining The Contextual Effects Of Child Protective Services On Child Maltreatment Fatalities In The U.S., Cosette Morgan Mccullough

Theses and Dissertations

Much research has been done in the field of child homicide. While child homicide is a statistically rare event, it is especially pervasive in the United States. A subsection of research in the child homicide literature is the topic of child maltreatment fatalities, defined as when a child is killed through the means of maltreatment, such as physical abuse or neglect. What has been less so researched, however, is the combination of factors that can affect a child’s fatality risk. The current study seeks to expand on the previous research using the 2019 Child File of the National Child Abuse …

Racial Equity Analysis: Access To Permanent Housing And The Vulnerability Index – Service Prioritization Decision Assessment Tool (Vi-Spdat), Mary Ann Priester

Theses and Dissertations

Purpose: This study aimed to replicate and extend national research within the local context of the Charlotte-Mecklenburg Continuum of Care by using propensity score methods to examine the relationships between race, program outcome, and housing prioritization among subpopulations of individuals experiencing homelessness.

Methods: This study used secondary data analysis and propensity score methods to examine deidentified client-level Homeless Management Information System (HMIS) data collected from January 1, 2016 – December 31, 2021 by the Charlotte-Mecklenburg Continuum of Care (CoC).

Results: Findings indicate that Whites are more likely to exit homeless services programs to temporary or institutional destinations vs. permanent housing …

Multidimensional Transport-Coupled Numerical Investigation Of Non-Premixed Low-Temperature Flame In Atmospheric And High-Pressure Systems, Sudipta Saha

Theses and Dissertations

Gas-phase chemical reactions coupled with multidimensional fluid flow and heat and mass transport are found in various applications, i.e., from conventional engine applications to novel combustion techniques. With the goal of understanding such complex coupling in reacting flow systems, this dissertation work focuses on developing multi-physics simulation frameworks to investigate the effect of multidimensional transport on flame dynamics. This study primarily focuses on the modeling and simulation of low temperature flame formation in i) a canonical experimental setting with counterflow burners and ii) a supercritical water medium (i.e., hydrothermal flame).

In the first part of the dissertation, simulations of the …

Cashing The Check Of Democracy The American Revolution And Citizenship In The Black Freedom Struggle 1960-1970, Zachary Earle Clary

Theses and Dissertations

Separated into three interconnected parts, this thesis first proposes a reconfiguration of the vocabulary that historians use when classifying the memory and legacy of the American Revolution in the twentieth century. From there, I offer a comparative analysis of the Black Freedom Struggle’s relationship to the Declaration of Independence and other components of the American Revolution to demonstrate that the Revolution, while useful as a rhetorical tool or a conceptual model, functioned primarily as a counterpoint to the twentieth-century quest for Black citizenship. In other words, the American Revolution was a formidable example of radical protest in the American past, …

Detecting Spatially Varying Coefficient Effects With Conditional Autoregressive Models: A Simulation Study Using Social Determinants Of Health Screening Data, Reid J. Demass

Theses and Dissertations

Generalized linear models which include spatially varying coefficient terms allow researchers to determine if the association between predictor and outcome variables vary across geographic space. Such models are particularly applicable to research with public health data where interventions and limited health care resources must be allocated carefully. The integrated nested Laplace approximation (INLA) methodology available in the R INLA package is a popular tool to estimate spatially varying coefficients. To assess the performance of the estimation procedure, patient emergency department (ED) visits were simulated from data sourced from a pilot study at Prisma Health. The INLA technique was used to …

Sex Differentials In Frailty In Medieval Ireland, Allison Claire Ham

Theses and Dissertations

Population sex differentials in morbidity and mortality are influenced by genetic, hormonal, behavioral, and environmental mechanisms, and in the majority of living human populations, females experience longer lifespans and lower mortality risks, but paradoxically, greater morbidities compared to males. This dissertation project explored sex differentials in frailty (i.e., relative risk of death compared to others in the population) in medieval Ireland to address the existing temporal and contextual limitations for interpreting how far back the modern female health-mortality paradox extends. The project had three main objectives: examine sex differentials in mortality risks between the early (500-1100 CE) and late medieval …

Is There A Relationship Between Direct Patient Care Registered Nurses Emotional Intelligence And Patient Satisfaction?, James J. Leach

Theses and Dissertations

Many studies have examined Emotional Intelligence (EI) ’s role in various groups of people. However, to date, there have not been any studies examining the role of EI in direct patient care given by ICU nurses and the relationship between the nurses’ EI and patient satisfaction. With the importance of patient satisfaction tied to hospital reimbursement and the many approaches that have been made to improve patient satisfaction, studying the people (nurses) who spend the most time with the patient seems right. The data used for this study was obtained from an EI inventory for the nurses and an ICU-specific …

Aortopathies: Mechanism Of Pathogenesis And Therapy, Mengistu G. Gebere

Theses and Dissertations

The aorta is the largest artery in the body which is directly connected to the left ventricle of the heart and functions as an elastic conduit that transports the ejected blood from the left ventricle to peripheral vessels. There are three layers to the aortic wall, tunica intima, tunica media, and tunica adventitia. The tunica media, the thickest middle layer, is composed of vascular smooth muscle cells (SMC) and the extracellular matrix (ECM) as its essential components. SMCs are circumferentially arranged and embedded in elastic lamellae. They are responsible for producing and maintaining/remodeling the extracellular matrix of the aortic media. …

Targeting Macrophages In Cancer Models Using Natural Compounds, Sierra Jordan Mcdonald

Theses and Dissertations

Cancer remains a leading cause of death worldwide. More specifically, breast cancer (BrCa) and colorectal cancer (CRC) continue to be the most diagnosed cancers and leading causes of cancer-related death worldwide. Given that surgery followed by adjuvant chemotherapy is only effective in 20% of CRC patients, and that there are no preventive agents for BrCa metastasis for hormone receptor negative patients, more effective agents and strategies are needed in both the prevention and treatment of these cancers. As one of the most abundant immune cells in the tumor microenvironment, macrophages help regulate primary tumor growth, angiogenesis, and metastasis in many …

Bayesian Dependence Structure Analysis For Ordinal Data, Yang He

Theses and Dissertations

This dissertation explores different methods to study the dependence structure among many ordinal variables under the Bayesian framework.

Chapter 1 introduces ordinal data analysis methods, and the related literature works are briefly reviewed. An outline of the dissertation is put forward.

In Chapter 2, Gaussian copula graphical models with different priors of graphical Lasso, adaptive graphical Lasso, and spike-and-slab Lasso on the precision matrix are assessed and compared. The proposed models are well illustrated via simulations and a real ordinal survey data analysis.

In Chapter 3, adaptive spike-and-slab Lasso prior is proposed as an extension of Chapter 2. The developed …

Kurt Vonnegut, A Difficult Feminist: Investigating Female Characters In Bluebeard, Matthew Steven Medl

Theses and Dissertations

After a brief contextualization of Vonnegut’s work, this essay close-reads his 1987 novel, Bluebeard, and locates the feminism within. I argue that Vonnegut establishes women as agents of generative change, breakers of marital conventions, artistic sages, authors, expressionists, interlopers, and nonviolent activists. I primarily examine Circe Berman and Marilee Kemp, supplementing with evidence from Edith Taft and Dorothy, as well as wider scholarship.

Targeting Of Mediator Kinases For Cancer Therapy And Resistance Prevention, Zachary Thomas Mack

Theses and Dissertations

Estrogen receptor (ER)-positive breast cancers make up 70% of all breast cancer incidences in the US. Cell cycle progression of ER-positive breast cancer is highly dependent on cyclin-dependent kinases (CDK) 4 and 6, the G1/S checkpoint kinases. Inhibitors of CDK4/6 have become a major addition to the clinical arsenal against ER-positive breast cancers. CDK4/6 inhibitor palbociclib (IBRANCETM) has been approved for the treatment of ER-positive breast cancers. However, palbociclib treatment eventually fails due to the development of resistance. Laboratory studies revealed several diverse mechanisms of palbociclib resistance, making universal re-sensitization difficult to achieve. However, prevention of the adaptive process that …

Vaccinia Virus And Measles Virus As Oncolytic Vaccines: The Modulation Of The Viral Infectivity Via Surface Conjugations, Monchupa Kingsak

Theses and Dissertations

Oncolytic virus (OV) therapy has been shown to be an effective targeted cancer therapy treatment in recent years, providing an avenue of treatment that poses no damage to surrounding healthy tissues. Not only do OVs cause direct oncolysis, but they also amplify both innate and adaptive immune responses generating long-term antitumor immunity. However, a key challenge facing oncolytic virotherapy is neutralizing antibodies in vaccinated patients, leading to the viral clearance after systemic administration and failure in the treatment. The encapsulation of OVs using biocompatible polymers is one of the promising methods to prevent the viral clearance from antiviral immune responses. …

Biochemical, Structural, And Immunological Characterization Of Selected Panallergens, Andrea Leigh O'Malley

Theses and Dissertations

Allergies throughout the world are increasing in prevalence and severity. Although the direct causes of the development of allergies are not confirmed, study of proteins that cause reactions will lead to a deeper understanding of allergy. This work focuses on three panallergen families, profilins, parvalbumins, and arginine kinases, to further elucidate the background of allergy from the point of view of the allergens themselves. In Chapter 1, we evaluate pollen, fruit, and mite profilins in the context of allergy, showing the relevance of conserved cysteine residues in stability and oligomerization as well as the first data on cross-reactivity between plant …

Macroeconomic Determinants Of Stock Market Development In Sample African Economies, Ehab Ayoub

Theses and Dissertations

This research paper studies the relationship between macroeconomic determinants as independent variables and different measures of stock market development as dependent variables across selected emerging economies in Africa for the period of 2002 to 2021, with a quarterly frequency using time series analysis. The independent variables used are Core Inflation, Deposit Rate, Foreign Direct Investment (FDI), FX Rate against USD, Domestic Credit, Gross Domestic Product (Real GDP), Exports, Imports, External Debt, and Foreign Reserves. We use these variables as our main determinants of measuring economic growth. With regards to stock market development, we use four proxy measures as our benchmark, …

Mental Health And Well-Being Among Refugee-Aid Workers In Egypt, Mahmoud Khattab

Theses and Dissertations

Refugee-aid workers are positioned in the middle between the realities and suffering of refugees and the detachment of the organizations and their donors. They carry the burden of accommodating both realities as the connecting link between both worlds. This study has found that the continuous exposure to the traumatic stories that refugees go through has negative implications on the mental health and well-being of the workers providing services to these refugees. Additionally, a lack of resources and negative management cultures impose stress on the refugee-aid worker. Negligence and failure by organizations to mitigate these stressors lead to a deterioration in …

Substance Use Disorders And The Behavioral Effects Of Novel And Existing Compounds, Sarah Uribe

Theses and Dissertations

These investigations aimed to study the effects of experimental compounds for use in treating and preventing substance use disorders, particularly opioid use disorder (OUD) and alcohol use disorder (AUD). Identifying and testing potential medications for these two diseases is critical since current FDA-approved medications are only modestly effective, and addiction continues to spread. We previously demonstrated that co-administration of morphine and MP-III-024 produced synergistic effects in hot plate and von Frey assays. This study evaluated whether MP-III-024 also produced synergistic effects in behavioral tests sensitive to the side effects of morphine. Our findings suggest that co-administration of morphine and MP-III-024 …

The Impact Of Stress On Graduate Students’ Organizational Citizenship Behavior: The Moderating Role Of Mentorship, Victoria Garcia

Theses and Dissertations

Stress is one of the most researched topics in organizational psychology because of the important implications for overall health. Graduate school has many different stressors that put that specific population at a higher risk for the adverse effects of stress. Stress not only has implications for health but specific behaviors like organizational citizenship behaviors. The present study surveyed a sample of graduate students and examined ways in which mentorship can moderate the relation between stress, workload, physical symptoms, and OCBs. Eighty-five graduate students completed an anonymous survey. Results indicated that stress significantly predicted OCBs in graduate students. Also, mentorship was …

Thermal Inactivation Of Salmonella, Escherichia Coli, And Enterococcus Faecium Nrrl B-2354 In Pasta Matrices, Kristi Shannon Gowans

Theses and Dissertations

Limited data are currently available characterizing the thermal resistance of foodborne pathogens in semolina flour and intermediate pasta matrices representative of commercial conditions during mixing, extrusion, and drying. These data are essential to pasta producers seeking to be compliant with federal regulations since Salmonella spp. and Escherichia coli demonstrate survival in wheat flour and dried pasta products. This study investigated the heat resistance of Salmonella, pathogenic E. coli, and E. faecium NRRL B-2354 in raw semolina flour and partially dried pasta intermediates via thermal death time (TDT) studies. This study also assessed the appropriateness of E. faecium NRRL B-2354 as …

The Code Of The School: Investigating The Age At Which The"Code"Begins To Influence School Violence Among Students, Yoo Akakpo

Theses and Dissertations

The school-to-prison pipeline has sparked debate about disciplinary measures amongpolicymakers and school officials. Despite extensive research into student violence, there is little data on the age at which students start using violence in school. This study uses a critical qualitative analysis to determine what age or grade level students understand the importance of fighting, respect, and social status. I conducted the study's research in the Midwest, primarily focusing on students suspended after fighting in Chicago and Bloomington-Normal, Illinois. The Code of the School will be utilized as a theoretical basis to explore this qualitative study of African American students and …

Changes In Athletic Identity And Factors Influencing Change During Collegiate Sports Career, Lilla Kisvari

Theses and Dissertations

The purpose of this study was to examine and understand how athletic identity and life satisfaction changed in college student-athletes during their college careers and explore the factors that influenced the changes in athletic identity over time. Specifically, the three research questions were: (1) how does athletic identity, and its dimensions (social identity, exclusivity, and negative affectivity), and life satisfaction change in college student-athletes over a college career? (2) what are student-athlete perspectives on the factors influencing changes of athlete identity over a college career? And (3) what is the relationship between athletic identity and life satisfaction? The study included …

Losing Control To The Controller: Mmorpg Video Game Addiction And Mediating Roles Of Player Motivations, Abbie Speed

Theses and Dissertations

Using a quantitative survey distributed to regular players of MMORPGs (Massively Multiplayer Online Role-Playing Games) (N = 777), the current study employed a correlation matrix and a parallel mediation model to assess the relationship between play frequency, motivating factors, and video game addiction. The results demonstrated that each of these elements were related to one another to varying degrees (p < .001). The motivating factors identified by Yee (2006) included achievement, immersion, and social interaction, which were tested as mediators and indicated that achievement (a1 = 0.2817, p < 0.001; b1 = 0.4073, p < 0.001) and immersion (a2 = 0.3217, p < 0.001; b2 = 0.2574, p < 0.001) are mediators in the relationship of play frequency and addiction. Social interaction was not significant as a mediator (a3 = 0.3217, p < 0.001; b3 = -0.0235, p = 0.6753). Higher levels of addiction were present for those who were motivated by achievement (rewards) and immersion (storyline/diversion) to play more frequently per week. However, those who were motivated by social interaction to play frequently did not demonstrate a statistically significant relationship with higher levels of addiction. Findings suggest that motivating factors of gameplay may have a mediating effect on the relationship between play frequency and addiction.

Developing Tools For Introducing Modifications Into The Chicken Genome, Zachary Eldon Olsen

Theses and Dissertations

The chicken is a classic model organism that has provided key insights into embryonic development. Chicken embryos can be directly manipulated and observed during development while retaining the potential to reach adulthood. Despite this benefit, the utility of the chicken in studying development has been limited by the difficulty of introducing genetic changes to the genome. The recent development of cell culture conditions for chicken primordial germ cells (cPGC) has made it feasible to produce transgenic chickens, but there is still a lack of tools for introducing genetic modifications into cPGCs. Recombinase Mediated Cassette Exchange (RMCE) is a technique that …

Art Education As A Tool Of Feminist Resistance In Iran ( 1979-2022 ), Sedigheh Fathollahzadeh Dizaji

Theses and Dissertations

Art Education as a Tool of Feminist Resistance in Iran is a thesis that explores the use of art education as a form of resistance against patriarchy and gender inequality in Iran. Iran's historical and cultural background is examined in this study, along with the effects of the Islamic Revolution and the place of women in society. I interviewed Iranian female artists, art educators, and activists using an ethnographic research methodology to learn about their perspectives on using art education as a form of resistance. This research explores the various ways that art education can be a tool of resistance, …

"Love The Sinner, Hate The Sin"Does N'T Feel Like Love: Exploring Queer Former Catholics' Narratives Of Lived Experiences, Taylor Kay Newswander

Theses and Dissertations

The Catholic Church is one of the oldest and most widespread religious organizations in the world. Most people are familiar with the Church in some way, but very few know what it is like to be a sexual or gender minority while being raised in a religion as conservative and set in its ways as the Catholic Church. We know that queer people do not stop existing just because one is religious, but not much is known about the sense-making that goes into performing both queer and Catholic identities. Narratives are particularly important tools of both sense-making and performance for …

Class, Politics And Family Life: A Study Of Progressive Working-Class Parenting, Elise Danielle West

Theses and Dissertations

Parenting is entwined with political and social class realities, but rarely is this intersection explored. Seminal research in social reproduction theory finds that working-class parents pass on to their kids a “sense of constraint,” while middle-class parents successfully transmit class advantages that reproduce inequality (Lareau, 2011, p. 3). This research could be enriched by a political analysis that considers parents’ political ideology. On the other hand, research addressing ideological reproduction describes a model of progressive parenting that takes a stand against inequality, but it is not known how this model applies to working-class parents (Lakoff 2002). In this exploratory project, …

Community-Based Risk Communication During The Covid-19 Pandemic: A Biwoc Framework, Raven Latice Preston

Theses and Dissertations

The thesis explores the impact of COVID-19 on marginalized communities, particularly Black, Indigenous, and People of Color (BIPOC), and the disparities in risk communication that affect them. The author argues that traditional risk communication practices are often hegemonic and fail to consider the embodied experiences of marginalized communities. The thesis proposes a framework, Cooperative Risk Communication, that values Black Feminist and intersectional experiences to inform risk communication measures as an extension of institutional communication. Highlighting environmental and medical racism as factors that contribute to the vulnerability of BIPOC communities to COVID-19 and other diseases. The thesis concludes that culturally competent …