Digital Commons Network^™

Mobocertinib Antagonizes Multidrug Resistance In Abcb1- And Abcg2-Overexpressing Cancer Cells, Xingduo Dong

Theses and Dissertations

The resistance of cancer cells to multiple drugs, known as multidrug resistance (MDR), remains a significant obstacle that leads to the ineffectiveness of cancer chemotherapy. The overexpression of ATP-binding cassette (ABC) transporters, particularly ABCB1 and ABCG2, has been strongly correlated with MDR. There is an urgent need to explore and identify novel inhibitors targeting ABCB1 and ABCG2 to overcome the related MDR. Mobocertinib (TAK-788) is an orally administered, irreversible EGFR/HER2 inhibitor approved for the treatment of adult patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) harboring epidermal growth factor receptor (EGFR) exon 20 insertion mutations. This study …

Combined Cytotoxicity Of The Herbicide Glyphosate And The Fungicide Mancozeb In Mouse Neuroblastoma Cells, Heidi Ebid

Theses and Dissertations

The herbicide glyphosate and the fungicide mancozeb are globally applied on a variety of agricultural crops. Residues of both pesticides are frequently detected in food and water. Combined exposure to both compounds is therefore possible. Glyphosate and mancozeb have been separately investigated in previous studies and were shown to induce neurotoxicity. The current study investigates the cytotoxicity of different glyphosate and mancozeb combinations including mixture of mancozeb + glyphosate, combination of mancozeb followed by glyphosate and combination of glyphosate followed by mancozeb and compares neurotoxicity seen with the combinations to that of glyphosate or mancozeb using mouse neuroblastoma Neuro-2a cells. …

Exploring The Influence Of Culturally Relevant Texts On Black Male College Students’ Literacy Practices: A Case Study, Beverly A. Fields

Theses and Dissertations

African American males often experience literacy challenges in the American school system. Texts related to their lives are rarely available in the curriculum, and some educators need the skillset or strategies to engage these learners with texts related to their lives. Many studies have documented that exposure to culturally relevant texts may enhance African American males’ literacy practices. This qualitative case study explored the following research question: How do culturally relevant texts influence college-age African American males’ literacy practices? Data were collected from the instructor and student interviews, field notes, and document analysis. Seven African American college-age students were recruited …

English Language Learners: A Quantitative Study Of Digital Home Access And Its Relationship To Reading Achievement In Grades Four And Eight, Schalea S. Sanders

Theses and Dissertations

Today’s world is highly digitized and requires digital access and literacy for educational, professional, and personal success. Students from traditionally disadvantaged backgrounds, such as English Language Learners and those from households experiencing low-income, often face additional challenges accessing digital devices and high-speed Internet at home. Researchers have yet to fully examine how digital access relates to reading achievement among students in the U.S. K-12 public school system. The current study used correlational secondary data analysis to examine relationships among home access to digital devices and high-speed Internet and student reading achievement outcomes. In addition, the association between digital home access …

First Grade Teachers’ Self-Efficacy During Transformational Changes In Literacy Instruction, Amy M. Arnold

Theses and Dissertations

Schools across the county are transitioning from balanced literacy to researched based reading instruction. This shift impacts not only instructional practices in reading, but the fundamental understanding of reading development. Teachers are on the frontline of this huge endeavor. This research examined five first grade teachers’ self-efficacy through this transformational change. One-on-one interviews were conducted to explore teachers’ perspectives as they make this shift. Through interpretative phenomenological analysis, (IPA) four themes emerged; lack of training, feelings of disconnect, teacher overwhelm, and passion for change. Recommendations for practice include clear and concise communications of the shifts that are necessary when moving …

Prospective Nursing Students’ Perceptions Of The Importance Of Nutrition Literacy: A Transcendental Phenomenological Study, John J. Spano

Theses and Dissertations

Proper nutrition is essential to the prevention of chronic diseases such as cancer, heart disease, and diabetes. It is also important during the recovery period from disease as well as in the maintenance of general good health. In many health care settings, nurses are the initial health care provider with whom patients have contact. All forms of literacy require a solid foundation in fundamental literacy concepts that must be reinforced to fully develop content-specific literacy, such as nutrition literacy. Nutrition literacy is defined as the extent to which nutrition information is acquired, processed, comprehended, and applied in ways that benefit …

Examing Students’ Perceptions And Attitudes Toward The Educational Systems’ Ability To Improve Their Future: A Phenomenological Approach, Fallon Rubin

Theses and Dissertations

The purpose of this research study was to examine the perceptions and attitudes of students towards education’s ability to improve their future outcomes. This qualitative study employed a phenomenological research design in order to closely examine students’ experiences. Participants for this study were selected from a single district on Long Island from one grade. Student participants were all from similar socioeconomic backgrounds and were all eligible for free and reduced lunch through the school district. Data was collected via various methods. Interviews were conducted with each participant and each interview was recorded and later transcribed to enable for each disaggregation …

A Meta-Analysis Of Grief-Focused Interventions For Bereaved Children And Adolescents: Examining The State Of The Literature And Moderators Of Treatment Effect, Emily C. Hockenberry

Theses and Dissertations

In the wake of the COVID-19 pandemic, children and adolescents face a greater need than ever for effective mental healthcare to address distressing and disabling emotional and behavioral reactions that can occur following the death of a significant person in their lives. However, current evaluations of grief-focused interventions for bereaved youth are limited by a lack of consensus regarding how to define and measure grief symptoms in children and adolescents, a lack of clarity regarding grief-specific effects compared with effects on other forms of psychopathology, and limited power to detect moderators of intervention effect. The present meta-analysis evaluated the pooled …

Clinicians’ Attitudes Towards Using Cognitive Restructuring With Individuals At The End-Of-Life, Daniel H. Lydon

Theses and Dissertations

This cross-sectional study involving 156 clinicians explores the influence of personal factors on psychotherapy interventions and clinicians’ decisions to engage with individuals at the end-of-life (EOL) in psychotherapy. Extending qualitative research on perceived barriers to applying CBT in cancer care, this quantitative investigation delves into death anxiety, attitudes toward Cognitive Behavioral Therapy (CBT), and clinician distress tolerance in predicting the use, comfort, and confidence in applying cognitive restructuring (CR) with individuals at the EOL. Clinicians read a vignette of a terminally ill patient who is presenting as distressed and reporting several different irrational beliefs. Clinicians were then asked about their …

Does Dbt-Informed Treatment Address Comorbid Symptoms Of Social Anxiety For Adolescent Eating Disorder Patients In A Day Program? Exploring Emotion Regulation As A Mechanism For Change, Megan Bisanzo

Theses and Dissertations

Eating disorders, such as Anorexia Nervosa (AN) and Bulimia Nervosa (BN), often begin in adolescence and can be extremely challenging to treat effectively (Dawson, 2018; Martin & Golden 2014; Robatto et al., 2024). Eating disorder behaviors such as acute caloric restriction, excessive exercise, binging and purging can cause dangerous medical complications, while comorbid psychological conditions can lead to suicidal ideation and self-harm behaviors (American Psychiatric Association, 2022; Dancyger & Fornari, 2005; Martin & Golden, 2014). Social anxiety is one such comorbid disorder that can be a barrier to patients fully engaging in treatment (Goodwin & Fitzgibbon, 2002; Smith, 2018). Deficits …

Community Violence Exposure And Externalizing, Destiny Avila

Theses and Dissertations

The present study tested whether total lifetime exposure to violence and exposure as a witness and victim were associated with externalizing behavior concurrently and one-year later in a sample of pubertal-aged youth. Participants included 125 youth (n = 68 girls) who were recruited from small cities and rural communities (Susman et al. 2007). Girls were ages 8, 10, or 12 years old (M = 10.09 years, SD = 1.64) and boys were ages 9, 11, or 13 years old (M = 10.94 years, SD = 1.61). Youth were predominantly Caucasian or White and non-Hispanic (89.5%), but the sample also included …

Irrational Beliefs As A Mechanism Of Change In Rational Emotive Behavior Therapy, Miriam Motechin

Theses and Dissertations

This study investigated the mechanisms of change in Rational Emotive Behavior Therapy (REBT), a treatment developed by Albert Ellis that posits irrational beliefs contribute to emotional and behavioral distress. Prior research has shown REBT’s effectiveness, but the specific mechanisms remain underexplored. This research uses meta-analytic data to examine changes in irrational beliefs and their relationship to changes in emotions, behaviors and automatic thoughts. A moderately strong relationship was found in therapeutic intervention groups between changes in irrational beliefs and changes in emotions/behaviors. A similar relationship was found when looking at the long-term impact of changing irrational beliefs on emotional and …

Acculturative Stress, Depression, & Anxiety Among Arab Americans, Sally Kafelghazal M.S.

Theses and Dissertations

Arab Americans, those who themselves or their ancestors have immigrated fromthe Middle East or North Africa to the United States, experience a lot of stress as a result of balancing varying cultures, known as acculturative stress. Due to the underrepresentation and misrepresentation of Arabs in Americans, as well as the taboo that exists in the Arab culture regarding poor mental health and seeking mental health services, the mental health impacts of acculturation stress among this population are scarcely studied. This dissertation aims to further understand ways in which acculturative stress impacts early generational Arab American adults, including immigrants and refugees, …

Modeling The Burden Of Racial Discrimination And Its Effects On Anger Coping: A Latent Profile Analysis, Brandon Dial

Theses and Dissertations

Purpose: Perceived racial discrimination (PRD) is defined as unfair treatment received because of one’s race. Although prior research has established that PRD is a chronic psycho-social stressor with various subdimensions, there is less research exploring whether unique profiles or clusters of discriminatory experiences exist. Further, although research has identified positive relations between discrimination and anger suppression and expression, it is not known if profiles of discriminatory experiences are differentially linked to patterns of anger expression (i.e., anger suppression, outward anger expression, or anger control). Therefore, the aim of this study is to identify profiles of discriminatory experiences in a sample …

Synthesis Of Leishmania Spp Antigens For The Development Of Vaccine Candidates, Dipesh Budhathoki

Theses and Dissertations

Leishmaniasis is a neglected tropical disease caused by the protozoan parasite of the genus Leishmania. Presently no vaccine against Leishmaniasis is available, so there is a need for new anti-leishmanial treatments, including an effective preventive vaccine. We focus on developing vaccine candidates based on leishmania’s cell surface carbohydrate antigens. Saccharides heavily envelop the cell surface of Leishmania, lipophosphoglycan (LPG) becoming a significant glycan in most leishmania species. Its intrinsic antigenicity makes this polysaccharide a useful target for developing conjugated vaccine candidates against all leishmaniasis variants. In this report, we present our progress towards the synthesis of the fragments of LPG …

Black Males’ Experiences Of Resilience: A Narrative Study On College Students Experiences During The Covid-19 Pandemic, Keshia R. Graham

Theses and Dissertations

Black men’s resilience has historically been discussed, interwoven, and disguised by deficit-based models rather than strength-based ones. The current study examined Black men's resilience using a strength-based model for Black male students in higher education institutions. Specifically, the experiences and resilience of Black men before and during the COVID-19 pandemic were explored. This study targeted Black male students from an urban institution, with the aim to find out what key elements supported their resilient behavior throughout the most challenging times in their college career. The African American Male Theory and Resiliency Theory used as the theoretical framework. A narrative methodology …

Variability In Perceptions Of Complementary Health Approaches Among Graduate Student Trainees, Delaney C. Bilodeau

Theses and Dissertations

Complementary Health Approaches (CHAs) encompass a diverse range of practices which are often used both independently and alongside conventional medical treatments. Understanding how graduate students training in different fields perceive CHAs is important because these professional trainees will go on to occupy roles as healthcare practitioners, researchers, policy makers, and consumers. This study used sequential rank agreement methods (Ekstrøm, Gerds, & Jensen, 2019) to investigate variations in perceptions of CHAs in a sample of graduate students (N = 416) from 140 possible training programs. Ratings of CHA familiarity, perceptions of CHA legitimacy, and willingness to recommend CHAs were compared …

Humans Are Dust, Chelsea Nanfelt Rowe

Theses and Dissertations

I probe how objects act as intermediaries between people. These explorations reflect on the delicate navigation that happens when we intertwine our lives with others. My curiosities lie in the fuzzy aura of human life that encircles materials. Do our materials possess life or do we imbue and inject the materials in our world with personalities reflective of ourselves? My motivation for this project is to highlight the stories infused in and witnessed by things we surround ourselves with and use daily.

Exploring Factors Influencing The Adoption Of Ai Tools In Auditing: A Mixed-Methods Study, Fahad Alsudairi

Theses and Dissertations

Artificial Intelligence's (AI) rise has created value for organizations and society, prompting scholars to study its spread across many areas. However, the impact of AI adoption on governmental organizations still needs to be explored. Governmental entities face unique challenges distinct from private organizations, and existing research often focuses on the perspectives of AI experts or senior management, neglecting the insights of lower-level employees who will use the system daily.

This study investigates the multifaceted factors influencing the intention to adopt AI tools within a governmental auditing bureau in Saudi Arabia. To the best of our knowledge, no previous study has …

Investigation Of Brain Function And Structural Development As Risk Factors Of Suicidal Thoughts And Behaviors, Yi Zhou

Theses and Dissertations

Background: Identifying risk factors for suicidal thoughts and behaviors, especially causal ones, will be imperative to improving screening and treatment interventions. To identify replicable brain-based risk factors, there is increasing evidence indicating the need for large sample sizes, in the hundreds to thousands, in order to achieve a sufficient level of statistical power to detect them. Furthermore, longitudinal studies of brain and behavioral factors will be essential to understanding how suicide develops, especially the transition from suicide ideation to attempt. While experimental studies may not be feasible or ethical, genetically informed methods for testing evidence for causation are an alternative …

Transitions In Patterns Of Substance Use During Early Adolescence: Bidirectional Associations With Externalizing Behaviors, Courtney B. Dunn

Theses and Dissertations

Early adolescents who engage in polysubstance use, defined as the use of three or more different substances, are at particularly high risk of future substance use disorders and adverse psychosocial outcomes. However, little is known about the development of substance use patterns during early adolescence, particularly among youth living in urban settings. Although theory and research suggest that youth with greater externalizing behaviors (e.g., aggression, delinquent behavior) may be more likely to escalate to polysubstance use at an early age, few studies have examined bidirectional relations between externalizing symptoms and polysubstance use. The goal of this study was to (a) …

Prosthetic Attention In Upper Limb Loss: User Experiences, Clinical Perceptions, And Developing Candidate Items, Tanu Bhargava

Theses and Dissertations

The human hand is a powerful tool essential for performing a range of tasks from simple to complex, and it plays a crucial role in social interactions and environmental engagement. Upper limb (UL) loss disrupts these functions and significantly impacts daily life. Prosthetic devices can partially restore these abilities and improve quality of life, but they lack the intuitive control and sensory feedback of natural hands. Consequently, operating a UL prosthesis requires substantial attentional demands, a factor that potentially contributes to high rates of device dissatisfaction and disuse. For UL prosthesis users, managing attentional resources is critical to efficiently controlling …

Functional Family Therapy: A Multi-Year Statewide Program Evaluation, Natalie Finn

Theses and Dissertations

Functional Family Therapy (FFT) is a family-based treatment program for youth with externalizing behavior problems, often involved in juvenile justice and child welfare systems. FFT is an evidence-based program and has been implemented across many states, including the state of Virginia. Objective. The present study performed a program evaluation and observational study of the implementation and sustainment of FFT in Virginia, during the first five years of implementation. Method. Participants included all youth who participated in FFT in Virginia between October 2017 and June 2022. Secondary data analysis was conducted using data entered by therapists and supervisors into the FFT …

Sphingosine Kinase 2 Depletion Dysregulates Hepatic Redox Metabolism And Enhances Inflammation In Early Metabolic Dysfunction-Associated Steatohepatitis (Mash), Kaitlyn Georgene Jackson

Theses and Dissertations

Metabolic dysfunction-associated steatotic liver disease (MASLD) currently affects one in three people worldwide; its prevalence is growing alongside other cardiometabolic disorders. Aberrations to redox and sphingolipid metabolism contribute to MASLD pathologic progression. Sphingosine-1-phosphate (S1P) is an active lipid, meaning that S1P participates in biochemical processes within the cell. S1P is generated by two distinct isoenzymes, sphingosine kinase (SphK)1 and SphK2. The localization of the SphK enzyme dictates S1P function. While cytosolic SphK1-generated S1P is well-characterized, nuclear and mitochondrial SphK2-generated S1P is less known. Moreover, SphK2 depletion effects on cellular redox processes and inflammation are not well-defined.

This study defines the …

Trait Mindfulness And Political Polarization: Investigating Neural Responses And Emotional Orientations, Elif Z. Celik

Theses and Dissertations

The rapid escalation of political polarization has led to increased social distancing, aggressive partisan behavior, and discriminatory attitudes among Democrats and Republicans. Prior research has indicated that mindfulness is associated with increased compassion, reduced prejudice, and diminished aggression toward out-group members. This thesis investigates the relationship between trait mindfulness and political polarization by examining neural responses and emotional orientations in individuals with varying levels of mindfulness. This research measured brain activity using functional near-infrared spectroscopy (fNIRS) while participants viewed emotionally charged political videos and neutral content. The primary hypothesis suggested that individuals with high trait mindfulness would exhibit left-lateralized prefrontal …

The Role Of Hdac6 In Periodontal Inflammation, Hannah S. Lohner

Theses and Dissertations

Periodontal disease is a polymicrobial infection-induced chronic inflammatory disease and results in irreversible tissue damage and bone loss. While bacteria play a large role in the initiation of this disease, excessive and prolonged inflammatory immune responses are fundamental for its progression, making host directed therapy (HDT) a possible and potentially valuable treatment. Histone Deacetylase 6 (HDAC6) is an enzyme that removes acetyl groups from both histone and non-histone proteins, giving it a potential role in regulating inflammation initiated by pathogenic oral bacteria. Previous studies indicated that HDACs act as a bivalent regulator in inflammatory responses; however, the role that HDAC6 …

“You Are Not Obligated To Complete The Work, But Neither Are You Free To Desist From It.” Richmond Jews In Social Activism Post Civil Rights, Tracy S. Herman

Theses and Dissertations

For centuries, the Jewish people have faced expulsions, pogroms, massacres, and Propaganda. that runs so deep it would be like staring into an abyss. This oppression has motivated Jewish activists worldwide to fight back not only on behalf of the Jewish community but for many areas of perceived need. Jewish involvement in social activism in the U.S. has been particularly recognized by scholars of the labor and Civil Rights movements. This thesis is based on eighteen oral history interviews focused on social activism in Richmond, Virginia since the Civil Rights era. The author conducted these interviews in 2021, 2023, and …

Plk1 Overexpression Drives Tumorigenesis In A Prostate Cancer Mouse Model, Emile Kachouh

Theses and Dissertations

Prostate cancer is the leading cause of cancer-related deaths among men worldwide, and the development of resistance to existing treatments necessitates the exploration of new therapeutic strategies, including combination therapies. This study investigates the role of Polo-like kinase 1 (PLK1), located on chromosome 16p12.2, as an oncogene in prostate cancer. We generated a transgenic mouse model with prostate-specific overexpression of PLK1 to closely mimic human prostate cancer progression. Quantitative PCR (qPCR) analysis was employed to characterize the molecular profile of PLK1, revealing its implication in multiple pathways. To further elucidate the functional consequences of PLK1 overexpression, we confirmed phenotypic progression …

The Effect Of Local Anesthesia When Used In Dental Restorative Cases Under General Anesthesia On Control Of Postoperative Comfort, Elizabeth S. Kleefisch Dds

Theses and Dissertations

Purpose:

To determine the effect of local anesthesia on postoperative comfort in patients undergoing dental care under general anesthesia.

Methods:

This study was modeled as a double-blinded randomized control trial. Patients included healthy children under the age of 6 years scheduled for restorative dental treatment under general anesthesia (GA). Patient behavior was evaluated preoperatively and postoperatively using the Faces, Legs, Activity, Cry and Consolability (FLACC) or other pain score and postoperatively using the Parent’s Postoperative Pain Measure (PPPM). Intraoperatively, participants followed a standardized general anesthesia protocol and were given either local anesthetic (LA) infiltration using 2% Lidocaine 1:100,000 Epinephrine by …

Developing And Testing A Model Of Discrimination, Internalized Oppression, Mental Health, And Suicidality In Disabled Transgender And Gender Non-Binary (Tgnb) Individuals, Stephanie L. Cull

Theses and Dissertations

Transgender and gender nonbinary (TGNB) individuals experience high rates of discrimination and microaggressions that can lead to internalized cisgenderism and adverse mental health outcomes such as depression, anxiety, and suicidality. Individuals with disabilities similarly experience high rates of discrimination and microaggressions that can lead to internalized ableism and increased adverse mental health outcomes. Although both of these populations have been researched separately, very little extant research has explored the intersections of disabled and TGNB identities. The purpose of this study was to explore a hypothesized pathway leading from microaggressions through internalized oppression and mental health to suicidal ideation within a …