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Development Of Novel Plasminogen Activators From Fragments Of Streptokinase Enzyme, Vijay G Mr

Theses and Dissertations

Thrombotic disorders such as myocardial infarction, ischemic stroke, pulmonary embolism and deep vein thrombosis remain major causes of mortality and disability worldwide, creating a continuing need for effective, safe and affordable thrombolytic therapy. Streptokinase is one of the most widely used plasminogen activators because of its activity, low cost and broad availability. However, its wider clinical utility is limited by high immunogenicity, allergic reactions, neutralizing antibody formation and poor suitability for repeat administration. This thesis aimed to develop novel streptokinase-derived plasminogen activators by identifying smaller functional fragments that retain thrombolytic activity while potentially reducing immunogenicity.

A literature-guided fragment-based strategy was …

Examining The Relationship Between Past Involvement In Sexual Violence, Gender, And Rape Myth Acceptance In College Student-Athletes, Sarah Baker

Theses and Dissertations

Sexual violence (SV) is a persistent concern on U.S. college campuses, with student-athletes at higher risk for both perpetration and victimization. Rape myth acceptance (RMA) reflects beliefs that excuse or downplay SV, but it is unclear how these beliefs relate to student-athletes’ personal experiences with SV. This study examined RMA based on past SV involvement and gender, with attention to individuals reporting both perpetration and victimization. Participants were 350 NCAA Division III student-athletes who completed measures of SV perpetration and victimization, RMA, and sexism. Analyses evaluated differences in RMA by past involvement in sexual violence and gender while controlling for …

Optical Integrated Sensing And Communication: Deep Reinforcement Learning-Based Beam Tracking For Dynamic Vehicle-To-Everything Networks, Akshat Sharan

Theses and Dissertations

Optical Wireless Communication (OWC) promises ultra-high bandwidth for vehicular networks but suffers from critical beam misalignment in dynamic environments. The emerging paradigm of Optical Integrated Sensing and Communication (O-ISAC) addresses this challenge by unifying the sensing and communication functions over a single shared optical aperture, enabling real-time environmental awareness to guide beam steering. However, the multi-objective, stochastic nature of this joint optimization problem renders classical closed-form controllers inadequate. This thesis proposes and evaluates a deep reinforcement learning framework for continuous beam tracking in a 2D vehicular O-ISAC scenario. We conduct a comprehensive comparative study of four state-of-the-art deep RL algorithms: …

Investigations Into Biophysical Mechanisms Of Amphiphilic Molecules At Protein And Membrane Interfaces, Samuel Richard Pennock

Theses and Dissertations

Amphiphilic compounds play a key role in chemical biology due to their ability to associate with biochemical complexes through a diverse set of noncovalent interactions. Interactions between amphiphiles and biological targets elicit a wide array of modulatory effects, structural stability, and activity. However, due to the inherent complexity of these interactions, there has yet to be a broadly predictive framework for determining whether a given amphiphile-target interaction will be beneficial or deleterious. This thesis seeks to advance the mechanistic understanding of amphiphile-target interactions by investigating two distinct but unified systems. In the first study, the effects of fatty acid ionic …

From Compliance To Inclusion Through Collaborative Action Research (Car): Service-Animal Access In Experiential Settings In Higher Education, Allison Christina Gainer

Theses and Dissertations

Experiential learning is essential for degree completion, licensure, and professional preparation, although access to service animals in practical contexts is often ambiguous and inconsistently implemented. This study examined the disconnect between legal access protections and institutional practices in real-time access decisions driven by safety, program integrity, accrediting standards, and decentralized decision-making. The purpose of this qualitative Collaborative Action Research (CAR) study was to examine Rowan University’s understanding, interpretation, and implementation of service animal regulations and procedures and to suggest alternatives for legal and equitable access. The study was based on the social model of disability and used four CAR cycles. …

Identifying Failure Behaviors In Stereolithography From Varied Print Orientations, Kevin Veltre

Theses and Dissertations

Stereolithography (SLA) is an additive manufacturing (AM) technique that utilizes photopolymerization to create three-dimensional shapes by strategically printing layers of material. Printing parameters such as layer orientation, print resolution and post cure can affect a specimen’s homogeneity, longevity and mechanical characteristics. Because of this variability, print parameters must be carefully considered when designing products and print processes for desired components, as manufacturers often fail to include all relevant print settings when advertising mechanical properties. For this study, 130 SLA-printed specimens were created with 100-micron print layer thickness and print orientations varying between 0 and 90, including intermediate orientations, to observe …

Transcriptomic And Genomic Insights Into Nutrient Stress Responses And Subgenome Evolution In Chenopodium, Ashley Kathleen Marcheschi

Theses and Dissertations

Chenopodium is a diverse genus of nutritionally and ecologically important species in the Amaranthaceae family. This thesis investigates two outstanding questions in the genus: how Chenopodium quinoa responds transcriptionally to nutrient deficiency and how Australian Chenopodium species are related through their subgenomic ancestry and evolutionary history. First, we characterized transcriptomic responses of C. quinoa to deficiencies of twelve essential macro- and micronutrients across leaf and root tissues using RNA sequencing. Leaves showed the strongest responses under nitrogen, potassium, magnesium, and zinc deficiency, while roots responded more evenly across conditions. Recurring responses included suppression of photosynthesis, remodeling of translational machinery, reactive …

A Chorus Of Voices: Student And Teacher Shared Dialogical Experiences And Insights, Jennifer Anne Reynolds

Theses and Dissertations

Dialogue is inherently tied to learning, but as a secondary English Language Arts (ELA) classroom teacher it can be difficult to facilitate classroom dialogue that provides authentic learning opportunities for every student. I wanted to learn more about the student experience, so I implemented an action research study to increase my understanding of how students learn through dialogue. My research question was: How does collaborative languaging, to facilitate student-teacher interaction, lead to improved classroom mediation, authentic learning, dialogue, and development? I conducted transformative action research in my classroom, focusing on students enrolled in my general English 10 classes. In an …

The Effects Of Social Impact Mentoring On Women Seeking Employment, Adriano Santos Carneiro

Theses and Dissertations

Women seeking employment often face barriers such as limited professional networks, reduced access to career guidance, and lack of consistent support during the job-search process. This study examined the effects of a social impact mentoring program that connected women seeking employment with women professionals who served as mentors. Participants included 11 mentees who were seeking employment opportunities and 11 mentors who were employed or recently employed in professional roles. Using a mixed-methods pre-post design, the study collected quantitative survey data and open-ended responses before and after four virtual mentoring sessions. Mentee measures focused on confidence in securing employment and readiness …

Beyond Static Measures: The Predictive Validity And Classification Accuracy Of A Dynamic Assessment Of Decoding For Early Elementary, Bridgett Bakula

Theses and Dissertations

Early and accurate identification of children at risk for reading difficulty is essential to prevent long-term academic failure, yet traditional static assessments often struggle to distinguish between a true reading disorder and a lack of prior instruction. This is particularly evident in the early grades, where floor effects and cultural/linguistic biases limit the classification accuracy of traditional screeners. This study investigated the predictive validity and structural utility of the modifiability index of a dynamic assessment (DA) of decoding, administered in kindergarten. Unlike static measures that evaluate "already actualized" knowledge, DA measures a student's learning potential and modifiability, or the capacity …

Policy Analysis Of The Inclusion Of Mitigation Measures In The Re-Design And Construction Of The New Frances Scott Key Bridge, Patrick John O'Connor

Theses and Dissertations

This thesis discusses the tragic event of the container ship MV Dali impacting the Francis Scott Key Bridge on March 26, 2024, leading to the collapse of the structure and killing six people despite having collision mitigation protections in place. This research examines how late twentieth-century structures are inadequate for current shipping demands and emphasizes that updated mitigation design criteria must accommodate larger modern vessels as governments replace or upgrade these structures. This paper will examine four case studies of different collisions that have similar circumstances to the Francis Scott Key Bridge collapse and review National Transportation Safety Board reports …

How Young Mothers’ Interpersonal And Emotional Well-Being Impacts Parental Stress And Dating Violence, Jonathan Jin

Theses and Dissertations

This two-part dissertation investigated two distinct, yet interconnected aspects of young mothers’ wellbeing which span individual and interpersonal factors. Study 1 examined how adverse childhood experiences (ACEs) are related to parental stress, and how symptoms of anxiety and depression might mediate this association. Within a sample 255 young mothers with an average age of 22.2 (SD = 2.3), the pooled results of a parallel mediation model across 10 imputed datasets indicated a significant average direct effect of ACEs on parental stress (0.25, p < .01), suggesting that experiencing a history of ACEs was significantly associated with more parental stress. Study 2 examined the relationship between young mothers’ romantic attachment, emotion regulation, and dating violence (DV) victimization. In a different sample of 256 young mothers with an average age of 19.8 years (SD = 1.1), more avoidant (less secure) romantic attachment styles (β = 0.26, SE = 0.1, p < 0.01) and more anxious romantic attachment styles (linear component β = 3.81, SE = 0.9, p < 0.001 and quadratic component β = -2.86, SE = 0.9, p < 0.01) were significantly associated with greater DV victimization. Future research may extend this work by using longitudinal designs to test bidirectional links between interpersonal and emotional wellbeing factors among young mothers.

¿Cómo Se Hace Translanguaging En Kindergarten?, Diana Marie Franco

Theses and Dissertations

This qualitative case study explored the use of translanguaging among kindergarteners and examined how students’ use of their full linguistic repertoire served as a pedagogical practice in a two-way dual-language, Spanish-world classroom. The findings indicated that translanguaging functioned as an academic and linguistic resource, supporting student engagement and participation in classroom learning. Students used their complete linguistic repertoires to clarify meaning, negotiate understanding, develop vocabulary, make cross-linguistic connections through cognates, and demonstrate emerging metalinguistic awareness. These findings contribute to the growing body of research supporting translanguaging as a pedagogical approach in dual language classrooms, especially in early childhood education. The …

Do I Belong Here?: A Narrative Inquiry Into Ableism, Accommodation, And Professional Identity Among Medical Students With Mobiilty Disabilities, Nicole J. Albano Robinson

Theses and Dissertations

Abstract Nicole J. Robinson DO I BELONG HERE?: A NARRATIVE INQUIRY INTO ABLEISM, ACCOMMODATION, AND PROFESSIONAL IDENTITY AMONG MEDICAL STUDENTS WITH MOBILITY DISABILITIES 2025-2026 Ane Turner Johnson, Ph.D. Doctor of Education in Educational Leadership Despite federal and institutional disability policy designed to protect equitable access to education, medical students with mobility disabilities encounter systemic barriers shaped by ableism, inconsistent accommodation practices, cultural bias, and exclusionary learning environments. This qualitative study sought to describe the lived experiences of undergraduate medical students with mobility disabilities within U.S. MD and DO programs. A qualitative narrative inquiry using Kim’s (2016) two-phase life story interview …

Hybrid Lipid-Gold Nanoparticles Designed For Simultaneous Gene Therapy And Photothermal Therapy Against Cancer, Navya Sree Devaguptapu

Theses and Dissertations

Traditional cancer treatments such as chemotherapy and surgery include adverse side effects and acquire resistance. Here, I developed a novel hybrid lipid-gold nanoparticle technology (LGNP) to achieve simultaneous gene regulation and photothermal therapy, specifically targeting pediatric acute myeloid leukemia (AML) and ovarian cancer. This core material consists of slice core/gold nanoshells, which are efficient heat transducers where NIR light activates nanoshells embedded in tumors, generating localized heat for tumor ablation. The ionizable lipid coating facilitates intracellular delivery of nucleic acids, such as mRNA or siRNA, to modulate gene expression effectively. Lipid-gold hybrid nanoparticles (LGNPs) are synthesized via a controlled self-assembly …

Analytic Solutions To Oceanographic Kinematic Property Equations, James Turbett

Theses and Dissertations

With the recent advent of large submesoscale drifter deployments, interpreting the timeseries of kinematic properties (KP) - divergence, vorticity, shear, and normal strain rates observed therein is a pressing issue. The evolution equations for the four KP are derived from the two-dimensional momentum conservation equations. The resulting equations, a nonlinear coupled system of ordinary differential equations, capture the submesoscale motion of drifters along fixed ocean surfaces, with time and space scales on the order of days and kilometers. This thesis builds theory around KP timeseries behavior by solving for the analytic solutions in the particular cases that one KP is …

Vibro-Seismic Approach For Remediation Of Near-Wellbore Damage, Mounira Ahmed Abdallah

Theses and Dissertations

The research highlights the importance of vibro-seismic technology in the oil and gas industry. The primary objective of this study is to demonstrate how the vibro-seismic method enhances formation properties which are porosity, and permeability. Ultimately, this will lead to improved productivity and its application to remove the wellbore damage.

The research discusses whether or not the formation properties will be enhanced by the optimized acoustic vibration formation parameters. The thesis details laboratory experiments on core plugs, and four key findings are presented. The experimental work first showed that the use of the proper and optimum parameters enhanced the porosity …

The Effects Of Functional Coaching On Increasing Functional Play Behaviors In Adults, Abby L. Pattengale

Theses and Dissertations

Play is a critical developmental context for children with autism spectrum disorder (ASD), supporting cognitive, social, communication, and adaptive skill development. However, many adults, specifically registered behavior technicians (RBTs), demonstrate limited engagement in developmentally appropriate play behaviors, which can restrict the quality of play-based interventions, which are essential for effective treatment. However, little research has examined interventions designed to improve adult play behaviors. The purpose of this study was to evaluate the effects of functional coaching on increasing adult functional play behaviors during therapy sessions with children diagnosed with ASD. Two RBTs participated in the study, and two children receiving …

On The True Interstellar Anisotropy Of Tev Cosmic Rays And Its Implications For The Local Interstellar Medium, Noufel D. Maalal

Theses and Dissertations

Several ground-based cosmic ray (CR) air shower experiments have produced sky maps of intensity anisotropy in the energy range from 1 TeV to a few hundred TeVs with very high statistics and angular resolution. These measurements provide opportunities to study CR sources and propagation in the interstellar medium (ISM). Such studies present two major difficulties. Firstly, CRs are deflected by the heliospheric magnetic field on the last stretch of their journey to Earth. Secondly, measurements at different latitudes are difficult to compare, leading to uncertainties in latitudinal variations on the order of the observed anisotropy. Experiments usually assume latitudinal variations …

Fraud And Focus: Examining Self-Control Strategies In Students Experiencing Impostor Phenomenon, Francesca Angela Catalano

Theses and Dissertations

Impostor phenomenon (IP) is a common experience among individuals in achievement contexts characterized largely by feelings of self-doubt, attributions of success that focus on external factors, and beliefs that one is “fooling” others about their competence. Current research suggests the effects of IP are complex (e.g., IP is associated with higher grade point average and productivity but also self-handicapping, psychological distress, and difficulties adjusting to college). To better understand these complex effects, this study proposes a self-control perspective for IP, where this phenomenon is seen as involving additional self-control burdens. Specifically, the study examines whether IP is associated with grade …

Grit, Self-Assessment, And Second Language Proficiency: A Large-Scale Examination Using Data From The Language Ability Self-Evaluation Resource, Andrew T. Skoy

Theses and Dissertations

Grit has been defined as being "perseverance and passion for long-term goals" (Duckworth et al., 2007). Research has tied grit to success in the discipline of second language acquisition (SLA), where researchers have adapted Duckworth's general grit self-assessment instrument to capture measurements of grit within second language learners (Teimouri et al., 2022). Such a scale appears on the Language Ability Self-Evaluation Resource (LASER), a standardized language proficiency test developed by researcher at Brigham Young University. With the aim of replicating the studies that were done to validate the design of the LASER, responses to the grit-measuring section of the test …

A Holistic Framework For Enhancing Machine Learning Reliability: From Model Architecture And Algorithm Design To Human Interpretability, Kyle Naddeo

Theses and Dissertations

Modern machine learning systems can perform well on benchmarks yet fail in ways that are difficult for users to anticipate, interpret, or manage. This dissertation treats reliability as more than accuracy: a reliable system performs when it can, signals when it should not be trusted, and supports abstention, fallback, escalation, or human review. Unlike robustness, which emphasizes performance under shift, corruption, adversarial perturbation, or drift, reliability also requires recognizing limited competence, preserving useful semantic structure when fine-grained certainty is unjustified, and exposing mechanisms that make failures understandable. The dissertation develops this view through four contributions. Uncertainty-aware decision heads provide portable …

Learning Trajectories Of Online Batch Selection Methods, Luke Green

Theses and Dissertations

Modern deep neural networks achieve strong performance on large-scale datasets, but often require substantial training time. Online batch selection methods seek to reduce this cost by updating models on informative subsets of each batch rather than on all available examples. Recently introduced methods leverage teacher models and report substantial speedups, particularly in noisy-label settings. However, comparisons are often based on the number of epochs required to reach a target test accuracy, a coarse metric that is sensitive to implementation details and may obscure important differences in learning dynamics. In this thesis, we implement several online batch selection methods in a …

Beyond Single Images: A Comprehensive Benchmark For Album-Level Vision-Language Understanding, Shawn Huang

Theses and Dissertations

Automatic album organization has been studied extensively over the past decades due to significant progress in digital photography. Recent Vision-Language Models (VLMs) have shown strong performance on multi-image understanding, making them natural candidates for automating album organization workflows. While VLMs’ abilities in multi-image understanding have been widely studied, their performance on album organization remains underexplored. To bridge this gap, we introduce AlbumBench, the first comprehensive benchmark for automatic album organization. Specifically, we (1) define album organization tasks as photo selection for album-specific user objectives, photo rating according to how well user intents are fulfilled, and album-specific photo grouping given a …

Enhancing Emotional Support For Advanced Placement Students, Laine Mckay Nesbitt

Theses and Dissertations

Although they may struggle with their emotional well-being, academically accelerated students are underrepresented in the research literature. Teachers are in a position to influence students' emotional well-being. Minimal qualitative research with student voices has been conducted. This study highlights the perspectives of students who have participated in an academically accelerated program. Students were interviewed about what their teachers do to help or hinder their emotional well-being and what they wish that teachers could do to support their emotional well-being. A total of 14 high school students were interviewed using the critical incident technique (CIT). The participants emphasized the importance of …

Respect And Aggression In Intimate Relationships: A Grounded Theory Of Relational Responsiveness, Aaron T. Fife

Theses and Dissertations

The negative effects of aggression in intimate relationships have been well documented through research and clinical literature (Lawrence & Bradbury, 2001; Shortt et al., 2006). Conversely, the positive effects of respectful behavior are well-known (Gottman, 1994; Dew & Wilcox, 2013). This important dimension of relationships is crucial to understanding what makes up healthy and unhealthy relationships. However, little is known about how couples understand the varying types of respect and aggression within intimate relationships, nor how they are lived and experienced relationally. The purpose of this study is to explore the dyadic processes behind respect and aggression as well as …

Toward Passwordless Document Encryption, Isaac Henry Teuscher

Theses and Dissertations

Document files with sensitive information are used across nearly every industry. In recent years, cyberattacks targeting cloud-based file transfer applications have resulted in millions of sensitive documents being exposed. Although document encryption methods exist, they are often limited in usability, security, or deployability. Password-based encryption, the most widely available option, remains vulnerable to brute-force attacks, unauthorized sharing, and human error. We address these gaps in three phases. First, we present a structured comparative framework adapted from the usability-deployability-security model to evaluate nine document encryption methods across 15 design properties, identifying the benefits and limitations of current approaches. Second, we design …

A Lesson In Class: How Parents' Class Identity Changes Relate To Children's Exposure To Social Classes -- A Latent Profile Analysis, L. Caroline Moore

Theses and Dissertations

Class inequality in the United States has reached levels not seen since the late 1920s. This inequality has been linked to numerous harmful societal outcomes and may be particularly detrimental for children, who often experience limited intergroup contact with individuals from different social class backgrounds. Drawing on Social Identity Theory and the significant role parents play in shaping children's social environments, this study examined how White and Black parents' changes in perceived social class from childhood to adulthood relate to the ways they prioritize exposing their children to different social class environments (N = 702, U.S. sample). Latent Profile Analysis …

This One's For The Girls: Co-Creating A Social Confidence Group Intervention For Autistic Adolescent Girls, Kendra Noelle Zitzman

Theses and Dissertations

Numerous studies have been completed regarding social confidence-building interventions for individuals with autism. However few studies have studied autistic females' experience with social confidence and targeted interventions for their unique needs. The purpose of this study was to co-create a social confidence curriculum with adolescent and young adult autistic females based on their experiences, perceived strengths and weaknesses, and goals. We analyzed first-person experiences and perceptions about social confidence-building interventions and supports. We used pre- and post-group interviews of the adolescent autistic participants (n =11) and college-aged mentors (n = 4), pre- and post-group measures with the Social Responsiveness Scale, …

Influence Of Timed Repeated Readings On Grade 2 French Immersion Students' Reading Fluency And Comprehension, Kathryn Rosie Baldwin

Theses and Dissertations

This study examined the effects of Timed Repeated Reading (TRR) on reading fluency, comprehension, and reading attitudes among second grade students in a French Dual Language Immersion (DLI) program in Utah. Forty-one students from two pre-existing classroom groups participated over 11 weeks, with one class receiving TRR and the other serving as a control. Fluency was measured in correct words per minute (CWPM), comprehension through cloze tests, and attitudes using a seven-item affective survey with a four-point visual scale. A mixed between-within subjects ANOVA analysed pre- and post-test data across four intervals. Results showed significant fluency gains over time for …