Digital Commons Network^™

Role Of Microrna-155 In A Mouse Model Of Colon Cancer., Claire Mitchell Midyette

Theses and Dissertations

Colorectal cancer remains the third most common malignancy and the fourth most common cause of cancer mortality worldwide. Dysregulated miRNA levels are associated with several types of malignancies and may serve as important biomarkers and/or therapeutic targets in colorectal cancer. We examined the role of miRNA-155 on tumorigenesis and associated symptoms using a well-characterized mouse model of colorectal cancer. C57BL/6 wild-type mice and miRNA-155-/- mice (n=7-13 group) were given a single injection of AOM (10mg/Kg) followed by 3 cycles of DSS (2% in the water for 1 week followed by 2 weeks of plain water). A C57BL/6 wild-type group that …

A Case Study Seeking Indicators Of Coherence In A Pete Program, Robert John Doan

Theses and Dissertations

A Case Study Seeking Indicators of Coherence in a PETE Program

The purpose of this study was to examine the coherence of one facet of a single PETE program. Of particular interest was the role of one unique content course within the curriculum. Teacher educators have been challenged to respond to a variety of forces and to design more effective programs of teacher preparation. There are at least two challenges for teacher educators to respond to these challenges to their effectiveness. One challenge is that there is little empirical research focused on teacher educators themselves (Grundy & Hatton, 1995; John, …

Deducing Vertex Weights From Empirical Occupation Times, David Collins

Theses and Dissertations

We consider the following problem arising from the study of human problem solving: Let $G$ be a vertex-weighted digraph with marked "start" and "end" vertices. Suppose that a random walker begins at the start vertex, steps to neighbors of vertices with probability proportional to their weights, and stops upon reaching the end vertex. Could one deduce the weights from the paths that many such walkers take? We analyze an iterative numerical solution to this reconstruction problem, in particular, given the empirical mean occupation times of the walkers. We then consider the existence of a choice of weights for a given …

Investigation Of Start Domain Proteins In Human Luteinized Cells And Cos-1 Cells, Bo Shi

Theses and Dissertations

After the luteinizing hormone surge of the menstrual cycle, the ovarian follicular granulosa and theca cells terminally differentiate to form the luteal cells of the corpus luteum. During this process known as luteinization, granulosa cells begin to synthesize large quantities of progesterone, a hormone essential for pregnancy. The rate limiting step for the de novo synthesis of pregnenolone (the precursor to progesterone) is the transport of cholesterol from the outer to the inner mitochondrial membrane, a process mediated by STARD1. STARD1 contains a C-terminal lipid binding domain holding one molecule of cholesterol, and an N-terminal domain targeting STARD1 to the …

Drought Indices In Decision-Making Process Of Drought Management, Ekaterina Negodyaeva Altman

Theses and Dissertations

Drought indices are one of the most important elements of an effective drought monitoring and early warning system. They help to characterize drought and guide appropriate responses to reduce drought impacts. Drought indicators are more useful than raw data in decision-making process, even though each index has specific use and limited by its strengths and weaknesses. The literature review showed the evaluation of drought conditions by decision-makers as an important issue, but so far no research has been done to understand how decision-makers use diverse and often conflicting values of drought indices to make drought declarations. This research studies how …

An Investigation Into The Influence Of Dietary Saturated Fat And Quercetin Supplementation On Adiposity, Macrophage Behavior, Inflammation, And Non-Alcoholic Fatty-Liver Disease, Reilly Enos

Theses and Dissertations

The overall objective of this dissertation was to examine the degree to which manipulation of the saturated fat content of a high-fat diet influenced obesity-related outcomes as well as to see if the naturally-occurring flavonoid, quercetin, could attenuate the resulting obesity and related metabolic and inflammatory side effects. Specifically, these studies examined 1) the influential role of saturated fat on macrophage function, inflammation, and other obesity-related comorbidities, including non-alcoholic fatty-liver disease, and 2) the potential benefits of quercetin supplementation. Overall, results from these studies suggest that adiposity, macrophage behavior, inflammation, insulin resistance, and non-alcoholic fatty-liver disease progression can be greatly …

The Effects Of Rainfall-Runoff On Particulate Organic Carbon Cycling In Salt Marshes, Si Chen

Theses and Dissertations

Low tide rainfall-runoff processes have been proposed as a kind of coastal ocean "hot moment" capable of transporting disproportionately large amounts of material from the salt marsh surface to the water column. However, the resulting organic matter cycling has not been well characterized and the cumulative effects of recurring short-term low tide rainfall events are not known, especially in the context of outwelling. The purpose of this Ph.D. research is to quantitatively evaluate the effects of low tide rainfall on particulate organic carbon (POC) cycling in a South Carolina salt marsh.

This dissertation is comprised of four parts. First, a …

Environmental Pre-Conditioning Of Bacterial Populations And Communities To Extreme Acidity, Gabriel Joseph Swenson

Theses and Dissertations

The ability of opportunistic enteric pathogens to cause disease is effected by their ability to survive the variable and lethal acidity of the mammalian host gastrointestinal milieu. In many of these pathogens, survival is conferred by an acid stress response (ASR). ASR is elicited when bacterial cells are pre-conditioned in sub-lethal acidity (pH 4-6) which induces rapid biochemical and physiological modifications and facilitates survival when extreme acidity (pH 1-3) is encountered. In Vibrio cholerae, the causative agent of the diarrheal disease Cholera, ASR was initially investigated in an effort to determine how this ubiquitous aquatic bacterium is capable of causing …

Effect Of Matrix Modulus On Cancer Stem Cells And Tumorsphere Formation In Three-Dimensional-Engineered Matrix, Samaneh Kamali Sarvestani

Theses and Dissertations

Maintenance of cancer stem cells (CSCs) is regulated by their microenvironment. As cancer cells are affected by many factors in their microenvironment, a major challenge is to isolate the effect of a specific factor on cancer stem cells (CSCs) while keeping other factors unchanged. We have developed a synthetic inert 3D polyethylene glycol diacrylate (PEGDA) gel culture system as a unique tool to study the effect of microenvironmental factors on CSCs response. Synthetic hydrogels provide the flexibility to design three-dimensional (3D) matrices to isolate and study individual factors in the tumor microenvironment.

The objective of this work was to investigate …

Going Into The Word-Hoard: The Writing Process, Language, And Its Implications In The Poetry Of Medbh Mcguckian And Paul Muldoon, Elizabeth Peele

Theses and Dissertations

As two prominent figures of Northern Irish poetry, Medbh McGuckian and Paul Muldoon are often discussed as being "difficult" and "oblique." However, I argue that this categorization of their poetry is too simplistic and overlooks the dissimilarities in their writing process and view of language, and ultimately, in their poetry itself. By going back to the fundamentals of their works, I claim that the basis for this dissimilarity is, in fact, a differing view of the founding blocks of poetic language. McGuckian sees syntax as being the important factor while Muldoon focuses on the individual lexical meaning of words. These …

Wireless Pressure Sensor System For Medical Applications, Xuehe Wang

Theses and Dissertations

Telemedicine in the modern era is a rapidly developing industry. In a telemedicine system, sensor is the key elements and play important role in any telemedicine applications, especially implantable sensors. Unlike traditional in vitro sensors, there are some special requirements for them like battery-less, compact, and bio-friendly. Therefore, many researchers in institutes as well as in industry are continually developing implantable sensor and sensor system to fulfill the requirements of medical applications.Nine in one thousand people in the United States are born with congenital heart defects and sixty percent die before one year old. As a result, it will be …

Ulysses In The Age Of Digital Remediation, Melissa Hart Higgins

Theses and Dissertations

This thesis is an in-depth study of the implications of digital technologies and information literacy for the reading and scholarly study of James Joyce's novel Ulysses. Because the reading experience of Ulysses depends heavily on both its physicality and the interaction of the reader with the text, the changes in reading practices and scholarly study brought about by digital adaptations and hypermediations of this novel can offer new modes of understanding and characterizing readers relationships with text, as well as how the readers' digital interactions with Ulysses might engender or inhibit potential interpretations.

Each of the three chapters in this …

Into A Wild New Yonder: The United States Air Force And The Origins Of Its Information Age, Robert Howard Lass

Theses and Dissertations

The United States Air Force is an organization operationally focused on gathering, processing, and utilizing vast quantities of information, so much so that it added "cyberspace" to its core missions of air and space in 2005. Service leaders have argued that a USAF information revolution - its entrance into the "Information Age" - began as early as the first computers in the 1940s or as late as the proliferation of networks in the 1990s. Upon close inspection, however, it becomes clear that such assertions overlook decades of information operations and management, and overemphasize the concept of a single information age. …

Environmental Footprints Of Violent Conflict, Swapna Pathak

Theses and Dissertations

The effects of militarized conflict pervade countless aspects of society, yet scholars have focussed very little attention on the consequences of conflict. My dissertation assesses the cost of war by examining the relationship between violent conflict and the environment. I argue that the effect of conflict on the environment is an im- portant consequence of war that is often overlooked in favor of other repercussions such as economy and health that are more politically expedient . I study this effect in the light of components of national environmental capacity and hypothesize that conflicts result in short-term and long-term impact on …

Modeling Ultrasonic Field Emanating From Scanning Acoustic Microscope For Reliable Characterization Of Pathogens (Biological Materials), Rowshan Ara Rima

Theses and Dissertations

Acoustic microscopy provides extraordinary advantages over state-of-the-art invasive imaging techniques to determine the mechanical properties of living colonies of pathogens and micro-organisms. It is possible to obtain the morphomechanical parameters of the pathogenic colonies e.g. variation of thickness, stiffness and the coefficients of attenuation, using scanning acoustic microscope (SAM). However, the process requires an expert with extensive understanding of SAM and ultrasonic signals which is very time consuming and expensive for complex form of analysis. Due to lack of a suitable computational tool, presently the ultrasonic wave scattering, reflection and transmission through the biological specimens cannot be properly visualized. Without …

Modeling Hiv-1-Associated Neurocognitive Disorders And The Therapeutic Effects Of The Phytoestrogen Metabolite S-Equol In The Hiv-1 Transgenic Rat, Landhing Mary Moran

Theses and Dissertations

HIV-1 associated neurocognitive disorders (HAND) continue to afflict individuals with HIV-1 in the combination antiretroviral treatment (cART) era, most notably affecting executive function, as well as preattentive processing. Currently, there is no effective treatment for HAND, with only adjunctive treatment targeting symptomatic relief. There were two hypotheses in this dissertation: 1) that HIV-1 Tg rats will show disruptions in measures of executive function and preattentive processing, as well as neural network alterations in the prefrontal cortex (PFC), a brain region implicated in executive function, and 2) that administration of the phytoestrogen metabolite S-equol will improve performance as measured by executive …

Identity Crisis And The Emergence Of The Picaresque In Literature From Early Modern Spain And Twentieth Century Argentina, Mary Johnson Shepherd

Theses and Dissertations

The picaresque genre and character appeared in what is considered the first modern novel, Lazarillo de Tormes, which was published anonymously in 1554, when Spain was on the cusp of a slow transition out of feudalism. The pícaro has continued to appear in literature across regions and epochs. This thesis looks at the socio-ideological factors that give birth to picaresque identity and behavior, as well as the verisimilitude of fiction in relation to reality. The first part of this study is dedicated to the Spanish picaresque tradition and focuses on the universal qualities of the literary figure and genre, as …

The Use Of Ultrasound As An Adjunct To X-Ray For The Localization And Removal Of Soft Tissue Foreign Bodies In An Urgent Care Setting, Stacy Lane Merritt

Theses and Dissertations

Embedded soft tissue foreign bodies are common complaints of patients presenting to rural urgent care centers. The removal of soft tissue foreign bodies present challenges for the healthcare provider when objects are radiolucent and cannot be identified on readily available diagnostic imaging modalities such as plain radiographs (X-rays). Ultrasound has been introduced in the literature as a useful adjunct to X-rays for the localization and removal of soft tissue foreign bodies. The purpose of this research utilization project was to report the use of bedside ultrasound by healthcare providers as an adjunct to X-ray for the localization and removal of …

The Effect Of Radiation On Myofiber Properties In Mouse Skeletal Muscle, Dennis K. Fix

Theses and Dissertations

Radiotherapy has been proven as an effective and necessary treatment for cancer. The dose given is dependent on cancer type and location. It has been previously established that skeletal muscle is the most radiation tolerant tissue in the body. With that being said there is a current gap in the literature that is missing the effect of radiation doses on the histological properties of skeletal muscle. The overall purpose of this study is to determine the effect that a single unfractionated dose of 16Gy radiation has on histological properties of myofibers when compared to 4 fractionated doses of 4Gy . …

Using Multivariate Pattern Analysis To Investigate The Neural Representation Of Concepts With Visual And Haptic Features, Laura Bradshaw Baucom

Theses and Dissertations

A fundamental debate in cognitive neuroscience concerns how conceptual knowledge is represented in the brain. Over the past decade, cognitive theorists have adopted explanations that suggest cognition is rooted in perception and action. This is called the embodiment hypothesis. Theories of conceptual representation differ in the degree to which representations are embodied, from those which suggest conceptual representation requires no involvement of sensory and motor systems to those which suggest it is entirely dependent upon them. This work investigated how the brain represents concepts that are defined by their visual and haptic features using novel multivariate approaches to the analysis …

Toward Directing Cell Fate: Carbon Nanotubes As Modulators Of Extracellular And Transporters Of Intracellular Cues, Qingsu Cheng

Theses and Dissertations

The unique properties of CNTs lead CNTs attractive in biological engineering applications. It is expected to use CNT based biomaterials for clinic use in the near future. CNTs can be used to tune cellular fate through bother extracellular pathway and intracellular pathway. CNT based biomaterials has been applied into bone, nerves, and cardiovascular system. There has also been progress in the use of CNTs in controlling cellular alignment, to enhance tissue regeneration, growth factor delivery and gene delivery.

Pluripotent stem cells (hPSCs) offer a promising tool in tissue engineering strategies, as their differentiated derivatives can be used to reconstruct most …

The Effect Of Cancer Cachexia Severity And Eccentric Muscle Contractions On Selected Myofiber Metabolic Properties In Mouse Skeletal Muscle, Joshua Earl Mangum

Theses and Dissertations

Cancer cachexia is a complex syndrome that induces skeletal muscle wasting and dysregulation of skeletal muscle metabolism. Alterations in area of myofibers and myofiber metabolic properties can significantly impact the function of skeletal muscle. The purpose of this study was to examine the effect of cachexia severity and resistance exercise training on frequency and area of selected myofiber metabolic characteristics during cachexia-induced myofiber atrophy. Male ApcMin/+ (Min) mice were studied during the progression of cachexia (16-20 weeks of age) and stratified into groups based on the severity of cachexia. For the second study, male Min mice performed resistance exercise (RE) …

Antecedent Topicality Affects The Processing Of Both Np Anaphors And Pronoun, Evgenia Borshchevskaya

Theses and Dissertations

Information structure and grammatical constraints are known to affect the salience of discourse referents and referential processing, but it is not clear whether the two types of constraints have comparable effects. We report two visual-world experiments that contrasted the effect of a grammatical constraint (subjecthood) and the effect of an information structure constraint (fronting) on processing noun and pronoun anaphors. Experiment 1 tested whether fronting a non-subject referent can eliminate the Repeated Name Penalty (RNP; Gordon et al., 1993) when referring to the subject. Experiment 2 tested whether fronting a non-subject referent can elicit the RNP. The results show that …

Experimental Study On Piping Failure Of Earthen Levee And Dams, Yusuf Ahmed Sharif

Theses and Dissertations

Piping in an earthen levee, one of the main causes of failure, is a complex phenomenon. Most of the available research on piping failure has been on non-cohesive sandy soils. Jet Erosion Test and Hole Erosion Test have been conducted to study piping failure in an indirect manner. However, no general purpose formula is presently available to describe the erosion process due to complex erosion characteristics of cohesive soils in earthen levees.

Experimental investigations in a flume to understand the piping erosion process in an earthen levee are conducted in this research. One of the sidewalls and the bottom of …

Forgotten Russian Piano Music: The Sonatas Of Anatoly Aleksandrov, Irina Pevzner

Theses and Dissertations

This historical and analytical study focuses on the piano sonatas of Anatoly Aleksandrov (1888-1982), the longest-living Russian and Soviet composer-pianist of the twentieth century. The fourteen piano sonatas, written between 1922 and 1971, reflect not only the composer's evolution of style, but also reveal the vast array of influences which characterize the music of the twentieth century. Chromaticism that results from stretched harmonic sequences, strong melodic lyricism that threads these epic compositions, rich writing for piano, and hints of Russian folklore all contribute to the composer's original style, which synthesizes Aleksandrov's four main figures of influence, namely Rachmaninov, Scriabin, Medtner, …

Best Practices/Teaching Strategies For Teaching Reading In The Primary Grades, Kate Birney

Theses and Dissertations

No abstract provided.

El Rol De La Cultura Visual En El Desarrollo De Una Nueva Espacialidad En La Literatura Argentina, Maria Paula Rivero

Theses and Dissertations

This work explores the use of visual culture in Horacio Quiroga's 'La c├â┬ímara oscura', Julio Cort├â┬ízar's 'Apocalipsis de Solentiname', and Rodolfo Walsh's 'Fotos', focusing on its role in the development of a new conceptualization of the argentine space. The visual culture in these short stories, represented through the art of photography, gives the reader a new way of access into a national space that has been historically established by a politically dominated narrative. While the past rhetoric has been characterized by recognizing the territory as empty and assigning it the preferred meaning, these short stories revert such mechanism by developing …

Ruminating On Ruminants: Goats And The People Who Raise Them In South Carolina, Brianna Dyan Farber

Theses and Dissertations

In South Carolina, many farmers and homesteaders have utilized goats as an adaptive and versatile resource and component of their diversified farming operations. This thesis addresses the experiences, motivations, difficulties, and successes of people raising goats in South Carolina, in the context of sustainable agricultural practice and landscapes. Goats cohabit insecure but promising ecological, political, economic, and sociocultural landscapes with humans and other nonhuman species. These relationships can undermine and support goats as belonging in South Carolina. My participants cannot simply raise goats as a purely economic choice because they create meaningful emotional relationships with their animals. Goats can become …

The Function Of A Middle Woodland Site In The Central Illinois Valley: A Ceramic Study Of Ogden-Fettie, Montana L. Martin

Theses and Dissertations

Ogden-Fettie is a Middle Woodland Havana-Hopewell mound group in the Central Illinois Valley. Fv196 is the midden area near the largest mound. The function of Fv196 was in question, because it does not conform to the settlement and function models that have been applied to other sites. The ceramic collection from Fv196 was typed and categorized into categories based on perceived function, either habitation or ceremonial. The majority of the pottery belonged to the Havana series, which is traditionally considered habitation pottery; however, many of the Havana sherds were decorated indicating a ceremonial function. The highly decorated pots showed the …

Early Adolescent Nicotine Exposure Has Long-Lasting Effects On Cocaine-Induced Behaviors In Mice, Mai Alajaji

Theses and Dissertations

Nicotine is one of the most commonly used drugs among adolescent populations. Given the fact that adolescence is a unique developmental stage, during which nicotine has long-term effects on future drug-taking behavior, it is essential to understand how early exposure to nicotine during adolescence may affect the abuse liability of other drugs. We hypothesize that repeated exposure to low doses of nicotine in adolescence induce age-specific enhancement of the rewarding effects of several drugs of abuse in the conditioned place preference (CPP) test. Furthermore, we predict that these changes in behavioral responses are mediated by nicotine-induced brain region-specific increases in …