Digital Commons Network^™

A Techno-Economic Study For Heating Poultry Houses Using Renewable Energy, Heidi Elzanaty

Theses and Dissertations

In any broilers poultry house, fuel-based heating systems are commonly used to maintain the targeted temperatures for successful breeding of chicken. A considerable amount of fuel is consumed for this application, which leads to high running cost and contributes to the increase of air pollutant emissions. Given the current energy crisis and the urge to use renewable energy, this research studies the application of a solar heating system (SHS) for a poultry house. It includes the technical and economic study for the SHS and the integration of biogas produced from chicken manure as an auxiliary source of heat. The heating …

The Effects Of Using Smartboard And Interactive Games To Improve Reading Comprehension Of Secondary Students With Moderate Cognitive Disabilities, Melissa Coyle

Theses and Dissertations

This study investigated the effects of using the Smartboard and interactive games to improve reading comprehension skills of secondary students with moderate cognitive disabilities. A total of 11 9th and 10th graders in a special services school participated in the study. A single subject design of ABC phases was used. During the baseline (Phase A), student listening comprehension was evaluated by their scores of correct responses to "Wh" questions on their paper. During intervention (Phase B), the teacher used the Smartboard and Boardmaker software to present fiction and nonfiction stories. Each session included the student listening to the story, read …

A Direct And Indirect Mechanism For Ccr5 In Morphine And Hiv-1 Mediated Neurodegeneration, Elizabeth Podhaizer

Theses and Dissertations

A DIRECT AND INDIRECT MECHANISM FOR CCR5 IN OPIOID AND HIV-1 MEDIATED NEURODEGENERATION By Elizabeth M. Podhaizer, Ph.D. A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at Virginia Commonwealth University. Virginia Commonwealth University, 2014 Major Director: Kurt F. Hauser, Ph.D., Professor of Pharmacology & Toxicology Human immunodeficiency virus (HIV)-1 infection currently affects over 34 million people worldwide, and despite the use of cART, the prevalence of HIV-1 associated neurocognitive impairments (HAND) has not declined. Additionally, other co-morbid factors such as the abuse of injection drugs (i.e. heroin, morphine) increase both the frequency …

Regulation Of Growth And Stress Tolerance In Tomato Plants By Expression Of A Dominant-Negative Version Of Erecta Gene From Arabidopsis Thaliana, Hector Ernesto Villagarcia

Theses and Dissertations

Receptor kinases are the main group of signal recognition structures in plants. The large number and diversity of these receptors suggest that they perform major roles in a complex regulatory network of growth, development, and physiological responses. The ERECTA gene is a leucine-rich, receptor-like kinase that affects plant growth rates, stomatal patterning, transpiration efficiency, bacterial pathogen resistance, inflorescence and floral organ morphology, and leaf polarity. The ability to manipulate the ERECTA pathway in members of the Solanaceae family can reveal fundamental mechanisms including regulation of fruit and tuber development. This knowledge may enable changes in plant architecture and growth rates …

The Accurate Productions Of Emotion Words During A Social Communication Intervention In Children With Language Impairment, Emily Marie Gibbons

Theses and Dissertations

This thesis examines a social communication intervention that targets the emotional competence of children with language impairment (LI). Three elementary school-aged children with LI received twenty, 20-minute intervention sessions over four months. Each intervention session involved a combination of activities targeting emotion recognition and emotion inferencing. The emotion-based word productions were counted and analyzed. Categorized words belonged to the emotional categories of happiness, sadness, anger, fear, surprise, and disgust. The percentage of appropriate usage was calculated to represent how often the participants used each emotion-based word in a semantically correct manner. Emotion word productions that did not match the intended …

The White Women's Experience In Arkansas During The American Civil War, Ellen M. Lewis

Theses and Dissertations

When war came to Arkansas there were few, if any, troops left in the state. As a result the women were left to defend themselves. While economics and geographic location were responsible for the culture of the women, it was the individual fortitude that made survivors of the female population. Arkansas was very diversified and so were the women. When Union soldiers occupied the state they interacted with the women in many different ways, from pleasant social activities to barbaric terrorism. When Confederates occupied regions of the state, they also met a variety of women and had just as varied …

Studies On Theraputic Potential Of Dichloroacetic Acid And Hene Laser In Cancer Treatment: Understanding The Mechanism Of Action, Zeiyad Nassaif Al-Karakooly

Theses and Dissertations

Cancer cells are often characterized by anaerobic glycolysis due to dysfunctional mitochondria that limits pyruvate uptake for aerobic respiration. Dichloroacetic acid (DCA), used in this study as a potential cancer treatment agent, targets mitochondria in cancer cells and is likely to correct mitochondrial dysfunction by resuming pyruvate uptake and therefore normal aerobic respiration. Our results suggest that DCA causes a significantly higher cytotoxicity in aggressive MCF-7 breast cancer cells than in non-aggressive MC3T3 osteoblastic cells. Apparently lower doses of DCA induce apoptosis whereas higher doses lead to non-specific cytotoxicity or necrosis. Increased cytotoxicity might be related to oxidative stress due …

Targeting The Endocannabinoid Metabolic Enzymes To Reduce Inflammatory Pain, Sudeshna Ghosh

Theses and Dissertations

Pain is a debilitating condition that presents a problem of clinical relevance. Common analgesics include opioids and non-steroidal anti-inflammatory drugs (NSIADs). Despite different degrees of effectiveness, a major drawback of these analgesic classes is their side effects. For example, side effects associated with opioids include pruritus, respiratory depression, hyperalgesia, constipation, dependence. In addition, chronic use of NSAIDs can cause gastric ulcers. Delta-9 tetrahydrocannabinol (THC), the primary psychoactive constituent of marijuana, produces antinociception in various preclinical models of pain. Similarly, many synthetic cannabinoid receptor agonists produce antinociception in preclinical models of pain. However, their psychomimetic effects dampen interest for their therapeutic …

Combined Antiproliferative Effects Of The Aminoalkylindole Win55,212-2 And Radiation In Breast Cancer Cells, Sean Emery

Theses and Dissertations

The potential antitumor activity of mixed CB1/CB2 cannabinoid receptor agonists, such as the aminoalkylindole WIN55,212-2 (WIN2), has been extensively studied, but little information is available as to their potential interaction with conventional cancer therapies, such as ionizing radiation (IR). In the present work, we investigated the effects of WIN2 on the antiproliferative effects of radiation in human (MCF-7 and MDA-MB-231) and murine (4T1) breast cancer cells, as well as an immortalized human breast epithelial cell line (MCF-10A). WIN2 or radiation alone inhibited breast tumor growth, while the combination of WIN2 and radiation was more effective than either agent alone in …

An Analysis Of The Cause, Effect & Control Of Hyperlipidemia From A Nursing Perspective, Melissa Rodgers

Theses and Dissertations

Two of the top four causes of death worldwide, heart disease and stroke, are related to hyperlipidemia, elevated cholesterol levels; these two illnesses account for approximately seventeen million deaths each year (World Health Organization, 2014). In order to combat the prevalence of these illnesses, the National Cholesterol Educational Panel has issued guidelines regarding cholesterol management. Extensive research has been published concerning cholesterol management. However, a gap remains between evidenced-based practice and community awareness of this phenomenon. This manuscript compiles research from peer reviewed nursing journals and acclaimed government and national organizations to express the cause, effect, and control of hyperlipidemia …

The Effect Of Lactic Acid On Mast Cell Function, Andrew J. Spence

Theses and Dissertations

This study shows for the first time the effect that L-(+)-lactic acid has on mast cell activation. Lactic acid is a byproduct of anaerobic glycolysis and is associated with inflammatory environments such as wounds, tumors and, asthma. In this study, pre-treatment with lactic acid altered cytokine production by bone marrow-derived mast cells (BMMC). Specifically, lactic acid enhanced cytokine secretion following IgE cross-linking, but decreased IL-33 mediated cytokine production. These effects were altered by genetic background, since C57BL/6 mast cells demonstrated the aforementioned result, but lactic acid had no effect on IgE-mediated cytokine production in 129/SvJ mast cells. The affected cytokines …

Regulation Of Proline-Directed Phosphorylation Site, Threonine 53 On Dopamine Transporter, Sathyavathi Challasivakanaka

Theses and Dissertations

The dopamine transporter (DAT) is a plasma membrane protein that clears extraneuronal dopamine (DA) and thus controls the spatio-temporal dynamics of dopaminergic neurotransmission. Also, DAT is the major target for psychostimulant substrates, amphetamine (AMPH) and methamphetamine (METH), and psychostimulant uptake blocker, cocaine (COC). DAT is a phosphoprotein with both the N- and C-termini facing toward the cytosol, with multiple phosphorylation sites on the N-terminus. DAT has a closely spaced 6-serine cluster on the distal N-terminus that is phosphorylated in a protein kinase C (PKC)-dependent manner and a recently identified proline-directed site, Thr (T) 53, that is phosphorylated in vitro by …

School Racial Climate And The Academic Achievement Of African American High School Students: The Mediating Role Of School Engagement, Charity Brown Griffin

Theses and Dissertations

African American students in K-12 education experience pervasive disparities in academic outcomes across all areas of the schooling experience. In order to understand the factors that promote academic achievement among individuals who face adversity, researchers have sought to examine how school environmental factors hold influence over students' academic adjustment. Drawing from an integrative model of development for ethnic minority children and a process model of engagement, this investigation explored whether three dimensions of school engagement, behavioral, emotional and cognitive, mediated relationships between school racial climate and academic performance and educational aspirations. These relationships were explored in a sample of 139 …

Claude Debussy: Harmonic Innovations In Historical And Musical Context, Ford Joseph Forqurean

Theses and Dissertations

Claude Debussy's music developed as a product of his environment and culminated in the creation of a unique harmonic vernacular that permeates the twentieth century's tonal language. Through a historical and musical context, his early life through his formative years as a composer will be examined as a natural progression of his environment. The first section of this work will discuss these developments while the second part will analyze the structure and form of the Premiere Rhapsodie for clarinet and piano to illustrate the culmination of this trajectory.

Late Romanticism pushed tonality to its breaking point. Composers were forced to …

Characterizing Wetland Hydrology, Chemistry, And Soils For An Endemic Crayfish, The Piedmont Blue Burrower, Jess H. Gilmer Ii

Theses and Dissertations

Anthropogenic alteration of Earth's ecosystems has pushed global biodiversity into a state of crisis. Freshwater species have been particularly vulnerable, with crayfish ranking as the second most imperiled taxonomic group in North America. Primary burrowers represent only 15% of crayfish species in North America; however, they constitute 32% of imperiled crayfish. Despite their conservation importance, little is known about the ecology of burrowing crayfish. To advance our knowledge about the habitat characteristics of burrowing crayfish, groundwater hydrology, water chemistry, and soil properties were assessed to determine their importance for the state-listed endangered, primary burrower Cambarns harti. Groundwater hydrology and …

"Man, Who Parts The Windblown Grasses", And Other Stories, Ryan Kennerly

Theses and Dissertations

"Man, who Parts the Windblown Grasses," and Other Stories is a collection of short fiction based on common themes of violence, loss and grief, and humanity's struggle to reconcile the primal demands of the id with the desires and restrictions of the superego. Written from many different perspectives, representing all manner of walks of life, the collection seeks to question the ways in which violence is presented, defended, and understood, and what that means for humanity as a species.

Critical Editions And Comparative Analysis Of Three Representative Wind Band Works From The French Revolution, Adam Gary Kehl

Theses and Dissertations

The French Revolution witnessed the greatest output of music for wind band before the twentieth century. The importance of wind bands and wind repertoire grew for several reasons including, most notably, their participation in government sponsored outdoor national festivals. Festival celebrations were large gatherings in which wind band music was a central component. The French National Guard Band was the dominant musical ensemble in revolutionary France; its leaders, François Gossec, Bernard Sarrette, and Charles-Simon Catel, were among France's most important musical figures between 1789-1799. These men, in combination with music schools established in Paris during the Revolution, helped shaped the …

Identifying Identity: An Archaeological Investigation Of The Intersection Of Place And Identity At An African American Lowcountry Site, Katherine Elisabeth Goldberg

Theses and Dissertations

African and African American communities have faced pressures of marginalization and racism in the South Carolina Lowcountry since their arrival with Europeans in the seventeenth century. These pressures have been felt physically, socially, economically, politically, and even academically, through misrepresentations in historical portrayals. The field of historic archaeology is uniquely situated with access to informative sources from both the past and the present, and as such exhibits great potential in taking strides to replace the limiting presentation of a static and homogenous single African American culture with views that instead emphasize a focus on unique cultures and identities. This thesis …

Identifying Performance Criteria Of Fully Bioresorbable Scaffolds For Endovascular Applications, Jahid Ferdous

Theses and Dissertations

Background: Bioresorbable scaffolds (BRS) have revolutionized percutaneous coronary intervention in clinical cardiovascular medicine. As opposed to permanent alternatives such as metallic stents, BRS have an inherent potential to reduce the occurrence of untoward events such as vessel re-narrowing or thrombosis by virtue of undergoing complete and controlled resorption post- implantation. While BRS platforms demonstrate a clear potential to mitigate risk stemming from incomplete vessel healing, they introduce a new set of considerations to clinical safety and efficacy. Foremost among these issues is the fate of and biological response to material by-products that evolve throughout the scaffold degradation and erosion processes, …

A Multiagent Approach Towards Solving Complex Problems Of Sociotechnical Systems, Hongying Du

Theses and Dissertations

Complex resource allocation problems arise due to complex human societies and scarce resources to be distributed. Scarce resources could be food, water, and energy. Meanwhile, the size of the problem, the intersection of different areas, and possible global consequences all add to the complexity of the problems, which makes it difficult for humans to solve the problems by themselves.

For all these reasons, humans need technical help to tackle complex problems. Since humans participating in the problems usually own part of the information about the problems, and no one may see the whole picture of the problems, it is natural …

The Effects Of Snmp-2 Gene Expression On Mating Discrimination In Male Drosophila Melanogaster, Kristen Taylor Ashourian

Theses and Dissertations

In order to distinguish between relevant and extraneous stimuli, insects have adapted specialized processes to perceive cues that are beneficial for survival and proliferation. Volatile molecules in the environment can stimulate olfactory receptors (ORs) and gustatory receptors (GRs) in chemosensory organs called sensilla. Specialized proteins located within these sensilla guide and assist chemosensory molecules to the receptors, which then trigger a transduction pathway that elicits behavioral responses. Sensory Neuron Membrane Proteins (SNMPs) are transmembrane proteins found on both gustatory and olfactory sensory organs in insects. There are two forms of these proteins, SNMP-1 and SNMP-2. InDrosophila melanogaster, the function of …

Isolation Of Natural Nrf2 Activators From American Ginseng, Akrm Abdalrahman

Theses and Dissertations

Nuclear factor erythroid-2 related factor 2 (Nrf2), a major transcription factor of the endogenous antioxidant defense system, has been proposed as a potential therapeutic target for the treatment of various diseases. However, a small molecule-driven Nrf2 signaling therapeutic approach remains to be established. Herein, we report one such possibility discovered by the bioassay-based fractionation of American ginseng. Since crude extract of American ginseng was found to suppress the expression of inducible nitric oxide synthase (iNOS) in lipopolysaccharide (LPS)-inflamed macrophages via activating Nrf2, we further fractioned the crude extract using solvents including hexane, dichloromethane, ethyl acetate, butanol, and water, and found …

Understanding Hydrothermal Carbonization Of Mixed Feedstocks For Waste Conversion, Xiaowei Lu

Theses and Dissertations

Hydrothermal carbonization (HTC) is an environmentally beneficial means to convert waste materials to value-added solid and liquid products with minimal greenhouse gas emission. Research is lacking on understanding the influence of critical process conditions on product formation and environmental implication associated with HTC of waste streams. This work was conducted to determine how reaction conditions and heterogeneous compound mixtures (representative of municipal wastes) influence hydrothermal carbonization processes. The specific experiments include: (1) determine how carbonization product properties are manipulated by controlling feedstock composition, process conditions, and catalyst addition; (2) determine if carbonization of heterogeneous mixtures follows similar pathways as that …

Comparative Recharge Rates Of Isolated And Riverine Wetlands, Chenille Hargrove Williams

Theses and Dissertations

Isolated wetlands have a slightly depressed topography surrounded by an upland area. There is no direct surface water connection, as with riverine wetlands; however, there is a groundwater connection that allows isolated wetlands to have similar hydrologic functions to riverine wetlands. This study sought to compare surficial aquifer groundwater recharge rates of several isolated and riverine wetlands in the Coastal Plain of the Carolinas by evaluating soil characteristics, water table fluctuations, and precipitation from January 2012 - September 2012. Data analysis indicated no significant difference in mean recharge rates between the isolated and riverine wetlands at each study site. Whereas …

Discovery And Characterization Of Multi-Target Directed Ligands As Inhibitors Of Amyloid-Β Aggregation And Regulators Of Alzheimer's Disease, Jui-Heng Tseng

Theses and Dissertations

Alzheimer's disease (AD) is the most common neurodegenerative disease in the world. As the disease advances, symptoms include confusion, language skill breakdown, and long term memory loss - and culminate in death. Existing therapies for AD provide symptomatic benefits but cannot halt or slow the disease pathogenesis.

Increasing evidence reveals the multi-factorial nature of AD. Numerous factors, including amyloid-β (Aβ) aggregation, calcium homeostasis dysregulation, and oxidative stress, contribute to disease development and interplay with each other. Therefore, multi-target directed ligands (MTDLs) may present an effective AD treatment. Among all factors, Aβ aggregation is suggested to play the most crucial role. …

Antibiotic Usage In Relation To Resistant Bacterial Infections And Liver And Kidney Cancer Outcomes In South Carolina, Prea Thathiah

Theses and Dissertations

Antibiotics are one of the most beneficial discoveries in medicine and public health. However, the use, overuse, and misuse of these drugs have led to increases in antibiotic resistant bacterial infections (ARI). Furthermore, previous epidemiological studies have linked antibiotic use to breast cancer, but these studies have not included effects on metabolic organs, such as the liver and kidneys. This dissertation investigates the role of antibiotic use in infections and liver and kidney cancers in the state of South Carolina. Using ecological study methods and Poisson regression to determine relative risk ratios, it was found that antibiotic use is a …

Costume Design: More Than Imagination, Sean Anthony Smith

Theses and Dissertations

Through an analysis of my Costume Design process for Present Laughter by Noel Coward (2012), King Lear by William Shakespeare (2013) and Arcadia by Tom Stoppard (2014), presented at the University of South Carolina, I hope to relay the experience I gained as an artist and student. By examining my journey from an undergraduate design student, to graduate design student, and finally as an intern with William Ivey Long, I will analyze my work as a Costume Designer.

Mitochondrial Replication From Embryogenesis To Early Adulthood, In Dui Species, Mytilus Galloprovincialis, Ellen Blenn Richardson

Theses and Dissertations

Eukaryotes typically inherit mitochondria strictly maternally. There are however a group of bivalve molluscs that inherit different mitochondrial genomes from each parent. The paternally inherited mtDNA (M-type) is localized to, and dominates over the maternally inherited mtDNA (F-type) in the gonads of the male offspring, but is not normally retained in any tissue of the female offspring. This process is termed Double Uniparental Inheritance (DUI). Using quantitative PCR (qPCR), this study examines mtDNA replication compared to total DNA replication through embryonic stages of development and into early adulthood of the DUI species, Mytilus galloprovincialis. Results indicate that up through the …

The Culture And History Surrounding “Szomorú Nόták” Of Béla Bartόk’S Twenty Hungarian Folksongs And Its Influence On Bartók’S Settings, Mary Katherine Rawls

Theses and Dissertations

This document is an exploration of the Hungarian culture and history as it pertains to "Somorú nótak" of Bartók's Twenty Hungarian Folksongs. The information presented will provide insight into the Magyar, Hungarian, outlook as well as relevant themes. As a performer, it is important to make these connections and apply them to the musical setting so that a genuine portrayal of the texts and their emotions is possible. Hungarian history, the folksong as it pertains to the Hungarians, and the process by which these songs were composed are discussed in order to establish their importance and background of the content. …

The Regulation Of Skeletal Muscle Mass And Mitochondrial Biogenesis By Gp130/Stat3 Signaling During Cancer Cachexia, Melissa Puppa

Theses and Dissertations

Cachexia affects nearly 70% of all cancer patients depending on the cancer, and decreases cancer survival. Cachexia is associated with muscle mass loss that is accompanied by a loss in muscle oxidative capacity, a decrease in protein synthesis and an increase in protein degradation. While progress has been made in understanding some of the mechanisms underlying the cachectic condition, there are currently no approved pharmaceutical interventions to slow or stop cachexia progression. The purpose this study was to determine the role of skeletal muscle gp130 and STAT3 signaling in the regulation of cachexia induced muscle atrophy and mitochondrial loss. Specific …