Digital Commons Network^™

Development Of Novel Hydrogel Materials For Viscoelastically Accurate Brain Phantoms, Lila G. Schandler

Theses and Dissertations

Current methods such as concussion tests and Magnetic Resonance Imaging (MRI) scans only reveal structural damage post-injury. Creating an anatomically accurate model of the brain that mimics brain structure and viscoelastic properties will further allow medical professionals to analyze concussion events and create curated and personalized plans of recovery for a patient’s unique brain injury.

Values have been established for the necessary viscoelastic properties (time constants and elasticity) to mimic the native human brain tissue such as grey matter and white matter. The mechanical properties of the hydrogel are tunable by varying the concentration of Phytagel (PHY), a protein binding …

Photovoice As A Reflective Pedagogy For Undergraduate Community Psychology Students, Shereé Bielecki

Theses and Dissertations

This descriptive qualitative study was designed to understand the experiences of former Community Psychology (CP) undergraduate students who participated in a degree program at a California university. The purpose of this qualitative study is to explore how former Community Psychology undergraduate students describe their experiences using reflective Photovoice activities to learn about and become involved in social justice. The theoretical frameworks that informed this study were in social justice theory, pedagogical practices related to teaching social justice using Photovoice, and the practice of self-reflection in college classrooms. Two primary research questions guide the inquiry: 1) How do former Community Psychology …

An Examination Of The Facilitators And Barriers For Implementing Environmental Sustainability Plans Into Corporate Strategy, Nathan Maton

Theses and Dissertations

This study examined how organizations integrate environmental sustainability and corporate strategy, describing that intersection as strategic sustainability. The goal of the study was to use qualitative interviews of public American corporations to understand the facilitators and barriers to strategic sustainability. The study identified three facilitators (i.e., emerging regulations, customer demand, and leadership) and two barriers (i.e., data quality and education). These results suggest corporations leverage upcoming regulations, leaders who advocate for sustainability, and customer demand to embed sustainability while improving their education and data quality. Additionally, the research suggests more quantitative research and validation of the results.

An Examination Of Emerging Technologies In Supply Chain Management And Their Impacts On Efficiency In The Automotive Industry, Wafaa A. Barakat

Theses and Dissertations

The automotive supply chain sector is facing immense transformation, particularly with the emerging digital technologies in supply chain management. This paper examines the emerging technologies in supply chain management and their impacts on efficiency in the automotive industry. This research strives to examine the underlying aspects of the automotive supply chain integration in United States companies. For the study, there is the application of the exploratory study. The reason is that there is no vivid perspective of the characteristics and the scope. The study design used is a qualitative analysis of 10 automotive personnel from different multipliers of the automotive …

I Am Who I Am, Yifei Kong

Theses and Dissertations

I am Who I am

By Yifei Kong, MFA

My thesis research focuses on my cultural background and history as a Chinese woman. I explore the control and restraint of women from ancient times and highlight feminism. Traditional Chinese hair accessories reflect a type of control over women. Unlike traditional Chinese hair accessories, which use a lot of precious metals and precious stones, my work uses recycled aluminum cans. That is an exploration of contemporary jewelry materials and a reflection of women's independent right to choose. With my pieces, women can use their preferred colors without considering their class and …

Frozen By Worry And Fatigue? A Mixed Methods Approach To Understanding The Lived Experiences Of Freezing Of Gait, Sarah M. Ghose

Theses and Dissertations

This study utilized a mixed methods emergent, phenomenological approach to (1) understanding the lived experience of freezing of gait for individuals diagnosed with Parkinson’s Disease and (2) determining the role of anxiety and sleep in freezing of gait outcomes. Participants included 13 adults diagnosed with Parkinson’s Disease (N=14 for qualitative data, N=13 for quantitative data; 23.1% female-identifying, 76.9% male-identifying) who were predominantly white (92.3%) with an average age of 69 years (SD = 6.73 years). Data collection consisted of semi-structured interviews, self-report measures, actigraphic sleep data, and salivary alpha amylase biomarker collection. Results are organized into …

“I Know What Nothing Means”: Nostalgia, Hope, And The Postmodern Search For The Sublime, Kathryn L. Donati

Theses and Dissertations

Amid simultaneous crises of self, nation, digital citizenship, global health, climate change, and socio-political polarization, to name but a few of the catastrophes that seem to define life in the global West in the twenty-first century, where do we find hope? Do we find it at all? Is there any hope to be found? These are the questions that serve as the genesis for this undertaking in which I locate the origin of these crises far before the events of the 2016 and 2020 elections, far before even the panic of Y2K. I begin my examination of hope in contemporary …

Using Natural Language Processing To Understand The Lived Experiences Of People Identifying With Adhd: What Themes Emerge In Social Media Posts?, Gabby C. Scalzo

Theses and Dissertations

Compared to the amount of research conducted on how to identify and understand children with Attention-Deficit Hyperactivity Disorder (ADHD), there has been relatively little work done to understand the lived experiences of adults with ADHD. Increased understanding of how adults with ADHD conceptualize themselves in the context of their diagnosis would help clinical experts tailor research and treatments to better serve these communities. However, there are several barriers towards conducting high-quality qualitative research, including time- and labor-intensity. This study, informed by qualitative research traditions, used innovative data sources (i.e., social media) and analytic techniques (i.e., machine learning) to reduce these …

Preexisting Conditionings: Painting, Gaming And Narrative Play, Pia Bakala

Theses and Dissertations

My work incorporates play, fantasy, and self-actualization through painting, sculpture, and video. In this essay, I will explore the ways in which my studio practice intersects with topics across fields of visual arts and in conjunction their theoretical frameworks. I will discuss the culminating body of work, tentatively titled Preexisting Conditionings, that my academic experience at VCU has fostered and trace its development across specific precursive works, as well as the cultural and intellectual touchstones influencing its creative impetus. In Preexisting Conditionings, I work primarily use oil painting, creating mostly representational figurative tableaus that correspond to narratives and characters I’m …

Biodistribution Comparison Of Fentanyl And Morphine Following Acute And Repeated Expsoure, Rosamond M. Goodson

Theses and Dissertations

The ongoing opioid crisis constitutes a dire public health threat that has resulted in staggering loss of life. In 2021, opioids were implicated in over 75% of the approximately 107,000 deaths attributed to drug overdose (CDC), and synthetic opioids such as fentanyl and its analogues are key drivers of the surge in opioid fatalities in recent years. Although fentanyl is a μ opioid receptor agonist, it has several distinct attributes compared to other drugs in this category, such as morphine. These include enhanced lipophilicity, heightened potency to induce respiratory depression, more rapid entry into the central nervous system, reduced sensitivity …

The Sexually Dimorphic Role Of Connexin 43 In Bone Remodeling And Disuse-Induced Bone Loss, Gabriel A. Hoppock

Theses and Dissertations

Bone loss is frequently experienced by individuals undergoing long-term disuse, such as prolonged bedrest, immobilization due to paralysis or injury, and conditions such as spaceflight. Under normal physiological conditions, bone remodeling is balanced by bone-forming osteoblasts and bone-resorbing osteoclasts, and the activity of osteoblasts and osteoclasts is orchestrated by osteocytes. Osteocytes are the most abundant cell type found in bone and ample evidence suggests they are bone’s main mechanosensory cell type. Therefore, understanding osteocyte biology and responses to mechanical signals, or lack thereof during unloading, may lead to new therapeutic targets to combat bone loss during disuse. Previous data has …

Few-Shot Learning For Ner Using Maml, Nourchene Bargaoui

Theses and Dissertations

This thesis investigates the application of Few-Shot Learning (FSL) using Model-Agnostic Meta-Learning (MAML) to enhance Named Entity Recognition (NER) within the domain of Natural Language Processing (NLP), specifically focusing on chemical datasets. The primary challenge addressed is the impracticality of relying on extensive annotated datasets, especially in specialized fields like chemistry. The research primarily explores the concept of Few-Shot Learning, aiming to train models on minimal data while maintaining performance across diverse tasks. It delves into the N-way K-shot methodology, where "N" represents the number of classes and "K" signifies the number of examples per class. This approach is further …

Spatial Transcriptomics Unravels Palmitoylation And Zonation- Dependent Gene Regulation Of Aeg-1 In Mouse Liver, Alissa Saverino

Theses and Dissertations

Obesity-induced metabolic dysfunction-associated steatohepatitis (MASH) leads to hepatocellular carcinoma (HCC). Astrocyte-elevated gene-1/Metadherin (AEG-1/MTDH) plays a key role in promoting MASH and HCC. AEG-1 is palmitoylated at residue cysteine 75 (Cys75) and a knock-in mouse representing mutated Cys75 to serine (AEG-1-C75S) showed activation of MASH- and HCC-promoting gene signature when compared to wild-type littermates (AEG-1-WT). The liver consists of 3 zones, periportal, midlobular, and pericentral, and zone-specific dysregulated gene expression impairs metabolic homeostasis in the liver, contributing to MASH and HCC. Here, to elucidate how palmitoylation influences AEG-1-mediated gene regulation in regards to hepatic zonation, we performed spatial transcriptomics (ST) in …

Expect: A Speculative Documentary Filmed In Vr Utilizing The Role-Playing Method To Explore Disabilities And Ableism In Science Fiction, Leilei Xia

Theses and Dissertations

Expect is a speculative documentary filmed in Virtual Reality (VR) that features Chinese actors with disabilities to explore, challenge and reimagine the conventional ableist Sci-Fi tropes and the transhumanistic tendency to “fix” or eradicate disabilities through technological enhancement. I invited people with disabilities who are interested in Sci-Fi to do a Role-Playing with me in Virtual Reality (VR), in which they imagine themselves to be living in a future civilization, an alien planet, or an alternate universe. The participants came up with their own fictional characters and built their own world views. I interacted with them by asking questions and …

Levofloxacin Incorporated Extracellular Matrix Nanoparticles For Pulmonary Cystic Fibrosis Infections, Raahi Patel

Theses and Dissertations

Cystic fibrosis (CF) is a progressive genetic disorder that affects around 40,000 people in the United States. CF is characterized by a mutation in the CFTR protein that causes dysregulated ion transport across epithelial cells, producing viscous mucus in the lung that increases bacterial invasion, causing persistent infections and subsequent inflammation. Pseudomonas aeruginosa and Staphylococcus aureus are two of the most common infections in CF patients that are resistant to antibiotics. One antibiotic approved to treat these infections is levofloxacin (LVX) that functions to inhibit bacterial replication, but can be further developed into tailorable particles. Nanoparticles are an emerging inhaled …

Beyond The Veil: Hijabi Superheroes And The Power Of Representation, Moom Thahinah Ms

Theses and Dissertations

As a Hijabi woman, I am often misrepresented by stereotypical narratives in Western media that obscure my individuality and agency. My thesis addresses the misrepresentation of Hijabi women, challenges audience perceptions, and empowers Hijabi women to confront these narratives.

Informed by design and media discourse, I developed a narrative and a Hijabi superhero character appropriating tropes of Western comic books. The resulting research combines two outcomes: a print-based narrative and a transformative garment. Print media is used to address the lack of Hijabi representation in Western comics while showcasing the character’s ability to combat discrimination. Derived from the comic format, …

In Shame I Will Find Paradise, Taehee Whang

Theses and Dissertations

As a Korean American non-binary digital artist and designer, my recent explorations have focused on using voice as a medium to articulate nuanced feelings of displacement and the intricate relationships between language, identity, and expression. This journey expands beyond my personal experiences with gender dysphoria, delving into the lives of non-binary and transgender individuals undergoing gender-affirming voice therapy. Through my thesis research, I have developed interactive multimedia installations inspired by dialogues with individuals such as Umico Niwa, who traveled to Korea for voice feminization surgery, and Jeong Yoon Lee from Hyperlink Press, a four-year participant in Hormone Replacement Therapy (HRT). …

Sense Make Before Book, Bradley Sinanan

Theses and Dissertations

“Sense Make Before Book” is an Indo-Caribbean turn of phrase which refers to common sense being more important than book smarts. My sister sent me a post the other day on Instagram of an Trinidadian woman using this phrase, saying it was one of Indo-Caribbean origin. I was interested and asked my mom about it. My mom says that when she was younger my grandpa said it often around their house in Princes Town, Trinidad and Tobago. This adage feels charged thinking about the history of indenture and its effects on the Indo-Caribbean diaspora.

The written word of archival history …

Investigations Of A Nox2 Activator, P47phox, Px Domain Membrane Anchoring Interactions And Inhibition, Angela Develin

Theses and Dissertations

The regulation of cellular signaling across plasma membranes is a well-organized process through cross-talk of biomolecules such as proteins and membranes. Peripheral membrane proteins (PMPs) are a class of water soluble, membrane associated, proteins that play a critical role in transducing such signals. Due to the dynamic nature of their membrane interactions, relatively smooth surfaces, and general lack of deep ligand binding pockets, PMPs are commonly associated with an approximate 85% of the human proteome that is classified as ‘undruggable’ by current drug discovery methodologies. One such PMP, p47^phox, contains a PX domain which is essential in activation …

Politics Of Being A Lover: In Art, (Space) And Kink, Rabeeha Adnan

Theses and Dissertations

Politics of being a lover: in art, (space) and kink explores my relationship with my practice through observations and stories that draw parallels with romance and kink. Narrated as love affairs turned into complex commitment, it shuffles through logics of structural power, control, and communication in the context of praxis and art institutions.

Dune Dynamics- A Nature-Based Preschool, Aseel Alhaidari

Theses and Dissertations

Sustainability is a global issue that requires collaborative efforts. Environmental values and attitudes are shaped in adults by early exposure to nature. During the COVID-19 pandemic, remote learning increased the attention to nature-based learning from families and the press (Prochner, 2021).

Although many early childhood education approaches for the age group of 3-5 years recognize the importance of holistic development and focus on tailoring the learning experience to the developmental stage of young children, few emphasize the importance of integrating nature as one of the learning tools. Nature-deficit disorder in children means that children spend less time outdoors and in …

Exposing The Camera: The Pedagogical Possibilities Of Critical Camera-Based Arts Curriculum, Oscar Keyes

Theses and Dissertations

Cameras are a ubiquitous part of our everyday lives, especially in schools, found in students’ smartphones and state-of-the-art surveillance systems. This research project emerged from an iterative redesign process of a Photography for Art Education course, structured around the camera’s dual nature as a tool for creative expression and social control. While cameras have long been used to address social issues through documentary techniques; this critical eye can be turned onto the apparatus itself. This study drew heavily upon the historical work of Allan Sekula (1986), who observed how easier access to cameras resulted in both democratization (for the People) …

Double Jointed: Gendered Flexibility And The Overextended Self, Grace A. Bromley

Theses and Dissertations

This thesis explores compulsory domesticity and the impulse to overextend oneself, both pressures often associated with the construct of femininity. Through diving into my personal history, which includes growing up in a three-generational home of women, I explore mimesis as it functions in both the replication of identity and in terms of pictorial representation; specifically I address its relationship to gender, manifestation within the body, and the search for subjectivity through the process of making and thinking. In various forms of material explorations, I play with ideas of malleability, mimicry and “embedded” behaviors that are passed down and embodied in …

May Your Flight Be Smooth, The Wind Calm, The Cloud Safe, And The Sky Blue!, Kai Chuang

Theses and Dissertations

They were born in a port city, on an island. In their eyes, many things seemed like the water. Fluid, compound, and ambiguous. Those things shift shapes with their containers, blending with elements from various sources, carrying multiple meanings, images and interpretations.

The sea is deep and endless, similar to stories, quests and dreams.

The coastline is a constant dialogue among the land, the ocean, the wind, organisms, physics, the past, randomness, and chance…When they think about boundaries, they recall the coastline.

Side Effects, Shannon R. Kurzyniec

Theses and Dissertations

Through the exploration of the personal and social impacts of prescription medications on the human condition, I have discovered that the side effects of prescription medications on myself and others are much greater than I had ever anticipated. The deeper I dig into my subconscious, the further back I find that the impact was created. Most of us are taught at a young age to take medicine when we don’t feel well. Stomach ache, headache, sore throat, fever, even the imaginary boo boo is given a pill to cure. As we age we begin to reach for pills due to …

Clinical Outcomes Of Primary Anterior Esthetic Crowns In Pediatric Dentistry, Jenan Alahmad

Theses and Dissertations

Clinical Outcomes of Primary Anterior Esthetic Crowns in Pediatric Dentistry - A Prospective Cohort Study

By: Jenan Alahmad, BDS

A thesis submitted in partial fulfillment of the requirements for the degree of Master of Science in Dentistry at Virginia Commonwealth University.

Virginia Commonwealth University, 2024

Thesis Advisor: Parthasarathy Madurantakam, DDS, MDS, PhD

Department of Pediatric Dentistry

BODY

Purpose: This prospective cohort study aimed to compare the effectiveness of restoring maxillary anterior teeth in children (aged 3-6 years) with three different materials: Zirconia Crowns (ZC), Resin Composite Crowns (RC), and Pre-veneered Stainless-Steel Crowns (PVSSC). The study aims to assess the Oral …

A Preliminary Report Of A Randomized Controlled Clinical Trial Comparing Ferric Sulfate With Zin Oxide Eugenol And Non-Eugenol Based Material For Pulpotomy In Primary Molar Teeth, Sarah Balal

Theses and Dissertations

Purpose: This study aimed to evaluate the effect of eugenol and non-eugenol-based Zinc Oxide Eugenol (ZOE) cements on primary tooth pulpotomies where Ferric Sulfate (FS) is used as a medicament.

Methods: Children aged 3-7 years with dental caries in their primary molars that have clinical and radiographic diagnosis of reversible pulpitis and undergoing dental treatment under Oral Conscious Sedation (OCS) or General Anesthesia (GA) were recruited. Children were randomly assigned to receive either FS and ZOE (IRM) or FS and non-eugenol based (CAVIT). The outcomes were assessed based on failure rates of the materials separately for clinical or radiographic evidence …

Established Colonization Of Sneathia Vaginalis In A Mouse Model, Kailyn E. Turcios-Gonzalez

Theses and Dissertations

Sneathia vaginalis (Sv) is a gram-negative anaerobic bacterium associated with adverse reproductive outcomes. Sv can traverse the fetal membrane and damage epithelial cells in vitro by producing a pore-forming cytotoxin, cytopathogenic toxin A (CptA). To further understand the transition of Sv from normal flora to a pathogen, an animal in vivo model needs to be created to observe the preliminary ascending infection before we begin to study the effects on pregnancy. Experimentation was conducted to optimize mouse breed, bacteria administration methods, and other variables that arise when working in vivo. The C57BL/6 mouse strain displayed the most consistent …

Capiz Reborn: Preserving And Enhancing Traditional Philippine Shellcraft, Destarte A. Prieto

Theses and Dissertations

The capiz shell is a thin, translucent exoskeleton of a mollusk found in the Philippine Sea. Traditionally, capiz shells were made into window panes and home decor, used so widely they became an iconic part of Philippine identity. Today, the influx of cheap, mass-produced merchandise threatens the capiz shell industry. To encourage renewed interest and sustainable revival of this long-standing industry, my research demonstrates new possibilities for the capiz shell.

In reconstituting cast-off bits and shell trimmings to form a new capiz biomaterial, my work is informed by the three traditional techniques used by Philippine capiz artisans—sewing, welding and bonding. …

Call For Me When You Get There: I'Ll Be Among The Crows, Jessica O. Tifase

Theses and Dissertations

I've always been intrigued by the ways in which the notion of flight has been used to describe the movement of Black people, both literally and figuratively. In many instances, flight performs as a double entendre, embodying multiple meanings: to escape or to transcend. The fluidity of its definition prompts a reflection I’ve been wrestling with as I move through the world: Are Black people in a perpetual state of flight?

In my thesis exhibition, Call for Me When You Get There, I use the precarious state of flight as a means to explore the complicated choreography necessary for navigating …