Digital Commons Network^™

Sacred Screens: Hinduism, Buddhism, Shintoism And Islam In Popular Culture, Arianna A. Poveda

Theses and Dissertations

Popular media content creators have routinely drawn from religious concepts when seeking inspiration for new material. Developers in the West have traditionally relied heavily on Christian themes to supply new ideas. Now, more artists have begun to look towards Hinduism, Buddhism, Islam, and Shinto religions for inspiration when conceiving many of the storylines we find in mainstream entertainment today. This thesis will study key examples of film, video game, literary, and television media to show how these artists weave their religiously inspired themes into their respective platforms. In using the rich stories and traditions to develop more in-depth landscapes and …

Determining Hydraulic Characteristics In Close Proximity Of Hymenocallis Coronaria Within The Flint River Basin, Georgia, Sarah K. Tash

Theses and Dissertations

Emergent macrophytes in river systems occupy a narrow habitat for optimal survival. Each plant species adapts to a set of conditions that meets the physiological requirements to grow and reproduce. The influence of hydraulic characteristics on plant morphology is significant within fluvial systems. Macrophytes must be able to withstand swift flowing water and changes in water surface levels in order to compete with other plant species for limited habitat availability. In addition, emergent macrophytes require water levels to be low enough to allow the reproductive portion of plants to remain above water during certain times of the year. Hymenocallis coronaria …

A Systematic Review Of The Benefits Of Integrating Therapeutic Animals Into Trauma-Focused Treatments For Child And Adolescent Survivors Of Sexual Abuse, Zoe Thorne

Theses and Dissertations

An integrative systematic review with a narrative synthesis was conducted to explore and identify the benefits of integrating a therapy animal into trauma-informed treatment for children and adolescent survivors of sexual abuse. This review detailed various ways therapy animals were incorporated into treatment and when the integration of therapy animals is most and least beneficial. Methods. Eight electronic databases were searched for relevant articles. The search was limited to peer-reviewed articles published in the English-language. Articles published in and out of the United States were included, without a limit on date published, in order to capture any cultural differences and …

A Systematic Review Of Adolescent Girls’ Perception Of Body Image And Self-Esteem Through Participatory Digital Storytelling Groups, Alecia R. Jones

Theses and Dissertations

Adolescent girls face increased pressure to conform to societal standards. As social beings, adolescent girls gravitate to social media as an outlet for peer interaction, community, and validation. Research has found that at the critical age of adolescence, 12-18, girls experience appearance comparison on social media, which can lead to internalizing unrealistic beauty standards and negative self-appraisal. Digital storytelling emerges as a source of encouragement, providing a platform for empowerment, self-expression, community engagement, and a safe space for adolescent girls to share their body image and self-esteem experiences. This Systematic Review sought to synthesize findings of qualitative and mixed-methods studies …

Carotenoids And The Associations With Gut Microbiota Bacterial Populations In Chronic Kidney Disease Hemodialysis Patients, Andrea Kendall

Theses and Dissertations

Background: With increased prevalence and mortality of chronic kidney disease (CKD), treatment by renal replacement therapy using hemodialysis (HD) has increased in parallel. Emerging evidence suggests that gut microbiota play an important role in the progression of CKD; influential dietary factors have not been studied exhaustively to date.

Objective: To explore the relationships between dietary carotenoid intake, the abundance of specific gut microbiota, and symptom-related outcomes in patients with CKD on HD.

Methods: This cross-sectional study investigated the gut microbiota characteristics relative to carotenoid intake in CKD subjects on HD in central Illinois (n = 20). The Block Dialysis …

Illustrating The Fantastic: Cross-Writing Illustrations In British Children’S Literature Of The Golden Age, Stephanie Montalti

Theses and Dissertations

This dissertation argues that British children’s literature of the Golden Age addresses children and adults through their illustrations. It considers why the nineteenth century experienced a proliferation in fantasy and illustration, as well as why Golden Age children’s texts appeal to mixed-age audiences. Through an application of the term “cross-writing,” I argue that the Golden Age of children’s literature did not think of audiences in a binary manner, as some children’s literature scholars tend to assert. Instead, they used the dual mode of textual and visual narration to complicate the boundaries between childhood and adulthood. I also offer an original …

Exploring The Dual Role Of Vegf165 In Bleomycin Induced Lung Injury And Recovery In A Aav Mice Model, Igor Ban

Theses and Dissertations

Pulmonary fibrosis (PF) poses a significant challenge in respiratory medicine due to its complex etiology and progression characterized by excessive lung scarring, leading to compromised pulmonary function. The multifaceted roles of Vascular Endothelial Growth Factor A (VEGF-A) and specifically its isoform VEGF-A165 are critical in this context, given their involvement in angiogenesis, lymphangiogenesis, and tissue repair. The dual nature of VEGF-A165, promoting angiogenesis and potentially exacerbating or mitigating fibrosis, underscores its significance in both the progression and recovery phases of PF. Our work, explores the nuanced functions of VEGF-A165 using AAV1 as a gene delivery vector to overexpress this growth …

A Quality-By-Design Approach For The Development Of Inhalable Dry Powders For Tuberculosis (Tb) Treatment, Suyash M. Patil

Theses and Dissertations

Tuberculosis (TB), caused by Mycobacterium tuberculosis (M.tb), remains a pressing concern globally. The emergence of drug-resistant strains and the need for prolonged treatment regimens continue to complicate disease management. Innovative therapeutic strategies are urgently required to enhance treatment efficacy, improve patient adherence, and minimize adverse effects. Toward this, strategies involving use of drug combinations, reducing dosing frequencies, and targeting TB-infected cells are gaining attention. In my dissertation, we explored the combination therapy involving two FDA-approved anti-TB drugs, Bedaquiline (BDQ) and Pretomanid (PTD). The BDQ-PTD combination reduced minimum inhibitory concentration (MIC), compared to individual drugs and demonstrated additive/synergistic effects at 1:4 …

Role Of Edaravone Nanosuspension In Preterm Labor And Birth Outcomes, Sruthi Sarvepalli

Theses and Dissertations

Annually, preterm birth (PTB) affects fifteen million infants, posing a significant risk of infant mortality and lifelong disability. Among various triggers, it is well-established that infection-associated oxidative stress and inflammation can induce preterm labor. There is no FDA approved medication for the prevention of PTB except tocolytics which provide marginal benefit at a later stage. Scarcity of therapeutic intervention and unmet medical need propelled us in investigating a novel drug molecule. Our current research is focused on investigating the potential of Edaravone (EDA), an FDA-approved antioxidant and anti-inflammatory medication, in delaying preterm labor and improving neonatal outcomes. Our goal is …

Therapeutic Intervention Of Neuroinflammation In Alzheimer Disease By Inhibition Of Classical Complement Pathway Using Anti-C1r Loaded Exosomes, Terjahna Richards

Theses and Dissertations

Alzheimer’s disease (AD) is a neurodegenerative disease associated with memory decline and cognitive impairment. It is a growing global health and socioeconomic concern, affecting more than 50 million people worldwide. Current therapeutics focus solely on symptomatic management instead of preventative or curative strategies. This is mainly a result of the complexity of the pathophysiological mechanism and the poor understanding of the disease progression. Recently, studies have focused on bridging knowledge gaps giving rise to substantial evidence on the vital role of neuroinflammation in the progression of AD. Neuroinflammation has been shown to be a precursor to apparent amyloid plaque accumulation …

Hjp 272, An Endothelin Receptor Antagonist, And Its Role In Cancer Cell Migration And Invasion, Nabeela Fatima Baig

Theses and Dissertations

Endothelins are a family of versatile peptides composed of 21 amino acids with three isoforms: ET-1, ET-2, and ET-3. As the most abundant of the three isoforms, ET-1 is involved in various biological processes, such as regulation of vascular tone, humoral homeostasis, and neural crest development. However, focus is now being directed towards investigating the functions of the Endothelin axis in the progression of different tumor types including ovarian, prostate, breast, lungs etc. HJP 272 is a novel ETAR antagonist and while our group has previously researched its effects on lung inflammation and preterm birth, this study marks the first …

Investigating Ammonium Toxicity In The Performance Of Recirculating Periphytic Algal Wastewater Treatment Systems, Oluchuku Richie Ochonogor

Theses and Dissertations

Freshwater nutrient enrichment from wastewater facilities and other sources can lead to freshwater eutrophication, a threat to global aquatic ecosystems. Mechanical and chemical ways to curb this threat are either too expensive or not sustainable, and thus, not feasible. Compared to mechanical and other methods, sustainable, inexpensive biological methods (for example, algal treatment systems) have therefore been developed for the removal of excess nutrients from wastewater. By design, secondary waste treatment facilities (WWTF) remove organics and solids and lower oxygen demanding substances; however, they may not remove enough nutrients to protect freshwater ecosystems in all cases. While algae-based biological methods …

A Phytochemical Analysis Of Secondary Metabolites In Eupatorium Serotinum, Elise Snow

Theses and Dissertations

Phytochemistry, a subset of Natural Products Chemistry, studies chemically derived products from natural substances. Advances in this field have important applications in medicinal research due to the distinctive and unique properties of natural compounds. All metabolites are produced from the metabolic cycle, which is a pathway that provides energy for the organism. These metabolic compounds vary greatly and are classified based on their function within the organism. Primary metabolites are abundant and contribute to organism growth, development, and maintenance of energy. Secondary metabolites are found in lesser quantity and correlate to natural defense mechanisms. For example, salicylic acid is a …

What Does It Mean To Be A Human In The Age Of Artificial Intelligence?, Campbell R. Eubanks

Theses and Dissertations

Campbell Eubanks’ artwork reflects ideas surrounding the ever-growing complexities of human nature in the context of our growing world. She uses ceramics to investigate human purpose in a digital world by employing artificial intelligence along with her own skills and craft. Her work aims to challenge viewers to contemplate the intricate relationship between humans and artificial intelligence. During her research, Eubanks has looked towards other artists who invite AI into their traditional practices. Sougwen Chung is one example of this. Chung has trained AI robots to learn her style and works alongside them in performances to create collaborative gestural drawings. …

Development Of Leader Voice And Leader Silence Scales: How And Why Leaders Choose To Remain Silent Or Speak Up During Situations Of Workplace Aggression, Katherine L. Dickins

Theses and Dissertations

This study aimed to investigate the factors that drive leaders to speak up or remain silent when witnessing workplace aggression and to develop scales to measure leader voice and leader silence. While research on employee voice and silence exists, leader voice and silence need more theoretical development. I used an exploratory sequential mixed-method design to address these gaps. Subjects: Study one included 26 graduate management students and 35 leaders across multiple industries in the United States who witnessed workplace aggression in their unit. Study 2 included 345 people who supervised others at work. Instruments: Seven open-ended questions asking respondents to …

The Great Race, Willard Bullock

Theses and Dissertations

No abstract provided.

On Writing For Screen And Television, David L. Espey

Theses and Dissertations

No abstract provided.

Voluntary Employee Turnover And The Engagement Perception Of Responsibility, Troy Duerr

Theses and Dissertations

This research project investigates voluntary employee turnover and perceptions of engagement responsibility within organizations. In the aftermath of the COVID-19 pandemic, the US workforce experienced significant pressures. Through qualitative research with semi-structured interviews of 15 professionals, key themes influencing engagement and disengagement were identified. These themes include leadership, recognition, role autonomy, team collaboration, unmet career promises, and poor communication. Participants represented various industries, from Fortune 10 companies to family-owned businesses, and held roles from individual contributors to divisional leaders. This research offers both theoretical advancements and practical solutions, emphasizing the necessity of shared responsibility between employees and organizations in managing …

Trauma Across Culture: A Phenomenological Study Exploring The Historical Effect Of Colonialism, Genocide, And Resilience On Descendants Of Indigenous Peoples In The United States, Monique Lumas-Wright

Theses and Dissertations

Throughout history, massive killings have gravely affected the succession of cultures, and the impact of its traumatization is vast. The centuries-long enslavement of African Americans, the ethnocide of Native American/Alaskan Natives, and the genocide of European Jews represent some of the most horrific catastrophes of human history through the destruction of identity, culture, language, and religion. The destabilization of these distinct groups and the extreme violence experienced by historical injustices have resulted in cultural, mental, emotional, and physical obstructions with profound economic, psychological, and health impacts encompassing both the wounds inflicted by oppression and resilience. The literature review examined the …

The Divine Digital Divide: A Qualitative Analysis Of The Effects Of Implementing Information And Communications Technology In The Black Baptist Worship Service Experience On Attraction And Retention Of Young Adults Post Covid-19, Ladonna Y. Boyd

Theses and Dissertations

The purpose of this study is to examine the effects of using information and communication technology (ICT) in the Black worship experience for recruiting and retaining young adults in relation to church services, engagement (defined in this study as communication, community outreach, social activism and collaboration, and support services), and cultural identity within the community of faith. The relevancy and engagement for emerging generations and the cultural and ancestral ties of the Baptist church will be explored. Data analysis from these findings will be used to identify opportunities for faith and community leaders in relation to young Black adults, defined …

The Ask: A Study Understanding The Motivations Of Major Giving Donors. The Best Strategies And Practices To Achieve Fundraising Successes In Small Charitable Organizations, Courtney Laddusaw

Theses and Dissertations

Most charitable organizations, almost 1 million in the United States, are considered small organizations because they have a budget of less than $50,000 (Statista Research Department, 2023). These numbers show the need for small charitable organizations to develop fundraising protocols, specifically major giving programs (Eisenstein, 2014; Faulk et al., 2021; Stahl, 2013). To create a well-established and sustainable major giving program, charitable organizations must understand the intrinsic and extrinsic motivation of donors (Andreoni, 1990; Breeze, 2023; Chapman et al., 2022; Drollinger, 2018; V. S. Harrison, 2018; Hether et al., 2014; Ko et al., 2011; Kumar & Chakrabarti, 2021; O’Reilly et …

Differences In The Neurological Functioning Of Females And Males During The Human Sexual Response Cycle: A Quantitative Systematic Review, Zachary Larson

Theses and Dissertations

The psychology field recognizes differences between females and males. Yet, there is a lack of research examining neurobiological sex differences, and a sophisticated understanding of neurobiological contributors that explain these sex differences related to sexuality is lacking. An integrative systematic review of the literature examined differences in the neurological functioning between females and males during the human sexual response cycle (SRC). This study investigated sex differences and commonalities in regional neural activation during the four stages of the human SRC (i.e., excitement, plateau, orgasm, and resolution). The main result of this study is that the differences between females and males …

A Phenomenological Study Of Teachers' Perception Of Professional Development Sessions Focused On Artificial Intelligence: Utilizing The Tpack Framework To Address The Professional Development Needs Of Teachers, Xuanyi Chen

Theses and Dissertations

AI-enabled educational tools have great potential for enhancing learning and teaching, yet there is a notable lack of study on AI-focused professional development for K-12 teachers. This phenomenological study employed the TPACK framework to examine teachers' incorporation of AI and engagement in professional development activities. The use of a social constructivism framework explored teachers' views on knowledge, learning, and motivation. Data were collected from 12 K-12 teachers across various districts in a large metropolitan area who attended AI professional development sessions in their own context and from that experience created AI artifacts. Primary data included (a) semistructured interviews, (b) professional …

Storage Facilities And Strategies In The Nile Valley Between The Borderscape Of The First And Third Cataracts (4000 Bc-1000 Bc), Ana Oliveira

Theses and Dissertations

Between the 4th millennium and 1st millennium BC, different communities inhabited the region located within the First to the Third Cataracts. These groups obtained, stored, and distributed foodstuff and commodities in various ways. This paper presents archaeological data from this area and period to shed light into storage strategies and facilities in use during this period on the upper course of the Nile Valley in an attempt to better understand subsistence strategies and economies.

The Effects Of Various Nanoplastics On The Inflammatory Response In Primary Alveolar Epithelial Cells, Eunice J. Pak

Theses and Dissertations

As plastic pollution begins to multiply in the environment and the workplace, gradual degradation of these plastics creates an unseen threat to biological health: nanoplastics. These nanoplastics are common in day-to-day life, and have been found in various internal organs of the human body. The biological and health effects of these nanoplastics are still widely unknown, and only recently has research focused on the impacts of these particles on human health at the cellular level.

In this thesis, poly(methyl methacrylate) and three forms of polystyrene (carboxyl-modified, amine-modified, and neutral surface charge) have been tested on submerged primary C57BL/6 mouse alveolar …

Re-Programming Transcription Factor Function For Neuroscience Research Of Addiction: Investigating The Role Of Zinc Finger Proteins In Driving Cocaine Reinforcement In Mice, Joseph A. Picone

Theses and Dissertations

Administration of addictive drugs like cocaine or morphine initiates aberrant gene transcription within brain reward circuitry neurons, which contributes to the lasting behavioral maladaptations that define addiction. The drug-induced expression and function of key brain transcription factors (TFs) is one major mechanism through which these drugs are able to regulate transcription, and as a consequence, lasting damaging drug-related behaviors including compulsive drug use. The goal of this dissertation is to more fully understand the molecular mechanistic drug-specific actions of TFs within the rodent nucleus accumbens (NAc). The findings from these studies could serve as the basis to identify novel candidate …

Analyzing The Role Of Slc25a32 In Hepatocellular Carcinoma, Mimansha Shah

Theses and Dissertations

Hepatocellular carcinoma (HCC) is the most common primary liver cancer and a leading cause of cancer-related deaths worldwide. Despite advances in understanding its molecular pathogenesis, treatment options for HCC remain limited, highlighting the need for identifying novel therapeutic targets. This study investigates the role of SLC25A32, a mitochondrial transporter gene located on chromosome 8q22.3, in HCC progression. SLC25A32 is involved in the transport of tetrahydrofolate (THF) and flavin adenine dinucleotide (FAD) into mitochondria, playing a crucial role in one-carbon metabolism and redox balance. Using CRISPR/Cas9 technology, we generated potential SLC25A32 knockout clones in the HCC cell line Huh-7. Quantitative PCR …

Shape Inverse Prediction Of Magnetic Field-Actuated Soft Robots By Neural Network Machine Learning, Lineth J. Perez Monsalve

Theses and Dissertations

Soft robotics has drawn tremendous interest in recent years because the compliance and motion of soft robotics enable biocompatibility and versatility for many applications, such as human-machine interaction, wearable and assistive devices, and health monitoring. This study introduces a novel predictive modeling approach using neural networks for shape control of magnetic soft robots. The robots are made of silicone materials embedded with hard magnetic particles, which respond to the external magnetic field provided by a ring-type of permanent magnet. These robots, free from physical connections to external devices, i.e., non-tethered actuation, hold significant potential for applications in healthcare, such as …

Role Of Human Intermediate Form Prl Receptor I-Tail In The Pathogenesis Of Breast Cancer, Shanwei Shen

Theses and Dissertations

Breast cancer continues to be the second most common cancer in women in the United States. The neuroendocrine hormone human prolactin (hPRL) plays an important role in normal mammary gland development and growth, stimulating normal breast tissue proliferation and differentiation. Considerable evidence has shown that hPRL is involved in the malignant transformation of human breast tissue. hPRL enhances viability, invasiveness, and proliferation of breast cancer cells in vitro. Evidence from epidemiologic and genetic studies also implicates role of hPRL in the pathogenesis of breast cancer. Its cognate receptor the human prolactin receptor (hPRLr) is required for the action of hPRL. …

Opioid System's Potential Involvement In Ketamine's Cognitive And Antidepressant-Like Effects In Rats, Fan Zhang

Theses and Dissertations

Depression stands as one of the most pervasive mental health challenges worldwide, including the United States. Conventional antidepressants typically display a delayed onset of therapeutic action (4-8 weeks) and lack efficacy in a substantial portion of patients (over 40% of depressed patients are treatment-resistant). The dissociative anesthetic ketamine, which is a glutamatergic N-methyl-D-aspartate (NMDA) antagonist, has emerged as a promising novel treatment due to its rapid and prolonged antidepressant effects, and it is especially beneficial for treatment-resistant depression. Nevertheless, the precise neurochemical mechanisms underlying ketamine’s antidepressant properties remain elusive, hampering the development of safer and more efficacious treatments. The present …