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You Don't Know Jack: The Dynamics Of Mormon Religious/Ethnic Identity, Michael R. Cope Nov 2009

You Don't Know Jack: The Dynamics Of Mormon Religious/Ethnic Identity, Michael R. Cope

Theses and Dissertations

For much of human existence identity was ascribed based on the group one was born into. In such cultures all aspects of social life were fused into one incontrovertible identity: group identity. However as modern mindsets took root individuals began to shift the foundation of meaning and identity away from the fixed focal point of the group to one of personal preference. In response to this modern trend many groups began to intensify the maintenance of group identity as paramount in the lives of group members. Hammond and Warner (1993) assert that a powerful mechanism for sustaining group identity is …

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Defining The Role Of Citizens In Dialogic Environmental Risk Communication, Holly Lynn Anderson Nov 2009

Defining The Role Of Citizens In Dialogic Environmental Risk Communication, Holly Lynn Anderson

Theses and Dissertations

Risk communication has evolved into an interdisciplinary study involving the work of communication specialists, psychologists, attorneys, and rhetoricians. Of particular interest has been the interaction between government and citizens in environmental risk communication. This interaction has been characterized by citizen outrage in response to dictatorial governmental decision-making. In response, researchers have called for true two-way dialogue between government and the public. This project addressses risk communication during the permitting of hazardous waste management facilities under the Resource Conservation and Recovery Act, identifying the failure to implement two-way dialogue. The project addresses two concerns: (1) the impact of existing legal barriers, …

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Revisiting The Desert Sublime: Billy's Ecotheological Journey In Cormac Mccarthy's The Crossing, Michael J. Riding Nov 2009

Revisiting The Desert Sublime: Billy's Ecotheological Journey In Cormac Mccarthy's The Crossing, Michael J. Riding

Theses and Dissertations

While McCarthy studies have emphasized elements of the sacred in his writing, this thesis adds a new historical perspective and synthesis to reading paradigms of Cormac McCarthy. The Crossing combines the patterns of the ancient pre-Hebraic genre of the desert sublime with the basic formula of the American Western genre to interrogate McCarthy's question of whether in the postmodern moment one can still divest oneself in the desert and find access to the sublime. In an era of an invisible or absent God where post-humanist thought erases the anthropocentric supremacy of human over animal and the earth itself, the one …

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Bpv Entry And Trafficking In Ebtr Cells, Enkhmart Dudleenamjil Nov 2009

Bpv Entry And Trafficking In Ebtr Cells, Enkhmart Dudleenamjil

Theses and Dissertations

Bovine Parvovirus (BPV) belongs to the genus Bocavirus, family Parvoviridae. BPV is the leading etiologic agent among the pathogens that cause primary gastroenteritis of cattle. Many of the intracellular events associated with virus replication are unknown. In this research project, we investigated BPV internalization into the host cell and trafficking in the cytosol. Preliminarily, EBTr cells had abundant clathrin, virus attached to purified clathrin, and EM micrographs revealed virus in endocytic vacuoles. Assays detecting virus infectivity (i.e. viral protein synthesis), virus production (completion of the replication cycle), and quantitative PCR (qPCR) to detect viral transcripts were used to evaluate …

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Optimization Of Functional Mri Methods For Olfactory Interventional Studies At 3t, Vishwadeep Ahluwalia Nov 2009

Optimization Of Functional Mri Methods For Olfactory Interventional Studies At 3t, Vishwadeep Ahluwalia

Theses and Dissertations

Functional MRI technique is vital in investigating the effect of an intervention on cortical activation in normal and patient population. In many such investigations, block stimulation paradigms are still the preferred method of inducing brain activation during functional imaging sessions because of the high BOLD response, ease in implementation and subject compliance especially in patient population. However, effect of an intervention can be validly interpreted only after reproducibility of a detectable BOLD response evoked by the stimulation paradigm is first verified in the absence of the intervention. Detecting a large BOLD response that is also reproducible is a difficult task …

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Predictive Modeling Of Sulfur Flower Buckwheat (Erigonum Umbellatum Torrey) Using Non-Parametric Multiplicative Regression Analysis, David B. Davis Nov 2009

Predictive Modeling Of Sulfur Flower Buckwheat (Erigonum Umbellatum Torrey) Using Non-Parametric Multiplicative Regression Analysis, David B. Davis

Theses and Dissertations

Impacts of humans on ecosystems in western United States have necessitated ecological restoration, which includes the development of native seed that can be used for revegetation efforts. Development of such seed sources are costly and time consuming. This study describes the use of non-parametric multiplicative regression analysis (NPMR) to develop a predictive model for occurrence of sulfur-flower buckwheat (Eriogonum umbellatum Torrey) population seed collection. This perennial forb species is of interest for seed source development in the western United States. Presence and absence data for E. umbellatum was taken from the Utah Division of Wildlife Resources Big Game Range …

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The Moderating Effect Of Adult Attachment Style In The Intergenerational Transmission Of Aggression In Marriage, Faith Rebekah Torres Nov 2009

The Moderating Effect Of Adult Attachment Style In The Intergenerational Transmission Of Aggression In Marriage, Faith Rebekah Torres

Theses and Dissertations

Aggression in the context of marriage and family is a common and serious issue in therapy with couples and families. While it is known that aggression may be transferred across generations, the exact mechanism for how it is transmitted is not fully understood. This study presents adult attachment style as a moderator through which the relationship between family of origin aggression and marital aggression is developed. The present study examined Relationship Evaluation (RELATE) questionnaire data for 332 individuals. Anxious and avoidant attachment were examined as potential moderators between family of origin (FOO) physical aggression or parental hostile conflict style and …

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Quantitative Analysis Of Tobacco Specific Nitrosamine In Human Urine Using Molecularly Imprinted Polymers As A Potential Tool For Cancer Risk Assessment, Kumar Shah Nov 2009

Quantitative Analysis Of Tobacco Specific Nitrosamine In Human Urine Using Molecularly Imprinted Polymers As A Potential Tool For Cancer Risk Assessment, Kumar Shah

Theses and Dissertations

Measuring urinary tobacco specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) and its glucuronide conjugate may provide the best biomarker of tobacco smoke lung carcinogen metabolism. Existence of differences in the extent of NNAL metabolism rates may be potentially related to an individuals’ lung cancer susceptibility. Low concentrations of NNAL in smokers urine (<1 ng/mL) require sensitive and selective methods for analysis. Traditionally, this involves extensive, time-consuming sample preparation that limits throughput and adds to measurement variability. Molecularly imprinted polymers (MIPs) have been developed for the analysis of urinary NNAL by offline cartridge extraction combined with LC-MS/MS. This method when reproduced demonstrated problems with matrix effects. In the first part of this work, investigation of matrix effects and related problems with sensitivity for the published offline extraction method has been conducted. In order to address the need to improve throughput and other analytical figures of merit for the original method, the second part of this work deals with development of a high-throughput online microfluidic method using capillary-columns packed with MIP beads for the analysis of urinary NNAL. The method was validated as per the FDA guidance, and enabled low volume, rapid analysis of urinary NNAL by direct injection on a microfluidic column packed with NNAL specific MIP beads. The method was used for analysis of urinary NNAL and NNAL-Gluc in smokers. Chemometric methods were used with this data to develop a potential cancer-risk-assessment tool based on pattern recognition in the concentrations of these compounds in urine. In the last part, method comparison approaches for the online and the offline sample extraction techniques were investigated. A ‘fixed’ range acceptance criterion based on combined considerations of method precision and accuracy, and the FDA bioanalytical guidance limits on precision and accuracy was proposed. Data simulations studies to evaluate the probabilities of successful transfers using the proposed criteria were performed. Various experimental designs were evaluated and a design comprised of 3 runs with 3 replicates each with an acceptance range of ±20% was found appropriate. The off-line and the on-line sample extraction methods for NNAL analysis were found comparable using the proposed fixed range acceptance criteria.

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The Genetic Epidemiology Of Purging Disorder, Anorexia Nervosa, And Obsessive Compulsive Personality Disorder, Sara Trace Nov 2009

The Genetic Epidemiology Of Purging Disorder, Anorexia Nervosa, And Obsessive Compulsive Personality Disorder, Sara Trace

Theses and Dissertations

Although a variety of factors influence the development of eating disorders, genetic factors contribute notably to their etiology. Understanding genetic factors associated with eating disorders is important, as they can influence how these disorders are recognized, researched, and treated. This dissertation included two studies addressing important questions within the fields of eating disorders and genetics; specifically, Study 1 addressed the prevalence and heritability of purging and purging disorder in a population-based sample of female twins from the United States; and Study 2 investigated the nature of the co-morbidity between anorexia nervosa and obsessive compulsive personality disorder in a population-based sample …

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As Crianças Invisíveis Na Literatura Brasileira: Meninos De Rua, Na Rua E Outras Crianças Em Situação De Risco, Mario Cesar Miranda Melo Nov 2009

As Crianças Invisíveis Na Literatura Brasileira: Meninos De Rua, Na Rua E Outras Crianças Em Situação De Risco, Mario Cesar Miranda Melo

Theses and Dissertations

The United Nations Children's Fund (UNICEF) estimates that tens of millions of homeless children spend a large portion of their lives on the streets, where they are exposed to all forms of abuse and exploitation. In Brazil, approximately eight million children are in this situation. Despite the prolonged and increasing gravity of this situation, there are few and only partial studies showing how these children have been represented in Brazilian literature. Brazilian authors ignored the problem almost completely until the decade of 1960, with the exception of Jorge Amado and a few others. Since then João Antônio, Rubem Fonseca, Clarice …

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Dilute Sulfuric Acid Pretreatment Of Switchgrass In Microwave Reactor For Biofuel Conversion: An Investigation Of Yields, Kinetics,, Oscar Martin Nov 2009

Dilute Sulfuric Acid Pretreatment Of Switchgrass In Microwave Reactor For Biofuel Conversion: An Investigation Of Yields, Kinetics,, Oscar Martin

Theses and Dissertations

Lignocellulosic materials provide a raw material source for biofuel conversion and offer several advantages over fossil fuels- usage of a renewable resource, reduced greenhouse emissions, a decreased dependence on foreign oil, and stimulation of the agricultural sector. However, a primary technological challenge in converting lignocellulosic biomass into fuel is overcoming the recalcitrance of its matrix to enzymatic hydrolysis. To overcome these problems for chemical processing, naturally occurring cellulose biomass must be pretreated before it can be further processed using enzymatic hydrolysis or bioconversion. The goal of this work was to develop a model that predicts the glucose yield (pretreatment and …

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Nonhomologous End-Joining: Tdp1-Mediated Processing, Atm-Mediated Signaling, Amy Hawkins Nov 2009

Nonhomologous End-Joining: Tdp1-Mediated Processing, Atm-Mediated Signaling, Amy Hawkins

Theses and Dissertations

This thesis investigates two separate features of nonhomologous end-joining (NHEJ) DNA repair: end processing, and DNA repair kinase signaling. DNA end processing was investigated in a mouse model of hereditary spinocerebellar ataxia with axonal neuropathy (SCAN1), a congenital neurodegenerative disease. SCAN1 is caused by a homozygous H493R mutation in the active site of tyrosyl-DNA phosphodiesterase (TDP1). To address how the H493R mutation elicits the specific pathologies of SCAN1 and to further elucidate the role of TDP1 in processing DNA end modifications, we generated a Tdp1 knockout mouse and characterized their behavior and specific repair deficiencies in extracts of embryonic fibroblasts …

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Part 1: Screening Of Thirty-One Medicinal Plant Species Against Herpes Simplex Virus, Acetone And Methanol Extracts From The Root Tissue Of Kalanchoe Pinnata Interferes With Hsv Types 1 And 2 Dna Replication And Early And Late Gene Expression Preventing The Spread Of Hsv In Vitro. Part 2: Professional Development Curriculum: Integrating Molecular Biology And Microbiology Into The Existing Secondary Biology Curricula, Mary Ruth Greer Nov 2009

Part 1: Screening Of Thirty-One Medicinal Plant Species Against Herpes Simplex Virus, Acetone And Methanol Extracts From The Root Tissue Of Kalanchoe Pinnata Interferes With Hsv Types 1 And 2 Dna Replication And Early And Late Gene Expression Preventing The Spread Of Hsv In Vitro. Part 2: Professional Development Curriculum: Integrating Molecular Biology And Microbiology Into The Existing Secondary Biology Curricula, Mary Ruth Greer

Theses and Dissertations

PART 1: Thirty-one medicinal plant species from Hawaii, Morocco, and the Sonoran Desert, USA have been shown in past studies to be highly inhibitory to pathogenic bacteria, fungi, and certain cancer cell lines. However, none were tested for antiviral activity. Acetone and methanol extracts from these species were bio-assayed for antiviral activity against herpes simplex virus types 1 and 2 (HSV 1 and HSV 2) and for cytotoxicity to the Vero C1008 cell line. Extracts from these species were tested in vitro for antiviral activity using an immunoperoxidase mini-plaque reduction assay to detect viral structural protein synthesis. Sulforhodamine B and …

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Monkey Pots: Inferring Meaning Through Time And Space From Function, Decoration, And Context, Benjamin Jacob Skousen Nov 2009

Monkey Pots: Inferring Meaning Through Time And Space From Function, Decoration, And Context, Benjamin Jacob Skousen

Theses and Dissertations

In this thesis, I interpret the meaning of “monkey pots,” a pottery vessel found throughout the Maya world. This study looks at three kinds of monkey pots recovered from the Mirador Basin. Carmelita Incised and Zacatal Polychrome monkey pots date to the Late Classic period (AD 680-800) and were manufactured in the Basin; Telchac Composite monkey pots date to the Terminal Classic period (AD 780-830) and were made in the Usumacinta River region. These monkey pots are described, followed by an analysis and comparison of the function, the monkey genus on the vessels, and the contexts from which the vessels …

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Denitration In Colonic Smooth Muscle, Seemab Malick Nov 2009

Denitration In Colonic Smooth Muscle, Seemab Malick

Theses and Dissertations

Tyrosine nitration results in altered function of smooth muscle voltage-gated L-type calcium channel. We explored the possibility that smooth muscle contains denitrase activity to allow functional recovery of the calcium channel without requiring synthesis of new channel proteins. Following peroxynitrite treatment of mouse colonic smooth muscle strips, CaCl2 (1 mM)-induced smooth muscle contraction was significantly reduced by 67% (P ≤ 0.05), which reversed by approximately 86% upon periodic washing within 2 hr period (P ≤ 0.001). The effect of the c-Src kinase inhibitor, PP2, on muscle contraction was also restored after 2 hr post-peroxynitrite treatment consistent with the thesis that …

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Lantern's Diary, Wei Zhong Tan Nov 2009

Lantern's Diary, Wei Zhong Tan

Theses and Dissertations

My MFA project titled, “Lantern's Diary” is a synergy of colors, tactile experiences, and reflections on change. The artwork is based on cultural influences. The physical form of the lantern is a metaphor of culture identity—in Eastern culture, paper has been used in architecture, furniture, clothing, funerals, writing materials, and lanterns. Its function as a material is to fulfill the necessity of daily life and ceremonial rituals. Hence, paper plays an important role in the Eastern society. The color spectrum representing “Change” corresponds with the western system of color organization. The gallery space plays a spatial aesthetic role in …

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Facing Faces, John Luck Nov 2009

Facing Faces, John Luck

Theses and Dissertations

I am a surrealist at heart. I enjoy the creative process of making a visual story that uses unusual imagery. Every work is a reflection of some part of my aesthetic belief: an outgrowth of my individuality. The art I produce is a direct reflection of my personality, beliefs, values, and experiences. I wear my emotions on my sleeve and I have a strong sense of identity. My work exhibits intense colors and strong contrasts. Each has its own underlying subtleties that express the inner depth of the concept. A little attention-deficient and a little bipolar, I am an erratic …

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Design And Development Of A Pvdf Sensor To Monitor Intracranial Pressure (Icp), Vivek Vijaywargi Nov 2009

Design And Development Of A Pvdf Sensor To Monitor Intracranial Pressure (Icp), Vivek Vijaywargi

Theses and Dissertations

Monitoring ICP non-invasively is a challenge. A novel method to measure ICP using actuators and sensors has been proposed where the skull is vibrated at high frequencies and the receiving signal is measured at the surface eyelid. A design of experiments approach is used to develop the sensor part of the ICP monitoring device so that gain can be maximized using factors such as area, thickness, electrode, and applied pressure. Statistical analysis showed that thickness has the biggest effect on overall gain. Numerical analysis confirmed these results. In addition, sensor packaging is optimized to minimize dampening of the signal and …

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Mechanical Behavior And Length Adaptation Of Rabbit Bladder Smooth Muscle, Atheer Almasri Oct 2009

Mechanical Behavior And Length Adaptation Of Rabbit Bladder Smooth Muscle, Atheer Almasri

Theses and Dissertations

Overactive bladder (OAB), involuntary contractions during bladder filling, is a common condition affecting 17% of the adult population worldwide, and in the U.S. ranks ahead of diabetes in a list of the 10 most common chronic disorders (Mullins 2009). Mechanical mechanisms contributing to OAB are not completely understood and because of the unique function and broad volume range of the bladder, there may be mechanical characteristics that distinguish detrusor smooth muscle (DSM) in bladder from other smooth muscles. Recent studies have shown that the length-passive tension curve in DSM exhibits adjustable passive stiffness (APS) characterized by a passive curve that …

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Incarcerated Male Adolescent Suicide In Utah: A Case Study, Kristy Straubhaar Oct 2009

Incarcerated Male Adolescent Suicide In Utah: A Case Study, Kristy Straubhaar

Theses and Dissertations

Adolescent suicide has been described as a major public health problem calling for the aid of researchers willing to better identify factors related to suicide risk. Suicide is the third-leading cause of death for 15 to 24 year olds. Despite the fact incarcerated adolescents act in self-destructive ways, minimal research has focused on suicide behavior among incarcerated adolescents. Existing data indicates that suicide among adolescent males is especially prevalent in the juvenile justice system. Several variables have been identified as risk factors for suicidal behavior, including interpersonal relationship dysfunction, substance abuse, and psychological variables such as depression and dichotomous thinking. …

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The Design And Validation Of A Computational Rigid Body Model Of The Elbow., Edward Spratley Oct 2009

The Design And Validation Of A Computational Rigid Body Model Of The Elbow., Edward Spratley

Theses and Dissertations

The use of computational modeling is an effective and inexpensive way to predict the response of complex systems to various perturbations. However, not until the early 1990s had this technology been used to predict the behavior of physiological systems, specifically the human skeletal system. To that end, a computational model of the human elbow joint was developed using computed topography (CT) scans of cadaveric donor tissue, as well as the commercially available software package SolidWorks™. The kinematic function of the joint model was then defined through 3D reconstructions of the osteoarticular surfaces and various soft-tissue constraints. The model was validated …

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The Regulation Of Alternative Splicing By Oncogenic Signaling Pathways., Jacqueline Shultz Sep 2009

The Regulation Of Alternative Splicing By Oncogenic Signaling Pathways., Jacqueline Shultz

Theses and Dissertations

In the presented study, we demonstrate that the alternative splicing of caspase 9 was dysregulated in a large percentage of NSCLC tumors and cell lines. These findings led to the hypothesis that survival pathways activated by oncogenic mutation regulated this mechanism. Indeed, the oncogenic PI3-Kinase/Akt pathway was demonstrated to regulate the alternative splicing of caspase 9. Further mechanistic studies demonstrate that multiple Akt isoforms can regulate the alternative splicing of caspase 9 in NSCLC. Akt was additionally shown to mediate the exclusion of the exon 3,4,5,6 cassette of caspase 9 via the phospho-state of the RNA trans-factor, SRp30a. Mutagenesis studies …

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Inhibition Of The Calcium Plateau Following In Vitro Status Epilepticus Prevents The Development Of Spontaneous Recurrent Epileptiform Discharges, Nisha Nagarkatti Sep 2009

Inhibition Of The Calcium Plateau Following In Vitro Status Epilepticus Prevents The Development Of Spontaneous Recurrent Epileptiform Discharges, Nisha Nagarkatti

Theses and Dissertations

Status epilepticus (SE) is a major clinical emergency resulting in continuous seizure activity that can cause brain injury and many molecular and pathophysiologic changes leading to neuronal plasticity. The neuronal plasticity following SE-induced brain injury can initiate epileptogenesis and lead to the ultimate expression of acquired epilepsy (AE), characterized clinically by spontaneous, recurrent seizures. Epileptogenesis is the process wherein healthy brain tissue is transformed into hyperexcitable neuronal networks that produce AE. Understanding these alterations induced by brain injury is an important clinical challenge and can lend insight into possible new therapeutic targets to halt the development of AE. Currently there …

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Effect Of Renin Angiotensin System Inhibition On Cardiovascular Sequelae In Elderly Hypertensive Patients With Insulin Resistance, Hala Zreikat Sep 2009

Effect Of Renin Angiotensin System Inhibition On Cardiovascular Sequelae In Elderly Hypertensive Patients With Insulin Resistance, Hala Zreikat

Theses and Dissertations

Background: Insulin resistance may play a pathogenic role in cardiovascular disease (CVD). Resistance to insulin has been associated with obesity, hypertension, and abnormal glucose and lipid metabolism. The constellation of these features among insulin resistant subjects has been called the metabolic syndrome. Prevalence of the metabolic syndrome increases with age and is most common in the elderly. Different criteria have been proposed to define the metabolic syndrome (ATP, WHO, AACE, EGIR). Current management of metabolic syndrome focuses on the specific risk factors that the patient may have without targeting the underlying insulin resistance. Angiotensin Converting Enzyme Inhibitors (ACEI) and Angiotensin …

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Therapeutic Strategies Aimed To Facilitate Axonal Regeneration And Functional Recovery Following Traumatic Spinal Cord Injury, Woon Chow Sep 2009

Therapeutic Strategies Aimed To Facilitate Axonal Regeneration And Functional Recovery Following Traumatic Spinal Cord Injury, Woon Chow

Theses and Dissertations

Traumatic spinal cord injury (SCI) is a physically debilitating, emotionally devastating, financially costly, and life-changing condition that afflicts more than 1,000,000 people in the United States alone. Owing to the characteristic neuropathology and low regenerative capacity of the central nervous system, many victims of SCI are left permanently paralyzed. Though the tissue damage caused by the initial insult almost certainly cannot be reversed, intensive research in recent years to elucidate the cellular and molecular events that follows has provided new grounds for optimism. Accordingly, in this dissertation, we present a number of potential treatment strategies aimed to address some of …

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Precision Navigation Using Pre-Georegistered Map Data, Frederick C. Webber Sep 2009

Precision Navigation Using Pre-Georegistered Map Data, Frederick C. Webber

Theses and Dissertations

Navigation performance in small unmanned aerial vehicles (UAVs) is adversely affected by limitations in current sensor technology for small, lightweight sensors. Because most UAVs are equipped with cameras for mission-related purposes, it is advantageous to utilize the camera to improve the navigation solution. This research improves navigation by matching camera images to a priori georegistered image data and combining this update with existing image-aided navigation technology. The georegistration matching is done by projecting the images into the same plane, extracting features using the techniques Scale Invariant Feature Transform (SIFT) [5] and Speeded-Up Robust Features (SURF) [3]. The features are matched …

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Deriving Optimal Composite Scores: Relating Observational/Longitudinal Data With A Primary Endpoint, Rhonda Ellis Sep 2009

Deriving Optimal Composite Scores: Relating Observational/Longitudinal Data With A Primary Endpoint, Rhonda Ellis

Theses and Dissertations

In numerous clinical/experimental studies, multiple endpoints are measured on each subject. It is often not clear which of these endpoints should be designated as of primary importance. The desirability function approach is a way of combining multiple responses into a single unitless composite score. The response variables may include multiple types of data: binary, ordinal, count, interval data. Each response variable is transformed to a 0 to1 unitless scale with zero representing a completely undesirable response and one representing the ideal value. In desirability function methodology, weights on individual components can be incorporated to allow different levels of importance to …

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Identification And Manipulation Of Resistance To Tomato Spotted Wilt Virus Derived From Solanum Peruvianum, Luis F. Gordillo Jr. Aug 2009

Identification And Manipulation Of Resistance To Tomato Spotted Wilt Virus Derived From Solanum Peruvianum, Luis F. Gordillo Jr.

Theses and Dissertations

The domesticated tomato Solanum lycopersicum (L.), formerly known as Lycopersicon esculentum is a genetically well-studied crop species with high-density linkage and molecular maps based on crosses done between cultivated tomato and its distant related wild species. Wild tomato species harbor a wealth of resistance to many pathogens that have been introgressed into domesticated tomato for genetic control of diseases and pests and for improvement of many agronomic traits. The wild tomato S. peruvianum (L.) is the source of the Sw-5 gene, characterized and mapped to chromosome 9 of the tomato genome and introgressed into elite tomato germplasm, providing resistance to …

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Total Synthesis Of (-)-Acutumine, Fang Li Aug 2009

Total Synthesis Of (-)-Acutumine, Fang Li

Theses and Dissertations

Acutumine is a tetracyclic alkaloid isolated from the Asian vine Menispermum dauricum with selective T-cell cytotoxicity and antiamnestic properties. We have developed a total synthetic route to this congested alkaloid, during which we also found a novel, stereoselective radical-crossover reaction that combines an intramolecular radical conjugate addition with a subsequent enolate hydroxylation. Key features of this synthesis also include a reagent-controlled diastereoselective ketone allylation, an anionic oxy-Cope rearrangement to form a congested quaternary sterocenter, a pyridine-mediated selective ozonolysis, and a Lewis acid promoted Michael-type cyclization.

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An Observational Study Of The Fast Forword Program And Attention Skills Of Students With Learning And Behavioral Difficulties, Eileen A. Mosby Aug 2009

An Observational Study Of The Fast Forword Program And Attention Skills Of Students With Learning And Behavioral Difficulties, Eileen A. Mosby

Theses and Dissertations

This study investigated the effectiveness of the Fast ForWord program (FFW) on attention for students with learning and behavior problems, compared to two other reading programs (Achieve 3000 computerized reading program and a traditional reading program). Improvements in attention skills were observed and compared following a 30-minute, 5 day-a-week schedule. The three programs were implemented within the curriculum in a middle school setting for a 40 day period. The design was a single group study conducted within a single school in the Gloucester County Special Services District. The study participants were 12 seventh through ninth-grade students attending Bankbridge Regional School …

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