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Articles 10021 - 10050 of 15025
Full-Text Articles in Entire DC Network
Rest/Nrsf Is A Master Negative Transcriptional Factor For Neurogenic Program By Maintaining Stem Cell Quiescence In Adult Hippocampal Neurogenesis, Mostafa Nashaat Ahmed Abdelhamid
Rest/Nrsf Is A Master Negative Transcriptional Factor For Neurogenic Program By Maintaining Stem Cell Quiescence In Adult Hippocampal Neurogenesis, Mostafa Nashaat Ahmed Abdelhamid
Theses and Dissertations
Adult neurogenesis occurs in two distinct regions inside the brain, the subventricular zone (SVZ) in the lateral ventricle and the subgranular zone (SGZ) of the dentate gyrus in hippocampus. Neural stem cells (NSCs) are controlled by several intrinsic and extrinsic factors that regulate their proliferation, survival and differentiation in the adult hippocampus. REST/NRSF is considered a master transcription factor that regulates hundreds of neuronal genes essential for neuronal fate decision. In this study, we address the role of REST/NRSF (RE1 silencing transcription factor/Neuro-restrictive silencer factor) in regulating adult neurogenesis in hippocampus.REST/NRSF has biphasic expression in neural stem cells and mature …
Pluralities, Sandra Fernandez
Pluralities, Sandra Fernandez
Theses and Dissertations
This thesis attempts to answer the question - What does it mean to be half/plural Egyptian in Egypt? It focuses on the experiences of individuals with one Egyptian parent and one foreign parent living in Egypt. A secondary goal was to examine how individuals created niches and familiarity for themselves within a socio-cultural context marked by the upholding of rigid social boundaries. Contacts were made through existing social ties and referrals by friends and colleagues. Methodologically I conducted interviews with my interlocutors, after introductory e-mails explaining the project and requesting background information in order to ascertain participants' suitability for the …
Extensions To The Ant-Miner Classification Rule Discovery Algorithm, Khalid Magdy Salama
Extensions To The Ant-Miner Classification Rule Discovery Algorithm, Khalid Magdy Salama
Theses and Dissertations
Ant-Miner is an application of ACO in data mining. It has been introduced by Parpinelli et al. in 2002 as an ant-based algorithm for the discovery of classification rules. Ant-Miner has proved to be a very promising technique for classification rules discovery. Ant-Miner generates a fewer number of rules, fewer terms per each rule and performs competitively in terms of efficiency compared to the C4.5 algorithm (see experimental results in [20]). Hence, it has been a focus area of research and a lot of modification has been done to it in order to increase its quality in terms of classification …
Theurgy In The Medieval Islamic World: Conceptions Of Cosmology In Al-Būnī’S Doctrine Of The Divine Names, John Daniel Martin Iii
Theurgy In The Medieval Islamic World: Conceptions Of Cosmology In Al-Būnī’S Doctrine Of The Divine Names, John Daniel Martin Iii
Theses and Dissertations
The mystical cosmology set forth by Abu-l-ʿAbbās Aḥmad b. ʿAlī b. Yūsuf al-Qurashī al-Būnī (d. 622 / 1225) is of tremendous importance for understanding the development and application of the medieval Islamic occult sciences. In this thesis, we explore the concept and purpose of medieval Islamic theurgy as it is presented by al-Būnī. We will attempt to contextualize it within its complex and nuanced cosmology. His widely distributed and often banned work Shams al-maʿārif presents a challenge to even the most adept reader as it requires advanced understanding in an array of seemingly disparate subjects. This and other of al-Būnī’s …
Paul, The Athenians, And The Breath Of Life: Acts 17:22-31, William Russell Horst
Paul, The Athenians, And The Breath Of Life: Acts 17:22-31, William Russell Horst
Theses and Dissertations
This MA thesis argues that Paul's speech to the Athenians in Acts 17:22-31 includes biblical allusions, as well as concepts and turns of phrase that bear a strong resemblance to those of other Hellenistic Jewish texts, especially those related to the breath of life.
Characterization Of The Expression Of Bdnf And Cgrp And Their Regulatory Pathways In Dorsal Root Ganglion During Cystitis., Sharon Yu
Theses and Dissertations
Interstitial cystitis is a chronic debilitating disease that causes pain and increased frequency of micturition, amongst other symptoms, without any identifiable cause. This disease affects a large number of the population, yet the etiology is still unknown. The present study aimed to characterize BDNF and CGRP—two neuropeptides that have both been proven to play an important role in the transmission of pain as well as in hypersensitivity. The signaling pathways regulating the expression of the two neuropeptides were also examined. Results revealed that BDNF protein expression levels increased in both L1 and L6 DRG following 48 hours post CYP-induced cystitis. …
Chord Conundrum: Examining The Performance Practice Of Polyphonic Figures In J.S. Bach's Solo Violin Works, Emily Vold
Chord Conundrum: Examining The Performance Practice Of Polyphonic Figures In J.S. Bach's Solo Violin Works, Emily Vold
Theses and Dissertations
Interpreting and expressing the musical intentions of a composer in an informed manner requires great dedication and study on the part of a performer. This holds particularly true in the case of music written well before the present age, where direct connections to the thoughts of the composer and even the styles of the era have faded with the passing of time. Violinists today consistently struggle with studying and performing a set of works from the musical period referred to by scholars as the Baroque era (1600-1750), the Sonatas and Partitas for Violin without Bass accompaniment, composed by Johann Sebastian …
A.W.A.R.E. The Assessment Of Autism Spectrum Disorders: A Resource Manual For Parents With Young Children (Ages 0-3 Years), Tiffany Lin
Theses and Dissertations
Autism spectrum disorder is the most common pervasive developmental disorder affecting young children. It results in significant impairments in the acquisition of language, social, and adaptive behaviors. In recent years, participation in intensive early intervention has resulted in significant improvements in communication skills and a more positive prognosis. While the symptoms of autism spectrum disorder, such as impaired social reciprocal interactions, can be identified in the first months of a child's life, parents often encounter difficulty in obtaining appropriate diagnostic assessments. Delays in the assessment process result in a later involvement in critical early intervention and a poorer outcome. To …
Women's Social Networking: Steps That Organize Low-Technology Users With Emergency Needs, Jon O. Gary
Women's Social Networking: Steps That Organize Low-Technology Users With Emergency Needs, Jon O. Gary
Theses and Dissertations
The purpose of the study was for the researcher to develop and have evaluated the content, organization and ease of use of a computer-training program Emergency Response Quick Start book based on Information and Communication Technology environmental designs. This book was most notably based on underutilized women social networking traditions (food recipe/ meal preparation, and service). One research objective guided the development and evaluation of this training program: 1. This study provided an opportunity for a group of urban adults to evaluate, clarify, and test the ease of use of this computer-training program Emergency Response Quick Start book. The 14 …
I Am Here - Are You There? Sense Of Presence And Implications For Virtual World Design, Vicki Suter
I Am Here - Are You There? Sense Of Presence And Implications For Virtual World Design, Vicki Suter
Theses and Dissertations
We use the language of presence and place when we interact online: in our instant text messaging windows we often post: "Are you there?" Research indicates the importance of the sense of presence for computer-supported collaborative virtual learning. To realize the potential of virtual worlds such as Second Life, which may have advantages over conventional text-based environments, we need an understanding of design and the emergence of the sense of presence. A construct was created for the sense of presence, as a collaborative, action-based process (Spagnolli, Varotto, & Mantovani, 2003) with four dimensions (sense of place, social presence, individual agency, …
Lived Experience Of Social Cliques, Shalen Bishop
Lived Experience Of Social Cliques, Shalen Bishop
Theses and Dissertations
The purpose of this study was to determine the extent to which, if at all, students' perceptions of their teachers' care of specific types of cliques was related to those students' high school lived experience for the following four main cliques: popularity, Goths, loners, and others. The goal of this study was to shed light on the history of the preceding variables and the current research related to cliques. Furthermore, it was intended to help guide the researcher in illuminating what has been studied previously regarding social cliques, factors within them, and their effects on student social and academic achievement. …
A Systemic Perspective Of Stress In Emergency Medical Personnel: Emergency Medical Technicians And Firefighters, Rob W. Wennerberg
A Systemic Perspective Of Stress In Emergency Medical Personnel: Emergency Medical Technicians And Firefighters, Rob W. Wennerberg
Theses and Dissertations
Emergency medical personnel (firefighters and ambulance personnel) have higher levels of lifetime PTSD symptoms than the general population. Historically this has been attributed to the number of exposures to traumatic incidents, called the dose effect, but recent literature has suggested that there is a complex web of variables that affect an individual's experience of trauma. Through an interpretive review of the literature this dissertation takes the concepts supported by empirical research and organizes them into an integrated theoretical structure. With ecological psychology at the core, the integration uses Living Systems theory as a structure with which to organize and explore …
Positive Emotions: An Informational Workshop, Rebecca M. Kessler
Positive Emotions: An Informational Workshop, Rebecca M. Kessler
Theses and Dissertations
The purpose of this thesis was to design and evaluate an educational intervention focusing on the role of positive emotions in the workplace. An informational workshop was delivered to the full staff of 18 teachers and 2 directors at Circle of Children Preschool in Santa Monica, California, and emphasized positive emotions and their implications in the workplace in an effort to enhance awareness of emotions and inspire increased levels of positive emotions. A sample set of the staff evaluated the workshop and its effectiveness. The sample was surveyed and interviewed for levels of positive emotions prior to the workshop and, …
Phosphodiesterase-5 Inhibition: A Novel Strategy To Improve Stem Cell Therapy In The Heart, Nicholas Hoke
Phosphodiesterase-5 Inhibition: A Novel Strategy To Improve Stem Cell Therapy In The Heart, Nicholas Hoke
Theses and Dissertations
Several studies have shown cellular replacement therapy as a treatment strategy of myocardial infarction but results have been limited. Therefore, enhancing the therapeutic potential of stem cells injected into ischemic microenvironments by novel preconditioning (PC) techniques is critical for improving cellular therapy. Recent studies have shown that inhibition of phosphodiesterase-5 (PDE-5) is a powerful strategy to precondition the heart and cardiomyocytes against ischemia/reperfusion injury. We therefore tested the hypothesis that inhibition of PDE-5 with sildenafil (Viagra®) or selective knockdown with a silencing vector in adipose derived stem cells (ASCs) would improve their survival after ischemia/reoxygenation in vitro and enhance cardiac …
Hiv Protease Inhibitors Trigger Lipid Metabolism Dysregulation Through Endoplasmic Reticulum Stress And Autophagy, Beth Shoshana Zha
Hiv Protease Inhibitors Trigger Lipid Metabolism Dysregulation Through Endoplasmic Reticulum Stress And Autophagy, Beth Shoshana Zha
Theses and Dissertations
HIV protease inhibitors (PI) are core components of Highly Active Antiretroviral Therapy (HAART). HIV PIs are extremely effective at suppressing viral load, but have been linked to lipodystrophy and dyslipidemia, which are major risk factors for cardiovascular disease. Recent studies indicate that activation of endoplasmic reticulum (ER) stress is an important cellular mechanism underlying HIV PI-induced dysregulation of lipid metabolism. However, the exact role of ER stress in HIV PI-associated lipodystrophy and dyslipidemia remains to be identified. Hepatocytes and adipocytes are important players in regulating lipid metabolism and the inflammatory state. Dysfunction of these two cell types is closely linked …
Synthesis, Screening And Cocrystallization Of Adenosine Based Inhibitors With Methyltransferases, Ermc' And Ksga, Matthew Baker
Synthesis, Screening And Cocrystallization Of Adenosine Based Inhibitors With Methyltransferases, Ermc' And Ksga, Matthew Baker
Theses and Dissertations
Antibiotic resistance threatens to throw mankind back into an era when infectious disease was the predominant cause of death. In an effort to mitigate this danger, we targeted ErmC’ and KsgA. Both methylate N6-adenosine of ribosomal RNA, though each serve different roles in their bacterial host. ErmC’ dimethylates A2058 on 23S rRNA, conferring resistance to MLSB antibiotics (macrolides, lincosamides, streptogramin B). KsgA aids in ribosome assembly, binding inactive 30S until dimethylating A1518/A1519 of 16S rRNA. Like most methyltransferases, ErmC’ and KsgA use cofactor S-adenosylmethionine (SAM) as their methyl source, which binds adjacent to their specific adenosine substrate. ErmC’ inhibitors could …
Biobehavioral Relationships And Health Related Quality Of Life In Persons With End Stage Renal Disease On Hemodialysis, Avis Allen
Theses and Dissertations
The study of immune status and biobehavioral measures is limited in professional nursing. The purpose of the pre-pilot study was to describe levels of cytokines prior to, during, and after dialysis, examine changes in cytokine levels from immediate pre-dialysis to immediate post-dialysis, and to compare cytokine patterns prior to and after dialysis. A within subject descriptive study was conducted as part of a larger pilot study to describe levels of cytokines prior to, during, and after dialysis, examine changes in cytokine levels from immediate pre-dialysis to immediate post-dialysis, and to compare cytokine patterns prior to and after dialysis. Serum cytokine …
Morphometric And Genetic Variation Among Populations Of The Southern Short-Tailed Shrew, Blarina Carolinensis, Located Along The Coastal Plain Of Virginia, Devon Kersten
Theses and Dissertations
The distribution of short-tailed shrews, Blarina carolinensis and B. brevicauda, demonstrates contiguous allopatry in peninsular situations in the Coastal Plain of Virginia, and in other areas. The distribution of these two species is unusual in that they do not exhibit syntopy except within a narrow corridor along the borders of their ranges. Interestingly, along the Coastal Plain of Virginia, B. carolinensis is generally found only at the distal ends of the peninsular areas, existing as local populations that appear to be isolated from each other and from the primary population that exists in south-central Virginia. It is thought that the …
Space Studies For The Ipad : Using Technology To Increase Public Knowledge And Interest In Space Topics, John A. Boucha
Space Studies For The Ipad : Using Technology To Increase Public Knowledge And Interest In Space Topics, John A. Boucha
Theses and Dissertations
No abstract provided.
Listening To The Voices Of Preschool Aged Children Experiencing Homelessness: A Qualitative Approach, Maureen Turner
Listening To The Voices Of Preschool Aged Children Experiencing Homelessness: A Qualitative Approach, Maureen Turner
Theses and Dissertations
This exploratory, three phase qualitative research project gives a voice to preschool aged children experiencing homelessness to identify the significant relationships in their lives. Goals of this research included the exploration of: the central relationships of children experiencing homelessness, who children identify as important people in those relationships, how they describe those relationships, and how those relationships were formed. This research approach utilized a community participatory model in which the children's mothers contributed to the direction of the research project through group interviews. Children were observed for four months and then interviewed while completing three activities. The results suggested three …
Augmented Hands-On: An Evaluation Of The Impact Of Augmented Reality Technology On Informal Science Learning Behavior, Karen J. Elinich
Augmented Hands-On: An Evaluation Of The Impact Of Augmented Reality Technology On Informal Science Learning Behavior, Karen J. Elinich
Theses and Dissertations
This evaluative comparison study was designed to determine the extent to which the application of augmented reality technology increases realization of a hands-on exhibit device's intent and how augmented reality technology might influence family learning behaviors and facilitate the integration of the experiential and interpretive aspects of an informal science learning experience. The study was conducted at The Franklin Institute Science Museum during the summer of 2010. Twenty families interacted with an exhibit device called "Be the Path" in both its traditional hands-on condition and a novel augmented condition. While the sample size was too small to generate statistically significant …
From Isolation To Collaboration: A New Perspective On School Leadership, Bois Paula Du
From Isolation To Collaboration: A New Perspective On School Leadership, Bois Paula Du
Theses and Dissertations
Challenging times demand a greater urgency than usual. Quite unexpectedly, No Child Left Behind has unleashed a powerful catalyst for change in the 21st century. It is within this era of increasing accountability and disparity that greater demands are being placed on school leaders to produce significant and positive student outcomes. The constantly changing educational landscape of today's schools along with the local, state and national legislation that mandates guidelines from which schools must conform necessitates a change in how school leaders are prepared. Therefore, the purpose of this study is to focus on a new perspective of school leadership …
Transformational Leadership And Personal Development: The Impact Of The Youth Citizenship Seminar On Former Participants, Keichea Lashun Reever
Transformational Leadership And Personal Development: The Impact Of The Youth Citizenship Seminar On Former Participants, Keichea Lashun Reever
Theses and Dissertations
The researcher investigated how the Southern California Youth Citizenship Seminar (YCS) impacted the personal development (as outlined by Cashman, 2008) of 142 former participants who responded to an open ended question in a survey administered by Kirnon (2008) and Musick (2008). This qualitative, within site case study utilized detailed analysis and coding of 142 open ended question responses submitted by former Southern California Youth Citizenship Seminar (YCS) participants. The findings of this study revealed that the transformational leadership style utilized by the counselors and guest speakers of the Southern California YCS positively impacted the personal development of 97% of former …
Job Satisfaction Of Managers And Individual Contributors Within Local And Virtual Software Teams, Michael D. Demas
Job Satisfaction Of Managers And Individual Contributors Within Local And Virtual Software Teams, Michael D. Demas
Theses and Dissertations
This study compares the job satisfaction of individual contributors and managers on local (co-located) software teams versus those working on virtual teams. It also examines differences in job satisfaction among workers of differing experience levels. Participants were recruited from two software organizations; one from Company V and one from Company L, a spinoff company formed from Company V's former semiconductor division. The Company L team was a local (co-located) team housed in one building. The Company V team is a distributed virtual software development team and is spread across five cities in California, Oregon, Arizona and Texas. Some members of …
The Implementation Of Corporate Downsizing By Human Resource Managers, A Phenomenological Study, Denise Fazio
The Implementation Of Corporate Downsizing By Human Resource Managers, A Phenomenological Study, Denise Fazio
Theses and Dissertations
This descriptive study explored the phenomenon of corporate downsizing as experienced by Human Resource (HR) managers who were directly involved in its implementation. It was concerned with two primary questions: First, what is the essential structure of the phenomenon of downsizing as experienced by the Human Resource (HR) managers who have been directly involved in its implementation? Second, how does this phenomenon or experience take place? Through the detailed descriptions of four corporate Human Resource managers' downsizing experiences--gathered through in-depth, face-to-face interviews--and my analysis of that data, I explicated the structure (the relationship among the most invariant constituents of the …
Dying And Cultural Meaning: Recommendations For Psychological Support Of Korean Americans, Jung Yi
Dying And Cultural Meaning: Recommendations For Psychological Support Of Korean Americans, Jung Yi
Theses and Dissertations
Death is a natural part of the life cycle that all humankind faces at some point. The American Psychological Association (2001) states that psychologists can make an important clinical contribution to patients who are dying and offer support to their families as they navigate this life event. What is absent from the current discussion is the relevance of culture to issues related to death, dying, and grief, which from the perspective of the researcher is a critical oversight, given the diverse cultures represented in the U.S. and the uniqueness of how many of these cultures conceptualize and memorialize death. This …
Digital Course Materials: A Case Study Of The Apple Ipad In The Academic Environment, Michael H. Bush, Andrea H. Cameron
Digital Course Materials: A Case Study Of The Apple Ipad In The Academic Environment, Michael H. Bush, Andrea H. Cameron
Theses and Dissertations
The newness of the iPad device creates a phenomenon unique and unstudied in the academic environment. By merging the innovations of electronic text, e-reader, and multi-modal functionality, the iPad tablet device can act as an e-reader providing digital course materials as well as a range of other supplementary academic applications. This qualitative research study was designed to explore the how the use of a multi-modal tablet device affects the academic environment. It is the writers' assumption that an increased understanding will aid in the appropriate use of a tablet device to enhance learning. The pilot program in this study included …
View From The Virtual Pocket: Using Virtual Simulation And Video Game Technology To Assess The Situation Awareness And Decision Making Of Ncaa Quarterbacks, Burnie Bristow
Theses and Dissertations
View from the Virtual Pocket is a proof of concept study in which a theoretical proposition about situation awareness in time constrained decision making is wedded to the affordances of a computer based simulation to ascertain if the real world decision making in the pocket of an NCAA quarterback can be modeled successfully for simulation based learning. The researcher used the Situation Awareness Global Assessment Technique (SAGAT) for the purposes of (a) analyzing the situation awareness requirements for expert decision making and (b) to empirically assess the viability of using a computer based football simulator as a SAGAT simulation tool. …
Exploring Individual Self-Awareness As It Relates To Self-Acceptance And The Quality Of Interpersonal Relationships, Camille Fung
Exploring Individual Self-Awareness As It Relates To Self-Acceptance And The Quality Of Interpersonal Relationships, Camille Fung
Theses and Dissertations
Most people spend a significant amount of time at work. Because many workplaces steer away from individual work toward collaboration, the need for high-quality, productive workplace relationships continues to increase. This study examined self-awareness, self-acceptance, and relationship quality to determine the implications for organizations. The purpose of this study was to gain a better understanding of self-awareness and how it relates to an individual's degree of self-acceptance and quality of relationship with others. The research questions were: 1. Do people who show higher degrees of self-awareness report higher degrees of self-acceptance? 2. Do people who show higher degrees of self-awareness …
Transformational Leadership Styles Of Organizational Social Network Leaders As Observed By Fully Employed Pepperdine Business And Leadership Students, Eric Hilary Furlong
Transformational Leadership Styles Of Organizational Social Network Leaders As Observed By Fully Employed Pepperdine Business And Leadership Students, Eric Hilary Furlong
Theses and Dissertations
Of the mechanisms that organizations embrace to find a competitive advantage in post-bureaucratic environments, one of the more common is to allow the emergence of informal networks in which individuals work together regardless of the formal scope of their responsibilities. As these networks emerge, so do leaders within them. To date, there has been almost no research on the leadership behaviors of emergent network leaders. However, that has not stopped many thinkers on the topics of leadership and organizational theory from assigning behaviors to them. Avolio, Bass, and others have assigned transformational leadership to these leaders; and such assignments seem …