Digital Commons Network^™

Controllability And Observability Of Blood Glucose Levels And The Impact Of Covid-19 On Diabetic Patients, Mahra Salem Nasser Abdulla Alblooshi

Theses

Diabetes is a metabolic disorder that is characterized by high blood glucose concentrations resulting from insulin deficiency in case of type 1 or insulin inefficiency in case of type 2. While no cure for diabetes exists, the artificial pancreas is a possible way to manage diabetes, especially for type 1 diabetics. Where an artificial pancreas is a closed-loop control system with an integrated mathematical model. This control system imitates the function of a healthy pancreas. The first part of this thesis is concerned with the control system of an artificial pancreas that is based on Bergman’s minimal model of glucose-insulin …

Characterization And Bioactive Properties Of Young And Mature Soybean And Their Protein Hydrolysates, Amna Khalifa Alnuaimi

Theses

Soybeans are known for their high protein content that could be substituted for animal proteins. The potential bioactive properties of mature soybean (MS) proteins and their hydrolysates have been widely explored. The aim of this study was to investigate and compare various in-vitro bioactive properties (antioxidant, anti-diabetic, anti-obesity, and anti-inflammatory) of young soybean (YS) and MS flour and their protein hydrolysates when subjected to in-vitro simulated gastrointestinal digestion (SGID) and enzymatic hydrolysis, respectively. In the first phase, SGID of YS and MS flour was carried out to mimic the human digestion, while in the second phase, enzymatic hydrolysis of the …

Levels Of Testosterone Esters In Camel Hair, Aysha Khalid Alraeesi

Theses

Doping and steroid use represent a serious threat to animal health and can even lead to their untimely and painful death. However, doping is an acute problem in today's animal racing world, particularly in camel racing. Testosterone and its ten esters (benzoate, valerate, isocaproate, hexahydrobenzoate, decanoate, undecanoate, laurate, enanthate, cypionate, and caproate) are of utmost importance because when they are administered to animals it is difficult to measure them efficiently. The levels of testosterone and its esters in camels and other animals are typically determined using urine and blood tests. The aim of this study was to develop and validate …

Scenario-Based Simulation Of Treatment Processes For Minimization Of Sludge Production From Al-Saad Wastewater Treatment Plant, Omar Gamil Abdelmajeed Hussien

Theses

The biological-activated sludge treatment process is the most widely used approach to treating domestic wastewater. It involves the transformation of soluble and particulate organic matter to gases and large amounts of settleable biomass (produced sludge). This sludge is considered one of the most pressing management challenges since its treatment represents approximately 50 to 60% of the total operational cost of a wastewater treatment plant (WWTP). The traditional management of excess sludge is by disposal in landfills, incineration, or agriculture reuse in the form of fertilizers but due to energy and environmental concerns, many jurisdictions developed strict policies and regulations for …

Transcriptomic Analysis Of The Glycophytic Crop Ipomoea Aquatica Under Salinity Conditions Compared To Its Wild Halophyte Relative Ipomoea Pes-Caprae, Ruwan Saeed Aljneibi Husam Saeed Aljneibi

Theses

This study focuses on the glycophytic crop Ipomoea Aquatica (commonly known as water spinach) and its wild halophytic relative Ipomoea pes-caprae. I. Aquatica is a crop with economic value; however, it is unable to tolerate high levels of salinity. Whereas its relative Ipomoea pes-caprae is able to grow and thrive in the harsh environment of the UAE. The main aim of this study is to analyze the genetic differences underlying the variation in the two plants’ response to salinity and determine the genetic components that can be used to enhance I. Aquatica's tolerance to salinity. Accordingly, the plants were subjected …

Dynamics Biological Efficiency Of Basidiomycetes Fungi In Date Palm Leaf Waste Composting And Suitability As Growing Media, Fatema Saif Alkaabi

Theses

Soil quality and fertility status is grossly poor in arid regions. The problem is compounded due to lack of organic matter in the coarse sandy soil. Therefore, agricultural practices tend to use different organic materials like peat moss, perlite, etc., as organic materials. Despite the role of these growing media in improving the chemical and physical properties of soils, they are non-renewable resources and have high price in the market which make cultivation noneconomical. Hence, renewable resources like biowaste such as date palm leaf waste has been used as alternative source in the experiment to compare with other composting materials …

Fabrication Of Chemically-Functionalized 3dprinted Porous Scaffolds For Biomedical Applications, Eiman Hamed Alblooshi

Theses

Hard tissues, such as bone and teeth, are natural composites of collagen nanofibers that are reinforced by inorganic calcium phosphate Nano crystallites, in the form of nanocomposites. The interlocking between these components in hard tissues explains their unique characteristics. Bone is mainly classified into two major types; compact and cancellous depending on the extent of porosity. Fractures in the compact bone can be treated using bone fixation implants, such as rods, screws, and plates, or can be totally replaced by bone implants if complete substitution is required. Cancellous bone, on the other hand, is highly porous and its substitution with …

Learning With Limited Labeled Data In Biomedical Domain By Disentanglement And Semi-Supervised Learning, Prashnna Kumar Gyawali

Theses

In this dissertation, we are interested in improving the generalization of deep neural networks for biomedical data (e.g., electrocardiogram signal, x-ray images, etc). Although deep neural networks have attained state-of-the-art performance and, thus, deployment across a variety of domains, similar performance in the clinical setting remains challenging due to its ineptness to generalize across unseen data (e.g., new patient cohort).

We address this challenge of generalization in the deep neural network from two perspectives: 1) learning disentangled representations from the deep network, and 2) developing efficient semi-supervised learning (SSL) algorithms using the deep network.

In the former, we are interested …

Using Aerial Photogrammetry And Sexually Dimorphic Measurements To Investigate Seasonal Differences In School Composition Of Delphinus Spp. Off Southern California, Samantha Gm Leander

Theses

Insights into school composition can provide a means to understand basic biology and ecology, including reproductive patterns. They can also be applied to conservation assessments, allowing for better understanding of the potentially differential vulnerability of demographic groups to natural or anthropogenic disturbances that may influence their populations. However, the two subspecies of common dolphins in the waters off California (Delphinus delphis delphis and D. d. bairdii) form large, energetic groups that make characterization of school composition difficult. Remotely controlled drones now offer the opportunity for the study of school composition in Delphinus spp., allowing for precise morphometric measurements …

Developing A Method To Track Marine Snow Aggregation Through Individual Collisions Using Stereoscopic Imaging, Riley Henning

Theses

The aggregation of individual phytoplankton into marine snow allows particles to sink more quickly, thus resulting in the transport of particulate organic carbon from surface waters to the deep ocean. Aggregate formation has previously been measured in experiments indirectly by quantifying how particle size or particle concentration changes over time. Here, I present my thesis in which I applied high-resolution imaging to quantify aggregate formation using two different methodologies.

We conducted experiments to investigate aggregate formation using stereoscopic imaging, tracking individual particles directly in a 3D volume. Phytoplankton cultures were rolled in cylindrical tanks and imaged by two cameras illuminated …

Coastal Watershed Monitoring And Management: Geomorphology, Geochemistry, And Hydrologic Modeling Of Los Peñasquitos Creek, Ca, Ravleen Khalsa-Basra

Theses

Rivers in semi-arid climates are directly influenced by local geographic and hydrologic conditions and impacted by modifications to hydrology via urbanization. Changes can influence erosion, morphology, habitat sustainability, and watershed health. In highly urbanized southern California coastal regions, these rare open spaces provide vital ecosystem services. Los Peñasquitos Creek in San Diego County is one such watershed. Using stream surveying and laboratory methods we quantified channel characteristics, grain size distribution, total metal concentration [M], organic carbon (%OC), and phosphate to longitudinally characterize the creek for improved management. Results identified three distinct reaches in the watershed (upper, middle, lower). Downstream, depth …

Otolith Microchemistry Reveals Low Habitat Connectivity Of California Killifish (Fundulus Parvipinnis) Across A Range Of Spatial Scales, Lisa Robison

Theses

As wetlands face continued fragmentation worldwide, an understanding of habitat connectivity and how fishes that rely on these environments is imperative to conduct effective marine management. Site fidelity and habitat connectivity are vital measures of the interdependence of fish populations living in neighboring marshes (or in regions of a single marsh).

Here, we examine the habitat connectivity, site fidelity, and movement of California killifish (Fundulus parvipinnis) within and among three estuaries in Southern California through otolith microelemental analysis. Assessing the site fidelity of estuarine fishes is important to determine the level of connectivity between spatially distinct populations within …

Towards Robust Gaze Estimation And Classification In Naturalistic Conditions, Rakshit S. Kothari

Theses

Eye movements help us identify when and where we are fixating. The location under fixation is a valuable source of information in decoding a person’s intent or as an input modality for human-computer interaction. However, it can be difficult to maintain fixation under motion unless our eyes compensate for body movement. Humans have evolved compensatory mechanisms using the vestibulo-ocular reflex pathway which ensures stable fixation under motion. The interaction between the vestibular and ocular system has primarily been studied in controlled environments, with comparatively few studies during natural tasks that involve coordinated head and eye movements under unrestrained body motion. …

Diet Of An Important Wetland Resident, The California Killifish, Fundulus Parvipinnis, In A Natural And Created Marsh Habitat In Mission Bay, California, Katie Robinson-Filipp

Theses

The California killifish, Fundulus parvipinnis Girard, is an ecologically important marsh resident. Fundulus parvipinnis is a low-level carnivore, displaying high-site fidelity and occurring in high densities across a range of environmental conditions. Despite the importance of F. parvipinnis to the ecosystem functions of the threatened coastal wetlands of southern California and the Baja California Peninsula, there are critical gaps in our knowledge of this species. In particular, information on their diet and food habits is lacking.

Understanding wetland food web linkages, interactions, and trophic transfer is essential for informing effective habitat management and contributes to our ability to evaluate the …

Analysis Of Nucleosomal Dna Patterns Around Transcription Factor Binding Sites, Sheethal Umesh Nagalakshmi

Theses

Nucleosomes are ~147bp DNA wrapped around the histone octamer which are involved in regulating gene transcription. They have the ability to disassemble depending on the process they are involved in and the nucleosome positioning controls the output of the genome. Therefore, it is important to understand the nucleosome positioning and how its positioning affects the binding of transcription factors (TFs) and gene expression thereby regulating the transcription outcome of the genome. Many studies suggest that TFs and nucleosomes compete with each other for genome accessibility. However, the majority of the studies focus on the nucleosome organization rather than underlying DNA …

The Role Of Software Engineering In Bioinformatics, Brendan Sean Lawlor

Theses

This thesis proposes that by applying state-of-the-art software engineering tools, techniques and frameworks to currently recognised challenges in bioinformatics, improved outcomes can be attained in that field. It begins by decomposing software engineering into two categories, namely process and architecture, and choosing two key challenges in the practice of bioinformatics: reproducibility and scalability. The body of the thesis is an exploration of the intersection between these two software engineering categories and these two bioinformatics challenges. The question is asked: Can best practices in professional software engineering be applied to address key issues in the bioinformatics domain, creating positive outcomes? And …

Predicting, Monitoring And Controlling The Growth Of Listeria In Complex Food Matrices, Laura Mary Nyhan

Theses

Listeria monocytogenes is a foodborne pathogen which is a significant challenge in food production, particularly for ready-to-eat (RTE) products. Incidence of Listeria in RTE foods can be reduced by the application of intelligent combinations of preservative factors or hurdles, while data quantifying the efficacy of hurdle combinations can be exploited and used in the area of predictive microbiology. Traditional culture-based techniques, such as viable plate counts, are commonly used to monitor the growth/survival of microorganisms in foods, however these methods are tedious, time-consuming and due to their destructive nature, are associated with low reproducibility and high variability. Therefore, rapid, non-invasive …

Defining The Potential Of Gene Therapy With Bone Morphogenetic Proteins As A Novel Therapeutic Approach In Parkinson’S Disease, Susan Rebecca Goulding

Theses

Parkinson’s disease is a neurodegenerative disorder, characterised by the progressive degeneration of midbrain dopaminergic neurons, and the intracellular aggregation of the α-synuclein protein in neurons throughout the nervous system. These changes result in the characteristic motor impairments in Parkinson’s disease. Current treatments are solely symptomatic and therefore there is an unmet clinical need to develop new disease-modifying therapies that can alter disease progression. For over 25 years, one proposed experimental therapy has focused on the delivery of proteins called neurotrophic factors to the brain to prevent dopaminergic neuron degeneration. However, to date, clinical trials using the most well-known neurotrophic factors …

Prejudice And Participation - An Investigation Into Challenges Surrounding Access To Early Childhood Care And Education For Children From The Traveller Community In Ireland, Denise Baker

Theses

Travellers are a distinct cultural group, gaining ethnicity in March 2017 but who have traditionally experienced educational disadvantage (Pavee Point, 2018). This study examines the challenges that Traveller children encounter in accessing the Early Childhood Care and Education scheme (DCYA, 2019) in Ireland. Early Childhood Care and Education (ECCE) is widely acknowledged as having a positive impact on children’s holistic development, school success and later outcomes (Boyce et al, 2018; OECD, 2018, NCCA, 2009). This study is underpinned by the bio-ecological systems theory (Bronfenbrenner & Morris, 2007), which considers the child as a construct of their immediate surroundings and the …

Neurovascular Catheter Measurement System Development For Process And Design Effect Evaluation, Cathal Tadhg Merz

Theses

Neurovascular guide catheters are used to treat problems affecting blood vessels within the brain through minimally invasive procedures. Catheters are inserted into the patient via their femoral or brachial arteries and manually navigated to the brain to deliver treatment. This procedure replaces the requirement to cut into the patient’s skull and brain tissue but is limited by reduction of blood vessel lumen diameter and increase in tortuosity of blood vessels deep in the brain. During these procedures, catheters can sometimes fail by kinking or fracturing into two pieces. The rate of failure by fracture of a particular neurovascular catheter device …

Smart Ageing And Renewal Through Entrepreneurial Skills Training, Sarah Davis

Theses

Globally, while the population is ageing, only 3% of older (≥65 years) adults are engaged in entrepreneurship. The Healthy Ageing agenda is responding to the population trends by increasing its focus on elements of active or productive ageing (incorporating older working) with quality of life as a primary outcome. Alignment and exploitation of the synergies between healthy ageing and older entrepreneurial engagement are lacking. Entrepreneurship education is broadening its focus and targeting inclusivity, albeit with as yet little focus on the older population. Older entrepreneurship, while tentatively linked with increased quality of life, has yet to receive direct attention in …

Material Handling System For An Advanced Flexible Manufacturing Environment, Con Cronin

Theses

A Flexible Manufacturing System (FMS) is a method of production that is designed to easily adapt to changes in the type and quantity of the product being manufactured. Machines and computerised systems can be configured to manufacture a variety of parts and to handle the changing levels of production that is required. The aim of this project was to investigate the current manufacturing processes of Kostal Ireland GmbH with the aim of developing a bespoke prototype material handling system to achieve flexible manufacturing. Kostal Ireland GmbH currently do not have the ability to change their manufacturing operations easily when a …

Rf2 Sequestering By Stalled Ribosome During Tnac Synthesis Affects The Expression Of C-Terminal Proline-Containing Nascent Peptides, Mohamed Yousef Ghazal

Theses

The tnaCAB operon in Escherichia coli is regulated via an L-tryptophan dependent ribosome arrest mechanism. TnaC, which codes for a 24-residue leader peptide, has a critical role in regulating the expression of this operon. When inducing concentrations of free L-Trp are reached within the cell, TnaC-ribosome complex is arrested at the tnaC stop codon due to L-Trp binding and interacting with the nascent peptide and translating ribosome. This interaction induces conformational changes in the ribosome active site affecting release factor 2 (RF2)-aided translation termination. Considering that the expression of the tnaCAB operon is among the highest within the cell and …

Crop Salinity Tolerance Induction Using Novel Biostimulants (Saltibio), Elomofe Ikuyinminu

Theses

Salinity is one of the major abiotic stresses affecting crop production, especially in arid and semi-arid areas. Most of the vegetable crops are salt sensitive, growing inadequately in salinised soils due to the accumulation of toxic ions from prolonged, inadequate irrigation programs. A meaningful approach to counteract salinity stress and increase crop yield is the use of protein hydrolysate biostimulants (PHBs). The main objectives of this study were to generate legume-derived PHBs by enzymatic hydrolysis, evaluate their ability to induce salinity stress tolerance in plants, and understand their mode of action. A full compositional and structural analysis of the generated …

Proactive Management Of Acute Oedema Following Hand And Minor Burn Injury, Dale O. Edwick

Theses

Burn injury is a unique trauma. The inflammatory process initiated with burn injury adversely influences all of the Starling equation variables, resulting in increased transvascular fluid filtration, so that oedema as a product of burn injury is more readily formed than in other forms of trauma. Localised wound oedema forms due to minor burn injury, with increasing systemic oedema associated with increased size of burn. It is now recognised that a marked inflammatory and immune response is created with non-severe burn injury, indicating a systemic component with all burns. The effect of oedema formation on the course of the burn …

Laser-Scribed Graphene Electrodes As Inflammatory Biosensors (Laserflame), Pei Shee Tan

Theses

Laser-scribed graphene electrodes (LSGE) are a low cost, portable, flexible and ideal electrochemical platform approach as point of care biosensors. It is anticipated that integrating the detection of immune cell inflammatory cytokines with LSGEs may present a useful diagnostic platform for managing the risk of inflammatory diseases as early detection of inflammatory molecules could significantly improve the treatment and outcome of diseases induced by protracted inflammation, such as cancer, asthma and rheumatoid arthritis. This study proposed LSGE first time novel use in the detection of an inflammatory cytokine released by immune cells (monocyte THP-1 cell line), with high sensitivity and …

Comparison Of The Effects Of Land Use / Land Cover On Water Quality And The Intertidal Marine Macroalgae Communities At The Fluvial Outflows Of The Dingle Peninsula, Cassandra Lew

Theses

The Milltown, Feohanagh, and Owenmore river basins located on the Dingle Peninsula in Ireland were studied to see how variation in land use and land cover (LU/LC) affected water quality and the macroalgal communities at each river’s respective fluvial outflow. Abundance and composition of macroalgae in river and coastal water bodies have been designated as an indicator of water quality according to the Water Framework Directive 2000. The results of this study found that the Feohanagh’s macroalgal community had the highest species richness for most months while the Milltown had the highest Shannon Diversity Index. The Owenmore’s community was consistently …

Investigating The Antioxidant, Immunomodulatory And Anti-Obesogenic Propertiesof Novel Bsg-Derived Extracts And Their Potential As Ingredients In Functional Foods For Older Adults, Suzanne O Brien

Theses

Brewer’s Spent Grain (BSG) represents a substantial waste product of the brewing industry, with 39 million tonnes generated globally every year. To date the primary use of BSG is as animal feed but there is significant interest in identifying alternative uses for this agro-industry by-product. BSG is rich in protein and fibre and is known to contain health-promoting bioactive compounds, thus one application would be in the area of functional foods. People are living longer and as the older adult population continues to increase globally so too is the prevalence of age-related chronic conditions. Diet plays an essential role in …

Is There A Catholic Theology Of Masculinity?, Peter Holmes

Theses

In recent times Catholic theologians have begun to speak of a ‘feminine genius’. Yet relatively little attention given to the unique and positive contribution of masculinity and manhood to relationships, the Church and society. This thesis aims to answer the question, “Is there a corresponding ‘masculine genius?” It attempts to synthesise a specifically Catholic understanding of masculinity from the magisterial teaching of the Catholic Church, to determine a basis for development of the Catholic understanding of masculinity and to propose some lines of development for Catholic theology in this area.

Chapter One will establish the need for and purpose of …

Osseointegration For Amputees: Past, Present And Future: Basic Science, Innovations In Surgical Technique, Implant Design And Rehabilitation Strategies, Munjed Al Muderis

Theses

Loss of a leg or arm is a tremendous disability. Immediate and obvious impairments are decreased mobility or diminished functional capacity. Not quite as obvious are the difficulties associated with activities of daily living, quality of life impairments, sometimes loss of independence or employment, and the mental health issues which often accompany limb loss. The interface between native tissue and the prosthetic limb presents the greatest challenge to amputee rehabilitation. Computer-controlled robotic limbs have been widely available since the 1990s. However, the weight of prosthetic limbs, coupled with the difficulty of where to locate the components, requires substantial loads to …