Digital Commons Network^™

Ultra-Fine Particle Formation Using Principle Of Rapid Expansion Of Supercritical Solutions`, Miraj Minesh Sheth

Theses

There are indications in the chemical and pharmaceutical industries that the reduction in size of a crystalline particle can lead to better performance of the drug compound, particularly for water insoluble drugs, in the final dosage form. Many particle formation techniques have been investigated in recent years by researchers to obtain desired particulate sizes and size distributions. Supercritical fluid technologies have been successfully investigated for particle formation due to its unique gas/liquid properties in the supereritical state. In this report, results of particle formation using the principles of Rapid Expansion of Supercritical Solutions (RESS) have been documented.

In the RESS …

Using Wavelet And Template Analysis To Classify Hand Postures In Unsupervised Daily Activities, Soha Hassan Saleh

Theses

This project's goal was to identify determinants that characterize different types of activities an individual do in daily life, knowing the quality of hand function is essential to plan more effective rehabilitation therapies and treatments for upper limb movement disorders. The first part of the project was Jebsen-Taylor study where healthy individuals and individuals with brain injury performed seven activities classified as precision grasp, cylindrical grasp, and palmar grasp while metacarpal joint angles were measured in real time. The data from those seven activities was used to determine parameters that characterize each type of activity and which might be used …

Long Driving Hours And Health Of Truck Drivers, Stephen J. Benstowe

Theses

In recent time, the health of truck drivers has become a concern for regulatory agencies and safety professionals all over the world. Fatal and non-fatal injury rates for truck drivers are among the highest of all occupations. Truck driving is an important and tedious job. Driving for long hours, drivers are confined to a small space, sit with static lower and upper extremities posture, mentally focus and absorb vibrations.

This thesis provides an in-depth review of the literature related to the problems of long distance truck drivers and commercial motor vehicle operators. The Literature suggests that continuous exposure of truck …

Fracture Healing : The Effects Of Local Insulin Delivery Via Calcium Sulfate And Tricalcium Phosphate, Sarah Elizabeth Buchala

Theses

Previous studies have documented the major role played by insulin in osseous healing. This is the first study to examine local intramedullary insulin delivery to the fracture site and its effect upon the normal fracture healing process. Preceding results show that when administered at the fracture site of the impaired fracture healing model of the diabetic BB Wistar rat, insulin will regulate early cellular proliferation and chondrogenesis and late mineralized tissue, cartilage content and mechanical strength.

In this study, two novel delivery vehicles have been evaluated for sustained insulin release in the normal fracture model of the BB Wistar rat. …

Imaging The Airways, Betsy Skrip

Theses

The IMAGING THE AIRWAYS thesis project is a multidiscipline and multimedia endeavor consisting of two main parts: I. 3D Modeling of a Complete Respiratory Airway for Use in Computational Flow Dynamics Studies of Particle Deposition in the Lungs and II. Creation of an Educational Animation about the Respiratory System for Use in RIT’s Human Visualization Project and CollaboRITorium. Part I involved collaboration with RIT’s Mechanical Engineering Department to construct a 3D model of one complete respiratory pathway, from the oral cavity to the site of gas exchange between the lungs and the blood. The project is a continuation of thesis …

Urine Protein Electrophoresis: Comparison Of Agarose Gel And Capillary Zone Electrophoretic Techniques., Anne-Marie Curtin

Theses

Proteinuria is the excess excretion of protein in the urine and is found in a variety of conditions including renal diseases and neoplastic conditions such as multiple myeloma (MM). The investigation of proteinuria type through the use of electrophoresis is a useful and widely used non-invasive diagnostic tool. The aim of this study was to compare various agarose gel and capillary zone electrophoresis techniques in order to establish a method choice for the separation of protein in routine laboratories. Comparisons were made based on urine monoclonal peak quantification and protein fractions detected. An examination of a capillary zone electrophoresis (CZE) …

Design Of A Multiplex Pcr Assay For The Detection Of Neisseria Gonorrhoeae., Elizabeth J. O'Callaghan

Theses

The incidence of N. gonorrhoeae infections in Ireland has been steadily increasing since 2003. Culture is currently the preferred method of diagnosis, however the sensitivity of culture can be low. In recent years there has been increased interest in non-culture techniques such as polymerase chain reaction (PCR). Many of the PCR assays available have been shown to cross-react with commensal organisms, producing false positive results. This study aimed to improve the detection of N. gonorrhoeae by designing a multiplex PCR assay that used two N. gonorrhoeae genes as targets, thereby providing dual detection and confirmation of a positive result. PCR …

Epidemiology And Drug Resistant Profiles Of Candida Species, In Cork Hospitals., Emma Mccurtin

Theses

Candida causes superficial infections in healthy individuals; however in the immunocompromised host Candida can cause invasive, systemic infections and is a significant cause of morbidity and mortality. This is not due to a more virulent phenotype but to a weakened immune system unable to fight this opportunistic pathogen. The immunocompromised population is ever increasing, due to medical advancements and more aggressive treatments, and hence is the need for epidemiological data of these potentially life threatening infections. The aim of this study was to provide an epidemiological snapshot, of Candida infections from the immunocompromised population in Cork hospitals. Surveillance programmes from …

Sediment Budgets In The Irish Estuarine Environment, Kevin Motherway

Theses

A sediment budget is the quantification of sediment sources and sinks for natural physical systems such as rivers and estuaries.

This thesis has developed estuarine sediment budgets for Cork Harbour, Kinsale Harbour and Youghal Harbour. The thesis includes a literature review of the properties of sediment, river and estuary related sediment transport, sediment management and sediment related legislation and the approaches used to develop a sediment budget for an estuary system.

An extensive study of riverine suspended sediments discharging to the estuaries has been undertaken. Both surface grab samples and depth integrating suspended sediment samples were collected, tested and analysed. …

Container Management And Monitoring Using Sensor Networks, Daniel Rogóz

Theses

The purpose of this project was to develop a functional prototype of a container management and monitoring system, which allows identification and tracking of shipping containers in a port terminal from the moment they enter a port to when they depart for their final destination.

Such system can significantly reduce the labor and time costs associated with organizational mistakes that can occur when containers are being on/off-loaded, moved and stacked in tiers for transfer to the rail or road network. It can be used to streamline the container transport, optimize the order of container on/off-loading and placement, as well as …

Mupirocin Resistance In Staphylococci: An Investigation Of Current Status And Potential Alternative Therapies, Susan O'Shea

Theses

Mupirocin is a topical antibiotic used in hospital infection control practices to control transmission of staphylococci, in particular MRSA, which has become a major problem in Irish hospitals and has a significant impact on patient morbidity and mortality. Overreliance on mupirocin to eradicate MRSA carriage and to prevent infection has led to mupirocin resistance among staphylococcal species. Two distinct types of resistance have developed within strains: low'-level mupirocin resistance (LMR) and high-level mupirocin resistance (HMR).

The aim of this study was to assess the prevalence and types of mupirocin resistance in a large population of clinical staphylococcal isolates including Methicillin …

The Effects Of Writing About Positive Reminiscence On Happiness With Adolescents, Alison M. Senter

Theses

Much research has been done with adults in the field of positive psychology, reminiscence, and journal writing. Previous findings reveal that reminiscing about positive memories enhances one's happiness, well-being, life satisfaction, and self-continuity. The current study sought to expand this to adolescence. A group of 19 male and female ninth graders from a northeastern, suburban high school were assigned to a positive reminiscence or a daily hassles journal writing group. Analyses revealed significant effects on participants' positive affect; journal writing in general and specifically writing only about positive memories both significantly increased participants' ratings of perceived positive affect. However, no …

The Impact Of Storage Container Materials On Iga In Human Breast Milk Stored At Two Different Temperatures, Matthew D. Jenkins

Theses

This study investigated the relationship between the type of material and the concentration of IgA in human milk stored at two temperatures over time. Twelve breastfeeding mothers participated in the study with samples of milk obtained at locations of the participant's preference and transported to the laboratory in a sterile Snappies PP container stored in a cooler filled with ice. The sample was divided up and pipetted into 12 containers. IgA concentrations were determined by enzyme-linked immunosorbent assay at time zero, 9, 24, 48, 72 and 168 hours. Milk IgA concentration decreased in all containers, with the exception of polycarbonate …

The Application Of Lc-Ms Technologies For The Detection Of Triazine Herbicides In Water, Michael Cahill

Theses

The triazine herbicides, including, simazine (6-chloro-N,N’-diethyl-1,3,5-triazine-2,4- diamine), atrazine (2-chloro-4-ethylamino-6-isopropylamino-l,3,5-triazine) and cyanazine were developed as selective weed killers. Their design function is to disrupt the photosynthesis of broad-leafed plants. In the intensive production of grasses (e.g. wheat, cereals, etc.) broad-leafed plants growing in the grass production area are economically costly, competitors with the grasses for nutrients; their removal is facilitated by triazines herbicides and simazine and atrazine are the predominant compounds used. Significant amounts of triazine herbicides are consumed by the agricultural industry each year. However, due to the indiscriminate use of pesticides/herbicides, traces of herbicides have been found in run-off …

Precision Coil Inspection, Karol Murphy

Theses

Boston Scientific produces the Guglielmi Detachable Coil in their Cork based facility. These are used in a surgical procedure to eliminate aneurysms. The first step in the process is to form a coil by wrapping a platinum wire around a mandrel. These coils have outer diameters ranging from 190 pm to 520pm. This is called the primary wind and is inspected to find any defects introduced into the coil from the winding process. These defects may be the result of wire defects in the raw material or possibly poor handling by the operators. These primary winds are processed further to …

Treatment Of Industrial Wastewater Containing Active Pharmaceutical Ingredients With A Membrane Bioreactor, With The Aim Of Reducing Resource Consumption, Pádraig Colm Ó'Maolcatha

Theses

The biodegradation of a selected active pharmaceutical ingredient (API) during wastewater treatment in a membrane bioreactor (MBR) was examined experimentally. A comparison study was conducted by operating a conventional activated sludge (CAS) pilot plant in parallel to the MBR. The MBR was operated under varying conditions of pH (pH6 and pH8), MLSS (6g/L and l0g/L) and SRT (20 days and 30 days) according to a full factorial design of experiments. In the CAS, pH and SRT were altered as above but MLSS was maintained at 3-4g/L. Comparable average API removal results of 95.5% and 95.7% were obtained for the MBR …

Non-Eea (European Economic Area) Entrepreneurs Face No Additional Barriers Than Their Eu Counterparts, When Starting A Business In Ireland., Anthony Garvey

Theses

Do ethnic minority entrepreneurs (EMEs) seeking to start up a business in Ireland operate on a level playing field with their EU counterparts? Or are there unique barriers that EMEs face and if so, what are they and how do we tackle them?

This dissertation examines all of these questions and reveals whether racism or red tape, lack of finance or language skills is suffocating ethnic entrepreneurship more.

It explores the very latest research papers, and reports and combines both qualitative and quantitative data, with a series of semi-structured interviews and a questionnaire aimed squarely at entrepreneurs.

The dissertation discovers …

Art Therapy Student Placement : Challenge And Opportunity?, Niamh Kennedy

Theses

The purpose of this research project is to explore the sector of Student Placement as it forms a significant part of the training programme on the MA in Art Therapy in Cork. The study aims to assess the effectiveness of this part of the educational process for trainees and investigate the impact the Clinical Placement experience has on Student Art Therapists.

By reflecting on the advancement of Art Therapy in our neighbouring isle and exploring the growth of Art Therapy as a profession in the Republic of Ireland, this study aims to chronicle a more recent Irish history of Art …

The Influence Of Health Inquiries On Clinical Governance Systems: A Case Study Of The Douglas Inquiry, Heather Gluyas

Theses

Major failures in patient safety often lead to high profile inquiries set up to establish the facts, and to identify areas of improvement to prevent further failures. In order to learn from inquiries, we need to be able to identify if, and how, the inquiry process influences improvements. Using a case study strategy, this research study examined the perceptions of external stakeholders in regards to the impact or influence of the Douglas Inquiry on KEMH’s clinical governance systems. The research focused on two areas that were highlighted in the final Inquiry report as requiring reform. These systems deal with the …

Research In Aboriginal Contexts: Kimberley Voices, Luke Taaffe

Theses

As a result of the enduring legacy of negative Australian history and culturally inappropriate past research practices, Aboriginal peoples are generally suspicious and mistrusting of research and researchers, particularly non-Indigenous researchers. Poor relations, paternalistic policies, racial discrimination and the inherent unequal power distribution in research relationships has seen many Aboriginal communities exploited, studied as ‘the other’, robbed of intellectual property, sacred artefacts and human remains. The introduction of ethical research guidelines in recent times has since improved contemporary researcher practices; however the lack of grassroots Aboriginal community consultation regarding appropriate, culturally competent research practices led the researcher to ask Aboriginal …

Practical Rationality In The Nicomachean Ethics: An Investigation Into The Use Of Craft Analogies In Relation To Practical Wisdom (Phronesis) And Happiness (Eudaimonia), Tom Vanderveen

Theses

This thesis is an investigation into Aristotle’s use of craft analogies in the Nicomachean Ethics, as instructional to his concept of practical wisdom and happiness. For Aristotle, ethics is predominantly a practice, thus the focus is on practical rationality rather than theory. For this reason, Aristotle’s discussion of ethics lends itself to the use of craft analogy, in that craft is a practice. It is argued that while being a good pedagogical tool, craft analogies fall short, because they do not cover the full gamut of human experience.

Localized Manufacturing And The Future Of Products, Rob Englert

Theses

This paper proposes a new approach to manufacturing products: one that is environmentally friendly, ethically sound and economically viable. Localized manufacturing, and more specifically, Retail Manufacturing (RM) is the concept of retail outlets using advanced additive fabrication processes to print products on demand. RM will streamline many of the steps involved with transporting products to end users. RM will also allow greater end-user participation in the design process, giving consumers more control over product features and aesthetics with a higher level of customization to meet their unique user needs. RM will create and sustain well-paying technical employment opportunities, thus helping …

Rain May Be Heavy At Times: A Collection Of Personal Essays, Natalie Mercer Worrell

Theses

Rain May Be Heavy at Times: A Collection of Personal Essays by Natalie Mercer Worrell is a candid, witty, and emotionally resonant exploration of modern womanhood, family life, and personal growth. Through a series of sharply observed and deeply personal essays, Worrell shares her experiences as a young mother, divorcee, student, and writer, balancing everyday chaos with moments of insight and humor. The collection opens with reflections on the challenges of rekindling a long-dormant writing practice, interrupted by illness, early motherhood, and financial hardship. Worrell charts a path from self-doubt to rediscovery, fueled by a return to education and a …

Enmasking Beckett: The Use Of The Commedia Dell'arte In Waiting For Godot, Shaun Sheley

Theses

In Enmasking Beckett: The Use of the Commedia dell'Arte in Waiting for Godot, Shaun Sheley explores how the traditional Italian theatrical form of Commedia dell'Arte can inform and enhance character development and physical expression in Samuel Beckett’s seminal play Waiting for Godot. Drawing on his experience directing a 2007 university production, Sheley demonstrates how the fixed archetypes and physical vocabulary of Commedia dell'Arte can be applied to Beckett’s characters—Vladimir, Estragon, Pozzo, and Lucky—to support their stylized, non-naturalistic portrayal and Beckett’s own directive for the play to be performed "balletically."

The thesis contextualizes Waiting for Godot within Beckett’s broader …

Guest Satisfaction And Guest Loyalty Study For Hotel Industry, Danijel Carev

Theses

Common perception by practitioners in the hotel industry today that a satisfied guest would become a repeat customer was considered as a major subject of this research. It determined the extent to which satisfaction fostered loyalty. Interviewing guests and demonstrating the expression of visual experience through photography illustrated the guests´ propensity for recommending and returning to the hotel as a repeat customer. Using a provided digital camera, participating guests were asked to photograph whatever caught their eye to illustrate the hotel as being meaningful. In examining factors such as ambience, service, as well as with the guest’s overall satisfaction with …

An Investigation Into The I-Stat Chem8+ System For The Measurement Of Sodium, Potassium, Urea & Creatinine., Gene Ferris

Theses

In the hospital environment Point of Care Testing (POCT) can be an invaluable tool in Emergency departments, Theatres, Intensive Care Units and Paediatric wards by providing rapid test results without the need for transport and laboratory processing. The study design included the collection and duplicate analysis of patient samples firstly using the i-STAT and then on the Architect c8000, a routine laboratory analyser. Statistical analysis was performed in order to determine if there is a statistically significant difference in results between the i-STAT POCT system and current laboratory instrumentation. The parameters analysed were the vital biochemical parameters Sodium (Na), Potassium …

On Imaging Air Pollutants In An Urban Street Canyon Using Tomographic-Doas, Stephen O'Driscoll

Theses

A novel imaging technique based on the combination of differential optical absorption spectroscopy (DOAS) and tomographic reconstruction is presented. This approach, called Tomographic-DOAS, makes it possible to image the spatial distribution of multiple pollutants in an arbitrary region of the atmosphere. Tomographic-DOAS relies on a mathematical model relating measurements of differential optical density to an underlying spatial distribution of pollutants. This model requires the development of an optical system capable of generating multibeam paths or sensing geometries. The optical instrumentation used to construct such sensing geometries is described and a novel scanning beam arrangement that allows a single beam DOAS …

The Application Of Social Marketing In Reducing Road Traffic Accidents Among Young Male Drivers - An Investigation Using Physical Fear Threat Appeals., Brian Harman

Theses

In 2004, the Irish government rolled out its new two year road safety strategy which aimed to reduce road deaths in the Republic of Ireland to no more than 300 road fatalities by 2006. The strategy failed to reach its target. There were 368 road fatalities on Irish roads in 2006. The effects of the penalty points system, which was introduced in 2003, is considered responsible for reducing Irish road fatality figures to their lowest level since 1964 (335 deaths). However the beneficial effects of the penalty points system have proved transitory and road deaths have risen in recent years. …

Detection And Molecular Epidemiological Analysis Of Acute Gastroenteritis Viruses In The South Of Ireland, Grainne Lennon

Theses

Rotavirus infections are considered to be the most common cause of severe gastroenteritis in children under the age of 5 years, and are responsible for up to 611,000 deaths annually, mainly in developing countries. From 1997 to 1999, 16 hospital laboratories in the Republic of Ireland reported to detection of 4,643 cases of rotaviral disease, while in 2004 and 2005 and increase of 1,600 and 2,251 rotavirus cases were reported. These rotavirus cases have a significant impact on the healthcare system with the minimum cost per case being €728.40. A large percentage of the infections were reported in neonates, suggesting …

Optimization In Multi-Agent Systems : Structures And Procedures, Ingo Stengel

Theses

The main advantage for the use of agent technology is in the capacity of agents to represent the interests of individual entities and to act autonomously on their behalf. In multi-agent systems this involves communication, coordination and negotiation.

The focus of this dissertation is to find ways to optimize multi-agent systems at different levels by taking into consideration their structure and the procedures used. As optimization depends to a large extent on the problem to be solved, group forming scenarios, in which self-interested agents compete to form and join groups, have been selected here for consideration. Optimization issues are discussed …