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Does Cancer Treatment Affect Connections In The Brain?
Does Cancer Treatment Affect Connections In The Brain?
Saudi Medical Journal
No abstract provided.
Do Disasters Delay Early Cancer Diagnoses?
Do Disasters Delay Early Cancer Diagnoses?
Saudi Medical Journal
No abstract provided.
Who Launches First-Ever Guidelines On Meningitis Diagnosis, Treatment And Care
Who Launches First-Ever Guidelines On Meningitis Diagnosis, Treatment And Care
Saudi Medical Journal
No abstract provided.
An Exploration Of Serum 25-Hydroxyvitamin D Levels After Unstable Femoral Intertrochanteric Fractures In Community-Dwelling Elderly, Hakan Zora, Gökhan Bayrak
An Exploration Of Serum 25-Hydroxyvitamin D Levels After Unstable Femoral Intertrochanteric Fractures In Community-Dwelling Elderly, Hakan Zora, Gökhan Bayrak
Saudi Medical Journal
ABSTRACT Objectives: Inadequate vitamin D is related to increased fall risk, which leads to hip fractures among the elderly. Therefore, this study aimed to explore vitamin D levels and the variables potentially influencing the total hospitalization time of community-dwelling elderly patients with unstable femoral intertrochanteric fractures. Methods: Between 2020-2024, 75 elderly patients treated with total hip replacement (THR) were retrospectively analyzed. Patients were divided into the deficient (<20 ng/mL, n=46), insufficient (20 to 29.99 ng/mL, n=16), and normal (≥30 ng/mL, n=13) serum 25-hydroxyvitamin D (25(OH)D) groups. Presence of delirium status, postoperative intensive care entrance, number of chronic diseases, preoperative waiting, and total hospitalization time after THR were recorded. Results: The cohorts’ mean serum 25(OH)D level was 20.11ng/mL. The deficient, insufficient, and normal serum 25(OH)D level groups displayed no significant difference in the postoperative intensive care entrance ( p =0.547) and the presence of delirium ( p =0.947). The multiple linear regression model indicated that elderly patients’ total hospitalization increases with the coefficients as the preoperative waiting time (β=0.466, p =0.001) and the number of chronic diseases (β=0.263, p =0.011) increase. Serum 25(OH)D level did not impact patients’ total hospitalization time (β=-0.072, p =0.474). Conclusion: This study indicated that community-dwelling elderly patients with unstable femoral intertrochanteric fractures had significantly decreased serum 25(OH)D levels. Reducing preoperative waiting time and monitoring and addressing chronic diseases may decrease total hospitalization. Efforts should focus on achieving and maintaining adequate vitamin D levels through supplementation post-hospitalization.
Validation Of Digirop- Birth And Digirop- Screen For The Discovery Of Retinopathy Of Prematurity Requiring Treatment In Preterm Births In Saudi Arabia, Huda K. Ahmedhussain, Lina H. Raffa, Amal M. Alosaimif, Sarah K. Alessa, Suzan Y. Alharbi, Hashem Almarzouki, Mansour A. Alqurashi
Validation Of Digirop- Birth And Digirop- Screen For The Discovery Of Retinopathy Of Prematurity Requiring Treatment In Preterm Births In Saudi Arabia, Huda K. Ahmedhussain, Lina H. Raffa, Amal M. Alosaimif, Sarah K. Alessa, Suzan Y. Alharbi, Hashem Almarzouki, Mansour A. Alqurashi
Saudi Medical Journal
ABSTRACT Objectives: To validate 2 DIGIROP prediction models for retinopathy of prematurity (ROP) type 1 and compare them to other weight-based algorithms in a premature Saudi Arabian infant cohort. Methods: Preterm infants of 24-30 weeks’ gestational age (GA) or body weight (BW) of ≤1500g who were admitted to the neonatal units of 2 Jeddah tertiary centers between January 2015 and September 2021 were included (N=363). The DIGIROP-Birth employed the birth GA, gender, birth weight, and age at ROP onset as predictors. The area under the receiver operating characteristic curve (AUC) with 95% confidence interval, specificity, and sensitivity were projected. The …
Do Lifetime Body Weight Patterns Affect Kidney Cancer Risk?
Do Lifetime Body Weight Patterns Affect Kidney Cancer Risk?
Saudi Medical Journal
No abstract provided.
Harnessing Artificial Intelligence For Infection Control And Prevention In Hospitals: A Comprehensive Review Of Current Applications, Challenges, And Future Directions, Fahad A. Alhusain
Harnessing Artificial Intelligence For Infection Control And Prevention In Hospitals: A Comprehensive Review Of Current Applications, Challenges, And Future Directions, Fahad A. Alhusain
Saudi Medical Journal
ABSTRACT Hospital-acquired infections (HAIs) significantly burden global healthcare systems, exacerbated by antibiotic-resistant bacteria. Traditional infection control measures often lack consistency due to variable human compliance. This comprehensive review aims to explore the role of artificial intelligence (AI) in enhancing infection control and prevention in hospitals. A systematic literature search was conducted using databases such as PubMed, Scopus, and Web of Science up to October 2024, focusing on studies applying AI to infection control. The review synthesizes current applications of AI, including predictive analytics for early detection, automated surveillance systems, personalized medicine approaches, decision support systems, and patient engagement tools. Findings …
Advancing Genetic Counselling In Southern Africa: Unveiling Opportunities For Inclusive Healthcare And Genomic Education For Angola, Maria Chimpolo, Shahida Moosa, Nasser Calumbuana, Elka Kay, Hashim Halim-Fikri, Dhavendra Kumar, Bin Alwi Zilfalil
Advancing Genetic Counselling In Southern Africa: Unveiling Opportunities For Inclusive Healthcare And Genomic Education For Angola, Maria Chimpolo, Shahida Moosa, Nasser Calumbuana, Elka Kay, Hashim Halim-Fikri, Dhavendra Kumar, Bin Alwi Zilfalil
Saudi Medical Journal
ABSTRACT Objectives: To critically evaluate the current status quo of genetic counseling in Southern Africa by uncovering grey areas in their integration within national healthcare systems. It pinpoints the need for improved genetic education and healthcare inclusivity to advance genomic medicine and precision healthcare for underserved populations by analyzing policy frameworks, infrastructure, education, and initiatives. Methods: A systematic review following PRISMA guidelines examined studies on genetic testing in Southern Africa from 2008 to 2023. Searches in databases such as PubMed, Scopus, and Web of Science employed keywords and MeSH terms. A 2-tiered screening process selected studies, and extracted data were …
Patterns Of Antibiotic Resistance In Uropathogens Isolated From Pediatric Patients: A Multicenter Study, Zeyad A. Almatroudi, Abdullah M. Almazrou, Abdullah H. Aljomoai, Zaid M. Alsulami, Abdulaziz M. Alotaibi, Abdulmohsen A. Almutairi, Aiman El-Saed, Faisal A. Alsehli, Majid M. Alshamrani
Patterns Of Antibiotic Resistance In Uropathogens Isolated From Pediatric Patients: A Multicenter Study, Zeyad A. Almatroudi, Abdullah M. Almazrou, Abdullah H. Aljomoai, Zaid M. Alsulami, Abdulaziz M. Alotaibi, Abdulmohsen A. Almutairi, Aiman El-Saed, Faisal A. Alsehli, Majid M. Alshamrani
Saudi Medical Journal
ABSTRACT Objectives: To evaluate the antibiotic resistance patterns in common uropathogens isolated from pediatric patients. Methods: This was a retrospective chart review on the uropathogens causing first-time, community-acquired, symptomatic urinary tract infection (UTI). The data for this study was collected from one tertiary care hospital and 4 primary care centers in Riyadh, Saudi Arabia, with data spanning from 2017-2022. Diagnosis of UTIs was in line with the guidelines of the American Academy of Pediatrics. Results: Isolates were gathered from 610 patients, 101 (16.6%) of whom were male and 509 (83.4%) were female. The 3 most common species isolated were Escherichia …
Researchers Optimize A Method Using Seawater That Produces Mineral Deposits While Trapping Carbon Dioxide
Saudi Medical Journal
No abstract provided.
Who Brings Countries Together To Test Collective Pandemic Response
Who Brings Countries Together To Test Collective Pandemic Response
Saudi Medical Journal
No abstract provided.
In This Issuesystematic Revieworiginal Articles
In This Issuesystematic Revieworiginal Articles
Saudi Medical Journal
No abstract provided.
Normative Pulse Oximetry Values In Healthy Children: A Cross-Sectional Study From Jeddah, Saudi Arabia, Turki S. Alahmadi, Mohammed A. Alsubaie, Abdullah Z. Alsuheili, Anas S. Alyazidi, Israa A. Habis, Taif K. Alotibi, Areen Y. Ibrahim, Saddiq B. Habiballah, Matter A. Alsulami
Normative Pulse Oximetry Values In Healthy Children: A Cross-Sectional Study From Jeddah, Saudi Arabia, Turki S. Alahmadi, Mohammed A. Alsubaie, Abdullah Z. Alsuheili, Anas S. Alyazidi, Israa A. Habis, Taif K. Alotibi, Areen Y. Ibrahim, Saddiq B. Habiballah, Matter A. Alsulami
Saudi Medical Journal
ABSTRACT Objectives: To establish reference values for peripheral oxygen saturation levels in children using pulse oximetry. Pulse oximetry to assess peripheral oxygen saturation is widely used in pediatric care as part of vital signs monitoring. Although readings between 95% and 100% are often considered normal in clinical practice, recent studies suggest that the normal peripheral oxygen saturation range should be between 97% and 100%. Methods: This cross-sectional study included children aged ≤18 years attending pediatric clinics and not having respiratory distress or acute illness during their visit. Vital signs and anthropometric measurements were recorded. Oxygen saturation and pulse rate were …
Comparative Study Of Pregnancy Risks In Different Maternal Age Groups, Amala Sunder, Yusuf Khaled Hadi, Noor Ammar Alkhuzaei, Nayla Jamal Bushaqer, Basma Darwish, Nawal Dayoub
Comparative Study Of Pregnancy Risks In Different Maternal Age Groups, Amala Sunder, Yusuf Khaled Hadi, Noor Ammar Alkhuzaei, Nayla Jamal Bushaqer, Basma Darwish, Nawal Dayoub
Saudi Medical Journal
ABSTRACT Objectives: To evaluate and compare pregnancy complications associated with varying maternal age groups. Methods: A retrospective analysis of singleton pregnancy outcomes at Bahrain Defense Force Hospital from January to December 2022. The study population was divided into 4 age groups: <25 years, 25-29 years, 30-34 years, and ≥35 years. Data on demographics, maternal and fetal characteristics were collected, and statistical significance was set at p <0.05. Univariate logistic regression was performed to analyze maternal and neonatal outcomes, adjusting for maternal factors. Results: The study included 2,972 women aged 17-55. Significant associations were found between maternal age and outcomes. Body mass index (BMI) was significantly linked to age ( p <0.01), with younger women having lower BMI. Gestational diabetes mellitus (GDM) was more common in women ≥35 years (11.5%) vs. those <25 years (6.6%, p =0.027). Intrauterine growth restriction (IUGR) was more prevalent in the <25 years age group ( p =0.041).Logistic regression showed women 30-34 years had a lower risk of GDM compared to 25-29 years (odds ratio [OR]: 0.544, CI: 0.365-0.811), and women <25 years had a higher risk of preterm delivery (OR: 1.365, CI: 1.015-1.837). Conclusion: Maternal age is an independent risk factor for various adverse outcomes. Younger women (<25) are at higher risk for preterm delivery and IUGR, while older women (≥35) have higher rates of GDM.
Gender Differences In Patient-Reported Outcomes And Cardiac Symptoms In Patients With Acute Coronary Syndrome In Riyadh, Saudi Arabia, Sultan Alosaimi, Abdullah Alqarni, Turki Alkalifah, Mansor Aldaijy, Nawaf Alghamdi, Abdulltaif Altalhah, Ambreen Kazi, Waleed Alharbi
Gender Differences In Patient-Reported Outcomes And Cardiac Symptoms In Patients With Acute Coronary Syndrome In Riyadh, Saudi Arabia, Sultan Alosaimi, Abdullah Alqarni, Turki Alkalifah, Mansor Aldaijy, Nawaf Alghamdi, Abdulltaif Altalhah, Ambreen Kazi, Waleed Alharbi
Saudi Medical Journal
ABSTRACT Objectives: To measure the gender differences in patient-reported outcomes and cardiac symptoms in patients with acute coronary syndrome (ACS) at King Khalid University Hospital in Riyadh, Saudi Arabia. Methods: A cross-sectional study was conducted on 240 randomly selected ACS patients aged ≥18 years. Data were collected using validated questionnaires, including Patient-reported outcomes measures, the Rose Dyspnea Scale, Patient Health Questionnaire, and Seattle Angina Questionnaire. Multiple linear regression analysis was conducted to identify factors associated with quality of life (QoL). Results: The study included 60% males and 40% females. Females reported significantly lower global physical health scores (11.62 [±2.49] versus …
Emergency Patients With Mild Elevations Of Serum Lipase And Acute Pancreatitis, Saqer M. Althunayyan, Abdulmajed K. Alali, Laila K. Alanazi, Salma S. Alkhalifah, Emad M. Mashdali, Mohammed A. Malabarey, Saad A. Alasiri, Abdulmajeed M. Mobrad
Emergency Patients With Mild Elevations Of Serum Lipase And Acute Pancreatitis, Saqer M. Althunayyan, Abdulmajed K. Alali, Laila K. Alanazi, Salma S. Alkhalifah, Emad M. Mashdali, Mohammed A. Malabarey, Saad A. Alasiri, Abdulmajeed M. Mobrad
Saudi Medical Journal
ABSTRACT Objectives: To estimate the incidence of AP and determine potential predictors and the outcomes. Elevated lipase level of <3 times the upper limit of normal (ULN) cause diagnostic confusion for acute pancreatitis (AP). Methods: A multicenter, 6-year retrospective study enrolled adult patients who were detected with lipase level of 80–240 IU/L in the Emergency Department (ED). The Revised Atlanta Classification was used to identify AP within 72 hour (hr) from the first ED visit. Results: Of 1082 patients, 68 (6.3%) had AP, 393 (36.3%) were hospitalized, 64 (6%) required intensive care unit admission, and 2 (0.2%) died. Most AP cases were confirmed using computed tomography CT; 47 (69.1%), followed by repeated lipase level 15 (22.1%) and ultrasound 14 (20.6%). Alcohol exhibited the highest adjusted odds ratio of predicting AP (3.9–45.6), followed by white blood cell count (1.340–6.222), male gender (1.451–4.308), and higher lipase level (1.009–1.02). Among AP cases, 11.8% required ICU admission and 1 died within 72 hr. Chronic heart disease, obesity, fever, and tachycardia were associated with these critical outcomes. Conclusion: Among the study sample, 6.3% were diagnosed with AP. Most of the cases confirmed by CT and alcohol was the strongest risk factor in predicting AP. A prediction score system to stratify AP risk when lipase is <3 ULN is warranted.
Risk Of Malignancy In Thyroid Nodules Bethesda Iii Sub Classification Into Nuclear Atypia And Architectural Atypia. A Retrospective Study
Saudi Medical Journal
ABSTRACT Objectives: To identify the risk of malignancy in the Bethesda III category based on histopathological subclassification. Methods: We retrospectively analyzed 193 patients with Bethesda III thyroid nodules who underwent surgical resection. The primary outcome was the malignancy risk associated with each histopathological sub-classification. Results: Of 193 patients, final histopathology revealed malignant nodules in 96 (49.7%). The malignancy rates varied among the Bethesda III subcategories, with Hürthle cell atypia of undetermined significance demonstrating the highest rate (55.6%), followed by cytological atypia (55.4%), architectural atypia (50.6%), and combined cytological and architectural atypia (33.3%). However, no significant difference in malignancy rates was …
Rising Ranking Of Saudi Universities In Global Science
Rising Ranking Of Saudi Universities In Global Science
Saudi Medical Journal
No abstract provided.
Many Pregnancy-Related Complications Going Undetected And Untreated – Who
Many Pregnancy-Related Complications Going Undetected And Untreated – Who
Saudi Medical Journal
No abstract provided.
Prevalence And Impact Of Endocrinopathies On Growth In Pediatric Down Syndrome Patients: A Retrospective Analysis, Lena H. Alfaraj, Zainab A. Al-Askari, Ahmed S. Alkhalifah
Prevalence And Impact Of Endocrinopathies On Growth In Pediatric Down Syndrome Patients: A Retrospective Analysis, Lena H. Alfaraj, Zainab A. Al-Askari, Ahmed S. Alkhalifah
Saudi Medical Journal
ABSTRACT Objectives: To assess the prevalence of endocrinopathies and their impact on growth among pediatric patients with Down syndrome (DS) in the Eastern Region of Saudi Arabia. Methods: This study utilized a retrospective cross-sectional design and was conducted at the Qatif Central Hospital between January 2015 and December 2022. Data from 358 pediatric patients with DS (aged 0–14 years), including clinical, anthropometric, and laboratory findings, were analyzed. The prevalence rates of endocrinopathies, their association with comorbidities, and their impact on growth metrics were evaluated using statistical methods. Results: Hypothyroidism was the most prevalent endocrinopathy (18.9%), followed by vitamin D deficiency …
Serum And Cord Blood Neutrophil Gelatinase Associated Lipocalin Levels In Pregnant Women With Gestational Diabetes Mellitus And Its Association With Tumor Necrosis Factor-Alpha: A Cross-Sectional Study From Tripura, India, Bidhan Goswami, Sumit S. Das, Partha S. Pal, Partha Saha, Shauli Sengupta, Manti Debnath
Serum And Cord Blood Neutrophil Gelatinase Associated Lipocalin Levels In Pregnant Women With Gestational Diabetes Mellitus And Its Association With Tumor Necrosis Factor-Alpha: A Cross-Sectional Study From Tripura, India, Bidhan Goswami, Sumit S. Das, Partha S. Pal, Partha Saha, Shauli Sengupta, Manti Debnath
Saudi Medical Journal
ABSTRACT Objectives: To examine the significance of neutrophil gelatinase-associated lipocalin (NGAL) and tumor necrosis factor-alpha (TNF-α) in women with gestational diabetes mellitus (GDM) and their correlation with insulin resistance and metabolic markers. Methods: Blood samples from maternal and cord sources were obtained from 289 pregnant women, divided into GDM, prediabetic, and normal pregnancy groups. Serum levels of NGAL, TNF-α, insulin, fasting blood sugar (FBS), homeostasis model assessment-estimated insulin resistance (HOMA-IR), triglycerides, cholesterol, and so on were measured. Statistical analyses, including the Kruskal-Wallis test and Mann-Whitney U test, were used to compare NGAL levels across patient groups and ethnicities. Results: Women …
A Bibliometric Analysis Of Disability Research In Saudi Arabia: Evolving Trends, Thematic Mapping, And Gaps, Mahmoud Kandeel, Mohamed A. Morsy, Sameer Alhojaily
A Bibliometric Analysis Of Disability Research In Saudi Arabia: Evolving Trends, Thematic Mapping, And Gaps, Mahmoud Kandeel, Mohamed A. Morsy, Sameer Alhojaily
Saudi Medical Journal
ABSTRACT Objectives: To identify key trends and influential authors and institutions, provide thematic mapping, and determine recent evolutions and gaps in the disability research in Saudi Arabia. Methods: The study started in June 2024 and the data was analyzed during July 2024 in Al-Ahsa, Saudi Arabia. The analysis employed bibliometric techniques such as bibliometric coupling, and thematic mapping using VOSviewer and RStudio with the Bibliometrix package. Results: The bibliometric analysis identified a total of 3080 publications and showed that the annual growth rate in the number of publications was 13.5%. Emerging themes included intellectual disabilities, quality of life, rehabilitation, and …
Prevalence Of Immunoglobulin E Sensitization To Various Inhaled Allergens Among The Residents Of The Northern United Arab Emirates: Automated Evaluation Of A Membrane-Based Test System, Israa O. Yousif, Nazeerullah Rahamathullah, Nelofar S. Khan, Mohammad Mesbahuzzaman, Mohammed Abdulrazzaq, Fawzia A. Alobeidli, Praveen K. Kandakurti
Prevalence Of Immunoglobulin E Sensitization To Various Inhaled Allergens Among The Residents Of The Northern United Arab Emirates: Automated Evaluation Of A Membrane-Based Test System, Israa O. Yousif, Nazeerullah Rahamathullah, Nelofar S. Khan, Mohammad Mesbahuzzaman, Mohammed Abdulrazzaq, Fawzia A. Alobeidli, Praveen K. Kandakurti
Saudi Medical Journal
Objectives: To determine specific positive immunoglobulin E (IgE) antibodies to various inhaled allergens in residents of Ajman and the northern region of the United Arab Emirates (UAE) using an automated evaluation of a membrane-based test. Methods: A total of 104 patients’ blood samples were received from various hospitals and clinics in Ajman and other northern Emirates regions at Thumbay Laboratory, Thumbay University Hospital, Ajman, UAE, to carry out inhalation allergy tests during the study period of 12 months (February 2023 until January 2024). Using the EUROLINE immunoblotting method, 20 different inhalation allergens-impregnated latex strips were used to carry out the …
In This Issuereview Articlesystematic Revieworiginal Articlecase Report
In This Issuereview Articlesystematic Revieworiginal Articlecase Report
Saudi Medical Journal
No abstract provided.
Understanding Artificial Intelligence Through The Eyes Of Future Nurses: Insights From Nursing Students, Latifah Alenazi, Saad H. Al-Anazi
Understanding Artificial Intelligence Through The Eyes Of Future Nurses: Insights From Nursing Students, Latifah Alenazi, Saad H. Al-Anazi
Saudi Medical Journal
Objectives: To explore nursing students’ perceptions and understanding of artificial intelligence (AI), aiming to identify and address critical knowledge gaps to support effective integration into educational practices. Methods: An exploratory qualitative study was carried out using semi-structured interviews with 20 nursing students from King Saud University, Riyadh, Saudi Arabia, in October 2023. Data collection focused on their definitions, conceptualizations, and perspectives regarding AI in healthcare. Results: A total of 3 key themes emerged: I)transformation, where AI represents a shift in nursing education from traditional methods to technological integration; II) power, viewing AI as a driver of knowledge creation and scientific …
Cutaneous Metastasis Of Signet Ring Cell Adenocarcinoma Of The Colon, Assaf G. Alamri, Ahmed S. Alhujaily, Rahaf S. Alraddadi, Mustafa A. Zaytuni
Cutaneous Metastasis Of Signet Ring Cell Adenocarcinoma Of The Colon, Assaf G. Alamri, Ahmed S. Alhujaily, Rahaf S. Alraddadi, Mustafa A. Zaytuni
Saudi Medical Journal
ABSTRACT Cutaneous metastasis of colorectal cancer is uncommon. Therefore, in this case study, we present a unique case of cutaneous metastasis of signet ring adenocarcinoma. The patient presented with generalized asymptomatic subcutaneous nodules 2 years after primary tumor diagnosis. Skin metastasis appeared 3 months before the liver and lung metastasis. However, the patient died 4 months later. Therefore, clinicians should observe signs of distant metastasis of colorectal cancer to enhance survival and improve outcomes.
Mass Polio Vaccination Campaign To Continue In The Gaza Strip
Mass Polio Vaccination Campaign To Continue In The Gaza Strip
Saudi Medical Journal
No abstract provided.
Hospital Readmission After An Acute Admission To Internal Medicine: Causes And Risk Factors In A Tertiary Care Center In Saudi Arabia, Mutaz H. Althobaiti, Khaled A. Alkhowaiter, Duha K. Alahmadi, Omar S. Baharoon, Al-Zahraa S. Almahlawi, Mohammed Alqahtani, Hamdan H. Al-Jahdali, Jinan Z. Shamou, Laila A. Layqah, Salim A. Baharoon
Hospital Readmission After An Acute Admission To Internal Medicine: Causes And Risk Factors In A Tertiary Care Center In Saudi Arabia, Mutaz H. Althobaiti, Khaled A. Alkhowaiter, Duha K. Alahmadi, Omar S. Baharoon, Al-Zahraa S. Almahlawi, Mohammed Alqahtani, Hamdan H. Al-Jahdali, Jinan Z. Shamou, Laila A. Layqah, Salim A. Baharoon
Saudi Medical Journal
Objectives: To investigate the risk factors associated with single and multiple hospital readmissions within 30 days of discharge. Methods: A retrospective study carried out during 2019 at King Abdulaziz Medical City in Riyadh, Saudi Arabia. Using simple random sampling with an estimated prevalence of readmission rates between 10-20%, the calculated sample size was 200 patients. Patients were classified into 2 categories: patients with single or multiple readmissions. For comparison of categorical variables, the Chi-square test and Fisher’s exact test were employed as relevant. Means comparisons were carried out using independent samples t-test. Multivariate logistic regression analysis was implemented to identify …
Safety And Efficacy Of Weekly Somapacitan For Growth Hormone Deficiency In Children: A 72-Week Observational Study, Abdulmoein E. Al-Agha, Hasan M. Aljefri, Shahd E. Kafi, Aliaa S. Alamri, Abdullah A. Alghamdi
Safety And Efficacy Of Weekly Somapacitan For Growth Hormone Deficiency In Children: A 72-Week Observational Study, Abdulmoein E. Al-Agha, Hasan M. Aljefri, Shahd E. Kafi, Aliaa S. Alamri, Abdullah A. Alghamdi
Saudi Medical Journal
Objectives: To assess the effectiveness and safety of somapacitan, a long-acting growth hormone analog, as a promising treatment to improve adherence in pediatric growth hormone deficiency (GHD) management. Methods: The observational study included 184 children diagnosed with GHD. Carried out over 72 weeks at the Pediatric Endocrinology Outpatient Clinic in collaboration with King Abdulaziz University Hospital in Jeddah, Saudi Arabia. Patients received weekly somapacitan doses, starting at 0.16 mg/kg and adjusted according to insulin-like growth factor 1 (IGF-1) levels. Key outcomes included changes in height velocity and IGF-1 levels, with statistical significance set at a p -value of <0.05. Results: The cohort, with an average age of 10.1 years and 67.4% male, showed substantial improvements by week 72: IGF-1 levels increased from 166.97 to 363.74, and height velocity gains were most pronounced in children at Tanner Stage 1. Treatment-naive children exhibited greater initial height velocity improvements compared to those switching from daily GH therapy, although these differences leveled over time. Somapacitan was well-tolerated, with minimal side effects, supporting its long-term safety. Conclusion: Weekly somapacitan offers an effective, safe pediatric GHD treatment, with individualized dosing based on IGF-1 levels. Routine IGF-1 monitoring is advised to maximize benefits and minimize risks. Further studies on diverse populations are recommended to validate these findings in pediatric endocrinology.
The Prevalence And Predictors Of Obstructive Sleep Apnea In Patients Undergoing Bariatric Surgery In Saudi Arabia, Alaa M. Alaqeel, Mohammed A. Aldammas, Enas F. Alaraik, Faisal M. Abanumay, Salih A. Aleissi, Samar Z. Nashwan, Awad H. Olaish, Hamza O. Dhafar, Ahmed S. Bahammam
The Prevalence And Predictors Of Obstructive Sleep Apnea In Patients Undergoing Bariatric Surgery In Saudi Arabia, Alaa M. Alaqeel, Mohammed A. Aldammas, Enas F. Alaraik, Faisal M. Abanumay, Salih A. Aleissi, Samar Z. Nashwan, Awad H. Olaish, Hamza O. Dhafar, Ahmed S. Bahammam
Saudi Medical Journal
Objectives: To address a gap in the literature on the prevalence and predictors of obstructive sleep apnea (OSA) among patients undergoing bariatric surgery in Saudi Arabia, considering the region’s unique cultural and dietary practices. Methods: This retrospective study at King Saud University Medical City, Riyadh, analyzed data from morbidly obese patients referred from the bariatric surgery unit to the sleep disorders clinic. Using the Sleep Disorders Center database (September 2015 to March 2019), it examined demographic and clinical variables, with in-laboratory polysomnography (PSG) employed to diagnose and assess OSA severity. Results: The study assessed 265 morbidly obese patients for OSA …