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Clinical Role Of Hematologic Inflammatory Markers In The Diagnosis Of Missed Abortion, Mustafa Bakırcı, Çağlayan Ateş, Ethem S. Yalvaç
Clinical Role Of Hematologic Inflammatory Markers In The Diagnosis Of Missed Abortion, Mustafa Bakırcı, Çağlayan Ateş, Ethem S. Yalvaç
Saudi Medical Journal
Objectives: To evaluate the diagnostic value of hematological and biochemical inflammatory markers in distinguishing missed abortions from healthy pregnancies during the first trimester. Methods: This retrospective case-control study was conducted between May 2022 and May 2024, included 61 women diagnosed with missed abortion by ultrasound and 100 healthy pregnant women who acted as controls. The following inflammatory markers were calculated from routine blood and biochemistry results: neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), monocyte-lymphocyte ratio (MLR), lymphocyte-monocyte ratio (LMR), systemic immune-inflammation index (SII) and C-reactive protein-albumin ratio (CAR). Intergroup comparisons and receiver operating characteristic (ROC) curve analyses were performed. Results: The …
Concurrent Appendectomy In Patients Undergoing Surgery For Gynecological Malignancies: A Retrospective Analysis From A Tertiary Referral Center, Gazi Güner, Can Tercan, Emrah Dağdeviren, Ali Selçuk Yeniocak, Ceylin Elbistanli, Sure Nur Erdoğmuş, Ayşe Hazirbulan, Yiğit Mert Bayrak, Neçirvan Çağdaş Çaltek, Gözde Şahin, Ergun Tercan, Figen Efe Çamili, Nazlıaylin Vural, Hüseyin Karatay, Saniye Merve Gül Kara, İlkbal Temel Yüksel
Concurrent Appendectomy In Patients Undergoing Surgery For Gynecological Malignancies: A Retrospective Analysis From A Tertiary Referral Center, Gazi Güner, Can Tercan, Emrah Dağdeviren, Ali Selçuk Yeniocak, Ceylin Elbistanli, Sure Nur Erdoğmuş, Ayşe Hazirbulan, Yiğit Mert Bayrak, Neçirvan Çağdaş Çaltek, Gözde Şahin, Ergun Tercan, Figen Efe Çamili, Nazlıaylin Vural, Hüseyin Karatay, Saniye Merve Gül Kara, İlkbal Temel Yüksel
Saudi Medical Journal
Objectives: To evaluate appendectomy specimen findings and their association with tumor type and stage. Concurrent appendectomy is frequently performed during gynecologic oncology surgery to prevent postoperative appendicitis and detect occult pathology, yet its value remains debated. Methods: In this study, we reviewed the medical records of 300 women who underwent gynecologic oncologic surgery accompanied by appendectomy at Başakşehir Çam and Sakura City Hospital (Istanbul, Türkiye) over the period from July 2020 to April 2025. Clinical, surgical, andhistopathologic data were collected. Appendiceal pathologies were categorized as reactive hyperplasia, chronic inflammation, benign neoplasms, metastatic tumors, or primary. Statistical analyses included chi-square, t-test, …
Reliability And Validity Of The Arabic Version Of The Nose-Perf Scale, Rayan M. Alfallaj, Abdullah I. Binghaith, Mohammed Y. Alyoussef, Ahmed S. Alsaleh, Saad A. Alsaleh, Abdulaziz A. Alqahtani, Ahmad S. Alroqi
Reliability And Validity Of The Arabic Version Of The Nose-Perf Scale, Rayan M. Alfallaj, Abdullah I. Binghaith, Mohammed Y. Alyoussef, Ahmed S. Alsaleh, Saad A. Alsaleh, Abdulaziz A. Alqahtani, Ahmad S. Alroqi
Saudi Medical Journal
Objectives: To assess the psychometric validity of the Arabic adaptation of the nasal obstruction symptom evaluation–perforation (NOSE-Perf) scale. To assess how reliable and valid the Arabic adaptation of the NOSE-Perf questionnaire is. Patients with septal perforations, particularly Arabic speakers, lack validated self-assessment tools for subjective symptom evaluation. Methods: Conducted between May 2024 and June 2025, the study included 100 participants—20 patients with septal perforation and 80 controls. Participants filled out a questionnaire consisting of demographic data as well as the Arabic forms of the Sino-Nasal Outcome Test-22 (SNOT-22), NOSE, and NOSE-Perf scales. Cronbach's alpha was applied to determine internal consistency, …
A Multi-Centre Study: Quantitative Evaluation Of Radiation Dose For Adults Head Computed Tomography, Abdulaziz A. Qurashi, Shrooq T. Aldahery
A Multi-Centre Study: Quantitative Evaluation Of Radiation Dose For Adults Head Computed Tomography, Abdulaziz A. Qurashi, Shrooq T. Aldahery
Saudi Medical Journal
Objectives: To determine regional radiation dose in adults head computed tomography (CT) examinations in Jeddah by assessing the volume computed tomography dose index (CTDIvol) and dose length product (DLP) values. Methods: A retrospective study was conducted from February to April 2025 across 10 CT scanners from 5 governmental hospitals in Jeddah. Data for 20 head CT examinations per scanner were collected. Dose metrics including CTDIvol and DLP (mGy·cm), were extracted from digital imaging and communications in medicine (DICOM) images. Mean values per scanner and the 75th percentile were calculated across centres to identify the regional DRL. …
The Role Of The Delta Neutrophil Index In Determining The Severity Of Intrahepatic Cholestasis Of Pregnancy, Selçuk Atalay, Melike Çaltekin, Nihal Çallıoğlu, Fırat Ersan, Verda Alpay, Yasin Anasız, Ipek Geyikoğlu
The Role Of The Delta Neutrophil Index In Determining The Severity Of Intrahepatic Cholestasis Of Pregnancy, Selçuk Atalay, Melike Çaltekin, Nihal Çallıoğlu, Fırat Ersan, Verda Alpay, Yasin Anasız, Ipek Geyikoğlu
Saudi Medical Journal
Objective: This study aimed to investigate the clinical utility of the delta neutrophil index (DNI) in distinguishing patients with intrahepatic cholestasis of pregnancy (ICP) from healthy pregnant women, and to assess its potential role in evaluating disease severity. Methods: This retrospective analysis included data from 249 pregnant women. Among them, 131 were identified with ICP, based on clinical symptoms and total bile acid levels ≥ 10 μ mol/L. The remaining 118 participants served as healthy controls. The ICP cases were categorized into mild (TBA 10–39 μ mol/L; n = 90) and severe (TBA ≥ 40 μ mol/L; n = 41) …
Integrative Approaches To Gut Microbiota: Biomarkers, Dysbiosis, And Therapeutic Potential, Zeyad M. Alharbi
Integrative Approaches To Gut Microbiota: Biomarkers, Dysbiosis, And Therapeutic Potential, Zeyad M. Alharbi
Saudi Medical Journal
The human gut contains bacteria, viruses, and archaea that influence health depending on age, diet, and location. An individual harbours about 150 bacterial species. An imbalance of these microorganisms, known as dysbiosis, can negatively impact health. Commensal bacteria maintain microbial homeostasis by building short chain fatty acids. The 2-way communication channel that connects the gut and the brain is referred to as the gut-brain axis. Dysbiosis of the gut leads to some autoimmune diseases. A decline of beneficial bacteria causes the progression of rheumatoid arthritis. Gut dysbiosis increases intestinal permeability, allowing toxins and cytokines to enter the bloodstream and damage …
Emerging Nanotherapy Applications In Cancer Treatment: A Comprehensive Review, Waleed H. Mahallawi
Emerging Nanotherapy Applications In Cancer Treatment: A Comprehensive Review, Waleed H. Mahallawi
Saudi Medical Journal
This comprehensive review synthesizes recent advances in cancer nanotherapy, focusing on 6 emerging categories: immunomodulation, gene/RNA delivery, theranostics, radiosensitization, biomimetic carriers, and artificial intelligence (AI)-guided formulations. These innovative platforms demonstrate transformative potential by overcoming key limitations of conventional cancer treatments. Immunomodulatory nanoparticles reprogram tumor microenvironments and convert immunologically ``cold'' tumors to ``hot'' responsive states. Gene delivery systems enable precise editing with >50% efficiency, while theranostic platforms integrate real-time imaging with targeted therapy. Radiosensitizers amplify local radiation dose by twofold, and biomimetic carriers achieve prolonged circulation through immune evasion. An AI-driven approaches optimize personalized formulations based on patient-specific biomarkers. Clinical evidence …
Treatment Of Odontogenic Sinusitis With Oroantral Communication And Fistula: A Systematic Review And Meta-Analysis, Rana R. Alharbi, Omar F. Alnajar, Reham E. Almahdi, Salman A. Alrougi, Remas A. Alshehri, Ruyuf A. Alotaibi, Shahad S. Alharbi, Manal A Eltahir, Yahya A. Fageeh
Treatment Of Odontogenic Sinusitis With Oroantral Communication And Fistula: A Systematic Review And Meta-Analysis, Rana R. Alharbi, Omar F. Alnajar, Reham E. Almahdi, Salman A. Alrougi, Remas A. Alshehri, Ruyuf A. Alotaibi, Shahad S. Alharbi, Manal A Eltahir, Yahya A. Fageeh
Saudi Medical Journal
Objective: To assess the available data regarding medicinal, surgical, and combination therapy approaches for odontogenic sinusitis linked to OAC and OAF. Oroantral communication (OAC), an atypical connection between the oral cavity and maxillary sinus, commonly arises following upper jaw procedures, trauma, or infection. Chronic odontogenic maxillary sinusitis may result from OAC developing into an oroantral fistula (OAF) if treatment is not received. Recurrent infections and functional difficulties can be avoided by managing these illnesses effectively. Methods: A systematic search was conducted in National Library of Medicine's (PubMed [MEDLINE]) and Google Scholar for studies published between 2000 and 2024. A total …
Mental Health In Relation To Parental Absence: A Systematic Review, Mohammed Barry, Abdulaziz Alyahyawi, Heba Jafar Sabbagh
Mental Health In Relation To Parental Absence: A Systematic Review, Mohammed Barry, Abdulaziz Alyahyawi, Heba Jafar Sabbagh
Saudi Medical Journal
Objective: To evaluate the literature based on the relationship between orphaned children and mental health, compared to non-orphaned children. Mental well-being of orphaned children is a profound intricate topic that connects with broader concerns of childcare. This systematic review aims to evaluate the literature regarding the relationship between mental health and parental absence. Methods: We conducted a systematic search of PubMed, MEDLINE, and Science Direct in October 2025, with 1017 screened studies. Six studies met the inclusion criteria. Independent reviewers performed quality assessments using the Newcastle-Ottawa scale (NOS). Subsequently, a meta-analysis was performed when possible. Results: Findings indicate that orphaned …
Chronic Total Occlusion Percutaneous Coronary Intervention: A Consensus Of The National Heart Center In Collaboration With The Saudi Cto Club Of The Saudi Arabian Cardiac Interventional Society, Waqar H. Ahmed, Khalid Aljohani, Sultan Alotaibi, Motasem Alyamani, Mohammed Almohammadi, Ahmed Alhamami, Hani Abdelhadi, Owayed Alshammeri, Abdullah Alsaiedi, Abdulrahman Almoghairi, Abdulrahman Qahtani, Saleh Khouj, Shatha Alalawi, Walid Alharbi
Chronic Total Occlusion Percutaneous Coronary Intervention: A Consensus Of The National Heart Center In Collaboration With The Saudi Cto Club Of The Saudi Arabian Cardiac Interventional Society, Waqar H. Ahmed, Khalid Aljohani, Sultan Alotaibi, Motasem Alyamani, Mohammed Almohammadi, Ahmed Alhamami, Hani Abdelhadi, Owayed Alshammeri, Abdullah Alsaiedi, Abdulrahman Almoghairi, Abdulrahman Qahtani, Saleh Khouj, Shatha Alalawi, Walid Alharbi
Saudi Medical Journal
Objective: Chronic total occlusion (CTO) is one of the most complex and technically demanding percutaneous coronary interventions (PCI). Over the last two decades, technological and procedural advancements have significantly improved clinical outcomes. However, CTO-PCI practice and outcomes remain suboptimal with a lack of standardized approaches. Methods: The Saudi CTO Club has been actively working to enhance collaboration among CTO operators throughout the region. The National Heart Center (NHC), in collaboration with the Saudi Arabian Cardiac Interventional Society (SACIS), convened national experts to develop a consensus document and workflow for integrating CTO-PCI into clinical practice in Saudi Arabia. This consensus document …
Epidemiological Mapping Of Drug-Susceptible And Resistant Tuberculosis In 30 Who High-Burden Countries: Three Decades Of Gbd 2023 Trends, Projections To 2043 And Concordance With Who Estimates, Azfar A. Ishaqui, Salman A. Ahmad, Shoaib Alam, Narendar Kumar, Javeria Farooq, Khalid Orayj, Rabbiya Ahmad, Mohammed Zawiah, Mustapha Mohammed, Muhammad Imran, Asaad A. Asaad Khalil, Mohammed A. Kaddoura, Sultan M. Alshahrani, Adnan Iqbal, Muhammad B. Maqsood
Epidemiological Mapping Of Drug-Susceptible And Resistant Tuberculosis In 30 Who High-Burden Countries: Three Decades Of Gbd 2023 Trends, Projections To 2043 And Concordance With Who Estimates, Azfar A. Ishaqui, Salman A. Ahmad, Shoaib Alam, Narendar Kumar, Javeria Farooq, Khalid Orayj, Rabbiya Ahmad, Mohammed Zawiah, Mustapha Mohammed, Muhammad Imran, Asaad A. Asaad Khalil, Mohammed A. Kaddoura, Sultan M. Alshahrani, Adnan Iqbal, Muhammad B. Maqsood
Saudi Medical Journal
Objectives: Tuberculosis (TB) continues to drive infectious mortality worldwide. The study characterized the evolution of drug-susceptible TB (DS-TB), multidrug-resistant TB (MDR-TB), and extensively drug-resistant TB (XDR-TB) in 30 WHO high-burden countries, linking current patterns to long-term trends, age structure, and forward-looking scenarios to 2043. Methods: Using GBD 2023 estimates for 1990–2023, we extracted incidence, mortality, and DALYs as age-standardized rates (ASR) per 100,000 with 95% uncertainty intervals. Temporal dynamics were summarized with Estimated Annual Percent Change (EAPC) and extended linearly to 2043. GBD incidence and mortality were compared against WHO national TB series for 2010–2023. Results: Overall TB incidence ASR …
Validity And Reliability Of The Arabic Voice Activity And Participation Profile (A-Vapp) Questionnaire, Nawaf S. Alqarni, Hamad F. Alrabiah, Nasser F. Alsunbul, Manal A. Bukhari, Mohamed Farahat, Mohammed Almohizea, Tamer A. Mesallam, Khalid H. Malki
Validity And Reliability Of The Arabic Voice Activity And Participation Profile (A-Vapp) Questionnaire, Nawaf S. Alqarni, Hamad F. Alrabiah, Nasser F. Alsunbul, Manal A. Bukhari, Mohamed Farahat, Mohammed Almohizea, Tamer A. Mesallam, Khalid H. Malki
Saudi Medical Journal
Objectives: The purpose of this study was to translate and validate the Voice Activity and Participation Profile (VAPP), a comprehensive tool for assessing the impact of voice disorders on daily life activities and social participation, into Arabic and to test its reliability among voice disorders patients in Riyadh, Saudi Arabia \looseness-1 Methods: A descriptive, questionnaire-based validation study was conducted at two university hospitals from December 2023 to September 2024. The VAPP was translated using forward and backward translation methods from English into Arabic. The questionnaire's reliability and internal consistency were assessed using Cronbach's alpha and test-retest reliability. To measure …
Stratifying Renal Risk In End-Stage Renal Disease: Evidence From A Population-Based Dialysis Registry In Northern Saudi Arabia, Reem Eltayeb, Naif K Binsaleh, Ghaida A Alsaif, Mona Hm Ahmed, Ahmed M Taha, Abdelhameed Abdelzaher, Zinab Alatawi
Stratifying Renal Risk In End-Stage Renal Disease: Evidence From A Population-Based Dialysis Registry In Northern Saudi Arabia, Reem Eltayeb, Naif K Binsaleh, Ghaida A Alsaif, Mona Hm Ahmed, Ahmed M Taha, Abdelhameed Abdelzaher, Zinab Alatawi
Saudi Medical Journal
Objectives: We examined the relationship of age, gender, smoking, nationality, and place of residence with renal dysfunction severity in end-stage renal disease (ESRD) patients. Methods: We performed a cross-sectional study of ESRD registry data collected from King Khalid Hospital in Hail, Saudi Arabia. Adults (≥ 15 years) treated from March 2023 - February 2024 were enrolled. Serum creatinine and urinary albumin concentrations were measured (based on primary [≥ 625 μmol/L and ≥ 18 mg/L, respectively] and sensitivity thresholds). Bivariate analyses, interaction testing, sensitivity models, and multivariable logistic regression were employed. Results: Of 212 patients (50.9% male), based on primary thresholds, …
Critically Ill Patients Presenting To The Emergency Department; Outcome Review In A Tertiary Care Center, Maan Jamjoom, Lina Sami Reda, Bsaim Abdulsalam Altirkistani, Samer Tariq Anwar Ahmed, Samer Ali Alasmari, Abdulrahman Adnan Almehmadi, Ahmad Loay Atiah, Faisal Abdulaziz Boker, Rand Ayman Maddah
Critically Ill Patients Presenting To The Emergency Department; Outcome Review In A Tertiary Care Center, Maan Jamjoom, Lina Sami Reda, Bsaim Abdulsalam Altirkistani, Samer Tariq Anwar Ahmed, Samer Ali Alasmari, Abdulrahman Adnan Almehmadi, Ahmad Loay Atiah, Faisal Abdulaziz Boker, Rand Ayman Maddah
Saudi Medical Journal
Objective: Critically ill patients presenting to the emergency department require prompt recognition and prioritized care due to the severity of their conditions. Reviewing their clinical outcomes helps guide future planning and resource allocation. This study aims to highlight the outcomes of patients triaged as CTAS I and II in the emergency department of a tertiary care center in Jeddah, Saudi Arabia. Methods: A single-center retrospective cohort study was conducted in the emergency department of a tertiary healthcare center, National Guard Health Affairs, in Jeddah. The study provides a comprehensive assessment of factors (including length of stay) and outcomes for a …
Microbiological Profile And Antibiotic Resistance In Relation To Risk Of Recurrence And Fistula Following Perianal Abscess Drainage: A Retrospective Study, Saleh A. Busbait
Microbiological Profile And Antibiotic Resistance In Relation To Risk Of Recurrence And Fistula Following Perianal Abscess Drainage: A Retrospective Study, Saleh A. Busbait
Saudi Medical Journal
Objective: The practice of obtaining routine intraoperative cultures and administering postoperative antibiotics for perianal abscess treatment continues to be debated, so far, there is no established evidence linking these practices to improved patient outcomes. This study investigated the microbial distribution together with antibiotic resistance and their relationship to abscess recurrence or fistula development. Methods: The study analyzed 242 patients who received their first perianal abscess treatment through incision and drainage procedures at a Saudi Arabian tertiary center from 2019 to 2023. Swab cultures were obtained intraoperatively. A descriptive statistics, Chi-square tests and antibiotic resistance were analyzed. Results: The most frequently …
An Investigation Of The Correlation Between Total Intracranial Volume And Body Mass Index, Walaa M. Alsharif, Fahad H. Alhazmi, Ali D. Almutairi, Rahaf M. Alharbi, Lana M. Alsaedi, Razan A. Alharbi, Amirah F. Alsaedi, Abdulaziz A. Qurashi, Adnan A. Alahmadi, Khalid M. Alshamrani, Faisal A. Alrehily, Shrooq T. Aldahery, Osamah M. Abdulaal, Reem M. Elkady
An Investigation Of The Correlation Between Total Intracranial Volume And Body Mass Index, Walaa M. Alsharif, Fahad H. Alhazmi, Ali D. Almutairi, Rahaf M. Alharbi, Lana M. Alsaedi, Razan A. Alharbi, Amirah F. Alsaedi, Abdulaziz A. Qurashi, Adnan A. Alahmadi, Khalid M. Alshamrani, Faisal A. Alrehily, Shrooq T. Aldahery, Osamah M. Abdulaal, Reem M. Elkady
Saudi Medical Journal
\looseness-1 Objective: Total intracranial volume (TICV) is an important covariate in brain volumetric analysis that can vary significantly between participants. This study aimed to investigate the association between body mass index (BMI) and TICV. Methods: 152 healthy volunteers were recruited. The BMI was calculated, and T1-weighted images were acquired to estimate brain volumetric values. The data were analyzed using volBrain software. Results: Male participants have significantly higher GM, WM, CSF, TICV, cerebellum GM, cortical GM, subcortical GM and cerebrum GM volumes compared to female. There were significant differences in GM, TICV, cerebellum GM, cortical GM, subcortical GM and cerebrum GM …
A Comprehensive Analysis Of Overweight, Obesity, And Failure To Thrive In Pediatric Inpatients: Prevalence, Diagnostic Practices, And Management Approaches At A Tertiary Hospital In Riyadh, Saudi Arabia, Ibrahim A Al Alwan, Elaf A Alshammari, Ahmed A Alabdulkarim, Abdulaziz A Ajeebi, Afnan A Alhazimi, Nawaf A Alhamied, Deema Y Alasmari
A Comprehensive Analysis Of Overweight, Obesity, And Failure To Thrive In Pediatric Inpatients: Prevalence, Diagnostic Practices, And Management Approaches At A Tertiary Hospital In Riyadh, Saudi Arabia, Ibrahim A Al Alwan, Elaf A Alshammari, Ahmed A Alabdulkarim, Abdulaziz A Ajeebi, Afnan A Alhazimi, Nawaf A Alhamied, Deema Y Alasmari
Saudi Medical Journal
Objective: This study aimed to assess the prevalence, diagnostic accuracy, and inpatient management of pediatric weight abnormalities at a tertiary children's hospital in Riyadh, Saudi Arabia, using a retrospective cohort design. Methods: The study analyzed medical records of pediatric inpatients aged 2–14 years admitted to King Abdullah Specialized Children's Hospital (KASCH) in 2023. Data collected included anthropometrics, dietary history, physical activity, diagnostic workup, and treatment plans. Overweight and obesity were classified using BMI percentiles, while FTT was identified via weight-for-age and growth percentile criteria. Descriptive statistics were used to analyze diagnostic accuracy and factors influencing missed diagnoses. Results: Of 7,771 …
Mapping Health Research Involving Human Subjects In Saudi Arabia: A Text Mining And Topic Modeling Analysis, Khalid A. Alhussain
Mapping Health Research Involving Human Subjects In Saudi Arabia: A Text Mining And Topic Modeling Analysis, Khalid A. Alhussain
Saudi Medical Journal
Objectives: To identify dominant and underrepresented research topics and to classify published studies by design and data sources in health research involving human subjects from Saudi Arabia. Methods: This retrospective study analyzed PubMed-indexed health articles related to Saudi Arabia from 1959 to March 2025. Text mining was used to identify studies conducted in the country involving human subjects. Eligible articles were classified by study design and data sources. Topic modeling using non-negative matrix factorization was applied to identify topics based on the primary research focus. Results: A total of 36,452 records of studies conducted in Saudi Arabia were initially identified. …
Translational Barriers To Aav And Crispr Gene Therapy In Diabetes, Abdulrahman G. Alharbi
Translational Barriers To Aav And Crispr Gene Therapy In Diabetes, Abdulrahman G. Alharbi
Saudi Medical Journal
Gene therapy targets diabetes pathophysiology rather than symptoms, yet clinical translation is slower than preclinical success. This review synthesizes 143 registered trials (ClinicalTrials.gov, 2010-2025) identifying systematic implementation barriers. Despite >15 years of development, 83% of trials remain in Phase I-II. Only zimislecel achieved Phase III outcomes (83% insulin independence at 12 months, n=12, requiring immunosuppression). VM202 for diabetic neuropathy failed Phase III despite positive extension results. Three systematic barriers emerged: (1) human transduction efficiency is 6-8.7-fold lower than preclinical models; (2) pre-existing immunity excludes 58-78% of candidates; (3) manufacturing capacity serves <2.5% of target population (40-400 years to treat at maximum capacity). These constraints explain why ex vivo cell therapies advanced to efficacy trials while in vivo gene delivery remains in Phase I despite longer development timelines. Research priorities should emphasize non-viral delivery systems offering scalable manufacturing and universal hypoimmune donor cells to address access barriers.
Semaglutide In Metabolic Medicine: A Review On Clinical Applications And Emerging Therapeutics, Abdulrahman A. Aljabri
Semaglutide In Metabolic Medicine: A Review On Clinical Applications And Emerging Therapeutics, Abdulrahman A. Aljabri
Saudi Medical Journal
Obesity and type 2 diabetes mellitus affect over 800 million and 537 million individuals worldwide. Semaglutide, a weekly glucagon-like peptide-1 receptor agonist, has advanced treatment of pathophysiological processes linked to metabolic dysregulation. This review consolidates evidence on its mechanisms of action, clinical effectiveness across established and emerging applications, safety, and prospects for personalized therapy. Clinical studies have shown that semaglutide sustains glycemic control, promotes substantial weight loss, and provides cardiovascular and renal protection. Recent FDA clearance marks the first therapeutic alternative for metabolic dysfunction-associated steatohepatitis among the emerging applications. Pharmacogenomic insights facilitate personalized therapy; however, clinical applications remain in experimental …
Rehabilitation Outcomes Of Pediatric Burn Survivors In Saudi Arabia: A Thematic Narrative Review And Policy Implications, Abdulaziz Ghandurah, Mshari Alghadier
Rehabilitation Outcomes Of Pediatric Burn Survivors In Saudi Arabia: A Thematic Narrative Review And Policy Implications, Abdulaziz Ghandurah, Mshari Alghadier
Saudi Medical Journal
Pediatric burns in Saudi Arabia are predominantly household scalds in young children, causing long-term disability from scarring, contractures, pain/itch, psychosocial distress, and disrupted schooling. This thematic narrative review (2010–2025) synthesizes global and regional evidence, appraises outcome measures with attention to Arabic availability, and translates findings into Vision 2030–aligned policy actions. Evidence supports early, multidisciplinary care anchored in standardized outcome tracking. Pressure-garment therapy remains inconclusive, whereas virtual reality reduces procedural pain and telerehabilitation serves families distant from tertiary centers. A minimum national outcome set is proposed spanning scar quality (VSS, POSAS), joint range of motion, age-appropriate pain and itch scales (FLACC/FPS-R/NRS), …
Understanding The Cost Consequences Of Pharmacist Roles In Managing Long-Term Illnesses: A Systematic Review, Muhammad Zahid Iqbal
Understanding The Cost Consequences Of Pharmacist Roles In Managing Long-Term Illnesses: A Systematic Review, Muhammad Zahid Iqbal
Saudi Medical Journal
Objective: This review looked at how different pharmacist-led services influence medication spending and other economic outcomes for people living with long-term illnesses. Methods: To gather the evidence, we followed the PRISMA 2020 approach and a comprehensive search was conducted using multiple sources, including Web of Science, ProQuest, Scopus, the Directory of Open Access Journals, ScienceDirect, PubMed, and Google Scholar. We included studies that examined pharmacist involvement in medication management such as MTM, medication reconciliation, deprescribing efforts, or full medication reviews and that reported some form of cost or economic outcome in chronic disease care. We left out non-English work, conference …
Impact Of Clinical Pharmacist Educational Intervention On Lipid Profile And Its Clinical Outcomes, Saad Saeed Alqahtani
Impact Of Clinical Pharmacist Educational Intervention On Lipid Profile And Its Clinical Outcomes, Saad Saeed Alqahtani
Saudi Medical Journal
Objective: To assess how clinical pharmacist-led educational interventions affect lipid profile parameters and related clinical outcomes in cardiovascular disease-risk individuals. Methods: This systematic review completed as according to PRISMA 2020 principles. Searches were done on PubMed, ScienceDirect, ProQuest, Google Scholar, DOAJ, Scopus, and Web of Science. Studies examining impact of the pharmacists' educational initiatives on lipid levels were included. However, case reports, conference proceedings, and studies in other languages not in English, and studies lacking full-text access were excluded from the review. Following screening and eligibility assessment, a total of 33 papers were included out of the 1731 records found. …
Reengineering Cardiac Rehabilitation For Women: From Access To Equity, Juwairia Alali
Reengineering Cardiac Rehabilitation For Women: From Access To Equity, Juwairia Alali
Saudi Medical Journal
Cardiac rehabilitation (CR) is a corner stone intervention in secondary prevention of cardiovascular disease where a multidisciplinary team provides tailored management of lifestyle interventions, exercise and behavioural counselling. Participating in CR resulted in better rates of tobacco cessation, blood pressure and cholesterol lowering and better glycaemic control [1]. CR participation results in significant lower mortality and hospitalizationand improved quality of life. Despite the body of evidence and the robust recommendation by international guidelines it remains underutilized especially by women.
Bridging The Gender Gap In Cardiovascular Care: A Framework For Women's Heart Care, Julia Grapsa, Ana G Almeida
Bridging The Gender Gap In Cardiovascular Care: A Framework For Women's Heart Care, Julia Grapsa, Ana G Almeida
Saudi Medical Journal
No abstract provided.
Management Of Arrhythmias During Pregnancy In Africa, Mervat Aboulmaaty, Kirellos Mikhail, Bola Sogade
Management Of Arrhythmias During Pregnancy In Africa, Mervat Aboulmaaty, Kirellos Mikhail, Bola Sogade
Saudi Medical Journal
Cardiac arrhythmias represent a significant clinical concern that have been always addressed. Moreover, Pregnancy introduces profound hormonal, autonomic, and hemodynamic changes that add more risk to cardiac patients and increase arrhythmia susceptibility. In our continent, Africa, there is an added risk because of the high prevalence of rheumatic heart disease, peripartum cardiomyopathy, and limited access to healthcare, contributing to adverse maternal and fetal outcomes. This article addresses the epidemics, mechanisms, and management of arrhythmias during pregnancy in African settings, highlighting high-yield real-life cases. We focus on guideline-based management strategies, emphasizing fetal safety, and discuss unique regional challenges, including limited access …
Women’S Cardiovascular Health In 2025: Advancements Achieved, Challenges Ahead, Jamilah S. Alrahimi
Women’S Cardiovascular Health In 2025: Advancements Achieved, Challenges Ahead, Jamilah S. Alrahimi
Saudi Medical Journal
Cardiovascular disease (CVD) is the leading cause of death among women globally. Recognition of sex-specific risk factors, pathophysiology, and clinical presentations has established women's cardiovascular health as a research and clinical priority. Pregnancy complications, premature menopause, and autoimmune disease, are now identified as long-term contributors to cardiovascular risk, while female-predominant syndromes such as ischemia with non-obstructive coronary arteries and heart failure with preserved ejection fraction are increasingly acknowledged. Novel therapies and updated guidelines emphasize psychosocial determinants, reproductive history, and postpartum risk assessment in prevention and management. Despite these advances, women remain underdiagnosed, undertreated, and underrepresented in clinical trials. Diagnostic delays …
Advancing Research For Women’S Cardiovascular Health: A Clinical & Policy Priority Of The Middle East & Mediterranean Women’S Cardiovascular Research Consortium, Mirvat Alasnag
Saudi Medical Journal
No abstract provided.
National Heart Center – Saudi Health Council Acute Myocardial Infarction-Related Cardiogenic Shock Consensus Document, Mirvat Alasnag, Abdulrahman Asiri, Hazim Alrahbi, Nhatem Aloui, Ashraf M Anwar, Saad Alhassani, Maryam Mohamed Alqaseer, Ismail Raid Raslan, Ibrahim Albakri, Ahmed Almustafa, Rowa Attar, Faisal Katbi, Feras Khaleil, Alyaa Elhazmi, Adel Tash, Jehad Alburaiki
National Heart Center – Saudi Health Council Acute Myocardial Infarction-Related Cardiogenic Shock Consensus Document, Mirvat Alasnag, Abdulrahman Asiri, Hazim Alrahbi, Nhatem Aloui, Ashraf M Anwar, Saad Alhassani, Maryam Mohamed Alqaseer, Ismail Raid Raslan, Ibrahim Albakri, Ahmed Almustafa, Rowa Attar, Faisal Katbi, Feras Khaleil, Alyaa Elhazmi, Adel Tash, Jehad Alburaiki
Saudi Medical Journal
Objective: Cardiogenic shock (CS) remains a serious complication of acute myocardial infarction (AMI) with persistently high mortality and significant variability in management across centers. Methods: A multidisciplinary panel convened by the National Heart Center used the GRADE framework to review evidence and develop consensus recommendations tailored to AMI-related CS. Results: The document emphasizes standardized CS definition and staging, prioritizing the SCAI classification. Key components include early recognition, haemodynamic assessment, lactate monitoring, and the central role of echocardiography. Recommendations support rapid culprit-vessel revascularization, early consideration of mechanical circulatory support, and structured Heart Team activation. The document also highlights the need for …
Evaluating The Diagnostic Accuracy Of Ultrasound And Clinical Predictors In Pediatric Acute Tip Appendicitis: A Retrospective Study From A Tertiary Center In Saudi Arabia, Abdullah M. Abu Qarnayn, Saud A. Aljadaan, Suliaman M. Alaqeel, Faisal S. Alshehri, Abdullrzak N. Algosear, Waleed A. Alharthi, Munirah A. Alsukait, Kholoud S Alshaya
Evaluating The Diagnostic Accuracy Of Ultrasound And Clinical Predictors In Pediatric Acute Tip Appendicitis: A Retrospective Study From A Tertiary Center In Saudi Arabia, Abdullah M. Abu Qarnayn, Saud A. Aljadaan, Suliaman M. Alaqeel, Faisal S. Alshehri, Abdullrzak N. Algosear, Waleed A. Alharthi, Munirah A. Alsukait, Kholoud S Alshaya
Saudi Medical Journal
Objective: To examines the diagnostic accuracy of ultrasound (US) and the clinical characteristics of pediatric ATA. Acute tip appendicitis (ATA), a rare form of appendiceal inflammation confined to the distal tip, presents with atypical symptoms and is difficult to diagnose. The Confirmation often relies on imaging and surgical pathology. Methods: A Retrospective cross-sectional study conducted at a tertiary hospital in Riyadh, Saudi Arabia, from 2020 to 2024. Among 4,224 pediatric patients with acute appendicitis under 14 years, and our sample size of 59 patients were diagnosed with ATA by US. Firth logistic regression was used to reduce bias in the …