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Alcoholic Liver Disease. Are There Any Differences Between China And Western Countries In Clinical Features?, Shi-Hua Zheng, You-Ming Li, Shao-Hua Chen, Hai-Xiu Huang, Guang-Jin Yuan
Alcoholic Liver Disease. Are There Any Differences Between China And Western Countries In Clinical Features?, Shi-Hua Zheng, You-Ming Li, Shao-Hua Chen, Hai-Xiu Huang, Guang-Jin Yuan
Saudi Medical Journal
OBJECTIVE: To investigate the clinical features of alcoholic liver disease (ALD) in hospitalized Chinese patients, and their differences compared with western countries. METHODS: Four hundred and eight hospitalized patients with ALD at First Affiliated Hospital of Zhejiang University College of Medicine, Hangzhou, from January 2008 to December 2010 were studied retrospectively. Clinical data were analyzed and compared with western countries through literature review. RESULTS: The patients with ALD accounted for 7.8% of all hospitalized patients with liver diseases. These patients comprised 400 men and 8 women, aged between 45 and 55 years. Among the patients, there were 318 patients with …
Etiological Profile Of Omani Women With Recurrent Pregnancy Loss, Saniya M. Eltayeb, Safa K. Ambusaidi, Vaidyanathan Gowri, Wadha M. Alghafri
Etiological Profile Of Omani Women With Recurrent Pregnancy Loss, Saniya M. Eltayeb, Safa K. Ambusaidi, Vaidyanathan Gowri, Wadha M. Alghafri
Saudi Medical Journal
OBJECTIVE: To define the different causes of recurrent pregnancy loss (RPL) among Omani women. METHODS: This retrospective study included all women with RPL seen between June 2006 and March 2012 in the RPL outpatient clinic in Sultan Qaboos University hospital, Muscat, Oman. The data were collected from the Hospital Information System by screening the electronic records of these patients. The sample size gathered during the study period was 290 women. RESULTS: One hundred and forty (48%) of the examined patients had an identifiable cause for RPL, while in 150 (52%), no cause was identified. The most common causes were immunological …
The Perception Of Otolaryngology-Related Diseases Among Parents Of Children With Down Syndrome In Jeddah, Saudi Arabia, Talal Al-Khatib, Abdulrahman M. Althubaiti, Duha G. Ahmed
The Perception Of Otolaryngology-Related Diseases Among Parents Of Children With Down Syndrome In Jeddah, Saudi Arabia, Talal Al-Khatib, Abdulrahman M. Althubaiti, Duha G. Ahmed
Saudi Medical Journal
OBJECTIVE: To assess the perception of otolaryngology-related diseases among parents of children with Down syndrome (DS). METHODS: A cross-sectional survey design. A questionnaire was distributed to parents of children with DS. The parents were attending an event aiming to raise awareness that was organized on World Down Syndrome Day on the 21st of March 2013, organized by Princess Al-Jawhara Center of Excellence in Research of Hereditary Disorders, King Abdulaziz University, Jeddah, Saudi Arabia. The complete dates of study were March to May 2013. RESULTS: Questionnaires were completed and perceptions regarding 10 common otolaryngology-related diseases were obtained from 78 parents. The …
Formative Assessment In Health Professional Education, Fawaz S. Al-Otaibi
Formative Assessment In Health Professional Education, Fawaz S. Al-Otaibi
Saudi Medical Journal
No abstract provided.
The Prevalence, Causes, And Relativity Of Dental Anxiety In Adult Patients To Irregular Dental Visits, Balgis O. Gaffar, Adel S. Alagl, Asim A. Al-Ansari
The Prevalence, Causes, And Relativity Of Dental Anxiety In Adult Patients To Irregular Dental Visits, Balgis O. Gaffar, Adel S. Alagl, Asim A. Al-Ansari
Saudi Medical Journal
OBJECTIVE: To assess the frequency and causes of dental anxiety and their relation to irregular dental visits among adult dental patients. METHODS: The Dental Anxiety Question (DAQ) included within a self-administered questionnaire was distributed to 1025 patients attending the Interns9 Dental Clinics in the Department of Preventive Dental Sciences, College of Dentistry, University of Dammam, Dammam, Kingdom of Saudi Arabia from March 2012 to February 2013. A cross-sectional study design was used. The questionnaire consisted of 22 closed-ended questions divided into 4 sections; 1) demographics, 2) regularity of dental visits, and related causes, 3) DAQ, cancellation of dental appointments, history …
General Public Knowledge, Preferred Dosage Forms, And Beliefs Toward Medicines In Western Saudi Arabia, Mahmoud S. Alhaddad, Qasem M. Abdallah, Sami M. Alshakhsheer, Salman B. Alosaimi, Ahmed R. Althmali, Solaiman A. Alahmari
General Public Knowledge, Preferred Dosage Forms, And Beliefs Toward Medicines In Western Saudi Arabia, Mahmoud S. Alhaddad, Qasem M. Abdallah, Sami M. Alshakhsheer, Salman B. Alosaimi, Ahmed R. Althmali, Solaiman A. Alahmari
Saudi Medical Journal
OBJECTIVE: To measure general public knowledge, source of knowledge, preferred dosage forms, and beliefs toward medicines. METHODS: A cross-sectional study design using convenience-sampling technique was used. A pre-validated questionnaire was designed and distributed to the general public through face-to-face interviews. All data were analyzed, and p-values less than 0.05 were considered significant. The study took place in the Clinical Pharmacy Department, Taif University, Taif, Kingdom of Saudi Arabia between August 2012 and February 2013 RESULTS: Nine hundred participants successfully responded to this study. Males represented two-thirds of the respondents (66.8%). In addition, 52% of respondents were of high education level. …
Systemic Lupus Erythematosus In Arab Children. Differences And Similarities With Different Ethnicities, Ashwaq A. Ale’Ed, Sulaiman M. Al-Mayouf
Systemic Lupus Erythematosus In Arab Children. Differences And Similarities With Different Ethnicities, Ashwaq A. Ale’Ed, Sulaiman M. Al-Mayouf
Saudi Medical Journal
OBJECTIVE: To describe systemic lupus erythematosus (SLE) features among Arab children, and compare with cohorts from different ethnicities. METHODS: This retrospective analysis of all published English literature on SLE in Arab children was conducted in March 2013. The percentage and frequencies of the clinical and laboratory features were collected, and compared between different Arab countries as well as Caucasian and South East Asian cohorts. RESULTS: A total of 560 children from 5 Arab cohorts with an average age at diagnosis of 10 years; 7.7% of patients were diagnosed before the age of 5 years. Familial SLE was frequent. Most patients …
Chemotherapy-Induced Febrile Neutropenia In Patients With Breast Cancer. A Multivariate Risk Assessment Model For First Cycle Chemotherapy, Sara S. Baghlaf, Abdulrhman A. Abulaban, Mohammed B. Abrar, Ahmed S. Al-Shehri
Chemotherapy-Induced Febrile Neutropenia In Patients With Breast Cancer. A Multivariate Risk Assessment Model For First Cycle Chemotherapy, Sara S. Baghlaf, Abdulrhman A. Abulaban, Mohammed B. Abrar, Ahmed S. Al-Shehri
Saudi Medical Journal
OBJECTIVE: To identify factors that increase the risk of developing febrile neutropenia (FN) during the first cycle of chemotherapy in breast cancer patients. METHODS: In this retrospective study, we reviewed the records of 211 patients with confirmed breast cancer treated with chemotherapy at the Princess Norah Oncology Center, King Abdulaziz Medical City, Jeddah, Kingdom of Saudi Arabia between January 2010 and May 2012. Statistical analysis was conducted using descriptive analysis, univariate, and multivariate logistic regressions. A multivariate regression of FN occurrence in the first cycle was developed. RESULTS: The median age of patients was 48 years. Febrile neutropenia was documented …
Dermatological Manifestations Of Hepatitis C Virus Infection In Saudi Arabia, Mona R. Halawani
Dermatological Manifestations Of Hepatitis C Virus Infection In Saudi Arabia, Mona R. Halawani
Saudi Medical Journal
The Saudi Ministry of Health data indicates that almost 32% of viral hepatitis cases were caused by hepatitis C virus (HCV). It has been widely reported that chronic HCV infection is associated with and may trigger or exacerbate many skin manifestations in 20-40% of patients visiting dermatologists. The most commonly encountered dermatological manifestations of HCV infection globally include mixed cryoglobulinemia, porphyria cutanea tarda, cutaneous and/or oral lichen planus, urticaria, pruritus, thrombocytopenic purpura, and psoriasis. The current article indicates that HCV infection is increasing in Saudi Arabia and approximately 12% of the reported dermatological manifestations are caused by HCV infection. We …
Increased Systemic Low-Grade Inflammation In High Altitude Native Rats Mediated By Adrenergic Receptors, Fahaid H. Al-Hashem, Abdullah S. Assiri, Abdullah S. Shatoor, Hesham M. Elrefaey, Riyad M. Alessa, Mahmoud A. Alkhateeb
Increased Systemic Low-Grade Inflammation In High Altitude Native Rats Mediated By Adrenergic Receptors, Fahaid H. Al-Hashem, Abdullah S. Assiri, Abdullah S. Shatoor, Hesham M. Elrefaey, Riyad M. Alessa, Mahmoud A. Alkhateeb
Saudi Medical Journal
OBJECTIVE: To compare the serum levels of inflammatory mediators in high altitude (HA) native rats, and to search for the possible underlying mechanism(s). METHODS: The study was carried out between January and April 2013. Fifty male rats from the same genetic pool were bred at either a HA or low altitude (LA) area. The study was carried out in 2 stages. In the first stage, serum levels of inflammatory markers, adhesive molecules, lipid profiles, catecholamines, magnesium (Mg+2), and lipid peroxidation were compared between theses 2 groups. In the second stages, inflammatory response and lipid peroxidation were analyzed in HA native …
Transient Elastography In Hepatitis B Virus Infection. Liver Stiffness Discrepancy Due To Sampling Location, Ting Wu, Lan Li, Hongwu Wang, Xiaoping Luo, Qin Ning
Transient Elastography In Hepatitis B Virus Infection. Liver Stiffness Discrepancy Due To Sampling Location, Ting Wu, Lan Li, Hongwu Wang, Xiaoping Luo, Qin Ning
Saudi Medical Journal
OBJECTIVE: To investigate the variability in liver stiffness (LS), measured by transient elastography, and determine the possible influencing factors in hepatitis B virus infection. METHODS: This cross-sectional study was conducted at the Department of Infectious Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China from March to June 2010. Three successful measurements at different sites in 123 patients were obtained, and the LS discrepancy was calculated. The influence of clinical data on the discrepancy was also assessed. RESULTS: The LS discrepancy was 1.3 (0.2-16.5) kPa and independently increased with a fibrosis stage: 0.9 …
Do Not Resuscitate Orders In A Saudi Pediatric Intensive Care Unit, Tareq Al-Ayed, Nabil Rahmo
Do Not Resuscitate Orders In A Saudi Pediatric Intensive Care Unit, Tareq Al-Ayed, Nabil Rahmo
Saudi Medical Journal
OBJECTIVE: To determine the percentage of deaths in the pediatric intensive care unit (PICU) attributed to do not resuscitate (DNR) orders, and to compare our DNR practice with the international experience. METHODS: Retrospective chart review of all children less than 14 years of age who died in the PICU at King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia from January 2007 to June 2009 (n=154). RESULTS: The main mode of death was attributed to DNR orders in 79 cases (51%), failed cardiopulmonary resuscitation in 60 cases (39%), and brain death in 15 cases (10%). Of the 79 DNR …
Infants Of Diabetic Mothers. A Cohort Study, Abeer E. Lasheen, Omer B. Abdelbasit, Mohammed Z. Seidahmed, Khalid A. Hussein, Abeer M. Miqdad, Gehan M. Farid, Haitham A. Badr
Infants Of Diabetic Mothers. A Cohort Study, Abeer E. Lasheen, Omer B. Abdelbasit, Mohammed Z. Seidahmed, Khalid A. Hussein, Abeer M. Miqdad, Gehan M. Farid, Haitham A. Badr
Saudi Medical Journal
OBJECTIVE: To determine the outcome of infants born to diabetic mothers at Security Forces Hospital, Riyadh, Saudi Arabia, and compare the complications seen in these infants with infants of non-diabetic mothers. METHODS: This is a concurrent prospective cohort study of a population of newborn infants delivered at Security Forces Hospital, Riyadh, Saudi Arabia for diabetic mothers between January 2011 and November 2011. RESULTS: A total of 601 infants were enrolled in the study consisting of 319 infants of non-diabetic mothers, and 282 infants of diabetic mothers. Infants of diabetic mothers showed significantly higher rates of associated complications and prolonged hospital …
Smoking Habits And Cessation Success. What Differs Among Adults And Elderly?, Turkan Gunay, Ozlem Pekel, Hatice Simsek, Ceyda Sahan, Ahmet Soysal, Oguz Kilinc, Gul Ergor
Smoking Habits And Cessation Success. What Differs Among Adults And Elderly?, Turkan Gunay, Ozlem Pekel, Hatice Simsek, Ceyda Sahan, Ahmet Soysal, Oguz Kilinc, Gul Ergor
Saudi Medical Journal
OBJECTIVE: To determine factors affecting smoking cessation success in different age groups. METHODS: This was an intervention study consisting of 761 patients attending the Balcova Municipality, Smoke Cessation Center, Izmir, Turkey, between November 2009 and December 2011. Variables were successful smoking cessation for one year, socio-demographic features, previous attempts at smoking cessation, a smoking spouse, nicotine dependency level, risk of depression, method of smoking cessation, presence of chronic disease, and decreasing smoking in the last year. Data was analyzed by logistic regression. RESULTS: Approximately 43.8% of the elderly, and 62.7% of the adults reduced the number of cigarettes smoked in …
Early Prevention Of Childhood Caries With Maternal Xylitol Consumption, Najlaa M. Alamoudi, Azza G. Hanno, Abdullah S. Almushayt, Mohammad I. Masoud
Early Prevention Of Childhood Caries With Maternal Xylitol Consumption, Najlaa M. Alamoudi, Azza G. Hanno, Abdullah S. Almushayt, Mohammad I. Masoud
Saudi Medical Journal
OBJECTIVE: To evaluate the effect of maternal xylitol consumption on children9s salivary mutans streptococci (MS) level, caries activity, and plaque accumulation in contrast with maternal fluoride varnish in a group of mother-child pairs. METHODS: In this randomized controlled trial, the study subjects were 60 mother-child pairs recruited from the pediatric dentistry clinic and the hospital well baby clinic at King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia. The sample was recruited on the basis of maternal high salivary MS levels, and a child aged 10-36 months. The subjects were randomly assigned to experimental and control groups. Mothers in the experimental …
Selenium Levels In Rice Samples From High And Low Risk Areas For Esophageal Cancer, Hadi Rahimzadeh-Barzoki, Hamidreza Joshaghani, Somayeh Beirami, Morteza Mansurian, Shahryar Semnani, Gholamreza Roshandel
Selenium Levels In Rice Samples From High And Low Risk Areas For Esophageal Cancer, Hadi Rahimzadeh-Barzoki, Hamidreza Joshaghani, Somayeh Beirami, Morteza Mansurian, Shahryar Semnani, Gholamreza Roshandel
Saudi Medical Journal
OBJECTIVE: To assess the relationship between selenium (Se) concentration in rice and the incidence of esophageal cancer (EC) in a high risk area in Northern Iran. METHODS: This ecological study was conducted in Golestan province of Iran in 2012. In this area, 45714 acres of land are cultivated by rice. A total of 69 rice samples were taken. We investigated Se concentrations by the voltammetric method. Statistical analysis was performed using the Pearson correlation test and Mann-Whitney U test. RESULTS: The mean (+/-SD) Se level in rice samples was 0.229 (+/-0.145) mg/kg. The Se concentration was significantly higher in rice …
Bariatric Surgery. Its Role In ‘Curing’ Diabetes, Faris F. Matloub
Bariatric Surgery. Its Role In ‘Curing’ Diabetes, Faris F. Matloub
Saudi Medical Journal
No abstract provided.
Hodgkin's Lymphoma. An Immunohistochemical Profile In Northern Iraq, Mustafa S. Fadhil, Wahda M. Al-Nueimy, Ahmad F. Lazim
Hodgkin's Lymphoma. An Immunohistochemical Profile In Northern Iraq, Mustafa S. Fadhil, Wahda M. Al-Nueimy, Ahmad F. Lazim
Saudi Medical Journal
OBJECTIVE: To evaluate the expression of several immunohistochemical markers in Hodgkin9s lymphoma (HL), and to determine the relative frequency of HL subtypes. METHODS: From January 2010 through January 2013, 42 HL cases were included in this case series study. Cases were collected from Al-Jumhori Teaching Hospital and private laboratories in Nineveh province, Iraq. The tumors were subtyped according to the World Health Organization classification system. Several markers including CD30, CD15, CD20, CD79a, CD3, and CD43 were evaluated immunohistochemically. RESULTS: The patients9 ages ranged from 5-81 years (mean: 32). A bimodal age distribution was discerned, with most cases in the third …
Perception Of Pain And Discomfort From Elastomeric Separators In Saudi Adolescents, Moshabab A. Asiry, Sahar F. Albarakati, Marwah S. Al-Marwan, Rana R. Al-Shammari
Perception Of Pain And Discomfort From Elastomeric Separators In Saudi Adolescents, Moshabab A. Asiry, Sahar F. Albarakati, Marwah S. Al-Marwan, Rana R. Al-Shammari
Saudi Medical Journal
OBJECTIVE: To examine the patient9s perception of pain and discomfort following the placement of elastomeric separators in Saudi adolescents. METHODS: The study was conducted on 38 adolescent patients who received fixed orthodontic treatment. The data was collected through the use of a self-administrated questionnaire that was distributed to the patients by one investigator in a non-clinical setting. The evaluation of pain started from the fourth hour after placement of elastomeric separators, and continued until the fifth day. RESULTS: The data showed that after 4 hours from separator placement, 94.7% of patients reported pain. There was a daily decrease in these …
Impact Of Transurethral Resection On Urinary Flow Rate In Children With Posterior Urethral Valve In Short Term Follow-Up, Tumay Ipekci, Yigit Akin, Hakan Gulmez, Erhan Ates, Selcuk Yucel
Impact Of Transurethral Resection On Urinary Flow Rate In Children With Posterior Urethral Valve In Short Term Follow-Up, Tumay Ipekci, Yigit Akin, Hakan Gulmez, Erhan Ates, Selcuk Yucel
Saudi Medical Journal
OBJECTIVE: To evaluate the correction rate of urinary flow rate after posterior urethral valve (PUV) resection for predicting success after operation. METHODS: This retrospective study was performed between March 2006 and February 2013 at the Department of Pediatric Urology, Akdeniz University School of Medicine, Antalya, Turkey. Of the 67 patients with PUV, 52 patients were enrolled. Physical examinations, urine and blood analyses, uroflowmetry (UFM) including maximum flow rate (Qmax) and average flow rate (Qavg), and post voiding residual urine volume (PVR) were recoded. The UFM, PVR, voiding cystourethrography, serum creatinine levels were recorded in clinical visits. Additional operations were performed …
Neutrophil/Lymphocyte And C-Reactive Protein/Mean Platelet Volume Ratios In Differentiating Between Viral And Bacterial Pneumonias And Diagnosing Early Complications In Children, Mervan Bekdas, Sevil B. Goksugur, Esma G. Sarac, Mustafa Erkocoglu, Fatih Demircioglu
Neutrophil/Lymphocyte And C-Reactive Protein/Mean Platelet Volume Ratios In Differentiating Between Viral And Bacterial Pneumonias And Diagnosing Early Complications In Children, Mervan Bekdas, Sevil B. Goksugur, Esma G. Sarac, Mustafa Erkocoglu, Fatih Demircioglu
Saudi Medical Journal
OBJECTIVE: To test the usability of neutrophil/lymphocyte (N/L) and C-reactive protein/mean platelet volume (CRP/MPV) ratios for the differential diagnosis of bacterial versus viral pneumonia, and the early diagnosis of complications related to pneumonia. METHODS: This retrospective study was conducted on 31 patients diagnosed with bacterial pneumonia and 21 patients diagnosed with viral pneumonia from January 2011 to December 2012 in the Department of Pediatrics, Faculty of Medicine, Abant Izzet Baysal University, Bolu, Turkey. We investigated the clinical characteristics, radiological, and laboratory findings of patients from their medical records. RESULTS: The female/male ratio of patients with bacterial was 1.0/1.8, and with …
Fetal Outcomes In Pregnant Women With Sickle Cell Disease, Sharifa H. Al-Farsi, Murtadha K. Al-Khabori, Mohammed N. Al-Hunieni, Nihal M. Al-Riyami
Fetal Outcomes In Pregnant Women With Sickle Cell Disease, Sharifa H. Al-Farsi, Murtadha K. Al-Khabori, Mohammed N. Al-Hunieni, Nihal M. Al-Riyami
Saudi Medical Journal
OBJECTIVE: To investigate fetal outcomes in pregnant women with sickle cell disease (SCD), and to analyze the impact of baseline variables on those outcomes. METHODS: This is a retrospective cohort study carried out over 5 years (June 2006 to August 2011) investigating fetal outcomes at Sultan Qaboos University Hospital, Muscat, Oman. Sixty-eight consecutive pregnant women with SCD (62 women with hemoglobin sickle cell anemia [SS] genotype) were included and analyzed in the study. Multivariable logistic regression was used to estimate the impact of baseline variables on major fetal complications (intrauterine growth restriction, intrauterine fetal death, and low birth weight babies, …
Effects Of Pregnancy On Sexual Function. Findings From A Survey Of Saudi Women, Sharifa A. Alsibiani
Effects Of Pregnancy On Sexual Function. Findings From A Survey Of Saudi Women, Sharifa A. Alsibiani
Saudi Medical Journal
OBJECTIVE: To assess sexual function during pregnancy in Saudi women. METHODS: We recruited 454 sexually active Saudi women (221 pregnant women, and 233 non-pregnant women) from the antenatal and gynecological clinics of King Abdulaziz University Hospital in Jeddah, Saudi Arabia, a tertiary referral university hospital, between May and October 2011. Participants were asked to complete an Arabic version of the Female Sexual Function Index (FSFI) questionnaire. This questionnaire assesses all the major domains of sexual dysfunction: desire, arousal, lubrication, orgasm, satisfaction, and pain. The overall FSFI scores, and those for each domain, were calculated for the pregnant and non-pregnant women. …
Healthy Lifestyle Among Primary Health Care Professionals, Mohammed A. Alateeq, Saleem M. Alarawi
Healthy Lifestyle Among Primary Health Care Professionals, Mohammed A. Alateeq, Saleem M. Alarawi
Saudi Medical Journal
OBJECTIVE: To assess 4 main determinants of healthy lifestyle (smoking, diet, physical activity, and body mass index) among primary health care professionals. METHODS: A cross-sectional study was carried out between December 2012 and February 2013 where participants were selected using a stratified-random sampling method from 4 primary care centers in King Abdulaziz Medical City, National Guard Health Affairs, Riyadh, Kingdom of Saudi Arabia. A trained nurse used an approved questionnaire for data collection. RESULTS: The study included 322 participants from different health professions in 4 family medicine centers. The prevalence of smoking was 8.4%. Most of the participants (75.1%) scored …
Natal And Neonatal Teeth, Deema J. Farsi, Muhammad M. Ahmed
Natal And Neonatal Teeth, Deema J. Farsi, Muhammad M. Ahmed
Saudi Medical Journal
Natal teeth (teeth present at birth) and neonatal teeth (teeth observed in the first 30 days of life) are uncommon. They may cause feeding problems and ulcerations on the ventral surface of the tongue. They can also be alarming to parents and cause discomfort with breastfeeding. A review of literature was conducted to review their etiology, significance, and clinical features with special emphasis on the complications and management. The opportunity of establishing a dental home through the early dental visits was highlighted. Furthermore, this case report details the examination and management of a 24-hour old neonate with 2 neonatal teeth. …
A Rare Case Of Fever Of Unknown Origin. Idiopathic Granulomatous Hepatitis, Esra Ekiz, Yasar Colak, Ilyas Tuncer
A Rare Case Of Fever Of Unknown Origin. Idiopathic Granulomatous Hepatitis, Esra Ekiz, Yasar Colak, Ilyas Tuncer
Saudi Medical Journal
No abstract provided.
Study Of The Correlationship Link Between Micrornas And Nasopharyngeal Carcinoma, Xin-Hua Xu, Yang Liu
Study Of The Correlationship Link Between Micrornas And Nasopharyngeal Carcinoma, Xin-Hua Xu, Yang Liu
Saudi Medical Journal
Nasopharyngeal carcinoma (NPC) is a polygenic disease related to a variety of factors. With the development of the microRNAs (miRNAs) technique, researchers found a close link between miRNAs and NPC. Differentially expressed miRNAs exist in NPC and normal nasopharyngeal tissues; radiotherapy and chemotherapy also affect the expression of miRNAs in NPC tissues. Further studies showed that dysregulation and ectopic expression of miRNAs were involved in the occurrence and development of NPC by affecting the expression of oncogenes or tumor suppressor genes, or acting on relevant signal transduction pathways. It is of great significance to investigate the miRNAs related to the …
Immune Responses Against Mycobacterium Tuberculosis-Specific Proteins Pe35 And Cfp10 In Mice Immunized With Recombinant Mycobacterium Vaccae, Hanady A. Amoudy, Belghies H. Ebrahimi, Abu S. Mustafa
Immune Responses Against Mycobacterium Tuberculosis-Specific Proteins Pe35 And Cfp10 In Mice Immunized With Recombinant Mycobacterium Vaccae, Hanady A. Amoudy, Belghies H. Ebrahimi, Abu S. Mustafa
Saudi Medical Journal
OBJECTIVE: To clone and express Mycobacterium tuberculosis (M. tuberculosis) proteins PE35 and culture filtrate protein (CFP)10 in Mycobacterium vaccae (M. vaccae), and subsequently, evaluate the humoral and cellular immunity responses against these recombinant constructs in mice. METHODS: The DNA of PE35 and CFP 10 genes were cloned into the shuttle plasmid pDE22, and the recombinant plasmids were electroporated into M. vaccae. The recombinant constructs were then tested for expression of PE35 and CFP10 by Western immunoblotting using rabbit anti-sera. Furthermore, splenocytes and sera from groups of 5 mice immunized with recombinant M. vaccae (rVaccae) were tested for cellular and humoral …
Is Vesicolithotomy With Bladder Wash The Answer For Rectovesical Fistula Secondary To Neglected Vesical Stone? Complicated Presentation But Simple Management, Abdellatif K. Elnaim, Mamoun M. Mohamed
Is Vesicolithotomy With Bladder Wash The Answer For Rectovesical Fistula Secondary To Neglected Vesical Stone? Complicated Presentation But Simple Management, Abdellatif K. Elnaim, Mamoun M. Mohamed
Saudi Medical Journal
It is extremely rare that the urinary bladder stones cause vesicorectal fistulas. Urinary tract infection and poor fluid intake are the main etiologies that precipitate vesical stone formation, and subsequent rectovesical fistula. We present a complicated case of neglected vesical stone, which recurred 3 times. The patient presented with passage of urine per rectum leading to fecal incontinence. He was managed only with vesicolithotomy and bladder wash with eventual spontaneous closure of the rectovesical fistula.
Specific Anti-Gastric Cancer Effects Of A Recombinant Plasmid Expressing Nonstructural Protein 1 Of Parvovirus H1, Di Zhao, Chenwen Cai, Yuanyuan Wang, Shudong Xiao, Qing Zheng
Specific Anti-Gastric Cancer Effects Of A Recombinant Plasmid Expressing Nonstructural Protein 1 Of Parvovirus H1, Di Zhao, Chenwen Cai, Yuanyuan Wang, Shudong Xiao, Qing Zheng
Saudi Medical Journal
OBJECTIVE: To investigate the responsiveness of gastric tumor cells to the nonstructural protein (NS)1 of parvovirus H1, which has a preferential lytic growth cycle in cancer cells. METHODS: This study was carried out in Shanghai Institute of Digestive Disease, Renji Hospital, Shanghai, China from 2009 to 2012. An NS1-expressing plasmid was introduced into gastric cell lines or nude mice bearing tumor grafts. Expression was monitored by tracking fluorescence tag and specific transcription. Tumor growth suppression was measured, and cell cycle dyshomeostasis was verified by flow cytometry. Cell cycle regulators9 level was measured on both the transcription and protein level. RESULTS: …