Digital Commons Network^™

Digestibility Of Wheat Alpha-Amylase/Trypsin Inhibitors Using A Caricain Digestive Supplement, Angéla Juhász, Mitchell G. Nye-Wood, Gregory J. Tanner, Michelle L. Colgrave

Research outputs 2022 to 2026

Wheat is a major source of nutrition, though in susceptible people it can elicit inappropriate immune responses. Wheat allergy and non-celiac wheat sensitivity are caused by various wheat proteins, including alpha-amylase trypsin inhibitors (ATIs). These proteins, like the gluten proteins which can cause celiac disease, are incompletely digested in the stomach such that immunogenic epitopes reach the lower digestive system where they elicit the undesirable immune response. The only completely effective treatment for these immune reactions is to eliminate the food trigger from the diet, though inadvertent or accidental consumption can still cause debilitating symptoms in susceptible people. One approach …

A Novel Prognostic 7-Methylguanosine Signature Reflects Immune Microenvironment And Alternative Splicing In Glioma Based On Multi-Omics Analysis, Zihan Wang, Zhiwei Zhong, Zehua Jiang, Zepeng Chen, Yuequn Chen, Yimin Xu

Research outputs 2022 to 2026

Glioma is the most common type of central nervous system tumor with increasing incidence. 7-methylguanosine (m7G) is one of the diverse RNA modifications that is known to regulate RNA metabolism and its dysregulation was associated with various cancers. However, the expression pattern of m7G regulators and their roles in regulating tumor immune microenvironments (TIMEs) as well as alternative splicing events (ASEs) in glioma has not been reported. In this study, we showed that m7G regulators displayed a close correlation with each other and most of them were differentially expressed between normal and glioma tissues. Two m7G signatures were then constructed …

An Analysis Of Whether Privately Owned Financial Planning Practices Are Transitioning To Fully Independent Advice Providers, Darren Pawski, Robert Powell, Anna Golab

Research outputs 2022 to 2026

In Australia, there are over 20,000 financial advisers, with only 1 % registered as independent financial advisers. This study investigates why there has been no significant transition to independent advising. The importance of the study is underlined by the substantial losses suffered by thousands of consumers from advice that has been found to be influenced by conflicts of interest. Using a qualitative technique, the study undertook exploratory semi-structured interviews among financial advisers. The study found that over 90% of privately owned advisers will not be transitioning to independent advising due to the belief that clients will not pay fees for …

Determining Factors In Graduate Recruitment And Preparing Students For Success, Denise Jackson, Linda Riebe, Flavio Macau

Research outputs 2022 to 2026

Purpose: This study aims to investigate graduate employer perceptions of determining factors in recruitment decisions and their preferred use of recruitment channels. This study drew on the employability capitals model to interpret findings and identify ways to better prepare higher education students for recruitment and selection. This is particularly important in declining graduate labour markets, further weakened by COVID-19. Design/methodology/approach: This study gathered data from surveying 183 Australian employers from different organisational settings. Responses were analysed using descriptive and multivariate techniques, the latter exploring variations by role type, sector and organisation size. Findings: Findings reaffirmed the criticality of students having …

Lipopolysaccharide-Induced Interferon Response Networks At Birth Are Predictive Of Severe Viral Lower Respiratory Infections In The First Year Of Life, James F. Read, Michael Serralha, Danny Mok, Barbara J. Holt, Mark Cruickshank, Yuliya V. Karpievitch, David I. Broadhurst, Peter D. Sly, Deborah H. Strickland, Stacey N. Reinke, Patrick G. Holt, Anthony Bosco

Research outputs 2022 to 2026

Appropriate innate immune function is essential to limit pathogenesis and severity of severe lower respiratory infections (sLRI) during infancy, a leading cause of hospitalization and risk factor for subsequent asthma in this age group. Employing a systems biology approach to analysis of multi-omic profiles generated from a high-risk cohort (n = 50), we found that the intensity of activation of an LPS-induced interferon gene network at birth was predictive of sLRI risk in infancy (AUC = 0.724). Connectivity patterns within this network were stronger among susceptible individuals, and a systems biology approach identified IRF1 as a putative master regulator of …

Consensus Head Acceleration Measurement Practices (Champ): Origins, Methods, Transparency And Disclosure, Kristy B. Arbogast, Jaclyn B. Caccese, Thomas A. Buckley, Andrew S. Mcintosh, Kyvory Henderson, Brian D. Stemper, Gary Solomon, Steven P. Broglio, James R. Funk, Jeff R. Crandall

Research outputs 2022 to 2026

The use of head kinematic measurement devices has recently proliferated owing to technology advances that make such measurement more feasible. In parallel, demand to understand the biomechanics of head impacts and injury in sports and the military has increased as the burden of such loading on the brain has received focused attention. As a result, the field has matured to the point of needing methodological guidelines to improve the rigor and consistency of research and reduce the risk of scientific bias. To this end, a diverse group of scientists undertook a comprehensive effort to define current best practices in head …

New Technology And Desired Skills Of Early Career Accountants, Denise Jackson, Grant Michelson, Rahat Munir

Research outputs 2022 to 2026

Purpose: Technological advances have led to accounting roles shifting from transaction focussed tasks to using data generated by technology to inform stakeholder strategies, resulting in changing skill requirements. This study aims to investigate how early career accountants (ECAs) and organisations value different skills among ECAs, how technology is impacting on these skills and the preparedness of ECAs for future technological work in different organisational settings.

Design/methodology/approach: The research adopted a multi-stakeholder, mixed-method approach, surveying 315 ECAs and 175 managers/recruiters and interviewing 10 from each group. The sample drew from different industry sectors and organisation types in Australia, with all states …

Guidelines For Model Adaptation: A Study Of The Transferability Of A General Seagrass Ecosystem Dynamic Bayesian Networks Model, Paula Sobenko Hatum, Kathryn Mcmahon, Kerrie Mengersen, Paul Pao Yen Wu

Research outputs 2022 to 2026

In general, it is not feasible to collect enough empirical data to capture the entire range of processes that define a complex system, either intrinsically or when viewing the system from a different geographical or temporal perspective. In this context, an alternative approach is to consider model transferability, which is the act of translating a model built for one environment to another less well-known situation. Model transferability and adaptability may be extremely beneficial—approaches that aid in the reuse and adaption of models, particularly for sites with limited data, would benefit from widespread model uptake. Besides the reduced effort required to …

The Effect Of Technology And Regulation On The Co-Evolution Of Product And Industry Architecture, Nicholas Burton, Peter Galvin

Research outputs 2022 to 2026

This paper explores the co-evolution of product and industry architecture by drawing on a longitudinal study of the UK personal pensions industry between 2005 and 2020. It provides qualitative evidence for the way in which institutional structures, particularly regulation, entwine with firm strategic choices to shape the contours of an industry value chain (IVC). We draw upon modularity theory and the literature on industry architecture to consider how strategic bottlenecks emerged and how value shifted between layers of the IVC. Furthermore, we examine the interplay between the agendas of the regulator and firm strategic responses to unpack how firms (product …

Prevalence Of Suspected Poor Bone Health In People With Chronic Obstructive Pulmonary Disease - A Cross-Sectional Exploratory Study, Erin Cecins, Vinicius Cavalheri, Dennis R. Taaffe, Anne Marie Hill, Sarah Hug, Kylie Hill

Research outputs 2022 to 2026

Background: Compared to the general population, adults with chronic obstructive pulmonary disease (COPD) have an increased prevalence of osteoporosis. Despite the known risk factors and potential complications of compromised bone health in COPD, little is known about whether poor bone health is routinely suspected. We measured, in people with COPD, the prevalence of those who had one or more indicators suggestive of suspected poor bone health, and compared the characteristics of those with versus without these indicators. Methods: Data were collected from adults with COPD presenting to three tertiary hospitals. Indicators of suspected poor bone health were defined as any …

Application Of Underbalanced Tubing Conveyed Perforation In Horizontal Wells: A Case Study Of Perforation Optimization In A Giant Oil Field In Southwest Iran, Erfan Mohammadian, Milad Ebrahimi Dastgerdi, Abbas Khaksar Manshad, Amir H. Mohammadi, Bo Liu, Stefan Iglauer, Alireza Keshavarz

Research outputs 2022 to 2026

Underbalanced perforation can substantially reduce formation damage and improve the efficiency of production operation. The field in question is a giant oil field in Southwest Iran, with over 350,000 bbl/day production rates. Reservoir X is the main reservoir of the field and includes 139 horizontal wells out of the total of 185 production wells drilled in the field. Despite its technical difficulties, under-balance perforation has been proven to result in high productivity ratios and has been shown to reduce workover costs if appropriately conducted. Therefore, this study investigated a customized underbalanced tubing conveyed perforation to enhance oil production. First, post-drilling …

Progressive Resistance Training For Concomitant Increases In Muscle Strength And Bone Mineral Density In Older Adults: A Systematic Review And Meta-Analysis, Steven J. O’Bryan, Catherine Giuliano, Mary N. Woessner, Sara Vogrin, Cassandra Smith, Gustavo Duque, Itamar Levinger

Research outputs 2022 to 2026

Background:

Older adults experience considerable muscle and bone loss that are closely interconnected. The efficacy of progressive resistance training programs to concurrently reverse/slow the age-related decline in muscle strength and bone mineral density (BMD) in older adults remains unclear.

Objectives:

We aimed to quantify concomitant changes in lower-body muscle strength and BMD in older adults following a progressive resistance training program and to determine how these changes are influenced by mode (resistance only vs. combined resistance and weight-bearing exercises), frequency, volume, load, and program length.

Methods:

MEDLINE/PubMed and Embase databases were searched for articles published in English before 1 June, …

Thermodynamic Modeling Of Hydrogen–Water Systems With Gas Impurity At Various Conditions Using Cubic And Pc-Saft Equations Of State, Amer Alanazi, Saleh Bawazeer, Muhammad Ali, Alireza Keshavarz, Hussein Hoteit

Research outputs 2022 to 2026

Hydrogen (H2) has emerged as a viable solution for energy storage of renewable sources, supplying off-seasonal demand. Hydrogen contamination due to undesired mixing with other fluids during operations is a significant problem. Water contamination is a regular occurrence; therefore, an accurate prediction of H2-water thermodynamics is crucial for the design of efficient storage and water removal processes. In thermodynamic modeling, the Peng–Robinson (PR) and Soave Redlich–Kwong (SRK) equations of state (EoSs) are widely applied. However, both EoSs fail to predict the vapor-liquid equilibrium (VLE) accurately for H2-blend mixtures with or without fine-tuning binary interaction parameters due to the polarity of …

Investigating The Microstructural And Mechanical Properties Of Novel Ternary Reinforced Aa7075 Hybrid Metal Matrix Composite, Afnan Haider Khan, Syed Ahmad Ali Shah, Farheen Umar, Uneeb Noor, Rizwan Mahmood Gul, Khaled Giasin, Muhammad Aamir

Research outputs 2022 to 2026

This study investigates the comparison of the microstructural and mechanical properties of a novel ternary reinforced AA7075 hybrid metal matrix composite. Four samples, including AA7075 (base alloy), AA7075-5wt % SiC (MMC), AA7075-5wt %SiC-3wt % RHA (s-HMMC), and AA7075-5wt % SiC-3wt % RHA-1wt % CES (n-HMMC) were developed using the stir casting liquid metallurgy route, followed by the heat treatment. The experimental densities corresponded with the theoretical values, confirming the successful fabrication of the samples. A minimum density of 2714 kg/m3 was recorded for the n-HMMC. In addition, the highest porosity of 3.11 % was found for n-HMMC. Furthermore, an increase …

Saliva Cortisol Diurnal Variation And Stress Responses In Term And Preterm Infants, David Q. Stoye, James P. Boardman, Clive Osmond, Gemma Sullivan, Gillian Lamb, Gill S. Black, Natalie Z. M. Homer, Nina Nelson, Elvar Theodorsson, Evalotte Mörelius, Rebecca M. Reynolds

Research outputs 2022 to 2026

Objective:

To determine if preterm birth is associated with adaptation of the hypothalamic–pituitary–adrenal (HPA) axis and whether HPA axis programming relates to the degree of prematurity (defined as extremely preterm birth at < 28 weeks or very preterm birth at 28–32 weeks gestation).

Design:

This study reports findings from a prospective birth cohort. Saliva cortisol concentrations were measured prevaccination and postvaccination, and in the morning and evening, at 4 months chronological age.

Setting:

Infants born at a single Scottish hospital.

Participants:

45 term-born, 42 very preterm and 16 extremely preterm infants.

Outcomes:

Cortisol stress response to vaccination (postvaccination minus prevaccination cortisol concentrations), diurnal slope (log-transformed morning minus log-transformed evening cortisol values) …

Care Ethics Framework For Midwifery Practice: A Scoping Review, Kate Buchanan, Elizabeth Newnham, Deborah Ireson, Clare Davison, Sadie Geraghty

Research outputs 2022 to 2026

Background:

As a normative theory, care ethics has become widely theorized and accepted. However, there remains a lack of clarity in relation to its use in practice, and a care ethics framework for practice. Maternity care is fraught with ethical issues and care ethics may provide an avenue to enhance ethical sensitivity.

Aim:

The purpose of this scoping review is to determine how care ethics is used amongst health professions, and to collate the information in data charts to create a care ethics framework and definition for midwifery practice.

Method:

The scoping review was conducted according to the Preferred Reporting …

Lifetime Maximization In Underwater Wireless Communication Networks, Kazi Yasin Islam, Iftekhar Ahmad, Daryoush Habibi, Jiong Jin, Muhammad Waqas

Research outputs 2022 to 2026

The rise in demand for underwater wireless communication networks (UWCN) has been driven by the emergence of new applications including unmanned underwater vehicles, deep-sea exploration, maritime and underwater archaeology research, and diver communications. For various applications, underwater network lifetime must be long, since unlike terrestrial sensor networks, it is a major job to change/recharge node batteries in underwater environments. In this paper, we introduce a solution where critical nodes in a UWCN are periodically recharged by small renewable energy sources. Further, a caching mechanism is introduced to relieve critical nodes of heavy workload when their residual energies run low. By …

Deep Learning For Robust Adaptive Inverse Control Of Nonlinear Dynamic Systems: Improved Settling Time With An Autoencoder, Nuha A. S. Alwan, Zahir M. Hussain

Research outputs 2022 to 2026

An adaptive deep neural network is used in an inverse system identification setting to approximate the inverse of a nonlinear plant with the aim of constituting the plant controller by copying to the latter the weights and architecture of the converging deep neural network. This deep learning (DL) approach to the adaptive inverse control (AIC) problem is shown to outperform the adaptive filtering techniques and algorithms normally used in adaptive control, especially when in nonlinear plants. The deeper the controller, the better the inverse function approximation, provided that the nonlinear plant has an inverse and that this inverse can be …

A Retrospective Study For Prognostic Significance Of Type Ii Diabetes Mellitus And Hemoglobin A1c Levels In Non-Small Cell Lung Cancer Patients Treated With Pembrolizumab, Yinchen Shen, Jiaqi Li, Huiping Qiang, Yuqiong Lei, Qing Chang, Runbo Zhong, Giulia Maria Stella, Francesco Gelsomino, Yeon Wook Kim, Afaf Abed, Jialin Qian, Tianqing Chu

Research outputs 2022 to 2026

Background:

Diabetes mellitus (DM) is common and recognized as a risk factor for developing non-small cell lung cancer (NSCLC) while the prognostic evaluation is still controversial. As immunotherapy is widely used in clinical practice, its efficacy and survival should be investigated in patients with DM.

Methods:

We retrospectively recruited 266 locally advanced and metastatic NSCLC patients who received pembrolizumab alone or in combination with chemotherapy. Patients' clinicopathological data, including age, history of DM, hemoglobin A1c (HbA1c), genetic tumor profiling, and survival data were collected. Associations between clinical characteristics and survival were evaluated by univariate and multivariate analyses.

Results:

In this …

Hla Pharmacogenetic Markers Of Drug Hypersensitivity From The Perspective Of The Populations Of The Greater Middle East, Hend Chaker Masmoudi, Nariman Afify, Halima Alnaqbi, Zainab Alhalwachi, Guan Kwang Tay, Habiba Alsafar

Research outputs 2022 to 2026

Specific HLA associations with drug hypersensitivity may vary between geographic regions and ethnic groups. There are little to no data related to HLA-drug hypersensitivity on populations who reside in the Greater Middle East (GME), a vast region spanning from Morocco in the west to Pakistan in the east. In this review, the authors intended to summarize the significant HLA alleles associated with hypersensitive drug reactions induced by different drugs, as have been found in different populations, and to summarize the prevalence of these alleles in the specific and diverse populations of the GME. For example, HLA-B * 57:01 allele prevalence, …

“I'M Not Batman” And Other Factors Impacting Bystander Intervention Against Sexual Violence In Australian Nightlife Settings, Aimee-Rose Wrightson-Hester, Alfred Allan, Maria M. Allan

Research outputs 2022 to 2026

Unsolicited sexual behaviors that constitute sexual violence appear to be commonplace in nightlife settings in many countries and bystander intervention might be a way to eliminate them. However, few researchers have investigated the barriers and facilitators that affect Australian bystanders’ likelihood to help, and these should be considered in the planning of bystander intervention programs. Using a grounded theory approach, we interviewed fourteen men and women about their perceptions of factors that might influence bystander behavior in Australian nightlife settings. The categories identified suggest that it is difficult for nightlife patrons to notice and identify sexual violence occurring around them. …

Determinants Of Blood Acylcarnitine Concentrations In Healthy Individuals Of The European Prospective Investigation Into Cancer And Nutrition, Roland Wedekind, Joseph A. Rothwell, Vivian Viallon, Pekka Keski-Rahkonen, Julie A. Schmidt, Veronique Chajes, Vna Katzke, Theron Johnson, Maria Santucci De Magistris, Vittorio Krogh, Pilar Amiano, Carlotta Sacerdote, Daniel Redondo-Sánchez, José María Huerta, Anne Tjønneland, Pratik Pokharel, Paula Jakszyn, Rosario Tumino, Eva Ardanaz, Torkjel M. Sandanger, Anna Winkvist, Johan Hultdin, Matthias B. Schulze, Elisabete Weiderpass, Marc J. Gunter, Inge Huybrechts

Research outputs 2022 to 2026

Background & aims: Circulating levels of acylcarnitines (ACs) have been associated with the risk of various diseases such as cancer and type 2 diabetes. Diet and lifestyle factors have been shown to influence AC concentrations but a better understanding of their biological, lifestyle and metabolic determinants is needed. Methods: Circulating ACs were measured in blood by targeted (15 ACs) and untargeted metabolomics (50 ACs) in 7770 and 395 healthy participants of the European Prospective Investigation into Cancer and Nutrition (EPIC), respectively. Associations with biological and lifestyle characteristics, dietary patterns, self-reported intake of individual foods, estimated intake of carnitine and fatty …

The Impact Of Holiday Tourism Development On Tourism Total Factor Productivity: Evidence From China, Panpan Sun, Songshan (Sam) Huang, Ghialy Yap

Research outputs 2022 to 2026

Tourism development during holiday periods may influence tourism total factor productivity (TTFP) in the industry. However, little is known about the impact of holiday tourism on TTFP. Focusing on China's Golden Week holiday system, this study applies dynamic panel models to test the effect of holiday tourism development on TTFP with panel data of 31 provinces in mainland China from 2001 to 2019. The study also compares the effects before and after 2008 when the Golden Week holiday system changed from three weeks to two weeks with shorter holiday breaks. Results show that holiday tourism development has a negative effect …

Reunification In Informal Foster Care Child Placement: Examining The Different Pathways In Ghana, Hajara Bentum, Esmeranda Manful

Research outputs 2022 to 2026

Informal foster care remains the preferred alternative care option for children in many parts of the world. However, the processes of reunification in informal foster care are largely unknown. This qualitative study sought to explore the reunification processes within informal foster care in Ghana to inform child protection services for better program design for such children. Twenty interviews were conducted with reunified fostered children and their biological parents. Data from the in-depth interviews with parents and children were analyzed thematically. Three main processes of reunification were identified in this study namely; open, flexible exit plans and educational threshold arrangements. The …

Assessment Of A Size-Based Method For Enriching Circulating Tumour Cells In Colorectal Cancer, Sai Shyam Vasantharajan, Edward Barnett, Elin S. Gray, John L. Mccall, Euan J. Rodger, Michael R. Eccles, Fran Munro, Sharon Pattison, Aniruddha Chatterjee

Research outputs 2022 to 2026

Circulating tumour cells (CTC) from solid tumours are a prerequisite for metastasis. Isolating CTCs and understanding their biology is essential for developing new clinical tests and precision oncology. Currently, CellSearch is the only FDA (U.S. Food and Drug Administration)-approved method for CTC enrichment but possesses several drawbacks owing to a reliance on the epithelial cell adhesion molecule (EpCAM) and a resource-intensive nature. Addressing these shortcomings, we optimised an existing size-based method, MetaCell, to enrich CTCs from blood of colorectal cancer (CRC) patients. We evaluated the ability of MetaCell to enrich CTCs by spiking blood with CRC cell lines and assessing …

Targeting Paleovalley-Related Ferricrete Units In Yilgarn Craton Using High-Resolution Aeromagnetic Data And Spatial Machine Learning, Hassan Talebi, Jelena Markov, Walid Salama, Alex Otto, Vasek Metelka, Ravi Anand, Dave Cole

Research outputs 2022 to 2026

The ferricrete units (Fe oxide cemented colluvial-alluvial sediment) of the Yilgarn Craton in Western Australia formed during the humid tropical and sub-tropical climates of the Cenozoic. Ferricretes are generally developed on long-lived paleodrainage systems and are products of the ferruginisation of detritus provided by the continuous erosion of upslopes. These iron-rich accumulations can become Au-enriched, as is the case in several locations previously discovered in the Yilgarn Craton; many of these host economic secondary gold deposits (e.g., Moolart Well, Mt Gibson, and Bulchina), typically occurring downslope of low saprolite hills and near paleovalleys (i.e., inset-valleys). Inset-valleys are a common paleotopographic …

Ransomware 2.0: An Emerging Threat To National Security, Mohiuddin Ahmed, Sascha Dominik Dov Bachmann, Abu Barkat Ullah, Shaun Barnett

Research outputs 2022 to 2026

The global Covid-19 pandemic has seen the rapid evolution of our traditional working environment; more people are working from home and the number of online meetings has increased. This trend has also affected the security sector. Consequently, the evolution of ransomware to what is now being described as ‘Ransomware 2.0’ has governments, businesses and individuals alike rushing to secure their data.

International Sports Diplomacy In Action–An Investigation Of Aus+Rally: An Australian Sports Diplomacy Campaign In Japan, Alexander R. Best, Ian Austin

Research outputs 2022 to 2026

As exercised by the recent Tokyo 2020 Olympics and 2020 Paralympics, both delayed until 2021 due to COVID-19 conditions, sports diplomacy is shifting, from emergence as a concept, toward empirical legitimacy. Extant literature has allowed scholars to clearly establish the factors constituting sports diplomacy, which has culminated in the sports diplomacy model proposed by Abdi and colleagues. This study examines the sports diplomacy model through a qualitative investigation of an operational Australian sports diplomacy campaign, AUS+RALLY, within the context of Japan. The evident conformity of the extant sports diplomacy model with the AUS+RALLY campaign represents an important step for sports …

Concurrent Exposure To (Acute Intermittent) Hypoxia And Hypercapnia: A Promising Therapeutic Cocktail For Neuroplasticity?, Ricardo N. O. Mesquita

Research outputs 2022 to 2026

Pioneering experiments revealed that intermittent stimulation of afferent neurons from the carotid bodies elicits long-lasting increased activity of respiratory nerves, a phenomenon known as respiratory long-term facilitation (LTF). Initially observed with episodic electrical stimulation of the carotid sinus nerve, this phenomenon was then extensively demonstrated in rodent experiments via protocols of brief, episodic exposures to periods of hypoxia (i.e. acute intermittent hypoxia; AIH). Then, the realization that AIH could be used as a therapeutic modality to induce neuroplasticity and restore both respiratory and non-respiratory motor function in rats with spinal cord injuries (SCI) motivated translation to human studies. AIH has …

Appropriateness Of Indirect Markers Of Muscle Damage Following Lower Limbs Eccentric-Biased Exercises: A Systematic Review With Meta-Analysis, Emeric Chalchat, Anne Fleur Gaston, Keyne Charlot, Luis Peñailillo, Omar Valdés, Pierre Emmanuel Tardo-Dino, Kazunori Nosaka, Vincent Martin, Sebastian Garcia-Vicencio, Julien Siracusa

Research outputs 2022 to 2026

Purpose The aim of this review was to (1) characterize the time-course of markers of exercise-induced muscle damage (EIMD) based on the level of maximal voluntary contraction torque loss at 24-48h post-exercise (MVCloss24-48h), (2) identify factors (e.g., exercise and population characteristics) affecting the level of MVCloss24-48h, and (3) evaluate the appropriateness of EIMD markers as indicators of MVCloss24-48h. Methods Magnitude of change of each EIMD markers was normalized using the standardized mean differences method to compare the results from different studies. Time-course of EIMD markers were characterized according to three levels of MVCloss24-48h based on a clustering analysis of the …