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Research outputs 2022 to 2026

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Efficacy And Safety Of Acupuncture And Or Moxibustion For Managing Primary Dysmenorrhea: A Systematic Review And Meta-Analysis, Weiting Liu, Carol Chunfeng Wang, Khui Hung Lee, Xiaopeng Ma, Timothy Leen Kang Sep 2022

Efficacy And Safety Of Acupuncture And Or Moxibustion For Managing Primary Dysmenorrhea: A Systematic Review And Meta-Analysis, Weiting Liu, Carol Chunfeng Wang, Khui Hung Lee, Xiaopeng Ma, Timothy Leen Kang

Research outputs 2022 to 2026

Acupuncture and moxibustion have been accepted as add-on options for primary dysmenorrhea (PD); however, the clinical evidence is still inadequate. We searched AMED, CENTRAL, EMBASE, PubMed, Web of Science, CBM, CNKI, VIP, Wangfang database, ANZCTR, ClinicalTrials.gov, and the WHO ICTRP, from their inception to February 2021. The pooled analysis of 13 RCTs with 675 participants for VAS showed that acupuncture and moxibustion were more effective in managing PD than the control group with the MD of −1.93 (95% CI [−2.80, −1.06] and −2.67 (95% CI [−4.96, −0.38]). With the CMSS, seven studies with 487 participants showed that these modalities were …


Systemic Perturbations Of The Kynurenine Pathway Precede Progression To Dementia Independently Of Amyloid-Β, Marcela Cespedes, Kelly R. Jacobs, Paul Maruff, Alan Rembach, Christopher J. Fowler, Brett Trounson, Kelly K. Pertile, Rebecca L. Rumble, Stephanie R. Rainey-Smith, Christopher C. Rowe, Victor L. Villemagne, Pierrick Bourgeat, Chai K. Lim, Pratishtha Chatterjee, Ralph N. Martins, Arne Ittner, Colin L. Masters, James D. Doecke, Gilles J. Guillemin, David B. Lovejoy Sep 2022

Systemic Perturbations Of The Kynurenine Pathway Precede Progression To Dementia Independently Of Amyloid-Β, Marcela Cespedes, Kelly R. Jacobs, Paul Maruff, Alan Rembach, Christopher J. Fowler, Brett Trounson, Kelly K. Pertile, Rebecca L. Rumble, Stephanie R. Rainey-Smith, Christopher C. Rowe, Victor L. Villemagne, Pierrick Bourgeat, Chai K. Lim, Pratishtha Chatterjee, Ralph N. Martins, Arne Ittner, Colin L. Masters, James D. Doecke, Gilles J. Guillemin, David B. Lovejoy

Research outputs 2022 to 2026

Increasing evidence suggests that kynurenine pathway (KP) dyshomeostasis may promote disease progression in dementia. Studies in Alzheimer's disease (AD) patients confirm KP dyshomeostasis in plasma and cerebrospinal fluid (CSF) which correlates with amyloid-β and tau pathology. Herein, we performed the first comprehensive study assessing baseline levels of KP metabolites in participants enrolling in the Australian Imaging Biomarkers Flagship Study of Aging. Our purpose was to test the hypothesis that changes in KP metabolites may be biomarkers of dementia processes that are largely silent. We used a cross-sectional analytical approach to assess non-progressors (N = 73); cognitively normal (CN) or mild …


Renewable And Recyclable Polymeric Materials For Food Packaging: A New Open Special Issue In Materials, Shima Jafarzadeh, Masoumeh Zargar, Mehrdad Forough Sep 2022

Renewable And Recyclable Polymeric Materials For Food Packaging: A New Open Special Issue In Materials, Shima Jafarzadeh, Masoumeh Zargar, Mehrdad Forough

Research outputs 2022 to 2026

“Renewable and Recyclable Polymeric Materials for Food Packaging” is a new open Special Issue of Materials that will publish original and review papers on new scientific and applied research, and the articles it contains will make a contribution to the discovery and understanding of biodegradable and recyclable materials, their functional properties, characterization and applications.


Moderate Increase Of Serum Uric Acid Within A Normal Range Is Associated With Improved Cognitive Function In A Non-Normotensive Population: A Nationally Representative Cohort Study, Jinqi Wang, Rui Jin, Zhiyuan Wu, Yueruijing Liu, Xiaohan Jin, Ze Han, Yue Liu, Zongkai Xu, Xiuhua Guo, Lixin Tao Sep 2022

Moderate Increase Of Serum Uric Acid Within A Normal Range Is Associated With Improved Cognitive Function In A Non-Normotensive Population: A Nationally Representative Cohort Study, Jinqi Wang, Rui Jin, Zhiyuan Wu, Yueruijing Liu, Xiaohan Jin, Ze Han, Yue Liu, Zongkai Xu, Xiuhua Guo, Lixin Tao

Research outputs 2022 to 2026

Background: Associations between serum uric acid (SUA) and changes in cognitive function are understudied in non-normotensive populations, and many previous studies only considered the baseline SUA at a single time point. We aimed to examine the effects of baseline SUA and 4-year changes in SUA on cognitive changes in the non-normotensive population. Materials and methods : In the China Health and Retirement Longitudinal Study (CHARLS), cognitive function was measured based on executive function and episodic memory in four visits (years: 2011, 2013, 2015, and 2018). We identified two study cohorts from CHARLS. The first cohort included 3,905 non-normotensive participants. Group-based …


Regeneration Time: Ancient Wisdom For Planetary Wellbeing, Anne Poelina, Sandra Wooltorton, Mindy Blaise, Catrina Luz Aniere, Pierre Horwitz, Peta J. White, Stephen Muecke Sep 2022

Regeneration Time: Ancient Wisdom For Planetary Wellbeing, Anne Poelina, Sandra Wooltorton, Mindy Blaise, Catrina Luz Aniere, Pierre Horwitz, Peta J. White, Stephen Muecke

Research outputs 2022 to 2026

In these regenerative times prompted by the Anthropocene, Aboriginal voices are situated to draw on ancient wisdom for local learning and to share information across the globe as ecological imperative for planetary wellbeing. In this paper, postqualitative research foregrounds the sentient nature of life as ancestral power and brings the vitality of co-becoming as our places into active engagement. It enables coloniality to surface and reveals how it sits in our places and lives, in plain sight but unnoticed because of its so-called common sense. Postqualitative research relates with ancient knowledges in foregrounding Country's animacy and presence, revealing the essence …


When And Why Consumers Choose Supersized Food?, Asim Qazi, Veronique Cova, Shahid Hussain, Ubedullah Khoso Sep 2022

When And Why Consumers Choose Supersized Food?, Asim Qazi, Veronique Cova, Shahid Hussain, Ubedullah Khoso

Research outputs 2022 to 2026

Purpose:

This study aims to achieve three objectives: to explore the perception of consumers about supersized foods (in both pre- and post-consumption scenarios), to identify why consumers prefer supersized options over other available options and to determine the types of situations that push consumers to make such decisions.

Design/methodology/approach:

This qualitative study uses the triangulation of projective methods, coupled with semi-structured interviews with 120 participants. The data was collected from major cities of Pakistan, using a convenient sample of 25 semi-structured interviews, 35 narratives and 60 sentence completions and constructions analyzed by performing thematic analysis.

Findings:

The findings indicate that …


Human Leucocyte Antigen Genotype Association With The Development Of Immune-Related Adverse Events In Patients With Non-Small Cell Lung Cancer Treated With Single Agent Immunotherapy, Afaf Abed, Ngie Law, Leslie Calapre, Johnny Lo, Vikas Bhat, Samantha Bowyer, Michael Millward, Elin S. Gray Sep 2022

Human Leucocyte Antigen Genotype Association With The Development Of Immune-Related Adverse Events In Patients With Non-Small Cell Lung Cancer Treated With Single Agent Immunotherapy, Afaf Abed, Ngie Law, Leslie Calapre, Johnny Lo, Vikas Bhat, Samantha Bowyer, Michael Millward, Elin S. Gray

Research outputs 2022 to 2026

Introduction: Biomarkers that predict the risk of immune-mediated adverse events (irAEs) among patients with non-small cell lung cancer (NSCLC) may reduce morbidity and mortality associated with these treatments. Methods: We carried out high resolution human leucocyte antigen (HLA)-I typing on 179 patients with NSCLC treated with anti-program death (PD)-1/program death ligand (PDL)-1. Toxicity data were collected and graded as per common terminology criteria for adverse event (CTCAE) v5.0. We used 14.8-week for landmark analysis to address lead-time bias to investigate the correlation between HLA-I/II zygosity, supertypes and alleles with irAE. Furthermore, we assessed the association for irAE with clinical benefit …


The Equity Theory: A Quantitative Perspective Using Data Envelopment Analysis, Parto Ahmadpour-Samani, Hosein Arman, Amirali Foukerdi, Abdollah Hadi-Vencheh, Reza Kiani Mavi Sep 2022

The Equity Theory: A Quantitative Perspective Using Data Envelopment Analysis, Parto Ahmadpour-Samani, Hosein Arman, Amirali Foukerdi, Abdollah Hadi-Vencheh, Reza Kiani Mavi

Research outputs 2022 to 2026

Equity theory (ET) is an organizational theory investigating how fairly people feel they have been treated. The literature on ET does not address two essential questions: what is the magnitude of the equity that one may perceive compared to other members in an organization?, and how much should be the resources (outcomes) of an underpaid member reduced (increased) to feel equal? The group members may respond to these questions emotionally, and their answers could be biased based on their personalities. This paper proposes a novel method using data envelopment analysis (DEA) to quantify the ET and answer these questions more …


Whole-Genome Sequencing Links Clostridium (Clostridioides) Difficile In A Single Hospital To Diverse Environmental Sources In The Community, Su-Chen Lim, Deirdre Collins, Korakrit Imwattana, Daniel R. Knight, Sicilia Perumalsamy, Natasza M.R. Hain-Saunders, Papanin Putsathit, David Speers, Thomas Riley Sep 2022

Whole-Genome Sequencing Links Clostridium (Clostridioides) Difficile In A Single Hospital To Diverse Environmental Sources In The Community, Su-Chen Lim, Deirdre Collins, Korakrit Imwattana, Daniel R. Knight, Sicilia Perumalsamy, Natasza M.R. Hain-Saunders, Papanin Putsathit, David Speers, Thomas Riley

Research outputs 2022 to 2026

To investigate if Clostridium (Clostridioides) difficile infection (CDI), traditionally thought of as hospital-acquired, can be genomically linked to hospital or community environmental sources, and to define possible importation routes from the community to the hospital.

In 2019, C. difficile was isolated from 89/300 (29.7%) floor and 96/300 (32.0%) shoe sole samples at a tertiary hospital in Western Australia. Non-toxigenic C. difficile ribotype (RT) 010 predominated among floor (96.6%) and shoe sole (73.2%) isolates, while toxigenic RT 014/020 was most prevalent among contemporaneous clinical cases (33.0%) at the hospital. Whole-genome sequencing and high-resolution core genome single nucleotide polymorphism (cgSNP) …


Abdominal Aortic Calcification On Lateral Spine Images Captured During Bone Density Testing And Late-Life Dementia Risk In Older Women: A Prospective Cohort Study, Tenielle Porter, Marc Sim, Richard L. Prince, John T. Schousboe, Catherine Bondonno, Wai H. Lim, Kun Zhu, Douglas P. Kiel, Jonathan M. Hodgson, Simon M. Laws, Joshua R. Lewis Sep 2022

Abdominal Aortic Calcification On Lateral Spine Images Captured During Bone Density Testing And Late-Life Dementia Risk In Older Women: A Prospective Cohort Study, Tenielle Porter, Marc Sim, Richard L. Prince, John T. Schousboe, Catherine Bondonno, Wai H. Lim, Kun Zhu, Douglas P. Kiel, Jonathan M. Hodgson, Simon M. Laws, Joshua R. Lewis

Research outputs 2022 to 2026

Background: Dementia after the age of 80 years (late-life) is increasingly common due to vascular and non-vascular risk factors. Identifying individuals at higher risk of late-life dementia remains a global priority. Methods: In prospective study of 958 ambulant community-dwelling older women ( ≥ 70 years), lateral spine images (LSI) captured in 1998 (baseline) from a bone density machine were used to assess abdominal aortic calcification (AAC). AAC was classified into established categories (low, moderate and extensive). Cardiovascular risk factors and apolipoprotein E (APOE) genotyping were evaluated. Incident 14.5-year late-life dementia was identified from linked hospital and mortality records. Findings: At …


Esculin Hydrolysis Negative And Tcda-Only Producing Strains Of Clostridium (Clostridioides) Difficile From The Environment In Western Australia, Nirajmohan Shivaperumal, Daniel R. Knight, Korakrit Imwattana, Grace O. Androga, Barbara J. Chang, Thomas V. Riley Sep 2022

Esculin Hydrolysis Negative And Tcda-Only Producing Strains Of Clostridium (Clostridioides) Difficile From The Environment In Western Australia, Nirajmohan Shivaperumal, Daniel R. Knight, Korakrit Imwattana, Grace O. Androga, Barbara J. Chang, Thomas V. Riley

Research outputs 2022 to 2026

Background and Aims: Clostridium (Clostridiodes) difficile clade 3 ribotype (RT) 023 strains that fail to produce black colonies on bioMérieux ChromID agar have been reported, as well as variant strains of C. difficile that produce only toxin A. We have recently isolated strains of C. difficile from the environment in Western Australia (WA) with similar characteristics. The objective of this study was to characterize these strains. It was hypothesized that a putative β-glucosidase gene was lacking in these strains of C. difficile, including RT 023, leading to white colonies. Methods and Results: A total of 17 environmental isolates of C. …


Proteome Phenotypes Discriminate The Growing Location And Malting Traits In Field-Grown Barley, Mahya Bahmani, Angéla Juhász, James Broadbent, Utpal Bose, Mitchell G. Nye-Wood, Ian B. Edwards, Michelle L. Colgrave Aug 2022

Proteome Phenotypes Discriminate The Growing Location And Malting Traits In Field-Grown Barley, Mahya Bahmani, Angéla Juhász, James Broadbent, Utpal Bose, Mitchell G. Nye-Wood, Ian B. Edwards, Michelle L. Colgrave

Research outputs 2022 to 2026

Barley is one of the key cereal grains for malting and brewing industries. However, climate variability and unprecedented weather events can impact barley yield and end-product quality. The genetic background and environmental conditions are key factors in defining the barley proteome content and malting characteristics. Here, we measure the barley proteome and malting characteristics of three barley lines grown in Western Australia, differing in genetic background and growing location, by applying liquid chromatography-mass spectrometry (LC-MS). Using data-dependent acquisition LC-MS, 1571 proteins were detected with high confidence. Quantitative data acquired using sequential window acquisition of all theoretical (SWATH) MS on barley …


Pre-Service Teachers’ Perceptions Of Problem-Based Learning For Developing Their Mathematics Teaching Pedagogy, David A. Martin, Romina Jamieson-Proctor Aug 2022

Pre-Service Teachers’ Perceptions Of Problem-Based Learning For Developing Their Mathematics Teaching Pedagogy, David A. Martin, Romina Jamieson-Proctor

Research outputs 2022 to 2026

The study reported in this paper was part of a larger study that explored pre-service teachers’ perceptions of the effectiveness of a problem-based learning (PBL) teaching approach for developing their mathematics pedagogical content knowledge (PCK) and their ability to enact their PCK in a tertiary mathematics education subject. This paper reports the qualitative semi-structured interviews used to capture the student voice with respect to the impact of the PBL approach used on the development of their mathematics PCK in comparison to their previous experiences with teacher-directed instruction. Overall, responses from the interviews revealed the pre-service teachers considered the PBL method …


‘That Teacher Really Likes Me’ - Student-Teacher Interactions That Initiate Teacher Expectation Effects By Developing Caring Relationships, Olivia Johnston, Helen Wildy, Jennifer Shand Aug 2022

‘That Teacher Really Likes Me’ - Student-Teacher Interactions That Initiate Teacher Expectation Effects By Developing Caring Relationships, Olivia Johnston, Helen Wildy, Jennifer Shand

Research outputs 2022 to 2026

Teacher expectations are associated with student academic achievement, but no research has generated new theory that explains how teacher expectation effects occur from students' perspectives. A substantive theory explaining the process through which students reconcile with their teachers' expectations is presented in this paper, emphasising the role of caring student-teacher relationships in teacher expectation effects on academic achievement. The theory was constructed with 25 grade 10 participants across three Western Australian secondary schools, with data including 100 interviews and 175 classroom observations. The analysis and synthesis of the data confirmed that the students acted in ways that they reflected improved …


Should Acupuncture-Related Therapies Be Considered In Prediabetes Control? Results From A Systematic Review And Meta-Analysis Of Randomized Controlled Trials, Min Zhang, Carol Chunfeng Wang, Johnny Lo Aug 2022

Should Acupuncture-Related Therapies Be Considered In Prediabetes Control? Results From A Systematic Review And Meta-Analysis Of Randomized Controlled Trials, Min Zhang, Carol Chunfeng Wang, Johnny Lo

Research outputs 2022 to 2026

To assess the effects and safety of acupuncture-related therapy (AT) interventions on glycemic control for prediabetes, we systematically searched 14 databases and 5 clinical registry platforms from inception to December 2020. Randomized controlled trials involving AT interventions for managing prediabetes were included (PROSPERO registration no. CRD42020209809). Of the 855 identified trials, 34 articles were included for qualitative synthesis, 31 of which were included in the final meta-analysis. Compared with usual care, sham intervention, or conventional medicine, AT treatments yielded greater reductions in the primary outcomes, including fasting plasma glucose (FPG) (standard mean difference [SMD] = -0.83; 95% confidence interval [CI], …


“Viewed With Suspicion, Considered Idle And Mocked-Working Caregiving Fathers And Fatherhood Forfeits”, Jasmine Kelland, Duncan Lewis, Virginia Fisher Aug 2022

“Viewed With Suspicion, Considered Idle And Mocked-Working Caregiving Fathers And Fatherhood Forfeits”, Jasmine Kelland, Duncan Lewis, Virginia Fisher

Research outputs 2022 to 2026

Existing academic literature consistently points to a changing role for modern fathers in which they take an egalitarian role in the caregiving responsibilities for their children. Despite this, fathers are observed to continue to dominate the realms of full-time working, aligning to more traditional breadwinning mentalities than such trends might suggest, raising questions around inequality. Fathers at work have previously been found to encounter challenges within the workplace when they alter, or consider altering their work patterns due to caregiving responsibilities. Employing a sample of working parents and managers, this paper explores how caregiving fathers are perceived within organizations and …


Effect Of Alloying Elements On The Compressive Mechanical Properties Of Biomedical Titanium Alloys: A Systematic Review, Syed Faraz Jawed, Chirag Dhirajlal Rabadia, Muhammad Ahmed Khan, Saad Jawaid Khan Aug 2022

Effect Of Alloying Elements On The Compressive Mechanical Properties Of Biomedical Titanium Alloys: A Systematic Review, Syed Faraz Jawed, Chirag Dhirajlal Rabadia, Muhammad Ahmed Khan, Saad Jawaid Khan

Research outputs 2022 to 2026

Due to problems such as the stress-shielding effect, strength-ductility trade-off dilemma, and use of rare-earth, expensive elements with high melting points in Ti alloys, the need for the design of new Ti alloys for biomedical applications has emerged. This article reports the effect of various alloying elements on the compressive mechanical performance of Ti alloys for biomedical applications for the first time as a systematic review following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines on this subject. The search strategy in this systematic review used Scopus, Web of Science, and PubMed databases and searched the articles …


Effects Of Various Solvents On Adsorption Of Organics For Porous And Nonporous Quartz Co2 Brine Systems: Implications For Co2 Geo-Storage, Muhammad Ali, Nurudeen Yekeen, Mujahid Ali, Mirhasan Hosseini, Nilanjan Pal, Alireza Keshavarz, Stefan Iglauer, Hussein Hoteit Aug 2022

Effects Of Various Solvents On Adsorption Of Organics For Porous And Nonporous Quartz Co2 Brine Systems: Implications For Co2 Geo-Storage, Muhammad Ali, Nurudeen Yekeen, Mujahid Ali, Mirhasan Hosseini, Nilanjan Pal, Alireza Keshavarz, Stefan Iglauer, Hussein Hoteit

Research outputs 2022 to 2026

The underground geo-storage of carbon dioxide (CO2) is an essential component of the carbon capture and sequestration value chain. The success of CO2 containment depends on the wetting state of the rock, which controls the mechanism of fluid flow and distribution. The presence of organic acids in the storage formation introduces a considerable effect on the wettability of the rock / CO2 / brine system under various temperature and pressure conditions. Despite the previous studies on this topic, the impact of the substrate pores, the rock surface roughness, and the solvents used to prepare the organic …


Increased Extent Of Waterfowl Grazing Lengthens The Recovery Time Of A Colonizing Seagrass (Halophila Ovalis) With Implications For Seagrass Resilience, Caitlyn M. O’Dea, Paul S. Lavery, Chanelle L. Webster, Kathryn M. Mcmahon Aug 2022

Increased Extent Of Waterfowl Grazing Lengthens The Recovery Time Of A Colonizing Seagrass (Halophila Ovalis) With Implications For Seagrass Resilience, Caitlyn M. O’Dea, Paul S. Lavery, Chanelle L. Webster, Kathryn M. Mcmahon

Research outputs 2022 to 2026

Herbivore distributions and abundance are shifting because of climate change, leading to intensified grazing pressure on foundation species such as seagrasses. This, combined with rapidly increasing magnitudes of change in estuarine ecosystems, may affect seagrass resilience. While the overall resilience of seagrasses is generally well-studied, the timeframes of recovery has received comparatively little attention, particularly in temperate estuaries. We investigated how the recovery time (RT) of seagrass is affected by simulated grazing in a southwestern Australian estuary. Whilst excluding swans, we simulated different grazing intensities (25, 50, 75, and 100 % removal from 1 m2 plots) at four locations in …


Feddp: A Privacy-Protecting Theft Detection Scheme In Smart Grids Using Federated Learning, Muhammad Mansoor Ashraf, Muhammad Waqas, Ghulam Abbas, Thar Baker, Ziaul Haq Abbas, Hisham Alasmary Aug 2022

Feddp: A Privacy-Protecting Theft Detection Scheme In Smart Grids Using Federated Learning, Muhammad Mansoor Ashraf, Muhammad Waqas, Ghulam Abbas, Thar Baker, Ziaul Haq Abbas, Hisham Alasmary

Research outputs 2022 to 2026

In smart grids (SGs), the systematic utilization of consumer energy data while maintaining its privacy is of paramount importance. This research addresses this problem by energy theft detection while preserving the privacy of client data. In particular, this research identifies centralized models as more accurate in predicting energy theft in SGs but with no or significantly less data protection. Current research proposes a novel federated learning (FL) framework, namely FedDP, to tackle this issue. The proposed framework enables various clients to benefit from on-device prediction with very little communication overhead and to learn from the experience of other clients with …


Decentralized Disturbance Observer-Based Sliding Mode Load Frequency Control In Multiarea Interconnected Power Systems, Farhad Farivar, Octavian Bass, Daryoush Habibi Aug 2022

Decentralized Disturbance Observer-Based Sliding Mode Load Frequency Control In Multiarea Interconnected Power Systems, Farhad Farivar, Octavian Bass, Daryoush Habibi

Research outputs 2022 to 2026

The load frequency control (LFC) problem in interconnected multiarea power systems is facing more challenges due to increasing uncertainties caused by the penetration of intermittent renewable energy resources, random changes in load patterns, uncertainties in system parameters and unmodeled system dynamics, leading to a compromised reliability of power systems and increasing the risk of power outages. In responding to this problem, this paper proposes a decentralized disturbance observer-based sliding mode LFC scheme for multiarea interlinked power systems with external disturbances. First, a reduced power system order is constructed by lumping disturbances from tie-line power deviations, load variations and the output …


Challenges Experienced By Newly Qualified Nurse-Midwives Transitioning To Practice In Selected Midwifery Settings In Northern Malawi, Mathews Brave Mtegha, Elizabeth Chodzaza, Ellen Chirwa, Fatch Welcome Kalembo, Maggie Zgambo Aug 2022

Challenges Experienced By Newly Qualified Nurse-Midwives Transitioning To Practice In Selected Midwifery Settings In Northern Malawi, Mathews Brave Mtegha, Elizabeth Chodzaza, Ellen Chirwa, Fatch Welcome Kalembo, Maggie Zgambo

Research outputs 2022 to 2026

Background: Literature shows that newly qualified nurse-midwives face challenges integrating into the workforce during their transition period from education to practice. However, little is known about the needs and challenges of Malawian nurse-midwives during their transition from education to practice. The aim of the study was to explore the transition experiences of newly qualified nurse-midwives working in selected midwifery units in Northern Malawi. Methodology: A qualitative descriptive approach was used. Data were collected through in-depth interviews using semi-structured interview guides from a purposive sample of 19 participants (13 newly qualified nurse-midwives and 6 key informants). The researchers developed two interview …


Metabolomics Reveals Mouse Plasma Metabolite Responses To Acute Exercise And Effects Of Disrupting Ampk-Glycogen Interactions, Mehdi R. Belhaj, Nathan G. Lawler, John A. Hawley, David I. Broadhurst, Nolan J. Hoffman, Stacey N. Reinke Aug 2022

Metabolomics Reveals Mouse Plasma Metabolite Responses To Acute Exercise And Effects Of Disrupting Ampk-Glycogen Interactions, Mehdi R. Belhaj, Nathan G. Lawler, John A. Hawley, David I. Broadhurst, Nolan J. Hoffman, Stacey N. Reinke

Research outputs 2022 to 2026

Introduction: The AMP-activated protein kinase (AMPK) is a master regulator of energy homeostasis that becomes activated by exercise and binds glycogen, an important energy store required to meet exercise-induced energy demands. Disruption of AMPK-glycogen interactions in mice reduces exercise capacity and impairs whole-body metabolism. However, the mechanisms underlying these phenotypic effects at rest and following exercise are unknown. Furthermore, the plasma metabolite responses to an acute exercise challenge in mice remain largely uncharacterized. Methods : Plasma samples were collected from wild type (WT) and AMPK double knock-in (DKI) mice with disrupted AMPK-glycogen binding at rest and following 30-min submaximal treadmill …


Metabolomics In Pulmonary Medicine: Extracting The Most From Your Data, Stacey N. Reinke, Romanas Chaleckis, Craig E. Wheelock Aug 2022

Metabolomics In Pulmonary Medicine: Extracting The Most From Your Data, Stacey N. Reinke, Romanas Chaleckis, Craig E. Wheelock

Research outputs 2022 to 2026

The metabolome enables unprecedented insight into biochemistry, providing an integrated signature of the genome, transcriptome, proteome and exposome. Measurement requires rigorous protocols combined with specialised data analysis to achieve its promise.


Thermo-Responsive Hydrophilic Support For Polyamide Thin-Film Composite Membranes With Competitive Nanofiltration Performance, Haniyeh Najafvand Drikvand, Mitra Golgoli, Masoumeh Zargar, Mathias Ulbricht, Siamak Nejati, Yaghoub Mansourpanah Aug 2022

Thermo-Responsive Hydrophilic Support For Polyamide Thin-Film Composite Membranes With Competitive Nanofiltration Performance, Haniyeh Najafvand Drikvand, Mitra Golgoli, Masoumeh Zargar, Mathias Ulbricht, Siamak Nejati, Yaghoub Mansourpanah

Research outputs 2022 to 2026

Poly(N-isopropylacrylamide) (PNIPAAm) was introduced into a polyethylene terephthalate (PET) nonwoven fabric to develop novel support for polyamide (PA) thin-film composite (TFC) membranes without using a microporous support layer. First, temperature-responsive PNIPAAm hydrogel was prepared by reactive pore-filling to adjust the pore size of non-woven fabric, creating hydrophilic support. The developed PET-based support was then used to fabricate PA TFC membranes via interfacial polymerization. SEM–EDX and AFM results confirmed the successful fabrication of hydrogel-integrated non-woven fabric and PA TFC membranes. The newly developed PA TFC membrane demonstrated an average water permeability of 1 L/m2 h bar, and an NaCl rejection of …


Machining Of Carbon Steel Under Aqueous Environment: Investigations Into Some Performance Measures, Mushtaq Ali, Tahir Abdul Hussain Ratlamwala, Ghulam Hussain, Tauheed Shehbaz, Riaz Muhammad, Muhammad Aamir, Khaled Giasin, Danil Yurievich Pimenov Aug 2022

Machining Of Carbon Steel Under Aqueous Environment: Investigations Into Some Performance Measures, Mushtaq Ali, Tahir Abdul Hussain Ratlamwala, Ghulam Hussain, Tauheed Shehbaz, Riaz Muhammad, Muhammad Aamir, Khaled Giasin, Danil Yurievich Pimenov

Research outputs 2022 to 2026

In this study, a new machining approach (aqueous machining) is applied for mill machining and its performance is compared with traditional wet machining. AISI 1020 steel is employed as the test material and Taguchi statistical methodology is implemented to analyze and compare the performance of the two machining approaches. The cutting speed, feed rate, and depth of cut were the machining parameters used for both types of machining, while the selected response variables were surface roughness and hardness. Temperature variations were also recorded in aqueous machining. Compared with wet machining, aqueous machining resulted in lower surface roughness (up to 13 …


Visually Identified Tau 18f-Mk6240 Pet Patterns In Symptomatic Alzheimer's Disease, Natasha Krishnadas, Kun Huang, Stephanie A. Schultz, Vincent Doré, Pierrick Bourgeat, Anita M. Y. Goh, Fiona Lamb, Svetlana Bozinovski, Samantha C. Burnham, Joanne S. Robertson, Simon M. Laws, Paul Maruff, Colin L. Masters, Victor L. Villemagne, Christopher C. Rowe Aug 2022

Visually Identified Tau 18f-Mk6240 Pet Patterns In Symptomatic Alzheimer's Disease, Natasha Krishnadas, Kun Huang, Stephanie A. Schultz, Vincent Doré, Pierrick Bourgeat, Anita M. Y. Goh, Fiona Lamb, Svetlana Bozinovski, Samantha C. Burnham, Joanne S. Robertson, Simon M. Laws, Paul Maruff, Colin L. Masters, Victor L. Villemagne, Christopher C. Rowe

Research outputs 2022 to 2026

Background: In Alzheimer's disease, heterogeneity has been observed in the postmortem distribution of tau neurofibrillary tangles. Visualizing the topography of tau in vivo may facilitate clinical trials and clinical practice. Objective: This study aimed to investigate whether tau distribution patterns that are limited to mesial temporal lobe (MTL)/limbic regions, and those that spare MTL regions, can be visually identified using 18F-MK6240, and whether these patterns are associated with different demographic and cognitive profiles. Methods : Tau 18F-MK6240 PET images of 151 amyloid-β positive participants with mild cognitive impairment (MCI) and dementia were visually rated as: tau negative, limbic predominant (LP), …


Association Of Abdominal Aortic Calcification With Peripheral Quantitative Computed Tomography Bone Measures In Older Women: The Perth Longitudinal Study Of Ageing Women, Jack Dalla Via, Marc Sim, John T. Schousboe, Douglas P. Kiel, Kun Zhu, Jonathan M. Hodgson, Abadi K. Gebre, Robin M. Daly, Richard L. Prince, Joshua R. Lewis Aug 2022

Association Of Abdominal Aortic Calcification With Peripheral Quantitative Computed Tomography Bone Measures In Older Women: The Perth Longitudinal Study Of Ageing Women, Jack Dalla Via, Marc Sim, John T. Schousboe, Douglas P. Kiel, Kun Zhu, Jonathan M. Hodgson, Abadi K. Gebre, Robin M. Daly, Richard L. Prince, Joshua R. Lewis

Research outputs 2022 to 2026

We have previously shown that abdominal aortic calcification (AAC), a marker of advanced atherosclerotic disease, is weakly associated with reduced hip areal bone mineral density (aBMD). To better understand the vascular–bone health relationship, we explored this association with other key determinants of whole-bone strength and fracture risk at peripheral skeletal sites. This study examined associations of AAC with peripheral quantitative computed tomography (pQCT)-assessed total, cortical and trabecular volumetric BMD (vBMD), bone structure and strength of the radius and tibia among 648 community-dwelling older women (mean ± SD age 79.7 ± 2.5 years). We assessed associations between cross-sectional (2003) and longitudinal …


Comparing Biomechanical Time Series Data Across Countermovement Shrug Loads, David Meechan, Stuart A. Mcerlain-Naylor, John J. Mcmahon, Timothy J. Suchomel, Paul Comfort Aug 2022

Comparing Biomechanical Time Series Data Across Countermovement Shrug Loads, David Meechan, Stuart A. Mcerlain-Naylor, John J. Mcmahon, Timothy J. Suchomel, Paul Comfort

Research outputs 2022 to 2026

The effect of load on time-series data has yet to be investigated during weightlifting derivatives. This study compared the effect of load on the force–time and velocity–time curves during the countermovement shrug (CMS). Twenty-nine males performed the CMS at relative loads of 40 %, 60 %, 80 %, 100 %, 120 %, and 140 % one repetition maximum (1RM) power clean (PC). A force plate measured the vertical ground reaction force (VGRF), which was used to calculate the barbell-lifter system velocity. Time-series data were normalized to 100 % of the movement duration and assessed via statistical parametric mapping (SPM). SPM …


3d Fracture Propagation Simulation And Pressure Decline Analysis Research For I-Shaped Fracture Of Coalbed, Chengwang Wang, Zixi Guo, Lifeng Zhang, Yunwei Kang, Zhenjiang You, Shuguang Li, Yubin Wang, Huaibin Zhen Aug 2022

3d Fracture Propagation Simulation And Pressure Decline Analysis Research For I-Shaped Fracture Of Coalbed, Chengwang Wang, Zixi Guo, Lifeng Zhang, Yunwei Kang, Zhenjiang You, Shuguang Li, Yubin Wang, Huaibin Zhen

Research outputs 2022 to 2026

After hydraulic fracturing, some treatments intended for production enhancement fail to yield predetermined effects. The main reason is the insufficient research about the fracture propagation mechanism. There is compelling evidence that I-shaped fracture, two horizontal fractures at the junction of coalbed and cover/bottom layer, and one vertical fracture in the coalbed have formed in part of the coalbed after hydraulic fracturing. Therefore, this paper aims at I-shaped fracture propagation simulation. A novel propagation model is derived on the basis of a three-dimensional (3D) model, and the coupling conditions of vertical fracture and horizontal fractures are established based on the flow …