Digital Commons Network^™

From Hermeneutic Theory To Pedagogical Practice: Dialogue, Fusion Of Horizons, And Tradition In The Philosophy For Children Classroom, Leon Benade

Research outputs 2022 to 2026

This article brings Hans-Georg Gadamer’s philosophical hermeneutics into critical conversation with the pedagogical practice of philosophy in schools, focusing particularly on Philosophy for Children (P4C). While P4C offers a rich pedagogical model for developing reasonableness through the Community of Inquiry (CoI), its account of the conditions under which understanding occurs remains somewhat underdeveloped. Although some scholars have situated P4C in relation to hermeneutics, this engagement is limited. Addressing this gap, the key Gadamerian ideas of tradition, prejudice, and the fusion of horizons and dialogue are explored here to deepen and extend the theoretical considerations of inquiry in P4C. The discussion …

Inpatient Versus Outpatient Management Of Bilateral Optic Nerve Head Elevation Presentation To A Tertiary Emergency Department, Mengchen Suo, Johnny Lo, Fred K. Chen

Research outputs 2022 to 2026

Introduction: Increased accessibility to fundus cameras has changed the referral pattern for patients with suspected bilateral optic nerve head elevation (BONHE) presenting to emergency departments (EDs). We aim to review the management of these patients to streamline the process. Methods: A retrospective review of patients with suspected BONHE referred to a tertiary centre ED between 2017 and 2022. We collected demographics, referral source, clinical assessment, neuroimaging and retinal imaging results. Final diagnosis and treatment outcomes were compared between those managed as inpatients and those managed as outpatients. Results: 100 patients were referred to the ED with a suspected BONHE. Most …

Integrative Oncology For Prostate Cancer: A Narrative Review, Kevin T. Liou, Nicole A. Metri, Robert U. Newton, Divya Ajay, Eleanor M. Walker, Channing J. Paller

Research outputs 2022 to 2026

Prostate cancer is most common malignancy among men in the United States. As men are now living longer with prostate cancer due to advances in treatment, there exists a growing need to manage the long-term physical and psychological sequelae of this disease, which range from genitourinary dysfunction to cardiometabolic and psychosocial consequences. Over half of men with prostate cancer report unmet needs in symptom management. Integrative oncology, a patient-centered, evidence-informed field combining lifestyle, natural product, and mind–body interventions with conventional treatments, offers a promising approach to prostate cancer symptom management. This review summarizes the current landscape of integrative oncology research …

Optimal Co2 Storage Interval In Heterogeneous Tight Formation: Implications For Long-Term Carbon Sequestration, Yujie Yuan, Yuxin Cao, Emad A. Al-Khdheeawi, Maxim Lebedev, Zhenjiang You, Reza Rezaee, Stefan Iglauer, Lai Chang Zhang, Zhuo Feng

Research outputs 2022 to 2026

The efficiency of CO2 geo-sequestration relies heavily on the storage capacity and sealing integrity of the heterogeneous strata. Tight formations offer substantial advantages for long-term CO2 geological storage, however, the stratigraphic variability and lithological heterogeneity introduce substantial uncertainty in real-world engineering applications. Particularly, for tight formations with pronounced heterogeneous lithologies, traditional methods oversimplify their impact on CO2 geo-sequestration. To address this challenge and identify the most effective intervals for CO2 geo-sequestration, we investigated the middle Permian Lucaogou Formation (P2l) in the Jimusar Sag, Junggar Basin, Northwest China, a region known for its strong lithological heterogeneity. By integrating multi-scale analytical techniques, …

Predicting Accumulation And Age At Onset Of Amyloid-Β From Genetic Risk And Resilience For Alzheimer's Disease, Eleanor K. O'Brien, Timothy Cox, Shane Fernandez, Pierrick Bourgeat, Tenielle Porter, Ben Goudey, James D. Doecke, Colin L. Masters, Jurgen Fripp, Kwangsik Nho, Victor L. Villemagne, Carlos Cruchaga, Christopher C. Rowe, Andrew J. Saykin, Vincent Doré, Simon M. Laws

Research outputs 2022 to 2026

Background: Accumulation of brain amyloid beta (Aβ), a key pathological hallmark of Alzheimer's disease (AD), begins decades before cognitive symptoms. Being able to predict the risk of Aβ accumulation, or the age at which Aβ exceeds a critical threshold, may enable intervention to delay or prevent onset of AD. Methods: Using published genome-wide association studies (GWASs), we developed polygenic scores (PGS) for AD risk (PGSrisk) and resilience (PGSresilience), and tested whether these predicted (i) if an individual is an Aβ accumulator (‘Accumulator Status’), and (ii) in accumulators, the age at which brain Aβ exceeds a 20 centiloid (CL) threshold (‘Age …

Sliding Mode Control In Grid-Tied Inverters: Techniques, Applications, And Future Directions, Taimoor Muzaffar Gondal, Asma Aziz, Daryoush Habibi, Iftekhar Ahmad

Research outputs 2022 to 2026

Sliding mode control (SMC) has emerged as a robust and adaptive strategy for grid-tied inverters. It has unique attributes which make it an appropriate control choice under increasingly complex power systems. However, there are a limited number of review articles which comprehensively explore the true potential of SMC for grid-tied inverter applications. This systematic review has been structured to explore SMC techniques with respect to certain challenges, i.e., stability challenges, unbalanced conditions, low inertia scenarios, and harmonics distortion. The classification of various SMC techniques is presented with respect to their control law and sliding surfaces design. The comparative analysis indicates …

The Effect Of Cyp1a2 Gene Polymorphisms On Caffeine Pharmacokinetics And Exercise Performance In Male Recreational Athletes, Chloe Masters, Ajmol Ali, Claire Badenhorst, Martin Dickens, Kay Rutherfurd-Markwick

Research outputs 2022 to 2026

This study examined the effects of caffeine consumption on endurance exercise performance, and the influence of CYP1A2 gene polymorphisms in caffeine pharmacokinetics and exercise performance. The data sets of two randomised, double blind, placebo-controlled crossover study design experiments have been merged. Thirty-eight recreationally active male participants provided saliva samples for CYP1A2 genotyping (AA homozygotes n = 19; AC heterozygotes n = 19) and completed either a 10-km run or 40-km cycling time trial of 60-min following a single dose of 6 mg·kg⁻¹ caffeine (CAF) or placebo (maltodextrin; PLA) throughout which heart rate (HR) and time to completion (TTC) were …

Dasyurus Hallucatus Movement Response To Fire In A Complex, Resource Rich Tropical Savanna, Ian J. Radford, Annette Cook, Natasha Harrison, Ben Corey, Roberta Bencini, Harriet R. Mills

Research outputs 2022 to 2026

The northern quoll, Dasyurus hallucatus, is part of a suite of threatened native northern Australian mammals that have inappropriate fire regimes listed as a threatening process. However, fire responses reported for D. hallucatus are inconsistent among different studies. Based on the theory that the fire response of D. hallucatus will depend partially on habitat quality, we postulate that home range in high quality savannas of the north Kimberley will be small, post-breeding male mortality low and prey resources little affected by fire. Based on previous research we hypothesised that male D. hallucatus would respond to fire more than females. By …

Diversity And Inclusivity In Australian Dementia Prevention Research: A Mixed Methods Review, Olivia E. Giameos, Maddison L. Mellow, Diana Karamacoska, Aaron Davis, Paul A. Gardiner, Eddy Roccati, Kaarin J. Anstey, Nicolas Cherbuin, Jessica M. Adsett, Nikki Anne Wilson, Kylie Radford, Louise Lavrencic, Perminder S. Sachdev, Simone Reppermund, Suraj Samtani, Annabel P. Matison, Zara A. Page, Philip J. Batterham, Sophie C. Andrews, Alex Bahar-Fuchs, Michelle K. Lupton, Andrew Pipingas, Adrienne Withall, Belinda M. Brown, Helen Macpherson, Hannah A.D. Keage, Britt Burton, James C. Vickers, David W. Dunstan, Ashleigh E. Smith

Research outputs 2022 to 2026

Minoritized communities are disproportionately impacted by modifiable dementia risk factors but are underrepresented in dementia research globally. In Australia, the number of dementia prevention cohort and intervention studies has rapidly increased in the past two decades, yet the representation of minoritized groups has not been synthesized. The aims of this mixed-methods review were to summarize the demographic characteristics of participants involved in Australian dementia prevention-focused cohort and intervention studies. A systematic search of published literature, funded grant outcomes, and clinical trial registrations was conducted in October 2023 and updated in February 2025 to identify any Australia-based cohort or intervention studies …

Forecast: An Exhibition Inviting Slow Feeling Through Participation In Unstable Weather States, Jo Pollitt, Helena Grehan, Lilly Blue, Peggy Attkinson, Justine Dandy, Naomi Joy Godden, Leanda Mason, Renee Esther Newman, Alexa Taylor, Danielle Gilson

Research outputs 2022 to 2026

This paper presents a series of responses from Western Australian based artists and scholars from a range of disciplines including: meteorology, science, education, social work, psychology, art and performance studies, to a year-long exhibition titled Forecast in Gallery 09 at The Art Gallery of Western Australia (AGWA). Forecast is a collaboration between AGWA's Head of Learning and Creativity Research, Lilly Blue, Edith Cowan University's Centre for People, Place and Planet artist-scholar, Jo Pollitt, together with artists Dianne Jones and Eva Fernández. The exhibition invites audiences to contribute to two participatory works: Weather Patterns, a daily changing installation that makes room …

Muscle–Tumor Crosstalk In Exercise Oncology: Exercise-Induced Myokines And Cancer Cachexia, Amirhossein Ahmadi Hekmatikar, Francesco Bettariga, Álvaro López Llorente, Diego Fernández-Lázaro, Katsuhiko Suzuki, D. Maryama Awang Daud

Research outputs 2022 to 2026

Exercise-induced myokines, such as IL-6, irisin, and myostatin, play crucial roles in mediating systemic adaptations and modulating tumor progression. This narrative review synthesizes evidence on how regular moderate-intensity exercise affects the myokine network within the tumor microenvironment (TME) of solid tumors. Results from the 86 included studies indicate that structured training (aerobic: 45–65% VO2 max; resistance: 45–70% 1RM) enhances the expression of beneficial myokines that support immune surveillance, reduce inflammation, and improve muscle–tumor cross-talk. IL-6 demonstrates a dual modulatory effect on inflammation and immunity; irisin contributes to tumor apoptosis, while myostatin downregulation supports muscle integrity and metabolic balance. Evidence suggests …

Analysis Of Normalization, Resampling, And Weighted Voting To Improve K-Nn Performance In Diabetes Disease Detection, Agustiyar, R. Rizal Isnanto, Budi Warsito, Adi Wibowo, Ferry Jie

Research outputs 2022 to 2026

Diabetes is a global health issue, and machine learning has become crucial for early detection. The k-Nearest Neighbors (k-NN) machine learning algorithm is widely used because it is simple and easy to implement; however, its performance is sensitive to feature scale differences, class imbalance, and the assumption of uniform decision-making, as commonly found in clinical datasets such as the Pima Indians Diabetes (PID) dataset. Many studies have been conducted to address these issues; however, very few have systematically evaluated the combined effects of preprocessing and distance-based decision-making methods on k-NN performance. This study evaluates the combined effects of preprocessing strategies …

Review And Development Of An Explicit Machine Learning Model For Pollutant Gas Solubility In Ionic Liquids As Green Solvents, Amir Dashti, Farid Amirkhani, Mojtaba Raji, John L. Zhou, Ali Altaee, Ali Braytee, Brett Turner, Hossein Ali Khonakdar, Amir Razmjou

Research outputs 2022 to 2026

The increasing release of greenhouse gases (GHGs) like CO₂, CH₄, N₂O, and industrial contaminants (indirect GHGs) such as SO₂ and H₂S has prompted significant global worries due to their role in climate change, air pollution, and harm to the environment. Ionic liquids (ILs) as green solvents have emerged as promising alternatives to traditional solvents because of their minimal volatility, high thermal stability, and adjustable physicochemical characteristics. Yet, limited gas solubility data in ILs is hindering their applications in carbon capture and air pollution control. Machine learning (ML) is a powerful tool for modeling and simulating the solubility of polluting gases …

Does Set Configuration Influence Long-Term Adaptations To Complex Training In National-Level Wrestlers? A Volumematched Randomized Trial, Yueqiang Ma, Pengpeng Gou, Yuxiong Huang, Jialiang Yu, Lijia Zhou, Kai Xu, Binbin Jia, Danyang Li

Research outputs 2022 to 2026

Objectives: Complex training is commonly used to enhance strength and explosive performance in athletes; however, the long-term influence of set configuration within complex training remains unclear in highly trained wrestlers. This randomized, volumematched trial investigated whether set configuration influences long-term adaptations to complex training (CT) in national-level male Chinese-style wrestlers. Specifically, the study compared the effects of cluster-set complex training (CS-CT) and traditional-set complex training (TS-CT) on maximal strength, lower-limb explosive performance, anaerobic power, and sport-specific performance.

Methods: Sixteen highly trained wrestlers (Tier 3; n=16) completed an 8-week lowerbody CT program performed twice weekly. Participants were randomly allocated to either …

Effectiveness Of Lay Workers Delivering Behavioural Activation For People With Depression: Systematic Review And Meta-Analysis, Shwikar Othman, Lauren Blekkenhorst, Asangaedem Akpan, Irene Ngune, Nilufeur Mckay, Alison Kennedy, Elizabeth Armstrong, Michael Hunter, Kevin Murray, Mathew Coleman, Richard Gray, Emma Jones, Christopher Lee, Martin Jones

Research outputs 2022 to 2026

Background Behavioural activation is effective for depression, but its effectiveness in treating adults with depression when delivered by lay workers remains unclear. Aims To examine the effectiveness of behavioural activation delivered by lay workers, compared with any control group, in reducing depressive symptoms in adults. Method This systematic review searched six databases from inception to January 2025, for randomised controlled trials (RCTs) comparing behavioural activation and any control conditions for individuals with depression when delivered by lay workers. Additional searches were conducted in the international trial registries and reference lists (PROSPERO registration CRD42024625620). Risk of bias was assessed using the …

Corporate Eldercare Responsibility: Forging A Strategic Approach To Sustaining Work–Care Balance, Kazunori Kobayashi, Gabriel Eweje, Mayowa Babalola, Tazeeb Rajwani

Research outputs 2022 to 2026

Purpose – Population ageing is intensifying pressures on employees with eldercare responsibilities, yet eldercare remains weakly addressed within corporate social responsibility (CSR) and business strategy research. This study aims to examine how firms strategically respond to these emerging pressures and develops the concept of corporate eldercare responsibility. Design/methodology/approach – The study draws on qualitative interviews with senior managers in large Japanese corporations. The analysis focuses on how firms interpret eldercare-related challenges and translate them into organisational responses within existing employment and CSR strategy frameworks. Findings – The findings identify two distinct CSR logics shaping organisational responses. Provision-focused practices extend supports …

An International Multidisciplinary Consensus Statement On Laparoscopic Liver Biopsy, Si Yi Lei, Yu Han, Don C. Rockey, Khalid Alswat, Vincent Wai Sun Wong, Nozim Jumaev, Carlos Jesus Toro-Huamanchumo, Safwan Taha, Mohamed El-Kassas, Jacob George, Mark Muthiah, Omar Ghanem, Masato Yoneda, Dao Viet Hang, Giada Sebastiani, George Papatheodoridis, Adam Abu-Abeid, Andrew G. Robertson, Sang Hyun Kim, Rudolf Weiner, Kamal Mahawar, Asim Shabbir, Mohammad Kermansaravi, Reynu Rajan, Yosuke Seki, Halit Eren Taskin, Scott Shikora, Edward Oliveros, Chetan Parmar, Qiuye Cheng, Omar Thaher, Elena Ruiz-Úcar, Rodolfo Oviedo, Rui Ribeiro, Mario Musella, Almino C. Ramos, Seung-Wan Ryu, Tamer Abdelbaki, Wei Jei Lee, Man Pan Chan, Jose Eduardo Garcia Flores, James Skinovsky, Ahmad Madkhali, Sylvia Weiner, Frank Tacke, Wah Yang, James Neuberger, Ming-Hua Zheng

Research outputs 2022 to 2026

Laparoscopic liver biopsy (LLB) provides a way to obtain liver tissue samples under direct visual inspection of the liver surface. It complements percutaneous liver biopsy (PLB) for complex or high-risk cases where PLB cannot be performed. Clinical practices for LLB vary across centers due to the lack of international standards. To improve the procedural quality and diagnostic efficiency of LLB, a multidisciplinary panel of 45 international experts from 6 continents, including hepatology, hepatobiliary surgery, gastrointestinal surgery, and metabolic and bariatric surgery, developed this consensus statement through three rounds of a modified Delphi process. This consensus covers clinical application scenarios, high-risk …

Bridging The Gender Gap In Ghanaian Local Governance: Key Enablers And Pathways, Martin Brantuo, Victor Fannam Nunfam, Joseph Akanganngang Asitik, Ebenezer Afrifa-Yamoah

Research outputs 2022 to 2026

This qualitative study examines factors facilitating women’s election to District Assemblies in Ghana through social capital and supply–demand theoretical frameworks. Through interviews with thirteen female Assembly members and four officials, the research identifies four critical enablers: financial resources, political affiliations, community relationships, and educational qualifications. Financial resources emerged as crucial for campaign management and voter mobilization, while political party support provided strategic advantages despite the nonpartisan nature of local elections. Strong interpersonal relationships within communities proved vital for building voter trust, and educational background enhanced candidates’ credibility. The findings inform recommendations for implementing gender quotas, establishing campaign funding mechanisms, voter …

Using Social Return On Investment To Evaluate Services That Support The Health Of People Experiencing Homelessness In Australia: A Scoping Review, Cate Mckenna, Christopher Rouen, Mary O'Loughlin

Research outputs 2022 to 2026

The increasing demand for homelessness services in Australia highlights the need for robust evaluation methodologies to assess their social impact. Traditional economic evaluation methods often struggle to capture the intangible social and health outcomes associated with homelessness. Social return on investment (SROI), an outcomes-based framework driven by stakeholders, offers a flexible and comprehensive approach to measuring social, economic and environmental impacts. This scoping review examines the application of SROI in evaluating services that support the health of people experiencing or at risk of homelessness in Australia. A total of 25 reports from grey literature (2010-2023) were reviewed. The findings reveal …

Where To Now With Privacy? A Systematic Literature Review With Human–Artificial Intelligence Synthesis (Slr-Hais), Moulik M. Zaveri, Ameet Pandit, Violetta Wilk, Steven D’Alessandro

Research outputs 2022 to 2026

Purpose – The development of digital technologies has led to changes in how consumers perceive privacy. This systematic literature review (SLR) aims to introduce human–artificial intelligence (AI) synthesis (HAIS) as a novel methodology for extending traditional SLRs. Design/methodology/approach – A comprehensive review of the privacy literature is conducted to demonstrate the efficacy of the SLR with HAIS (SLR-HAIS) approach, using 149 articles published by top marketing journals on consumer privacy. The PRISMA approach is adopted as the organizing framework. In addition, the TCCM framework is applied in conjunction with Leximancer-driven HAIS analysis, which utilizes natural language processing techinques for thematic …

Implementation Of Co-Designed Strategies Enhances Referral To Pulmonary Rehabilitation For People With Copd In Tertiary Care: An Interrupted Time Series Study, Sarah Hug, Vinicius Cavalheri, Daniel F. Gucciardi, Richard Norman, Christine Teague, Natasha Bear, Kylie Hill, Optimal Consortium

Research outputs 2022 to 2026

Background: Pulmonary rehabilitation programs (PRPs) are a core component of care for people with chronic obstructive pulmonary disease (COPD), yet referral is low. The aims of this study were to; (i) engage with people with COPD receiving care at a tertiary hospital and HCPs involved in the management of people with COPD, to co-design and implement strategies that sought to improve referrals to PRPs; (ii) evaluate the effect of implementing co-designed strategies on the rate of referral to PRPs across three tertiary hospitals; and (iii) understand the sustainability of co-designed strategies by estimating relative costs and number of potentially prevented …

Proteomic Evidence Indicates Ultrasound-Assisted Extraction Enhances Recovery Of Membrane-Associated Proteins In Hericium Erinaceus, Tanvir Ahmed, Angéla Juhász, Utpal Bose, Netsanet Shiferaw Terefe, Michelle L. Colgrave

Research outputs 2022 to 2026

Membrane-associated fungal proteins mediate essential functions and contain bioactive proteins with therapeutic potential but are underrepresented in aqueous extracts due to hydrophobicity and lipid associations. Ultrasound-assisted aqueous extraction was applied to Lion’s mane (Hericium erinaceus), and the proteins were fractionated by molecular weight (≥30 kDa, 10–30 kDa, 3–10 kDa). Proteomic profiling using data-dependent (DDA) and data-independent (DIA) mass spectrometry identified 1500 and 1702 proteins, respectively (1% global FDR). Ultrasonication induced surface irregularity and a less compact, heterogeneous microstructure. Topology predictions showed higher proportions of transmembrane and secretory proteins in ultrasonicated fractions. Extraction preserved protein integrity (82% molecular-weight retention, 97% tryptic …

Norm Dust Intake: Comparison Of Personal Air Sampling And Bioassays, Gregory S. Hewson, Martin I. Ralph, Marcus Cattani

Research outputs 2022 to 2026

Intake of naturally occurring radioactive materials (NORM), particularly the inhalation of thorium-bearing dust in mineral sand operations, has traditionally been assessed via personal air sampling (PAS). However, data from bioassay studies suggest that the actual intake determined via PAS may be underestimated. This review integrates thorium intake estimates derived from historical bioassay datasets, such as urine, faeces, lung counting, and thoron-in-breath tests, with historical PAS data. The findings indicated that bioassay-based predictions of intake were consistently greater, with mean bioassay-to-PAS intake ratios ranging from 2.6 to 4.2. The contributing factors to this discrepancy include biokinetic model uncertainties, potential dust sampler …

Patterns Of Language And Visuospatial Lateralisation In Three-Year-Old Children, Josephine E. Quin-Conroy, Donna M. Bayliss, Stephanie J. Bovell, Debra Eamer, Georgina H.M. Earl, Simon E. Fisher, Clyde Francks, Murray T. Maybery, Sarah Pillar, Desiree Silva, Andrew J.O. Whitehouse, Nicholas A. Badcock

Research outputs 2022 to 2026

Little is known about how or when language and visuospatial processing lateralise in the brain, and if individual differences in lateralisation are related to early language or visuospatial abilities. We explored if patterns of language and visuospatial lateralisation are related to cognitive skills in young children. A large sample of 3-year-olds (n = 136) attempted two functional transcranial Doppler ultrasound (fTCD) tasks to estimate language and visuospatial lateralisation. At the group level, language was lateralised to the left hemisphere, but visuospatial processing was weakly lateralised to the right hemisphere. The relationship between patterns of lateralisation and cognitive skills was investigated …

Approach–Avoidance Motivation And Goal Adaptation In Chronic Pain: Predicting Pain Intensity And Interference, Paria Eshraghi, Deirdre Drake, Joanne Iddon, Joanne M. Dickson

Research outputs 2022 to 2026

Chronic pain is a major public health concern associated with disability, reduced functioning and psychological distress. Compared with biological studies, relatively little research has studied chronic pain from a psychological perspective, specifically motivation. Yet, motivation is considered fundamental to human functioning and drives human behaviour. The present study aimed to investigate whether distinct motivational and adaptive goal processes are implicated in chronic pain. The sample comprised 190 adult community participants who reported chronic pain for 3 months or more. Participants completed self-report measures of approach and avoidance motivation, adaptive goal processes, pain intensity, and interference. As hypothesised, avoidance motivation (but …

Protective Potential Of Minimally Processed, Plant-Derived Foods Against Steatotic Liver Disease In Early Adulthood, Yasmina Tashkent, Jocelyn M. Choo, Steven L. Taylor, Therese A. O'Sullivan, Dujinthan Jayabalan, Sophie J. Miller, Richard Woodman, Luis Calzadilla-Bertot, Oyekoya T. Ayonrinde, Lawrence J. Beilin, Trevor A. Mori, John K. Olynyk, Alan J. Wigg, Kate R. Muller, Leon A. Adams, Geraint B. Rogers

Research outputs 2022 to 2026

Background & aims: The incidence of steatotic liver disease (SLD) among younger adults is increasing globally. While poor diet is a recognised risk factor, the impact of specific dietary components is unclear. We investigated associations between dietary patterns and SLD markers in younger adults. Methods: Analysis involved 887 members of the Raine Study Generation 2 cohort, assessed at age 27. SLD was defined using a validated MRI volumetric liver fat fraction equation. Dietary intake, assessed by food frequency questionnaires, was summarised using a modified Overall Diet Score (ODS) that classified foods as “healthy” or “unhealthy.” Associations between diet and SLD …

Precision Nutrition In Breast Cancer: Towards Patient- And Tumour-Informed Dietary Strategies, Cristina Crespo-García, R. Taaffe, Carolyn Peddle-Mcintyre, Emily Jeffery, John P. Campbell, Robert Thomas, Daniel A. Galvao, Robert U. Newton

Research outputs 2022 to 2026

Dietary strategies are increasingly recognized as important modulators of breast cancer outcomes, acting through effects on metabolic regulation, weight management, hormone signalling, immune function, and the gut microbiome. However, breast cancer heterogeneity and inter-individual variability mean that generic dietary guidelines may not fully capture patient needs. Precision nutrition offers the opportunity to align dietary interventions with tumour subtype, treatment context, and host biology, potentially enhancing therapeutic response and survivorship in patients diagnosed with breast cancer. In this narrative review, we summarize evidence on dietary patterns and prognosis, and explore how targeted interventions, including fasting regimens, ketogenic diets, and caloric restriction, …

Shape-Based Profiling Of Cortical Bone Mineral Density In Growing Children: A Proof-Of-Concept Pqct Study, Anna Maria Markarian, R. Taaffe, Daniel Galvão, Jodie Cochrane Wilkie, Carolyn J. Peddle-Mcintyre, Daniel J. Schiferl, Robert U. Newton

Research outputs 2022 to 2026

Background: Understanding how bones adapt during growth is essential for promoting lifelong skeletal health. Peripheral quantitative computed tomography (pQCT) is a widely used imaging technique for assessing volumetric bone mineral density (vBMD) in pediatric populations; however, conventional methods may obscure subtle cortical adaptations. The primary aim of this study was to evaluate the feasibility of shape-based cortical vBMD profiling, with an exploratory objective of assessing its sensitivity to inter-individual variation in lean mass index (LMI). Methods: Eighteen children (6–12 years) underwent pQCT scanning at the 38% and 66% tibial sites (distal and proximal diaphysis). Cortical vBMD was quantified across three …

The Effect Of Vigorous Physical Activity On The Incidence Of Kidney Cancer, Lawrence H. Kim, Bang, Daniel Galvao, David P. Smith, Manish I. Patel

Research outputs 2022 to 2026

Background: Kidney cancer incidence is increasing. While physical activity can reduce the risk of several cancers, the role of vigorous physical activity (VPA) in kidney cancer prevention remains unclear. We examined associations between physical activity intensity and kidney cancer incidence in a large Australian cohort. Methods: Data were obtained from 267,357 adults aged ≥ 45 years in the New South Wales 45 and Up Study. Physical activity, including walking, moderate physical activity (MPA), and VPA, was self-reported at baseline using the validated Active Australia Survey and categorised according to WHO guidelines. Multivariable Cox proportional hazards models estimated hazard ratios and …

Multi-Sensory Information And Simulator Immersion: Impact On Decision-Making Performance, Presence, And Cognitive Load, Zachariah G. Hoyne, Khaya Morris-Binelli, Sean Müller, Benjamin Piggott, Paola Chivers, Evan Dekker

Research outputs 2022 to 2026

Immersive technologies such as 360-degree video virtual reality (360VR) provide unique opportunities to simulate representative environments to investigate decision-making in a safe and cost-effective manner. Inclusion of multi-sensory visual, contextual, and auditory information is important to enhance simulator psychological fidelity. Yet, the influence of increased sensory information on decision-making, presence, and cognitive load in 360VR compared to less immersive two-dimensional video simulators is unknown. This study investigated multi-sensory information, presence, and cognitive load across immersion conditions (360VR and two-dimensional video) in an exemplar sport-specific decision-making task. Fifteen higher-skilled and 15 lesser-skilled Australian Rules Football players completed a decision-making task which …