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Pfas Quantification Using Solid Phase Extraction And Low Field Nuclear Magnetic Resonance (Spe-Nmr), Nicholas N.A. Ling, Ghasemi, Ella Shilliday, Masoumeh Zargar, Einar Fridjonsson, Michael L. Johns Jul 2026

Pfas Quantification Using Solid Phase Extraction And Low Field Nuclear Magnetic Resonance (Spe-Nmr), Nicholas N.A. Ling, Ghasemi, Ella Shilliday, Masoumeh Zargar, Einar Fridjonsson, Michael L. Johns

Research outputs 2022 to 2026

Per- and polyfluoroalkyl substances (PFAS) are synthetic chemicals that are highly resistant to biodegradation. Due to their bioaccumulation, long-term persistence, and adverse human health effects, they have been classified as organic pollutants. The leaching of PFAS into water sources has resulted in their detection in global drinking water supplies. To mitigate adverse health effects and minimise environmental damage, regulations regarding maximum allowable PFAS concentrations in water have been imposed. Traditional PFAS in water quantification methods, such as liquid chromatography–mass spectrometry (LC–MS), gas chromatography–mass spectrometry (GC–MS), and high-performance liquid chromatography (HPLC), have intrinsic limitations that pose challenges in such PFAS analysis. …


More Than Just Fair: Legitimizing Ai Through Reciprocity, Ethical Ai Characteristics And Personal Information Sharing, Shahid Hussain, Asim Qazi, Violetta Wilk Jul 2026

More Than Just Fair: Legitimizing Ai Through Reciprocity, Ethical Ai Characteristics And Personal Information Sharing, Shahid Hussain, Asim Qazi, Violetta Wilk

Research outputs 2022 to 2026

This research examines how perceived reciprocity and perceived ethical AI characteristics – fairness, accountability, and transparency (FAT principles) – shape consumers’ willingness to share personal information and its downstream consequences in AI-mediated consumer-brand interactions. Grounded in social exchange theory, we conceptualize personal information sharing as a behavioral gateway through which ethical exchange cues translate into perceived algorithmic legitimacy and intention to co-create value. Using a two-study design, consisting of a scenario-based experiment (n = 184) and a cross-sectional survey (n = 612), the findings of this research show that reciprocity and FAT principles robustly increase willingness to share personal information. …


Cognitive Decline In Dutch-Type Hereditary And Sporadic Cerebral Amyloid Angiopathy: A 5-Year Follow-Up Study, Rosemarie Van Dort, Vera C.J. Van Stek-Smits, Sanne E. Schriemer, Reinier G.J. Van Der Zwet, Manon R. Schipper, Sabine Voigt, Ellen P. Hart, Vandhana Easwaran, Hamid R. Sohrabi, Kevin Taddei, Samantha L. Gardener, Ralph N. Martins, Steven M. Greenberg, Matthias J.P. Van Osch, Marianne A.A. Van Walderveen, Marieke J.H. Wermer, Ellis S. Van Etten Jul 2026

Cognitive Decline In Dutch-Type Hereditary And Sporadic Cerebral Amyloid Angiopathy: A 5-Year Follow-Up Study, Rosemarie Van Dort, Vera C.J. Van Stek-Smits, Sanne E. Schriemer, Reinier G.J. Van Der Zwet, Manon R. Schipper, Sabine Voigt, Ellen P. Hart, Vandhana Easwaran, Hamid R. Sohrabi, Kevin Taddei, Samantha L. Gardener, Ralph N. Martins, Steven M. Greenberg, Matthias J.P. Van Osch, Marianne A.A. Van Walderveen, Marieke J.H. Wermer, Ellis S. Van Etten

Research outputs 2022 to 2026

Introduction: Cerebral amyloid angiopathy (CAA) is associated with cognitive impairment, but its longitudinal course of cognitive decline remains unclear. We investigated domain-specific cognitive trajectories in Dutch-type hereditary (D-CAA) and sporadic CAA (sCAA) to compare patterns and rates of decline. Methods: We included 181 participants – 93 D-CAA mutation carriers (59 without, 34 with prior intracerebral hemorrhage [ICH]) and 88 with sCAA (57 without, 31 with ICH) – who underwent annual neuropsychological assessment. Longitudinal change in global cognition, memory, processing speed, and executive function was analyzed using linear mixed models. Results: Over 5 years, cognitive decline was subtle but measurable. Memory …


The Effect Of Cyp1a2 Gene Polymorphisms On Caffeine Pharmacokinetics And Exercise Performance In Male Recreational Athletes, Chloe Masters, Ajmol Ali, Claire Badenhorst, Martin Dickens, Kay Rutherfurd-Markwick Jul 2026

The Effect Of Cyp1a2 Gene Polymorphisms On Caffeine Pharmacokinetics And Exercise Performance In Male Recreational Athletes, Chloe Masters, Ajmol Ali, Claire Badenhorst, Martin Dickens, Kay Rutherfurd-Markwick

Research outputs 2022 to 2026

This study examined the effects of caffeine consumption on endurance exercise performance, and the influence of CYP1A2 gene polymorphisms in caffeine pharmacokinetics and exercise performance. The data sets of two randomised, double blind, placebo-controlled crossover study design experiments have been merged. Thirty-eight recreationally active male participants provided saliva samples for CYP1A2 genotyping (AA homozygotes n = 19; AC heterozygotes n = 19) and completed either a 10-km run or 40-km cycling time trial of 60-min following a single dose of 6 mg·kg−1 caffeine (CAF) or placebo (maltodextrin; PLA) throughout which heart rate (HR) and time to completion (TTC) were …


Impact Of Capillary Imbibition On Development Of Unconventional Oilfields: A Five-Year Review, Yihang Xiao, You, Yongming He, Han Xu, Lei Wang, Yujie Yuan Jul 2026

Impact Of Capillary Imbibition On Development Of Unconventional Oilfields: A Five-Year Review, Yihang Xiao, You, Yongming He, Han Xu, Lei Wang, Yujie Yuan

Research outputs 2022 to 2026

The imbibition process, which is characterized by the displacement of non-wetting phase by wetting phase in porous media, plays a crucial role in enhancing oil recovery of unconventional reservoirs. However, due to the complex nature of reservoir characteristics and fluid properties, existing research on this phenomenon presents contradictory conclusions and interpretations. This paper aims to fill this knowledge gap by providing a comprehensive review of the fundamental concepts, primary mechanical factors, and critical influences in oil-water imbibition. Primary mechanisms, including capillary, viscous, gravitational, hydrostatic, inertial, capillary back, dead end, and osmotic forces, are analyzed in terms of their key roles …


Why Are Western Australian Girls Less Motivated Than Boys To Study Senior Secondary Higher-Level Mathematics Courses? Relationships Between Gender, Prior Achievement, And Mathematics Course Aspirations, Jane Kirkham, Elaine Chapman Jul 2026

Why Are Western Australian Girls Less Motivated Than Boys To Study Senior Secondary Higher-Level Mathematics Courses? Relationships Between Gender, Prior Achievement, And Mathematics Course Aspirations, Jane Kirkham, Elaine Chapman

Research outputs 2022 to 2026

Secondary school students, and particularly girls, may avoid enrolling in higher-level mathematics courses despite having the competence to succeed in these courses. Understanding the reasons behind these choices is essential to addressing this concern. In this study, the teachers of Western Australian Year 10 students (n=886) nominated the mathematics course in which they believed each participating student could succeed in Year 11 with participants grouped into four achievement cohorts on this basis. Then each teacher course nomination was compared to participants’ own course selection with participants classified as either aspiring below or at/above their judged potential achievement level. We then …


A Scalable Workflow Using Digital Cognitive Assessment And Ptau217 For Mci Detection, Srinivasan Vairavan, Nicholas Griffin, David Wilson, Gallen Triana-Baltzer, Victoria Brugada-Ramentol, Elena Vera-Campuzano, Daniel Alcolea, Silvia Fallone, Lucy Mackintosh, Lindsey Mette, James D. Doecke, Joanne Robertson, Larry Ward, Gonzalo Sánchez Benavides, Carolina Minguillon, Clàudia Porta Mas, Adrià Tort-Merino, Mircea Balasa, Oriol Grau Rivera, Marc Suárez Calvet, Lewis Taylor Jul 2026

A Scalable Workflow Using Digital Cognitive Assessment And Ptau217 For Mci Detection, Srinivasan Vairavan, Nicholas Griffin, David Wilson, Gallen Triana-Baltzer, Victoria Brugada-Ramentol, Elena Vera-Campuzano, Daniel Alcolea, Silvia Fallone, Lucy Mackintosh, Lindsey Mette, James D. Doecke, Joanne Robertson, Larry Ward, Gonzalo Sánchez Benavides, Carolina Minguillon, Clàudia Porta Mas, Adrià Tort-Merino, Mircea Balasa, Oriol Grau Rivera, Marc Suárez Calvet, Lewis Taylor

Research outputs 2022 to 2026

Introduction: Blood biomarkers like phosphorylated tau (p-tau)217 offer high diagnostic accuracy for Alzheimer's disease (AD) but face implementation challenges in low-prevalence settings. We evaluated the Altoida NeuroMarker Platform as a digital cognitive triage tool before plasma p-tau217 testing.

Methods: XGBoost models were trained to predict mild cognitive impairment (MCI) and p-tau217 status in 688 individuals across Australia, Spain, and the United States using the Altoida NeuroMarker. p-tau217 status was dichotomized using a threshold of 0.04 pg/mL (LucentAD). We modeled a two-step workflow (Altoida, plasma p-tau217) to enrich downstream biomarker testing, assuming 30% prevalence of AD pathology.

Results: The Altoida NeuroMarker …


Do I Fit In Here? How Immigrants’ Endorsement Of Social Markers Is Related To Their Wellbeing In Three Migrant Receiving Societies, Justine Dandy, Chan Hoong Leong, Adam Komisarof, Travis Lim, Krystal Perkins Jul 2026

Do I Fit In Here? How Immigrants’ Endorsement Of Social Markers Is Related To Their Wellbeing In Three Migrant Receiving Societies, Justine Dandy, Chan Hoong Leong, Adam Komisarof, Travis Lim, Krystal Perkins

Research outputs 2022 to 2026

Social markers of acceptance are the attributes seen as important for immigrants to achieve or display in order to be accepted similarly to a local-born citizen. In research on constructions of national identity, factor analysis reveals a culture-specific, two-factor structure akin to the ethnic–civic distinction observed. In this paper, we extend this work by examining the relationship between social markers of acceptance and immigrants’ well-being in three national contexts: Australia, Japan, and the U.S. Specifically, in study 1 we examined the factor structure of social markers in non-immigrant samples in each context (Australia, n = 1357; Japan, n = 2000; …


Nursing Students' Evaluation Of Primary Health Care Clinical Placements - A Cross-Sectional Study, Debbie Procter, Megan Lee, Debbie Massey, Kylie Mccullough, Karen Strickland Jul 2026

Nursing Students' Evaluation Of Primary Health Care Clinical Placements - A Cross-Sectional Study, Debbie Procter, Megan Lee, Debbie Massey, Kylie Mccullough, Karen Strickland

Research outputs 2022 to 2026

Aim: Evaluate quality and satisfaction of nursing students' Primary Health Care clinical placements. Background: There is growing recognition of the need to expand the Primary Health Care nursing workforce, with positive clinical placement experiences considered essential for preparing and inspiring future careers in these settings; however, few graduate nurses choose this career path. Design: A cross-sectional study design using purposive sampling. Participants: Data were sourced from National Placement Evaluation Centre's 2023/2024 dataset using the validated PET–Nursing survey. The tool includes 20 items across two subscales - Clinical Environment and Learning Support, with the final item assessing overall placement satisfaction. Surveys …


The Effects Of Anti-Parkinsonian Medications On Bone Mineral Density: A Systematic Review, Mícheál Ó Breasail, Motaz B. El-Leissy, Karan P. Singh, Matthew Smith, Jakub Mesinovic, Marc Sim, Andrew Evans, David Blacker, Saman Heshmat, Neil Mahant, Christian Girgis, Peter R. Ebeling, Ayse Zengin Jul 2026

The Effects Of Anti-Parkinsonian Medications On Bone Mineral Density: A Systematic Review, Mícheál Ó Breasail, Motaz B. El-Leissy, Karan P. Singh, Matthew Smith, Jakub Mesinovic, Marc Sim, Andrew Evans, David Blacker, Saman Heshmat, Neil Mahant, Christian Girgis, Peter R. Ebeling, Ayse Zengin

Research outputs 2022 to 2026

IntroductionParkinson's disease (PD) is associated with elevated fracture risk, particularly at the hip. Antiparkinsonian medications have also been associated with increased fracture risk; although their direct effects on bone mineral density (BMD) remains unclear.ObjectiveInvestigate whether antiparkinsonian medications influence BMD.MethodsA systematic search of four databases (Embase, MEDLINE, APA PsycINFO, Web of Science) was conducted up to 24/11/2025 using terms related to PD, antiparkinsonian medications and bone.ResultsA total of 748 records were identified, with 543 screened following deduplication. Fourteen studies underwent full-text review, of which seven met inclusion criteria. Three studies assessed bone mineral content or surrogate measures at non-standard sites (hand …


Sagittal Abdominal Diameter And Abdominal Aortic Calcification Are Associated With Incident Major Adverse Cardiovascular Events: The Manitoba Bone Density Registry, Haftom N. Abraha, Abadi K. Gebre, Marc Sim, Cassandra Smith, Syed Zulqarnain Gilani, Zaid Ilyas, Fatima Zarzour, John T. Schousboe, Lisa M. Lix, Neil Binkley, Siobhan Reid, Barret A. Monchka, Douglas Kimelman, Joshua R. Lewis, William D. Leslie Jul 2026

Sagittal Abdominal Diameter And Abdominal Aortic Calcification Are Associated With Incident Major Adverse Cardiovascular Events: The Manitoba Bone Density Registry, Haftom N. Abraha, Abadi K. Gebre, Marc Sim, Cassandra Smith, Syed Zulqarnain Gilani, Zaid Ilyas, Fatima Zarzour, John T. Schousboe, Lisa M. Lix, Neil Binkley, Siobhan Reid, Barret A. Monchka, Douglas Kimelman, Joshua R. Lewis, William D. Leslie

Research outputs 2022 to 2026

BackgroundSagittal abdominal diameter (SAD), a measure of visceral adiposity, has been linked to major adverse cardiovascular events (MACE). However, the relationship between SAD and abdominal aortic calcification (AAC), a marker of subclinical vascular disease, and whether they independently and jointly predict MACE remains unclear.ObjectiveTo investigate whether weight-normalized SAD and AAC scored using a validated machine learning algorithm (ML-AAC24) are independently and jointly associated with incident MACE.MethodsSAD and ML-AAC24 were measured from dual-energy X-ray absorptiometry (DXA) posteroanterior and lateral spine images, respectively, from the Manitoba Bone Density registry.ResultsAmong 8806 individuals (mean age 75.1 ± 6.6 years, 93.9% women), 11.3% experienced MACE …


Dimpled Surfaces For Thermal Performance Enhancement In Solar Collectors, Furqan Jamil, Baig, Amna Adil, Aasia Farrukh Jul 2026

Dimpled Surfaces For Thermal Performance Enhancement In Solar Collectors, Furqan Jamil, Baig, Amna Adil, Aasia Farrukh

Research outputs 2022 to 2026

With escalating environmental concerns, solar energy is a feasible approach to support a sustainable environment, considering the pressing need to move away from fossil fuels. Optimizing solar collector’s efficiency improves energy capture and lowers carbon emissions. One innovative technique is to the surface of solar collectors. The heat transfer is greatly increased by adding such tiny indentations, encouraging turbulence in the incoming working fluid. The article reviews the effect of dimples on the efficiency of various collector applications, including flat plate collector, solar water heaters, solar air collectors, parabolic trough solar collectors, photovoltaic thermal systems, desalination, and many others. The …


The Impact Of Hypertensive Disorders Of Pregnancy On Cognitive Outcomes In Offspring: Systematic Review And Meta-Analysis, Berihun Dachew, Tusa, Getinet Ayano, Kim Betts, Amanuel Gebremedhin, Daniel Rudaizky, Gizachew A. Tessema, Rosa Alati Jul 2026

The Impact Of Hypertensive Disorders Of Pregnancy On Cognitive Outcomes In Offspring: Systematic Review And Meta-Analysis, Berihun Dachew, Tusa, Getinet Ayano, Kim Betts, Amanuel Gebremedhin, Daniel Rudaizky, Gizachew A. Tessema, Rosa Alati

Research outputs 2022 to 2026

Purpose To synthesis the available research on the association between hypertensive disorders during pregnancy (HDP) and adverse cognitive outcomes in children. Methods PubMed, MEDLINE, Embase, Scopus, CINAHL, and PsycInfo were searched from inception to February 2026 to identify relevant studies. Effect estimates and 95% confidence intervals (CIs) were extracted and pooled using inverse variance–weighted random-effects meta-analysis. Results Thirty-nine observational studies published between 1982 and 2026, covering over 12.5 million mother-offspring pairs, were included in the final analysis. The findings indicate that HDP were associated with a 39% increased risk of Intellectual Disability (ID) (OR = 1.39, 95% CI = 1.30–1.47) …


Effect Of Anisotropic Hydraulic Conductivity On Groundwater Seepage Into A Rectangular Tunnel In Submerged Sand, Deki Yangzom Ghaley, Sanjay Kumar Shukla Jul 2026

Effect Of Anisotropic Hydraulic Conductivity On Groundwater Seepage Into A Rectangular Tunnel In Submerged Sand, Deki Yangzom Ghaley, Sanjay Kumar Shukla

Research outputs 2022 to 2026

Managing groundwater seepage around tunnels is critical to tunnel design, particularly when the tunnel is constructed below the water table. Accurate seepage flow patterns and water inflow prediction under ordinary and critical conditions are imperative to mitigate potential tunnel construction and service disasters. In the past, an in-depth study on the anisotropic hydraulic conductivity of the soil mass that may affect the seepage condition has not been carried out. In this work, this aspect has been investigated numerically for a rectangular tunnel submerged within a homogeneous sand mass, considering the anisotropic hydraulic conductivity ratio (kz / kx, kz = vertical …


Advancing Dimensional Models Of Psychopathology In Cancer: Insights From Applying The Hierarchical Taxonomy Of Psychopathology (Hitop), Darren Haywood, Jai Carmichael, Miriam K. Forbes, Roman Kotov, Robert F. Krueger, Aidan G.C. Wright, Susan L. Rossell, David Castle, Wendy Lam, Maryam Lustberg, Colin E. Vize, Anna Ugalde, Phyllis Butow, Nicolas H. Hart Jul 2026

Advancing Dimensional Models Of Psychopathology In Cancer: Insights From Applying The Hierarchical Taxonomy Of Psychopathology (Hitop), Darren Haywood, Jai Carmichael, Miriam K. Forbes, Roman Kotov, Robert F. Krueger, Aidan G.C. Wright, Susan L. Rossell, David Castle, Wendy Lam, Maryam Lustberg, Colin E. Vize, Anna Ugalde, Phyllis Butow, Nicolas H. Hart

Research outputs 2022 to 2026

Objective: Cancer survivors, defined as those living with or beyond a cancer diagnosis, experience more than double the prevalence of psychopathology when compared to the general population. Categorical diagnostic systems, such as the Diagnostic and Statistical Manual of Mental Disorders (DSM), remain dominant in psycho-oncology despite concerns about reliability, validity, and clinical utility for this population. Dimensional frameworks, such as the Hierarchical Taxonomy of Psychopathology (HiTOP), offer a more precise alternative; however, they have not yet been widely applied in cancer survivors. Accordingly, the objective of this research was to examine the applicability of HiTOP to cancer survivors. Methods: Data …


Artificial Intelligence Based Predictive Simulation And Decision-Support Framework For Full Scale Wastewater Treatment Systems, Muhammad Hassnain, Cameron Veal, Sarada M.W. Lee, Muhammad Rizwan Azhar Jul 2026

Artificial Intelligence Based Predictive Simulation And Decision-Support Framework For Full Scale Wastewater Treatment Systems, Muhammad Hassnain, Cameron Veal, Sarada M.W. Lee, Muhammad Rizwan Azhar

Research outputs 2022 to 2026

Full scale wastewater treatment plants (WWTPs) generate extensive sensor and laboratory datasets that remain challenging to translate into real-time operational insight, while increasing hydraulic variability, energy constraints, tightening effluent regulations, and events such as sensor faults, hydraulic shocks, and effluent-quality excursions require predictive decision-support tools beyond conventional mechanistic modelling. This study presents a full-scale, industry-deployed artificial intelligence (AI) framework integrating machine learning (ML), simulation, and operational boundary definition across a nitrogen-removal WWTP in Australia. Up to nine years of high-frequency online instrumentation data (≤419,000 records per target; 5–30 min resolution) and ~3000 laboratory samples were used to train and evaluate …


Digital Teaching In Midwifery Education Since 2021: A Literature Review Of Trends, Technological Advancements And Challenges, Michelle Gray, Kristina Vogel, Annette Bernloehr, Terri Downer, Melanie Welfare, Nicola H. Bauer Jul 2026

Digital Teaching In Midwifery Education Since 2021: A Literature Review Of Trends, Technological Advancements And Challenges, Michelle Gray, Kristina Vogel, Annette Bernloehr, Terri Downer, Melanie Welfare, Nicola H. Bauer

Research outputs 2022 to 2026

Aim: To produce an updated synthesis of digital learning and teaching approaches in midwifery education since 2021. Background: Globally, there is an increasing trend towards using digital technologies in midwifery education with little examination of trends, terminology or impact by midwifery academics. Design: A comprehensive literature review. Methods: Ten databases were searched (2021–March 2025) guided by JBI methodology and PRISMA-ScR reporting, resulting in 36 empirical studies focusing on digital technologies used with midwifery students. The review mapped recent technological developments, associated benefits and emerging challenges. Results: Digital innovations were in 15 countries and ranged from immersive virtual reality, augmented and …


Does Poor Regulation Lead To Pollution? Key Takeaways From A Systematic Review, Vincent Emenyonu, Kat O. Mara, Mark Lund Jul 2026

Does Poor Regulation Lead To Pollution? Key Takeaways From A Systematic Review, Vincent Emenyonu, Kat O. Mara, Mark Lund

Research outputs 2022 to 2026

Formal recycling of used lead acid batteries (ULAB) is a multibillion-dollar industry, valued at US$12.12 billion in 2024, and expected to grow to more than $26 billion within eight years. Demand for recycled lead (Pb) for new batteries grows in developing countries where costs limit the uptake of lithium-ion batteries. ULAB recycling in these regions poses significant danger to human health and the environment. Stringent regulatory approaches for ULAB recycling in developing countries, intended to reduce pollution, have thus far been ineffective as they typically do not adequately cover small-scale informal recycling in rural and remote communities. We examine what …


Effects Of Obstructive Sleep Apnea On Circulating Immune Cells Profiles: Evidence From Nhanes Dataset And Mendelian Randomization, Yajie Jia, Xiang Gao, Shenglong Xu, Jingli Shi, Haifeng Hou, Yanru Li, Demin Han Jul 2026

Effects Of Obstructive Sleep Apnea On Circulating Immune Cells Profiles: Evidence From Nhanes Dataset And Mendelian Randomization, Yajie Jia, Xiang Gao, Shenglong Xu, Jingli Shi, Haifeng Hou, Yanru Li, Demin Han

Research outputs 2022 to 2026

Objectives: This study aimed to investigate the impact of Obstructive Sleep Apnea (OSA) on immune cell profiles by utilizing both the National Health and Nutrition Examination Survey (NHANES) dataset and a two-sample Mendelian Randomization (MR) method. Methods: We included 20,732 participants from the NHANES to explore the relationship between symptom defined OSA and peripheral immune cells. Additionally, we conducted a two-sample MR analysis to investigate the effect of OSA on 35 summarized peripheral immune cell properties and 731 immunophenotypes. To ensure the robustness of findings in MR analysis, we conducted a sensitivity analysis. Results: The NHANES dataset and MR analysis …


From Hermeneutic Theory To Pedagogical Practice: Dialogue, Fusion Of Horizons, And Tradition In The Philosophy For Children Classroom, Leon Benade Jul 2026

From Hermeneutic Theory To Pedagogical Practice: Dialogue, Fusion Of Horizons, And Tradition In The Philosophy For Children Classroom, Leon Benade

Research outputs 2022 to 2026

This article brings Hans-Georg Gadamer’s philosophical hermeneutics into critical conversation with the pedagogical practice of philosophy in schools, focusing particularly on Philosophy for Children (P4C). While P4C offers a rich pedagogical model for developing reasonableness through the Community of Inquiry (CoI), its account of the conditions under which understanding occurs remains somewhat underdeveloped. Although some scholars have situated P4C in relation to hermeneutics, this engagement is limited. Addressing this gap, the key Gadamerian ideas of tradition, prejudice, and the fusion of horizons and dialogue are explored here to deepen and extend the theoretical considerations of inquiry in P4C. The discussion …


Inpatient Versus Outpatient Management Of Bilateral Optic Nerve Head Elevation Presentation To A Tertiary Emergency Department, Mengchen Suo, Johnny Lo, Fred K. Chen Jul 2026

Inpatient Versus Outpatient Management Of Bilateral Optic Nerve Head Elevation Presentation To A Tertiary Emergency Department, Mengchen Suo, Johnny Lo, Fred K. Chen

Research outputs 2022 to 2026

Introduction: Increased accessibility to fundus cameras has changed the referral pattern for patients with suspected bilateral optic nerve head elevation (BONHE) presenting to emergency departments (EDs). We aim to review the management of these patients to streamline the process. Methods: A retrospective review of patients with suspected BONHE referred to a tertiary centre ED between 2017 and 2022. We collected demographics, referral source, clinical assessment, neuroimaging and retinal imaging results. Final diagnosis and treatment outcomes were compared between those managed as inpatients and those managed as outpatients. Results: 100 patients were referred to the ED with a suspected BONHE. Most …


Integrative Oncology For Prostate Cancer: A Narrative Review, Kevin T. Liou, Nicole A. Metri, Robert U. Newton, Divya Ajay, Eleanor M. Walker, Channing J. Paller Jul 2026

Integrative Oncology For Prostate Cancer: A Narrative Review, Kevin T. Liou, Nicole A. Metri, Robert U. Newton, Divya Ajay, Eleanor M. Walker, Channing J. Paller

Research outputs 2022 to 2026

Prostate cancer is most common malignancy among men in the United States. As men are now living longer with prostate cancer due to advances in treatment, there exists a growing need to manage the long-term physical and psychological sequelae of this disease, which range from genitourinary dysfunction to cardiometabolic and psychosocial consequences. Over half of men with prostate cancer report unmet needs in symptom management. Integrative oncology, a patient-centered, evidence-informed field combining lifestyle, natural product, and mind–body interventions with conventional treatments, offers a promising approach to prostate cancer symptom management. This review summarizes the current landscape of integrative oncology research …


Neuroprotective Effects Of Sorghum Polyphenol In Alzheimer’S Disease: In Vitro And In Silico Analyses, Rasheed A. Abdulraheem, Ralph N. Martins, Rajapandiyan Krishnamoorthy, Mohammad A. Alshuniaber, Prashant Bharadwaj, Zhaoyu Li, Ranil Coorey, Vijay Jayasena, Stuart K. Johnson, W. M.A.D.Binosha Fernando Jul 2026

Neuroprotective Effects Of Sorghum Polyphenol In Alzheimer’S Disease: In Vitro And In Silico Analyses, Rasheed A. Abdulraheem, Ralph N. Martins, Rajapandiyan Krishnamoorthy, Mohammad A. Alshuniaber, Prashant Bharadwaj, Zhaoyu Li, Ranil Coorey, Vijay Jayasena, Stuart K. Johnson, W. M.A.D.Binosha Fernando

Research outputs 2022 to 2026

Background/Objective: Accumulation of amyloid-beta (Aβ) senile plaques in the human brain is a major hallmark of Alzheimer’s disease (AD), which manifests as progressive decline in memory and cognitive functions and currently lacks effective disease-modifying therapies. Emerging evidence demonstrates that polyphenol-rich plant foods are potential complementary therapies for AD. Methods: In this study, we investigated crude polyphenol extracts (CPEs) and purified polyphenol extracts (PPEs) from three sorghum genotypes for their ability to inhibit Aβ42-induced toxicity in MC-65 cells. Thioflavin T fluorescence, cell viability, mitochondrial function, oxidative stress assays, and Western blotting, along with RNA sequencing and computational analyses, were used to …


Predicting Accumulation And Age At Onset Of Amyloid-Β From Genetic Risk And Resilience For Alzheimer's Disease, Eleanor K. O'Brien, Timothy Cox, Shane Fernandez, Pierrick Bourgeat, Tenielle Porter, Ben Goudey, James D. Doecke, Colin L. Masters, Jurgen Fripp, Kwangsik Nho, Victor L. Villemagne, Carlos Cruchaga, Christopher C. Rowe, Andrew J. Saykin, Vincent Doré, Simon M. Laws Jul 2026

Predicting Accumulation And Age At Onset Of Amyloid-Β From Genetic Risk And Resilience For Alzheimer's Disease, Eleanor K. O'Brien, Timothy Cox, Shane Fernandez, Pierrick Bourgeat, Tenielle Porter, Ben Goudey, James D. Doecke, Colin L. Masters, Jurgen Fripp, Kwangsik Nho, Victor L. Villemagne, Carlos Cruchaga, Christopher C. Rowe, Andrew J. Saykin, Vincent Doré, Simon M. Laws

Research outputs 2022 to 2026

Background: Accumulation of brain amyloid beta (Aβ), a key pathological hallmark of Alzheimer's disease (AD), begins decades before cognitive symptoms. Being able to predict the risk of Aβ accumulation, or the age at which Aβ exceeds a critical threshold, may enable intervention to delay or prevent onset of AD. Methods: Using published genome-wide association studies (GWASs), we developed polygenic scores (PGS) for AD risk (PGSrisk) and resilience (PGSresilience), and tested whether these predicted (i) if an individual is an Aβ accumulator (‘Accumulator Status’), and (ii) in accumulators, the age at which brain Aβ exceeds a 20 centiloid (CL) threshold (‘Age …


Regional Homeschool Children’S Experience With Arts-Based Digital Literacy Workshops, Kimberly Maslin, Karen Murcia, Jane Mulcock Jul 2026

Regional Homeschool Children’S Experience With Arts-Based Digital Literacy Workshops, Kimberly Maslin, Karen Murcia, Jane Mulcock

Research outputs 2022 to 2026

The number of children engaged in homeschool education is increasing, particularly in regional areas of Australia. Homeschool families currently access community-based activities such as theatre productions and sports programs, as well as public library services, to enrich their children’s learning. However, access to quality programs that support digital literacy skills remains limited and the benefits of these programs to home schoolers remain largely unexplored. This study examined the experiences of homeschool families with children aged 6–12 who participated in a series of stop-motion animation workshops held in a regional Western Australian public library. Data were collected from both participating parents …


Semantic Context Improvisational Retrieval-Augmented Generation For Empathic Conversational Ai, Sharjeel Tahir, Judith Johnson, Jumana Abu-Khalaf, Syed Afaq Ali Shah Jul 2026

Semantic Context Improvisational Retrieval-Augmented Generation For Empathic Conversational Ai, Sharjeel Tahir, Judith Johnson, Jumana Abu-Khalaf, Syed Afaq Ali Shah

Research outputs 2022 to 2026

A fundamental limitation of modern conversational AI is its limited capacity to demonstrate sustained empathy in long-form interactions. We propose SCIRAG (Semantic Context Improvisational Retrieval-Augmented Generation), a feedback-driven retrieval framework for adaptive empathic dialogue. It employs a dual-loop retrieval framework, iteratively optimizing a static counseling dataset through user metadata and feedback memory refinement. To enhance contextual alignment, we deploy retrieval adaptation, enabling the model to retain and leverage past conversational cues based on user preferences. When integrated with Mixtral-8x7B, SCIRAG improves human-rated empathic understanding by +1.26 points and empathic response by +1.00 point on the RoPE scale, while increasing acceptability …


Sliding Mode Control In Grid-Tied Inverters: Techniques, Applications, And Future Directions, Taimoor Muzaffar Gondal, Asma Aziz, Daryoush Habibi, Iftekhar Ahmad Jul 2026

Sliding Mode Control In Grid-Tied Inverters: Techniques, Applications, And Future Directions, Taimoor Muzaffar Gondal, Asma Aziz, Daryoush Habibi, Iftekhar Ahmad

Research outputs 2022 to 2026

Sliding mode control (SMC) has emerged as a robust and adaptive strategy for grid-tied inverters. It has unique attributes which make it an appropriate control choice under increasingly complex power systems. However, there are a limited number of review articles which comprehensively explore the true potential of SMC for grid-tied inverter applications. This systematic review has been structured to explore SMC techniques with respect to certain challenges, i.e., stability challenges, unbalanced conditions, low inertia scenarios, and harmonics distortion. The classification of various SMC techniques is presented with respect to their control law and sliding surfaces design. The comparative analysis indicates …


The Contribution Of Adolescent Cardiovascular Disease Risk Factors To Vascular Stiffness And Cardiac Remodelling In Young Adults, Anne E. Barden, Lawrence J. Beilin, Nick S.R. Lan, Amro Sehly, Girish Dwivedi, Rae-Chi Huang, Brendan Adler, Trevor A. Mori Jul 2026

The Contribution Of Adolescent Cardiovascular Disease Risk Factors To Vascular Stiffness And Cardiac Remodelling In Young Adults, Anne E. Barden, Lawrence J. Beilin, Nick S.R. Lan, Amro Sehly, Girish Dwivedi, Rae-Chi Huang, Brendan Adler, Trevor A. Mori

Research outputs 2022 to 2026

Aims: Early identification of abnormalities in vascular and cardiac structure offers an opportunity for intervention to reduce future cardiovascular disease (CVD). This study examined factors contributing to increased CVD risk from adolescence to young adulthood. Methods and results: Raine Study participants (n = 716) classified as low- or high-CVD risk using cluster analysis at 17 years were re-studied at 27 years. Outcomes at 27 years were vascular stiffness assessed by pulse wave velocity (PWV) and left ventricular mass index (LVMI), left ventricular (LV), right ventricular (RV), and left atrial (LA) myocardial strain and respective ejection fractions (EF) assessed by cardiac …


A Remarkable Diversity Of Syngnathid Fishes In A Highly Modified Large Coastal Embayment In The Southeastern Indian Ocean, Glenn I. Moore, Jenelle A. Ritchie, Georgia M. Nester, Glenn A. Hyndes, Alan J. Kendrick Jul 2026

A Remarkable Diversity Of Syngnathid Fishes In A Highly Modified Large Coastal Embayment In The Southeastern Indian Ocean, Glenn I. Moore, Jenelle A. Ritchie, Georgia M. Nester, Glenn A. Hyndes, Alan J. Kendrick

Research outputs 2022 to 2026

Southern Australia supports a high diversity of fishes in the family Syngnathidae, which is recognised as globally threatened, facing threats from coastal development, over-exploitation and bycatch. In southwestern Australia, Cockburn Sound houses a large industrial port and naval defence assets with plans to substantially expand the port facilities but also sits within a recognised syngnathid ‘hotspot’. Using a broad array of data sources, including historical museum vouchers, published records, historical and contemporary observations from notebooks and diving surveys, historical and contemporary trawl surveys, citizen science observations and environmental DNA, we compiled 4839 records of syngnathid fishes from the embayment. Twenty-one …


Co-Design And Pilot Testing Of A Nurse-Led Gp-Supported Self-Management Intervention For Breast Cancer Survivors With Cardiovascular Diseases: A Study Protocol, Anu Correya, Jing Yu Tan, Xian Liang Liu, Daniel Bressington, Leah East, Tao Wang Jul 2026

Co-Design And Pilot Testing Of A Nurse-Led Gp-Supported Self-Management Intervention For Breast Cancer Survivors With Cardiovascular Diseases: A Study Protocol, Anu Correya, Jing Yu Tan, Xian Liang Liu, Daniel Bressington, Leah East, Tao Wang

Research outputs 2022 to 2026

Background/Objectives: Self-management intervention strategies are recommended to address the needs of breast cancer survivors (BCSs) who have cardiovascular diseases (CVDs). Despite the benefits, these strategies are often suboptimally implemented, resulting in inadequate cardiovascular management among BCS with CVDs. The project aims to develop a nurse-led and GP-supported self-management (NGPS) intervention to reduce cardiovascular risks in BCS with CVDs and evaluate its feasibility and potential effects in primary care settings using the double diamond co-design process and the Medical Research Council (MRC) Framework for Developing and Evaluating Complex Interventions.

Methods: The study will be conducted in two phases. In phase I, …