Digital Commons Network^™

Breaking Down Seagrass Fragmentation In A Marine Heatwave Impacted World Heritage Area, Michael D. Taylor, Simone Strydom, Matthew W. Fraser, Ana M.M. Sequeira, Gary A. Kendrick

Research outputs 2022 to 2026

Marine heatwaves, and other extreme climatic events, are driving mass mortality of habitat-forming species and substantial ecological change worldwide. However, habitat fragmentation is rarely considered despite its role in structuring seascapes and potential to exacerbate the negative impacts of habitat loss. Here, we quantify fragmentation of globally significant seagrass meadows within the Shark Bay World Heritage Area before and after an unprecedented marine heatwave impacting the Western Australian coastline over the austral summer of 2010/11. We use a spatial pattern index to quantify seagrass fragmentation from satellite-derived habitat maps (2002, 2010, 2014 and 2016), assess potential predictors of fragmentation and …

Driven To Serve: Exploring Meaningful Work For Doctors Through The Lens Of Public Service Motivation, Abid Hussain, Uma Jogulu, Esme Franken, Rahatulaain Ahmad, Tim Bentley

Research outputs 2022 to 2026

This paper reports on a study of meaningful work amongst doctors in a non-Western context. This study advances the current understanding of meaningful work by establishing a connection with public service motivation theory. By examining unique contextual features where societal, public systems, institutional, and individual factors are diverse and unique, we contribute to public service motivation theory in three ways. First, public service motivation theory argues that individuals are not only driven by self-interest but also by a drive to contribute to society and to help others, and that this motivation is particularly high amongst public servants in the West. …

I Am Still Concerned About Them: Grandmother Kinship Caregivers And The Challenge Of Abuse By Children In Their Care, Hajara Bentum, Vicki Banham, Kwadwo Adusei-Asante

Research outputs 2022 to 2026

Research evidence has shown that adverse occurrences within the kinship caregiving environment, such as the grandparents' experiences of violence and abuse, may introduce new stressors or exacerbate existing aged-related challenges, leading to adverse impacts on grandparent kinship carers. Yet no research has explored the impact of abuse and violence experienced by grandparent kinship caregivers from children in their care. This study involved narrative interviews with 31 grandmother kinship caregivers in Ghana to explore the adverse effects of the abuse they have experienced from children in their care. The study findings revealed the following impacts on grandmothers: (1) high blood pressure, …

Blending Minds, Balancing Goals: Tmt Heterogeneity And Sustainable-Innovation In Family Firms, Mahdi Vesal, Muhammad Aftab Alam, Mohammad H. Rahmati

Research outputs 2022 to 2026

Family firms often prioritize profitability and growth, but balancing these with environmental sustainability is challenging. While TMT heterogeneity shapes various performance outcomes, its role in addressing the profitability–environmental sustainability dilemma in family firms remains unclear. Building on the upper echelons theory, we investigate how TMT heterogeneity drives the simultaneous pursuit of financial and environmental performance, which we refer to as hybrid financial–environmental performance, through sustainable-innovation practices. Additionally, we examine how family-firm governance mechanisms influence these relationships. Analyzing data from two matched samples of CEOs and senior production managers of Australian family firms, we find not only that TMT heterogeneity enhances …

It Makes Me Feel Dysphoric: Transgender And Non-Binary Students’ Perspectives Of Gendered Grouping Practices And Curriculum Provision In Secondary School Physical Education In England, Shaun D. Wilkinson, Dawn Penney

Research outputs 2022 to 2026

This study foregrounds the voices of transgender (trans) and non-binary students in a large-scale mixed-methods investigation of gendered grouping practices and curriculum provision in secondary school physical education (PE) in England. Theoretically, the research brought together an interdisciplinary framework for educational inclusion and the trans inclusion staged model to pursue conceptualisations and expressions of inclusion that disrupt cisnormative policies and structures. A survey of 14 co-educational secondary schools generated data from 36 students who identified as trans (n = 18) or non-binary (n = 18). The findings revealed that most trans (n = 16) and all non-binary students expressed preferences …

The Nurse's Role In Curative-To-Palliative Transitions In Advanced Cancer: A Theory Synthesis Using Turner's Method, Geya George, Deborah Kirk, Davina Porock

Research outputs 2022 to 2026

Aim: This paper aims to explain the process of formulating a robust theory that comprehensively explains the nurse's role during the transition from curative to the palliative phase in advanced cancer care. Design: A qualitative theory synthesis approach was applied, utilising Turner's 9-step theory synthesis method to integrate five grounded theories and 10 qualitative studies. The Walker and Avant method of concept development and analysis further ensured rigour. Methods: Turner's theory synthesis was used to formulate a more comprehensive, testable theory from five existing grounded theories and 10 other qualitative studies that explain the nurse's role in supporting and facilitating …

A Comprehensive Review Of Cyber Security And Current Practices In Global Mining Critical Infrastructure, Abu Barkat Ullah, Wanli Ma, Mohiuddin Ahmed, Bazlur Rashid, Munir Ahmad Saeed, Omer Arshad, Utkarsh Raghav

Research outputs 2022 to 2026

The purpose of the study is to explore the reasons behind the low uptake of Information Security Management Standards (ISMS), Asset Management, and Business Continuity Plans despite increasing cyber threats to the mining sector. Mining companies need to modernize and automate to keep up with the ‘Fourth Industrial Revolution’, driven by disruptive technology, forcing systems and technologies to become more integrated, increasing cyber attack threats. To address this, we conducted a literature review analyzing the mining industry across various regions. The research is based on a qualitative analysis of diversified literature. The results highlighted factors behind the low uptake of …

The Paradoxical Effects Of Emerging Mining Technologies On Psychosocial Work Factors: An Integrated Framework And Research Agenda, Keyao Li, Mengting (Rachel) Xia, Tim Bentley

Research outputs 2022 to 2026

As industries strive for healthier, safer, and more productive workplaces, a comprehensive understanding of psychosocial work factors is essential for sustainable improvement. In the context of digital transformation, automation and emerging technologies have led to mixed health and safety outcomes. However, how emerging technologies are reshaping work and organisational structures and driving varied effects, remains unclear. This uncertainty provides little guidance for practitioners and researchers on systematically integrating new technologies to optimise health and safety. This paper argues that a deeper understanding of how the evolving technological landscape affects psychosocial work factors is essential for bridging this research gap. Focusing …

Extending The Theory Of Planned Behaviour To Explain Contract Cheating In The Age Of Generative Ai: Evidence From Australian Higher Education, Madugoda Gunaratnege Senali

Research outputs 2022 to 2026

Academic contract cheating (CC) poses a significant challenge for Higher Education (HE), a problem that has become more complex with the increasing use of Generative Artificial Intelligence (Gen AI) tools. While similarity detection software can flag AI-generated text, it remains ineffective in identifying CC, potentially displacing misconduct rather than reducing it. Drawing on and extending the Theory of Planned Behaviour (TPB), this study examines how traditional TPB constructs and technology-mediated perceptual factors jointly influence students’ intentions and behaviours related to CC within the Australian HE context. The findings reveal significant direct and indirect pathways linking perceived instructor involvement, detection awareness, …

Mental Health Professionals’ Perspectives On Essential Elements Of Telehealth Family Psychoeducation For Major Depressive Disorder: An Exploratory Study, Obumneke Obieche, Jing Yu Tan, Sita Sharma, Daniel Bressington, Tao Wang

Research outputs 2022 to 2026

Family-inclusive interventions, such as family psychoeducation (FPE), improve outcomes in major depressive disorder (MDD), particularly when tailored to the needs of individuals with MDD, their families, and carers. This study explored mental health professionals’ (MHPs) perspectives on the essential elements of telehealth FPE for MDD, including patients’ and their families’ informational and support needs. An exploratory cross-sectional study was conducted as part of the Supportive Program for Advancing Recovery, Knowledge, and Empowerment in Depression (SPARKED) research project, using an online questionnaire targeting MHPs within a regional area of Australia. Data analysis included descriptive statistics and quantitative and qualitative content analysis, …

Quantifying The Fatal And Non-Fatal Burden Of Disease Associated With Child Growth Failure, 2000–2023: A Systematic Analysis From The Global Burden Of Disease Study 2023, Gbd 2023 Child Growth Failure Collaborators, Amanuel Gebremedhin

Research outputs 2022 to 2026

Background: Child growth failure (CGF), which includes underweight, wasting, and stunting, is among the factors most strongly associated with mortality and morbidity in children younger than 5 years worldwide. Poor height and bodyweight gain arise from a variety of biological and sociodemographic factors and are associated with increased vulnerability to infectious diseases. We used data from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2023 to estimate CGF prevalence, the risk of infectious diseases associated with CGF, and the disease mortality, morbidity, and overall burden associated with CGF.

Methods: In this analysis we estimated the all-cause and …

Boodja First, Country First: Kaarl Ngaariny, Right Fire, Sandra Wooltorton, Len Collard, Oral Mcguire

Research outputs 2022 to 2026

How might belonging to Country guide us toward reciprocity, care and renewal in a time of breached planetary boundaries? Drawing on Noongar knowledge and the environmental humanities, this research paper explores how homes, gardens, farms, energy systems and investments are already entangled within Country, inviting a shift from separation to nurture. We propose that ideas around ownership, social mobility, comfort and growth shape suburban identities (including our own) and inhibit regenerative change. Within high-carbon economies such as Australia, ecological limits are often experienced as external constraints on human flourishing. When people recognise themselves as part of Country, however, limits can …

Common Census Methods Can Lead To Fundamentally Different Ecological Interpretations Of Coral Reef Fish Communities, Helen F. Yan, Samantha K. Crisp, David R. Bellwood, Alexandre C. Siqueira, Sterling B. Tebbett

Research outputs 2022 to 2026

In an era of large-scale stressors, scientists are racing to collate equally large datasets to answer macroecological questions. Coral reefs lie at the forefront of system-wide transformations and are thus the focus of many macroecological studies. A lack of standardised, global data across time, however, has resulted in the coalition of data from disparate sources, often comprising different survey methods. However, can we make the same ecological inferences from data collected using different survey protocols? Here, we employed two of the most common reef fish census techniques—point counts and belt transects—of varying survey effort (time and area) to assess whether …

Circulating Metabolite Signatures Associated With Amyloid Positivity, Cognitive Performance And Plasma P-Tau181 Levels In Cognitively Unimpaired Older Adults, Tahmida Sharmin, James D. Doecke, Pratishtha Chatterjee, Hamid R. Sohrabi, Henrik Zetterberg, Nicholas J. Ashton, Manohar L. Garg, Kaj Blennow, Ralph N. Martins

Research outputs 2022 to 2026

Emerging evidence suggests altered circulating metabolite levels in individuals with Alzheimer’s disease (AD) and/or mild cognitive impairment (MCI) compared to healthy controls; how these metabolites alter with early cortical amyloidosis—before symptom onset—remains unclear. This cross-sectional study aimed to investigate plasma metabolites obtained through targeted profiling using the Biocrates AbsoluteIDQ® p400 HR kit. The study cohort comprises 100 cognitively unimpaired (CU) older adults, stratified into CU Aβ− (negative positron emission tomography [PET]-amyloid-beta [Aβ]) and CU Aβ+ (positive PET-Aβ) groups. Significantly altered metabolites were further analysed for associations across amyloid plaque deposition, cognitive performance and plasma tau phosphorylated at threonine 181 (P-tau181) …

Exploring Factors That Influence Meal Management And Eating Behaviours In People Living With Huntington’S Disease, Joanna Rees, Ran Yan, Melanie Clark, Melanie Jolly, Alex Fisher, Amanda Devine, Simon M. Laws, Kelly Moes, Travis Cruickshank

Research outputs 2022 to 2026

Purpose: People living with Huntington’s disease (pwHD) experience cognitive and motor changes that affect meal planning, preparation and food consumption. This study explored factors that influence meal management and eating behaviours of pwHD and their families.

Methods: This is a qualitative study employing semi-structured interviews and thematic analysis. Participants included gene-positive individuals living in Perth Western Australia, ranging from asymptomatic or experiencing subtle changes, to early to mid-stage HD.

Results: Nine individuals (mean age 47 ± 12.3 years) were interviewed for the study, including five gene-positive being asymptomatic or minimal symptoms. Seven themes were identified reflecting participants’ existing meal management …

How Perceived Empowerment And Place Attachment Drive Residents’ Support For Sustainable Tourism In Central Vietnam: A Serial Mediation Model, Phuong Kim Thi Tran, Nhi Thao Ho-Mai, Tuan Nien Tran, Vinh Trung Tran

Research outputs 2022 to 2026

From the Theory of Planned Behavior (TPB) and the Stimulus-Organism-Response (S–O–R) framework, this study proposes a serial mediation model to examine psychological drivers of residents’ support for sustainable tourism development (STD) in central Vietnam. Specifically, this study investigates how perceived empowerment and place attachment as stimulus influence residents’ attitudes (ATT), subjective norms (SN), and perceived behavioral control (PBC) as organism, which in turn shape their intentions to support STD as response. The study empirically surveyed 686 residents engaging with tourism services in three cities, namely Hue, Da Nang, and Quang Nam, in central Vietnam. This study utilised both online and …

Leveraging Hr Analytics Capability For Sustainable Supply Chains: The Roles Of Green Hrm, Ai-Driven Capabilities And Resource Commitment, Philip Opoku Mensah, Emmanuel Mensah Kparl, Abdul Razak Suleman, Michael Kyei-Frimpong, Adam Abdul Mumin, Elias Appiah-Kubi, Charlotte Adjanor-Doku

Research outputs 2022 to 2026

Among many firms in emerging economies, investments in HR analytics promise strategic insight yet often fail to translate into measurable sustainability gains. This study theorises and tests how HR analytics capability drives supply chain sustainability through the strategic enactment of Green HRM (GHRM). Drawing on dynamic capability theory and socio-technical systems theory, we propose that HR analytics capability indirectly enhances supply chain sustainability by enabling firms to design and implement data-informed GHRM strategies that align workforce practices with environmental objectives. We further argue that this indirect effect is contingent on two distinct enabling conditions: AI-driven capability, which strengthens the translation …

Participatory Work Design Intervention In A Disability Support Organization: Effects On Job Demands, Social Support, And Burnout, Arian Kunzelmann, Connie Deng, Lucinda Iles, Ryan Cheng, Helena Nguyen, Anya Johnson, Sharon K. Parker

Research outputs 2022 to 2026

This study evaluates the effectiveness of a participatory work design intervention to improve job quality and mental well-being in a disability support organization. We investigate whether the intervention is associated with changes in burnout (i.e. disengagement, work-related, client-related), and we assess the changes in work design through which the intervention has its effects. We hypothesized that the effects of the work design intervention on burnout occur via changes in social support (i.e. co-worker instrumental and emotional support) and job demands (i.e. role conflict, time pressure). 72 participants were involved (N = 21 in the intervention group, 66.7% female; N = …

Playworld Translanguaging: A Place-Based Approach For Translanguaging Play Pedagogy In Early Childhood, Christine Robinson, Carly Steele, Toni Dobinson, Grace Oakley, Samina Manado, Katie Grace, Graeme Gower

Research outputs 2022 to 2026

Conceptualised from a vision to honour children’s languages, agency and cultural ways of knowing, this research presents findings from a place-based translanguaging play pedagogy for early childhood called Playworld Translanguaging. In the remote Kimberley of Western Australia, researchers collaborated with educators in a Kindergarten/Primary/Yr 1 class of mostly Aboriginal children who have Bardi Jawi as their ancestral language, co-designing ways to revitalise this language through play pedagogy in ways intimately connected to place. Our Playworld Translanguaging approach reimagined Conceptual PlayWorlds (Fleer, 2018) with the intention of integrating pedagogical translanguaging. Following Indigenist research principles, critical participatory action research (CPAR) was the …

Serum Igg N-Glycosylation Profiles Distinguish Primary Sjögren’S Disease, Rheumatoid Arthritis, And Systemic Lupus Erythematosus And Are Associated With Disease Activity In Sjögren’S Disease, Zhixian Chen, Xiaojia Xu, Manshu Song, Fengcai Shen, Haifeng Hou, Wei Wang, Ling Lin

Research outputs 2022 to 2026

Background: IgG N-glycosylation regulates immune effector functions and inflammation, but disease-specific patterns in primary Sjögren’s disease (SjD), rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) are insufficiently defined, particularly in SjD.

Objectives: To identify serum IgG N-glycan biomarkers that differentiate SjD, RA, and SLE and reflect disease activity in SjD.

Design: A clinical case-control study.

Methods: Serum IgG N-glycans from 88 SjD patients, 102 RA patients, 86 SLE patients and 91 healthy controls were profiled using ultra-performance liquid chromatography. Discriminative glycans were selected through machine learning-based feature selection and evaluated for their diagnostic performance using cross-validated logistic regression and receiver …

Targeting Of The Oncogenic Fusion Ewsr1-Fli1 In Ewing Sarcoma By Crispr/Dcas9 Silencers, Shahama Taifour, Chee Wai Wong, Christopher Wallis, Edina Wang, Ash W.J. Tie, Eleanor Woodward, Charlene Waryah, Mahnaz Hosseinpour, Dilys Lam, Ryan Lister, Larissa Dymond, Andrew Woo, Peter J. Houghton, K. Swaminathan Iyer, Marck Norret, Cameron W. Evans, Louise Winteringham, Silvana Gaudieri, Pilar Blancafort

Research outputs 2022 to 2026

Despite the revolutionary impact of genome engineering tools in medicine, the safe and effective intracellular delivery of CRISPR remains a major obstacle to clinical applications. Here, we utilize precision molecular targeting and delivery strategies based on CRISPR-nuclease-dead Cas9 (dCas9) systems adapted for epigenetic repression (dCas9-Krüppel-associated box [KRAB]) to silence oncogenic drivers with high selectivity. As proof of principle, we target the EWSR1-FLI1 translocation, which encodes a chimeric and hard-to-drug oncogenic transcription factor driving approximately 85% of the cases of Ewing sarcoma (EWS)—an aggressive childhood malignancy. We describe the development of a programmable, non-viral polymeric system for the delivery of dCas9-KRAB …

The Gender Gap In Writing: Gender Profiles For Paper- And Computer-Based Writing In Early Education, Anabela Malpique, Deborah Pino-Pasternak, Mustafa Asil

Research outputs 2022 to 2026

Research Findings: The gender gap in writing has received strong interest from literacy education and research, based on recurrent reports of gender differences in writing typically favoring female students. In this study, we investigated gender differences on paper- and computer-based text composing performance among early primary children (N = 544 Grade 2 students). Multilevel analyses revealed significant differences between boys and girls in both compositional quality and productivity across writing modalities. Specifically, boys consistently exhibited lower scores in both compositional quality and productivity compared to girls. Gender differences were notably influenced by various student-level factors such as handwriting automaticity, spelling …

Wuthuga (Dugong) Population Status In Gathaagudu (Shark Bay) Sea Country, Holly Raudino, Amanda Hodgson, Chris Cleguer, Kym Reeve, Molly Moustaka, Osmar Luiz, Simone Strydom, Kathy Murray, Neilisha Oakley, Tariq Mcdonald, Abby Leyendekkers, Jay Hayes, Marlee Hutton, Julian A. Tyne, Kelly Waples

Research outputs 2022 to 2026

Introduction: Monitoring trends in wildlife populations and their response to pressures is integral but challenging for conservation managers. Wuthuga (dugongs (Dugong dugon)) are increasingly vulnerable as extreme climatic events, such as marine heatwaves and flooding, intensify with a warming climate and increasingly impact the seagrass they are dependent upon.

Methods: This study estimated wuthuga abundance using two methodologies: conventional observer aerial surveys, as part of a time-series of surveys, alongside aerial imagery, in Gathaagudu (Shark Bay), Western Australia in 2023. We compare the contemporary abundance estimates with long term monitoring data (1989 – 2018) to identify temporal trends in abundance …

Association Of Rurality Status With All-Cause And Cancer-Specific Survival: A Systematic Review And Meta-Analysis Adjusting For Clinical Factors, Demographics, And Geographical Remoteness, Skye Marshall, Charlene Wright, Lucy Leigh, Sharina Riva, Megan Crichton, Helena Rodi, Hannah Jongebloed, Elizabeth A. Johnston, Rebecca J. Bergin, Anna Chapman, Fiona Crawford-Williams, Nicolas H. Hart, Laura Alston, Joel Rhee, Lan Gao, Kate Gunn, Anna Ugalde

Research outputs 2022 to 2026

The association of rurality status with cancer survival has not been consistently reported. In people diagnosed with cancer, this review aims to determine the association of rural and remote living with survival as compared to urban living, and to determine the modifying effects of geographical, medical, demographic, and socioeconomic factors on cancer survival. A systematic review with meta-analysis and meta-regression was conducted, searching four databases in August 2024. Observational cohort studies were eligible if they reported all-cause or cancer-specific survival according to rurality status in Organisation for Economic Co-operation and Development (OECD) countries. All ages, sexes, and cancer types were …

Bridging Idealism And Reality: Nursing Students’ Perceptions About The Impact On Their Wellbeing From Being A Nurse: A Qualitative Study, Louise M. Allen, Karen Missen, Simon J, Cooper

Research outputs 2022 to 2026

Background: Nursing students often enter undergraduate nursing programs with idealistic perceptions of how nursing can impact personal wellbeing. The gap between expectations and clinical realities may hinder progress and contribute to attrition. Aim: To explore nursing students' perceptions of how the nursing profession impacts a nurse's wellbeing. Methods: This descriptive qualitative study, informed by Transformational Learning Theory, involved semi-structured online interviews with 23 nursing students from three Australian universities. Interviews were transcribed verbatim and thematically analysed. Results: Students began the program with idealistic views about the physical, emotional and social impacts of nursing. Clinical placements played a key role in …

Influence Of Chronotype On Cycling Performance In Simulated 20-Km Time Trials—A Pilot Study, Sabrina Forster, Sascha Schwindling, Chris Abbiss, Fabienne Döringer, Andreas Klütsch, Anne Hecksteden, Tim Meyer

Research outputs 2022 to 2026

The chronotype (CT) refers to an individual's diurnal preference towards morningness (M) or eveningness (E). The aim of this study was to determine the influence of chronotype on 20-km cycling performance throughout the day. Seventy-six competitive male cyclists and triathletes completed the Morningness-Eveningness Questionnaire to determine chronotype. Only participants categorised as ‘definite’ M- (n = 10) and E-types (n = 7) were included in the study. In a randomised order and separated by 2–7 days, participants performed four self-paced 20-km cycling time trials at four different times of the day (06:00 h, 12:00 h, 18:00 h, 22:00 h). Mental readiness …

Parents’ Utilisation Of The Literacy-Based Text Message Program Kindytxt, Amanda Binns

Research outputs 2022 to 2026

Text messaging programs have emerged as effective tools for enhancing parental engagement in children’s home-based literacy development, as substantiated by a growing body of research. This paper presents findings from a doctoral study that examined parental experiences and perceptions of a literacy-based text messaging program, with particular emphasis on how such initiatives inform and shape literacy practices in families with kindergarten-aged children. Rooted in the frameworks of social constructivism and interpretivism, the research privileges participants’ unique perspectives to explore the varied meanings parents construct around their use of the Kindytxt program. The study was theoretically informed by Vygotsky’s sociocultural theory, …

Performance Investigation Of Microchannel Heat Sink With Biomimetic Trefoil Cavities On Different Walls, Sadiq Ali, Numan Habib, Faraz Ahmad, Aamer Sharif, Ana Vafadar

Research outputs 2022 to 2026

The modern world is shifting towards digitalization and miniaturization, leading to higher flux densities in electronic components and machines. However, conventional cooling methods, such as air-cooled smooth channels, are proving inadequate for removing the huge amounts of heat generated, thereby compromising the reliability and operational lifespan of electronic systems. This necessitates urgently exploring and analyzing modern techniques like microchannel cooling to improve its efficiency. This work uses ANSYS to conduct numerical simulations and investigates the heat transfer and flow behavior in a microchannel heat sink. The smooth channel is used to investigate and validate the flow behavior with the available …

Plasma Aβ42/40 Predicts Progression From Aβ-Amyloid Negative To Positive Pet Scans, Azadeh Feizpour, Vincent Doré, Pierrick Bourgeat, James D. Doecke, Rodrigo Canovas, Simon M. Laws, Tenielle Porter, Kun Huang, Christopher Fowler, Ralph N. Martins, Paul Maruff, Hamid R. Sohrabi, Michael W. Weiner, John C. Morris, Tammie L.S. Benzinger, Suzanne E. Schindler, Randall J. Bateman, Yan Li, Ovod Vitaliy, Larry Ward, Jurgen Mejan-Fripp, Colin L. Masters, Victor L. Villemagne, Christopher C. Rowe

Research outputs 2022 to 2026

Background The agreement between plasma Aβ42/40 and Aβ positron emission tomography (PET) is approximately 75 %, with ∼85 % of discrepancies due to positive plasma but negative PET results. It is unclear whether this reflects Aβ changes in plasma before PET-detectable. Objectives To assess the influence of Aβ42/40 positivity on risk of progression to Aβ PET positivity, and feasibility of using plasma Aβ42/40 tests to enrich a primary prevention trial. Design A prospective longitudinal cohort study. Setting Participants of Australian Imaging, Biomarkers and Lifestyle study (AIBL), Alzheimer’s Disease Neuroimaging Initiative (ADNI), and Open Access Series of Imaging Studies 3 (OASIS3). …

The Gut Microbiome Mediates The Association Between A Flavonoid-Rich Diet And Masld In A Population-Level Analysis, William Bell, Amy Jennings, Nicola P. Bondonno, Andre Franke, Corinna Bang, Marcus Both, Jan Kassubek, Hans Peter Müller, Jan Borggrefe, Wolfgang Lieb, Tilman Kühn, Aedín Cassidy

Research outputs 2022 to 2026

Purpose: A growing body of evidence suggests diets rich in flavonoids may protect against metabolic-dysfunction associated steatotic liver disease (MASLD) development and progression. As the gut microbiome is important in the biotransformation of flavonoids to their constituent bioactive metabolites, studies on the potential mediating role of the gut microbiome in the association between dietary flavonoid intakes and MASLD are warranted but lacking. Thus, this study aims to examine the associations between a diet rich in flavonoids and MASLD, and assess the potential mediating role of the gut microbiome. Methods: In a cross-sectional analysis (n = 531), using the FlavoDiet score …