Digital Commons Network^™

Cultural Transmission Modes Of Music Sampling Traditions Remain Stable Despite Delocalization In The Digital Age, Mason Youngblood

Publications and Research

Music sampling is a common practice among hip-hop and electronic producers that has played a critical role in the development of particular subgenres. Artists preferentially sample drum breaks, and previous studies have suggested that these may be culturally transmitted. With the advent of digital sampling technologies and social media the modes of cultural transmission may have shifted, and music communities may have become decoupled from geography. The aim of the current study was to determine whether drum breaks are culturally transmitted through musical collaboration networks, and to identify the factors driving the evolution of these networks. Using network-based diffusion analysis …

Cognitive, Behavioral, And Situational Influences On Relapse To Smoking After Group Treatment For Tobacco Dependence, Sara E. Lunden, Jami C. Pittman, Neelam Prashad, Ria Malhotra, Christine Sheffer

Publications and Research

Socioeconomic disparities in treatment failure rates for evidence-based tobacco dependence treatment are well-established. Adapted cognitive behavioral treatments are extensively tailored to meet the needs of lower socioeconomic status (SES) smokers and dramatically improve early treatment success, but there is little understanding of why treatment failure occurs after a longer period of abstinence than with standard treatment, why early treatment success is not sustained, and why long-term treatment failure rates are no different from standard treatments. We sought to understand the causes of treatment failure from the perspective of diverse participants who relapsed after receiving standard or adapted treatment in a …

Effects Of Am80 Compared To Ac261066 In A High Fat Diet Mouse Model Of Liver Disease, Marta Melis, Xiao-Han Tang, Steven E. Trasino, Viral M. Patel, Daniel J. Stummer, Jose Jessurun, Lorraine J. Gudas

Publications and Research

The roles of retinoids in nonalcoholic fatty liver disease (NAFLD) remain unclear and a better understanding may lead to therapies that prevent or limit NAFLD progression. We examined the actions of retinoic acid receptor (RAR) agonists- AM80 for RARαand AC261066 for RARβ2- in a murine model of NAFLD. We fed wild type C57Bl/6 mice a chow or a 45% high fat diet (HFD) for 12 weeks, followed by 4 additional weeks with the HFD+AM80; HFD +AC261066; or HFD. The HFD+AM80 group showed greater hyperglycemia and glucose intolerance compared to other groups. Histopathological evaluation of the livers showed the highest degree …

Putative Cellular And Molecular Roles Of Zika Virus In Fetal And Pediatric Neuropathologies, Rajendra Ghardbaran, Rajendra Ghardbaran, Latchman Somenarain

Publications and Research

Although the World Health Organization declared an end to the recent Zika virus (ZIKV) outbreak and its association with adverse fetal and pediatric outcome, on November 18, 2016, the virus still remains a severe public health threat. Laboratory experiments thus far supported the suspicions that ZIKV is a teratogenic agent. Evidence indicated that ZIKV infection cripples the host cells' innate immune responses, allowing productive replication and potential dissemination of the virus. In addition, studies suggest potential transplacental passage of the virus and subsequent selective targeting of neural progenitor cells (NPCs). Depletion of NPCs by ZIKV is associated with restricted brain …

Biotransformed Metabolites Of The Hop Prenylflavanone Isoxanthohumol, Hyun Jung Kim, Soon-Ho Yim, Fubo Han, Bok Yun Kang, Hyun Jin Choi, Da-Woon Jung, Darren R. Williams, Kirk R. Gustafson, Edward J. Kennelly, Ik-Soo Lee

Publications and Research

A metabolic conversion study on microbes is known as one of the most useful tools to predict the xenobiotic metabolism of organic compounds in mammalian systems. The microbial biotransformation of isoxanthohumol (1), a major hop prenylflavanone in beer, has resulted in the production of three diastereomeric pairs of oxygenated metabolites (2–7). The microbial metabolites of 1 were formed by epoxidation or hydroxylation of the prenyl group, and HPLC, NMR, and CD analyses revealed that all of the products were diastereomeric pairs composed of (2S)- and (2R)- isomers. The structures of these metabolic compounds were elucidated to be (2S,200S)- and (2R,200S)-40 …

Microrna-4719 And Microrna-6756-5p Correlate With Castration-Resistant Prostate Cancer Progression Through Interleukin-24 Regulation, Dibash K. Das, Leah Persaud, Moira Sauane

Publications and Research

Prostate cancer (PCa) is the second leading cause of cancer death in the United States. The five-year survival rate for men diagnosed with localized PCa is nearly 100%, yet for those diagnosed with aggressive PCa, it is less than 30%. The pleiotropic cytokine Interleukin-24 (IL-24) has been shown to specifically kill PCa cells compared to normal cells when overexpressed in both in vitro and in vivo studies. Despite this, the mechanisms regulating IL-24 in PCa are not well understood. Since specific microRNAs (miRNAs) are dysregulated in PCa, we used miRNA target prediction algorithm tools to identify miR-4719 and miR-6556-5p as …

Standards For Distribution Models In Biodiversity Assessments, Miguel B. Araújo, Robert P. Anderson, A. Márcia Barbosa, Colin M. Beale, Carsten F. Dormann, Regan Early, Raquel A. Garcia, Antoine Guisan, Luigi Maiorano, Babak Naimi, Robert B. O'Hara, Niklaus E. Zimmermann, Carsten Rahbek

Publications and Research

Demand for models in biodiversity assessments is rising, but which models are adequate for the task? We propose a set of best-practice standards and detailed guidelines enabling scoring of studies based on species distribution models for use in biodiversity assessments. We reviewed and scored 400 modeling studies over the past 20 years using the proposed standards and guidelines. We detected low model adequacy overall, but with a marked tendency of improvement over time in model building and, to a lesser degree, in biological data and model evaluation. We argue that implementation of agreed-upon standards for models in biodiversity assessments would …

Deletion Of Mgr2p Affects The Gating Behavior Of The Tim23 Complex, Oygul Mirzalieva, Shinhye Jeon, Kevin Damri, Ruth Hartke, Layla Drwesh, Keren Demishtein-Zohary, Abdussalam Azem, Cory D. Dunn, Pablo M. Peixoto

Publications and Research

The TIM23 complex is a hub for translocation of preproteins into or across the mitochondrial inner membrane. This dual sorting mechanism is currently being investigated, and in yeast appears to be regulated by a recently discovered subunit, the Mgr2 protein. Deletion of Mgr2p has been found to delay protein translocation into the matrix and accumulation in the inner membrane. This result and other findings suggested that Mgr2p controls the lateral release of inner membrane proteins harboring a stop-transfer signal that follows an N-terminal amino acid signal. However, the mechanism of lateral release is unknown. Here, we used patch clamp electrophysiology …

Idiot Science For A Blue Humanities: Shakespeare's The Comedy Of Errors And Deleuze's Mad Cogito, Steven Swarbrick

Publications and Research

Can we imagine a Blue Humanities that takes the non-relation as a starting point for ecological thought? I believe we can. Following Shakespeare and Deleuze, this essay engages in a thought experiment that, if it is not too absurd, might, like the ship of fools of medieval times, unmoor the Blue Humanities from its current safe harbor by putting the thought of ‘our’ world under erasure. This is not a matter of turning thought around, such that, by turning to the sea, we turn thought away from calculation and instrumental reason and rediscover our true nature. Rather, the image of …

Addressing The Technical Challenges Of Open Educational Resources, Steven Ovadia

Publications and Research

As open educational resources (OER) becomes a more established concept, its growth and continued success not only center around the creation of new content but also depend upon the development and evolution of existing content, licenses permitting. The evolution of and persistent access to existing content requires easily editable works and the ability to download local copies of OER files so that no technical limitations hinder what the license permits. Such measures as text files, OpenDocument formats, and version control present a way to keep OER content editable and shareable, in compliance with licenses. Librarians are uniquely positioned to help …

A Case Study Comparing Student Experiences And Success In An Undergraduate Mathematics Course Offered Through Online, Blended, And Face-To-Face Instruction, Virginia L. Thompson, Yonghong L. Mcdowell

Publications and Research

A research study was conducted at an undergraduate college, comparing student experiences and successes in a mathematics course offered fully online, blended and face-to-face. In online courses, students enjoy the flexibility of learning at their own pace, not having to travel to school, as well as having consistent access to courses through a web browser. However, such conveniences do not automatically produce positive results. Some students lack the discipline, enthusiasm and sometimes feel socially isolated from their peers when learning online. Despite these challenges, online courses continue to be developed in response to the demand for online learning opportunities. However, …

Social Learning Through Associative Processes: A Computational Theory, Johan Lind, Stefano Ghirlanda, Magnus Enquist

Publications and Research

Social transmission of information is a key phenomenon in the evolution of behaviour and in the establishment of traditions and culture. The diversity of social learning phenomena has engendered a diverse terminology and numerous ideas about underlying learning mechanisms, at the same time that some researchers have called for a unitary analysis of social learning in terms of associative processes. Leveraging previous attempts and a recent computational formulation of associative learning, we analyse the following learning scenarios in some generality: learning responses to social stimuli, including learning to imitate; learning responses to non-social stimuli; learning sequences of actions; learning to …

All For One Or Each For Her Own: Do Polygamous Families Share And Share Alike?, Kristin Mammen

Publications and Research

This paper examines whether the mother’s rank (whether she is a senior or junior wife) in polygamous households in Côte d’Ivoire injects favoritism that could lead to differential investment in children. The concern is that favoritism based on mother’s rank could cause an inefficient allocation of household resources. This question is analyzed employing Ordinary Least Squares on a Living Standards Measurement Survey microdataset collected by the World Bank. An interesting pattern is found: whether the senior or junior children are advantaged depends on the age difference between the senior and junior wife. Senior children are at an advantage when the …

"Do They Know The Normal Language?": Language Attitudes And Ideologies In German Hip Hop Culture, Matt Garley

Publications and Research

This article presents a theoretical discussion of the relationship between language ideologies and language attitudes and builds on previous work by providing an organized framework connecting these notions. This framework is evaluated with reference to online and offline ethnographic work surrounding attitudes and ideologies about anglicisms, or English loanwords, among German hip hop fans and artists. Language attitudes are theorized as individual thoughts and expressions about language, and are often, but not always, informed by individual reproductions of language ideologies, which are conceived of as systematic, shared over groups of individuals, enduring, and mediated. Language ideologies can then be organized …

Tar Wars: Oil, Environment And Alberta's Image, By Geo Takach, Gordon Alley-Young

Publications and Research

No abstract provided.

Large Pelvic Tubercle In Orangutans Relates To The Adductor Longus Muscle, Brian M. Shearer, Magdalena Muchlinski, Ashley S. Hammond

Publications and Research

Orangutan pelves commonly exhibit a large, projecting tubercle in the iliopubic region, historically assumed to homologous to the pubic tubercle in humans. However, it is not clear whether this tubercle is a unique feature of Pongo, or if it is anatomically homologous with the human pubic tubercle when considered as a soft tissue attachment point. To clarify this issue, we dissected orangutan and other ape cadaveric specimens to evaluate the pelvic brim soft tissues and how they may relate to the tubercle (when present). We additionally conducted a broad osteological survey of pelvic brim morphology across 28 primate genera …

An Ensemble Of Flexible Conformations Underlies Mechanotransduction By The Cadherin–Catenin Adhesion Complex, Martin Bush, Bashir M. Alhanshali, Shuo Qian, Christopher B. Stanley, William T. Heller, Tsutomu Matsui, Thomas M. Weiss, Iain D. Nicholl, Thomas Walz, David J. E. Callaway, Zimei Bu

Publications and Research

The cadherin–catenin adhesion complex is the central component of the cell–cell adhesion adherens junctions that transmit mechanical stress from cell to cell. We have determined the nanoscale structure of the adherens junction complex formed by the α-catenin•β-catenin•epithelial cadherin cytoplasmic domain (ABE) using negative stain electron microscopy, small-angle X-ray scattering, and selective deuteration/small-angle neutron scattering. The ABE complex is highly pliable and displays a wide spectrum of flexible structures that are facilitated by protein-domain motions in α- and β-catenin. Moreover, the 107-residue intrinsically disordered N-terminal segment of β-catenin forms a flexible “tongue” that is inserted into α-catenin and participates in the …

Examining Public Opinion About Lgbtq-Related Issues In The United States And Across Multiple Nations, Amy Adamczyk, Yen-Chiao Liao

Publications and Research

Over the last three decades many countries across the world, including the United States, have experienced major increases in support for LGBTQ individuals and related issues. In part related to these changes a number of studies have examined the factors shaping public opinion. In this review we focus on four major areas of research on public opinion in this field of study. We first assess the terms that scholars typically use when examining attitudes and highlight the areas of public opinion research that have received the most attention. We then focus on the data and measurement challenges related to examining …

Engaging The Framework For Information Literacy For Higher Education As A Lens For Assessment In Eportfolio Social Pedagogy Ecosystem For Science Teacher Education, Wesley Pitts, Alison Lehner-Quam

Publications and Research

This article highlights a case study that assesses how graduate-level, in-service science teachers engage in an ePortfolio social pedagogy ecosystem to document their growth in knowledge practices and dispositions in information literacy. The ePortfolio social pedagogy ecosystem and this study are situated within the context of the Catalyst Framework. The three modes of interrelated social learning activities include: (1) authoring the written ePortfolio in an online ePortfolio digital media platform, (2) presenting the ePortfolio in the webinar platform, and (3) presenting the ePortfolio in- person in a physical setting. We used case study methodology to systematically investigate how each participant …

The Role Of The Literacy Coach: Where We Were And Where We’Re Going, Adam Ulenski, Jennifer Van Allen

Publications and Research

No abstract provided.

Response To "From A Polemic Paradox To A Proper Perspective Of Job Burnout And Job Satisfaction, Eric Laurent, Irvin Sam Schonfeld, Renzo Bianchi

Publications and Research

Juárez García and colleagues considered that “part of the conceptual and empirical problem of burnout is that many researchers force it into a biomedical disease model despite its being a psychosocial one.” Problematically, these authors’ scholastic argument a priori excludes biological or bodily factors from psychological conceptualizations. Scientists usually face considerable difficulties when trying to describe complex processes. If the understanding of biological processes sheds light on the complex processes that bear on burnout, then there is no reason to exclude research on those processes.

Comparative Characteristics Of Antibacterial Activity Of Plants Growing In The Central Part Of The Republic Of Tajikistan., Saidbeg Satorov, F. Mirzoeva, Sh. Satorov, M. Vakhidova, Vyacheslav Dushenkov

Publications and Research

Objective: To evaluate the spectrum of antibacterial activity of plants growing in the central part of the Republic of Tajikistan.
Methods: The antibacterial properties of 18 plant species from the 14 families were studied. The extract samples on dry filter discs were prepared according to the method developed at Rutgers University. Screens-to-Nature (STN) and disc diffusion (DD) methods were used to assess antimicrobial properties of the extracts. The antimicrobial activity of plant extracts was determined against four types of pathogenic standard museum strains of Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, as well as …

"Free Indirect Suicide: An Unfinished Fugue In H Minor", Seo-Young J. Chu

Publications and Research

In this lyric essay/work of creative nonfiction (listed among “Notable Essays & Literary Nonfiction” in Best American Essays 2020), Seo-Young Chu uses poetry, autotheory, and creative nonfiction to explore the generational trauma/postmemory han she inherited from her parents and the importance of destigmatizing mental illness through dialogue.

Historical Ecology And Longitudinal Research Strategies Around Lake Mývatn Iceland, Thomas Mcgovern, George Hambrecht, Megan Hicks

Publications and Research

Historical Ecology has proven to be a very influential tool kit for thinking about complex human interactions with changing landscapes, climate, and other humans. It has also provided concrete and practical frameworks for carrying out sustained long- term place-based research projects that break through traditional periodization to look at the dialectical interaction of human economies and local and regional ecosystems through time. The “longitudinal perspective” pioneered by Carole Crumley’s work in Burgundy has proved to be a very effective tool for carrying out sustained multi-year, multi-investigator, and multi- generational investigations in landscapes around the globe. This paper presents an overview …

Communication Training’S Higher Calling: Using A Civic Frame To Promote Transparency And Elevate The Value Of Services, Don Waisanen

Publications and Research

Communication trainers can make a greater case for their work by positioning all of their training, at its highest level, within a civic frame. A civic frame raises the stakes for training components such as listening or diversity and puts the benefits of corporate social responsibility and similar efforts into practice in training contexts. This chapter details why and how trainers can use this frame to create transparency and elevate the value of their services.

Inequality In Education, Judith R. Kafka

Publications and Research

This chapter reviews research on the history of inequality in education. Across the globe and since the advent of formal schooling, children from wealthier families have had access to more education, and more costly education, than their less affluent peers. More physically and intellectually advantaged children have also, on average, had greater educational opportunities than their less fortunate peers. Yet within this general historic truth lies considerable variation in terms of how, to what extent, and by what political justification educational inequalities have existed and persisted. Historians have sought to explain variations in inequality in education across time and place …

Gender Disparities In Awards To Neuroscience Researchers, David Melnikoff, Virginia Valian

Publications and Research

Women in academia receive fewer prestigious awards than their male counterparts. Why this gender gap emerges, however, remains poorly understood. Thus, we tested multiple hypotheses about the proximate cause of the gender gap in award prestige. Our findings suggest that the gender gap in award prestige may emerge in part from gender schemas that portray women as warmer and less competent than men. Specifically, our results are consistent with the hypothesis that gender schemas lead to women’s papers receiving fewer citations than men’s papers, which in turn results in more prestigious awards for men than for women. Additionally, our results …

Clinic-Based Delivery Of The Young Men’S Health Project (Ymhp) Targeting Hiv Risk Reduction And Substance Use Among Young Men Who Have Sex With Men: Protocol For A Type 2, Hybrid Implementation-Effectiveness Trial, Jeffrey T. Parsons, Tyrel Starks, Sitaji Gurung, Demetria Cain, Jonathan Marmo, Sylvie Naar

Publications and Research

Background: Young men who have sex with men (YMSM) are disproportionately at risk for HIV and sexually transmitted infections. Adapting and testing the effectiveness of the Young Men’s Health Project (YMHP), an efficacious intervention designed to reduce substance use and condomless anal sex (CAS) among YMSM, at clinics in Miami, Detroit, and Philadelphia has the potential to reduce HIV and STI disparities among urban YMSM.

Objective: This study (Adolescent Medicine Trials Network for HIV/AIDS Interventions [ATN] 145 YMHP) aims to adapt YMHP for clinic and remote delivery by existing clinic staff and compare their effectiveness in real-world adolescent HIV clinics. …

Spinal Matrix Metalloproteinase 8 Regulates Pain After Peripheral Trauma, Maral Tajerian, J. David Clark

Publications and Research

It is well documented that pain chronification requires a host of plastic mechanisms at the spinal cord (SC) level, including alterations in neuronal and glial structure and function. Such cellular plasticity necessitates the existence of a plastic extracellular matrix(ECM). Here, we describe a key role for ECM remodeling in the regulation of chronic pain following peripheral injury. Three weeks following tibia fracture in mice, we show increased levels of MMP8 in the SC. Furthermore, we show that the pharmacological or genetic downregulation of MMP8 ameliorates the pain phenotype observed after injury. These results delineate an extracellular mechanism for pain chronification, …

Does Widowhood Affect Cognitive Function Among Chinese Older Adults?, Zhenmei Zhang, Lydia W. Li, Hongwei Xu, Jinyu Liu

Publications and Research

There is growing evidence from Western countries that widowhood may affect cognitive health in later life. However, little is known about whether widowhood isassociated with cognitive health in Eastern Asian countries such as China and what factors may explain the association between widowhood and cognitive health. Weadd to this line of research by investigating the effect of widowhood on 2-year change in cognitive function among Chinese adults ages 55 and older from 2011 to2013, using data from the China Health and Retirement Longitudinal Study. Cognitive function was measured by episodic memory and mental intactness (i.e.,attention and time orientation). Our results …