Digital Commons Network^™

The Impact Of A Supplemental Instruction Program On Diverse Peer Leaders At A Two-Year Institution, Sarah Hoiland, Silvia Reyes, Antonio Varelas

Publications and Research

Supplemental Instruction (SI) is a peer-led academic support program in which SI Leaders help students develop study habits and note-taking strategies as well as facilitate test preparation. While the effects of SI on students receiving the instruction have been thoroughly investigated, there have been far fewer studies that have assessed the impact of SI on its Leaders. Furthermore, research on Leaders has yet to adequately consider community colleges or Hispanic-Serving Institutions (HSIs), or to employ qualitative methodologies. Thus, this paper details an SI program developed at a two-year HSI and the impact of the SI Leaders’ experience via qualitative data …

Federalism As A Double-Edged Sword: The Slow Energy Transition In The United States, Roger Karapin

Publications and Research

Much literature on federalism and multi-level governance argues that federalist institutional arrangements promote renewable-energy policies. However, the U.S. case supports a different view, that federalism has ambivalent effects. Policy innovation has occurred at the state level and to some extent has led to policy adoption by other states and the federal government, but the extent is limited by the veto power of fossil-fuel interests that are rooted in many state governments and in Congress, buttressed by increasing Republican Party hostility to environmental and climate policy. This argument is supported by a detailed analysis of five periods of federal and state …

Triflic Acid Mediated Sequential Cyclization Of Ortho-Alkynylarylesters With Ammonium Acetate, Maciej E. Domaradzki, Xiaochen Liu, Jiye Ong, Gyeongah Yu, Gan Zhang, Ariel Simantov, Eliyahu Perl, Yu Chen

Publications and Research

A triflic acid (TfOH) mediated sequential cyclization of ortho-alkynylarylesters and ammonium acetate (NH₄OAc) was reported. The reaction took place via a Brønsted acid-mediated intramolecular cyclization of ortho-alkynylarylesters followed by an ammonium acetate participated substitution reaction, forming isoquinolin-1-ones as the major products. Different from most of the known synthetic methods of isoquinolin-1-ones, no metal catalyst was required in the reported reaction. The regioisomers – isoindolin-1-ones were obtained together with isoquinolin-1-ones in a few cases. The intermediate compounds – isochromen-1-ones and isobenzofuran-1-ones were also isolated. The interconversion experiments showed that the regioisomers formed during the Brønsted acid induced …

Barrels Xxxii Meeting Report: Whiskers In The Windy City, Giuseppe Cataldo, Chia-Chien Chen, Alicia C. Barrientos, Joshua C. Brumberg

Publications and Research

The 32^nd Annual Barrels meeting was hosted at the Northwestern University Feinberg School of Medicine in Chicago, Illinois on October 17^th and 18^th, 2019. The annual meeting brings together researchers who utilize the rodent whisker-to-barrel system as a means to understand cortical function and development. This year’s meeting focused on social behaviors, development and cerebellar functions within the barrel system and beyond.

Learning And Motivation For Rewards In Schizophrenia: Implications For Behavioral Rehabilitation, Victoria Martin, Alexandra Brereton, Jicheng Tang

Publications and Research

Purpose of review: Impaired reward processing and amotivation are well documented in schizophrenia. We aim to review the current state of neuroimaging and behavioral research addressing components of motivational deficits in this complex and impairing syndrome. Evidence will be integrated to inform the ongoing development of effective strategies for behavioral rehabilitation. Recent findings: While striatal dopamine and aberrant reward prediction errors have been connected to amotivation in schizophrenia, they are not sufficiently full explanations of reward processing impairments. Frontal dysfunction and associated cognitive control deficits also have evidenced involvement in atypical reward prediction, learning, and valuation. Ongoing work supports the …

Keynesian Uncertainty: The Great Divide Between Joan Robinson And Paul Samuelson In Their Correspondence And Public Exchanges, Harvey Gram, G. C. Harcourt

Publications and Research

Joan Robinson and Paul Samuelson found little to agree upon in a correspondence which began in 1946, shortly after the death of Keynes, and ended a year prior to Robinson’s death in 1983. One way to read the correspondence is to keep in mind that Keynesian uncertainty was central to Robinson’s understanding of how capitalist economies function. Samuelson, never impressed by Keynes’s handling of uncertainty, understood capital theory—if not capitalism—in terms of dynamic programming, with its perfect foresight entailments. This is evident throughout his letters to Robinson, although rarely acknowledged in a straightforward way, particularly during the period from 1971 …

Characterization Of Women And Leadership In Public Administration And Beyond, Maria J. D'Agostino, Meghna Sabharwal, Helisse Levine

Publications and Research

Women were 30% of the labor force in 1950 and 48.6% of the workforce today. Women are also currently outpacing men in the attainment of college degrees – 36% of women aged between 25- 29 years have a bachelor’s degree compared to 28% of males in the same age group and have surpassed men in college graduation rates. Despite these growing numbers, women have yet to reach a critical mass in leadership positions. Women represent less than 5% of CEOs in Fortune 500 companies. Out of 195 state heads around the world, only 15 are currently women. Less than 20% …

Teaching In A Flipped Classroom., Jillian Grose-Fifer

Publications and Research

In this chapter, I describe how I switched to using a flipped class model in an upper-level Sensation and Perception course, by reversing where different types of learning take place. In the flipped model, instead of introducing students to basic concepts in class, they answered guiding questions after watching videos or reading the textbook before attending class. They then spent class time working collaboratively in small groups on more challenging assignments, many of which had been homework assignments in prior (non-flipped) courses. In-class activities consisted of mini-experiments, and other student-centered hands-on learning experiences designed to foster higher-order critical thinking and …

Student Success In Psychology-English Learning Communities., Jillian Grose-Fifer, Kimberly A. Helmer

Publications and Research

Participation in a learning community has been widely recognized as a high impact educational practice. Here, we focus on a highly successful partnership between a psychology professor (JGF) and an English professor (KAH), who codesigned and cotaught a first-year cocurricular (Psychology/English Composition) learning community (LC) course for multiple semesters at a large public Minority/Hispanic Serving Institution in the Northeast. We describe how we created co-curricular links between our courses, which hinged in part on a collaborative podcast assignment based on psychology-themed books. We detail how we built a strong sense of community, designed scaffolded assignments targeting skills, such as information …

Analysis Of Adult Neural Retina Extracellular Vesicle Release, Rna Transport And Proteomic Cargo, Jason Mighty, Jing Zhou, Alberto Benito-Martin, Sami Sauma, Samer Hanna, Onyekwere Onwumere, Cui Shi, Martin Muntzel, Moira Sauane, Michael Young, Henrik Molina, Dianne Cox, Stephen Redenti

Publications and Research

PURPOSE. Extracellular vesicles (EVs) contain RNA and protein cargo reflective of the genotype and phenotype of the releasing cell of origin. Adult neural retina EV release, RNA transfer, and proteomic cargo are the focus of this study.

METHODS. Adult wild-type mouse retinae were cultured and released EV diameters and concentrations quantified using Nanosight. Immunogold transmission electron microscopy (TEM) was used to image EV ultrastructure and marker protein localization. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to analyze retinal cell transcripts present in EVs. Super-resolution microscopy was used to image fluorescent (green) RNA and (red) lipid membrane labeled EVs, released …

Protecting Public Health, Susan H. Davide, Christine Macarelli, Anty Lam

Publications and Research

In light of declining vaccination rates, oral health professionals need to be knowledgeable about current vaccine recommendations so they can best advise their patients and support public health.

Panpsychism As An Observational Science, Gregory Matloff

Publications and Research

The metaphysical concept of panpsychism defines a field of proto-consciousness that is present at all levels in the universe. An observational indication that this concept might be correct is self-organization on all levels from the molecular to the galactic. In 2011, an investigation into the validity of author Olaf Stapledon’s concept that a portion of stellar motion is volitional led to a consideration of an observational stellar kinematics anomaly dubbed Parenago’s Discontinuity. Data available at the time indicated that cooler, less massive stars (such as the Sun) revolve a bit faster around the center of the Milky Way galaxy than …

A Kinesin Adapter Directly Mediates Dendritic Mrna Localization During Neural Development In Mice, Hao Wu, Jing Zhou, Tianhui Zhu, Ivan Cohen, Jason Dictenberg

Publications and Research

Motor protein-based active transport is essential for mRNA localization and local translation in animal cells, yet how mRNA granules interact with motor proteins remains poorly understood. Using an unbiased yeast two–hybrid screen for interactions between murine RNA-binding proteins (RBPs) and motor proteins, here we identified protein interaction with APP tail-1 (PAT1) as a potential direct adapter between zipcode-binding protein 1 (ZBP1, a β-actin RBP) and the kinesin-I motor complex. The amino acid sequence of mouse PAT1 is similar to that of the kinesin light chain (KLC), and we found that PAT1 binds to KLC directly. Studying PAT1 in mouse …

Leveraging Technology To Blend Large-Scale Epidemiologic Surveillance With Social And Behavioral Science Methods: Successes, Challenges, And Lessons Learned Implementing The Unite Longitudinal Cohort Study Of Hiv Risk Factors Among Sexual Minority Men In The United States, H. Jonathon Rendina, Ali J. Talan, Nicola F. Tavella, Jonathan Lopez Matos, Ruben H. Jimenez, S. Scott Jones, Brian Salfas, Drew Westmoreland

Publications and Research

The use of digital technologies to conduct large-scale research with limited interaction (i.e., no in-person contact) and objective endpoints (i.e., biological testing) has significant potential for the field of epidemiology, but limited research to date has been published on the successes and challenges of such approaches. We analyzed data from a cohort study of sexual minority men across the United States, collected using digital strategies during a 10-month period from 2017 to 2018. Overall, 113,874 individuals were screened, of whom 26,000 were invited to the study, 10,691 joined the study, and 7,957 completed all enrollment steps, including return of a …

Supporting Undergraduate Underrepresented Minority Students For Success In Stem, Nadia Kennedy, Urmi Ghosh-Dastidar, Sandie Han, Diana Samaroo, Armando Solis

Publications and Research

This presentation reports on a model for engaging, retaining, and supporting undergraduate STEM students, and in particular women and underrepresented minorities (URM), which aims at: recruitment of students in the STEM disciplines and in particular URM students; increased persistence of students; increased graduation rates, and shortened time to graduation. The model has been tested and found to be successful at an urban northeastern university in the USA that has been designated as a Hispanic-serving institution. In this presentation, we describe this model, built from support strategies that include mandatory academic advisement; increased exposure to early research experiences; expanded one-on-one faculty …

Libraries And Their Publics In The United States, Maura A. Smale

Publications and Research

No abstract provided.

Dark-Binding Process Relevant To Preventing Photosensitized Oxidation: Conformation-Dependent Light And Dark Mechanisms By A Dual-Functioning Diketone, Sarah J. Belh, Niluksha Walalawela, Stas Lekhtman, Alexander Greer

Publications and Research

Few photosensitizers function in both light and dark processes as they usually have no function when the lights are turned off. We hypothesized that light and dark mechanisms in an α-diketone will be decoupled by dihedral rotation in a conformation- dependent binding process. Successful decoupling of these two functions is now shown. Namely, anti- and syn-skewed conformations of 4,4′-dimethylbenzil promote photosensitized alkoxy radical production, whereas the syn conformation promotes a binding shutoff reaction with trimethyl phosphite. Less rotation of the diketone is better suited to the photosensitizing function since phosphite binding arises through the syn conformer of lower stability. The …

A Bifunctional Atpase Drives Tad Pilus Extension And Retraction, Courtney K. Ellison, Jingbo Kan, Jennifer L. Chlebek, Katherine R. Hummels, GaёL Panis, Patrick H. Viollier, Nicolas Biais, Ankur B. Dalia, Yves V. Brun

Publications and Research

A widespread class of prokaryotic motors powered by secretion motor adenosine triphosphatases (ATPases) drives the dynamic extension and retraction of extracellular fibers, such as type IV pili (T4P). Among these, the tight adherence (tad) pili are critical for surface sensing and biofilm formation. As for most other motors belonging to this class, how tad pili retract despite lacking a dedicated retraction motor ATPase has remained a mystery. Here, we find that a bifunctional pilus motor ATPase, CpaF, drives both activities through adenosine 5′-triphosphate (ATP) hydrolysis. We show that mutations within CpaF result in a correlated reduction in the rates of …

The Impact Of Callous-Unemotional Traits And Externalizing Tendencies On Neural Responsivity To Reward And Punishment In Healthy Adolescents, Yonglin Huang, Tingting Wu, Yu Gao, Yuyang Luo, Ziyan Wu, Shawn Fagan, Stephanie Leung, Xiaobo Li

Publications and Research

Both externalizing behavior and callous-unemotional (CU) traits in youth are precursors to later criminal offending in adulthood. It is posited that disruptions in reward and punishment processes may engender problematic behavior, such that CU traits and externalizing behavior may be linked to a dominant reward response style (e.g., heightened responsivity to rewards) and deficient punishment-processing. However, prior research has generated mixed findings and work examining both the sole and joint contribution of CU traits and externalizing problems related to functional brain alterations is lacking. In this pilot functional magnetic resonance imaging study, we measured externalizing behavior and CU traits in …

Visual Modulation Of Resting State Α Oscillations, Kelly Webster, Tony Ro

Publications and Research

Once thought to simply reflect passive cortical idling, recent studies have demonstrated that α oscillations play a causal role in cognition and perception. However, whether and how cognitive or sensory processes modulate various components of the α rhythm is poorly understood. Sensory input and resting states were manipulated in human subjects while electroencephalography (EEG) activity was recorded in three conditions: eyes-open fixating on a visual stimulus, eyes-open without visual input (darkness), and eyes-closed without visual input (darkness). We show that α power and peak frequency increase when visual input is reduced compared to the eyes open, fixating condition. These results …

Visualization And Analysis Of Environmental Data, Sean Macdonald

Publications and Research

The virtual exploration of place has been employed in a variety of learning environments across many disciplines, creatively expanding upon the experience of place. This chapter explores the value of mapping environmental data as a tool that can enhance students’ virtual exploration of place as they investigate local environmental policies and problems within their own urban surroundings. This visualization project engages students in making meaningful connections between the theoretical study of local and global environmental problems and the “observation” and investigation of these data using mapped data. The virtual learning environment is viewed as one that is interactive, exploring how …

Building Mof Nanocomposites With Oxidized Graphitic Carbon Nitride Nanospheres: The Effect Of Framework Geometry On The Structural Heterogeneity, Dimitrios A. Giannakoudakis, Teresa J. Bandosz

Publications and Research

Composite of two MOFs, copper-based Cu-BTC (HKUST-1) and zirconium-based Zr-BDC (UiO-66), with oxidized graphitic carbon nitride nanospheres were synthesized. For comparison, pure MOFs were also obtained. The surface features were analyzed using x-ray diffraction (XRD), sorption of nitrogen, thermal analysis, and scanning electron microscopy (SEM). The incorporation of oxidized g-C3N4 to the Cu-BTC framework caused the formation of a heterogeneous material of a hierarchical pores structure, but a decreased surface area when compared to that of the parent MOF. In the case of UiO-66, functionalized nanospheres were acting as seeds around which the crystals grew. Even though the MOF phases …

The Ethical Implications Of Bioengineering Advancements, Mainstream Media Coverage Of Those Developments, And The Future Of Motherhood, Aliff Abad, Katherine Gregory

Publications and Research

How do the media interpret reproductive interventions that involve genetic testing? When a scientist performed the first known genetic editing on twins, Lulu and Nana, he ignored ethical considerations of CRISPR use. This project provides a content analysis based on a review of popular science and newspaper articles. Our interpretation of these articles suggest that there is a lack of critical understanding of this unethical procedure and a similar attitude towards future genetic developments. While the public is curious about the repercussions of genetic editing, not enough focus is applied to the ethics of conducting such a procedure.

Low-Cost Near Infrared Diffuse Optical Imaging System, Mohammed Z. Shakil, Chen Xu

Publications and Research

Diffuse Optical Tomography (DOT) and Optical Spectroscopy using near-infrared (NIR) diffused light has demonstrated great potential for the initial diagnosis of tumors and in the assessment of tumor vasculature response to neoadjuvant chemotherapy. The NIR technique utilizes intrinsic hemoglobin contrast, which is directly related to tumor angiogenesis development, a key process required for tumor growth and metastasis. The NIR diffuse tomography holds great promise in distinguishing early-stage invasive breast cancers from benign lesions. This technique also provides insight into tumor metabolism and tumor hypoxia, important indicators of tumor response to various forms of therapy. Currently, the high cost of the …

Fabrication And Imaging Characterization Of Poly (Dimethyl Siloxane)/Sic Nano-Fillers Samples As Model Biomaterials, Tetiana Soloviova, Viorica Gutu, Zoya Vinokur, Akm S. Rahman, Subhendra Sarkar

Publications and Research

Biopolymers are being developed with embedded nanostructures for in vivo drug delivery to treat various diseases including cancers. In the current project we developed fabrication steps to prepare two biopolymers, poly di-methoxy siloxane (PDMS) with 0-0.9 vol% of SiC nano whisker (fillers) followed by non- destructive characterization. Optical reflection microscopy (5-100X) was performed to ensure loading and distribution of increasing SiC content. Optical microscopy showed progressively higher SiC distribution as filler loading was increased from 0-0.9 vol%. X-ray imaging at low kV (kilovoltage) and low mAs (milliamperage per second) were optimized to allow distinction between filled PDMS with SiC concentration …

Children’S Gender And Investments From Nonresident Fathers, Kristin Mammen

Publications and Research

Evidence suggests that fathers have stronger ties to sons than daughters, which may result in differential investments in their children. This paper investigated whether girls’ gender restricts their access to fathers' contributions if they do not live together. The data used were the 1994-2008 March/April Match Current Population Survey Child Support Supplements, a large, nationally representative sample which identifies child support eligible mothers of all marital statuses and collects information on nonresident fathers’ financial and social investments in their children. Results for court-mediated outcomes such as the existence and amounts of child support orders showed that courts do not allocate …

Convergence Of Human And Old World Monkey Gut Microbiomes Demonstrates The Importance Of Human Ecology Over Phylogeny, Katherine R. Amato, Elizabeth K. Mallott, Daniel Mcdonald, Nathaniel J. Dominy, Tony Goldberg, Joanna E. Lambert, Larissa Swedell, Jessica L. Metcalf, Andres Gomez, Gillian A. O. Britton, Rebecca M. Stumpf, Steven R. Leigh, Rob Knight

Publications and Research

Background

Comparative data from non-human primates provide insight into the processes that shaped the evolution of the human gut microbiome and highlight microbiome traits that differentiate humans from other primates. Here, in an effort to improve our understanding of the human microbiome, we compare gut microbiome composition and functional potential in 14 populations of humans from ten nations and 18 species of wild, non-human primates.

Results

Contrary to expectations from host phylogenetics, we find that human gut microbiome composition and functional potential are more similar to those of cercopithecines, a subfamily of Old World monkey, particularly baboons, than to those …

Tamoxifen Activity Against Plasmodium In Vitro And In Mice, Ada Weinstock, Julio Gallego-Delgado, Cláudia Gomes, Julian Sherman, Cyrus Nikain, Sandra Gonzalez, Edward Fisher, Ana Rodriguez

Publications and Research

Background: Tamoxifen is an oestrogen receptor modulator that is widely used for the treatment of early stage breast cancer and reduction of recurrences. Tamoxifen is also used as a powerful research tool for controlling gene expression in the context of the Cre/loxP site-specific recombination system in conditional mutant mice.

Methods: To determine whether the administration of tamoxifen affects Plasmodium growth and/or disease outcome in malaria, in vitro studies assessing the effect of tamoxifen and its active metabolite 4-hydroxytamoxifen on Plasmodium falciparum blood stages were performed. Tamoxifen effects were also evaluated in vivo treating C57/B6 mice infected with Plasmodium berghei (ANKA …

Case Presentation On Urinary Bladder Cancer And Cysto-Prostatectomy, Tetiana Soloviova

Publications and Research

Patients who have invasive bladder cancer (spread to different tissues and organs) may need to have a radical cystectomy type of surgery. In male patients, the surgeon usually removes the prostate and seminal vesicles in addition to the bladder, parts of the ureters, and lymph nodes (Nicholson, 2017, ¶ 1)

In our case a reconstructive surgery followed right after removing of the bladder and prostate gland. A different way of urine to be stored and passed from the patient’s body was created by the surgeon. A part of small intestine was used to make up a reservoir that will serve …

Static Solid Relaxation Ordered Spectroscopy: Ss-Rosy, Gregory S. Boutis, Ravinath Kausik

Publications and Research

A two-dimensional pulse sequence is introduced for correlating nuclear magnetic resonance anisotropic chemical shifts to a relaxation time (e.g., T1) in solids under static conditions. The sequence begins with a preparatory stage for measuring relaxation times, and is followed by a multiple pulse sequence for homonuclear dipolar decoupling. Data analysis involves the use of Fourier transform, followed by a one-dimensional inverse Laplace transform for each frequency index. Experimental results acquired on solid samples demonstrate the general approach, and additional variations involving heteronuclear decoupling and magic angle spinning are discussed.