Digital Commons Network^™

Comparison Of Blood Lactate And Perceived Exertion Responses In Two Matched Time-Under- Tension Protocols, Salvador Vargas-Molina, Fernando Martín-Rivera, Diego A. Bonilla, Jorge L. Petro, Leandro Carbone, Ramón Romance, Manuel Dediego, Brad J. Schoenfeld, Javier Benítez-Porres

Publications and Research

Purpose: The aim of this study was to compare the concentration of blood lactate [bLa-] and the subjective perception of exertion of trained men in a moderate repetition protocol (MRP) versus a high repetition protocol (HRP) equated for time under tension.

Methods: A sample of 40 healthy young men (aged, 23.2 ± 4.0 years; height, 177.3 ± 7.0 cm; BMI, 24.3 ± 2.2) performed two sessions of 8 sets of bicep curls with a one-week recovery interval between the trials. In the HRP protocol, 20 repetitions were performed with a cadence of 2 seconds of eccentric and 1 …

Enhanced Tes And Tdcs Computational Models By Meninges Emulation, Jimmy Jiang, Dennis Q. Truong, Zeinab Esmaeilpour, Yu Huang, Bashar W. Badran, Marom Bikson

Publications and Research

Objective. Understanding how current reaches the brain during transcranial electrical stimulation (tES) underpins efforts to rationalize outcomes and optimize interventions. To this end, computational models of current flow relate applied dose to brain electric field. Conventional tES modeling considers distinct tissues like scalp, skull, cerebrospinal fluid (CSF), gray matter and white matter. The properties of highly conductive CSF are especially important. However, modeling the space between skull and brain as entirely CSF is not an accurate representation of anatomy. The space conventionally modeled as CSF is approximately half meninges (dura, arachnoid, and pia) with lower conductivity. However, the resolution …

Exploring The Potential Of Nitric Oxide And Hydrogen Sulfide (Nosh)-Releasing Synthetic Compounds As Novel Priming Agents Against Drought Stress In Medicago Sativa Plants, Chrystalla Antoniou, Rafaella Xenofontos, Giannis Chatzimichail, Anastasis Christou, Khosrow Kashfi, Vasileios Fotopoulos

Publications and Research

Land plants are continuously exposed to multiple abiotic stress factors like drought, heat, and salinity. Nitric oxide (NO) and hydrogen sulfide (H2S) are two well-examined signaling molecules that act as priming agents, regulating the response of plants to stressful conditions. Several chemical donors exist that provide plants with NO and H2S separately. NOSH is a remarkable novel donor as it can donate NO and H2S simultaneously to plants, while NOSH-aspirin additionally provides the pharmaceutical molecule acetylsalicylic acid. The current study aimed to investigate the potential synergistic effect of these molecules in drought-stressed Medicago sativa L. plants by following a pharmacological …

Prenatal Choline Supplementation During High-Fat Feeding Improves Long-Term Blood Glucose Control In Male Mouse Offspring, Hunter W. Korsmo, Kaydine Edwards, Bhoomi Dave, Chauntelle Jack-Roberts, Huanling Yu, Anjana Saxena, Marie Salvador, Moshe Dembitzer, Jaskomal Phagoora, Xinyin Jiang

Publications and Research

Maternal obesity increases the risk of metabolic dysregulation in rodent offspring, especially when offspring are exposed to a high-fat (HF), obesogenic diet later in life. We previously demonstrated that maternal choline supplementation (MCS) in HF-fed mouse dams during gestation prevents fetal overgrowth and excess adiposity. In this study, we examined the long-term metabolic influence of MCS. C57BL/6J mice were fed a HF diet with or without choline supplementation prior to and during gestation. After weaning, their pups were exposed to either a HF or control diet for 6 weeks before measurements. Prenatal and post-weaning dietary treatments led to sexually dimorphic …

Water In Your Neighbourhood: A Model For Implementing A Semester-Long Course-Based Undergraduate Research Project In Introductory Biology, Ana Lucia Fuentes, Maria Entezari

Publications and Research

Undergraduate biology education has changed over the past decade, incorporating an iterative and evidence-based approach. Many educational assessments have confirmed the effectiveness of integrating authentic research and open-ended inquiry into introductory biology courses, demonstrating a significant positive impact on students’ learning and attitude towards STEM majors. Despite these findings, only a handful of Biology instructors in 2-year colleges adopt this approach, and when adopted, most activities constitute a small fraction of these courses. Finding a feasible, sustainable, semester-long, and cost-effective strategy to incorporate authentic research in the curriculum which promotes integrated understanding of science and addresses socio-scientific issues, is a …

Cis-Regulatory Analysis Of Onecut1 Expression In Fate-Restricted Retinal Progenitor Cells, Sruti Patoori, Nathalie Jean-Charles, Ariana Gopal, Sacha Sulaiman, Sneha Gopal, Brian Wang, Benjamin Souferi, Mark Emerson

Publications and Research

Background: The vertebrate retina consists of six major classes of neuronal cells. During development, these cells are generated from a pool of multipotent retinal progenitor cells (RPCs) that express the gene Vsx2. Fate-restricted RPCs have recently been identified, with limited mitotic potential and cell fate possibilities compared to multipotent RPCs. One population of fate-restricted RPCs, marked by activity of the regulatory element ThrbCRM1, gives rise to both cone photoreceptors and horizontal cells. These cells do not express Vsx2, but co-express the transcription factors (TFs) Onecut1 and Otx2, which bind to ThrbCRM1. The components of the gene regulatory networks that control …

Li Zehou: Synthesizing Kongzi, Marx, And Kant, Andrew Lambert

Publications and Research

To understand the details of Li Zehou’s work, it is helpful to first locate it within the social and historical contexts to which Li was responding. Specifically, his work can be understood as a contribution to the struggle to establish the intellectual foundations of a Chinese modernity. As China transitioned away from the long-lived dynastic system that had ended early in the twentieth century, there was intense debate in China about what forms of social and political order should take its place. Marxism emerged as the governing ideology after the Communist revolution, but this did not settle the outstanding social …

Using Site Visits To Strengthen Collaboration, Victor Piercey, Rebecca Segal, Afroditi Vennie Filippas, Tao Chen, Soloman Kone, Rosalyn Hobson Hargraves, Jack Bookman, John Hearn, Debbie Pike, Kathy S. Williams

Publications and Research

The SUMMIT-P project is a multi-institutional endeavor to leverage interdisciplinary collaboration in order to improve the teaching of undergraduate mathematics courses in the first two years of college. One goal of this work is to establish collaborative communities among the institutions involved. As part of the project, institutions visit one another on site visits that are structured according to a common protocol. The site visits have been valuable to the project. Participating institutions report the exchange of actionable ideas and feedback; members of the grant leadership team have used the site visits to direct the overall project, and evaluators have …

Fishbowl Discussions: Promoting Collaboration Between Mathematics And Partner Disciplines, Stella K. Hofrenning, Rosalyn Hobson Hargraves, Tao Chen, Afroditi Vennie Filippas, Rhonda Fitzgerald, John Hearn, Lori J. Kayes, Joan Kunz, Rebecca Segal

Publications and Research

A National Consortium for Synergistic Undergraduate Mathematics via Multi-institutional Interdisciplinary Teaching Partnerships project (SUMMIT-P) is a collaboration of institutions focused on revising first- and second-year mathematics courses with the help of partner disciplines with prerequisite mathematics courses. This paper describes the fishbowl discussion technique used by the consortium members to encourage interdisciplinary conversation. Vignettes describing the results of conversations that occurred at several consortium member institutions are provided by the co-authors.

A Multistep Inquiry Approach To Improve Pre-Service Elementary Teachers’ Conceptual Understanding, Lloyd Mataka, Rex Taibu

Publications and Research

A quasi-experimental control group pre- and post-test study was used to determine the effect of a Multi-Step Inquiry (MSI) approach on pre-service elementary school teacher‘s conceptual understanding. The MSI study involved the development of a conceptual workbook, and a Physical Science Concept Inventory. The conceptual workbook has activities that explicitly target students‘ misconceptions in physical science. The inventory has three categories: forces and motion, heat and temperature, and electricity. Descriptive and inferential statistics were used to interpret the data. Independent t-tests were used to compare the experimental and comparison groups. Further, Cohen‘s d and Hake‘s g effect sizes were used …

Sediment Microbiomes Associated With Critical Habitat Of The Juvenile American Horseshoe Crab; Limulus Polyphemus, J. Petersen, Christina P. Colon, J. L. Joyner

Publications and Research

Plumb Beach, Brooklyn, New York in USA is an important horseshoe crab breeding and nursery ground that has experienced substantial anthropogenic influence, including pollution, erosion and subsequent restoration. Since little is known about the relationship between sediment microbial communities and juvenile horseshoe crab survival, next generation sequencing was used to characterize and compare the sediment microbiome of three distinct areas of Plumb Beach:- a tidal creek with abundant juveniles, East Beach with moderate number of juveniles, and West Beach- a highly disturbed area where juvenile crabs are rarely seen. The microbiome of juvenile crab intestinal content (both dissected gut content …

Elucidation Of Putative Binding Partners For The Protein Encoded By Orf149 Of Cyprinid Herpesvirus 3 In Goldfish (Carassius Auratus), Simon Menanteau–Ledouble, Michael Gotesman, Ebrahim Razzazi‐Fazeli, Sven M. Bergmann, Mansour El‐Matbouli

Publications and Research

No abstract provided.

Lgbtq+ Civil Rights: Local Government Efforts In A Volatile Era, Nicole M. Elias

Publications and Research

LGBTQ+ issues at the local level pose some of the most pressing civil rights challenges in the current U.S.context. This analysis provides insight into what is taking place in major municipalities and how these efforts can be improved to bolster equity and civil rights for LGBTQ+ populations. At a time when identity, language, and public sector values are inherently intertwined and constantly changing, the following question is ripe for analysis: how are major U.S. municipalities addressing the civil rights needs of the LGBTQ+ population? To answer this question, an analysis of government websites from the top 10 U.S. cities by …

Evolving Into The Open: A Framework For Collaborative Design Of Renewable Assignments, Stacy Katz, Jennifer Van Allen

Publications and Research

Open pedagogy reconceives the notion of who creates knowledge and provides a pathway to empower students as creators. Leveraging open education resources in the classroom results in numerous benefits for students, including free access to knowledge, a participatory culture, and opportunities for innovation and creativity (Hegarty, 2015). Open pedagogical design often results in renewable course assignments, which empower students to create authentic resources that can be positioned to have greater impact through time, space, and gravity, particularly as they have longevity, reach, and value (Seraphin et al., 2018). In this chapter, we will highlight a collaborative partnership between library and …

Participatory Action Research In Schools: Unpacking The Lived Inequities Of High Stakes Testing, Tiffany A. Dejaynes, Tabatha Cortes, Israt Hoque

Publications and Research

Purpose – This paper aims to examine a school-based Youth Participatory Action Research (YPAR) project on educational inequity and high stakes testing.

Design/methodology/approach – A former high school teacher (currently a university professor) and two former students (currently research assistants and university students) take up a youth studies framework to collaboratively resee multimodal artifacts from a tenth-grade course in qualitative research.

Findings – Findings illustrate the power of finding allies in peers and educators; the transformative power of deep participation; and the longitudinal nature of social change and action. Thus, this research demonstrates that when students are positioned as researchers, …

Do The Anatomical And Physiological Properties Of A Muscle Determine Its Adaptive Response To Different Loading Protocols?, Brad J. Schoenfeld, Andrew D. Vigotsky, Jozo Grgic, Cody Haun, Bret Contreras, Kenneth Delcastillo, Aston Francis, Gilda Cote, Andrew Alto

Publications and Research

It has been proposed that superior muscle hypertrophy may be obtained by training muscles predominant in type I fibers with lighter loads and those predominant in type II fibers with heavier loads.

Purpose: To evaluate longitudinal changes in muscle strength and hypertrophy of the soleus (a predominantly slow-twitch muscle) and gastrocnemius (muscle with a similar composition of slow and fast-twitch fibers) when subjected to light (20–30 repetition maximum) and heavy (6–10 repetition maximum) load plantarflexion exercise.

Methods: The study employed a within-subject design whereby 26 untrained young men had their lower limbs randomized to perform plantarflexion with a low-load (LIGHT) …

"'In A Distant Unknown Country': A New Historicist Look At James Joyce’S “Eveline,” Argentina, And The Zwi Migdal In The Early 1900s.", M Laura Barberan Reinares

Publications and Research

This article analyzes James Joyce’s story “Eveline” (1904) looking at the moral panic about “white slavery” in Europe and the new continent, especially focusing on Argentina, the foremost recipient of trafficked women between 1880 and 1930 (and, of course, Joyce’s destination of choice for Eveline). It was precisely at the turn of the twentieth century that, along with the popularity of transatlantic migration, sex trafficking went fully global and news about international “dangers” for single white women reached the general public, provoking all kinds of repressive reactions through what became known as the “social purity” movement.

A Review Of Small Molecule Inhibitors And Functional Probes Of Human Cathepsin L, Dibyendu Dana, Sanjai Kumar

Publications and Research

Human cathepsin L belongs to the cathepsin family of proteolytic enzymes with primarily an endopeptidase activity. Although its primary functions were originally thought to be only of a housekeeping enzyme that degraded intracellular and endocytosed proteins in lysosome, numerous recent studies suggest that it plays many critical and specific roles in diverse cellular settings. Not surprisingly, the dysregulated function of cathepsin L has manifested itself in several human diseases, making it an attractive target for drug development. Unfortunately, several redundant and isoform-specific functions have recently emerged, adding complexities to the drug discovery process. To address this, a series of chemical …

Network Structure Of Vertebrate Scavenger Assemblages At The Global Scale: Drivers And Ecosystem Functioning Implications, Esther Sebastián-González, Zebensui Morales-Reyes, Francisco Botella, Lara Naves-Alegre, Juan M. Pérez-García, Patricia Mateo-Tomás, Pedro P. Olea, Marcos Moleón, Jomar M. Barbosa, Fernando Hiraldo, Eneko Arrondo, José A. Donázar, Ainara Cortés-Avizanda, Nuria Selva, Sergio A. Lambertucci, Aishwarya Bhattacharjee, Alexis L. Brewer, Erin F. Abernethy, Kelsey L. Turner, James C. Beasley, Travis L. Devault, Hannah C. Gerke, Olin E. Rhodes Jr, Andrés Ordiz, Camilla Wikenros, Barbara Zimmermann, Petter Wabakken, Christopher C. Wilmers, Justine A. Smith, Corinne Kendall, Darcy Ogada, Ethan Frehner, Maximilian L. Allen, Heiko U. Wittmer, James R. A. Butler, Johan T. Du Toit, Antoni Margalida, Pilar Oliva-Vidal, David Wilson, Klemen Jerina, Miha Krofel, Rich Kostecke, Richard Inger, Esra Per, Yunus Ayhan, Hasan Ulusoy, Doğanay Vural, Akino Inagaki, Shinsuke Koike, Arockianathan Samson, Paula L. Perrig, Emma Spencer, Thomas M. Newsome, Marco Heurich, José D. Anadón, Evan R. Buechley, José A. Sánchez-Zapata

Publications and Research

The organization of ecological assemblages has important implications for ecosystem functioning, but little is known about how scavenger communities organize at the global scale. Here, we test four hypotheses on the factors affecting the network structure of terrestrial vertebrate scavenger assemblages and its implications on ecosystem functioning. We expect scavenger assemblages to be more nested (i.e. structured): 1) in species-rich and productive regions, as nestedness has been linked to high competition for carrion resources, and 2) regions with low human impact, because the most efficient carrion consumers that promote nestedness are large vertebrate scavengers, which are especially sensitive to human …

Higher Sensitivity Of Female Cells To Ethanol: Methylation Of Dna Lowers Cyp2e1, Generating More Ros, Carlos G. Penaloza, Mayra Cruz, Gabrielle Germain, Sidra Jabeen, Mohammad Javdan, R. A. Lockshin, Zahra Zakeri

Publications and Research

Background: Cells taken from mouse embryos before sex differentiation respond to insults according to their chromosomal sex, a difference traceable to differential methylation. We evaluated the mechanism for this difference in the controlled situation of their response to ethanol.

Methods: We evaluated the expression of mRNA for alcohol dehydrogenase (ADH), aldehyde dehyrogenases (ALDH), and a cytochrome P450 isoenzyme (Cyp2e1) in male and female mice, comparing the expressions to toxicity under several experimental conditions evaluating redox and other states.

Results: Females are more sensitive to ethanol. Disulfiram, which inhibits alcohol dehydrogenase (ADH), increases cell death in males, eliminating the sex …

Polygenic Risk Score Analysis Revealed Shared Genetic Background In Attention Deficit Hyperactivity Disorder And Narcolepsy, Nagahide Takahashi, Tomoko Nishimura, Taeko Harada, Akemi Okumura, Damee Choi, Toshiki Iwabuchi, Hitoshi Kuwabara, Shu Takagi, Yoko Nomura, Jeffrey H. Newcorn, Nori Takei, Kenji J. Tsuchiya

Publications and Research

Attention deficit hyperactive disorder (ADHD) is a highly heritable neurodevelopmental disorder, and excessive daytime sleepiness is frequently observed in ADHD patients. Excessive daytime sleepiness is also a core symptom of narcolepsy and essential hypersomnia (EHS), which are also heritable conditions. Psychostimulants are effective for the symptomatic control of ADHD (primary recommended intervention) and the two sleep disorders (frequent off-label use). However, the common biological mechanism for these disorders has not been well understood. Using a previously collected genome-wide association study of narcolepsy and EHS, we calculated polygenic risk scores (PRS) for each individual. We investigated a possible genetic association between …

Sas Data Curation Primer, Qiong Xu

Publications and Research

This primer was created as part of the "Specialized Data Curation" Workshop #3 held at Washington University in St. Louis, MO on November 5-6, 2019. Exploring SAS application and how researchers generated, stored, and shared their SAS data sets, this work summarized the key features of SAS data and explained how to curate SAS data in institutional data repositories. This primer can be used as a manual for research data curators or librarians to document SAS data for the purpose of data preservation and sharing.

Microspheres With Atomic-Scale Tolerances Generate Hyperdegeneracy, Jacob Kher-Alden, Shai Maayani, Leopoldo L. Martin, Mark Douvidzon, Lev Deych, Tal Carmon

Publications and Research

Degeneracies play a crucial rule in precise scientific measurements as well as in sensing applications. Spherical resonators have a high degree of degeneracy thanks to their highest symmetry; yet, fabricating perfect spheres is challenging because even a stem to hold the sphere breaks the symmetry. Here we fabricate a levitating spherical resonator that is evanescently coupled to a standard optical fiber. We characterize the resonators to exhibit an optical quality factor exceeding a billion, 10 μm radius, and sphericity to within less than 1µ. Using our high quality and sphericity, we experimentally lift degeneracies of orders higher than 200, which …

Learning Strategies And Metacognition In Adults With Dyslexia, Bradley W. Bergey

Publications and Research

In this chapter, we review the literature on learning and study strategies of university students with reading disabilities. Increasing numbers of students with reading disabilities attend post-secondary education, and while there, many experience academic challenges related to their remaining reading problems. We propose that learning and study strategies are important compensatory mechanisms for these students, but conclude not much is currently known about the learning and study strategies that students with reading disabilities employ in post-secondary education. As a way forward, we identify measurement and sampling issues in existing studies as potentially responsible for the varied results and discuss the …

Flavour Profile (Vanilla: A Global History), Rosa Abreu

Publications and Research

No abstract provided.

A Tale Of Winglets: Evolution Of Flight Morphology In Stick Insects, Yu Zeng, Connor O'Malley, Sonal Singhal, Faszly Rahim, Sehoon Park, Xin Chen, Robert Dudley

Publications and Research

The evolutionary transition between winglessness and a full-winged morphology requires selective advantage for intermediate forms. Conversely, repeated secondary wing reductions among the pterygotes indicates relaxation of such selection. However, evolutionary trajectories of such transitions are not well-characterized. The stick insects (Phasmatodea) exhibit diverse wing sizes at both interspecific and intersexual levels, and thus provide a system for examining how selection on flight capability, along with other selective forces, drives the evolution of flight-related morphology. Here, we examine variation in relevant morphology for stick insects using data from 1,100+ individuals representing 765 species. Although wing size varies along a continuous spectrum, …

Sperm Storage Reduces The Strength Of The Mate-Finding Allee Effect, María V. Jiménez-Franco, Andrés Giménez, Roberto C. Rodríguez-Caro, Ana Sanz-Aguilar, Francisco Botella, Jose D. Anadon, Thorsten Wiegand, Eva Graciá

Publications and Research

Mate searching is a key component of sexual reproduction that can have important implications for population viability, especially for the mate-finding Allee effect. Interannual sperm storage by females may be an adaptation that potentially attenuates mate limitation, but the demographic consequences of this functional trait have not been studied. Our goal is to assess the effect of female sperm storage durability on the strength of the mate-finding Allee effect and the viability of populations subject to low population density and habitat alteration. We used an individual-based simulation model that incorporates realistic representations of the demographic and spatial processes of our …

Association Of Genetic Risks With Autism Spectrum Disorder And Early Neurodevelopmental Delays Among Children Without Intellectual Disability, Nagahide Takahashi, Taeko Harada, Tomoko Nishimura, Akemi Okamura, Damee Choi, Toshiki Iwabuchi, Hitoshi Kuwabara, Shu Takagai, Yoko Nomura, Nori Takei, Kenji J. Tsuchiya

Publications and Research

IMPORTANCE Autism spectrum disorder (ASD) is highly heritable, and modest contributions of common genetic variants to ASD have been reported. However, the association of genetic risks derived from common risk variants with ASD traits in children from the general population is not clear, and the association of these genetic risks with neurodevelopment in infants has not been well understood.

OBJECTIVE To test whether a polygenic risk score (PRS) for ASD is associated with neurodevelopmental progress at age 18 months and ASD traits at age 6 years among children from the general population.

DESIGN, SETTING, AND PARTICIPANTS In this cohort study, …

Prevalence Of Left-Handedness In China 2011: Small-Area Estimates, Hongwei Xu

Publications and Research

Nationally representative survey data and small-area estimation techniques are used to assess the geographic prevalence of left-handedness in China 2011. Measures of individuals’ handedness are their self-reported dominant hand and their hand grip strength, which yield four estimates of left-handed prevalence, and these statistics are recorded at the provincial level. These estimates concord with one another. There are several geographic clusters of high-prevalence rates of left-handers located in ethnic minority-designated autonomous areas or historically revolutionary base areas, which may reflect a deep-rooted sense of defiance to authorities and promote such cultural values as individual autonomy and equality among local people.

Antibacterial, Antifungal, Antioxidant Activity And Polyphenol Content Of Aerial Parts And Bulbs Of Allium Schugnanicum., Saidbeg Satorov, F. Mirzoeva, Sh. Kurbonbekova, Sh. Satorov, M. Vakhidova, Vyacheslav Dushenkov

Publications and Research

Objective: То study of antibacterial, antifungal and antioxidant activity, and content of polyphenols in the bulb and aerial parts of an endemic species of onion A. schugnanicum. Methods: An ethanol-based extract was prepared from fresh plants. Total polyphenolic content (Folin) and ABTS antioxidant capacity assays were used to characterized extracts. Extracts obtained from bulbs, peduncle, and seeds demonstrated antibacterial activity against the reference Staphylococcus aureus (ATCC 4929), Pseudomonas aeruginosa (ATCC 4930) and Klebsiella pneumoniae (ATCC 4927) strains, as well as against the hospital strains of the same types of bacteria, i.e. strains isolated from inpatient surgical patients. Results: The study …