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Full-Text Articles in Entire DC Network
Investigating Genetic Regulators Of Crystal Cell Development In Drosophila Melanogaster, Andrea Feria, Nyla Walbrook, Anisa Turaeva, Rebecca Spokony
Investigating Genetic Regulators Of Crystal Cell Development In Drosophila Melanogaster, Andrea Feria, Nyla Walbrook, Anisa Turaeva, Rebecca Spokony
Publications and Research
Crystal cells, a subset of Drosophila melanogaster hemocytes, are important for melanization, a crucial immune response. While the genetic regulation of crystal cell develop remains incompletely understood, this study investigates the functions of five candidate genes: ACXB, ACXA, Gp210, CG4390, and Cyp4s3; identidied through previous genome-wide association studies. Using the Gal4/UAS system along with RNA interference (RNAi), we exclusively knocked down each gene in third instar larvae and quantified crystal cell populations following heat shock-induced melanization. Our results imply that the knockdown of ACXB and ACXA significantly increased crystal cell counts in both sexes, suggesting these genes either act as …
Phylogenetic Relationships And Species Delimitation Of Bunchgrass Lizards Of The Genus Sceloporus From Mexico With The Description Of A New Species, Tristan Charran, Jesús A. Loc-Barragan, Rafael Alejandro Calzada-Arciniega, Liz A. Alfaro-Juantorena, Raúl Cueva Del Castillo, Christopher Blair, Víctor H. Jiménez-Arcos
Phylogenetic Relationships And Species Delimitation Of Bunchgrass Lizards Of The Genus Sceloporus From Mexico With The Description Of A New Species, Tristan Charran, Jesús A. Loc-Barragan, Rafael Alejandro Calzada-Arciniega, Liz A. Alfaro-Juantorena, Raúl Cueva Del Castillo, Christopher Blair, Víctor H. Jiménez-Arcos
Publications and Research
Molecular data continue to serve as an invaluable tool to assess species limits and patterns of cryptic diversity, particularly in areas harboring high levels of biodiversity. The Sceloporus scalaris group, known as bunchgrass lizards, contains 13 described and one undescribed species distributed throughout high elevation biotas of Mexico. However, recent studies suggest that diversity in the group may be substantially underestimated. We collect new sequence data from four independent loci to determine the evolutionary distinctiveness and phylogenetic relationships of an isolated population of bunchgrass lizard in the Sierra San Juan (SSJ) in the Mexican state of Nayarit. Concatenation and coalescent-based …
Primates From Senèze, Eric Delson
Primates From Senèze, Eric Delson
Publications and Research
Senèze has yielded two primate fossils, neither from the recent field work. A partial ulna can be identified as cf. Macaca sylvanus. A nearly complete female skull is the holotype of Dolichopithecus arvernensis Depéret, 1928, now included in Paradolichopithecus. Emended and differential diagnoses are provided for this genus and species for the first time, and the Senèze skull is described and briefly compared to those of other species of the genus. Dental and cranial measurements are provided, along with comparative data. The macaque and Paradolichopithecus are moderately to highly terrestrial, respectively, and they suggest a woodland to more open …
Open Educational Resources For A More Just Romanticism, Leila Walker
Open Educational Resources For A More Just Romanticism, Leila Walker
Publications and Research
Efforts to diversify the field of Romanticism, long overdue, have intensified
recently, and many Romanticist organizations now sponsor programmes
aimed at amplifying Black and Brown voices. Most of these efforts have
focused on content: how to present Romanticism as a global movement
and include non-white authors in our anthologies and syllabi. While these
much-needed changes address some of the field’s traditional blind spots,
they do little to materially benefit our most vulnerable students or to
address the structural barriers that maintain Romanticism’s exclusionary
status quo. Open educational resources, or OERs, are one way to begin
productively transforming the way the …
Everyday Life Information Behavior, Health Information Seeking, And Hiv And Sti Awareness Among People Who Inject Drugs (Pwid), Nafiz Z. Shuva, Radia Taisir, Parvez Sazzad Mallick
Everyday Life Information Behavior, Health Information Seeking, And Hiv And Sti Awareness Among People Who Inject Drugs (Pwid), Nafiz Z. Shuva, Radia Taisir, Parvez Sazzad Mallick
Publications and Research
This study aims to explore the everyday life and health information behavior of people who inject drugs (PWID) in Bangladesh, as well as the effectiveness of HIV and STI informational programs in promoting safe injecting and sexual behavior. The study received 97 completed survey responses and conducted two focus group discussions (FGDs) with 13 PWID. Using de Certeau's everyday life practices framework, the study aims to understand the tactical information strategies of PWID in the context of a developing country where access to government services and trust in authorities may be significantly limited among marginalized populations. PWID's information needs focused …
Haptic Processing: How The Shutter Button Shapes Photography, Sean Scanlan
Haptic Processing: How The Shutter Button Shapes Photography, Sean Scanlan
Publications and Research
The goal of this essay is to explore the haptics of taking photographs in the digital age. More specifically, I examine the evolving relationship between the body and imaging technologies. The body must, somehow, interact with the camera shutter, whether the shutter is a simple mechanical door or an electrical timing network switch. Human intention has to activate the switch via a button, even if this intention is complicated: since 2012, mobile phones can take photos using voice commands, relieving the need to physically touch the shutter button. One does not necessarily need to use the fundamental levers often associated …
Locational Data And The Public Interest, William A. Herbert, Micahel Goodchild, Richard Appelbaum, Jeremy Crampton, Gary Langham, Krzysztof Janowicz, Mei-Po Kwan, Katina Michael, Lisa Schamess
Locational Data And The Public Interest, William A. Herbert, Micahel Goodchild, Richard Appelbaum, Jeremy Crampton, Gary Langham, Krzysztof Janowicz, Mei-Po Kwan, Katina Michael, Lisa Schamess
Publications and Research
This article presents a paper developed by the AAG Organizing Committee on Locational Information and the Public Interest through a summit held in Santa Barbara, California in June 2022. The summit resulted in goals and ideas for addressing the issues that arise from the present environment for geodata, whereby public, private, and third-sector entities can tap into publicly available locational information with relatively little regulation on its access or use. The Committee articulates four goals: (1) develop a research agenda extending across disciplines, (2) outline educational resources and strategies to guide ethical practice, (3) devise a pathway to increase public …
Becoming Adults: Immigrant And Second-Generation Dominican Youth In The U.S., Evelyn Fernández-Ketcham
Becoming Adults: Immigrant And Second-Generation Dominican Youth In The U.S., Evelyn Fernández-Ketcham
Publications and Research
This study offers new evidence on the question of developmental studies, particularly in relation to the stage that covers the transition to adulthood. The publication at hand provides strong added value by introducing new demographic groups, new scenarios, and new methods to examine the Dominican youth experience.
Bibliographic Instruction And The Need For “Librarian-First” Oer Repositories, Michael Kirby
Bibliographic Instruction And The Need For “Librarian-First” Oer Repositories, Michael Kirby
Publications and Research
No abstract provided.
Atorvastatin Alters Neuronal Morphology Data Set, Carolyn L. Pytte
Atorvastatin Alters Neuronal Morphology Data Set, Carolyn L. Pytte
Publications and Research
Statins are highly effective and widely prescribed cholesterol lowering drugs. However, statins cross the blood-brain barrier and decrease neural cholesterol in animal models, raising concern that long-term statin use may impact cholesterol-dependent structures and functions in the brain. Cholesterol is a fundamental component of cell membranes and experimentally decreasing membrane cholesterol has been shown to alter cell morphology in vitro. In addition, brain regions that undergo adult neurogenesis rely on local brain cholesterol for the manufacture of new neuronal membranes. Thus neurogenesis may be particularly vulnerable to long-term statin use. Here we asked whether oral statin treatment impacts neurogenesis …
Technology And Coding The Great Equalizer: A Case Study Of A Formerly Incarcerated Leader, Joni Schwartz
Technology And Coding The Great Equalizer: A Case Study Of A Formerly Incarcerated Leader, Joni Schwartz
Publications and Research
Providing meaningful educational and employment opportunities for returning incarcerated citizens from marginalized communities contributes to a more sustainable future for all. This chapter examines the barriers faced by returning incarcerated citizens in employment and presents a case study of a Dario Peña, who is a formerly incarcerated citizen. Peña's lived experience, leadership preparation, vision, and bottom-up leadership made him a leader for the Justice through Code program, which aims to provide prisoners and returning citizens with professional skills to create a sustainable career in the tech industry. Anchored in Critical Race Theory (CRT), this chapter delves into structural inequalities like …
Does Performance Change Budgets? Punctuated Equilibrium, Performance, And The Budget For Juvenile Justice In An American State, Elaine Yi Lu, Robert Hines, Katherine Willoughby
Does Performance Change Budgets? Punctuated Equilibrium, Performance, And The Budget For Juvenile Justice In An American State, Elaine Yi Lu, Robert Hines, Katherine Willoughby
Publications and Research
How performance informs budgeting and budgets is contentious and unclear. Applying punctuated equilibrium theory, this research seeks to understand if performance information once placed on the media and macropolitical agendas can lead to long term budgetary shifts. This research highlights how the accumulation of performance information punctuated the funding scheme and created a new equilibrium over time.
This research uses mixed methods to study the impact of performance on Florida’s (USA) Department of Juvenile Justice (DJJ) over a 20-year period. First, we conduct a media review of 400 randomly sampled newspaper articles to characterize the media discourse around the DJJ …
Identifying Intangible And Biocultural Heritage Elements Toward Environmental Understanding: Engaging Stakeholders Through Art, Martha B. Lerski
Identifying Intangible And Biocultural Heritage Elements Toward Environmental Understanding: Engaging Stakeholders Through Art, Martha B. Lerski
Publications and Research
Grounded in a case study in Barbuda in the Caribbean, this research examines sustainability from the perspective of what arts and heritage can contribute to community engagement and local and broader understandings about the environment. This article documents a growing body of literature recognizing the role of arts and culture, including local knowledge and traditional ecological knowledge (TEK), in climate change endeavors. Art and TEK present expansive world views. Contextual information situates research done on the island of Barbuda pre- and post-Hurricane Irma. Visual arts workshops engaged community members in mixed methods research. Results documented cultural elements, particularly intangible and …
Chatbot Assessment: Best Practices For Artificial Intelligence In The Library, Michelle Ehrenpreis, John P. Delooper
Chatbot Assessment: Best Practices For Artificial Intelligence In The Library, Michelle Ehrenpreis, John P. Delooper
Publications and Research
In November 2019, the Leonard Lief Library implemented Ivy.ai, a proprietary chatbot on its website. This implementation was the first academic library installation of a vendor-supplied chatbot to be discussed in the professional literature. This chatbot functioned as a new tool that assisted users seeking information from the library website. User questions provided insight to the authors about the kinds of topics students searched for via the library website. In April 2023, the chatbot’s vendor began using OpenAI’s ChatGPT Application Programming Interface (API) to improve the chatbot’s functionality. This change, from a rules-based chatbot system to a transformer model, enhanced …
Multiplicity, Belonging, And Free Speech In Us Higher Education: Thriving Through Current Crises, Naomi Zack
Multiplicity, Belonging, And Free Speech In Us Higher Education: Thriving Through Current Crises, Naomi Zack
Publications and Research
New realities in U.S. higher education present a multifaceted crisis for students, faculty, administrators, and society at large. This book provides incisive diagnoses of pressing problems and prescriptions to reinstate and support U.S. higher education as an intellectually and ethically valuable institution.
Repressed Memories And The Body Keeps The Score: Public Perceptions And Prevalence, Kris-Ann S. Anderson, Quincy C. Miller, Deryn Strange, Kamala London
Repressed Memories And The Body Keeps The Score: Public Perceptions And Prevalence, Kris-Ann S. Anderson, Quincy C. Miller, Deryn Strange, Kamala London
Publications and Research
The “memory wars” resurgence has renewed debates over the validity of repressed memories. This revival appears linked to factors such as changing statutes of limitations, confusion about repression, and unchallenged social media content. In a nationally representative online survey of American adults (N = 1581), we examined (a) beliefs in repression and the body keeps the score, (b) the prevalence of recovered memory claims, and (c) the impact of question phrasing on recovered memory reporting. An overwhelming 94% of respondents expressed belief in repressed memory, and 77% endorsed the idea that the body keeps the score. Additionally, 3.6% (n = …
Myrtillin As A Promising Immunomodulator: Molecular Modeling And Pharmacokinetic Evaluation, Adolat Manakbayeva, Timur Kerimov, I D. Ershov, E. I. Anarkulova, Pavel Alexyuk, Y Moldakhanov, Ahdrey P. Bogoyavlenskiy, Vyacheslav Dushenkov
Myrtillin As A Promising Immunomodulator: Molecular Modeling And Pharmacokinetic Evaluation, Adolat Manakbayeva, Timur Kerimov, I D. Ershov, E. I. Anarkulova, Pavel Alexyuk, Y Moldakhanov, Ahdrey P. Bogoyavlenskiy, Vyacheslav Dushenkov
Publications and Research
Myrtillin, an anthocyanin found in blueberry fruits, is known for its antioxidant and potentially immunomodulatory properties. In this study, molecular docking was used to evaluate its interactions with a wide panel of immune-related proteins, including pro-inflammatory cytokines (TNF-α, IL-6, IL-17), antiinflammatory mediators (IL-4, IL-10), and signaling pathway proteins (1NFK, p52/RelB). The in silico results were supported by interaction analysis, and an ADMET analysis was conducted to assess the pharmacokinetic and toxicological profile. The findings confirm the promise of Myrtillin as a natural modulator of inflammatory responses.
Total Polyphenol Content, Antioxidant Potential, Antibacterial And Antifungal Properties Of Ferula L. Species Growing In Tajikistan, Saidbeg Satorov, Sulkhya Mavlonazarova, Salomuddin Yusufi, Vyacheslav Dushenkov
Total Polyphenol Content, Antioxidant Potential, Antibacterial And Antifungal Properties Of Ferula L. Species Growing In Tajikistan, Saidbeg Satorov, Sulkhya Mavlonazarova, Salomuddin Yusufi, Vyacheslav Dushenkov
Publications and Research
The plants of the genus Ferula L. have long been recognized for their significant roles in traditional medicine in the Middle East and Asia, a heritage that we deeply respect and appreciate. A diverse array of biologically active compounds, particularly concentrated in the roots of various Ferula species, accounts for their broad range of medicinal properties and applications in folk medicine. Many species within this genus are noted for their high content of phenolic compounds, which exhibit potent antioxidant activity and demonstrate substantial antimicrobial and antifungal properties.
Bringing The Library Into Brightspace, Stephen Francoeur, Rebecca Hyams, John Delooper, Robin Naughton, Eric Silberberg
Bringing The Library Into Brightspace, Stephen Francoeur, Rebecca Hyams, John Delooper, Robin Naughton, Eric Silberberg
Publications and Research
This panel presentation highlights collaboration among CUNY libraries and LMS administrators to automate integration of library course reserves, research guides and other web-based services into Brightspace. The presentation begins discussing how learning tools interoperability (LTI) integration provides library resources to students at their point of need. It then describes the technical requirements to automate and customize the Springshare LTI library platform within Brightspace. The panel concludes with examples from several campuses demonstrating what this integration looks like.
Leveraging Ai Tools In University Writing Instruction: Enhancing Student Success While Upholding Academic Integrity, Daisuke Akiba, Rebecca Garte
Leveraging Ai Tools In University Writing Instruction: Enhancing Student Success While Upholding Academic Integrity, Daisuke Akiba, Rebecca Garte
Publications and Research
The emergence of AI-powered Large Language Models (LLMs), such as ChatGPT and Google Gemini, presents both opportunities and challenges for higher education, particularly regarding academic integrity in writing instruction. This exploratory study examines a novel pedagogical approach that integrates LLMs as required feedback tools in a university-level psychology writing assignment. The exclusive online approach emphasizes improvement through revision, requiring students to obtain AI-generated feedback on ungraded initial drafts based on an instructor-provided rubric, with final assessment focused on the quality of subsequent revisions. Analysis of survey data from 39 undergraduate students, incorporating both quantitative measures and qualitative responses, revealed several …
Cellular Signatures In Human Blood Track Bone Mineral Density In Postmenopausal Women, Kaichi Kaneko, Jefferson Tsai, Deniece Meñez, Brian Oh, Andrew Junwoo Suh, Seyeon Bae, Masataka Mizuno, Akio Umemoto, Eugenia G. Giannopoulou, Takayuki Fujii, Yaxia Zhang, Emily M. Stein, Richard S. Bockman, Kyung-Hyun Park-Min
Cellular Signatures In Human Blood Track Bone Mineral Density In Postmenopausal Women, Kaichi Kaneko, Jefferson Tsai, Deniece Meñez, Brian Oh, Andrew Junwoo Suh, Seyeon Bae, Masataka Mizuno, Akio Umemoto, Eugenia G. Giannopoulou, Takayuki Fujii, Yaxia Zhang, Emily M. Stein, Richard S. Bockman, Kyung-Hyun Park-Min
Publications and Research
Osteoclasts are the sole bone-resorbing cells and are formed by the fusion of osteoclast precursor cells (OCPs) derived from myeloid lineage cells. Animal studies reveal that circulating OCPs (cOCPs) in blood travel to bone and fuse with bone-resident osteoclasts. However, the characteristics of human cOCPs and their association with bone diseases remain elusive. We have identified and characterized human cOCPs and found a positive association between cOCPs and osteoclast activity. Sorted cOCPs have a higher osteoclastogenic potential than other myeloid cells and effectively differentiate into osteoclasts. cOCPs exhibit distinct morphology and transcriptomic signatures. The frequency of cOCPs in the blood …
Effects Of Surface Treatment On Adhesive Performance Of Composite-To-Composite And Composite-To-Metal Joints, Nikhil Paranjpe, Md. Nizam Uddin, Akm S. Rahman, Ramazan Asmatulu
Effects Of Surface Treatment On Adhesive Performance Of Composite-To-Composite And Composite-To-Metal Joints, Nikhil Paranjpe, Md. Nizam Uddin, Akm S. Rahman, Ramazan Asmatulu
Publications and Research
This study deals with the long-running challenge of joining similar and dissimilar materials using composite-to-composite and composite-to-metal joints. This research was conducted to evaluate the effects of surface morphology andsurfacetreatments onthemechanicalperformanceofadhesively bonded joints used for the aircraft industry. A two-segment, commercially available, toughened epoxy was chosen as the adhesive. Unidirectional carbon fiber prepreg and aluminum 2021-T3 alloys were chosen for the composite and metal panels, respectively. Surface treatment of the metal included corrosion elimination followed by a passive surface coating of Alodine®. A combination of surface treatment methods was used for the composite and metal specimens, including detergent cleaning, plasma …
The Importance Of Probes In Assessing Periodontal Health, Khrystyna Vyprynyuk, Catherine Monchik
The Importance Of Probes In Assessing Periodontal Health, Khrystyna Vyprynyuk, Catherine Monchik
Publications and Research
No abstract provided.
The Importance Of Humanities In A Career-Focused Educational Environment, Geoff Zylstra, Jill Belli, Candido Cabo, Sean Macdonald, Robin Michals, Ann Marie Sowder, Christopher B. Swift
The Importance Of Humanities In A Career-Focused Educational Environment, Geoff Zylstra, Jill Belli, Candido Cabo, Sean Macdonald, Robin Michals, Ann Marie Sowder, Christopher B. Swift
Publications and Research
The humanities have the potential to enhance STEM curriculum in career-oriented professional degree programs. As part of a larger college-wide initiative to develop interdisciplinary curricula, the National Endowment for the Humanities (NEH) awarded a grant to New York City College of Technology to explore the relationship between the humanities and career-focused degree programs in STEM departments. This article describes the design and implementation of coursework that bridges the curricular divides between humanities disciplines and technical or career-focused disciplines by bringing the humanities to bear on science and technology-oriented courses. Specifically, the humanities served to improve technical skills for students in …
Immunomodulation Of Macrophages In Diabetic Wound Individuals By Structurally Diverse Bioactive Phytochemicals, Krishnendu Adhikary, Riya Sarkar, Sriparna Maity, Ishani Sadhukhan, Riya Sarkar, Krishnendu Ganguly, Saurav Barman, Rajkumar Maiti, Sanjoy Chakraborty, Tandra R. Chakraborty, Debasis Bagchi, Pradipta Banerjee
Immunomodulation Of Macrophages In Diabetic Wound Individuals By Structurally Diverse Bioactive Phytochemicals, Krishnendu Adhikary, Riya Sarkar, Sriparna Maity, Ishani Sadhukhan, Riya Sarkar, Krishnendu Ganguly, Saurav Barman, Rajkumar Maiti, Sanjoy Chakraborty, Tandra R. Chakraborty, Debasis Bagchi, Pradipta Banerjee
Publications and Research
Diabetes-related ulcers and slow-healing wounds pose a significant health risk to individuals due to their uncertain causes. Mortality rates for diabetes foot ulcers (DFUs) range from 10% after 16 months to 24% after five years. The use of bioactive phytochemicals can play a key role in healing wounds in a predictable time. Recent literature has demonstrated that various natural substances, including flavonoids, saponins, phenolic compounds, and polysaccharides, play key roles at different stages of the wound-healing process through diverse mechanisms. These studies have categorized the compounds according to their characteristics, bioactivities, and modes of action. In this study, we evaluated …
"Finding Your People: Seeking Strength And Solidarity In Employee Resource Groups (Ergs)" - The One Club For Creativity's "Where Are All The Black People?" 2024 Conference Proceedings & Reading List, Javier O. Garcia
Publications and Research
Employee Resource Groups (ERGs) help create community in the workplace, and can serve as a source of strength for employees of marginalized identities.
This panel, originally held at The One Club for Creativity's "Where Are All the Black People?" conference and career fair in 2024, explores the value of intersectional identities in the workplace.
The featured panelists offer insights into the changing landscape of DE&I (diversity, equity, & inclusion) - particularly in the advertising, marketing communications, and creative industries - the impact it is having on employees, and how ERGs can serve as a catalyst for professional and organizational growth. …
Editorial For “Automated Breast Density Assessment In Mri Using Deep Learning And Radiomics: Strategies For Reducing Inter-Observer Variability”, Pegah Khosravi
Editorial For “Automated Breast Density Assessment In Mri Using Deep Learning And Radiomics: Strategies For Reducing Inter-Observer Variability”, Pegah Khosravi
Publications and Research
No abstract provided.
Burnout: Half A Century Of Controversy, Renzo Bianchi, Irvin Sam Schonfeld
Burnout: Half A Century Of Controversy, Renzo Bianchi, Irvin Sam Schonfeld
Publications and Research
Burnout has become a focal point of concern in the contemporary workplace. The syndrome has elicited undiminished interest among occupational health specialists. The World Health Organization defines burnout as a syndrome "resulting from chronic workplace stress." Burnout is said to comprise three components: (i) feelings of energy depletion or exhaustion; (ii) increased mental distance from one’s job, or feelings of negativism or cynicism toward one’s job; and (iii) a sense of ineffectiveness and lack of accomplishment. This definition mirrors the conceptualization of burnout embodied in the Maslach Burnout Inventory (MBI), the ‘gold standard’ for the assessment of burnout. However, controversies …
Recent Evolution In Thermochemical Transformation Of Municipal Solid Wastes To Alternate Fuels, Tumpa R. Sarker, Lucky Khatun, Bangladesh Agricultural University, Rostom Ali, Shariful Islam, Sagor Chowdhury, Kazi Sakibur Rahman, Nafis Sadique Sayem, Akm S. Rahman
Recent Evolution In Thermochemical Transformation Of Municipal Solid Wastes To Alternate Fuels, Tumpa R. Sarker, Lucky Khatun, Bangladesh Agricultural University, Rostom Ali, Shariful Islam, Sagor Chowdhury, Kazi Sakibur Rahman, Nafis Sadique Sayem, Akm S. Rahman
Publications and Research
The management of solid waste poses a worldwide obstacle in the pursuit of a sustainable society. This issue has intensified with the increase in waste production caused by rapid population expansion, industrialization, and urbanization. The continuously growing volume of municipal solid waste, particularly the substantial volume of organic waste, along with improper disposal practices, results in the release of greenhouse gases and other harmful airborne substances which simultaneously causes health risks and socioeconomic concerns. This article examines various waste-to-energy (energy production in the form of heat and electricity) concepts as well as waste-to-materials (various value-added materials including biofuel, biochemical, char, …
Srebp2 Restricts Osteoclast Differentiation And Activity By Regulating Irf7 And Limits Inflammatory Bone Erosion, Haemin Kim, In Ah Choi, Akio Umemoto, Seyeon Bae, Kaichi Kaneko, Masataka Mizuno, Eugenia Giannopoulou, Tania Pannellini, Liang Deng, Kyung-Hyun Park-Min
Srebp2 Restricts Osteoclast Differentiation And Activity By Regulating Irf7 And Limits Inflammatory Bone Erosion, Haemin Kim, In Ah Choi, Akio Umemoto, Seyeon Bae, Kaichi Kaneko, Masataka Mizuno, Eugenia Giannopoulou, Tania Pannellini, Liang Deng, Kyung-Hyun Park-Min
Publications and Research
Osteoclasts are multinucleated bone-resorbing cells, and their formation is tightly regulated to prevent excessive bone loss. However, the mechanisms by which osteoclast formation is restricted remain incompletely determined. Here, we found that sterol regulatory element binding protein 2 (SREBP2) functions as a negative regulator of osteoclast formation and inflammatory bone loss. Cholesterols and SREBP2, a key transcription factor for cholesterol biosynthesis, increased in the late phase of osteoclastogenesis. The ablation of SREBP2 in myeloid cells resulted in increased in vivo and in vitro osteoclastogenesis, leading to low bone mass. Moreover, deletion of SREBP2 accelerated inflammatory bone destruction in murine inflammatory …